Publications

detection of autoantibodies against thyroid peroxidase in serum samples of hypothyroid dogs.	to establish a sensitive test for the detection of autoantibodies against thyroid peroxidase (tpo) in canine serum samples.	2006	16649914
juvenile hyperthyroidism: an experience.	to analyze the clinical profile of juvenile hyperthyroidism at presentation, their treatment outcome; predictors of remission and relapse.	2006	16651668
preoperative radiotherapy for locally advanced rectal cancer and prognostic factors influencing outcome.	the aim of presented study was to evaluate the impact of different factors on survival, local recurrence and development of metastatic disease in patients with rectal cancer treated with preoperative radiotherapy or 5-fluorouracil (5-fu) based concurrent chemoradiation. retrospective clinical evaluation was performed in 165 patients (33% women and 67% men) with locally advanced rectal adenocarcinoma treated with preoperative radiotherapy or chemoradiotherapy in the period january 1998 - march 20 ...	2006	16652199
characterization of the nuclear factor-kappa b responsiveness of the human dio2 gene.	type 2 iodothyronine deiodinase (d2) activates t4 by deiodination to t3, a process being the source of most t3 present in the brain. in the mediobasal hypothalamus, expression of the dio2 gene is potently activated by administration of bacterial lipopolysaccharide (lps), which in turn mediates the modifications in thyroid homeostasis typically observed in patients with nonthyroidal illness syndrome. here we show that lps-induced d2 expression is also observed in human msto-211h cells that endoge ...	2006	16728495
selective neck dissection (i-iii) for node negative and node positive necks.	selective neck dissection (i-iii) for oral cancers offers similar regional control rates with less morbidity as compared with modified radical neck dissection. charts of 414 patients with oral cancer, who underwent selective neck dissection (i-iii) during 1994-2001, were analysed retrospectively. seventy nine percent of the patients had a primary tumour in the gingivo-buccal complex. cancer of tongue showed a trend towards higher regional failure (12.3%) as compared to gingivo-buccal cancers (6. ...	2006	16730221
tissue-specific modulation of angiotensin-converting enzyme (ace) in hyperthyroidism.	we have previously demonstrated the interaction between the ras and thyroid hormones (th). the present study was designed to determine the role of th in the local regulation of ace activity and expression in different tissues. adult male wistar rats were randomized into three groups: t4-25 and t4-100 (0.025 and 0.100mg/kg of body weight/day of l-thyroxine for 14 days, respectively) and control. hemodynamic parameters as well as cardiac and renal hypertrophy were evaluated. ace activity and mrna ...	2006	16730861
induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass.	interleukin (il)-19, il-20, and il-22, three novel cytokines in the il-10 family, have recently been discovered. the biological functions and clinical implications of these cytokines are not clear. we aimed to analyze if serum levels of these cytokines were altered in inflammatory responses of postoperative cardiopulmonary bypass (cpb) and investigate the molecular mechanism involved in cytokine induction.	2006	16731153
changes in physical capacity during and after inpatient rehabilitation in subjects with a spinal cord injury.	to assess changes in physical capacity and its determinants in persons with a spinal cord injury.	2006	16731207
quantifying the healing of dry socket using a clinical volumetric method.	to quantify the healing of dry sockets using a simple clinical volumetric method that measures the reduction in the volume of dry sockets and to study the effects of sex and smoking on socket healing.	2006	16731381
diagnosis of vertebral fractures by vertebral fracture assessment.	vertebral fractures are independent risk factors for both vertebral and peripheral fractures and only one-third of these fractures come to clinical attention. vertebral fracture assessment (vfa) is a radiographic method using dual x-ray absorptiometry (dxa) to assess vertebral deformities during bone density measurement. we performed vfa of the spine from t4 to l5 on a delphi w device (hologic, bedford, ma) in 136 postmenopausal patients (69+/-10 yr). these patients also had x-rays of the thorac ...	2006	16731433
double-strand break repair in bacteriophage t4: coordination of dna ends and effects of mutations in recombinational genes.	coordination of dna ends during double-strand break (dsb) repair was studied in crosses of bacteriophage t4 in which dsbs were induced site-specifically by segc endonuclease in the dna of only one of the parents. coupling of the genetic exchanges to the left and to the right of the dsb was measured in the wild-type genetic background as well as in t4 strains bearing mutations in several recombination genes: 47, uvsx, uvsw, 59, 39 and 61. the observed quantitative correlation between the degree o ...	2006	16716767
modern management of rectal cancer: a 2006 update.	the goal of this review is to outline some of the important surgical issues surrounding the management of patients with early (t1/t2 and n0), as well as locally advanced (t3/t4 and/or n1) rectal cancer. surgery for rectal cancer continues to develop towards the ultimate goals of improved local control and overall survival, maintaining quality of life, and preserving sphincter, genitourinary, and sexual function. information concerning the depth of tumor penetration through the rectal wall, lymph ...	2006	16718838
supracricoid laryngectomies: long-term oncological and functional results.	our results confirm that supracricoid laryngectomies (sl) are reliable techniques for glottosupraglottic tumors, even for selected t3 and t4 cases, if the indications are correct. these surgical techniques allow a good quality of life with the preservation of the larynx.	2006	16720450
management of contralateral n0 neck in oral cavity squamous cell carcinoma.	the purpose of this study was to evaluate the incidence and predictive factors of contralateral occult lymph node metastasis in squamous cell carcinomas of the oral cavity to form a rational basis for elective contralateral neck management.	2006	16721743
