Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats. | thyroid dysfunction produces marked cardiovascular responses. hypothyroidism and hyperthyroidism cause important changes in the circulating renin-angiotensin system (ras). modifications in cardiac ras have also been involved in cardiovascular alterations. studies have revealed that thyroid hormones activate some components of cardiac ras. angiotensin (ang) peptides are regulated by the activity of several aminopeptidases (ap) called angiotensinases. previous results in our laboratory have demons ... | 2006 | 17031265 |
| effects of chronic angiotensin ii receptor antagonist and angiotensin-converting enzyme inhibitor treatments on neurohormonal levels and haemodynamics during cardiopulmonary bypass. | chronic treatment with renin-angiotensin system (ras) antagonists frequently causes deleterious hypotension during anaesthesia. we compared the effects of angiotensin ii receptor antagonists (ara) and angiotensin-converting enzyme inhibitors (acei) on neurohormonal levels and haemodynamics during cardiopulmonary bypass (cpb). | 2006 | 17032660 |
| hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin. | corticosteroid-binding globulin (cbg) is a plasma glycoprotein that is primarily synthesized in the liver and binds cortisol and progesterone with high affinity. in this study, a cbg secreting hepatocellular carcinoma derived cell line (hepg2) was used to investigate the hormonal regulation of hepatic cbg synthesis. hepg2 cells were grown for 72 h in 30, 300 and 3000 nm concentrations of estradiol (e2), testosterone (t), insulin, thyroxin (t4) and dexamethasone (dmz) and the secreted cbg quantif ... | 2006 | 17029948 |
| long-term outcome of thyroid function after amiodarone-induced thyrotoxicosis, as compared to subacute thyroiditis. | two main forms of amiodarone- induced thyrotoxicosis (ait) exist: type 1 ait is a condition of true hyperthyroidism developing in patients with pre-existing thyroid disorders, and usually requires thyroid ablative treatment. on the other hand, type 2 ait is a form of destructive thyroiditis occurring in normal thyroids, the management of which usually consists in glucocorticoid treatment. | 2006 | 17033257 |
| the role of n-acetylcysteine in lower extremity ischemia/reperfusions. | to evaluate the efficacy of n-acetyl cysteine (nac) in lower extremity ischemia/reperfusion. | 2006 | 17033604 |
| assessment of thoracic epidural analgesia during general anesthesia using pupillary reflex dilation: a preliminary study. | pupillary reflex dilation (prd) secondary to noxious stimulation accurately predicts sensory block during combined lumbar epidural/general anesthesia. therefore, the adequacy of prd-guided thoracic epidural infusion during general anesthesia for thoracotomy was studied. | 2006 | 17023285 |
| phase ii trial of preoperative chemoradiation with a hyperfractionated radiation boost in locally advanced rectal cancer. | the purpose of this phase ii study was to prospectively determine the efficacy of preoperative chemoradiation with a hyperfractionated (hfx) rt boost to 61.8 gy in locally advanced rectal cancer. | 2006 | 17023775 |
| adjacent level load transfer following vertebral augmentation in the cadaveric spine. | in vitro biomechanics. | 2006 | 17023840 |
| the importance of classification in sympathetic surgery and a proposed mechanism for compensatory hyperhidrosis: experience with 464 cases. | compensatory hyperhidrosis is the most troublesome side effect and the leading cause of regret with sympathetic surgery. a new classification is proposed to make the procedure more selective and to minimize the side effects and regret rate. also, a proposed mechanism for compensatory hyperhidrosis is discussed. | 2006 | 17024534 |
| intermittent hormone therapy in nonmetastatic prostate cancer. | the object of this study was to evaluate the duration of response to intermittent androgen deprivation (iad) in patients with nonmetastatic recurrent or localized prostate cancer. | 2006 | 17026802 |
| phase ii trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer. | despite the general acceptance of gemcitabine/cisplatin in metastatic bladder cancer, its role and tolerability in the adjuvant setting, in which renal insufficiency is common, is unclear. | 2006 | 17026804 |
| comparison of the internal dynamics of globular proteins in the microcrystalline and rehydrated lyophilized states. | natural abundance solid-state 13c-nmr spin-lattice relaxation experiments in the laboratory (t1) and off-resonance rotating (t(1rho)) frames were applied for qualitative comparison of the internal molecular dynamics of barstar, hen egg white lysozyme and bacteriophage t4 lysozyme in both the microcrystalline and the rehydrated (water content is 50% of the protein mass) lyophilized states. the microcrystalline state of proteins provides a better spectral resolution; however, less is known about t ... | 2006 | 17027351 |
| do erythropoietin receptors on cancer cells explain unexpected clinical findings? | recent reports suggest that cancer control may worsen if erythropoietin is administered. we investigated whether erythropoietin receptor expression on cancer cells may correlate with this unexpected finding. | 2006 | 17028293 |
| double-strand break repair in bacteriophage t4: recombination effects of 3'-5' exonuclease mutations. | the role of 3'-5' exonucleases in double-strand break (dsb)-promoted recombination was studied in crosses of bacteriophage t4, in which dsbs were induced site specifically within the riib gene by segc endonuclease in the dna of only one of the parents. frequency of rii+ recombinants was measured in two-factor crosses of the type i x ets1, where ets1 designates an insertion in the riib gene carrying the cleavage site for segc and i's are riib or riia point mutations located at various distances ( ... | 2006 | 17028319 |
| addition of right lateral decubitus positioning improves vertebral visualization with vfa in selected patients. | densitometric vertebral fracture assessment (vfa) allows detection of clinically unappreciated vertebral fracture. however, vertebral visualization using vfa can be suboptimal. in such individuals, alternative spine positioning may enhance visualization. consistent with this, we observed that reversal of positioning (right lateral decubitus rather than standard left lateral decubitus, subsequently referred to as "reverse" positioning) improved visualization in patients with suboptimal vertebral ... | 2006 | 16931359 |
