Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| mutational analysis of sigma70 region 4 needed for appropriation by the bacteriophage t4 transcription factors asia and mota. | transcriptional activation of bacteriophage t4 middle promoters requires sigma70-containing escherichia coli rna polymerase, the t4 activator mota, and the t4 co-activator asia. t4 middle promoters contain the sigma70 -10 dna element. however, these promoters lack the sigma70 -35 element, having instead a mota box centered at -30, which is bound by mota. previous work has indicated that asia and mota interact with region 4 of sigma70, the c-terminal portion that normally contacts -35 dna and the ... | 2006 | 16996538 |
| epidural spinal cavernous hemangioma. | a 28-year-old woman presented with a rare primary epidural hemangioma without adjacent vertebral involvement manifesting as progressive paraparesis. magnetic resonance imaging of the thoracic spine showed an epidural lesion at t4-5 space appearing as isointense on t1-weighted images with enhancement by contrast medium and hyperintense on t2-weighted images. the lesion was totally removed microsurgically. histological examination revealed cavernous hemangioma. she made a complete recovery from he ... | 2006 | 16998281 |
| long term excessive zn-supplementation promotes metabolic syndrome-x in wistar rats fed sucrose and fat rich semisynthetic diet. | during the last two decades zinc (zn) as a micronutrient is being used indiscriminately in agricultural and husbandry practices and also in baby foods and multivitamin supplements with a view that zn is non-toxic and promotes linear growth and body weight in the consumers. the long-term effect of increasing zn load in the body has not been worked out so far. in this study, three groups of rats were fed on a semi-synthetic diet containing 20 mg (control, group-i), 40 mg (group-ii) and 80 mg zn /k ... | 2006 | 16999025 |
| [multimodal treatment in locally advanced esophageal cancer: a multicenter phase ii study with neoadjuvant oxaliplatin, 5-fluorouracil, leucovorin and neoadjuvant radiotherapy: preliminary results]. | the aim of the study was to evaluate the feasibility and efficacy of treatment with oxaliplatin, 5-fluorouracil and leucovorin concomitant with radiation therapy in locally advanced oesophageal cancer. fifty-eight patients with previously untreated, histologically proven oesophageal cancer were enrolled. downstaged patients underwent either surgery or received brachytherapy. we report the results obtained in the first 54 patients. the median age was 58 years. the diagnosis was squamous cell carc ... | 2006 | 16999147 |
| long-term follow-up of orthodontically treated deep bite patients. | the aim of this study was to evaluate the long-term stability of corrected deep bite and mandibular anterior crowding in a sample of 62 subjects (30 patients and 32 controls). the patients began treatment at a mean age of 12.2 years (sd 1.56). the treatment consisted of non-extraction and fixed appliances in 23 subjects and functional appliances in seven. the treatment group was compared with the control group with normal molar occlusion, normal overjet and overbite, no crowding, and without an ... | 2006 | 17000717 |
| effect of levothyroxine on total lipid profiles as assessed by analytical capillary isotachophoresis in a patient with hypothyroidism. | the patient was a 51-year-old japanese female who had been diagnosed with hyperlipidemia. at the first medical examination, her serum levels of total cholesterol (tc) and triglyceride (tg) were 482 and 205 mg/dl, respectively. since hyperlipidemia was not improved by pravastatin, atorvastatin or niceritrol, and since the levels of thyroid-stimulating hormone (tsh) and free t4 were 730 iu/ml and 0.3 ng/dl, respectively, the patient was diagnosed as secondary hyperlipidemia with hypothyroidism. a ... | 2006 | 17001111 |
| herbst treatment of class ii division 1 malocclusions in retrognathic and prognathic facial types. | the aim of this retrospective pilot study was to analyze and compare the short-term and long-term changes of herbst treatment in class ii division 1 subjects of the retrognathic and prognathic facial type. | 2006 | 17090166 |
| do the lungs contribute to propofol elimination in patients during orthotopic liver transplantation without veno-venous bypass? | the clearance of propofol is very rapid, and its transformation takes place mainly in the liver. some reports indicated extrahepatic clearance of the drug and that the lungs are the likely place where the process occurs. this study was undertaken to compare the plasma concentrations of propofol both in the pulmonary and radial arteries after constant infusion during the dissection, anhepatic and reperfusion phases of orthotopic liver transplantation (olt) without veno-venous bypass, attempting t ... | 2006 | 17085334 |
| cold-provocation testing for the vascular component of hand-arm vibration syndrome in health surveillance. | the aim was to investigate whether the use of infra-red thermography (i-r) and measurement of temperature gradients along the finger could improve the diagnostic accuracy of cold-provocation testing (15 degrees c for 5 min) in vascular hand-arm vibration syndrome (havs). twenty-one controls and 33 individuals with stages 2/3v havs were studied. the standard measurement of time to rewarm by 4 degrees c (t4 degrees c) and temperature gradients between the finger tip, base and middle (measured usin ... | 2006 | 17085918 |
| [effects of mixed cypermethrin and methylparathion on endocrine hormone levels and immune functions in rats: ii. interaction]. | to study interaction of mixed pesticides cypermethrin and methyl parathion on reproductive hormones, thyroid hormones, and immune functions in rats. | 2006 | 17086694 |
| intracranial arterial occlusive lesion in patients with graves' disease. | to investigate the distribution and clinical manifestations of intracranial arterial occlusive lesions (iaols), and their correlation with thyroid function. | 2006 | 17086733 |
| radical surgery for gallbladder carcinoma: possibilities of survival. | an aggressive surgical approach in the management of gallbladder cancer (gbc) has improved survival significantly in recent years. the aim of this retrospective study is to evaluate the long-term results of surgical treatment of gbc reassessed following the tnm staging system of the ajcc-2002. | 2006 | 17086863 |
