Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| dipolar coupling between nitroxide spin labels: the development and application of a tether-in-a-cone model. | a tether-in-a-cone model is developed for the simulation of electron paramagnetic resonance spectra of dipolar coupled nitroxide spin labels attached to tethers statically disordered within cones of variable halfwidth. in this model, the nitroxides adopt a range of interprobe distances and orientations. the aim is to develop tools for determining both the distance distribution and the relative orientation of the labels from experimental spectra. simulations demonstrate the sensitivity of electro ... | 2006 | 16214868 |
| preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma. | to study the safety and efficacy of dose escalation in tumor for locally advanced nasopharyngeal carcinoma (npc). | 2006 | 16213105 |
| oxygen-modifying treatment with arcon reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck. | to evaluate the prognostic significance of hemoglobin (hb) levels measured before and during treatment with accelerated radiotherapy with carbogen and nicotinamide (arcon). | 2006 | 16213107 |
| effects of fentin hydroxide on reproduction of the japanese quail (coturnix coturnix japonica). | in a one-generation reproductive study, the fungicidal compound triphenyltin hydroxide (fentin) was administered to adult japanese quail for 6 weeks at dietary levels of 3 and 30 ppm. reproduction was significantly impaired in the high-dose group. the principal adverse finding was a marked increase in embryonic mortality, resulting in a lower hatch rate. furthermore, a reduction in egg production was observed with ongoing duration of treatment. most of the other reproduction-related parameters w ... | 2006 | 16162336 |
| thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy. | migration and superoxide anion (o2-) generation were studied in polymorphonuclear leukocytes (pmns) from 14 athyreotic patients, previously treated by total thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma, and from age- and sex-matched euthyroid healthy controls. patients were studied twice: in hypothyroidism (visit 1) and after tsh-suppressive l-t4 replacement therapy (visit 2). random migration and n-formyl-met-leu-phe (fmlp) 0.1-microm induced chemotaxis were simila ... | 2006 | 16154598 |
| a genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the faroe islands. | the involvement of genetic factors in the etiology of autism has been clearly established. we undertook a genome-wide search for regions containing susceptibility genes for autism in 12 subjects with childhood autism and related pervasive developmental disorders (pdds) and 44 controls from the relatively isolated population of the faroe islands. in total, 601 microsatellite markers distributed throughout the human genome with an average distance of 5.80 cm were genotyped, including 502 markers i ... | 2006 | 16205737 |
| transcription and rna processing during expression of genes preceding dna ligase gene 30 in t4-related bacteriophages. | early gene expression in bacteriophage t4 is controlled primarily by the unique early promoters, while t4-encoded regb endoribonuclease promotes degradation of many early messages contributing to the rapid shift of gene expression from the early to middle stages. the regulatory region for the genes clustered upstream of dna ligase gene 30 of t4 was known to carry two strong early promoters and two putative regb sites. here, we present the comparative analysis of the regulatory events in this reg ... | 2006 | 16225899 |
| targeted disruption of the type 1 selenodeiodinase gene (dio1) results in marked changes in thyroid hormone economy in mice. | the type 1 deiodinase (d1) is thought to be an important source of t3 in the euthyroid state. to explore the role of the d1 in thyroid hormone economy, a d1-deficient mouse (d1ko) was made by targeted disruption of the dio1 gene. the general health and reproductive capacity of the d1ko mouse were seemingly unimpaired. in serum, levels of t4 and rt3 were elevated, whereas those of tsh and t3 were unchanged, as were several indices of peripheral thyroid status. it thus appears that the d1 is not e ... | 2006 | 16223863 |
| thyrotropin suppression by metformin. | drug-drug interactions are common but often are discovered only long after initial drug release. metformin has been available in the united states for 9 yr and elsewhere for many years, but as of yet there are no reports that the drug modifies thyroid hormone economy. | 2006 | 16219720 |
| t-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of poly halogenated aromatic hydrocarbons (phahs). | the present study investigates chemical thyroid hormone disruption at the level of thyroid hormone receptor (tr) functioning. to this end the (ant)agonistic action of a series of xenobiotics was tested in the newly developed t-screen. this assay makes use of a gh3 rat pituitary cell line, that specifically proliferates when exposed to 3,3',5-triiodo-l-thyronine (t3). the growth stimulatory effect is mediated via t3-receptors. (ant)agonistic and potentiating action of compounds was studied in abs ... | 2006 | 16219445 |
| the human cd94 gene encodes multiple, expressible transcripts including a new partner of nkg2a/b. | cd94/nkg2a is an inhibitory receptor expressed by natural killer (nk) cells and a subset of cd8+ t cells. ligation of cd94/nkg2a by its ligand hla-e results in tyrosine phosphorylation of the nkg2a immunoreceptor tyrosine-based inhibitory motifs, and recruitment and activation of the sh2 domain-bearing tyrosine phosphatase-1, which in turn suppresses activation signals. the nkg2a gene encodes two isoforms, nkg2a and nkg2b, with the latter lacking the stem region. we identified three new alternat ... | 2006 | 16237464 |
| increased pulse wave velocity in subclinical hypothyroidism. | subclinical hypothyroidism affects 5-15% of the general population and is associated with increased morbidity from cardiovascular disease. brachial-ankle pulse wave velocity (bapwv) is a parameter of arterial stiffening and a good independent predictor for the presence of coronary artery disease. this study was performed to assess whether subclinical hypothyroidism might cause enhanced bapwv. | 2006 | 16234303 |
