Publications

hypertonic saline solution increases cerebral perfusion pressure during clinical orthotopic liver transplantation for fulminant hepatic failure: preliminary results.	during orthotopic liver transplantation for fulminant hepatic failure, some patients may develop sudden deterioration of cerebral perfusion and oxygenation, mainly due to increased intracranial pressure and hypotension, which are likely responsible for postoperative neurological morbidity and mortality. in the present study, we hypothesized that the favorable effects of hypertonic saline solution (nacl 7.5%, 4 ml/kg) infusion on both systemic and cerebral hemodynamics, demonstrated in laboratory ...	2006	16832556
hormonal regulation of mannan-binding lectin synthesis in hepatocytes.	activation of the complement system via the plasma protein mannan-binding lectin (mbl) provides a first line of defence against infections. the plasma level of mbl is, in part, determined genetically, but may also be influenced by different hormones in vivo. here we study the hormonal regulation of mbl synthesis from the human hepatocyte cell line huh-7. cells were exposed to medium with growth hormone (gh), hydrocortisone, insulin-like growth factor (igf)-1, insulin, interleukin (il)-6 or thyro ...	2006	16792688
the origin of the focal spike in musicogenic epilepsy.	to clarify the pathogenesis of a typical case of musicogenic epilepsy, we examined interictal spikes using the dipole tracing method (dtm). the patient was a 49-year-old, right-handed japanese man. he first experienced seizures at the age of 32 years; listening to his favorite piece of music frequently triggered them. his seizure type is partial (often complex, but sometimes simple). an interictal eeg examination revealed many focal spikes in f8 and t4. we estimated equivalent current dipoles (e ...	2006	16793574
the effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals.	estrogen and androgen administration modulate the pituitary-thyroid axis through alterations in thyroid hormone-binding globulin (tbg) metabolism, but the effects of sex steroids on extrathyroidal thyroxine (t4) to triiodothyronine (t3) conversion in humans are unknown.	2006	16793944
transvaginal sonography as an adjunct to endorectal sonography in the staging of rectal cancer in women.	the purpose of this study was to evaluate the contribution of transvaginal sonography (tvs) in the staging of rectal cancer in women.	2006	16794161
[effects of cardiac sympathetic blockade on left ventricular diastolic function in patients with dilated cardiomyopathy and severe heart failure].	to investigate the effects of cardiac sympathetic blockade on left ventricular diastolic function in patients with dilated cardiomyopathy and severe heart failure (hf).	2006	16796856
does marital status and marital status change predict physical health in older adults?	evidence for the effects of marital status and marital status change on physical health is equivocal.	2006	16790081
prrc-anticodon nuclease: functional organization of a prototypical bacterial restriction rnase.	the trna(lys) anticodon nuclease prrc is associated in latent form with the type ic dna restriction endonuclease ecoprri and activated by a phage t4-encoded inhibitor of ecoprri. the activation also requires the hydrolysis of gtp and presence of dttp and is inhibited by atp. the n-proximal ntpase domain of prrc has been implicated in relaying the activating signal to a c-proximal anticodon nuclease site by interacting with the requisite nucleotide cofactors [amitsur et al. (2003) mol. microbiol. ...	2006	16790566
[case of cerebral venous thrombosis due to graves' disease with increased factor viii activity].	a 39 year-old man was admitted to our hospital because of severe headache with fever continuing over two weeks. three days after admission he developed aphasia and right hemiparesis, when his ct revealed subarachnoid hemorrhage at the left sylvian fissure. he was diagnosed as suffering from cerebral venous thrombosis because empty delta sign was positive on the enhanced brain ct. suprasagittal sinus and bilateral transverse sinuses were not detected on the cerebral angiography. he was also diagn ...	2006	16768094
[case of graves' disease presenting only with rapid consciousness disturbance].	a 79-year-old woman was admitted to our hospital because of forgetfulness for a month followed with rapid development of consciousness disturbance. after admission, the depressed consciousness level fluctuated but continued for more than a month. thyroid function tests showed increased free t3 and t4 level, lowered level of tsh, and increased anti-tsh receptor antibody titer. a diagnosis of graves' disease was made but we could find none of thyrotoxic manifestations such as goiter, exophthalmos, ...	2006	16768098
[supraglottic laryngectomy. still on-going].	horizontal supraglottic laryngectomy (hsl) allows the preservation of a functioning larynx and avoids a permanent tracheostoma. its use and training have been conditioned by the employment of organ preservation programs and endoscopic laser surgery.	2006	16768202
effect of poly (2-methoxyethyl acrylate)-coated oxygenators on haemolysis.	blood contact with artificial device surfaces and mechanical trauma are two major factors for haemolysis. poly(2-methoxyethyl acrylate) (pmea) is an amphiphilic polymer with a polyethylene chain that is hydrophobic and a mildly hydrophilic tail. pmea coating has showed positive effects on protein adsorption, platelet loss, platelet aggregation and post-operative bleeding in previous studies. in this study, effects of poly(2-metoxyethyl acrylate) (pmea)-coated oxygenators on haemolysis was invest ...	2006	16768295
35-year-old woman with progressive bilateral leg weakness.	a 35-year-old woman presented with one month's history of progressive bilateral leg weakness and altered sensation. there had been no pain. she had noted urinary frequency and constipation in the previous two weeks. on examination, the patient had diffuse lower extremity weakness (2-3/5), with a t6 sensory level to pain and temperature sensation. mri demonstrated a t4-5 intradural mass ventral to the spinal cord, with an enhancing dural tail, consistent with meningioma. at surgery an intradural, ...	2006	16768759