| chemoradiotherapy with and without esophagectomy for advanced esophageal cancer. | to evaluate the impact of surgery on survival after chemoradiotherapy, we analyzed the long-term outcome of patients with advanced esophageal cancer. | 2006 | 17086873 |
| peptide yy (pyy)3-36 modulates thyrotropin secretion in rats. | peptide yy (pyy)3-36 is a gut-derived hormone, with a proposed role in central mediation of postprandial satiety signals, as well as in long-term energy balance. in addition, recently, the ability of the hormone to regulate gonadotropin secretion, acting at pituitary and at hypothalamus has been reported. here, we examined pyy3-36 effects on thyrotropin (tsh) secretion, both in vitro and in vivo. pyy3-36-incubated rat pituitary glands showed a dose-dependent decrease in tsh release, with 44 and ... | 2006 | 17088415 |
| acanthamoeba isolates belonging to t1, t2, t3, t4 and t7 genotypes from environmental freshwater samples in the nile delta region, egypt. | the free-living amoebae of the genus acanthamoeba include non-pathogenic and pathogenic species and has been recently classified into 15 different genotypes, t1-t15. in this study, a survey was conducted in order to determine the presence and pathogenic potential of free-living amoebae of acanthamoeba genus in freshwater sources associated with human activities in the nile delta region, egypt. identification of acanthamoeba was based on the morphology of cyst and trophozoite forms and pcr amplif ... | 2006 | 17078918 |
| transient hypothyroxinaemia in preterm infants. | thyroid hormones are required for normal development of the brain. transient hypothyroxinaemia is the most common thyroid dysfunction in preterm infants and is defined by temporary low levels of t4, t3 and normal or low tsh. low t4 levels in preterm infants are associated with persistent neurodevelopmental deficits in cognitive and motor function. thyroid hormone substitution trials to date are underpowered and show inconsistent results; the question remains -- are low t4 levels simply an epiphe ... | 2006 | 17079099 |
| cryoelectron microscopy and epr analysis of engineered symmetric and polydisperse hsp16.5 assemblies reveals determinants of polydispersity and substrate binding. | we have identified sequence and structural determinants of oligomer size, symmetry, and polydispersity in the small heat shock protein super family. using an insertion mutagenesis strategy that mimics evolutionary sequence divergence, we induced the ordered oligomer of methanococcus jannaschii hsp16.5 to transition to either expanded symmetric or polydisperse assemblies. a hybrid approach combining spin labeling epr and cryoelectron microscopy imaging at 10a resolution reveals that the underlyin ... | 2006 | 17079234 |
| sympathectomy for hyperhidrosis: should we place the clamps at t2-t3 or t3-t4? | endoscopic thoracic sympathectomy is routinely used to treat severe hyperhidrosis. it is usually performed at the t2-t3 level of the nerve, but may produce less severe compensatory hidrosis if performed at a lower level. this study evaluates the outcome of 1,274 patients who underwent endoscopic thoracic sympathectomy for plamar, plantar, axillary or facial hyperhidrosis/blushing. half of the patients were clamped at the t2-t3 level and half were clamped at the t3-t4 level. postsurgical symptoms ... | 2006 | 17083007 |
| a cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: pathology analysis of thyroid cancer cases in ukraine detected during the first screening (1998-2000). | the ukrainian american cohort study evaluated the risk of thyroid disorders in a group of individuals who were younger than age 18 years at the time of the chornobyl (chernobyl) accident. in this article, the authors describe the pathology of thyroid carcinomas detected in the first screening. | 2006 | 17083123 |
| hydranencephaly with cholestasis and giant hepatitis. | we present a rare case of hydranencephaly with cholestasis and giant hepatitis. studies for infectious agents were all negative including for the detection of virus in liver tissue by using polymerase chain reaction. although the anterior pituitary functions (cortisol, thyroid stimulating hormone, free t4, human growth hormone) were normal, the patient revealed massive cholestasis and giant hepatitis. | 2006 | 17063118 |
| [neoadjuvant treatment of rectal cancer: towards an individualised therapy]. | neoadjuvant radiation or chemoradiation followed by oncological resection is the current treatment of choice for locally advanced rectal cancer. profound diagnostics are mandatory to stratify patients for neoadjuvant treatment or primary surgery. here, magnetic resonance tomography most probably will become the standard modality due to its ability to predict involvement of the circumferential resection margin during surgery. while the initiation of chemoradiation in t4 rectal cancer and patients ... | 2006 | 17063435 |
| structure-guided mutational analysis of t4 rna ligase 1. | t4 rna ligase 1 (rnl1) is a trna repair enzyme that circumvents an rna-damaging host antiviral response. whereas the three-step reaction scheme of rnl1 is well established, the structural basis for catalysis has only recently been appreciated as mutational and crystallographic approaches have converged. here we performed a structure-guided alanine scan of nine conserved residues, including side chains that either contact the atp substrate via adenine (leu179, val230), the 2'-oh (glu159), or the ... | 2006 | 17068206 |
| dose-dependant hypothyroidism in mice induced by commercial trimethoprim-sulfamethoxazole rodent feed. | trimethoprim-sulfamethoxazole (tmp-smx) medication in the feed or water is commonly administered to immunocompro mised mice to prevent the occurrence of pneumocystis murina (formerly p. carinii) pneumonia. therapeutic doses of smx can cause decreased total and free thyroxine (t4) levels in dogs and thyroid hypertrophy and hyperplasia in mice, rats, and dogs. our primary objective was to determine whether smx at doses present in commercially available rodent tmp-smx feed would pro duce hypothyroi ... | 2006 | 17069024 |