| excimer laser trabeculotomy: a new, minimally invasive procedure for patients with glaucoma. | excimer laser trabeculotomy (elt) ab interno is a new surgical technique to reduce intraocular pressure (iop) in patients with glaucoma or ocular hypertension. our purpose was to examine iop reduction and the use of antiglaucoma drugs (agd) in patients treated with elt and to evaluate the safety of this laser treatment. | 2006 | 16235060 |
| disorders of eating behavior: correlation between hypothalamo-pituitary-thyroid function and psychopathological aspects. | altered pituitary-thyroid (pt) function (tsh, ft4, ft3 plasma levels) was correlated with symptoms of eating disorders (ed) in 137 patients (65 anr, 12 anp, 19 anbp, 26 bn, 8 ednos-an, 7 ednos-bn) and 30 controls. pt hormone concentrations were assessed by immunofluorimetry and psychopathology by edi-2 and hscl-90. values of tsh were decreased in anp, bn, ednos-an, of t4 in anr, anp, an-bp, of t3 in anr, anp, anbp, bn, ednos-an, ednos-bn. tsh values correlated negatively with ineffectiveness in ... | 2006 | 16112494 |
| functional characterization of delta9 and omega9 desaturase genes in mortierella alpina 1s-4 and its derivative mutants. | cloning and characterization of the delta9 desaturase (delta9i) gene of a fungus, mortierella alpina 1s-4, was previously reported. in this study, two genes encoding delta9 desaturase homologs were isolated from this fungus. one is a delta9 desaturase (delta9ii) that exhibits 86% amino acid sequence similarity to delta9i. functional analysis involving expression of the encoding gene in aspergillus oryzae revealed that delta9ii exhibits delta9 desaturase activity, 18:0 being converted to 18:1delt ... | 2006 | 16133334 |
| chronic pancreatitis patients show hyperalgesia of central origin: a pilot study. | the pain of chronic pancreatitis remains challenging to manage, with treatment all too often being unsuccessful. a main reason for this is lacking understanding of underlying mechanisms of chronic pain in these patients. | 2006 | 16087373 |
| the european smoking prevention framework approach (esfa): effects after 24 and 30 months. | the european smoking prevention framework approach (esfa) study in six countries tested the effects of a comprehensive smoking prevention approach after 24 (t3; n = 10,751) and 30 months (t4; n = 9,282). the programme targeted four levels, i.e. adolescents in schools, school policies, parents and the community. in portugal, 12.4% of the t1 non-smokers in the control group had started smoking at t4 compared to 7.9% of the experimental group. smoking onset in the experimental group was thus 36% lo ... | 2006 | 16087692 |
| long-day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the saanen goat, a short-day breeder: implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axis. | in most animals that live in temperate regions, reproduction is under photoperiodic control. in long-day breeders such as japanese quail and djungarian hamsters, type 2 deiodinase (dio2) plays an important role in the mediobasal hypothalamus, catalyzing the conversion of prohormone t4 to bioactive t3 to regulate the photoperiodic response of the gonads. however, the molecular basis for seasonal reproduction in short-day breeders remains unclear. because thyroid hormones are also known to be invo ... | 2006 | 16195409 |
| gene profiling involved in immature cd4+ t lymphocyte responsible for systemic lupus erythematosus. | we attempted to characterize the genes expression of cd4+ t lymphocytes for the pathogenesis of systemic lupus erythematosus (sle). genomewide gene expression profiles of cd4+ t cells, which were isolated from the disease severe activity (t4-1s) and nonactivity (t4-2s) with an sle patient by using long serial analysis of gene expression (longsage). we picked out 289 genes matching to unigene cluster with different expression more than four copies between t4-1s and t4-2s libraries and analyzed th ... | 2006 | 16143398 |
| is dissection of level iv absolutely necessary in elective lateral neck dissection for clinically n0 laryngeal carcinoma? | a prospective study of 73 previous untreated consecutive patients with clinically n0 laryngeal squamous cell carcinoma (scc) from january 1997 to october 2002 was undertaken to determine whether level iv lymph nodes can be saved in elective lateral neck dissection (lnd) performed as a treatment for the n0 neck. the incidence of pathological metastases to level iv lymph nodes was evaluated, as were the incidence of regional recurrence after elective lnd, and postoperative complications such as ch ... | 2006 | 16143563 |
| enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection. | in patients with high thoracic spinal lesions that remove most of the central drive to splanchnic preganglionic neurons, visceral or nociceptive stimuli below the lesion can provoke large increases in blood pressure (autonomic dysreflexia). we have examined the effects of t4 spinal transection on isometric contractions of mesenteric arteries isolated from spinalized rats. nerve-evoked contractions involved synergistic roles for norepinephrine and atp. at 7 wk after spinal transection, responses ... | 2006 | 16143650 |
| regulation of iodothyronine deiodinase and roles of thyroid hormones in human coronary artery smooth muscle cells. | thyroid hormones have been reported to have significant effects on the peripheral vascular system, including relaxation of vascular smooth muscle cells and prevention of atherosclerosis. to exert its biological activity, thyroxine (t4) needs to be converted to 3,5,3'-triiodothyronine (t3) by type 1 and type 2 iodothyronine deiodinases. we have previously identified type 2 iodothyronine deiodinase (d2) expression in cultured human coronary artery smooth muscle cells (hcasmcs). in the present stud ... | 2006 | 16140305 |
| methylmercury inhibits type ii 5'-deiodinase activity in nb41a3 neuroblastoma cells. | methylmercury (mehg) is a well-known neurotoxicant and prenatal exposure to mehg results in severe brain damage. since mehg has a high affinity for thiol groups, we sought to determine whether mehg inhibited type ii iodothyronine deiodinase (d2) activity, by which prohormone thyroxine (t4) is converted to active thyroid hormone, 3,5,3'-triiodothyronine (t3) in the brain, using nb41a3 mouse neuroblastoma cells. in mehg-treated cells, d2 activity was inhibited in a dose- and time-dependent manner; ... | 2006 | 16140479 |