| the prognostic value of severe malnutrition in the development of nonthyroidal illness in head and neck cancer patients. | thyroid hormone metabolism is modulated by starvation and overfeeding but also by dietary composition. unfortunately, little is known about the effect of malnutrition on disease-induced nonthyroidal illness (nti). in this study, we investigated whether the degree of nti after surgery differed between severely malnourished and well-fed patients with head and neck cancer. | 2006 | 16931610 |
| clinical utility of measurements of insulin-like growth factor 1. | plasma insulin-like growth factor 1 (igf-i) concentrations are regulated by genetic factors, nutrient intake, growth hormone (gh) and other hormones such as t4, cortisol and sex steroids. the accuracy of igf-i measurement in diagnosing gh deficiency or excess depends, in part, on the relative contributions of each of these variables. since their respective influence may vary widely between individuals, the establishment of well-defined normal ranges is necessary, which requires adequate numbers ... | 2006 | 16932333 |
| oxidative stress during 1-lung ventilation. | resuming 2-lung ventilation from 1-lung ventilation might induce a re-expansion and reoxygenation effect. the oxidative stress during 1-lung ventilation/2-lung ventilation has not been studied, although severe complications, such as re-expansion pulmonary edema, were reported. reactive oxygen species production and total antioxidant status assay levels were measured in this study during 1-lung ventilation/2-lung ventilation. the effects on extravascular lung water, cardiac output, and intrathora ... | 2006 | 16935103 |
| effect of l-thyroxine treatment on left ventricular function in subclinical hypothyroidism. | aim of this study was to investigate the effects of thyroxine treatment on myocardial regional left ventricular (lv) systolic and diastolic function in patients with subclinical hypothyroidism (sh) by tissue doppler imaging (tdi). forty-two patients (29 women and 13 men; mean age 52.2+/-15.1 years) with sh, as judged by elevated serum thyroid-stimulating hormone (tsh) levels (>3.6 miu/l; range, 3.8-12.0) and free thyroid hormones (ft4 and ft3) within the normal range, and 30 euthyroid volunteers ... | 2006 | 16935462 |
| regulation of type iii iodothyronine deiodinase expression in human cell lines. | type i iodothyronine deiodinase (d1) and type ii iodothyronine deiodinase (d2) catalyze the activation of the prohormone t4 to the active hormone t3; type iii iodothyronine deiodinase (d3) catalyzes the inactivation of t4 and t3. d3 is highly expressed in brain, placenta, pregnant uterus, and fetal tissues and plays an important role in regulating thyroid hormone bioavailability during fetal development. we examined the activity of the different deiodinases in human cell lines and investigated t ... | 2006 | 16935842 |
| [clinical and muscular evaluation in patients with subclinical hypothyroidism]. | some symptoms and signs of hypothyroidism, as well as some laboratory abnormalities, may be present in subclinical hypothyroidism (sh). this study evaluates the prevalence of signs and symptoms of hypothyroidism and skeletal muscle dysfunction in 57 patients with sh compared to 37 euthyroid controls. the participants received a clinical score based on signs and symptoms of hypothyroidism. the muscle strength was estimated by manual testing and chair dynamometer and inspiratory force by manuvacuo ... | 2006 | 16936994 |
| relations among mothers' expressivity, children's effortful control, and their problem behaviors: a four-year longitudinal study. | longitudinal relations between mothers' expressivity, children's effortful control, and their problem behaviors were examined when children (n = 181) were 6.5-10 years old (t2) and again 2 (t3) and 4 (t4) years later. mothers reported on their expression of positive and negative dominant emotion. mothers and teachers reported on children's effortful control and externalizing and internalizing problem behaviors. in structural equation models, variables exhibited consistency over time. further, th ... | 2006 | 16938087 |
| rna chaperone activity of translation initiation factor if1. | translation initiation factor if1 is an indispensable protein for translation in prokaryotes. no clear function has been assigned to this factor so far. in this study we demonstrate an rna chaperone activity of this protein both in vivo and in vitro. the chaperone assays are based on in vivo or in vitro splicing of the group i intron in the thymidylate synthase gene (td) from phage t4 and an in vitro rna annealing assay. if1 wild-type and mutant variants with single amino acid substitutions have ... | 2006 | 16938378 |
| leptin acute modulation of the 5'-deiodinase activities in hypothalamus, pituitary and brown adipose tissue of fed rats. | leptin and thyroid hormones (th) have the ability to increase energy expenditure. biological effects of th are dependent on thyroxine (t4) to triiodothyronine (t3) conversion by deiodinase type 1 (d1) and type 2 (d2). leptin has been shown to stimulate the hypothalamus-pituitary-thyroid axis and, also, to modulate 5'-deiodinases in different tissues, depending on energetic status of animals. here, we examined the acute effects of leptin on hypothalamic, pituitary and bat d2 and pituitary d1 acti ... | 2006 | 16941271 |
| response of four types of coliphages to high hydrostatic pressure. | pressure inactivation of four types of coliphages, varphix 174 (ssdna virus), ms2 (ssrna virus), lambda imm434 (dsdna virus) and t4 (dsdna virus), was studied to evaluate their potential as human enteric viral surrogates for use in validation of commercial pressure processing treatments. phage varphix 174 demonstrated an unexpected high resistance to pressure with no more than 1-log(10) reduction observed following exposures to 350-600 mpa. there was no greater than 1-log(10) reduction below 500 ... | 2006 | 16943050 |