| total intravenous anesthesia with propofol and remifentanil is associated with a nearly twofold higher incidence in postanesthetic shivering than desflurane-fentanyl anesthesia. | postanesthetic shivering (pas) is a frequent side effect of general anesthesia. previous reports on the incidence of pas of propofol for the induction or maintenance of anesthesia have been controversial, but have not been studied in detail. the aim of the present study was to evaluate the incidence and severity of pas in total intravenous anesthesia (tiva) with propofol and remifentanil compared with an inhalative anesthesia. | 2006 | 17072268 |
| dual olfactory pathway in the honeybee, apis mellifera. | the antennal lobes (als) are the primary olfactory centers in the insect brain. in the al of the honeybee, olfactory glomeruli receive input via four antennal sensory tracts (t1-4). axons of projection neurons (pns) leave the al via several antenno-cerebral tracts (acts). to assign the input-output connectivity of all glomeruli, we investigated the spatial relationship of the antennal tracts and two prominent al output tracts (medial and lateral act) mainly formed by uniglomerular (u) pns using ... | 2006 | 17072827 |
| rational attempts to optimize non-natural nucleotides for selective incorporation opposite an abasic site. | translesion dna synthesis represents the ability of a dna polymerase to misinsert a nucleotide opposite a dna lesion. previous kinetic studies of the bacteriophage t4 dna polymerase using a series of non-natural nucleotides suggest that pi-electron density of the incoming nucleotide substantially contributes to the efficiency of incorporation opposite an abasic site, a nontemplating dna lesion. however, it is surprising that these nonhydrogen-bonding analogues can also be incorporated opposite n ... | 2006 | 17073450 |
| health-related quality-of-life study in patients with carcinoma of the thyroid after thyroxine withdrawal for whole body scanning. | the authors studied the change of health-related quality of life (hr-qol) in patients with differentiated thyroid carcinoma (dtc) with thyroxine (t4) withdrawal in preparation for whole body radioactive iodine scanning. | 2006 | 17075410 |
| value of computed tomography-based tumor volume as a predictor of outcomes in hypopharyngeal cancer after treatment with definitive radiotherapy. | to investigate the value of pretreatment computed tomography (ct) volumetric analysis for the prediction of treatment outcome in patients with hypopharyngeal cancer (hpc) treated by definitive radiotherapy (rt). | 2006 | 17075415 |
| [central congenital hypothyroidism due to graves' disease in the mother]. | two male twins were born at a gestational age of 30 weeks. five days after delivery, the mother was diagnosed with graves' disease. the thyroid function in the neonates was therefore evaluated, which led to the detection of central congenital hypothyroidism (central cht), even though the neonatal cht-screening had been reported to be normal. both boys were treated with thyroxine up to the age of nine months. it was then established that their development had been uneventful. maternal graves' dis ... | 2006 | 17076354 |
| the effect of oral consumption of perchlorate, alone and in combination with ethanol, on plasma thyroid hormone and brain catecholamine concentrations in the rat. | literature has reported a controversy concerning the effects of the environmental pollutant perchlorate on pertinent physiological systems. however, no research to date has evaluated the effect of concomitant consumption of perchlorate and an additional environmental contaminant on physiological systems. the present preliminary investigation served to assess the effects of oral consumption of perchlorate, alone and in combination with ethanol, on thyroid hormone and brain catecholamine concentra ... | 2006 | 17076684 |
| occurrence of overt celiac disease in the elderly following total thyroidectomy. | we report the case of a female patient in whom gluten-induced entheropathy was revealed at the age of 71 yr by resistance to treatment with levothyroxine (l-t4), calcium carbonate and alfacalcidol. hypothyroidism and hypoparathyroidism were the consequence of a total thyroidectomy performed at the age of 65 yr for a large multinodular goiter. six months after thyroid ablation the patient started to complain of abdominal pain, diarrhea and weight loss. following, anemia and osteopenia were docume ... | 2006 | 17114916 |
| myxedema coma in a patient with down's syndrome. | hyroid dysfunction is common in down's syndrome, most common being hypothyroidism. longstanding, untreated hypothyroidism can lead to myxedema coma. | 2006 | 17112110 |
| imaging corticospinal tract connectivity in injured rat spinal cord using manganese-enhanced mri. | manganese-enhanced mri (mei) offers a novel neuroimaging modality to trace corticospinal tract (cst) in live animals. this paper expands this capability further and tests the utility of mei to image axonal fiber connectivity in cst of injured spinal cord (sc). | 2006 | 17112375 |
| effects of repetitive transcranial magnetic stimulation (rtms) on chronic tinnitus. | preliminary results indicate that repetitive transcranial magnetic stimulation (rtms) can suppress tinnitus for some people. however, several procedural questions need to be addressed before the results of tms studies can be interpreted or applied. for example, the placebo effect might be a significant factor because it is easy for patients to distinguish between real and sham stimulation. | 2006 | 17114152 |
| validity and reliability of active shape models for the estimation of cobb angles in adolescent idiopathic scoliosis. | choosing the most suitable treatment for scoliosis relies heavily on accurate and reproducible cobb angle measurement from successive radiographs. the objective is to reduce variability of cobb angle measurement by reducing user intervention and bias. custom software to automate cobb angle measurement from posteroanterior radiographs was developed using active shape models. validity and reliability of the automated system against a manual and semi-automated measurement method was conducted by tw ... | 2006 | 17108428 |
| prevalence and distribution of spinal osteoarthritis in women. | retrospective review of lateral spinal thoracolumbar radiographs, obtained to rule out spinal injury after trauma, were scored for osteoarthritis. | 2006 | 17108839 |
| colorectal cancer screening by non-invasive metabolic biomarker fecal tumor m2-pk. | to evaluate the utility of the innovative fecal tumor m2-pyruvate kinase (m2-pk) test in our daily clinical routine, as a marker for the pre-selection of patients who should subsequently undergo colonoscopy for the diagnosis or exclusion of colorectal cancer. | 2006 | 17109496 |