| adiponectin, leptin and thyroid hormones in patients with chronic renal failure and on renal replacement therapy: are they related? | renal function affects thyroid function and adipocytokines in many ways. we aimed to assess the adipocytokines adiponectin and leptin in relation to thyroid function in patients with chronic renal failure treated conservatively, in haemodialysed patients and in kidney allograft recipients. | 2006 | 16141459 |
| development of metamorphosis assay using silurana tropicalis for the detection of thyroid system-disrupting chemicals. | the west african clawed frog (silurana tropicalis), which resembles the south african clawed frog (xenopus laevis), but is somewhat smaller, has a diploid genome and a shorter generation time. therefore, s. tropicalis has the potential for use as a new model in ecotoxicology. we demonstrated a s. tropicalis metamorphosis assay based on xenopus metamorphosis assay (xema) using 1 microg/l thyroxine (t4) and 75 mg/l propylthiouracil (ptu). tadpoles at developmental stages 48-50 were exposed to chem ... | 2006 | 16139362 |
| pcdds, pcdfs, and coplanar pcbs in wild terrestrial mammals from japan: congener specific accumulation and hepatic sequestration. | the present study determined the contamination levels and congener-specific accumulation features of dioxins and related compounds (drcs) in wild terrestrial mammals such as large japanese field mice (ljfm), lesser japanese moles (ljms), and raccoon dogs (rds) collected from kanto region in japan during 2001. the toxic equivalent quantity (teq) levels in the carcasses or adipose tissues were in the order of rds > or = ljms > ljfm. comparison of drc congener profiles in the three species and prin ... | 2006 | 16159690 |
| extract of lycopus europaeus l. reduces cardiac signs of hyperthyroidism in rats. | extracts from the plant lycopus europaeus l. are traditionally used in mild forms of hyperthyroidism. high doses caused a reduction of tsh or thyroid hormone levels in animal experiments, whereas in hyperthyroid patients treated with low doses of lycopus an improvement of cardiac symptoms was reported without major changes in tsh or thyroid hormone concentrations. lycopus extract was tested in thyroxine treated hyperthyroid rats (0.7 mg/kg bw i.p.). co-treatment with an hydroethanolic extract fr ... | 2006 | 16150466 |
| thyroid epithelial cell hyperplasia in ifn-gamma deficient nod.h-2h4 mice. | the role of inflammatory cells in thyroid epithelial cell (thyrocyte) hyperplasia is unknown. here, we demonstrate that thyrocyte hyperplasia in ifn-gamma-/- nod.h-2h4 mice has an autoimmune basis. after chronic exposure to increased dietary iodine, 60% of ifn-gamma-/- mice had severe thyrocyte hyperplasia with minimal or moderate lymphocyte infiltration, and thyroid dysfunction with reduced serum t4. all mice produced anti-thyroglobulin autoantibody. some wild-type nod.h-2h4 mice had isolated a ... | 2006 | 16150647 |
| thyroid hormone deiodinases revisited: insights from lungfish: a review. | in vertebrates, hormones released from the thyroid gland travel in the circulation to target tissues where they may be processed by deiodinating enzymes into more active or inactive iodothyronines. in mammals, there are three deiodinating enzymes described. type1 (d1), which primarily occurs in the liver, converts reverse t3 into t2 for clearance. it also converts t4 into t3. this production of t3 is believed to contribute to the bulk of circulating t3 in mammals. the type2 (d2) enzyme may be fo ... | 2006 | 16151818 |
| [clinical and immunobiochemical study of efficacy and stress-protective properties of thyroliberin at the acute stage of carotid ischemic stroke]. | stress-promoting system is known to be involved in course and outcome of acute stage of ischemic stroke. an important predictor of an unfavorable course of stroke is so-called "low t3-syndrome". therapy with drugs increasing t3 level on the background of reduced reaction of oxidative stress is one of a perspective direction of neuroprotection. the study aimed at investigating thyroliberin influence on a clinical course and an outcome of ischemic atherothrombotic stroke as well as on thyroid horm ... | 2006 | 18196636 |
| thyroid dysfunction in down syndrome. | down syndrome is associated with various forms of thyroid dysfunction, hypothyroidism being the most common. the additive effects of both co-morbid conditions lead to further amplification of the clinical problems in these children with down syndrome. | 2006 | 18603895 |
| a study of therapeutic effect of the growth of children with hypothyroidism. | this study was done to see the therapeutic effect of the growth of children who was diagnosed as hypothyroidism. | 2006 | 18603928 |
| relationship between anti-thyroid peroxidase antibody and thyroid function test. | anti-thyroid peroxidase antibody (anti-tpo antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. | 2006 | 18698125 |
| comparative studies between portuguese and japanese isolates of the pinewood nematode, bursaphelenchus xylophilus. | comparative studies between portuguese (t and hf) and japanese (s10, t4, c14-5 and okd-1) isolates of the pinewood nematode bursaphelenchus xylophilus have been made in order to provide information to better understand the possible origin of the portuguese isolates, recently introduced in the european union. the main comparative aspects investigated were pathogenicity (seedling mortality ratio), sexual compatibility, and dna sequences of the rdna region. four-year-old japanese black pine (pinus ... | 2006 | 19259459 |
| hyperthyroidism induces glucose intolerance by lowering both insulin secretion and peripheral insulin sensitivity. | the objectives of this study were to examine the effects of hyperthyroidism on glucose tolerance, insulin secretion, and insulin sensitivity. | 2006 | 17718254 |