hmg-coa reductase inhibitors (statins) might cause high elevations of creatine phosphokinase (ck) in patients with unnoticed hypothyroidism.	serious side effects of statins, including severe myopathy and rhabdomyolysis, are rare but important in general practice. hypothyroidism can cause secondary hypercholesterolemia and myopathy. there have been few reports on the risk of statins in patient with unnoticed hypothyroidism. we analyzed the characteristics of 77 patients with primary hypothyroidism in our hospital. nine patients (11%) accidentally received statins in the treatment of hypercholesterolemia without diagnosis of hypothyroi ...	2006	16723812
ductal metaplasia in chronic lymphocytic thyroiditis as a manifestation of phylogenic regression to an exocrine structure.	from a morphologic and functional point of view the thyroid can be considered as both an exocrine and endocrine organ. firstly, thyroglobulin is secreted at the apical pole of the thyrocyte. secondly, after endocytosis thyroglobulin is lysed and t3 and t4 are secreted at the basal pole into the bloodstream. however, usually exocrine glands are constituted of 2 well separate components: an acinus/alveolar component and an exocrine duct component. under particular conditions such as chronic injury ...	2006	16723858
plasma concentrations of thyroxine in dairy cows exposed to 60 hz electric and magnetic fields.	two experiments were carried out to assess the effects of electric and magnetic fields (emf) on blood thyroxine (t4) in dairy cattle. in experiment 1, 16 lactating pregnant holstein cows were exposed to 10 kv/m, 30 microtesla (microt) emf. the animals were divided into two groups of eight animals each. each group was exposed to emf according to one of two treatment sequences of three periods of 28 days each. sequence 1 was emf off-on-off and sequence 2 was emf on-off-on. during the last day of e ...	2006	16724328
sampling or node dissection for intraoperative staging of lung cancer: a multicentric cross-sectional study.	this study compares accuracy of sampling versus formal node dissection in patients with primary lung cancer.	2006	16725340
laryngeal carcinoma: five-year survival and patterns of failure in 202 consecutive patients treated with primary or post-operative radiotherapy in hong kong.	we aimed to conduct a retrospective analysis of patients treated with radiotherapy for laryngeal carcinoma at a single institution.	2006	16696880
maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat.	thyroid hormones are essential for normal functioning of adult mammalian brain. the present investigation deals with the understanding of the time course of thyroid hormone homeostasis in adult rat brain. animals were rendered hypothyroid by ptu injections (2 mg/100 g bw) for 30 consecutive days. serum and synaptosomal t3/t4 content, synaptosomal ache and na+-k+-atpase activities were determined on alternate days. while serum t4 level initially increased on the second day compared to control, se ...	2006	16698041
highly discriminatory binding of capsid-cementing proteins in bacteriophage l.	cementing proteins that bind to the virion surface have been described in double-stranded dna viruses such as herpesvirus, adenovirus, and numerous bacteriophages. the three-dimensional structure of bacteriophage l determined by electron cryo-microscopy reveals binding modes of two cementing proteins-one, called dec, encoded by phage gene orf134 and the other by an as yet unidentified gene. these two proteins form homotrimers and bind at the quasi 3-fold axes nearest the icosahedral 2-fold axes ...	2006	16698545
effects of supplementation of beta-glucans on growth performance, nutrient digestibility, and immunity in weanling pigs.	two experiments were conducted to evaluate the efficacy of beta-glucan on growth performance, nutrient digestibility, and immunity in weanling pigs. in exp. 1, 210 weanling pigs (6.38 +/- 0.92 kg of bw) were fed dietary beta-glucan (0, 0.01, 0.02, 0.03, or 0.04%) for 5 wk. in exp. 2, 168 pigs (6.18 +/- 1.31 kg of bw) were fed no beta-glucan or antibiotics (t1), 0.02% beta-glucan (t2), only antibiotics (t3), or 0.02% beta-glucan with antibiotics (t4) for 8 wk. in exp. 2, the antibiotics fed were ...	2006	16699099
a method to select for mutator dna polymerase deltas in saccharomyces cerevisiae.	proofreading dna polymerases share common short peptide motifs that bind mg(2+) in the exonuclease active center; however, hydrolysis rates are not the same for all of the enzymes, which indicates that there are functional and likely structural differences outside of the conserved residues. since structural information is available for only a few proofreading dna polymerases, we developed a genetic selection method to identify mutant alleles of the pol3 gene in saccharomyces cerevisiae, which en ...	2006	16699561
compliance and efficiency before and after implementation of a clinical practice guideline for laryngeal carcinomas.	we evaluated whether the implementation of a nationwide clinical practice guideline for diagnosis, treatment and follow-up of laryngeal carcinomas led to changes in hospital costs, balanced against clinical changes observed following the guideline's implementation. charts of 822 patients with larynx carcinoma (459 treated before the introduction of the guideline and 363 thereafter) in five hospitals were retrospectively investigated. in all phases, no differences in total hospital costs were obs ...	2006	16699832
radical prostatectomy for clinical t4 prostate cancer.	occasionally, patients with clinical t4 (ct4) prostate cancer undergo surgery. published data on outcomes after radical prostatectomy (rp) in patients with such advanced stage disease and on the impact of adjuvant radiation therapy (rt) and hormone therapy (ht) are nonexistent.	2006	16700037
expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue.	estrogen receptors (ers) are known to mediate important physiologic responses as well as the growth of some tumors in response to estradiol stimulation. in a previous study the selective er modulator raloxifene was shown to induce apoptosis in an erbeta-positive bladder cancer cell line. however, the expression of erbeta in human bladder cancer has not been thoroughly investigated.	2006	16700038
pneumomediastinum, pneumothorax and pneumoretroperitoneum following endoscopic retrieval of a tracheal foreign body from a cat.	a 6-year-old entire male cat was presented with a 1-week history of severe dyspnoea without coughing. upon auscultation, an inspiratory and particularly pronounced expiratory wheeze was noted, with severe dyspnoea. the minimum database was normal. plain thoracic radiographs showed signs of a mural or intraluminal intrathoracic (t1-t4) tracheal narrowing. a dynamic collapsing trachea was ruled out using fluoroscopy. bronchoscopy was performed and a dark green and brown spiculated foreign object w ...	2006	16700477
identification of macrolide-resistant clones of streptococcus pyogenes in portugal.	although the overall level of macrolide resistance (27%) has remained stable in portugal, a rapid inversion in the dominant phenotypes has been noted, with a sharp decrease in the mls(b) phenotype paralleled by an increase in the m phenotype. to gain further insight into these changes, 325 macrolide-resistant isolates were characterised using a combination of pulsed-field gel electrophoresis (pfge) and multilocus sequence typing (mlst). the use of cfr9i, an isoschizomer of smai, to digest m phen ...	2006	16700698
correlation of numerical aberrations of chromosomes x and 11 and poor prognosis in squamous cell carcinomas of the head and neck.	to investigate the prognostic significance of chromosomal aberrations of chromosomes x and 11 in relation to disease-specific survival in head and neck squamous cell carcinoma.	2006	16702567
pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes.	glycoprotein-hormone alpha-subunit deficient (alphasunull) mice are hypothyroid and hypogonadal due to the absence of functional tsh, lh and fsh, despite normal production of the corresponding beta subunits. pituitary tumors spontaneously developing in alphasunull mice were propagated in hypothyroid mice. the purpose of the current studies was to compare the gene expression profile of these alphasunull tumors with previously characterized ttt-97 thyrotropic tumors. a group of animals bearing eac ...	2006	16703404
functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and pituitary gland.	a major change in thyroid setpoint regulation occurs in various clinical conditions such as critical illness and psychiatric disorders. as a first step towards identifying determinants of these setpoint changes, we have studied the distribution and expression of thyroid hormone receptor (tr) isoforms, type 2 and type 3 deiodinase (d2 and d3), and the thyroid hormone transporter monocarboxylate transporter 8 (mct8) in the human hypothalamus and anterior pituitary. although the post-mortem specime ...	2006	16707210
thyroid hormone in hypopituitarism, graves' disease, congenital hypothyroidism, and maternal thyroid disease during pregnancy.	although measurement of serum thyroid-stimulating hormone (tsh) is the single best test to diagnose thyroid disorders and monitor treatment, there are certain situations in which the tsh level cannot be used as a guideline. in the diagnosis of children with hypopituitary hypothyroidism, tsh is often "inappropriately" normal. treatment is aimed at adjusting the l-thyroxine dose to maintain the serum free thyroxine (t4) in the upper half of the normal range for age. in children with graves' diseas ...	2006	16707271
tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.	mutations of the x-linked thyroid hormone (th) transporter (monocarboxylate transporter, mct8) produce in humans unusual abnormalities of thyroid function characterized by high serum t3 and low t4 and rt3. the mechanism of these changes remains obscure and raises questions regarding the regulation of intracellular availability and metabolism of th. to study the pathophysiology of mct8 deficiency, we generated mct8 knockout mice. male mice deficient in mct8 (mct8(-/y)) replicate the thyroid abnor ...	2006	16709608
molecular cloning, tissue distribution, and ontogenic thyroidal expression of the chicken thyrotropin receptor.	tsh and the interaction with its receptor (tshr) in the thyroid gland play a crucial role in the pituitary-thyroid axis of all vertebrates. released upon stimulation by tsh, thyroid hormones influence numerous processes in the body and are extremely important during the last week of chicken embryonic development. in this study, we have cloned and functionally characterized the chicken tshr (ctshr), which was found to be a g protein-coupled receptor consisting of 10 exons. besides the full-length ...	2006	16709612
iron deficiency in goitrous schoolchildren of semirom, iran.	iodine deficiency produces the spectrum of iodine deficiency disorders (idds): endemic goiter, hypothyroidism, cretinism, and congenital anomalies. other factors, including goitrogens and micronutrient deficiencies, may influence the prevalence and severity of idds and response to iodine supplementation. this cross-sectional, descriptive study was performed in 2003 on elementary school children of semirom, a mountainous region of iran, where goiter was hyper-endemic in 1994, but the goiter preva ...	2006	16710096
[change in location of colorectal cancer in hungarian patients between 1993-2004].	the incidence of proximal tumours in western countries has steadily increased while that of distal tumours has shown a corresponding decrease. our aim was to investigate the prevalence, location and histology of colorectal cancers in the last twelve years in hungarian patients.	2006	16711260
cell typing of the scabetic lesion and its clinical correlation.	scabies is a pruritic dermatosis due to infestation by a mite that stimulates both humoral and cellular immune responses causing cutaneous lesions as well as pruritus. changes in immune response pattern with treatment are associated with improvement in symptoms and clinical cure. in this study, we analysed the cellular infiltrate types and patterns in lesions of scabies. treated patients were divided into 2 groups as those with and without pruritus. in the pre-treatment cases, there was a high i ...	2006	16711537