| levothyroxine replacement therapy after thyroid surgery. | new entities, such as 'subclinical' over- and undersubstitution, are easily diagnosed after thyroid surgery due to improved testing methods, and the incidence of thyroidectomy with lifelong hormone substitution is increasing. thus, there is a need to review conventional replacement therapy after thyroid surgery. we investigated the adequacy of our thyroid hormone replacement therapy for three months after total-, subtotal-, and hemithyroidectomy using an upper reference limit of thyrotropin (tsh ... | 2006 | 17067083 |
| [epidermoid carcinomas of anal canal treated with radiation therapy and concomitant chemotherapy (5-fluorouracil and cisplatin)]. | to evaluate our results after radiation therapy and concomitant chemotherapy in terms of local control, survival and toxicity in patients with anal cancer. | 2006 | 17110148 |
| thyroid hormone status of atlantic croaker exposed to aroclor 1254 and selected pcb congeners. | atlantic croaker (micropogonias undulatus) were exposed to the polychlorinated biphenyl (pcb) mixture (aroclor 1254) or one of three individual congeners (planar pcb 77 or ortho-substituted pcb 47 and pcb 153) in the diet for 30 days to investigate the effects of pcbs on circulating thyroid hormones, thyroxine (t4) and triiodothyronine (t3). aroclor 1254 (0.2 and 1.0 mg/kg body mass/day) decreased plasma t3 levels consistently, but the effects on t4 levels were inconsistent from year to year. ex ... | 2006 | 17110171 |
| the association of immunoreactive p53 and ki-67 with t-stage, grade, occurrence of metastases and survival in renal cell carcinoma. | the aim of this study was to clarify the association of p53 and ki-67 protein expressions with tumor characteristics and survival in renal cell carcinoma (rcc). | 2006 | 17094408 |
| pain and sensory dysfunction after breast cancer surgery: neurometer cpt evaluation. | the purpose of our study was to evaluate the presence of anatomical and functional damage to the afferent and sensorial fibres using the neurometer cpt test. a questionnaire regarding pain was sent to 300 women who had undergone surgery six months earlier. out of 300 patients 67 did not respond; 105 experienced no pain; while 128 felt pain. one hundred and twenty-eight women were divided into two groups: mastectomy with reconstruction and simple mastectomy. the intensity of pain at t0 in women w ... | 2006 | 17094410 |
| prognostic value of pre-operative serum ca 15.3 levels in breast cancer. | ca15.3 (also known as muci) is the most widely used marker in breast cancer. the aim of the present work was the evaluation of the prognostic value of preoperative serum ca15.3 levels in patients with primary breast cancer. | 2006 | 17094428 |
| [expression and clinical significance of hypoxia-inducible factor-1alpha in gastric cancer]. | hypoxia-inducible factor-1alpha (hif-1alpha) is correlated to the genesis, progression, invasion, metastasis, and prognosis of some malignancies. this study was to evaluate the expression of hif-1alpha in gastric cancer, and explore its correlation to clinical features of gastric cancer. | 2006 | 17094917 |
| effect site concentrations of remifentanil maintaining cardiovascular homeostasis in response to surgical stimuli during bispectral index guided propofol anestesia in seriously obese patients. | the aim of this prospective study was to determine the effect site concentrations of remifentanil maintaining cardiovascular homeostasis in response to surgical stimuli during bispectral index (bis) guided propofol anesthesia in seriously obese patients. | 2006 | 17095989 |
| potential role of novel hepatocellular carcinoma-associated gene idd01 in promoting tumorigenesis of hepg2 cell line. | we have used suppression subtractive hybridization to construct a subtracted cdna library of hepatocellular carcinoma (hcc) and isolated a panel of differential expression sequence tag (ests). by using bioinformatics and rapid amplification of cdna ends (race), we found a novel hcc-associated gene idd01. to further investigate its function, a recombinant eukaryotic vector pegfp/orf was constructed and transfected into the hepg2 cell line. | 2006 | 17097018 |
| [assessment of the quality of life in patients with differentiated thyroid carcinoma during a one-month withdrawal of levorotatory thyroxine preparations (l-t4) before a control diagnostics.] | introduction: monitoring of patients with differentiated thyroid carcinoma consists of a periodic control for thyroglobulin (tg) concentration and radioiodine diagnostics during stimulation of endogenous tsh. application of recombinant tsh is an alternative procedure which considerably increases cost of diagnostics but allows to avoid symptoms of hypothyreosis. this work was aimed at evaluating the influence of a withdrawal of l-t4 preparations preceding the control diagnostics on the quality of ... | 2006 | 17091459 |
| fluorescent analysis of translesion dna synthesis by using a novel, non-natural nucleotide analogue. | the replication of damaged dna is a promutagenic process that can lead to disease development. this report evaluates the dynamics of nucleotide incorporation opposite an abasic site, a commonly formed dna lesion, by using two fluorescent nucleotide analogues, 2-aminopurine deoxyribose triphosphate (2-aptp) and 5-phenylindole deoxyribose triphosphate (5-phitp). in both cases, the kinetics of incorporation were compared by using a 32p-radiolabel extension assay versus a fluorescence-quenching assa ... | 2006 | 17091513 |
| can principal components yield a dimension reduced description of protein dynamics on long time scales? | the suitability of principal component analysis (pca) to yield slow collective coordinates for use within a dimension reduced description of conformational motions in proteins is evaluated. two proteins are considered, t4 lysozyme and crambin. we present a quantitative evaluation of the convergence of conformational coordinates obtained with principal component analysis. detailed analyses of (>200 ns) molecular dynamics trajectories and crystallographic data suggests that simulations of a few na ... | 2006 | 17092036 |