| [tc]-99m thyroid scintigraphy in congenital hypothyroidism screening program. | the aetiology of congenital hypothyroidism (ch) may be important in determining disease severity, outcome and treatment schedules because athyroid patients need higher treatment doses and close monitoring particularly early in life. the aim of this study was to evaluate thyroid scintigraphy (ts) findings in infants with ch and to determine the relationship of serum tsh and t4 values with thyroid agenesia, in an attempt to identify factors that may detect thyroid agenesia before treatment. since ... | 2006 | 16943215 |
| [anterolateral thigh perforator flaps for facial reconstruction after tumour surgery]. | individual flap design and minor donor site morbidity are main criteria in the treatment of facial defects after tumour surgery. microvascular perforator flaps seem to follow these criteria well. in the following study our experiences with microvascular anterolateral thigh perforator flaps (altpf) in reconstruction of the face following ablative tumour surgery are described and discussed in comparison to the present literature. | 2006 | 16944084 |
| a biomechanical analysis of sublaminar and subtransverse process fixation using metal wires and polyethylene cables. | an in vitro biomechanical calf thoracic spine study. | 2006 | 16946654 |
| neuromodulatory role of 5-hydroxytryptamine type 1a receptors on the excitability of renshaw cells in the rat spinal cord. | serotonin modulates neurotransmission at synapses between various spinal neurons and, thus, may either facilitate or depress the information processed in the circuits and ultimately modulate the final motor output. a possible neuromodulatory role of 5-hydroxytryptamine type 1a (5-ht1a) receptors on the excitability of lumbar spinal renshaw cells was explored in anesthetized rats spinalized at t4 level. intravenous administration of the specific 5-ht1a agonist (2r)-(+)-8-hydroxy-2-(di-n-propylami ... | 2006 | 16951575 |
| early activation of an altered thyroid hormone profile in asymptomatic or mildly symptomatic idiopathic left ventricular dysfunction. | although an altered thyroid metabolism has been documented in patients with overt heart failure, no evaluation has been made of a heart-thyroid interaction in mildly symptomatic patients with idiopathic left ventricular dysfunction (ilvd). we wanted to assess the thyroid state in patients with ilvd. | 2006 | 16952785 |
| ectopic fascioliasis in the dorsal spine: case report. | parasitic myelopathy is rare. we report ectopic infestation of the spine by fasciola hepatica. | 2006 | 16955027 |
| degradability of dimethyl terephthalate by variovorax paradoxus t4 and sphingomonas yanoikuyae dos01 isolated from deep-ocean sediments. | two strains of bacteria were isolated from deep-ocean sediments of the south china sea using enrichment culturing technique and they were identified as sphingomonas yanoikuyae dos01 (ay878409) and variovorax paradoxus t4 (ay878410) based on 16s rrna gene sequences. s. yanoikuyae dos01 was only capable of transforming dimethyl terephthalate (dmtp) to monomethyl terephthalate (mmtp) without further degradation while v. paradoxus t4 exhibited ability in mineralizing dmtp as the sole source of carbo ... | 2006 | 16955363 |
| [endemic goiter and iodine deficiency: are they still a reality in spain]. | to estimate the prevalence of goiter and iodine deficiency in a health district in the autonomous community of valencia, given the absence of data in this region of spain. | 2006 | 16956503 |
| association and dissociation of the cell puncturing complex of bacteriophage t4 is controlled by both ph and temperature. | the tail lysozyme, gp5, of bacteriophage t4 is a trimeric protein and all the subunits are nicked between ser351 and ala352 during assembly through processing. when subsequently heated, the resulting (gp5*)(3) (gp5c)(3) (the asterisk "*" denotes that the intact pre-gp5 trimer has been nicked) dissociates into three gp5* (three independent n-terminal monomeric peptides, that carry lysozyme moieties at the c-termini of gp5*), and a c-terminal trimeric beta-helical structure (gp5c)(3). the interact ... | 2006 | 16956798 |
| thyroid function and morphology after a successful kidney transplantation. | although thyroid disorders related to the end-stage renal disease (esrd) are well known, there are discordant data on the function and morphology of the thyroid gland after renal transplantation (rt). the objective of this cross-sectional, case-control study was to investigate the prevalence and risk factors for disorders in the thyroid function and morphology after a successful rt. fifty consecutive patients (25 females, 25 males) with fully functioning allograft were enrolled. their age at tra ... | 2006 | 16957411 |
| rifampin-induced hypothyroidism. | three euthyroid patients with hashimoto's thyroiditis developed hypothyroidism after the administration of rifampin. we studied 67 patients with tuberculosis. all of them were treated with rifampin. of the 67 patients, 42 had negative tests for anti-thyroid antibodies (ata) and 25 had positive tests for ata. the diagnosis of hashimoto's thyroiditis was made on the basis of positive tests for ata. after the administration of rifampin, tsh levels were not significantly altered in all of the former ... | 2006 | 16957414 |
| mechanisms of disease: psychomotor retardation and high t3 levels caused by mutations in monocarboxylate transporter 8. | the actions and the metabolism of thyroid hormone are intracellular events that require the transport of iodothyronines across the plasma membrane. it is increasingly clear that this process does not occur by simple diffusion, but is facilitated by transport proteins. only recently have iodothyronine transporters been identified at the molecular level, of which organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 (mct8) deserve special mention, because of their high activ ... | 2006 | 16957765 |
