Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| recognition of pore-forming colicin y by its cognate immunity protein. | construction of hybrid immunity genes between colicin u (cui) and y (cyi) immunity genes and site-directed mutagenesis of cyi were used to identify amino-acid residues of the colicin y immunity protein (cyi) involved in recognition of colicin y. these amino-acid residues were localized close to the cytoplasmic site of the cyi transmembrane helices t3 (s104, s107, f110, a112) and t4 (a159). mutations in cui, which converted cui sequence to cyi sequence in positions 104, 107, 110, 112 and 159, res ... | 2006 | 16630264 |
| treatment of squamous cell anal canal carcinoma (scacc) with pulsed dose rate brachytherapy: a retrospective study. | to evaluate the results of pulsed dose rate brachytherapy (pdr) in scacc. | 2006 | 16631268 |
| interrelationship of hepatic function, thyroid activity and mood status in alcohol-dependent individuals. | alcohol-induced changes in thyroid function may contribute to the development of mood disorders such as depression and anxiety that almost invariably coexist in alcohol-dependent individuals. the aim of the present study was to investigate the severity of liver dysfunction and thyroid activity in correlation with anxiety and depressive-like symptomatology before and after a detoxification period. | 2006 | 16634533 |
| mechanism of presynaptic filament stabilization by the bacteriophage t4 uvsy recombination mediator protein. | uvsy is the recombination mediator protein (rmp) of bacteriophage t4, which promotes homologous recombination by facilitating presynaptic filament assembly. the results of previous studies suggest that uvsy promotes the assembly of presynaptic filaments in part by stabilizing interactions between t4 uvsx recombinase and single-stranded dna (ssdna). to test this hypothesis, we studied the interactions of uvsx and uvsy with a fluorescein-derivatized oligonucleotide. this assay distinguishes betwee ... | 2006 | 16634631 |
| phase i/ii study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer: cancer and leukemia group b 89901. | the addition of oxaliplatin to fluorouracil in patients with advanced colorectal cancer improves survival. this phase i/ii study evaluated the addition of weekly oxaliplatin to preoperative continuous infusion fluorouracil (fu) and external-beam radiation therapy (rt) in patients with locally advanced rectal adenocarcinoma. | 2006 | 16636336 |
| repeated pulmonary rehabilitation in severe and disabled copd patients. | the optimal frequency of delivering a pulmonary rehabilitation program (pr) is not yet a well established issue. it is still unclear whether repeated pr at established intervals will result in effective maintenance or further improvement in the patient's health status. | 2006 | 16636528 |
| [establishment of murine cell line transfected with human cd14 gene]. | this study was aimed to construct the cd14 eukaryotic expression vector, establish the transgeneic cd14 positive cell line in order to facilitate the establishment of a mouse model of antibody targeting therapy for human acute monocytic leukemia (aml-m(5)). total rna extracted from peripheral blood mononuclear cells was treated with rnaase-free dnaase, the human cd14 gene was cloned and sequenced through the rt-pcr and t-a clone techniques. eukaryotic expressional vector pcdna3.1(+)/cd14 was con ... | 2006 | 16638222 |
| evaluation of ionized and total serum magnesium concentrations in hyperthyroid cats. | hyperthyroidism can increase the renal excretion of magnesium and thus cause hypomagnesemia in various species. anaerobically collected blood samples from 15 hyperthyroid and 40 normal, healthy cats were analyzed with an ion-selective electrode analyzer and a serum biochemical analyzer. there was no significant difference in ionized or total serum magnesium concentration between the 2 groups, but there was a significant difference (p = 0.004) in the ratio of ionized to total serum magnesium conc ... | 2006 | 16639946 |
| measurement of free thyroxine concentration in horses by equilibrium dialysis. | the purpose of the study reported here was to validate measurement of free thyroxine (ft4) concentration in equine serum by equilibrium dialysis (ft4d), and to compare values with ft4 concentration measured directly and with total t4 (tt4) concentration. the ft4d, ft4, and tt4 concentrations were measured over a range of values in euthyroid horses and horses made hypothyroid by administration of propylthiouracil (ptu). concentrations of ft4d (<1.8-83 pmol/l) were consistently higher than those o ... | 2006 | 16594596 |
| tandem mass spectrometry of intact groel-substrate complexes reveals substrate-specific conformational changes in the trans ring. | it has been suggested that the bacterial groel chaperonin accommodates only one substrate at any given time, due to conformational changes to both the cis and trans ring that are induced upon substrate binding. using electrospray ionization mass spectrometry, we show that indeed groel binds only one molecule of the model substrate rubisco. in contrast, the capsid protein of bacteriophage t4, a natural groel substrate, can occupy both rings simultaneously. as these substrates are of similar size, ... | 2006 | 16594706 |
| bacteriophage replication modules. | bacteriophages (prokaryotic viruses) are favourite model systems to study dna replication in prokaryotes, and provide examples for every theoretically possible replication mechanism. in addition, the elucidation of the intricate interplay of phage-encoded replication factors with 'host' factors has always advanced the understanding of dna replication in general. here we review bacteriophage replication based on the long-standing observation that in most known phage genomes the replication genes ... | 2006 | 16594962 |
| phase ii study of neoadjuvant docetaxel/ vinorelbine followed by surgery and adjuvant doxorubicin/cyclophosphamide in women with stage ii/iii breast cancer. | the purpose of this study was to evaluate the combination of docetaxel plus vinorelbine as neoadjuvant chemotherapy for stage ii/iii locally advanced breast cancer. | 2006 | 16595034 |