| [therapy of cutaneous metastases of malignant melanoma]. | malignant melanoma represents a particular challenge for dermatologists and oncologists because of its high and increasing incidence and the poor prognosis of patients with thick primary tumors (t3, t4). in advanced stages of melanoma, cutaneous and subcutaneous metastases have a special significance, as they markedly affect the patient and may lead to a limitation in quality of life. while topical therapy is possible, there are only limited clinical studies. the location, number, size and distr ... | 2006 | 17103199 |
| characterization of several amino acid transports and glutamine metabolism in molt4 human t4 leukemia cells. | the transport system responsible for glutamine, alanine and glutamate in molt4 human t4 leukemia cell line were characterized. kinetic studies of sodium-dependent glutamine and alanine transport exhibited a single saturable high-affinity carrier with a michaelis constant of 152 +/- 26 microm and 203 +/- 36 microm and a maximal transport velocity of 960 +/- 165 and 1096 +/- 208 nmol/10(9)cells/min, respectively. glutamate uptake was less than one-tenth of glutamine and alanine, and linearly incre ... | 2006 | 17105494 |
| production of circular form of streptavidin rna aptamer in vitro. | rna aptamer is one of functional rnas selected experimentally from randomized rna pools, and has a high affinity and specificity against the target such as a protein and a small ligand. for therapeutic use of rna aptamer in vivo, both no side effects and escaping from rnase-induced degradation may be required. here we show a first evidence of producing a circular streptavidin aptamer in vitro generated by self-splicing permutated intron-exon (pie) sequences derived from gene td of t4 bacteriopha ... | 2006 | 17150948 |
| primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 japanese cases. | primary signet-ring cell colorectal carcinoma is rare and has been reported to have an extremely poor prognosis. the purpose of the present study was to define the characteristics of this cancer. | 2006 | 17153438 |
| intraoperative frozen section margin evaluation in gastric cancer of the cardia surgery. | the use of intraoperative frozen section to determine the extent of margin resection is a common practice. our aim was to identify the value of intraoperative frozen section in margin evaluation and to investigate its indication for gastric cancer of the cardia. | 2006 | 17153467 |
| a double-blind randomized placebo-controlled trial with short-term beta-glucuronidase therapy in children with chronic rhinoconjunctivitis and/or asthma due to dust mite allergy. | enzyme potentiated desensitization, in which beta-glucuronidase (bg) is administered with low doses of mixed allergens, was proposed in the 1970s for specific immunotherapy. the bg currently commercially available in a purified and standardized preparation devoid of any allergen has been suggested as a regulator in the allergic immune response, acting on the cytokine-network of type 2 helper t cells. a double-blind trial with a single-dose of bg proved effective in preventing symptoms in adult p ... | 2006 | 17153881 |
| dioxins and related compounds in albatrosses from the torishima island, japan: accumulation features by growth stage and toxicological implications. | concentrations of dioxins and related compounds (drcs), such as polychlorinated dibenzo-p-dioxins (pcdds), polychlorinated dibenzofurans (pcdfs), and coplanar polychlorinated biphenyls (co-pcbs), were determined in eggs, nestlings, and adults of black-footed albatross (bfa; diomedea nigripes) and short-tailed albatross (sta; diomedea albatrus) collected from the torishima island in japan during 2002, which is one of their breeding grounds. observed drc concentrations, especially pcdfs and non-or ... | 2006 | 17153995 |
| [graves' disease in the elderly]. | characterization of elderly (> or = 65) patients with graves' disease (gd) was discussed. emaciation was the symptom that was most frequently found in elderly patients. the presence of goiter, exophthalmos and increased appetite decreased with age, while weight loss, anorexia and arrhythmia increased. elderly patients often have serious complications such as congestive heart failure and atrial fibrillation. serum levels of free t3, free t4 and tsh receptor antibodies were significantly lower in ... | 2006 | 17154098 |
| melting curve of 4he: no sign of a supersolid transition down to 10 mk. | we have measured the melting curve of 4he in the temperature range from 10 to 400 mk with the accuracy of about 0.5 micro bar. crystals of different quality show the expected t4 dependence in the range from 80 to 400 mk without any sign of the supersolid transition, and the coefficient is in excellent agreement with available data on the sound velocity in liquid 4he and on the debye temperature of solid 4he. below 80 mk, we have observed a small deviation from t4 dependence, which, however, cann ... | 2006 | 17155407 |
| [a comparison of t3 sympathectomy versus t4 sympathectomy in the treatment of primary palmer hyperhidrosis]. | to evaluate the effect and side effect of t(3) versus t(4) sympathectomy in the surgical management of primary palmar hyperhidrosis through prospective multi-center randomized controlled trial. | 2006 | 17156625 |
| local and regional control in patients with papillary thyroid carcinoma: specific indications of external radiotherapy and radioactive iodine according to t and n categories in ajcc 6th edition. | to identify indications for external radiotherapy (ext) and radioactive iodine (rai) in papillary thyroid carcinoma (ptc), we conducted a retrospective study of local and regional control in 1297 patients diagnosed with ptc in a tertiary referral center. managed by surgery alone, patients with bilateral thyroidectomy had a lower rate of local relapse compared with lobectomy (p=0.02). ext improved locoregional (lr) failure-free survival (ffs) (p<0.001) and survival (p=0.01) in patients with gross ... | 2006 | 17158761 |
| cushing's disease arising from a clinically nonfunctioning pituitary adenoma. | a 49-yr-old woman with a large pituitary tumor leading to visual loss and galactorrhea- amenorrhea was submitted to transcranial pituitary surgery, when a clinically nonfunctioning pituitary adenoma was partially removed. histopathology and immunohistochemistry confirmed the diagnosis of "non-secreting atypical adenoma." at that time, serum and urinary free cortisol were normal, with low t4 levels and hyperprolactinemia. the patient was discharged on thyroxine and bromocriptine and treated with ... | 2006 | 17159252 |
