Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| detection of a serine proteinase gene in acanthamoeba genotype t6 (amoebozoa: lobosea). | cytopathic proteins are assumed to contribute to the pathogenicity of acanthamoeba spp. due to their degrading capacity that is required for tissue invasion. in this study, a serine proteinase gene was demonstrated in a highly virulent acanthamoeba keratitis causing strain with genotype t6. this gene was detected in both, the genomic dna and the cdna by pcr and subsequent sequencing. the gene fragment comprises about 500 bp and exhibits high sequence similarity to the serine proteinases of acant ... | 2006 | 16545805 |
| both regions 4.1 and 4.2 of e. coli sigma(70) are together required for binding to bacteriophage t4 asia in vivo. | the t4 asia is an anti-sigma factor encoded by one of the early genes of bacteriophage t4. it has been shown that asia inhibits transcription from promoters containing -10 and -35 consensus sequence by binding to sigma(70) of e. coli. binding of asia to sigma(70) in vivo, in e. coli, leads to inhibition of transcription of essential genes resulting in killing of the organism. by using various in vitro methods, the region of sigma(70) binding to asia have been mapped to domain 4.2. additionally, ... | 2006 | 16545925 |
| influences of isotonic, hypertonic and hypovolemic treatments on vasopressin response and fluid-electrolyte balance in l-thyroxine-induced hyperthyroid rat. | the present study was performed to determine how l-thyroxine-induced hyperthyroidism affects the vasopressin response to different stimulations (isotonic, hypertonic and hypovolemic) in rats. spraque-dawley rats were initially separated into 3 groups; control (n=24), sham hyperthyroidism (n=24, hyperthyroidism (n=24). at the end of the experiment additional sub-groups were formed before decapitation. these sub-groups were formed as; without stimulation (n=6), isotonic stimulation (n=6), hyperton ... | 2006 | 16546217 |
| synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease iii reaction. | endonuclease iii (endo iii) is a base excision repair enzyme that recognizes oxidized pyrimidine bases including thymine glycol. this enzyme is a glycosylase/lyase and forms a schiff base-type intermediate with the substrate after the damaged base is removed. to investigate the mechanism of its substrate recognition by x-ray crystallography, we have synthesized oligonucleotides containing 2'-fluorothymidine glycol, expecting that the electron-withdrawing fluorine atom at the 2' position would st ... | 2006 | 16547199 |
| diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms. | approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (fna) biopsy results. because their risk of cancer is approximately 20%, these patients undergo thyroidectomy. we hypothesized that genes that regulate cell-cycle progression would be differentially expressed in malignant versus benign thyroid nodules and could serve as diagnostic markers and markers of disease aggressiveness. | 2006 | 16547620 |
| persistence of genetic variants of the arctic fox strain of rabies virus in southern ontario. | genetic-variant analysis of rabies viruses provides the most sensitive epidemiologic tool for following the spread and persistence of these viruses in their wildlife hosts. since its introduction by a southern epizootic movement that began in the far north, the arctic fox (afx) strain of rabies virus has been enzootic in ontario for almost 50 y. prior genetic studies identified 4 principal genetic variants (ont.t1 to ont.t4) that were localized to different regions of the province; furthermore, ... | 2006 | 16548327 |
| an expanded protein folding cage in the groel-gp31 complex. | bacteriophage t4 produces a groes analogue, gp31, which cooperates with the escherichia coli groel to fold its major coat protein gp23. we have used cryo-electron microscopy and image processing to obtain three-dimensional structures of the e.coli chaperonin groel complexed with gp31, in the presence of both atp and adp. the groel-gp31-adp map has a resolution of 8.2 a, which allows accurate fitting of the groel and gp31 crystal structures. comparison of this fitted structure with that of the gr ... | 2006 | 16549073 |
| futility of fluorodeoxyglucose f 18 positron emission tomography in initial evaluation of patients with t2 to t4 melanoma. | evaluation of newly diagnosed patients with melanoma for metastasis is requisite to treatment planning. the reported diagnostic yield of whole-body conventional radiological imaging in initial staging of patients with melanoma is low. however, the diagnostic yield of positron emission tomography (pet) for distant metastases is unclear. | 2006 | 16549694 |
| factors affecting the prognosis of patients with esophageal cancer undergoing salvage surgery after definitive chemoradiotherapy. | although salvage surgery after definitive chemoradiotherapy (crt) is common, the safety and indication has not yet been established. | 2006 | 16550581 |
| the effects of amino acid supplementation on hormonal responses to resistance training overreaching. | the purpose of this investigation was to examine the effects of amino acid supplementation on muscular performance and resting hormone concentrations during resistance training overreaching. seventeen resistance-trained men were randomly assigned to either an amino acid (aa) or a placebo (p) group and underwent 4 weeks of total-body resistance training designed to induce a state of overreaching. the protocol consisted of two 2-week phases (phase 1, 3 sets of 8 exercises performed for 8-12 repeti ... | 2006 | 16483870 |