chemoprevention of nonmelanoma skin cancer.	skin cancer is the most common cancer in human beings. the increased incidence of skin cancer has brought much attention to the process by which these tumors develop and how they can be prevented. efforts have been made to educate the public about the importance of protecting skin from excessive ultraviolet light. despite this work, the incidence of skin cancer continues to increase. available compounds may be useful in the chemoprevention of skin cancer. chemoprevention is defined as oral or to ...	2006	16713450
prognostic predictors of squamous cell carcinoma of the buccal mucosa with negative surgical margins.	to study the prognostic factors of squamous cell carcinoma of the buccal mucosa (bmscc) with negative surgical margins.	2006	16713803
involvement of thyroxine in ovarian toxicity of di-(2-ethylhexyl) phthalate.	forced ovulation induced by the administration of exogenous gonadotropin is a useful marker for studying the ovarian toxicity of chemicals in experimental animals. we examined the toxicity of di-(2-ethylhexyl) phthalate (dehp) in the ovaries of immature f344 female rats. superovulation was induced by injections of equine chorionic gonadotropin (ecg) and human chorionic gonadotropin (hcg) in rats dosed with 125, 250, 500, 1,000 or 2,000 mg/kg body weight of dehp for 4 consecutive days. the number ...	2006	16716002
genetic diversity among five t4-like bacteriophages.	bacteriophages are an important repository of genetic diversity. as one of the major constituents of terrestrial biomass, they exert profound effects on the earth's ecology and microbial evolution by mediating horizontal gene transfer between bacteria and controlling their growth. only limited genomic sequence data are currently available for phages but even this reveals an overwhelming diversity in their gene sequences and genomes. the contribution of the t4-like phages to this overall phage di ...	2006	16716236
prognostic factors of anaplastic thyroid carcinoma.	anaplastic thyroid carcinoma (atc) is one of the most aggressive malignancies. we tried to elucidate the possible prognostic factors.	2006	16553028
acute changes in clinical parameters and thyroid function peripheral markers following l-t4 withdrawal in patients totally thyroidectomized for thyroid cancer.	after total thyroidectomy, differentiated thyroid cancer (dtc) patients have to undergo l-t4 withdrawal for measuring serum thyroglobulin and 131i whole-body scan (131i wbs) to evaluate residual/recurrent malignant disease. the aim of the present work was to study in these patients the effects of acute thyroid hormone deficiency on various target organs and tissues. clinical parameters and thyroid function peripheral markers were evaluated in 20 dtc patients, both before and after l-t4 withdrawa ...	2006	16553031
predictors of anxiety and depression following pregnancy termination: a longitudinal five-year follow-up study.	the aims of the study were to assess anxiety and depression in women who had experienced either a miscarriage or an induced abortion, to compare the women's level of distress with that of a general population sample, and to find predictors of anxiety and depression six months and five years after the event.	2006	16553180
evolution of bacteriophage tails: structure of t4 gene product 10.	the success of tailed bacteriophages to infect cells far exceeds that of most other viruses on account of their specialized tail and associated baseplate structures. the baseplate protein gene product (gp) 10 of bacteriophage t4, whose structure was determined to 1.2 a resolution, was fitted into the cryo-electron microscopy structures of the pre and post-infection conformations of the virus. gp10 functions as a molecular lever that rotates and extends the hinged short tail fibers to facilitate ...	2006	16554069
radical radiotherapy for bladder cancer: retrospective analysis of a series of 459 patients treated in an italian institution.	to contribute to the available evidence about the efficacy of exclusive radiotherapy for bladder cancer through a retrospective analysis of a large series of patients consecutively treated in a single institution.	2006	16477920
biosensor recognition of thyroid-disrupting chemicals using transport proteins.	novel surface plasmon resonance-based biosensor assays for the bioeffect-related screening of chemicals with thyroid-disrupting activity are described. two thyroid transport proteins (tps), thyroxine binding globulin (tbg) and recombinant transthyretin (rttr), were applied in an inhibition assay format in a biacore 3000 using cm5 biosensor chips coated with l-thyroxine (t4), the main hormone of the thyroid system. assay conditions were optimized for the natural thyroid hormones, and known thyroi ...	2006	16478101
differential effects of experimental and cold-induced hyperthyroidism on factors inducing rat liver oxidative damage.	thyroid hormone-induced increase in metabolic rates is often associated with increased oxidative stress. the aim of the present study was to investigate the contribution of iodothyronines to liver oxidative stress in the functional hyperthyroidism elicited by cold, using as models cold-exposed and 3,5,3'-triiodothyronine (t3)- or thyroxine (t4)-treated rats. the hyperthyroid state was always associated with increases in both oxidative capacity and oxidative damage of the tissue. the most extensi ...	2006	16481571
pharyngo-esophageal reconstruction using pectoralis major cutaneous muscular flap after total laryngopharyngectomy.	using the pectoralis major myocutaneous flap is a good opportunity for one-stage reconstruction of the removed hypopharynx after total laryngopharyngectomy. the authors share their experience with five patients who underwent this kind of operation for t4 cancer of the hypopharynx and discuss their results.	2006	16482458
clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism.	thirteen cats, newly diagnosed with hyperthyroidism, were treated with a transdermal formulation of methimazole at a dose of 5 mg (0.1 ml) (concentration of 50 mg/ml) applied to the internal ear pinna every 12 h for 28 d. baseline hematologic and biochemical values, along with serum thyroxine (t4) levels, were obtained on presentation (day 0). cats were evaluated at 14 d (d14) and 28 d (d28) following transdermal therapy. at each visit, a physical examination, a complete blood cell count, a seru ...	2006	16579038
effects of deracoxib and aspirin on serum concentrations of thyroxine, 3,5,3'-triiodothyronine, free thyroxine, and thyroid-stimulating hormone in healthy dogs.	to evaluate the effects of deracoxib and aspirin on serum concentrations of thyroxine (t4), 3,5,3'-triiodothyronine (t3), free thyroxine (ft4), and thyroid-stimulating hormone (tsh) in healthy dogs.	2006	16579752
addison's disease presenting as male infertility.	to present a case of primary male infertility with severe oligospermia and hyperpigmented skin as the main presenting clinical signs.	2006	16580396
thyroid hormone receptor alpha1 directly controls transcription of the beta-catenin gene in intestinal epithelial cells.	thyroid hormones, t3 and t4, are known regulators of intestine development. the best characterized example is the remodeling of the gastrointestinal tract during amphibian metamorphosis. thyroid hormones act via nuclear receptors, the trs, which are t3-dependent transcription factors. we previously showed that intestinal epithelial cell proliferation is controlled by thyroid hormones and the tralpha gene. to analyze the mechanisms responsible, we studied the expression of genes belonging to and/ ...	2006	16581794
reflex regulation of airway sympathetic nerves in guinea-pigs.	sympathetic nerves innervate the airways of most species but their reflex regulation has been essentially unstudied. here we demonstrate sympathetic nerve-mediated reflex relaxation of airway smooth muscle measured in situ in the guinea-pig trachea. retrograde tracing, immunohistochemistry and electrophysiological analysis identified a population of substance p-containing capsaicin-sensitive spinal afferent neurones in the upper thoracic (t1-t4) dorsal root ganglia (drg) that innervate the airwa ...	2006	16581869
distance determination by giy-yig intron endonucleases: discrimination between repression and cleavage functions.	giy-yig homing endonucleases are modular proteins, with conserved n-terminal catalytic domains connected by linkers to c-terminal dna-binding domains. i-tevi, the t4 phage giy-yig intron endonuclease, functions both in promoting td intron homing, and in acting as a transcriptional autorepressor. repression is achieved by binding to an operator, which is cleaved at 100-fold reduced efficiency relative to the intronless homing site. the linker includes a zinc finger, which functions in distance de ...	2006	16582101
single-stage thoracolumbar vertebrectomy with circumferential reconstruction and arthrodesis: surgical technique and results in 15 patients.	circumferential reconstruction and arthrodesis can be necessary after thoracolumbar vertebrectomy. the authors describe a technique for single-stage thoracolumbar vertebrectomy with circumferential reconstruction and arthrodesis. the surgical results using this technique are reviewed.	2006	16582649
increased transglutaminase activity was associated with il-6 release in cultured human gingival fibroblasts exposed to dental cast alloys.	molecular mechanisms underlying gingival and periodontal inflammation caused by dental alloys are still poorly understood. recently, it has been demonstrated that tissue transglutaminase can be involved in inflammatory cell response. the aim of this study was to evaluate effects of exposure to orthodontic materials on transglutaminase in cultured human gingival fibroblasts. the incubation with ni-ti heat-activated (t3) or ni-ti super-elastic (t4), and with ni-cr-co (t2) alloys produced respectiv ...	2006	16583305
[ambivalent bacteriophages of different species active on escherichia coli k12 and salmonella sps. strains].	a study was made of several bacteriophages (including phages u2 and lb related to t-even phages of escherichia coli) that grow both on e. coli k12 and on some salmonella strains. such phages were termed ambivalent. t-even ambivalent phages (u2 and lb) are rare and have a limited number of hosts among salmonella strains. u2 and lb are similar to canonical e. coli-specific t-even phages in morphological type and size of the phage particle and in reaction with specific anti-t4 serum. phages u2 and ...	2006	16583699
hyperthyroidism and the kidney.	hyperthyroidism and chronic renal failure (crf) are both common diseases of older cats. hyperthyroidism increases gfr by a variety of physiologic effects. chronic renal failure can suppress total t4 concentrations in cats with concurrent hyperthyroidism, and free t4 is not a useful distinguishing test. medical therapy (ie, methimazole) is recommended in cats with pre-existing crf. overt renal failure occurs in approximately 30% of cats treated for hyperthyroidism. it usually occurs within one mo ...	2006	16584026
medical management of hyperthyroidism.	radioiodine is considered the treatment of choice for hyperthyroidism, but in some situations, methimazole therapy is preferred, such as in cats with pre-existing renal insufficiency. methimazole blocks thyroid hormone synthesis, and controls hyperthyroidism in more than 90% of cats that tolerate the drug. unfavorable outcomes are usually due to side effects such as gastrointestinal (gi) upset, facial excoriation, thrombocytopenia, neutropenia, or liver enzyme elevations; warfarin-like coagulopa ...	2006	16584027
a bioluminescence assay for thyrotropin receptor antibodies predicts serum thyroid hormone levels in patients with de novo graves' disease.	tsh receptor antibodies (tbii) in graves' disease (gd) may be tsh receptor stimulating (tsab) and blocking (tbab) antibodies. in commercially available assays however, only total tbii titres can be measured, without discriminating between tsab and tbab.	2006	16584516