| counseling patients receiving levothyroxine (l-t4) and calcium carbonate. | 2006 | 17162777 | |
| tumor volume as outcome determinant in patients treated with chemoradiation for locally advanced esophageal cancer. | the currently used tumor-node metastasis (tnm) staging method is generally not applicable to patients with unresectable esophageal carcinomas. there is a need for both an efficient, easy-to-perform clinical classification and for identification of pretherapeutic prognostic factors that would be useful for oncologists, one of which is tumor volume. | 2006 | 17148995 |
| fdg-pet in the initial staging of squamous cell oesophageal carcinoma. | squamous cell oesophageal carcinoma is the most common carcinoma of the oesophagus worldwide. the tumour stage as most important prognostic factor determines the clinical management. | 2006 | 17149491 |
| hexamerization of the bacteriophage t4 capsid protein gp23 and its w13v mutant studied by time-resolved tryptophan fluorescence. | the bacteriophage t4 capsid protein gp23 was studied using time-resolved and steady-state fluorescence of the intrinsic protein fluorophore tryptophan. in-vitro gp23 consists mostly of monomers at low temperature but forms hexamers at room temperature. to extend our knowledge of the structure and hexamerization characteristics of gp23, the temperature-dependent fluorescence properties of a tryptophan mutant (w13v) were compared to those of wild-type gp23. the w13v mutation is located in the n-te ... | 2006 | 17149929 |
| pro-angiogenesis action of thyroid hormone and analogs in a three-dimensional in vitro microvascular endothelial sprouting model. | our laboratory has recently demonstrated the pro-angiogenesis effects of thyroid hormone in the chick chorioallantoic membrane model. | 2006 | 17164749 |
| [observation on therapeutic effect of picking therapy on graves' disease]. | to observe therapeutic effect of picking therapy on graves' disease (gd) and its effects on thyroid function. | 2006 | 17165495 |
| [histologic response after neoadjuvant therapy in rectal adenocarcinoma: own experience and review of the literature]. | neoadjuvant therapy has improved outcomes for patients with locally advanced rectal cancer. aim authors: we studied the degree of histopathological regression after radiotherapy regimens commonly used in their clinical practice, and its effect on the pathology of by clinically founded t3-t4 rectal cancer. | 2006 | 17165600 |
| [regulatory expression of human interferon-gamma gene in murine bone marrow stromal cells by tet-off system]. | the tet-off system is a gene expression regulating system, which has high efficiency, low toxicity and strict turning-off function. this study was to investigate the regulatory expression of human interferon-gamma (ifngamma) gene in murine bone marrow stromal cells (bmscs) by tet-off system. | 2006 | 17166390 |
| [breast cancer with noninflammatory skin involvement: new data revise the traditional image of a "classical" clinicopathologic entity]. | historically, the presence of skin involvement results in the classification of a breast carcinoma into the highest tumor category, or accordingly into the highest non-metastatic disease stage (current tnm classification: t4/stage iii). however, probably the most important criterion of the tnm classification system is the basic rule that tumors exhibiting similar extension and prognosis should be grouped into one category. newer studies indicate the need to revise the current tnm system, since g ... | 2006 | 17168078 |
| carcinoma of the tongue base treated by transoral laser microsurgery, part one: untreated tumors, a prospective analysis of oncologic and functional outcomes. | to report the oncologic and functional outcomes of transoral laser microsurgery (tlm) in the management of untreated primary carcinoma of the tongue base. | 2006 | 17146388 |
| carcinoma of the tongue base treated by transoral laser microsurgery, part two: persistent, recurrent and second primary tumors. | to report the oncologic and functional outcomes of transoral laser microsurgery (tlm) in the treatment of persistent, recurrent, and second primary squamous cell carcinoma of the tongue base. | 2006 | 17146389 |
| diagnostic and therapy of locally advanced rectal cancer. | the aim of the study was to check the results of the protocol with neoadjuvant chemoirradiation for the treatment of locally advanced rectal cancer. the value of preoperative methods for staging of rectal cancer was also studied. in the period 1st of june 2000 - 31st of december 2005, 116 patients were included into the study, all with histologically proven rectal cancer up to 12 cm from anal verge and all with t3/t4 no-2 m0 stage. median follow up was 48 months. operability rate was 90,1%, loca ... | 2006 | 17139899 |
| [the quest of a project for the future: the national socialistic leading discipline psychiatry and its "crisis of legitimation"]. | when the national socialists came to power in 1933 psychiatry experienced a boom in germany that was undreamed-of. psychiatry became one of the leading disciplines because it put the theory of racial hygiene into practice, which was closely linked to the national socialists' ideology. coercive sterilizations performed in hundreds of thousands cases could only be carried out with the help of many deeply convinced psychiatrists. from the late 1930s on tables started to be turned: psychiatrists wer ... | 2006 | 17144372 |
| [age-related specificity of the blood picture in females with diffuse toxic goiter]. | the factor analysis was used to examine a relationship of a number of clinical and blood biochemical parameters to the level of triiodothyronine (t3), tyroxine (t4), and thyroid-stimulating hormone (tsh) in third-fourth degree diffuse toxic goiter (dtg) in females aged 17-45 and 46-58 years. it was established that the changes in t4 and tsh values were coordinated and t3 values varied independently. in dtg, the concentration of t4 correlated with that of k' and the levels of tsh and t4 correlate ... | 2006 | 17144544 |
| uncoupling of nucleotide flipping and dna bending by the t4 pyrimidine dimer dna glycosylase. | bacteriophage t4 pyrimidine dimer glycosylase (t4-pdg) is a base excision repair protein that incises dna at cyclobutane pyrimidine dimers that are formed as a consequence of exposure to ultraviolet light. cocrystallization of t4-pdg with substrate dna has shown that the adenosine opposite the 5'-thymine of a thymine-thymine (tt) dimer is flipped into an extrahelical conformation and that the dna backbone is kinked 60 degrees in the enzyme-substrate (es) complex. to examine the kinetic details o ... | 2006 | 17115714 |
| oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: impact of postirradiated pathologic downstaging on local recurrence and survival. | the purpose of this study was to determine the oncologic outcomes and clinical factors affecting survival in patients who underwent neoadjuvant chemoradiotherapy following tumor specific mesorectal excision for locally advanced, fixed rectal cancer. | 2006 | 17122629 |
| role of thyroid hormones, maternal antibodies, and antibody response in the susceptibility to colibacillosis of broiler genotypes. | the purpose of this study was to investigate whether differences in susceptibility to colibacillosis are associated with maternal antibodies, antibody response, and alterations in thyroid hormones [triiodothyronine (t3) and thyroxine (t4)] and to investigate the effect of genotype on the changes in t3 and t4 during challenge and antibody response. a challenge experiment was executed in 2 trials. per trial, 24 chicks per genotype were challenged, and 20 chicks per genotype were controls. at 7 d o ... | 2006 | 17135670 |
| free thyroxine, cognitive decline and depression in alzheimer's disease. | the role of thyroid function in alzheimer's disease (ad) has been subject to a number of studies during the last years. we investigated the possible relationship between plasma levels of the biologically active free form of thyroxin (ft4) and cognitive function in 227 outpatients with mild to moderate alzheimer s disease (ad) in a cross-sectional study design. a significant negative correlation was found between plasma ft4-levels and mini-mental state examination (mmse) score (spearman rho = -0. ... | 2006 | 17136019 |
| [useful and limits of the biochemical markers for the diagnosis of thyroid carcinoma]. | a series of biochemical parameters are useful for the diagnosis and follow-up of differentiated thyroid carcinomas. the measurement of serum thyroglobulin (tg) is considered for the post-surgical/radioiodine follow-up of papillary/follicular carcinomas. other than in basal conditions, the importance of tg levels during tsh stimulation is underlined, either by discontinuation of l-t4 therapy or by recombinant human tsh test. the finding of undetectable tg levels during tsh stimulation is highly c ... | 2006 | 17137035 |
| increase in skin temperature after spinal anesthesia in infants. | the relatively stable hemodynamics during spinal anesthesia in infants have been attributed to a less active sympathetic nervous system in comparison with adults. thus, the authors evaluated sympathetic block primarily by measurement of skin temperature and secondarily by determination of noninvasive blood pressure as an indirect sign of sympatholysis. | 2006 | 17138194 |
| fungal endophytes in potato roots studied by traditional isolation and cultivation-independent dna-based methods. | the composition and relative abundance of endophytic fungi in roots of field-grown transgenic t4-lysozyme producing potatoes and the parental line were assessed by classical isolation from root segments and cultivation-independent techniques to test the hypothesis that endophytic fungi are affected by t4-lysozyme. fungi were isolated from the majority of root segments of both lines and at least 63 morphological groups were obtained with verticillium dahliae, cylindrocarpon destructans, colletotr ... | 2006 | 17117985 |
| does cleome droserifolia have anti-schistosomiasis mansoni activity? | the present study was undertaken to assess the effect of the crude extract of cleome droserifolia (cd) leaves on experimentally infected mice with schistosoma mansoni. two groups of mice, showing a patent infection of s. mansoni, one of them was daily treated with an alcoholic extract of cd leaves (0.31 g kg-1 body weight, i.p.) for 21 days. the schistosomicidal activity of the cd extract was evaluated, three weeks post-treatment, on some parasitological and histopathological aspects including w ... | 2006 | 17119681 |
| species composition and structure of thysanoptera communities in different microhabitats at the parque estadual de itapuã, viamão, rs. | although thrips are known as inhabitants of flowers, they are also abundant and diverse in other microhabitats. there is an information gap concerning them, especially related to the native fauna in southern brazil. the structure and composition of the thysanopteran community in different microhabitats was studied at the "parque estadual de itapuã" (30 degrees 22' s 51 degrees 02' w), rs, southern brazil. between june 1999 and may 2001, branches (n = 1,274), flowers (n = 774), grass tussocks (n ... | 2006 | 17119824 |
| amiodarone-induced thyroid dysfunction in clinical practice. | amiodarone is a potent class iii anti-arrhythmic drug used in clinical practice for the prophylaxis and treatment of many cardiac rhythm disturbances, ranging from paroxismal atrial fibrillation to life threatening ventricular tachyarrhythmias. amiodarone often causes changes in thyroid function tests mainly related to the inhibition of 5'-deiodinase activity resulting in a decrease in the generation of t3 from t4 with a consequent increase in rt3 production and a decrease in its clearance. in a ... | 2006 | 17121321 |
| effect of thyroxine replacement on serum igf-i, igfbp-3 and the acid-labile subunit in patients with hypothyroidism and hypopituitarism. | to describe the effect of t4 replacement in patients with primary and central hypothyroidism on components of the igf binding protein complex: igf-i, the acid-labile subunit (als) and igfbp-3. | 2006 | 17121519 |
| origin and phylogeographical structure of chinese cattle. | complete mitochondrial d-loop sequences of 231 samples were used to explore the origin and genetic diversity of chinese cattle. phylogenetical analysis of these sequences revealed both bos taurus and bos indicus mitochondrial types in chinese cattle. four of the previously identified mitochondrial dna lineages (t1-t4) were identified in the bos taurus type, including lineage t1, which was found for the first time in chinese cattle. two lineages (i1 and i2) were identified in the bos indicus type ... | 2006 | 17121603 |