| sequential reorganization of beta-sheet topology by insertion of a single strand. | insertions, duplications, and deletions of sequence segments are thought to be major evolutionary mechanisms that increase the structural and functional diversity of proteins. alternative splicing, for example, is an intracellular editing mechanism that is thought to generate isoforms for 30%-50% of all human genes. whereas the inserted sequences usually display only minor structural rearrangements at the insertion site, recent observations indicate that they may also cause more dramatic structu ... | 2006 | 16597830 |
| [effect of excessive iodine exposure on the serum tc and tg level in rats]. | to study effect of excessive iodine exposure on the serum tc and tg level in rate. | 2006 | 16598951 |
| coexistence of peripheral primitive neuroectodermal tumor and tetralogy of fallot. | we describe a little girl with tetralogy of fallot (tof) who was found to have a huge peripheral primitive neuroectodermal tumor (ppnet) when she developed progressive difficulty in standing and crawling at the age of 11 months. the tumor was located in the left paraspinal region (t4-t12), with intraspinal extension causing severe compression. nine days after surgical decompression with laminectomy, chemotherapy was initiated with alternative courses of vincristine, doxorubicin, cyclophosphamide ... | 2006 | 16599020 |
| guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered t4 lysozyme. | the binding of guanidinium ion has been shown to promote a large-scale translation of a tandemly duplicated helix in an engineered mutant of t4 lysozyme. the guanidinium ion acts as a surrogate for the guanidino group of an arginine side chain. here we determine whether methyl- and ethylguanidinium provide better mimics. the results show that addition of the hydrophobic moieties to the ligand enhances the binding affinity concomitant with reduction in ligand solubility. crystallographic analysis ... | 2006 | 16600969 |
| a study on staging bone scans in newly diagnosed prostate cancer. | this study aimed to evaluate the role of bone scan as a staging investigation in newly diagnosed untreated prostate cancers. | 2006 | 16601380 |
| the role of an upstream promoter interaction in initiation of bacterial transcription. | the bacterial rna polymerase (rnap) recognizes promoters through sequence-specific contacts of its promoter-specificity components (sigma) with two dna sequence motifs. contacts with the upstream ('-35') promoter motif are made by sigma domain 4 attached to the flap domain of the rnap beta subunit. bacteriophage t4 late promoters consist solely of an extended downstream ('-10') motif specifically recognized by the t4 gene 55 protein (gp55). low level basal transcription is sustained by gp55-rnap ... | 2006 | 16601684 |
| the clinical impact of histopathologic response assessment by residual tumor cell quantification in esophageal squamous cell carcinomas. | the objectives of this study were to investigate histomorphologic features as a response classification after neoadjuvant radiochemotherapy (rtx/ctx) and to correlate the results with clinical outcome parameters (e.g., postoperative morbidity and mortality, recurrence, and survival) in patients with locally advanced esophageal squamous cell carcinoma (escc). | 2006 | 16607651 |
| improved quality of life after sympathetic block for upper limb hyperhidrosis. | the aim of the study was to assess two disease-specific quality of life (qol) instruments after limited endoscopic thoracic sympathetic block (ts) at t4 for upper limb hyperhidrosis. | 2006 | 16607680 |
| telomerase subunit immunoreactivity and recurrence in colorectal cancer. | telomerase is expressed in human germ tissues and in the majority of primary human tumors. the catalytic subunit of telomerase, htert is one of the most important components of telomerase. in this study we attempted to show by means of immunohistochemistry the association between htert expression and recurrence in 128 colorectal cancer patients surgically treated in the university of tokyo hospital. | 2006 | 16608021 |
| [a comparative study on the resistance of bacteriophage t4, phixm174d, and f2 to glutaraldehyde in laboratory]. | to identify the best indicative bacteriophage in disinfection tests through comparing the resistance of bacteriophage t4, phix174d, and f2 to glutaraldehyde. | 2006 | 16608092 |
| actual practice vs guidelines in laboratory monitoring of older patients with primary hypothyroidism in primary care. | clinical guidelines are produced in order to achieve an acceptable standard of care, especially for patients with common diseases in primary care. the treatment of primary hypothyroidism serves as an example of the content of clinical guidelines and actual practice. the aim of this study was to compare the follow-up of primary hypothyroidism by thyroid function tests, serum tsh and serum-free t4, in older patients managed in primary care, with recommendations in treatment guidelines and textbook ... | 2006 | 16608134 |
| [maxillary sinus cancers: prognosis and quality of life: a retrospective study of 22 cases]. | maxillary sinus cancer is uncommon. we present a study of 22 cases of patients managed at the nantes university hospital for maxillary sinus cancer during the time period 1989-2002. | 2006 | 16609666 |
| neurobehavioral effects and hormones profile among spray painters. | a cross-sectional study was conducted in 25 spray painters and 35 control subjects to evaluate neurobehavioral function, and thyroid and reproductive hormones profile. this study indicated higher prevalence of psychological and neurological symptoms, and clinical findings among spray painters when compared with controls. levels of tsh were significantly (p<0.01) elevated in spray painters over the control group (3.04 +/- 1.53 vs 1.88 +/- 1.07 microiu/ml, mean +/- sd), respectively. two of the 25 ... | 2006 | 16610541 |
| identifying illness parameters in fatiguing syndromes using classical projection methods. | to examine the potential of multivariate projection methods in identifying common patterns of change in clinical and gene expression data that capture the illness state of subjects with unexplained fatigue and nonfatigued control participants. | 2006 | 16610951 |