t4 gastric carcinoma: the benefit of non-curative resection.	the prognosis of patients with gastric carcinoma with invasion of the adjacent organs (t4 gastric carcinoma) is very poor. we evaluated the survival benefit of resection in this group of patients.	2006	16768767
genistein and other soya isoflavones are potent ligands for transthyretin in serum and cerebrospinal fluid.	consumption of soya-based nutrients is increasing in modern society because of their potentially protective effects against chronic diseases. soya products are also heavily advertised as alternative drugs for relief from symptoms of the menopause and for hormone replacement therapy. however, because of their oestrogenic activity, negative effects of isoflavones have been postulated. therefore, we analysed influences of soya isoflavones, major soya constituents with endocrine activity, on thyroxi ...	2006	16768841
composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy.	mutations in the cardiac ryanodine receptor (ryr2) gene have been reported to cause arrhythmogenic right ventricular cardiomyopathy (arvc). the molecular mechanisms by which genetic modifications lead to arvc are still not well understood.	2006	16769042
[a case of hormone-refractory prostate cancer (hrpc) with tumor fever responding to docetaxel plus prednisolone therapy].	we have experienced a patient with tumor fever from hormone-refractory prostate cancer (hrpc) who was treated successfully using docetaxel plus prednisolone therapy. a 65-year-old male was diagnosed with prostate cancer (t4 n1 m1b). he received androgen-ablation therapy. but six months later he was confirmed to show failure of the previous hormone therapy and disease progression even after anti-androgen withdrawal. then docetaxel plus prednisolone therapy was started. after two courses of this t ...	2006	16770110
surgical outcome of t4a and resected t4b oral cavity cancer.	the american joint committee on cancer (ajcc) 2002 staging system (ajcc 2002) suggested that squamous cell carcinoma of the oral cavity (oscc) with t4b is unresectable. the current retrospective results show that selected t4b patients were resectable with favorable outcomes.	2006	16770782
bionanotube tetrapod assembly by in situ synthesis of a gold nanocluster with (gp5-his6)3 from bacteriophage t4.		2006	16770820
[low t3 syndrome, low t4 syndrome (euthyroid sick syndrome)].		2006	16776201
[acute hemodynamic effects of intravenous diltiazem in patients with congenital heart defects and pulmonary hypertension post cardiac surgery].	to observe the acute hemodynamic effects of intravenous diltiazem in patients with congenital heart defect (chd) and severe pulmonary hypertension (hp) post cardiac surgery.	2006	16776949
comparative evaluation between external phased array coil at 3 t and endorectal coil at 1.5 t: preliminary results.	the aim of this study was to compare the image quality and the diagnostic accuracy of endorectal coil 1.5 t mri (ermri) and phased-array coil 3 t mri (3-t mri) in the pretherapeutic staging of prostate cancer.	2006	16778606
metabolic and hemodynamic features of elderly patients undergoing beating heart coronary artery bypass graft surgery.	coronary artery bypass graft (cabg) surgery, nowadays, is increasingly performed in patients who are older and have more comorbidities than subjects operated on a decade ago. in this study, we investigated metabolic and hemodynamic features of elderly patients with single vessel coronary artery disease (cad), undergoing beating heart coronary artery bypass graft (bhcabg) surgery.	2006	16778757
thyroid hormone levels and psychological symptoms in sexually abused adolescent girls.	to explore the relationships between psychological symptoms and thyroid hormone levels in adolescent girls who had experienced the traumatic stress of sexual abuse.	2006	16781773
a selective barrier to horizontal gene transfer in the t4-type bacteriophages that has preserved a core genome with the viral replication and structural genes.	genomic analysis of bacteriophages frequently reveals a mosaic structure made up from modules that come from disparate sources. this fact has led to the general acceptance of the notion that rampant and promiscuous lateral gene transfer (lgt) plays a critical role in phage evolution. however, recent sequencing of a series of the t4-type phages has revealed that these large and complex genomes all share 2 substantial syntenous blocks of genes encoding the replication and virion structural genes. ...	2006	16782763
phase iii randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a gortec trial.	with the aim to increase the dose intensity of radiation therapy (rt), and subsequently the locoregional control rate, a very accelerated rt regimen was compared with conventional rt in a series of patients with head and neck squamous cell carcinoma (hnscc).	2006	16782926
comparative field performance over 3 years and two sites of transgenic wheat lines expressing hmw subunit transgenes.	a series of transgenic wheat lines expressing additional high molecular weight (hmw) subunit genes and the corresponding control lines were grown in replicate field trials at two uk sites (rothamsted research, approximately 50 km north of london and long ashton, near bristol) over 3 years (1998, 1999, 2000), with successive generations of the transgenic lines (t3, t4, t5) being planted. four plots from each site were used to determine grain dry weight, grain nitrogen, dough strength (measured as ...	2006	16783593
[spinal anesthesia in cesarean section with different combinations of bupivacaine and fentanyl].	the use of opioids for spinal anesthesia increases the anesthetic quality, reduces side effects and also has advantages for the postoperative analgesia. the aim of this study was to evaluate the effects of subarachnoid %0.5 hyperbaric bupivacaine (b) alone or combined with 10 or 20 mg fentanyl (f) on the anesthetic properties for cesarean section and newborn. 45 patients were randomized to three groups to receive 1.8 ml anesthetic drug for spinal anesthesia. gi (n=15) received b, gii (n=15) 10 m ...	2006	16783667