| the incidence and risk factors of hypotension and bradycardia associated with spinal anesthesia. | hypotension and bradycardia after conduction of spinal anesthesia are common and may lead to intraoperative cardiac arrest or death. the present study was carried out to investigate the incidence and risk factors of hypotension and/or bradycardia in the patients receiving spinal anesthesia. | 2006 | 17718270 |
| [the value of cervical lymph node ultrasound examination in patients suffering from laryngeal cancer]. | 51 patients with laryngeal cancer were surgically treated on the ent departament of the st lukas district hospital in tarnow between the years 1997-2000. the local advancement was stated as t3 and t4 according to the tnm system. the high grade of tumour differentiation (g1) was established in 13 patients (25.5%), mediam (g2) in 22 (43.1%), and low grade (g3) in 16 patients (31.4%). according to usg examination lymph nodes were estimated as no in 20 patients (39.2%), as n1 in 21 (41.2%), and as n ... | 2006 | 17806194 |
| influence of autonomic impairment on blood-pressure and heart-rate scaling structures. | self similarity is a promising tool for quantifying alterations in cardiovascular dynamics, although the effect of the autonomic control on the scaling structure of cardiovascular signals is still unknown. to address this issue, we studied spinal-cord injured subjects as a model of progressively impaired vascular control. we considered 24 able-bodied subjects (ab) and 23 paraplegics with lesion at different levels: between t12 and l4 (n=7); t5 and t11 (n=9); and c6 and t4 (n=7). we recorded bloo ... | 2006 | 17946047 |
| dosimetric consequences of breath-hold respiration in conformal radiotherapy of esophageal cancer. | the objective of this paper is to study the dosimetric impact of respiratory gated radiotherapy in locally advanced esophageal carcinomaand to define the optimal respiratory phase for this treatment. the study included 8 consecutive patients with squamous-cell carcinoma (scc) or histologically proved adenocarcinoma, for both at least t3-t4 nx or tx n1 m0 stage. informed consent was obtained before beginning the study. three spiral scans were performed in breath-hold respiration: one acquisition ... | 2006 | 17643895 |
| histopathologic outcomes of robotic radical prostatectomy. | robotically assisted laparoscopic radical prostatectomy is a minimally invasive alternative for the treatment of prostate cancer. we report the histopathologic and short-term psa outcomes of 500 robotic radical prostatectomies. five hundred patients underwent robotic radical prostatectomy. the procedure was performed via a six trocar transperitoneal technique. prostatectomy specimens were analyzed for tnm stage, gleason's grade, tumor location, volume, specimen weight, seminal vesicle involvemen ... | 2006 | 17619732 |
| [beckwith-wiedemann syndrom: a case report in dakar]. | beckwith-wiedemann syndrome is a congenital syndrome with variable phenotypic expression. it is less commonly described in africa. we report a case in dakar universitary hospital center. | 2006 | 17632986 |
| effect of supplementation of dietary protected lipids on intake and nutrient utilization in deccani lambs. | four complete isonitrogenous (crude protein 13%) rations with 0 (t1), 5 (t2), 10 (t3) and 15 (t4) per cent calcium soap from red palm oil (protected fat) were formulated and evaluated using four deccani lambs (19.32 +/- 0.82 kg) in a completely randomized design at the end of a growth trial. the average daily dry matter intake (% body weight or g/kg w0.75 per day) in lambs fed ration t4 was significantly (p < 0.05) lower than in those fed rations t1, t2, and t3. there was no significant differen ... | 2006 | 17682600 |
| effects of orlistat therapy on plasma concentrations of oxygenated and hydrocarbon carotenoids. | orlistat is a lipase inhibitor that is applied for treating obesity. lipases are required for digestion and absorption of dietary lipids and fat-soluble vitamins and carotenoids. the aim of this study was to compare the effects of orlistat therapy on plasma concentrations of oxygenated (beta-cryptoxanthin, lutein/zeaxanthin) and hydrocarbon (alpha-, beta-carotene, lycopene) carotenoids. six patients with a body mass index (bmi) > or = 30 kg/m2 received 360 mg/d orlistat over 4.5 mon. plasma caro ... | 2006 | 17707976 |
| thyroid hormone responses to endurance exercise. | limited information exists about changes in circulating thyroid hormone concentrations during prolonged endurance exercise in horses. | 2006 | 17402388 |
| [establishment of an animal model for thyroid associated ophthalmopathy by treatment of mice with human thyrotropin receptors-activated splenocytes]. | objective: to establish an animal model for thyroid-associated ophthalmopathy (tao) by treatment of homoimmune balb/c mice with human thyrotropin receptors ( htshr )-activated splenocytes. methods twenty three balb/c mice were randomly divided into group a and b, which were immune with recombinant plasmid pcdna3. 1/htshr or blank plasmid pcdna3. 1 for 3 times at 3-week intervals, respectively. mice in these two groups were sacrificed 18 weeks after immunization and the splenocytes were isolated. ... | 2006 | 17415963 |
| [impact of extracapsular lymph node spread in the ipsilateral neck on contralateral neck metastasis and prognosis of laryngeal cancer]. | to evaluate the impact of extracapsular lymph node spread (ecs) in the ipsilateral neck on the contralateral neck metastasis and prognosis of laryngeal cancer. | 2006 | 17416015 |
| hypermutagenesis in muta cells is mediated by mistranslational corruption of polymerase, and is accompanied by replication fork collapse. | elevated mistranslation induces a mutator response termed translational stress-induced mutagenesis (tsm) that is mediated by an unidentified modification of dna polymerase iii. here we address two questions: (i) does tsm result from direct polymerase corruption, or from an indirect pathway triggered by increased protein turnover? (ii) why are homologous recombination functions required for the expression of tsm under certain conditions, but not others? we show that replication of bacteriophage t ... | 2006 | 17427291 |