| treatment of head and neck dermatitis with ciclopiroxolamine cream--results of a double-blind, placebo-controlled study. | in atopic dermatitis, microbial allergens may be pathogenetically significant. apart from staphylococcus aureus, these are primarily lipophilic malassezia yeasts. they are particularly involved in the pathogenesis of head and neck dermatitis (hnd), a special form of atopic dermatitis, which is often difficult to treat. fifty patients (21 men, 29 women) with moderate to severe hnd of at least 6 months' duration were included in a prospective double-blind study. all of them showed at least 10% inv ... | 2006 | 16612143 |
| [preoperative and palliative embolization of renal cell carcinomas: follow-up of 49 patients]. | to evaluate the influence of preoperative and palliative embolization of renal cell carcinomas on survival, intra- and post-operative procedures, and symptom control for palliative and preoperative indications. | 2006 | 16612730 |
| hypercholesterolemia and tissue-specific differential mrna expression of type-1 5'-iodothyronine deiodinase under different selenium status in rats. | type-1 5'-iodothyronine deiodinase (5'-di) is responsible for conversion of t4 to t3. selenium (se) is an integral part of this enzyme. keeping in view the strong association between atherosclerosis and hypothyroidism, the present study examined the behavior of 5'-di in liver, aorta and thyroid during hypercholesterolemia following different se status, i.e., se deficiency (0.02 ppm), adequate (0.2 ppm) and excess dose (1 ppm) in sd male rats. animals were fed a control or high-cholesterol diet ( ... | 2006 | 16874406 |
| [construction and identification of a multiple myeloma-specific ape1 sirna expression vector]. | to construct a multiple myeloma (mm)-specific ape1sirna expression vector, and detect the specific knock-down effect of the sirna on expression of ape1 protein. | 2006 | 16875553 |
| hypothalamic thyroid hormone feedback in health and disease. | the role of the human hypothalamus in the neuroendocrine response to illness has only recently begun to be explored. extensive changes in the hypothalamus-pituitary-thyroid (hpt) axis occur within the framework of critical illness. the best-documented change in the hpt axis is a decrease in serum concentrations of the biologically active thyroid hormone triiodothyronine (t3). from studies in post-mortem human hypothalamus it appeared that low serum t3 and thyrotropin (tsh) during illness (nonthy ... | 2006 | 16876576 |
| the trh neuron: a hypothalamic integrator of energy metabolism. | thyrotropin-releasing hormone (trh) has an important role in the regulation of energy homeostasis not only through effects on thyroid function orchestrated through hypophysiotropic neurons in the hypothalamic paraventricular nucleus (pvn), but also through central effects on feeding behavior, thermogenesis, locomotor activation and autonomic regulation. hypophysiotropic trh neurons are located in the medial and periventricular parvocellular subdivisions of the pvn and receive direct monosynaptic ... | 2006 | 16876577 |
| bacteriophage t5 structure reveals similarities with hk97 and t4 suggesting evolutionary relationships. | evolutionary relationships between viruses may be obscure by protein sequence but unmasked by structure. analysis of bacteriophage t5 by cryo-electron microscopy and protein sequence analysis reveals analogies with hk97 and t4 that suggest a mosaic of such connections. the t5 capsid is consistent with the hk97 capsid protein fold but has a different geometry, incorporating three additional hexamers on each icosahedral facet. similarly to hk97, the t5 major capsid protein has an n-terminal extens ... | 2006 | 16876823 |
| the effect of l-thyroxine supplementation in a neonatal rat model of rop. | the role of l-thyroxine in retinopathy of prematurity (rop) is controversial. recent animal studies suggest both high and low levels of serum thyroxine (exogenous supplementation and pharmacologic inhibition) are associated with preretinal neovascularization (nv) or retinal vascular retardation, a precursor of nv. to address this controversy, we studied l-thyroxine supplementation in an animal model of rop. | 2006 | 16877275 |
| energetics of aliphatic deletions in protein cores. | although core residues can sometimes be replaced by shorter ones without introducing significant changes in protein structure, the energetic consequences are typically large and destabilizing. many efforts have been devoted to understand and predict changes in stability from analysis of the environment of mutated residues, but the relationships proposed for individual proteins have often failed to describe additional data. we report here 17 apoflavodoxin large-to-small mutations that cause overa ... | 2006 | 16877708 |
| thoraco-abdominal approach to large retroperitoneal tumours. | to evaluate the thoraco-abdominal approach for resection of retroperitoneal tumours, as this approach is rarely used because, although exposure is excellent, morbidity is presumed to be increased. | 2006 | 16879442 |
| change in structure of the n-terminal region of transthyretin produces change in affinity of transthyretin to t4 and t3. | the relationship between the structure of the n-terminal sequence of transthyretin (ttr) and the binding of thyroid hormone was studied. a recombinant human ttr and two derivatives of crocodylus porosus ttrs, one with the n-terminal sequence replaced by that of human ttr (human/crocttr), the other with the n-terminal segment removed (truncated crocttr), were synthesized in pichia pastoris. subunit mass, native molecular weight, tetramer formation, cross-reactivity to ttr antibodies and binding t ... | 2006 | 16879610 |
| phase ii evaluation of gemcitabine monotherapy for cutaneous t-cell lymphoma. | the purpose of this study was to investigate safety and efficacy of gemcitabine monotherapy for cutaneous t-cell lymphoma (ctcl). | 2006 | 16879770 |
| single nucleotide polymorphisms in dna repair genes might be prognostic factors in muscle-invasive bladder cancer patients treated with chemoradiotherapy. | dna repair enzymes repair dna damaged by platinum agents and ionising radiation. single nucleotide polymorphisms (snps) in dna repair genes modulate the repair capacity and might affect response and prognosis following platinum-based chemoradiotherapy (crt). we investigated associations between the functional snps in dna repair genes and response and survival in muscle-invasive bladder cancer patients treated with crt to determine the predictive value of the snps in patient selection for bladder ... | 2006 | 16880786 |