prospective multicenter trial of staging adequacy in colon cancer: preliminary results.	lymph node evaluation is an important prognostic factor in colorectal cancer (crc). a 25% recurrence rate in patients with node-negative crc suggests that current staging practices are inadequate. focused analysis of the sentinel node (sn) by multiple sectioning and immunohistochemistry improves staging accuracy.	2006	16785352
rate of pathologic complete responses to docetaxel, cisplatin, and fluorouracil induction chemotherapy in patients with squamous cell carcinoma of the head and neck.	to report the rate of pathological complete response after induction chemotherapy with the docetaxel, cisplatin, and fluorouracil (tpf) combination.	2006	16785415
estrogen effects on thyroid iodide uptake and thyroperoxidase activity in normal and ovariectomized rats.	sex steroids interfere with the pituitary-thyroid axis function, although the reports have been controversial and no conclusive data is available. some previous reports indicate that estradiol might also regulate thyroid function through a direct action on the thyrocytes. in this report, we examined the effects of low and high doses of estradiol administered to control and ovariectomized adult female rats and to pre-pubertal females. we demonstrate that estradiol administration to both intact ad ...	2006	16762383
t4-induced cardiac hypertrophy disrupts cyclic gmp mediated responses to brain natriuretic peptide in rabbit myocardium.	brain natriuretic peptide (bnp) affects the regulation of myocardial metabolism through the production of cgmp and these effects may be altered by cardiac hypertrophy. we tested the hypothesis that bnp would cause decreased metabolism and function in the heart and cardiac myocytes by increasing cgmp and that these effects would be disrupted after thyroxine-induced cardiac hypertrophy (t4). open-chest control and t4 rabbits were instrumented to determine local effects of epicardial bnp (10(-3) m) ...	2006	16762459
clinical presentation, quantitative sensory testing, and therapy of 2 patients with fourth thoracic syndrome.	the aim of the study was to describe 2 representative cases of patients presenting to an osteopathic pain practice with signs and symptoms consistent with the fourth thoracic (t4) syndrome. in addition, this article reports the application of quantitative thermosensory testing and dynamometer strength testing to confirm associated sensory and motor strength changes. nonmanipulative therapeutic interventions are reported for the first time.	2006	16762670
a novel hypothyroid dwarfism due to the missense mutation arg479cys of the thyroid peroxidase gene in the mouse.	recently, we found a novel dwarf mutation in an icr closed colony. this mutation was governed by a single autosomal recessive gene. in novel dwarf mice, plasma levels of the thyroid hormones, t3 and t4, were reduced; however, tsh was elevated. their thyroid glands showed a diffuse goiter exhibiting colloid deficiency and abnormal follicle epithelium. the dwarfism was improved by adding thyroid hormone in the diet. gene mapping revealed that the dwarf mutation was closely linked to the thyroid pe ...	2006	16762971
biomarkers of exposure and effects of environmental contaminants on swallows nesting along the rio grande, texas, usa.	we collected adult cave swallows (petrochelidon fulva) and cliff swallows (p. pyrrhonota) during the breeding seasons in 1999 and 2000 from eight locations along the rio grande from brownsville to el paso (unless otherwise specified, all locations are texas, usa) and an out-of-basin reference location. body mass, spleen mass, hepatosomatic index (hsi), gonadosomatic index (gsi), thyroxine (t4) in plasma, dna damage measured as the half-peak coefficient of variation of dna content (hpcv) in blood ...	2006	16764476
the persistent ddt metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome p4503a, and pregnane x receptor gene expressions in atlantic salmon (salmo salar) parr.	the present study investigated the effects of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (dde) on the thyroid and steroid-metabolizing system in atlantic salmon (salmo salar) parr. fish were exposed to waterborne dde and thyroxine (t4), both singly and in combination, for 5 d. thyroid-stimulating hormone (tshbeta), t4 deiodinase (t4ord), thyroid receptors (tralpha and trbeta), and insulin-like growth factor type 1 receptor (igf-1r) were analyzed using quantitative (real-time) polymerase chain ...	2006	16764480
a clinical study of the effects of rocuronium in isoflurane-anaesthetized cats.	to evaluate the neuromuscular blocking and chronotropic effects of rocuronium bromide in cats anaesthetized for surgery.	2006	16764586
the turn of the screw: variations of the abundant beta-solenoid motif in passenger domains of type v secretory proteins.	many virulence factors of gram-negative bacteria are secreted by the type v secretion system via the autotransporter (at) and two-partner secretion (tps) pathways. at proteins effect their own secretion. they comprise three domains: the amino-terminal leader sequence; the secreted passenger domain; and the translocator domain that forms the secretory channel. in the tps pathway, the passenger and translocator domains are translated as separate proteins. in a previous publication, we proposed a b ...	2006	16765057
comparative genomic hybridization reveals genetic progression of oral squamous cell carcinoma from dysplasia via two different tumourigenic pathways.	to clarify the genetic pathway(s) involved in the development and progression of oral squamous cell carcinoma (oscc), as well as the relationship between genetic aberrations and biological characteristics of oscc tumours, comparative genomic hybridization was used to analyse genetic alterations in both primary osccs and adjacent dysplastic lesions of the same biopsy specimens from 35 patients. gain of 8q22-23 was the most frequent alteration in both oscc and mild dysplasia, and was considered th ...	2006	16767698
amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality.	amiodarone-induced thyrotoxicosis (ait) is a challenging management problem, since patients treated with amiodarone invariably have underlying heart disease. consequently, thyrotoxicosis can significantly contribute to increased morbidity and mortality. the aim of this study was to compare the clinical outcome and hormone profiles of patients with ait (n = 60) with those with graves' thyrotoxicosis (n = 49) and toxic multinodular goitre (mng, n = 40).	2006	16556715
clinical inquiries. what causes a low tsh level with a normal free t4 level?		2006	16750074
should adjuvant chemotherapy become standard treatment for patients with stage ii colon cancer? for the proposal.	adjuvant chemotherapy is regarded as standard treatment for patients with stage iii colon cancer; however, use of chemotherapy after surgery in patients with stage ii disease remains controversial because of a lack of level i evidence. in 2005, the minimum clinical recommendations, issued by the european society for medical oncology (esmo), did not advocate use of chemotherapy in stage ii disease, but did state that chemotherapy "may be considered in selected node-negative patients". similarly, ...	2006	16750502
modulation of the turnover of formamidopyrimidine dna glycosylase.	in recent years, significant progress has been made in determining the catalytic mechanisms by which base excision repair (ber) dna glycosylases and glycosylase-abasic site (ap) lyases cleave the glycosyl bond. while these investigations have identified active site residues and active site architectures, few investigations have analyzed postincision turnover events. previously, we identified a critical residue (his16) in the t4-pyrimidine dimer glycosylase (t4-pdg) that, when mutated, interferes ...	2006	16752923
clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer.	to identify predictive factors for locoregional recurrence (lr), distant metastasis (dm), and overall survival (os) in patients treated with chemoradiation and surgery for rectal cancer.	2006	16755173
definitive radiotherapy for tonsillar squamous cell carcinoma.	the purpose of this study is to update our experience with definitive radiotherapy (rt) for carcinoma of the tonsillar area.	2006	16755183
[study on molecular identification and pre-harvest sprouting characteristic of the transgenic anti-trxs-gene wheat line 00t89].	pre-harvest sprouting of wheat is caused by a series of enzymes, in which alpha-amylase plays a key role. thioredoxin (trx) is an important protein capable of reducing s-s to -sh. the authors transferred the anti-trxs gene into wheat ( triticum aestivum l.) cultivar wanmai 48 in 2000 in order to obtain a transgenic line with low activities of trx and alpha-amylase in wheat seeds to enhance their resistance to pre-harvest sprouting. in this work, a pair of specific anti-trxs primers were used in ...	2006	16755924
the role of selenium in thyroid autoimmunity and cancer.	the essential micronutrient selenium (se) occurs in the form of the amino acid selenocysteine in selenoproteins which exert various effects, while maintaining the cell reduction-oxidation balance. the discovery that all three deiodinases that convert thyroxine (t4) into triiodothyronine (t3) contain selenocysteine illustrates how the production of the active thyroid hormone is dependent on se status. the selenoenzyme families of glutathione peroxidases (gpx) and thioredoxin reductases (trx) poss ...	2006	16756467
successful in utero treatment of fetal goitrous hypothyroidism: case report and review of the literature.	in this report, we present a case of fetal goiter with overdistended fetal neck and mild polyhydramnios. amniocentesis and cordocentesis were conducted at 32 weeks' gestation and fetal goitrous hypothyroidism was diagnosed. intra-amniotic injection of l-thyroxine (t4) was performed with a weekly dose of 150 microg four times between 33 and 36 weeks' gestation. in response to this in utero treatment, the goiter was reduced and polyhydramnios was improved. the mother gave birth to a healthy live m ...	2006	16757912
[prognostic value of splenectomy and lymph-node dissection during gastric cancer resection].	gastric carcinoma is the second most common cause of digestive tumour-related death in europe, north america and asia. today, the gold standard of treatment is still surgery, but outcomes to date are unsatisfactory. the japanese society for research in gastric cancer (jsrgc) recommends the routine execution of splenectomy during gastrectomy. this recommendation is contested by western authors because of increased morbidity and mortality without any real advantage in terms of survival. patients t ...	2006	16734164
real-time quantitative analysis for human telomerase reverse transcriptase mrna and human telomerase rna component mrna expressions as markers for clinicopathologic parameters in urinary bladder cancer.	the expression of the telomerase subunits such as human telomerase reverse transcriptase (htert) and human telomerase rna component (htr) may be associated with tumor development and progression. we evaluated the relationship between mrna quantification of both htert and htr and clinicopathologic parameters in bladder cancer.	2006	16734859
plasmacytoid urothelial carcinoma of the bladder.	we report the first case of a pathological complete response for plasmacytoid urothelial carcinoma of the bladder. a 76-year-old man was diagnosed with plasmacytoid urothelial carcinoma (t4, n0, m0) by the microscopically plasmacytoid appearance of the specimen from the transurethral resection. immunohistochemical studies were positive for epithelial markers and negative for lymphoid markers. two cycles of systemic chemotherapy were performed with methotrexate, etoposide, vinblastine, and cispla ...	2006	16734884