| tsh-induced hyperthyroidism caused by a pituitary tumor. | a 45-year-old man presented with frontal headache and visual disturbances to our clinic. for the previous 5 years, he had been receiving treatment for long-lasting mild hyperthyroidism with antithyroid therapy, but therapy had not been carefully followed. during the last 2 years he had also complained of erectile dysfunction and loss of libido. on physical examination, he had a small goiter, normal skin, no graves' ophthalmopathy, normal bmi, and reduced testis volume and pubic hair. | 2006 | 16957766 |
| molecular interactions involving escherichia coli nucleoside diphosphate kinase. | nucleoside diphosphate kinase plays a distinctive metabolic role as the enzyme poised between the last reaction of deoxyribonucleoside triphosphate (dntp) biosynthesis and the dna polymerization apparatus. in bacteriophage t4 infection, ndp kinase is one of very few enzymes of host cell origin to participate in either dntp synthesis or dna replication. yet ndp kinase forms specific contacts with phage-coded proteins of dntp and dna synthesis. this article summarizes work from our laboratory that ... | 2006 | 16957984 |
| [investigation of relationship between prehospital care for traumatic shock and postoperative acute lung injury/acute respiratory distress syndrome]. | to investigate and analyze the correlation and clinical significance of prehospital treatment for traumatic shock and postoperative acute lung injury (ali)/acute respiratory distress syndrome (ards). | 2006 | 16959149 |
| esophageal cancer: determination of internal target volume for conformal radiotherapy. | to evaluate esophageal tumor and oar movement during the respiratory cycle in order to obtain optimal values for itv and prv. to correlate tumor motion with chest wall displacement - information of value in the free-breathing gating system. | 2006 | 16959345 |
| developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term. | preterm infants have low serum t4 and t3 levels, which may partly explain the immaturity of their tissues. deiodinase enzymes are important in determining the bioavailability of thyroid hormones: deiodinases d1 and d2 convert t4 to t3, whereas deiodinase d3 inactivates t3 and produces rt3 from t4. in human and ovine fetuses, plasma t3 rises near term in association with the prepartum cortisol surge. this study investigated the developmental effects of cortisol and t3 on tissue deiodinases and pl ... | 2006 | 16959839 |
| emerging trends in dual energy x-ray absorptiometry. | the risk of osteoporosis and cardiovascular disease increase significantly with age. because of the long silent latency of these diseases, there is the opportunity for primary prevention before clinical symptoms occur. the newer fan beam dual energy x-ray absorptiometry (dxa) systems can detect vertebral fractures with fast, low dose lateral scans of the vertabrae from t4 to l4 in as little as 10 s. the next generation of dxa imaging technology will image the hip in 3d and is expected to give a ... | 2006 | 16922127 |
| is it safe to treat hyperthyroid patients with i-131 without fear of thyroid storm? | thyroid storm is extremely rare. however, hyperthyroid patients with severe thyrotoxicosis are frequently not treated immediately with i-131 for fear of thyroid storm but are placed on thiouracil drugs for varying periods of time. we demonstrate herein that it is safe to treat these patients with 1-131, without pretreatment with thiouracil drugs, provided they do not have complicating intercurrent disease. our definition of severe hyperthyroidism includes marked signs and symptoms of thyrotoxico ... | 2006 | 16922465 |
| clinical importance of technetium-99m-methoxyisobutylisonitrile (mibi) scintigraphy in differentiated thyroid carcinoma patients with elevated thyroglobulin levels and negative i-131 scanning results. | the aim of this study was to evaluate the potential contribution of tc-99m-mibi scintigraphy to the follow-up of patients with differentiated thyroid carcinoma, who had elevated tg levels and negative i-131 whole-body scan results. | 2006 | 16922467 |
| polymerase chain reaction-based denaturing gradient gel electrophoresis in the evaluation of oral microbiota. | clinical evaluation of oral microbial reduction after a standard prophylactic treatment has traditionally been based on bacterial cultivation methods. however, not all microbes in saliva or dental plaque can be cultivated. polymerase chain reaction-based denaturing gradient gel electrophoresis (pcr-dgge) is a cultivation-independent molecular fingerprinting technique that allows the assessment of the predominant bacterial species present in the oral cavity. this study sought to evaluate the oral ... | 2006 | 16922934 |
| prevalence of chronic autoimmune thyroiditis in the urban area neighboring a petrochemical complex and a control area in sao paulo, brazil. | to evaluate the prevalence of chronic autoimmune thyroiditis in 2 urban areas of metropolitan são paulo (brazil): polo area neighboring a large petrochemical complex and são bernardo campo area (control area). | 2006 | 16924321 |
| effect of conjugated equine estrogens and tamoxifen administration on thyroid gland histomorphology of the rat. | the aim of this study was to evaluate the action of the conjugated equine estrogens and tamoxifen on the morphology of thyroid gland in ovariectomized (ovx) rats. | 2006 | 16924323 |
| [construction of recombinant gst-rcas1 fusion gene and its expression in e. coli]. | to construct the recombinant plasmid of rcas1, to express and purify its fusion protein gst-rcas1, and to investigate its biological function. | 2006 | 16924700 |
| the expression of prostate stem cell antigen in human clear cell renal cell carcinoma: a quantitative reverse transcriptase-polymerase chain reaction analysis. | to analyse the gene expression level of prostate stem cell antigen (psca) in human clear cell renal cell carcinoma (cc-rcc) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of psca on the progression of cc-rcc. | 2006 | 16925770 |
| a huge posteromedial mediastinal cyst complicated with vertebral dislodgment. | mediastinal cysts compromise almost 20% of all mediastinal masses with bronchogenic subtype accounting for 60% of all cystic lesions. although compression of adjoining soft tissues is usual, spinal complications and neurological symptoms are outmost rare and tend to characterize almost exclusively the neuroenteric cysts. | 2006 | 16925804 |