| thyrotoxicosis in children: treatment and outcome. | to study the treatment modalities and the outcome of treatments of children with thyrotoxicosis or graves' disease. | 2006 | 16881428 |
| purification, crystallization and preliminary x-ray diffraction analysis of the phage t4 vertex protein gp24 and its mutant forms. | the study of bacteriophage t4 assembly has revealed regulatory mechanisms pertinent not only to viruses but also to macromolecular complexes. the capsid of bacteriophage t4 is composed of the major capsid protein gp23, and a minor capsid protein gp24, which is arranged as pentamers at the vertices of the capsid. in this study the t4 capsid protein gp24 and its mutant forms were overexpressed and purified to homogeneity. the overexpression from plasmid vectors of all the constructs in escherichia ... | 2006 | 16884923 |
| pharmacokinetics and pharmacotherapy of thionamides in pregnancy. | hyperthyroidism occurs in approximately 1 in every 1000 to 2000 pregnancies. although the signs and symptoms of the disease are similar in the pregnant and nonpregnant patient, the complications of hyperthyroidism can have even more profound consequences for the mother and fetus during gestation. these include maternal heart failure, preeclampsia, miscarriage, and preterm labor; as well as fetal loss and low birth weight. furthermore, thyroid function and laboratory testing for hyperthyroidism a ... | 2006 | 16885714 |
| can pacap-38 modulate immune and endocrine responses during lipopolysaccharide (lps)-induced acute inflammation? | pituitary adenylate cyclase-activating polypeptide (pacap) shows a potential anti-inflammatory activity and interacts with the endocrine system. the aim of the present article was to evaluate the effects of pacap38 on the endocrine and immune systems during acute inflammation. rats used in the experiments, divided into four groups, were given intraperitoneal injection of, respectively 0.9% nacl, lps, pacap38, and lps+pacap38. hormone (pituitary, adrenal, and thyroid) and cytokine (tnf-alpha, il- ... | 2006 | 16888158 |
| functional characterization of the 258 a/g (d2-orfa-gly3asp) human type-2 deiodinase polymorphism: a naturally occurring variant increases the enzymatic activity by removing a putative repressor site in the 5' utr of the gene. | 5' deiodination of thyroid hormone represents an important step in the modulation of the hormonal message. previous studies indicate that the naturally occurring polymorphism located in 5'-untranslated region of the gene, 258 a/g, is associated with a decrease in circulating t4/t3 ratio, suggesting an increased gene expression. the aim of this study was to characterize the gene variant in vitro. | 2006 | 16889485 |
| triiodothyronine production in graves' hyperthyroidism. | to quantify the relative contributions of thyroid secretion and peripheral generation to triiodothyronine (t(3)) production in untreated graves' hyperthyroidism. patients, design, and measurements: thirty-one patients with hyperthyroidism, of whom 6 had t(3) toxicosis, and 21 surgically and radioiodine ablated patients with thyroid cancer on thyroid stimulating hormone-suppressive therapy in whom serum t(3) should reflect peripheral generation alone were compared with respect to serum free thyro ... | 2006 | 16889493 |
| the synchronization of chemotherapy to circadian rhythms and irradiation in pre-operative chemoradiation therapy with hyperthermia for local advanced rectal cancer. | the therapeutic and adverse effects of pre-operative chrono-chemoradiation with local hyperthermia for patients with rectal adenocarcinoma were evaluated. | 2006 | 16891242 |
| [changes in hemodynamics and oxygen metabolism of different child-grade patients during orthotopic liver transplantation without veno-venous bypass]. | to investigate the changes in hemodynamics and oxygen metabolism of different child-grade patients during orthotopic liver transplantation (olt) without veno-venous bypass. | 2006 | 16892146 |
| t4 phage photoinactivation by linear furocoumarins and angular furoquinolinones. | 2006 | 16892387 | |
| sturdier dna nanotubes via ligation. | dna nanotubes are crystalline self-assemblies of dna tiles approximately 10 nm in diameter that readily grow tens of micrometers in length. easy assembly, programmability, and stiffness make them interesting for many applications, but dna nanotubes begin to melt at temperatures below 40 degrees c, break open when deposited on mica or scanned by afm, and disintegrate in deionized water. these weaknesses can be traced to the presence of discontinuities in the phosphate backbone, called nicks. the ... | 2006 | 16834415 |
| clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer. | although gleason grading may be the most useful system for evaluating biological activity of untreated prostate cancer, lack of interobserver validity with gleason scores (gs) is an unsolved issue. in this study, the proliferating cell nuclear antigen labeling index (pcna li) in untreated prostate cancer was investigated in order to clarify the usefulness of supplemental and objective markers for evaluating the biologic features of prostate cancer. | 2006 | 16834658 |
| ntp technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) (cas no. 1746-01-6) in female harlan sprague-dawley rats (gavage studies). | dioxin toxic equivalency factor evaluation overview: polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (ahr). structurally related compounds that bind to the ahr and exhibit biological actions similar to tcdd are commonly referred to as "dioxin-like compounds" (dlcs). ambient human exposure to dlcs occurs through the ingestion of foods containin ... | 2006 | 16835633 |
| ntp technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (pcb 153) (cas no. 35065-27-1) in female harlan sprague-dawley rats (gavage studies). | dioxin toxic equivalency factor evaluation overview: polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (ahr). structurally related compounds that bind to the ahr and exhibit biological actions similar to tcdd are commonly referred to as "dioxin-like compounds" (dlcs). ambient human exposure to dlcs occurs through the ingestion of foods containin ... | 2006 | 16835634 |