[injury to major blood vessels in anterior thoracic and lumbar spinal surgery].	the anterior approach to the thoracic and lumbar spine is used with increasing frequency for various indications. with the advent of prosthetic intervertebral disc replacement, its use has become even more frequent and has often been associated with serious complications. the aim of this study was to evaluate vascular complications in patients who underwent anterior spinal surgery of the thoracic and lumbar spine.	2006	16735005
sanguinarine overcomes p-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in cem-vlb 1000 cells.	permeability-glycoprotein (pgp) positive cells are known to be encoded by the multidrug-resistance gene (mdr1), and characterized by a reduced ability to accumulate drugs. the vinblastin-resistant, pgp positive cem-vlb 1000 and its wild type (pgp-negative and vinblastin-sensitive) counterpart cem-t4 human leukemia cells, when treated with the alkaloid sanguinarine, were both found to undergo apoptosis at concentrations of 1.5 microg/ml and oncosis/blister cell death (bcd) at concentrations of 12 ...	2006	16735106
adenoid cystic carcinoma of the sinonasal tract: treatment results.	malignancies arising from the sinonasal tract, which includes the nose, paranasal sinuses, and nasopharynx, are uncommon. although adenoid cystic carcinoma (acc) is the second most common cancer occurring in the sinonasal tract, only few studies have been reported. this retrospective review was performed to identify the clinical features and treatment outcomes of sinonasal acc.	2006	16735899
biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase i-ii study.	oxaliplatin (oxa), raltitrexed (rtx), 5-fluorouracil (fu) and folinic acid (fa) have shown activity in metastatic colorectal cancer, radioenhancing effect and synergism when combined. we evaluated a chemotherapy (ct) combination of oxa, rtx and fu/fa during preoperative radiotherapy (rt) in locally advanced rectal cancer (larc) patients. fifty-one patients with larc at high risk of recurrence (t4, n+ or t3n0 < or =5 cm from anal verge and/or circumferential resection margin < or =5 mm) received ...	2006	16736001
ruminal drinkers: endocrine and metabolic status and effects of suckling from a nipple instead of drinking from a bucket.	in ruminal drinkers (rd) ingested milk is transported into the rumen and not into the abomasum. because this is followed by changes in digestibility and absorption, we have tested whether this is associated with postprandial metabolic and endocrine changes. unweaned, bucket-fed calves (one rd, two controls) were studied on seven farms. on d 1, after metabolic and endocrine 12-h profiles were studied, rd and one control calf were fed for 10 d by nipple, whereas the other control calf was fed by b ...	2006	16737510
[surgical therapeutic strategy for non-small cell lung cancer with (n2) mediastinal lymph node metastasis].	to evaluate the surgical therapeutic strategy for non-small cell lung cancer (nsclc) with (n2) mediastinal lymph node metastasis.	2006	16737625
displacement of a dna binding protein by dda helicase.	bacteriophage t4 dda helicase has recently been shown to be active as a monomer for unwinding of short duplex oligonucleotides and for displacing streptavidin from 3'-biotinylated oligonucleotides. however, its activity for streptavidin displacement and dna unwinding has been shown to increase as the number of dda molecules bound to the substrate molecule increases. a substrate was designed to address the ability of dda to displace dna binding proteins. a dna binding site for the escherichia col ...	2006	16738140
recovery from vecuronium is delayed in patients with hypercholesterolemia.	to examine the effects of hypercholesterolemia with respect to onset time and recovery from vecuronium-induced neuromuscular block.	2006	16738289
[results of multivisceral resection of primary colorectal cancer].	in about 10 % of all patients with colorectal cancer, the primary invention already discloses adhesions or infiltration of adjacent organs. en bloc resection of the tumor-bearing bowel segment with adjacent organs is done to give patients a chance for curation, since intraoperative differentiation is not possible. the aim of this study is characterization of the patient population as well as evaluation of the morbidity and mortality associated with this type of extensive intervention.	2006	16739062
single-institute phase i/ii trial of alternating chemoradiotherapy with 5-fu and nedaplatin for esophageal carcinoma.	to assess the efficacy and feasibility of alternating chemoradiotherapy for esophageal cancer.	2006	16739307
location and age at onset of colorectal cancer in hungarian patients between 1993 and 2004. the high number of advanced cases supports the need for a colorectal cancer screening program in hungary.	in recent decades, the incidence of proximal colorectal cancer (crc) in north america and western europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of crc cases over the last 12 years in a large number of hungarian patients.	2006	16739314
anterior decompression for cervicothoracic pathology: a study of 14 patients.	various anterior approaches to the cervicothoracic junction have been described. this study reports our experience with 14 patients who had cervical anterior approaches to the cervicothoracic junction (c6-t2). this technique was evaluated with regard to the extent of exposure, ease of technique, and postoperative morbidity. we have chosen the low cervical approach to obtain exposure up to t2. for t3-t4 pathology, we use the transthoracic, periscapular approach. we do not practice bone-splitting ...	2006	16739561
[characteristics of the parietal cortex activation in humans during different attention tasks].	the cortical activation was estimated by the event-related potential (erps) methods during selection tasks of lateralized visual stimuli requiring different forms of attention: 1) form of stimuli, 2) stimuli position, 3) combined attention of form and position. the erps were recorded in 15 young healthy adults in 6 leads p3, p4, t3, t4, t5, t6, and endogenous erps components: cnv (contingent negative variation), n1, p3 and the complex [n1-p3]. differences between the erps at "attended" and "non- ...	2006	16739651
hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in t2 gastric cancer.	abnormal hemostasis in cancer patients has previously been described, however the correlation between the plasma fibrinogen level and cancer metastasis and prognosis has not been reported in a large-scale clinical study.	2006	16740157
association of elevated free t4 levels with depressive symptoms in patients with psychotic disorders.		2006	16740376
once daily sublingual immunotherapy without updosing--a new treatment schedule.	treatment regimens with specific immunotherapy include updosing. due to excellent tolerance of sublingual immunotherapy (slit), it was hypothesized that administration of once-daily slit could be initiated safely without updosing. the objective was to evaluate tolerability of slit administered once daily without updosing.	2006	16741368
the diagnostic value of multiplanar reconstruction on mdct colonography for the preoperative staging of colorectal cancer.	the purpose of this study was to determine whether multiplanar reconstruction (mpr) images can improve the accuracy of mdct-based colorectal cancer preoperative staging by receiver-operating characteristic (roc) analysis. fifty-five patients with colorectal cancer underwent contrast-enhanced ct colonography using an 8- or 16-row scanner. two separate interval reviews of the axial mdct datasets with/without mpr images (coronal and sagittal) were performed independently by two radiologists blinded ...	2006	16741717
stereocontrolled and convergent total synthesis of amphidinolide t3.	stereocontrolled and convergent total synthesis of amphidinolide t3 has been described. a retrosynthetic scheme was constructed that led to the recognition of readily available and enantiomerically related compounds as starting materials for the total synthesis of amphidinolide t3. thus, the two key building blocks 6 and 7 were defined as subtargets and synthesized in optically active forms. the c1-c12 fragment 6 was derived from commercially available d-glutamic acid or its synthetically equiva ...	2006	16749797
cervical osteotomy in ankylosing spondylitis: evaluation of new developments.	cervical osteotomy can be performed on patients with cervical kyphosis due to ankylosing spondylitis. this study reviews the role of two new developments in cervical osteotomy surgery: internal fixation and transcranial electrical stimulated motor evoked potential monitoring (tes-mep).	2006	15928952
intensity-modulated radiation therapy (imrt) for nasopharynx cancer: update of the memorial sloan-kettering experience.	we previously demonstrated that intensity-modulated radiation therapy (imrt) significantly improves radiation dose distribution over three-dimensional planning for nasopharynx cancer and reported positive early clinical results. we now evaluate whether imrt has resulted in improved outcomes for a larger cohort of patients with longer follow-up.	2006	15936155
glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia.	the aim of this article is to investigate the prevalence of glucose-6-phosphate dehydrogenase (g6pd) deficiency in neonatal hyperbilirubinemia and to compare the clinical presentation and course of g6pd-deficient and normal patients. this study included a total of 624 term neonates with indirect hyperbilirubinemia from march 2001 to september 2004. birth weight, sex, weight at admission, serum bilirubin at admission, maximum bilirubin, phototherapy duration, duration of hospitalization and the n ...	2006	15917260
psychological adjustment of parents of pediatric cancer patients revisited: five years later.	we investigated the psychological functioning of parents of children suffering from pediatric cancer using a prospective design over a five-year time period. parents of children diagnosed with cancer participated at diagnosis (t1), six months (t2), twelve months (t3), and five years later (t4, n = 115). repeated measures anovas were calculated for the three measures of psychological distress (ghq, scl-90 and stai-s) to examine changes over time and gender differences. independent t-tests were co ...	2006	15880477
can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for t3-t4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision?	local excision is considered inappropriate treatment for t3-t4 rectal adenocarcinomas, as it cannot provide prognostic information regarding lymph node involvement and has a high risk of pelvic recurrence. preoperative chemoradiation (crt) studies in rectal cancer suggest that a pathological complete response (pcr) in the primary tumour provides an excellent long-term outcome. if downstaging to stage pt0 predicts a tumour response within the perirectal and pelvic lymph nodes, this may allow loca ...	2006	15864605
analysis of thyroid hormone receptor betaa mrna expression in xenopus laevis tadpoles as a means to detect agonism and antagonism of thyroid hormone action.	amphibian metamorphosis represents a unique biological model to study thyroid hormone (th) action in vivo. in this study, we examined the utility of thyroid hormone receptors alpha (tralpha) and betaa (trbetaa) mrna expression patterns in xenopus laevis tadpoles as molecular markers indicating modulation of th action. during spontaneous metamorphosis, only moderate changes were evident for tralpha gene expression whereas a marked up-regulation of trbetaa mrna occurred in hind limbs (prometamorph ...	2006	16040072
iatrogenic fractures in ankylosing spondylitis--a report of two cases.	two cases of intraoperative, iatrogenic cervical spine fractures in patients with ankylosing spondylitis are reported.	2006	16032433
adjusted leptin level (all) is a predictor for hyperemesis gravidarum.	to compare the maternal serum leptin level according to the gestational week and to assess the relationship between the adjusted serum leptin level and thyroid hormones. in order to obtain this objective a new parameter is developed: adjusted leptin level (all: maternal serum leptin level/gestational week).	2006	16051421