[endonasal micro-endoscopic resection of sinonasal inverted papilloma].	the goal of this study was to assess the potentials and limitations of endonasal micro-endoscopic surgery in the treatment of sinonasal inverted papilloma (ip) and to demonstrate long-term results.	2006	16586283
prevalence of autoantibodies associated with thyroid and celiac disease in ullrich-turner syndrome in relation to adult height after growth hormone treatment.	a prospective, multicenter study of patients with ullrich-turner syndrome (uts) was conducted to estimate the prevalence of autoantibodies to tissue transglutaminase (ttg), thyroid stimulating hormone receptor (tsh-r), thyroglobulin (tg) and thyroid peroxidase (tpo) in relation to adult height after long-term growth hormone (gh) treatment. out of 347 near-adult (> 16 years) patients with uts from 96 german centers, whose longitudinal growth was documented within the pharmacia international growt ...	2006	16562588
[effects of different doses of fentanyl on the stress response in patients undergoing valve replacement].	to investigate the effects of different doses of fentanyl on the stress response in valve replacement surgery during cardiopulmonary bypass (cpb).	2006	16562684
four year clinical statistics of iridium-192 high dose rate brachytherapy.	we evaluated the efficacy and complications of high dose rate (hdr) brachytherapy using iridium-192 (192ir) combined with external beam radiotherapy (ebrt) in patients with prostate cancer.	2006	16563134
associations of organochlorines with endogenous hormones in male great lakes fish consumers and nonconsumers.	this study investigated the relationships of steroid and thyroid hormones with total noncoplanar polychlorinated biphenyls (pcbs), total toxic equivalents (teqs) from dioxins-like organochlorines, and dichlorodiphenyl dichloroethene (dde) in 56 male frequent and infrequent great lakes sport caught fish consumers. significant negative associations were found for triiodothyronine (t3), thyroxine (t4), thyroid stimulating hormone (tsh), and sex hormone binding globulin (shbg)-bound testosterone wit ...	2006	16563369
one-year follow-up after thoracoscopic sympathectomy for hyperhidrosis: outcomes and consequences.	thoracic sympathectomy is recognized as an effective treatment for patients with severe hyperhidrosis. while good early results have been documented, continuing efficacy and patient satisfaction has not been well-defined. we reviewed our results in patients who were at least one year out from surgery.	2006	16564248
prognostic significance of microvessel density and vascular endothelial growth factor expression in sinonasal carcinomas.	the prognostic significance of microvessel density and proliferative activity of the neoplastic cells, evaluated respectively by cd31 and ki-67 positivity, and immunohistochemical expression of vascular endothelial growth factor (vegf) was retrospectively investigated in 105 cases of sinonasal carcinoma (80 surgical specimens and 25 biopsies). the most represented histologic types were intestinal-type adenocarcinoma found in 36 patients (34.3%), squamous cell carcinoma (scc) in 34 (32.4%), mucin ...	2006	16564912
multiple olfactory receptor neurons and their axonal projections in the antennal lobe of the honeybee apis mellifera.	the poreplate sensilla of honeybees are equipped with multiple olfactory receptor neurons (orns), which innervate glomeruli of the antennal lobe (al). we investigated the axonal projection pattern in glomeruli of the al (glomerular pattern), formed by the multiple orns of individual poreplate sensilla. we used the different glomerular patterns to draw conclusions about the equipment of poreplate sensilla with different orn types. orns of single poreplate sensilla were stained and analyzed by las ...	2006	16566001
peritoneal cytology does not increase the prognostic information provided by tnm in gastric cancer.	this study aimed at verifying whether peritoneal cytology could improve the prognostic information provided by tnm staging in gastric cancer patients.	2006	16568221
thyroid hormone and thyrotropin regulate intracellular free calcium concentrations in human polymorphonuclear leukocytes: in vivo and in vitro studies.	intracellular free calcium concentrations (ca++i) were studied in polymorphonuclear leukocytes (pmns) from 13 athyreotic patients who had been previously treated by total thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma, and from age- and sex-matched euthyroid healthy controls. patients were studied twice, when hypothyroid (visit 1) and after restoration of euthyroidism by l-t4 tsh-suppressive therapy (visit 2). pmns from patients at visit 1 had significantly lower rest ...	2006	16569353
effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on the pituitary-thyroid-axis.	the lack of estrogen during menopause is associated with various symptoms including osteoporosis, cardiovascular diseases, and menopausal symptoms. for many years, conventional hormone replacement therapy has been successfully used to treat these conditions. however, in light of recent studies that draw attention to potential hazards of conventional hrt, various attempts were undertaken to search for alternatives of classical hrt. phytoestrogens are supposed to ameliorate various discomforts ass ...	2006	16570238
development of effective quantum mechanical/molecular mechanical (qm/mm) methods for complex biological processes.	motivated by the long-term goal of understanding vectorial biological processes such as proton transport (pt) in biomolecular ion pumps, a number of developments were made to establish combined quantum mechanical/molecular mechanical (qm/mm) methods suitable for studying chemical reactions involving significant charge separation in the condensed phase. these developments were summarized and discussed with representative problems. specifically, free energy perturbation and boundary potential meth ...	2006	16570942
the effect of visual biofeedback on the propulsion effectiveness of experienced wheelchair users.	to determine the effect of visual feedback on the propulsion effectiveness of experienced manual wheelchair users.	2006	16571390