| lower tsh and higher t4 levels are associated with current depressive syndrome in young adults. | the relationship of individual thyroid function indices to depression in those without a history of prior thyroid dysfunction is uncertain. | 2006 | 16836601 |
| epidermal growth factor receptor as a predictor of tumor downstaging in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy. | to examine retrospectively whether levels of epidermal growth factor receptor (egfr) expression can predict tumor downstaging after preoperative chemoradiotherapy in patients with locally advanced rectal cancer. | 2006 | 16839708 |
| assembly of human immunodeficiency virus (hiv) antigens on bacteriophage t4: a novel in vitro approach to construct multicomponent hiv vaccines. | bacteriophage t4 capsid is an elongated icosahedron decorated with 155 copies of hoc, a nonessential highly antigenic outer capsid protein. one hoc monomer is present in the center of each major capsid protein (gp23*) hexon. we describe an in vitro assembly system which allows display of hiv antigens, p24-gag, nef, and an engineered gp41 c-peptide trimer, on phage t4 capsid surface through hoc-capsid interactions. in-frame fusions were constructed by splicing the human immunodeficiency virus (hi ... | 2006 | 16840347 |
| use of frozen sera for ft4 standardization: investigation by equilibrium dialysis combined with isotope dilution-mass spectrometry and immunoassay. | serum-free thyroxine (ft4) testing is recommended for diagnosis or monitoring of thyroid dysfunction, particularly in cases of hormone binding abnormalities. however, the poor intermethod agreement among commercial ft4 assays suggests a need for standardization with a hierarchically higher measurement procedure. to that purpose, we applied equilibrium dialysis (ed) in combination with isotope dilution-liquid chromatography/tandem mass spectrometry (id-lc-tandem ms). | 2006 | 16840583 |
| cell-free plasma dna as a novel marker of aseptic inflammation severity related to exercise overtraining. | circulating free plasma dna is implicated in conditions associated with tissue injury, including exercise-induced inflammation, and thus is a potential marker for athletic overtraining. | 2006 | 16840584 |
| physiological day-to-day variability of select hormones at rest in exercise-trained men. | the purpose was to determine the day-to-day variability of total testosterone (tt), total t4 (tt4), total 3,5,3'-t3 (tt3), and cortisol (c) levels in exercise-trained men [no.=63, 24+/-4 yr (x+/-sd)]. resting blood samples were collected at the same time of day (morning) over 3 consecutive days, 24 h apart, under controlled conditions. subjects were instructed to minimize mental stress and physical activity and to maintain a consistent diet, and sleep patterns during the period of blood collecti ... | 2006 | 16840824 |
| coexistence of tsh-secreting pituitary adenoma and autoimmune hypothyroidism. | tsh-secreting pituitary adenomas account for about 1-2% of all pituitary adenomas. their diagnosis may be very difficult when coexistence of other diseases masquerades the clinical and biochemical manifestations of tsh-hypersecretion. | 2006 | 16840835 |
| low t3 syndrome in psychiatric depression. | in euthyroid sick syndrome [non-thyroidal illness (nti)], a number of investigators have described tsh and serum thyroid hormone abnormalities, low t3, low t3 and t4, increased t4, low tsh, etc. those cases of nti where there is only t3 decrease [and normal serum t4, free t4 (ft4), and tsh levels] are specifically referred to as low t3 syndrome. however, the information in regard to low t3 syndrome in psychiatric subjects who are clinically euthyroid and do not have any other systemic illness is ... | 2006 | 16840838 |
| endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season. | ketosis was diagnosed in a flock of merino ewes that conceived from synchronised oestrus in the early autumn period. on day 140 of pregnancy the ewes were sampled for determination of betaoh-butyrate (bhb), ast, glucose, non-esterified fatty acids (nefa), total cholesterol (tch), insulin, t4, t3, cortisol, igf-1 and leptin. the results were evaluated according to the number of fetuses born some days later and the presence of hyperketonaemia (bhb: > or = 1.60 mmol/l). in may, about 3 months after ... | 2006 | 16841761 |
| overt and 'subclinical' hypothyroidism in women. | thyroid disease in general, and hypothyroidism in particular, are very common in women. in the usa, the most common cause of primary thyroid deficiency is on an autoimmune basis due to lymphocytic (hashimoto) thyroiditis. because there are thyroid hormone receptors in virtually every tissue of the body, the manifestations of hypothyroidism are varied, but problems with abnormal menses, conception, fertility, and pregnancy can be especially troubling in young women. the single most important diag ... | 2006 | 16842634 |
| preoperative noninvasive eus evaluation in patients with esophageal cancer considered for esophagectomy. | worldwide, esophageal cancer ranks fifth in the mortality rate regarding tumor locations. eus is an essential tool in the evaluation of these patients allowing accurate staging and permitting stratified treatment options. aim. we have studied prospectively the impact of eus in the evaluation and decision for therapy of patients with esophageal cancer diagnosed in our center. | 2006 | 16802008 |
| gingival squamous cell carcinoma: diagnostic delay or rapid invasion? | the similarity between gingival squamous cell carcinoma (gscc) and more common periodontal lesions may lead to a delay in diagnosis or misdiagnosis. neoplastic lesions of gingival tissues are frequently diagnosed at an advanced stage. | 2006 | 16805687 |
| which thyroid-stimulating hormone level should be sought in hypothyroid patients under l-thyroxine replacement therapy? | we sought to determine whether relationships exist between level of thyroid-stimulating hormone (tsh) suppression and cardiovascular risk parameters such as plasma homocysteine, c-reactive protein (crp), fibrinogen, d-dimer and serum cholesterol in patients taking l-thyroxine-replacement therapy (lt4-rt). four hundred and two hypothyroid patients under lt4-rt were cross-sectionally evaluated. patients were grouped according to their achieved tsh (miu/l) levels under lt4-rt on an arbitrary manner ... | 2006 | 16805747 |