| [malignant neoplasm of nose and paranasal sinuses in lower silesia in years 1992-2001]. | malignant neoplasms of the nose and paranasal sinuses occur rarely but due to late diagnosis and poor treatment effects still remain a serious problem. the aim of the study was the analysis of all nose and paranasal sinus neoplasms treated at lower silesia in the years 1992-2001. | 2006 | 17427494 |
| locally advanced cheek carcinoma; radical surgery and reconstruction of though and through defects. | squamous cell carcinoma of the cheek is a locoregionally aggressive tumor. radical resection may be curative in cases of large tumor without distant metastases. we reviewed forty eight consecutive cases of sq.c.c. of the oral cavity to evaluate the feasibility and efficacy of the reconstructive method. | 2006 | 17496939 |
| [correlation of cervical lymphatic metastasis to prognosis of t3-t4 glottic cancer]. | the cervical lymphatic metastasis rate of glottic cancer is low, and has seldom been reported. this study was to explore the factors related to cervical lymphatic metastasis of t3-t4 glottic cancer, and analyze its correlation to prognosis. | 2006 | 17059774 |
| [continuous epidural anesthesia in patients after surgical treatment for scoliosis]. | analgesia after major spinal orthopedic surgery is a problem to be solved. the authors' original procedure for using continuous epidural anesthesia following scoliosis surgery is an effective mode of upgrading the quality of analgesia within the first 24 hours and diminishing postoperative stress. a visual analogue scale was used to evaluate the efficiency of the procedure. the levels of stress hormones (cortisol, t3, and t4) were measured. | 2006 | 17061592 |
| satellite pulmonary nodule in the same lobe (t4n0) should not be staged as iiib non-small cell lung cancer. | treatment of non-small cell lung cancer depends on stage. patients with t4 lesions represent a heterogeneous group. | 2006 | 17062253 |
| transient recycling of resected bone to facilitate mandibular reconstruction--a technical note. | mandibular reconstruction requires considerable sculptural skills. the intriguingly complex configuration of the structure is difficult to reproduce. it is thus imperative for surgeons to seek a technique that improves the precision of the reconstruction. | 2006 | 17055734 |
| [survival analysis for localized renal cell carcinoma. prognostic value of 1997 tnm classification]. | the 5th edition of tnm classification for renal cell carcinoma changed the cut-off point of the tumor size for localized tumors, achieving a better distribution of patients with similar survival. nevertheless, because of the variable evolution of renal cell carcinoma, the prognostic significance of tumor size is questioned as a staging criterion in organ-confined renal cell carcinoma. we analyse renal cell carcinoma specific survival and the prognostic significance of tumor size in i and ii stag ... | 2006 | 17058609 |
| number of lymph nodes examined and its impact on colorectal cancer staging. | the status of lymph nodes is the most important prognosticator in colorectal cancer patients. patients with lymph node involvement have a lower survival rate and are candidates for adjuvant therapy. the purpose of our study was to determine the number of lymph nodes that needs to be examined to accurately detect nodal metastasis. we conducted a retrospective study of 151 patients who underwent colorectal cancer operation at harbor-ucla medical center. data from the operative report and pathology ... | 2006 | 17058731 |
| [brain protective effects of ginkgo biloba leaf extract (ginaton) in patients undergoing hypothermic cardiopulmonary bypass]. | to investigate the brain protective effects of ginkgo biloba leaf extract (ginaton) in patients who underwent hypothermic cardiopulmonary bypass (cpb). | 2006 | 17058828 |
| neuroarthropathy of the wrist in paraplegia: a case report. | neuroarthropathy, also known as charcot joint, is most commonly seen in the spine and other weight-bearing joints in individuals with spinal cord injury (sci). it is rarely seen in the joints of the upper extremities because the pathophysiology of the neuroarthropathy is thought to be significant repetitive trauma such as with weight bearing in an insensate joint. | 2006 | 17044396 |
| effect of selenium supplementation on activity and mrna expression of type 1 deiodinase in mice with excessive iodine intake. | to investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mrna expression of type 1 deiodinase (d1) in mice with excessive iodine (ei) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. | 2006 | 17044649 |
| endobronchial intratumoral chemotherapy (eitc) followed by surgery in early non-small cell lung cancer with polypoid growth causing erroneous impression of advanced disease. | seventeen patients with (m0) non-small cell lung cancer (nsclc) without distant metastasis were treated by preoperative endobronchial intratumoral chemotherapy (eitc) followed by surgery. preoperative intratumoral chemotherapy was performed for the purpose of either reducing the extent of resection or increasing operability. clinically, in the preliminary diagnostic bronchoscopic examination, the tumor was located in the main stem bronchus closer than 2 cm to the carina [t3] in 12 patients, or a ... | 2006 | 17045361 |
| predictive poor prognostic factors in colonic carcinoma. | five-year survival in rectal cancer has been steadily improving since the introduction of neoadjuvant chemoradiation and total mesorectal excision surgery. in contrast, 5-year survival rates and management of colonic carcinoma remain relatively unchanged. this study aims to identify poor prognostic factors in colonic cancer patients that could potentially be predicted pre-operatively to identify a subset of patients amenable to neoadjuvant treatment strategies. | 2006 | 17045800 |
| mri and endoscopic ultrasonography in the staging of gastric cancer. | to determine the diagnostic precision of endoscopic ultrasounds (eus) and magnetic resonance imaging (mri) in the preoperative staging of gastric cancer. | 2006 | 17048994 |