methods to electrophoretically stretch dna: microcontractions, gels, and hybrid gel-microcontraction devices.	the ability to controllably and continuously stretch large dna molecules in a microfluidic format is important for gene mapping technologies such as direct linear analysis (dla). we have recently shown that electric field gradients can be readily generated in a microfluidic device and the resulting field is purely elongational. we present a single molecule fluorescence microscopy analysis of t4 dna (169 kbp) stretching in the electric field gradients in a hyperbolic contraction microchannel. in ...	2006	16572214
arm to leg coordination in elite butterfly swimmers.	this study proposed the use of four time gaps to assess arm-to-leg coordination in the butterfly stroke at increasing race paces. fourteen elite male swimmers swam at four velocities corresponding to the appropriate paces for, respectively, the 400-m, 200-m, 100-m, and 50-m events. the different stroke phases of the arm and leg were identified by video analysis and then used to calculate four time gaps (t1: time gap between entry of the hands in the water and the high break-even point of the fir ...	2006	16572376
the impact of hypotension due to the trigeminocardiac reflex on auditory function in vestibular schwannoma surgery.	surgical manipulation of the fifth cranial nerve during its intra- or extracranial course may lead to bradycardia or even asystole as well as arterial hypotension, a phenomenon described as the trigeminocardiac reflex (tcr). the authors studied the impact of this reflex on postoperative auditory function in patients undergoing vestibular schwannoma (vs) surgery.	2006	16572648
a role for replication repair in the genesis of templated mutations.	replication repair mediates error-free bypass of dna damage in a series of steps that include regression of the replication fork, primer-terminus switching to use the other daughter strand as an undamaged template, primer extension, primer switching back to its cognate template with the primer terminus now having bypassed the damage, and fork rearrangement to a normal configuration. by both genetic and biochemical criteria, bacteriophage t4 catalyzes replication repair with two alternative sets ...	2006	16574154
targeted thoracic epidural blood patch placed under electrical stimulation guidance (tsui test).	this case report describes the use of electrical epidural stimulation (tsui test) to confirm accurate placement of a thoracic epidural catheter when administering an epidural blood patch for headache management in a patient suffering from spontaneous intracranial hypotension.	2006	16575036
morphometric analysis of mandibular growth in skeletal class iii malocclusion.	the craniofacial growth patterns of untreated individuals with skeletal class iii malocclusion have rarely been systemically investigated. this study used morphometric techniques to investigate the growth characteristics of the mandible in individuals with skeletal class iii malocclusion.	2006	16618612
efficient rna 5'-adenylation by t4 dna ligase to facilitate practical applications.	we describe a simple procedure for rna 5'-adenylation using t4 dna ligase. the 5'-monophosphorylated terminus of an rna substrate is annealed to a complementary dna strand that has a 3'-overhang of 10 nucleotides. then, t4 dna ligase and atp are used to synthesize 5'-adenylated rna (5'-apprna), which should find use in a variety of practical applications. in the absence of an acceptor nucleic acid strand, the two-step t4 dna ligase mechanism is successfully interrupted after the adenylation step ...	2006	16618967
[comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].	to scan the most resistable bacteriophage as an indicator in disinfection tests, and to study the resistance of bacteriophage t4, phichi 174d, and f2 to the sodium dichloroisocyanurate (nadcc) in laboratory.	2006	16620594
neoadjuvant chemotherapy for locally advanced carcinoma of the lower oesophagus and oesophago-gastric junction.	to evaluate a single unit's experience with neoadjuvant chemotherapy for treating locally advanced non-metastatic initially resectable and unresectable oesophago-gastric cancer.	2006	16621430
advantages and pitfalls of 18f-fluoro-2-deoxy-d-glucose positron emission tomography in detecting locally residual or recurrent nasopharyngeal carcinoma: comparison with magnetic resonance imaging.	this prospective study was designed to elucidate the advantages and pitfalls of (18)f-fdg pet in detecting locally residual/recurrent nasopharyngeal carcinoma (npc) in comparison with mri.	2006	16622711
population-based study of prognostic factors in stage ii colonic cancer.	adjuvant chemotherapy in stage ii colorectal cancer may be considered for patients whose tumours have poor prognostic features. the aim of this study was to evaluate the prognostic significance of commonly reported clinical and pathological features of stage ii colonic cancer.	2006	16622901
prostate cancer screening and detection in inner-city and underserved men.	in the era of serum prostate-specific antigen (psa) screening, the incidence of prostate cancer has increased dramatically. simultaneously however, stage migration has occurred, and treatment outcomes have improved. inner-city men have lower screening rates and, thus, may be diagnosed with more advanced disease that it less likely to be successfully treated.	2006	16623063
evaluation of the longitudinal contraction of the ventricle septum in patients undergoing off-pump coronary artery bypass graft surgery by strain rate imaging.	strain rate (sr) imaging is an emerging technique for assessing myocardial systolic and diastolic functions. this technique can provide assessment in real time and color mapping; it also can detect ischemia at its earlier stages in comparison with visual estimation of wall motion with other techniques.	2006	16623402
procalcitonin and conventional markers of inflammation in peritoneal dialysis patients and peritonitis.	to determine the significance of a newly described marker of inflammation procalcitonin (pct), and to investigate its relationship to conventional markers of inflammation, such as c-reactive protein (crp), fibrinogen, and erythrocyte sedimentation rate (esr), in patients on peritoneal dialysis (pd) and with peritonitis.	2006	16623432