| sensory blockade after thoracic paravertebral injection of ropivacaine or bupivacaine. | no clinical trials comparing the characteristics of sensory blockade caused by various local anaesthetics in thoracic paravertebral blockade have been published. the aim of this prospective study was a clinical assessment of sensory blockade after paravertebral injection of ropivacaine or bupivacaine in patients undergoing modified radical mastectomy. | 2006 | 16805930 |
| pacap 38 as a modulator of immune and endocrine responses during lps-induced acute inflammation in rats. | the effect of pacap 38 administration on neuroendocrine and immune parameters was examined in rats with lps-induced peritonitis. treatment with pacap 38 alone did not influence the serum level of the cytokines and hormones examined, but significantly decreased immune cell activity. when administered together with lps, pacap 38 reversed its effect on immune and humoral parameters, causing a decrease in the serum concentrations of tnfalpha and corticosterone, and an increase in t4 and gh. the majo ... | 2006 | 16806497 |
| the problem of exogenous subclinical hyperthyroidism. | over the past two decades a plethora of publications and clinical practice data have established that subclinical thyroid dysfunction is a common condition occurring much more frequently than the overt expression of thyroid disease. subclinical hypothyroidism is considered to be the most common of these entities. however, far more common and relatively less studied is exogenous sublinical hyperthyroidism (subhyper) caused by l-thyroxine (t4) administration to thyroidectomized or hypothyroid pati ... | 2006 | 16807224 |
| mechanistic coupling of bacteriophage t4 dna packaging to components of the replication-dependent late transcription machinery. | regulation of the terminal stage of viral dna development, dna packaging, is poorly understood. a new phage t4 in vitro dna packaging assay employed purified proheads, terminase (gp17 + gp16), and atp to encapsidate dna resistant to nuclease. mature phage t4 dna and linearized plasmid dnas containing or lacking a cloned t4 gene were packaged with high (approximately 10%) efficiency. supercoiled, relaxed covalently closed, and nicked circular plasmid dnas were packaged inefficiently, if at all, b ... | 2006 | 16807240 |
| the colloidal thyroxine (t4) ring as a novel biomarker of perchlorate exposure in the african clawed frog xenopus laevis. | the purpose of this study was to determine if changes in colloidal thyroxine (t(4)) immunoreactivity can be used as a biomarker of perchlorate exposure in amphibian thyroid tissue. larval african clawed frogs (xenopus laevis) were exposed to 0, 1, 8, 93, and 1131 microg perchlorate/l for 38 and 69 days to cover the normal period of larval development and metamorphosis. the results of this study confirmed the presence of an immunoreactive colloidal t(4) ring in thyroid follicles of x. laevis and ... | 2006 | 16807283 |
| correlation between protein binding strength on immobilized metal affinity chromatography and the histidine-related protein surface structure. | immobilized metal affinity chromatography (imac) was investigated for its ability to characterize the histidine-related surface structure of a protein, that is, a histidine residue's surface accessibility and its potential involvement in intramolecular interactions. t4 lysozyme was chosen as the model protein. seven amino acid sites were selected on the basis of their relative surface accessibility, and they were substituted with histidine via site-directed protein mutagenesis to generate seven ... | 2006 | 16808452 |
| genetic diversity of acanthamoeba isolated from ocean sediments. | genetic diversity of 18 acanthamoeba isolates from ocean sediments was evaluated by comparing mitochondrial (mt) dna rflp, 18s rdna sequences and by examining their cytopathic effects on human corneal epithelial cells versus reference strains. all isolates belonged to morphologic group ii. total of 16 restriction phenotypes of mtdna from 18 isolates demonstrated the genetic diversity of acanthamoeba in ocean sediments. phylogenetic analysis using 18s rdna sequences revealed that the 18 isolates ... | 2006 | 16809959 |
| locally advanced prostate cancer treated with concomitant radiation and 5-fluorouracil: southwest oncology group study 9024. | radiation is considered the standard treatment for locally advanced (t3 and t4) prostate cancer but cure with radiation alone is infrequent. studies have shown that adding androgen ablation improves the results but there is still much room for improvement. we performed a phase ii multi-institutional study to explore the feasibility of concomitant chemoradiotherapy. | 2006 | 16813886 |
| a phase ii study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer. | the aim of this study was to evaluate the efficacy and tolerance of preoperative chemoradiotherapy (crt) with irinotecan (cpt-11) and 5-fluorouracil (5-fu) in patients with resectable rectal cancer. | 2006 | 16814947 |
| the effects of age, season and geographic region on thyroid hormones in steller sea lions (eumetopias jubatus). | the purpose of this study was to investigate thyroid hormone concentrations, thyroxine (t4) and triiodothyronine (t3), in order to determine basal levels in steller sea lions of different ages and over seasons. serum concentrations of total t4 were highest in steller sea lions followed by total t3 concentrations. concentrations of free t4 and free t3 were three to four orders of magnitude lower. concentrations for all four thyroid hormone measurements tended to a lower level as animals matured b ... | 2006 | 16815718 |
| influence of daily consumption of probiotic and conventional yoghurt on the plasma lipid profile in young healthy women. | a number of studies have found conflicting results concerning the modulation of plasma lipids induced by probiotics. therefore, the aim of this study was to verify and compare the effects of probiotic and conventional yoghurt on the plasma lipid profile of normocholesterolemic women. | 2006 | 16816529 |