| small gene effect and exercise training-induced cardiac hypertrophy in mice: an ace gene dosage study. | small gene effects influence complex phenotypes in a context dependent manner. here we evaluated whether increasing dosage of the angiotensin i converting enzyme (ace) gene influence exercise-induced cardiac hypertrophy. mice harboring one, two, three, and four copies of the ace gene were assigned to sedentary (s1-4) and swimming exercise-trained (t1-4) groups (1.5 h twice daily, 5 days/wk, 4 wk). exercising resulted in comparable bradycardia and elevated skeletal muscle citrate synthase activit ... | 2006 | 16926272 |
| [inhibition of integrin beta1 expression in human keratinocyte stem cells by vector-1 based interfering rna strategy]. | to investigate the influence of integrin beta1 on the proliferation and differentiation of human keratinocyte stem cells (kscs). | 2006 | 16964653 |
| analysis of physical and mental development of children with aplasia, hypoplasia and ectopy of the thyroid gland. | evaluation of clinical and biochemical differences between various forms of thyroid dysgenesia in children. | 2006 | 16964962 |
| safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase i study. | broccoli sprouts are widely consumed in many parts of the world. there have been no reported concerns with respect to their tolerance and safety in humans. a formal phase i study of safety, tolerance, and pharmacokinetics appeared justified because these sprouts are being used as vehicles for the delivery of the glucosinolate glucoraphanin and its cognate isothiocyanate sulforaphane [1-isothiocyanato-(4r)-(methylsulfinyl)butane] in clinical trials. such trials have been designed to evaluate prot ... | 2006 | 16965241 |
| treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: a rare cancer network study. | this rare cancer network (rcn) study was performed in pediatric nasopharyngeal carcinoma (pnpc) patients to evaluate the optimal dose of radiotherapy and to determine prognostic factors. | 2006 | 16965827 |
| long-term outcome of patients treated by radiation therapy alone for salivary gland carcinomas. | to review a single-institution experience with the management of salivary gland cancers treated by radiation alone. | 2006 | 16965870 |
| [interhemisphere differences of extrastriate cortical activation during attention and selection of lateralized visual stimuli in humans]. | the cortical activation was estimated by event-related potentials (erps) methods during selection tasks of lateralized visual stimuli in right and left hemi-fields requiring different forms of attention: 1. attention of a stimuli form, 2. attention of a stimuli position, 3. combined attention of form and position. erps were recorded in 15 young healthy adults in 6 leads: p3, p4, t3, t4, t5, t6 and endogenous erps components: cnv (contingent negative variation), n1, p3 and complex [n1--p3]. the d ... | 2006 | 16967868 |
| transfer of surface polymerase reaction products to a secondary platform with conservation of spatial registration. | here, we describe a method for directly transferring very small amounts of reaction products from one surface to another. the approach is illustrated using a t4 dna polymerase reaction to extend primers hybridized to a surface-confined dna template. following the extension reaction, the resulting oligonucleotide is transferred to a product surface. the important results are that (1) the spatial registration of the product is preserved after transfer; (2) the same reactant surface can be used to ... | 2006 | 16967951 |
| atomically detailed simulations of concentrated protein solutions: the effects of salt, ph, point mutations, and protein concentration in simulations of 1000-molecule systems. | an ability to accurately simulate the dynamic behavior of concentrated macromolecular solutions would be of considerable utility in studies of a wide range of biological systems. with this goal in mind, a brownian dynamics (bd) simulation method is reported here that allows systems to be modeled that comprise in excess of 1000 protein molecules, all of which are treated in atomic detail. intermolecular forces are described in the method using an energy function that incorporates electrostatic an ... | 2006 | 16967959 |
| far field thermal radiation through nanoholes and apertures. | thermal radiation through a nanohole or a nanoaperture is calculated in this paper. results show that for aperture size << dominant wavelength of thermally excited photons, heat flux deviates significantly from the well-known planck blackbody expression of sigmat4, where sigma is the stefan-boltzmann constant and t is the temperature. the heat flux through a nanohole is proportional to t8 and a4, where a is the radius of the hole. finally it is shown that for at < 10(6), where a is expressed in ... | 2006 | 16968039 |
| hormonal change and cytokine mrna expression in peripheral blood mononuclear cells during the development of canine autoimmune thyroiditis. | to elucidate the hormonal change and alteration in cytokine expression in peripheral blood mononuclear cells (pbmc) during the early stage of autoimmune thyroiditis, we have developed a canine model of this disease, in which normal dogs were immunized with bovine thyroglobulin (tg) and/or canine thyroid extract. serum samples were collected weekly, anti-canine tg antibody was measured by enzyme-linked immunosorbent assay (elisa) and thyroid stimulating hormone (tsh) and total t4 levels by radioi ... | 2006 | 16968404 |
| influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype. | both genetic and environmental factors contribute to susceptibility to graves' disease (gd) and hashimoto's thyroiditis (ht), as well as disease manifestations. | 2006 | 16968788 |
| positron emission tomography reveals correlations between brain metabolism and mood changes in hyperthyroidism. | hyperthyroidism is frequently associated with emotional distress. the underlying cerebral processes of the endocrine-induced mood changes are unclear. | 2006 | 16968792 |