| combined spinal epidural does not cause a higher sensory block than single shot spinal technique for cesarean delivery in laboring women. | the combined spinal epidural (cse) technique has been shown to result in a higher sensory block than an equivalent single shot spinal (sss) in women undergoing elective cesarean delivery. we tested whether this is true also in laboring women who may have variable epidural pressures. | 2006 | 17122236 |
| [hormonal, auxological and clinical follow-up in children with connatal hiv infection: personal records]. | auxological and endocrinological complications frequently occur in children with connatal hiv infection. these complications seem to be related both to the infection itself and the antiretroviral therapy. many children consequently show height-weight and pubertal retardation without any evidence of hormonal deficit. we studied 10 children with connatal hiv infection who were enrolled in this analysis and followed up for 7 years in order to evaluate their height-weight growth, pubertal maturation ... | 2006 | 17127827 |
| endocrinology update 2006. | endocrinology has recently witnessed several important developments: the epidemiology of diabetes interventions and complications study, a follow-up to the landmark diabetes control and complications trial, found that strict glucose control early in the course of type 1 diabetes reduces the risk of microvascular and cardiovascular complications and provides prolonged benefits even if intensive control is not so tightly maintained. inhaled insulin preparations are now available for mealtime cover ... | 2006 | 17128544 |
| fabrication and characterization of rna aptamer microarrays for the study of protein-aptamer interactions with spr imaging. | rna microarrays were created on chemically modified gold surfaces using a novel surface ligation methodology and employed in a series of surface plasmon resonance imaging (spri) measurements of dna-rna hybridization and rna aptamer-protein binding. various unmodified single-stranded rna (ssrna) oligonucleotides were ligated onto identical 5'-phosphate-terminated ssdna microarray elements with a t4 rna ligase surface reaction. a combination of ex situ polarization modulation ftir measurements of ... | 2006 | 17130155 |
| activation of regb endoribonuclease by s1 ribosomal protein requires an 11 nt conserved sequence. | the t4 regb endoribonuclease cleaves specifically in the middle of the -ggag- sequence, leading to inactivation and degradation of early phage mrnas. in vitro, regb activity is very weak but can be enhanced 10- to 100-fold by the escherichia coli ribosomal protein s1. not all rnas carrying the ggag motif are cleaved by regb, suggesting that additional information is required to obtain a complete regb target site. in this work, we find that in the presence of s1, the regb target site is an 11 nt ... | 2006 | 17130171 |
| expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma. | to investigate the clinical and pathological significance of altered retinoblastoma (rb) encoding protein (prb) in gastric carcinoma. | 2006 | 17131485 |
| [ileovesical fistula caused by bladder cancer with bladder stone]. | enterovesical fistula is a very rare complication of primary urological malignancies. a case of ileovesical fistula caused by a bladder carcinoma is presented. a 66-year-old male was referred with complaints of urinary pain. on admission, fecaluria and urinary tract infection with bladder stone were detected. cystography revealed the passage of contrast medium into the small bowel. under the diagnosis ofileovesical fistula due to suspected inflammatory disease, sigmoidectomy and segmental small ... | 2006 | 17131870 |
| thyroid hormone resistance. | resistance to thyroid hormone (rth) is a rare autosomal dominant inherited syndrome of reduced end-organ responsiveness to thyroid hormone. patients with rth have elevated serum free thyroxine (ft4) and free triiodothyronine (ft3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (tsh) level. despite a variable clinical presentation, the common characteristic clinical features are goitre but an absence of the usual symptoms and metabolic consequences of thyroid hor ... | 2006 | 17132274 |
| thyroid function in patients with alzheimer disease: implications on response to anticholinesterase treatment. | increasing evidence supports an extensive interrelationship between thyroid hormones and the cholinergic system, which is selectively and early affected in alzheimer disease (ad). the aim of the present study was to explore thyroid function in patients with ad before and after acetylcholinesterase inhibition treatment to possibly identify variances in response. thyroid function tests were evaluated in 28 ad patients and 24 age and sex-matched controls. nineteen of the patients were reevaluated a ... | 2006 | 17132968 |
| comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers. | to evaluate the relative bioavailability of t4 sodium and liothyronine sodium (t3), administered in single doses as oral solution (drops) and tablet forms, according to two separate study protocols. | 2006 | 17259789 |
| [expression of survivin in nasal and paranasal sinus carcinoma]. | to assess the protein expression of a new inhibitor of apoptosis, survivin, and its correlation with spontaneous apoptosis, tumor clinicopathological parameters and prognosis in nasal and paranasal sinus carcinoma (npsc). | 2006 | 17283539 |
| [surgery treatment of rectal cancer]. | surgical resection is the only curative procedure for carcinoma of the rectum. heald's development of total mesorectal excision has made it the standard approach for mobile, non-fixed tumors; it permits optimal local control with less than 10% local recurrence at five years and minimizes nerve damage and genito-urinary complications. although initial short-term results of laparoscopic approaches are very promising, the final role of laparoscopy has not yet been established. neo-adjuvant radiothe ... | 2006 | 17285082 |
| the effect of life-long thyroxine treatment and physical activity on bone mineral density in young adult women with congenital hypothyroidism. | normalization of plasma thyrotropin in t4-supplemented patients with thyroidal congenital hypothyroidism (ch) requires elevated plasma ft4-concentrations compared to patients with acquired thyroidal hypothyroidism. we investigated bone mineral density (bmd) in patients with ch. | 2006 | 17252693 |