| [comparative study on the resistance of bacteriophage phi chi 174d, t4 and f2 to an iodophor in laboratory]. | to screen for the most resistant bacteriophage as indicator in disinfection tests, the resistance of bacteriophage phi chi 174d, t4 and f2 to iodophor were observed in laboratory. | 2006 | 16816871 |
| does endoscopic ultrasound staging already allow individual treatment regimens in gastric cancer. | the aim of our study was to evaluate the accuracy of preoperative tnm staging with endoscopic ultrasound (eus) in gastric cancer patients in comparison with the pathohistological stage of the resected specimen, and to determine the possible implications of eus for individualized treatment of gastric cancer patients at our institution. | 2006 | 16817044 |
| late toxicity in complete response cases after definitive chemoradiotherapy for esophageal squamous cell carcinoma. | we retrospectively investigated long-term toxicity after concurrent chemoradiotherapy (crt) for patients with esophageal squamous cell carcinoma (escc). | 2006 | 16799883 |
| an alternative clamp loading pathway via the t4 clamp loader gp44/62-dna complex. | in bacteriophage t4, a clamp loading pathway that utilizes the t4 clamp loader (gp44/62) and atp hydrolysis initially to form a complex with the clamp (gp45) has been demonstrated, followed by interaction with dna and closing of the clamp. however, the recent observation that gp45 exists as an opened form in solution raises the possibility of other pathways for clamp loading. in this study, an alternative clamp loading sequence is evaluated in which gp44/62 first recognizes the dna substrate and ... | 2006 | 16800623 |
| single-molecule investigation of the t4 bacteriophage dna polymerase holoenzyme: multiple pathways of holoenzyme formation. | in t4 bacteriophage, the dna polymerase holoenzyme is responsible for accurate and processive dna synthesis. the holoenzyme consists of dna polymerase gp43 and clamp protein gp45. to form a productive holoenzyme complex, clamp loader protein gp44/62 is required for the loading of gp45, along with mgatp, and also for the subsequent binding of polymerase to the loaded clamp. recently published evidence suggests that holoenzyme assembly in the t4 replisome may take place via more than one pathway [ ... | 2006 | 16800624 |
| electrostatic properties of promoter recognized by e. coli rna polymerase esigma70. | a comparative analysis of electrostatic patterns for 359 sigma70-specific promoters and 359 nonpromoter regions on electrostatic map of escherichia coli genome was carried out. it was found that dna is not a uniformly charged molecule. there are some local inhomogeneities in its electrostatic profile which correlate with promoter sequences. electrostatic patterns of promoter dnas can be specified due to the presence of some distinctive motifs which differ for different promoter groups and may be ... | 2006 | 16819795 |
| transactivation activity of thyroid hormone receptors in fish (conger myriaster) in response to thyroid hormones. | we previously isolated cdnas encoding conger eel (conger myriaster) thyroid hormone (th) receptors (trs). in the present study, we investigated the transactivation activities of conger eel trs treated with ths (3,3',5-triiodo-l-thyronine [t3], l-thyroxine [t4], and 3,3',5'-triiodo-l-thyronine [rt3]), or ligands and activators of other nuclear receptors. following transient transfection into the japanese eel (anguilla japonica) hepatocyte cell line hepa-e1, the conger eel trs (ctrs) showed th-dep ... | 2006 | 16820313 |
| [management of locally advanced prostatic adenocarcinoma in france. octave observational survey]. | to describe the management of patients with locally advanced prostate cancer in france and the changes in this management between 2000 and 2003. | 2006 | 16821343 |
| [the difference of larynx cancer stage evaluation between clinical and pathological examinations]. | comparison of stage larynx carcinoma and estimation of hazard dissemination lymph nodes in preoperative clinical and postoperative histological examination according to the tnm staging system. | 2006 | 16821535 |
| [relationship between body condition (back fat thickness and body condition scoring) and fertility in dairy cows (german black pied/hf)]. | it was the aim of this study to compare body condition scoring with ultrasonographic back fat thickness. additionally, the relationship between back fat thickness and fertility, milk yield, number of parity and stage of lactation in dairy cows was examined. body condition of 211 cows (german black pied/hf) was determined by means of ultrasonographic back fat thickness (bft) and body condition scoring (bcs). the bft and the bcs were measured at four different stages during the course of lactation ... | 2006 | 16821559 |
| local migration promotes competitive restraint in a host-pathogen 'tragedy of the commons'. | fragmented populations possess an intriguing duplicity: even if subpopulations are reliably extinction-prone, asynchrony in local extinctions and recolonizations makes global persistence possible. migration is a double-edged sword in such cases: too little migration prevents recolonization of extinct patches, whereas too much synchronizes subpopulations, raising the likelihood of global extinction. both edges of this proverbial sword have been explored by manipulating the rate of migration withi ... | 2006 | 16823452 |
| virus dna translocation: progress towards a first ascent of mount pretty difficult. | virion dna molecules of large dsdna viruses are highly condensed. to pack the dna, an atp hydrolysis-powered motor translocates the dna into a preformed empty protein shell, the prohead. the icosahedral prohead has a special fivefold vertex, the portal vertex, where the translocation machinery acts. the portal vertex contains the portal protein, a gear-shaped dodecamer of radially disposed subunits with a central channel for dna entry. the symmetry mismatch between the fivefold symmetry of the s ... | 2006 | 16824089 |
| portal fusion protein constraints on function in dna packaging of bacteriophage t4. | architecturally conserved viral portal dodecamers are central to capsid assembly and dna packaging. to examine bacteriophage t4 portal functions, we constructed, expressed and assembled portal gene 20 fusion proteins. c-terminally fused (gp20-gfp, gp20-hoc) and n-terminally fused (gfp-gp20 and hoc-gp20) portal fusion proteins assembled in vivo into active phage. phage assembled c-terminal fusion proteins were inaccessible to trypsin whereas assembled n-terminal fusions were accessible to trypsin ... | 2006 | 16824092 |