| a segmental radiological study of the spine and rib--cage in children with progressive infantile idiopathic scoliosis. | the role of rib cage in the development of progressive infantile idiopathic scoliosis (iis) has not been studied previously. no report was found for rib growth in children with iis. these findings caused us to undertake a segmental radiological study of the spine and rib-cage in children with progressive iis. the aim of the present study is to present a new method for assessing the thoracic shape in scoliotics and in control subjects and to compare the findings between the two groups. | 2006 | 17049098 |
| accuracy of endoscopic ultrasound staging of gastric cancer in routine clinical practice in singapore. | endoscopic ultrasound has emerged as the leading modality to assess the t and n stage in gastric cancer. this study aimed to assess the accuracy of tn staging by endoscopic ultrasound in routine clinical practice in singapore. | 2006 | 17054580 |
| adrenocortical response to stress and thyroid hormone status in free-living nestling white storks (ciconia ciconia) exposed to heavy metal and arsenic contamination. | endocrine parameters have proven useful in the detection of early or low-level responses to pollutants. although most of the studies on endocrine modulation have been focused on processes involving gonadal steroids, contaminants may target other parts of the endocrine system as well. in this study we examined the adrenocortical stress response and thyroid hormone status in free-living nestling white storks (ciconia ciconia) in relation to heavy metals (zinc, lead, copper, cadmium) and arsenic le ... | 2006 | 17035132 |
| [the influence of proprioceptive insoles (bourdiol) on the sagittal curvature and inclination of the trunk]. | proprioceptive insoles rely on the concept of réné-jaques bourdiol, a french neurologist. the aim is to modulate plantar surface sensibility and to influence posture and statics of patients: it is hypothesized that the effect of modified afferent sensory input through proprioceptive stimulation of terminal muscle chains will have either a relaxing or stimulating effect on the whole body, which may be realized by affecting the posture. small pads with a thickness of typically 1-3 mm are embedded ... | 2006 | 17036233 |
| [analysis of mono-side sternohyoid myo-osteal flap used in reconstruction after partial laryngectomy]. | to evaluate the reconstruction effect and to investigate applied indication of unilateral sternohyoid muscle flap with hyoid bone in laryngeal carcinoma after partial laryngectomy. | 2006 | 17037012 |
| creatinine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis. | a study was carried out on 57 patients with chronic renal failure in a hospital in kerman city, islamic republic of iran. blood samples were taken before and after haemodialysis to measure blood urea nitrogen and serum creatinine, triiodothyronine (t3) and thyroxine (t4) levels. findings revealed that before dialysis t4 in 11 cases and t3 in 29 cases were lower than the normal range, but after haemodialysis only 3 cases for t4 and 15 cases for t3 were lower than normal levels. the remaining case ... | 2006 | 17037243 |
| is intraoperative touch imprint cytology of sentinel lymph nodes in patients with breast cancer cost effective? | sentinel lymph nodes (slns) are generally evaluated postoperatively, requiring 5-7 days for assessment. slns can also be evaluated intraoperatively by using touch imprint cytology (tic), thus providing the surgeon immediate feedback and allowing for concurrent completion node dissection (cnd) for positive slns. the authors hypothesized that tic, when compared with standard postoperative sln assessment alone, would permit a cost-effective evaluation of slns in patients with clinically node-negati ... | 2006 | 17039501 |
| thyroid hormone resistance: the role of mutational analysis. | the finding of increased thyroxine (t4) and tri-iodothyronine (t3) levels in a patient with normal or increased thyroid-stimulating hormone is unexpected and presents a differential diagnosis between a thyroid-stimulating hormone-secreting pituitary adenoma, generalized resistance to thyroid hormone (rth) and laboratory artefact. without careful clinical and biochemical evaluation, errors may occur in patient diagnosis and treatment. in the case of rth, mutation of the thyroid hormone receptor b ... | 2006 | 17040361 |
| effectiveness of a glutaraldehyde formulation in decontamination of dental unit water systems. | dental-medical devices may transmit infections caused by bacteria that are usually found in water distribution systems, and which are difficult to treat and control. high bacterial contamination in the water systems of dental units is due to the presence of biofilm inside the pipes. our study evaluated the efficacy of glutaraldehyde formulated with quarternary ammonium salts (sanicide t4) examined in a previous study, employing a series of assays to confirm or otherwise the results obtained prev ... | 2006 | 17041544 |
| indication and benefit of pelvic sidewall dissection for rectal cancer. | this study was designed to clarify indication and benefit of pelvic sidewall dissection for rectal cancer. | 2006 | 17041749 |
| w4 theory for computational thermochemistry: in pursuit of confident sub-kj/mol predictions. | in an attempt to improve on our earlier w3 theory [a. d. boese et al., j. chem. phys. 120, 4129 (2004)] we consider such refinements as more accurate estimates for the contribution of connected quadruple excitations (t4), inclusion of connected quintuple excitations (t5), diagonal born-oppenheimer corrections (dboc), and improved basis set extrapolation procedures. revised experimental data for validation purposes were obtained from the latest version of the active thermochemical tables thermoch ... | 2006 | 17042580 |
| the lowest singlet-triplet excitation energy of bn: a converged coupled cluster perspective. | the notoriously small x 3pi-a 1sigma+ excitation energy of the bn diatomic has been calculated using high-order coupled cluster methods. convergence has been established in both the one-particle basis set and the coupled cluster expansion. explicit inclusion of connected quadruple excitations t4 is required for even semiquantitative agreement with the limit value, while connected quintuple excitations t5 still have an effect of about 60 cm(-1). still higher excitations only account for about 10 ... | 2006 | 17042596 |