genetic diversity and origin of chinese cattle revealed by mtdna d-loop sequence variation.	to determine the origin and genetic diversity of chinese cattle, we analyzed the complete mtdna d-loop sequences of 84 cattle from 14 breeds/populations from southwest and west china, together with the available cattle sequences in genbank. our results showed that the chinese cattle samples converged into two main groups, which correspond to the two species bos taurus and bos indicus. although a dominant lineage was clearly discerned in both b. taurus and b. indicus mtdnas, network analysis of t ...	2006	16054846
oropharyngeal carcinoma and its treatment in finland between 1995-1999: a nationwide study.	the survival figures for advanced stage oropharyngeal carcinoma (opc) have remained moderate in spite of radical combined modality treatments. the purpose of this study was to investigate the used treatment approach and the outcome of opc in a nationwide study. retrospective clinicopathological data of all patients diagnosed with opc between 1995 and 1999 at the five university hospitals in finland were reviewed. all patients had a minimum 4-year follow-up. a total of 168 patients (145 men and 2 ...	2006	16003551
correlation between mr imaging-derived nasopharyngeal carcinoma tumor volume and tnm system.	to measure nasopharyngeal carcinoma tumor volume based on magnetic resonance images using a validated semiautomated measurement methodology and correlate tumor volume with tnm t classification.	2006	16271442
large-scale systematic study on stability of the ds element and timing of transposition in rice.	activator/dissociation (ac/ds) transposon mutagenesis is a widely used tool for gene identification; however, several reports on silencing of the ac/ds element in starter lines and in stable transposants question the applicability of such an approach in later generations. we have performed a systematic analysis on various aspects of the silencing phenomenon in rice (oryza sativa ssp. japonica cv. nipponbare). high somatic and germinal transposition frequencies observed in earlier generations wer ...	2006	16275658
molecular architecture and ligand recognition determinants for t4 rna ligase.	rna ligase type 1 from bacteriophage t4 (rnl1) is involved in countering a host defense mechanism by repairing 5'-po4 and 3'-oh groups in trna(lys). rnl1 is widely used as a reagent in molecular biology. although many structures for dna ligases are available, only fragments of rna ligases such as rnl2 are known. we report the first crystal structure of a complete rna ligase, rnl1, in complex with adenosine 5'-(alpha,beta-methylenetriphosphate) (ampcpp). the n-terminal domain is related to the eq ...	2006	16263720
neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment.	our objective was to examine the relation between neuropsychological function and subclinical hypothyroidism (sht), defined as serum tsh of 3.5-10.0 miu/liter and normal serum free t4 and free t3 levels, and to study the effect of t4 supplementation.	2006	16263815
survival and death causes in differentiated thyroid carcinoma.	survival studies in differentiated thyroid carcinoma (dtc) may be biased because they have been performed in heterogeneous populations. in addition, specific death causes in dtc have not been documented well in the literature.	2006	16263822
its1 sequence variabilities correlate with 18s rdna sequence types in the genus acanthamoeba (protozoa: amoebozoa).	the subgenus classification of the ubiquitously spread and potentially pathogenic acanthamoebae still poses a great challenge. fifteen 18s rdna sequence types (t1-t15) have been established, but the vast majority of isolates fall into sequence type t4, and so far, there is no means to reliably differentiate within t4. in this study, the first internal transcribed spacer (its1), a more variable region than the 18s rrna gene, was sequenced, and the sequences of 15 different acanthamoeba isolates w ...	2006	16261355
activation of adenosine a(1) receptors alters behavioral and biochemical parameters in hyperthyroid rats.	adenosine acting on a(1) receptors has been related with neuroprotective and neuromodulatory actions, protection against oxidative stress and decrease of anxiety and nociceptive signaling. previous studies demonstrated an inhibition of the enzymes that hydrolyze atp to adenosine in the rat central nervous system after hyperthyroidism induction. manifestations of hyperthyroidism include increased anxiety, nervousness, high o(2) consumption and physical hyperactivity. here, we investigated the eff ...	2006	16257062
preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathologic complete response, local recurrence-free survival, disease-free survival, and overall survival.	three phase ii studies of preoperative radiotherapy and concurrent 5fu chemotherapy were undertaken. the primary endpoints were acute toxicity and pathologic complete response rate (pcr). secondary endpoints were local recurrence-free survival (lrfs), disease-free survival (dfs), and overall survival (os).	2006	16242252
psychological distress and the impact of social support on fathers and mothers of pediatric cancer patients: long-term prospective results.	to explore the effects of social support on psychological distress of parents of pediatric cancer patients using a prospective design over a 5-year period.	2006	16251479
the loss of the chloride channel, clc-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.	genetic inactivation of clc-5, a voltage-gated chloride channel prominently expressed in the kidney, leads to proteinuria because of defective apical endocytosis in proximal tubular cells. because thyroid hormone secretion depends on apical endocytosis of thyroglobulin (tg), we investigated whether clc-5 is expressed in the thyroid and affects its function, using clcn5-deficient knockout (ko) mice. we found that clc-5 is highly expressed in wild-type mouse thyroid ( approximately 40% of mrna kid ...	2006	16306076
effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.	retinoid x receptor (rxr)-selective retinoids (rexinoids) can cause central hypothyroidism in humans, and this effect has been confirmed in rodent models. in this report, we characterized the effect of rexinoids on the hypothalamic-pituitary-thyroid axis in mice and tsh regulation in a thyrotrope-derived cell line. the synthetic rexinoid (lg 268) suppressed tsh and t4 levels in mice. hypothalamic trh mrna was unaffected, but steady-state pituitary tshbeta mrna levels were significantly lowered, ...	2006	16306084
mechanism of the phosphatase component of clostridium thermocellum polynucleotide kinase-phosphatase.	polynucleotide kinase-phosphatase (pnkp) from clostridium thermocellum catalyzes atp-dependent phosphorylation of 5'-oh termini of dna or rna polynucleotides and ni(2+)/mn(2+)-dependent dephosphorylation of 2',3' cyclic phosphate, 2'-phosphate, and 3'-phosphate ribonucleotides. cthpnkp is an 870-amino-acid polypeptide composed of three domains: an n-terminal module similar to bacteriophage t4 polynucleotide kinase, a central module that resembles the dinuclear metallo-phosphoesterase superfamily ...	2006	16301605
preoperative chemoradiation for rectal cancer causes prolonged pudendal nerve terminal motor latency.	a worsened anorectal function after chemoradiation for high-risk rectal cancer is often attributed to radiation damage of the anorectum and pelvic floor. its impact on pudendal nerve function is unclear. this prospective study evaluated the short-term effect of preoperative combined chemoradiation on anorectal physiologic and pudendal nerve function.	2006	16292664
possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds.	the photoperiodic response of the gonads requires t3, which is generated photoperiodically from t4 by type 2 iodothyronine deiodinase in the hypothalamus. although thyroid hormones were long thought to traverse the plasma membrane by passive diffusion due to their lipophilic nature, it is now known that several organic anion transporting polypeptides (oatp) transport thyroid hormones into target cells. in this study, we have used database searches to isolate dna sequences encoding members of the ...	2006	16293658
evaluation of gene expression endpoints in the context of a xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors.	thyroid hormones (th) are important in growth, development and the maintenance of proper cellular metabolism in vertebrates. amphibian metamorphosis is completely dependent on th and forms the basis of a screen for thyroid axis disrupting chemicals that currently relies on external morphological endpoints and changes in thyroid gland histology. the requirement for th-dependent gene expression makes it possible to augment this screen through the addition of molecular endpoints. in order to do thi ...	2006	16289343
topography of eeg complexity in human neonates: effect of the postmenstrual age and the sleep state.	the topography of the eeg of human neonates is studied in terms of its power spectral density and its estimated complexity as a function of both the postmenstrual age (pma) and the sleep state. the monopolar eegs of three groups of seven neonates (preterm, term and older term) were recorded during active (as) and quiet sleep (qs) from electrodes fp1, fp2, t3, t4, c3, c4, o1 and o2. the existence of changes between groups and sleep states in the power of delta, theta, alpha and beta bands and in ...	2006	16278043
functional analysis of the bacteriophage t4 dna-packaging atpase motor.	packaging of double-stranded dna into bacteriophage capsids is driven by one of the most powerful force-generating motors reported to date. the phage t4 motor is constituted by gene product 16 (gp16) (18 kda; small terminase), gp17 (70 kda; large terminase), and gp20 (61 kda; dodecameric portal). extensive sequence alignments revealed that numerous phage and viral large terminases encode a common walker-b motif in the n-terminal atpase domain. the gp17 motif consists of a highly conserved aspart ...	2006	16258174
capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase ii study.	the aim of the study was to evaluate tolerance and efficacy of preoperative treatment with capecitabine in combination with radiation therapy (rt) in patients with locally advanced, resectable, rectal cancer.	2006	16282246
possible association between phages, hoc protein, and the immune system.	mammals have become "an environment" for enterobacterial phage life cycles. therefore it could be expected that bacteriophages adapt to them. this adaptation must comprise bacteriophage proteins. gp hoc seems to have significance neither for phage particle structure nor for phage antibacterial activity. it is evidently not necessary for the "typical" antibacterial actions of bacteriophages. but the rules of evolution make it improbable that gp hoc really has no function, and non-essential genes ...	2006	16195787
effects of supplementation of beta-glucan on the growth performance and immunity in broilers.	two experiments were conducted to evaluate the efficacy of beta-glucan on commercial broilers. in experiment 1, one hundred and forty-four broiler chicks were employed in a 2x3 factorial design with cage and open floor housing with three levels of beta-glucan viz. 0%, 0.02% and 0.04%. in experiment 2, ninety-six broilers were used with 4 treatments: no beta-glucan and antibiotic (t1), beta-glucan 0.03% (t2), antibiotic (t3), and beta-glucan 0.03% + antibiotic (t4) for 34 d with 3 replicates of 8 ...	2006	16165172
a cdna for a putative type iii deiodinase in the trout (oncorhynchus mykiss): influence of holding conditions and thyroid hormone treatment on its hepatic expression.	a putative rainbow trout type iii deiodinase (d3) cdna was amplified by pcr, using primers to evolutionarily conserved sequences. the race-derived complete cdna was then identified by sequence comparison to that in tilapia and other vertebrates. the cdna coded for a predicted 31,500 kda protein of 278 amino acids, with a hydrophobic trans-membrane segment and with 80% similarity to tilapia d3 and 39% similarity to rainbow trout type ii deiodinase (d2). it also showed a selenocysteine codon at po ...	2006	16214142