| thyrotoxicosis presenting as hypokalaemic paralysis and hyperlactataemia in an oriental man. | a 35-year-old malaysian man presented with rapid onset of flaccid quadriparesis associated with nausea and vomiting. general blood tests revealed severe hypokalaemia (serum potassium 1.5 mmol/l) and hypophosphataemia (serum phosphate 0.29 mmol/l) as a potential cause of the flaccid paralysis. arterial blood gases showed mixed acid base disturbance of respiratory alkalosis and metabolic acidosis with hyperlactataemia. thyrotoxic periodic paralysis (tpp) was suspected as the underlying cause of th ... | 2006 | 16824287 |
| role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus. | the transport of 125i-labeled thyroxine (t4) from the cerebrospinal fluid (csf) into brain and choroid plexus (cp) was measured in anesthetized rabbit [0.5 mg/kg medetomidine (domitor) and 10 mg/kg pentobarbitonal sodium (sagatal) iv] using the ventriculocisternal (v-c) perfusion technique. 125i-labeled t4 contained in artificial csf was continually perfused into the lateral ventricles for up to 4 h and recovered from the cisterna magna. the %recovery of 125i-labeled t4 from the acsf was 47.2+/- ... | 2006 | 16825415 |
| thyroid function in depression. | studies on thyroid functions were performed on patients suffering from depression. thirty four cases of depression were studied for their thyroid function and showed a diminished level of t3 and t4 with concomitant rise in tsh (thyroid stimulating hormone) level. this work showed that depressive patients had been suffering from sub-hypothyroidism. | 2006 | 16827091 |
| plasticity of the gene functions for dna replication in the t4-like phages. | we have completely sequenced and annotated the genomes of several relatives of the bacteriophage t4, including three coliphages (rb43, rb49 and rb69), three aeromonas salmonicida phages (44rr2.8t, 25 and 31) and one aeromonas hydrophila phage (aeh1). in addition, we have partially sequenced and annotated the t4-like genomes of coliphage rb16 (a close relative of rb43), a. salmonicida phage 65, acinetobacter johnsonii phage 133 and vibrio natriegens phage nt-1. each of these phage genomes exhibit ... | 2006 | 16828113 |
| monitoring activated clotting time for combined heparin and aprotinin application: in vivo evaluation of a new aprotinin-insensitive test using sonoclot. | kaolin-based activated clotting time assessed by hemochron (hkact) is a clinical standard for heparin monitoring alone and combined with aprotinin during cardiopulmonary bypass (cpb). however, aprotinin is known to prolong not only celite-based but also kaolin-based activated clotting time. overestimation of activated clotting times implies a potential hazardous risk of subtherapeutic heparin anticoagulation. recently, a novel 'aprotinin-insensitive' activated clotting time test has been develop ... | 2006 | 16828293 |
| dynamics of bacteriophage t4 presynaptic filament assembly from extrinsic fluorescence measurements of gp32-single-stranded dna interactions. | in the bacteriophage t4 homologous recombination system, presynaptic filament assembly on single-stranded (ssdna) dna requires uvsx recombinase, uvsy mediator, and gp32 ssdna-binding proteins. gp32 exerts both positive and negative effects on filament assembly: positive by denaturing ssdna secondary structure, and negative by competing with uvsx for ssdna binding sites. uvsy is believed to help uvsx displace gp32 from the ssdna. to test this model we developed a real-time fluorescence assay for ... | 2006 | 16829679 |
| recombinant human thyroid-stimulating hormone is effective for radioiodine ablation of post-surgical thyroid remnants. | to investigate whether recombinant human thyroid-stimulating factor (rhtsh) is effective for the radiometabolic ablation of post-surgery thyroid remnants, using low doses of (131)i. | 2006 | 16829763 |
| the relationship of body composition, feed intake, and metabolic hormones for broiler breeder females. | three hundred twenty cobb 500 broiler breeder pullets at 21 wk of age were selected from a flock fed according to cobb breeder management guide specifications. one hundred sixty pullets at 21 wk of age were switched to ad libitum feeding, and the remaining 160 pullets continued to be control-fed. the pullets were photostimulated at 22 wk and maintained until 36.5 wk. plasma samples were obtained, bw was determined, and hens were killed for determination of body composition at the following perio ... | 2006 | 16830857 |
| immunoexpression of multidrug-resistance protein 2 and cyclooxygenase 2 in medullary thyroid carcinomas. | chemoresistance is due to the expression of multidrug-resistance proteins (mrps). cyclooxygenase 2 (cox2), a key enzyme in prostaglandins synthesis, upregulates mrp1. mrp1 is overexpressed in medullary thyroid carcinomas (mtcs), but it is not involved in resistance to doxorubicin and cisplatin, which are commonly used in mtc treatment. mrp2 is specifically involved in resistance to both chemotherapeutic agents, but no data exist on the expression of mrp2 and cox2 in mtc. | 2006 | 16831027 |
| american society of clinical oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. | to develop a clinical practice guideline for treatment of laryngeal cancer with the intent of preserving the larynx (either the organ itself or its function). this guideline is intended for use by oncologists in the care of patients outside of clinical trials. | 2006 | 16832122 |
| [neuropsychiatric outcome in patients with congenital hypothyroidism precautiously treated: risk factors analysis in a group of patients from tuscany]. | in order to avoid an excessive medical monitoring and to obtain more functional medical controls for the outcome of children with early treated congenital hypothyroidism, the results of a neurological and psychiatric follow-up performed in area pisana since 1990 are revised. this analysis gives some indications to get over the differences of the various methodological approaches and to get better rehabilitation treatment in respect to the individual needs. | 2006 | 16832334 |