| is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? | widespread use of automated sensitive assays for thyroid hormones and thyroid-stimulating hormone (tsh) has increased identification of mild thyroid dysfunction, especially in elderly patients. the clinical significance of this dysfunction, however, remains uncertain, and associations with cognitive impairment, depression, and anxiety are unconfirmed. | 2006 | 17043339 |
| dietary thyroid hormone improves growth and muscle protein accumulation of black-boned chickens. | 1. the objective of the study was to examine the effect of dietary thyroid hormone on performance and muscle protein accumulation of black-boned chickens. 2. a total of 720 1-d-old birds was housed in 24 pens and assigned to 4 diets containing triiodothyronine (t3) at 0, 0.1, 0.3 or 0.5 mg/kg. 3. the trial was split into starter (0 to 4 weeks) and grower (5 to 8 weeks) phases. at the beginning of the grower phase, each pen was split into two; one subgroup was fed basal diet (t3-) and the other c ... | 2006 | 17050100 |
| an approach to crystallizing proteins by synthetic symmetrization. | previous studies of symmetry preferences in protein crystals suggest that symmetric proteins, such as homodimers, might crystallize more readily on average than asymmetric, monomeric proteins. proteins that are naturally monomeric can be made homodimeric artificially by forming disulfide bonds between individual cysteine residues introduced by mutagenesis. furthermore, by creating a variety of single-cysteine mutants, a series of distinct synthetic dimers can be generated for a given protein of ... | 2006 | 17050682 |
| driving and dementia in older adults: implementation and evaluation of a continuing education project. | we aimed to develop and evaluate a multimedia workshop curriculum to educate physicians and other health professionals about (a) driving-related assessment in older adults with dementia, and (b) strategies to encourage driving retirement for impaired individuals. | 2006 | 17050760 |
| melanoma chemoprevention. | despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. the prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures. | 2006 | 17052492 |
| the stability of maxillary osteotomies fixated with biodegradable mesh in orthognathic surgery. | this study measures the stability of maxillary osteotomies fixated with 1-mm biodegradable mesh and screws. | 2006 | 17052589 |
| what influences early hypothyroidism after radioiodine treatment for graves' hyperthyroidism? | the objective of this study was to evaluate the factors influencing the occurrence of early hypothyroidism after radioiodine treatment of graves' hyperthyroidism. | 2006 | 17053385 |
| neo-adjuvant and adjuvant hormone therapy for localised and locally advanced prostate cancer. | hormone therapy for early prostate cancer has demonstrated an improvement in clinical and pathological variables, but not always an improvement in overall survival. we performed a systematic review of both adjuvant and neo-adjuvant hormone therapy combined with surgery or radiotherapy in localised or locally advanced prostate cancer. | 2006 | 17054269 |
| disseminated tumor cells in peripheral blood: a novel marker for therapy response in locally advanced rectal cancer patients undergoing preoperative chemoradiation. | this study was designed to examine whether disseminated tumor cells in peripheral blood of locally advanced rectal cancer patients undergoing preoperative chemoradiation have the potential to serve as a marker for therapy response. studies suggest that patients with advanced rectal cancer who respond to preoperative chemoradiation most likely benefit from this treatment. | 2006 | 17019657 |
| rna ligase structures reveal the basis for rna specificity and conformational changes that drive ligation forward. | t4 rna ligase 2 (rnl2) and kinetoplastid rna editing ligases exemplify a family of rna repair enzymes that seal 3'oh/5'po(4) nicks in duplex rnas via ligase adenylylation (step 1), amp transfer to the nick 5'po(4) (step 2), and attack by the nick 3'oh on the 5'-adenylylated strand to form a phosphodiester (step 3). crystal structures are reported for rnl2 at discrete steps along this pathway: the covalent rnl2-amp intermediate; rnl2 bound to an adenylylated nicked duplex, captured immediately fo ... | 2006 | 17018278 |
| diagnostic value of multidetector row ct in rectal cancer staging: comparison of multiplanar and axial images with histopathology. | although magnetic resonance (mr) imaging is widely used for rectal cancer staging, many centres in the uk perform computed tomography (ct) for staging rectal cancer at present. furthermore in a small proportion of cases contraindications to mr imaging may lead to staging using ct. the purpose of this study was to evaluate the accuracy of current generation multidetector row ct (mdct) in local staging of rectal cancer. in particular the accuracy of multiplanar (mpr) versus axial images in the sta ... | 2006 | 17018304 |
| effects of environmental temperature on thyroid hormones in the barn owl (tyto alba). | the basic patterns of thyroid hormones [thyroxine (t4) and 3,3',5-triiodothyronine (t3)] and the t4 and t3 responses induced by thyrotropin releasing hormone (trh) are reported in captive female barn owls (tyto alba) during the non-breeding period. the main findings of the study, conducted on a total of 10 owls, are as follow: (1) the thyroid gland of barn owl can be stimulated by the classical trh stimulation test. (2) t3 response was much more pronounced both under cold (around 10 degrees c) a ... | 2006 | 17020136 |
| cardio-protective role of terminalia arjuna bark extract is possibly mediated through alterations in thyroid hormones. | terminalia arjuna bark extract is believed to exhibit cardio-protective effects. in the present study we investigated the possible involvement of thyroid hormones in the amelioration of cardiac and hepatic lipid peroxidation (lpo) by a bark extract of the plant in albino rats. while l-thyroxine (l-t4) treatment increased the level of thyroid hormones, heart/body weight ratio as well as cardiac and hepatic lipid peroxidation, simultaneous administration of 21.42 and 42.84 mg/kg of the plant extra ... | 2006 | 17020158 |