| [long-term results of chemoradiation therapy for the patients with locally advanced (t4) esophageal cancer]. | the prognosis of patients with advanced esophageal cancer is still poor. recently, concurrent chemoradiation therapy for esophageal cancer is being utilized with increasing frequency. in this study, we reported concurrent chemoradiation for patients with t4 esophageal cancer. from july 2000, we treated 21 consecutive patients with radiation and concurrent chemotherapy using intermittent low-dose fp chemoradiation (40 gy radiation, 2 gy/day, for 4 weeks 280/m(2) 5-fu intermittent 24 continuous, c ... | 2006 | 16969020 |
| prospective study of [18f]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. | to assess the clinical usefulness of [(18)f]fluorodeoxyglucose positron emission tomography ([18f]fdg pet) as well as computed tomography (ct) or magnetic resonance imaging (mri) in oral squamous cell carcinoma (scc) patients with palpably negative neck. | 2006 | 16983105 |
| an rna ligase-mediated method for the efficient creation of large, synthetic rnas. | rna ligation has been a powerful tool for incorporation of cross-linkers and nonnatural nucleotides into internal positions of rna molecules. the most widely used method for template-directed rna ligation uses dna ligase and a dna splint. while this method has been used successfully for many years, it suffers from a number of drawbacks, principally, slow and inefficient product formation and slow product release, resulting in a requirement for large quantities of enzyme. we describe an alternati ... | 2006 | 16983143 |
| effect of methimazole treatment for 2 years on circulating il-4, ige, tbii, and tsab in patients with hyperthyroid graves' disease. | in this study we confirmed our previous findings on the importance of ige in graves' disease and further investigated the relationships existing among graves' disease, ige, and interleukin-4. two hundred and thirty-two newly diagnosed graves' disease patients were treated with methimazole for 2 years, and were classified into 3 groups according to their response to the therapy. incidence of ige elevation (ige> or =170 iu/ml) before treatment was lowest, 23.8%, in the group who achieved remission ... | 2006 | 16983180 |
| long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. | neoadjuvant chemoradiotherapy does not alter anal sphincter preservation or postoperative complications compared with short-course radiotherapy alone in patients with clinical stage t3 or t4 resectable rectal cancer. the aim of this study was to compare survival, local control and late toxicity in the two treatment groups. | 2006 | 16983741 |
| management of amiodarone-induced thyrotoxicosis in latin america: an electronic survey. | to assess diagnostic and therapeutic approaches to amiodarone-induced thyrotoxicosis (ait) among members of the latin american thyroid society (lats). | 2006 | 16984234 |
| searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy. | understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. although methods have been developed for predicting potential effects of amino acid substitutions using sequence, three-dimensional structural, and evolutionary properties of proteins, the applications are limited by the complication of the features and the availability of protein structural information. another limitation is that the prediction results ar ... | 2006 | 16984653 |
| dna unwinding by escherichia coli dna helicase i (trai) provides evidence for a processive monomeric molecular motor. | the f plasmid trai protein (dna helicase i) plays an essential role in conjugative dna transfer as both a transesterase and a helicase. previous work has shown that the 192-kda trai protein is a highly processive helicase, catalytically separating >850 bp under steady-state conditions. in this report, we examine the kinetic mechanism describing dna unwinding of trai. the kinetic step size of trai was measured under both single turnover and pre-steady-state conditions. the resulting kinetic step- ... | 2006 | 16984922 |
| a 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in wistar rats. | a 28-day repeated dose study in rats (oecd407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (hbcd). rats were exposed by daily gavage to hbcd dissolved in corn oil in 8 dose groups with doses ranging between 0 and 200 mg/kg bw per day (mkd). evaluation consisted of dose-response analysis with calculation of a benchmark dose at the lower 95% one-sided confidence bound (bmdl) at predefined critical effect sizes (cess) of 10-20%. the most remarkable finding ... | 2006 | 16984958 |
| analysis of preexistent vertebral rotation in the normal quadruped spine. | in this ct study, vertebral rotation was analyzed in the transverse plane of the normal, nonscoliotic canine spine with a computer-based measurement method. | 2006 | 16985444 |
| increasing expression of fascin in renal cell carcinoma associated with clinicopathological parameters of aggressiveness. | to determine whether higher expression of fascin, an actin-bundling protein associated with motility, in conventional renal cell carcinoma (rcc) is associated with more advanced stages of the disease. | 2006 | 16977579 |
| responses of thyroid hormones of market-size broilers to thermoneutral constant and warm cyclic temperatures. | this study characterizes the responses, particularly diurnal variations, of thyroid hormones (th) [3,5,3'-triiodothyronine (t3), thyroxine (t4), and t3:t4 ratio (t3/t4)] of arbor acres broilers to constant thermoneutral (tn) or warm cyclic (wc) temperatures. there existed distinct circadian variations--2 peaks in th under the tn and wc conditions. the 2 peaks of t3, t4, and t3/t4 of the broilers occurred, respectively, at 0 and 16 h, 8 and 16 h, and 0 and 12 h under the tn condition; but at 0 an ... | 2006 | 16977836 |
| characterization and gene expression profiling of five new human embryonic stem cell lines derived in taiwan. | many human embryonic stem cell (hesc) lines have been reported, but only a few of them have been fully characterized. in this report, five new hesc lines were derived from 32 discarded blastocysts in taiwan, and these lines were continuously cultured on mitotically inactivated mouse embryonic fibroblast (mef) feeder layer in the hesc medium for more than 44 passages and underwent freezing/thawing processes. all five hesc lines expressed characteristic undifferentiated hesc markers, such as ssea- ... | 2006 | 16978057 |