| comparison of epileptic and nonepileptic cases with centrotemporal spikes in view of clinical findings and electroencephalographic characteristics. | the morphological features of centrotemporal spike discharges (ctsd) and relationship of them with clinical diagnosis in cases with benign epilepsy of childhood with centrotemporal spikes (bects) and the other epileptic syndromes of childhood as well as some nonconvulsive neurological disorders were detected in the routine patient population who referred to the authors' eeg laboratory. thirty-six cases (21 males, 15 females; 8 months-14 years old), in which awake and/or sleep eegs revealed ctsd ... | 2006 | 16484056 |
| surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. | goblet cell carcinoid (gcc) is a rare malignant tumor with distinct histological and clinical features. our goals were to review the surgical and chemotherapy outcomes of patients with gcc. | 2006 | 16485156 |
| the molecular solid sc24c10i30: a truncated, hollow t4 supertetrahedron of iodine filled with a t3 supertetrahedron of scandium that encapsulates the adamantoid cluster sc4c10. | 2006 | 16485307 | |
| elasticity theory for self-assembled protein lattices with application to the martensitic phase transition in bacteriophage t4 tail sheath. | we propose an elasticity theory for one- and two-dimensional arrays of globular proteins for which the free energy is affected by relative position and relative rotation between neighboring molecules. the kinematics of such assemblies is described, the conditions of compatibility are found, a form of the free energy is given, and formulas for applied forces and moments are developed. it is shown that fully relaxed states of sheets consist of helically deformed sheets which themselves are compose ... | 2006 | 16486195 |
| thyroid hormone deiodination in birds. | because the avian thyroid gland secretes almost exclusively thyroxine (t4), the availability of receptor-active 3,3',5-triiodothyronine (t3) has to be regulated in the extrathyroidal tissues, essentially by deiodination. like mammals and most other vertebrates, birds possess three types of iodothyronine deiodinases (d1, d2, and d3) that closely resemble their mammalian counterparts, as shown by biochemical characterization studies in several avian species and by cdna cloning of the three enzymes ... | 2006 | 16487010 |
| thyroid function in humans with morbid obesity. | morbidly obese subjects may present with abnormal thyroid function tests but the reported data are scarce. therefore, we studied the thyroid parameters in 144 morbidly obese patients, 110 females and 34 males, to assess the prevalence of hypothyroidism. eleven percent (11.8%) carried the diagnosis of hypothyroidism and were undergoing levothyroxine (lt4) replacement therapy, 7.7% had newly diagnosed subclinical hypothyroidism, 0.7% had subclinical hyperthyroidism and 7.7% were euthyroid with pos ... | 2006 | 16487017 |
| effect of experimental and cold exposure induced hyperthyroidism on h2o2 production and susceptibility to oxidative stress of rat liver mitochondria. | to investigate the iodothyronine role in liver responses to cold, we examined metabolic and oxidative mitochondrial changes in cold-exposed, t3-treated, and t4-treated rats, which exhibit different t4 serum levels. all treatments increased mitochondrial respiration which reached the highest and lowest values after t3 and cold treatment, respectively. the t3- and t4-induced changes agreed with the respective increases in complex iv activities, while those elicited by cold were inconsistent with i ... | 2006 | 16487474 |
| comparison of bactericidal activity of six lysozymes at atmospheric pressure and under high hydrostatic pressure. | the antibacterial working range of six lysozymes was tested under ambient and high pressure, on a panel of five gram-positive (enterococcus faecalis, bacillus subtilis, listeria innocua, staphylococcus aureus and micrococcus lysodeikticus) and five gram-negative bacteria (yersinia enterocolitica, shigella flexneri, escherichia coli o157:h7, pseudomonas aeruginosa and salmonella typhimurium). the lysozymes included two that are commercially available (hen egg white lysozyme or hewl, and mutanolys ... | 2006 | 16487612 |
| gustatory side effects after thoracoscopic sympathectomy. | compensatory sweating is a frequent side effect after thoracoscopic sympathectomy for primary hyperhidrosis. gustatory sweating is less commonly reported. it is defined as facial sweating when eating certain foods (particularly spicy food or acidic fruits) and has no generally accepted pathophysiologic explanation. we decided to investigate this phenomenon in patients who underwent thoracoscopic sympathectomy for primary hyperhidrosis and analyze whether the occurrence was influenced by the exte ... | 2006 | 16488719 |
| endoscopic thoracic sympathectomy for severe hyperhidrosis: impact of restrictive denervation on compensatory sweating. | compensatory sweating is noted frequently after sympathectomy and may be difficult to control in some patients. this prospective trial was projected to measure the impact of limited denervation on compensatory sweating while performing endoscopic thoracic sympathectomy. | 2006 | 16488721 |