transcription of a 'photosynthetic' t4-type phage during infection of a marine cyanobacterium.	the transcription of s-pm2 phage following infection of synechococcus sp. wh7803, a marine cyanobacterium, was analysed by quantitative real-time pcr. unlike the distantly related coliphage t4, there were only two (early and late) instead of three (early, middle and late) classes of transcripts during the developmental cycle of the phage. this difference is consistent with the absence from the s-pm2 genome of t4-like middle mode promoter sequences and the transcription factors associated with th ...	2006	16623740
subclinical thyroid disorders and cognitive performance among adolescents in the united states.	thyroid hormone plays a crucial role in the growth and function of the central nervous system. the purpose of the study was to examine the relationships between the status of subclinical thyroid conditions and cognition among adolescents in the united states.	2006	16623938
relationship between subclinical thyroid dysfunction and femoral neck bone mineral density in women.	osteoporosis associated with thyroid dysfunction has been traditionally viewed as a secondary consequence of altered thyroid function, but there was recently a report about the direct effects of thyroid-stimulating hormone (tsh) on bone remodeling, which was mediated via the tsh receptor found on osteoblast and osteoclast precursor cells. endogenous subclinical thyroid dysfunction seems to be an appropriate model to examine the direct effect of tsh on bone metabolism while ruling out the direct ...	2006	16624651
[effect of oral cordarone in reversing persistent atrial fibrillation].	to observe the efficacy and safety of oral cordarone dir reversing persistent atrial fibrillation (af). methods; eighty-two symptomatic chronic af out-patients without history of acute diseases or severe hepatic/thyroid dysfunction were given oral cordarone at the loading dose of 200 mg thrice a day for 1-4 weeks followed by a twice-daily administration for another 1-4 weeks, with the maintenance dose of 200 or 100 mg once a day. the incidence of stroke and cardiac events and the mortality rate ...	2006	16624772
synchronous primary carcinomas of the bladder and prostate.	to determine the incidence of adenocarcinoma of the prostate for patients undergoing radical cystoprostatectomy for bladder cancer in taiwan.	2006	16625287
a mode of action for induction of thyroid gland tumors by pyrethrins in the rat.	prolonged treatment with high doses of pyrethrins results in thyroid gland tumors in the rat. to elucidate the mode of action for tumor formation, the effect of pyrethrins on rat thyroid gland, thyroid hormone levels and hepatic thyroxine udpglucuronosyltransferase activity was investigated. male sprague-dawley cd rats were fed diets containing 0 (control) and 8000 ppm pyrethrins and female rats diets containing 0, 100, 3000 and 8000 ppm pyrethrins for periods of 7, 14 and 42 days and for 42 day ...	2006	16626768
staging of nasopharyngeal carcinoma investigated by magnetic resonance imaging.	to investigate the american joint commission on cancer (ajcc) sixth edition staging system of nasopharyngeal carcinoma (npc) by magnetic resonance imaging (mri).	2006	16626827
dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the hong kong nasopharyngeal carcinoma study group (hknpcsg).	to define the dose-response relationship of nasopharyngeal carcinoma (npc) above the conventional tumoricidal dose level of 66 gy when the basic radiotherapy (rt) course was given by the 2d ho's technique.	2006	16626829
placental restriction alters circulating thyroid hormone in the young lamb postnatally.	intrauterine growth restriction (iugr) is associated with accelerated growth and increased adiposity in early life due to unknown mechanisms, which could include increased thyroid hormone (th) action. we hypothesized that placental restriction (pr) of fetal growth would increase circulating th concentrations and alter their response to fasting, and that these would relate to growth and body composition in the young lamb. pr reduced size at birth, increased fractional growth rates (fgrs) of soft ...	2006	16627695
ntp toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (pcb 126) (cas no. 57465-28-8) in female harlan sprague-dawley rats (gavage studies).	dioxin toxic equivalency factor evaluation overview: polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (ahr). structurally related compounds that bind to the ahr and exhibit biological actions similar to tcdd are commonly referred to as "dioxin-like compounds" (dlcs). ambient human exposure to dlcs occurs through the ingestion of foods containin ...	2006	16628245
managing thyroid cancer without thyroxine withdrawal.	thyroxine (t4) withdrawal or recombinant tsh is used for the stimulation of thyroglobulin (tg), whole-body scanning (wbs) and iodine-131 treatment in patients with thyroid carcinoma. this study evaluated the t4 dose reduction protocol as an alternative for patients' preparation. fifty-one patients were submitted to total t4 withdrawal for wbs and tg measurement. t4 treatment was then resumed and maintained until tsh reached levels < 0.3 miu/l. the t4 dose was then decreased to 0.8 microg/kg/day ...	2006	16628280
rhizosphere bacteria affected by transgenic potatoes with antibacterial activities compared with the effects of soil, wild-type potatoes, vegetation stage and pathogen exposure.	a greenhouse experiment was performed to analyze a potential effect of genetically modified potatoes expressing antibacterial compounds (attacin/cecropin, t4 lysozyme) and their nearly isogenic, nontransformed parental wild types on rhizosphere bacterial communities. to compare plant transformation-related variations with commonly accepted impacts caused by altered environmental conditions, potatoes were cultivated under different environmental conditions, for example using contrasting soil type ...	2006	16629752