| increasing emmprin and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters. | to examine the expression of extracellular matrix metalloprotease inducer (emmprin) and matriptase in hepatocellular carcinoma (hcc) and to correlate this with tumour progression. | 2006 | 16978202 |
| pyrolysis-field ionization mass spectrometry of rhizodeposits - a new approach to identify potential effects of genetically modified plants on soil organisms. | the objectives of the present study were (1) to investigate the qualitative composition of rhizodeposits leached from soils cropped with non-transgenic and genetically modified (gm) potatoes, and disclose if there were gm-specific modifications in potato rhizodeposition, and (2) to compare these results with conventional bulk parameters of microbial activity in soil. we have raised potatoes from a non-transgenic line (solanum tuberosum l. cv. désirée) and three gm lines, which expressed a gene f ... | 2006 | 16978573 |
| genomic-independent action of thyroid hormones on ntpdase activities in sertoli cell cultures from congenital hypothyroid rats. | the sertoli cells play an essential role in the maintenance and control of spermatogenesis. the ecto-nucleoside triphosphate diphosphohydrolase (e-ntpdase) and 5'-nucleotidase activities can modulate the extracellular adenine nucleotide levels, controlling nucleotide-mediated signaling events in sertoli cells. since thyroid hormones (th) and adenine nucleotides and nucleosides play important modulatory roles in sertoli cell proliferation and differentiation, the aim of our study was to investiga ... | 2006 | 16978660 |
| phase i trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer. | to establish the feasibility and efficacy of chemotherapy with capecitabine, weekly irinotecan, cetuximab, and pelvic radiotherapy for patients with locally advanced rectal cancer. | 2006 | 16979839 |
| population-based analyses of lymph node metastases in colorectal cancer. | the potential presence of lymph node metastases in patients with colorectal cancer (crc) limits the application of minimally invasive techniques of resection. we used data from the national cancer institute's surveillance, epidemiology, and end results registry to better understand the underlying risk of lymph node metastases and factors that influence this risk in a population-based fashion. | 2006 | 16979956 |
| unfavorable pathological characteristics in familial colorectal cancer with low-level microsatellite instability. | a high degree of microsatellite instability (msi) in colorectal cancer (crc) is a hallmark of hereditary non-polyposis colorectal cancer (hnpcc), caused by germline defects in the mismatch repair (mmr) genes. a low degree of instability (less than 30% of the microsatellites) is seen in a subset of tumors. to clarify the significance of this low degree of msi phenotype, we studied the differences between patients with colorectal tumors with high-level, low-level and no msi. colorectal tumors with ... | 2006 | 16980941 |
| prolactin, cortisol secretion and thyroid function in patients with stroke of mild severity. | different attempts were made to identify the variables that may be involved in the clinical course of cerebrovascular ischemia. in the case of stroke with mild severity (sms), the clinical significance of neuroendocrine changes as well as of post-stroke depression (psd) remains unknown. we therefore evaluated the presence of neuroendocrine changes in the acute and post-acute phase of sms, and their potential role during convalescence. serum cortisol, t4, t3, ft4, ft3, tsh and prl levels were mea ... | 2006 | 16981141 |
| importance of individual side chains for the stability of a protein fold: computational alanine scanning of the insulin monomer. | a new computational approach is proposed to probe the importance of residue side chains for the stability of a protein fold. computational mutations to estimate protein stability (cmeps) is based on the notion that the binding free energy corresponding to the complexation of a given side chain, considered as a "pseudo-ligand" of the wild type protein, reflects the importance of this side chain to the thermodynamic stability of the protein. the contribution of a particular side chain to the foldi ... | 2006 | 16981237 |
| bacteriophage t4 capsid: a unique platform for efficient surface assembly of macromolecular complexes. | we report the first description of a macromolecular complex display system using bacteriophage t4. decorated with two dispensable outer capsid proteins, hoc (155 copies) and soc (810 copies), the 120 nm x 86 nm t4 capsid particle offers a unique binding site-rich platform for surface assembly of hetero-oligomeric complexes. to display the 710 kda anthrax toxin complex, two bipartite functional fusion proteins, lf-hoc and lfn-soc, were constructed. using a defined in vitro binding system, sequent ... | 2006 | 16982068 |
| effects of perinatal exposure to low doses of cadmium or methylmercury on thyroid hormone metabolism in metallothionein-deficient mouse neonates. | perinatal exposure to cadmium (cd) or methylmercury (mehg) results in impaired neurodevelopment. thyroid hormone is essential for normal brain development. however, the issue whether cd or mehg, especially at low doses, interrupts thyroid hormone action remains to be investigated. in the present study, effects of perinatal exposure to low levels of cd or mehg on thyroid hormone metabolism were examined using metallothionein i and ii (mt-i/ii) null or wild-type neonatal mice. dams were exposed to ... | 2006 | 16982123 |
| prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community-based cross-sectional survey. | population-based screening has been advocated for subclinical thyroid dysfunction in the elderly because the disorder is perceived to be common, and health benefits may be accrued by detection and treatment. | 2006 | 17003083 |