| long-term functional outcome of brachytherapy for carcinoma of the mobile tongue: focus on the atrophic change of irradiated tongue. | to assess tongue atrophy and long-term functional outcome of mobile tongue cancer patients after interstitial radiotherapy. | 2006 | 17020894 |
| stability of benefits of mime therapy in sequelae of facial nerve paresis during a 1-year period. | to assess the stability of benefits of mime therapy, a modality of physiotherapy for patients with facial nerve paresis, during a period of 1 year. | 2006 | 17006356 |
| expressions of polypeptide: n-acetylgalactosaminyltransferase in leukemia cell lines during 1,25-dihydroxyvitamin d3 induced differentiation. | the effect of 1,25-dihydroxyvitamin d3 [1,25(oh)(2)d3] on two leukemia cell lines, k562 and shi-1, and its relation to the expression of different subtypes of polypeptide: n-acetylgalactosaminyltransferase (pp-galnac-t) was studied. with morphological and cell flow-cytometric method, it was found that 1,25(oh)(2)d3 induced the differentiation of both leukemia cell lines toward monocytic lineage, but not affected the cell growth and apoptosis. the expressions of different subtypes of pp-galnac-t, ... | 2006 | 17006648 |
| [the effects of amiodaron on the thyroid function]. | the use of several groups of medications may result in thyroid dysfunction including thyrotoxicosis or hypothyroidism of various degree (from subclinical to full-clinical syndrome). the mentioned disturbances may develop either on the basis of normal euthyroid gland or may overlap the previously-existing oceult changes (first of all different forms of autoimmune thyroiditis). amiodarone is a widely used anti-arrythmic drug with considerable potential to cause thyroid dysfunction because of its 3 ... | 2006 | 17007301 |
| thyroid function in pulmonary tuberculosis. | to evaluate the thyroid hormone economy in pulmonary tuberculosis (ptb). | 2006 | 17007749 |
| hormonal, auxological and clinical follow-up in children with connatal hiv infection. personal records. | hiv infection and antiretroviral drugs have relevant endocrine implications, affecting growth and pubertal development. moreover stature impairment cannot depend only on decreased hormonal secretion. | 2006 | 17008857 |
| treatment for acute lymphoblastic leukemia in children is associated with papillary carcinoma of thyroid, but not with thyroid disfunction. | the treatment of acute lymphoblastic leukemia (all) in children may cause sequelae, some appearing only at long-term follow-up. we investigated the thyroid gland morphology and the function of the pituitary-thyroid axis in a group of patients treated for all in childhood. | 2006 | 17008858 |
| reg i expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy. | the prognosis for patients with locally advanced thoracic esophageal cancer is extremely unfavorable. we have been administering neoadjuvant chemoradiotherapy (crt) followed by esophagectomy to these patients and studying whether reg i expression in untreated endoscopic biopsy specimens is predictive of patient responsiveness to crt and/or survival after treatment. | 2006 | 17009160 |
| synthesis of bisphosphonate derivatives of atp by t4 rna ligase. | t4 rna ligase catalyzes the synthesis of atp beta,gamma-bisphosphonate analogues, using the following substrates with the relative velocity rates indicated between brackets: methylenebisphosphonate (pch(2)p) (100), clodronate (pccl(2)p) (52), and etidronate (pc(oh)(ch(3))p) (4). the presence of pyrophosphatase about doubled the rate of these syntheses. pamidronate (pc(oh)(ch(2)-ch(2)-nh(2))p), and alendronate (pc(oh)(ch(2)-ch(2)-ch(2)-nh(2))p) were not substrates of the reaction. clodronate disp ... | 2006 | 17010342 |
| tumor characteristics and prognostic factors in two subsequent screening rounds with four-year interval within prostate cancer screening trial, erspc rotterdam. | to evaluate the tumor characteristics and prognostic factors in screen-detected prostate cancers in two successive screening rounds with a 4-year screening interval in the european randomized study of screening for prostate cancer, section rotterdam. | 2006 | 17010732 |
| gemcitabine and cisplatin in a concomitant alternating chemoradiotherapy program for locally advanced head-and-neck cancer: a pharmacology-guided schedule. | administration of gemcitabine together with cisplatin at cytotoxic doses in a chemoradiotherapy regimen is hampered by a high degree of local toxicity. using the pharmacologic properties of the drug we designed a modified schedule aimed at reducing toxicity while preserving activity. | 2006 | 17011449 |
| evaluation of ammonium perchlorate in the endocrine disruptor screening and testing program's male pubertal protocol: ability to detect effects on thyroid endpoints. | the u.s. epa endocrine disruptor screening program (edsp) tier 1 male pubertal protocol was designed as a screen to detect endocrine-disrupting chemicals which may alter reproductive development or thyroid function. one purpose of this in vivo screening protocol is to detect thyrotoxicants via a number of different mechanisms of action, such as thyroid hormone synthesis or clearance. here we evaluate the ability of this edsp male pubertal protocol to detect the known thyrotoxicant ammonium perch ... | 2006 | 17011691 |
| crystallization and preliminary x-ray analysis of bacteriophage t4 uvsy recombination mediator protein. | bacteriophage t4 uvsy protein is considered to be the prototype of recombination mediator proteins, a class of proteins which assist in the loading of recombinases onto dna. wild-type and se-substituted uvsy protein have been expressed and purified and crystallized by hanging-drop vapor diffusion. the crystals diffract to 2.4 a using in-house facilities and to 2.2 a at nsls, brookhaven national laboratory. the crystals belong to space group p422, p4(2)22, p42(1)2 or p4(2)2(1)2, the ambiguity ari ... | 2006 | 17012799 |
| [is subclinical hypothyroidism a cardiovascular risk factor?]. | subclinical hypothyroidism defined by the presence of elevated tsh levels but normal free t4 level is a common situation. its consequences on health are yet on debate and the interest of a precocious treatment remains surrounded by controversy. | 2006 | 17030490 |