| circulating hormones and hypothalamic energy balance: regulatory gene expression in the lou/c and wistar rats. | to ascertain the mechanisms underlying low caloric intake and low body weight in the lou/c rat, the circulating hormone levels and gene expression of hypothalamic peptides and receptors important in energy balance and the induction of suppressor of cytokine signalling 3 (socs3) gene expression in response to leptin challenge were compared with wistar rats. plasma leptin levels were lower in the lou/c rat, as were levels of rat corticosterone, tsh and t4 but not t3. ghrelin levels were higher in ... | 2006 | 17003258 |
| neglected squamous cell carcinoma of the frontal area: a clinical report. | neglected skin carcinomas are not very often in our days. it is known that skin is the most common site of malignancy squamous cell carcinoma (scc) is the second most common malignancy of the skin. we report a combined surgical treatment in an unusual case of a squamous cell carcinoma (t4 n0 m0) localized on scalp, presented primarily as a frontal ulcerative bloody mass, with no palpable lymph nodes and a whole body negative computed tomography. three months after the first surgical procedure, t ... | 2006 | 17003637 |
| subtotal laryngectomy with tracheohyoidopexy: a possible alternative to total laryngectomy. | the objective of this study was to describe a new subtotal laryngectomy technique that foresees two variations: 1) tracheohyoidopexy (thip + a or a-a)-subtotal removal of the larynx maintaining one or two cricoarytenoid units and subsequent tracheohyoidopexy; and 2) tracheohyoidoepiglottopexy (thiep + a or a-a)-resection guarantees preservation of the suprahyoid epiglottis maintaining one or two cricoarytenoid units and further suspension of the tracheal stump at the epiglottis and hyoid bone. | 2006 | 17003702 |
| biochemical analysis of the substrate specificity and sequence preference of endonuclease iv from bacteriophage t4, a dc-specific endonuclease implicated in restriction of dc-substituted t4 dna synthesis. | endonuclease iv encoded by denb of bacteriophage t4 is implicated in restriction of deoxycytidine (dc)-containing dna in the host escherichia coli. the enzyme was synthesized with the use of a wheat germ cell-free protein synthesis system, given a lethal effect of its expression in e.coli cells, and was purified to homogeneity. the purified enzyme showed high activity with single-stranded (ss) dna and denatured dc-substituted t4 genomic double-stranded (ds) dna but exhibited no activity with dsd ... | 2006 | 16971463 |
| chemotherapy with preoperative radiotherapy in rectal cancer. | preoperative radiotherapy is recommended for selected patients with rectal cancer. we evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer. | 2006 | 16971718 |
| serotonin potentiates sympathetic responses evoked by spinal nmda. | in urethane-chloralose anaesthetized, neuromuscularly blocked, ventilated rats, we examined the effects on sympathetic outflow to brown adipose tissue (bat) of separate and simultaneous spinal microinjections of nmda and serotonin. microinjection of nmda (12 pmol) into the right t4 spinal intermediolateral nucleus (iml) immediately increased ipsilateral brown adipose tissue (bat) sympathetic nerve activity (sna; peak: +546% of control), bat thermogenesis (+0.8 degrees c) and heart rate (+53 beat ... | 2006 | 16973701 |
| cardiovascular and temperature changes in spinal cord injured rats at rest and during autonomic dysreflexia. | in patients with high spinal cord injuries autonomic dysfunction can be dangerous, leading to medical complications such as postural hypotension, autonomic dysreflexia and temperature disturbance. while animal models have been developed to study autonomic dysreflexia, associated temperature changes have not been documented. our aim here was to use radiotelemetry and infrared thermography in rodents to record the development of cardiovascular and skin temperature changes following complete t4 tra ... | 2006 | 16973703 |
| chemo-radiation in advanced nasopharyngeal carcinoma, disease free after 6 years--a case report. | this is a case report of a patient with advanced nasopharyngeal carcinoma, (t4 n2 mo) who had chemo-radiation with cisplatin based chemotherapy and total midplane dose of 60 gray external beam radiation. six years after treatment patient has remained disease free and the primary site histologically confirmed disease free with no clinical evidence of regional or distance metastases | 2006 | 16986298 |
| agreement between picco pulse-contour analysis, pulmonal artery thermodilution and transthoracic thermodilution during off-pump coronary artery by-pass surgery. | haemodynamic instability during off-pump coronary artery bypass surgery (opcab) may appear rapidly, and continuous monitoring of the cardiac index (ci) during the procedure is advisable. with the picco monitor, ci can be measured continuously and almost real time with pulse-contour analysis and intermittently with transthoracic thermodilution. the agreement between pulmonal artery thermodilution ci (tpa), transthoracic thermodilution ci (tpc) and pulse-contour ci (pcci) during opcab surgery has ... | 2006 | 16987335 |
| the dna translocating atpase of bacteriophage t4 packaging motor. | in double-stranded dna bacteriophages the viral dna is translocated into an empty prohead shell by a powerful atp-driven motor assembled at the unique portal vertex. terminases consisting of two to three packaging-related atpase sites are central to the packaging mechanism. but the nature of the key translocating atpase, stoichiometry of packaging motor, and basic mechanism of dna encapsidation are poorly understood. a defined phage t4 packaging system consisting of only two components, proheads ... | 2006 | 16987527 |
| sunflower (helianthus annuus l.). | sunflower (helianthus annuus l.) is considered one of the recalcitrant species in terms of transformation and regeneration. a routine transformation system of this crop requires competent cell cultures for efficient plant regeneration as well as an effective method for gene delivery. a transformation system was developed by an agrobacterium tumefaciens-mediated method using split mature embryonic axis explants from the ha89 genotype. mean transformation efficiency obtained (measured as pcr+ plan ... | 2006 | 16988353 |
| [the histo-clinical analysis of 95 malignant neoplasms of parotid gland]. | malignant tumors constituted 25% of all gland tumors, the most frequently in parotid gland. | 2006 | 16989441 |