| genotyping of pathogenic acanthamoebae isolated from clinical samples in greece--report of a clinical isolate presenting t5 genotype. | amoebae belonging to the genus acanthamoeba are potentially pathogenic to humans, causing mainly amoebic keratitis. pathogenic ability of the 15 known acanthamoeba genotypes is under investigation. we report that four out of five cases of amoebic keratitis studied in greece, present t4 sequence type, while the remaining one presents t5 sequence type (acanthamoeba lenticulata), which is the second most frequent genotype found among environmental samples. thus, it is confirmed, for the first time ... | 2006 | 16490381 |
| early and enduring nutritional and functional results of pylorus preservation vs classic whipple procedure for pancreatic cancer. | there have been many supportive data that the pylorus-preserving pancreatoduodenectomy (pppd) might be equal to the classic whipple pancreatoduodenectomy (pd) in terms of oncological radicality. however, few reports are available on the early postoperative and enduring functional changes, nutritional status, body composition, and quality of life years after surgery. the aim of this study was to compare nutritional and functional results of the different techniques in a retrospective evaluation a ... | 2006 | 16491403 |
| dna hydrolysis promoted by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane. | several acyclic and macrocyclic polyamines were evaluated for their ability to cleave dna. 1,7-dimethyl-1,4,7,10-tetraazacyclododecane (dmc) could hydrolyze double-strand dna at a concentration of 25microm. ph 7.2 was the optimal condition to cleave dna in the presence of dmc. supercoiled dna hydrolytic cleavage by dmc was supported by the evidence from free radical quenching and t4 ligase ligation. | 2006 | 16495052 |
| vestibular evoked potentials (vseps) in patients with severe to profound bilateral hearing loss. | to confirm the exclusive vestibular dependence of the evoked potentials (p10 and n15) recorded in normal subjects, by recording the potentials evoked in response to bone-conducted sound stimulation in patients with bilateral hearing loss. | 2006 | 16497555 |
| [the value of chest ct-scanning for staging of progressed or recurrent head and neck squamous cell carcinomas (hnscc)]. | at time of diagnosis, up to 17 % of hnscc present with distant metastasis or a second primary tumour. distant metastases of these tumours most commonly occur in the lung, requiring a particularly precise evaluation of this organ within the staging process. it was the aim of this study to compare the radiological findings of plain chest x-rays with the results of ct-scans of the chest in regard to their sensitivity for metastasis detection. | 2006 | 16498537 |
| changes in thyroid and vitamin a status in mink fed polyhalogenated-aromatic-hydrocarbon-contaminated carp from the saginaw river, michigan, usa. | a study was conducted to determine whether changes in thyroid and vitamin a dynamics were induced in ranch mink exposed to environmentally relevant concentrations of polyhalogenated aromatic hydrocarbons. adult female mink were fed diets that contained 0% (control), 10%, 20%, or 30% wild carp (cyprinus carpio) collected from the saginaw river, michigan, usa. total polychlorinated biphenyls concentrations were 0.03, 0.83, 1.05, and 1.69 mg/kg feed, respectively; the 2,3,7,8-tetrachlorodibenzo-p-d ... | 2006 | 16499904 |
| the relationship between iron status and thyroid hormone concentration in iron-deficient adolescent iranian girls. | extensive data from animal and human studies indicate that iron deficiency impairs thyroid metabolism. the aim of this study was to determine thyroid hormone status in iron-deficient adolescent girls. by stepwise random sampling from among all public high schools for girls in lar and its vicinity in southern iran, 103 out of 431 iron deficient subjects were selected. urine and serum samples were collected and assayed for urinary iodine and serum ferritin, iron, total iron binding capacity (tibc) ... | 2006 | 16500878 |
| the influence of xenon on regulation of the autonomic nervous system in patients at high risk of perioperative cardiac complications. | as xenon anaesthesia (xe) does not produce haemodynamic depression its use may be of benefit in patients at high risk of intraoperative haemodynamic instability and perioperative cardiac complications. xe (n=22) was compared with total i.v. anaesthesia (tiva, n=22) for differences in autonomic regulation, peri- and postoperative performance. | 2006 | 16500952 |
| a key cause of paraphimosis. | a 90-year-old man on hormonal treatment for invasive (t4) adenocarcinoma of the prostate presented as an emergency with a paraphimosis secondary to placement of four circumferential key rings around his penis. he had experienced referred penile pain from his prostate cancer, and to overcome this, had attempted to 'gate out' his pain by constricting his penis and thus stimulating the pudendal nerve. his treatment in our unit consisted of a penile local anaesthetic block, removal of the key rings ... | 2006 | 16502063 |
| dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies. | formation of a noncanonical base pair between dftp, a dttp analogue that cannot form h bonds, and the fluorescent base analogue 2-aminopurine (2ap) was studied in order to discover how the bacteriophage t4 dna polymerase selects nucleotides with high accuracy. changes in 2ap fluorescence intensity provided a spectroscopic reporter of the nucleotide binding reactions, which were combined with rapid-quench, pre-steady-state reactions to measure product formation. these studies supported and extend ... | 2006 | 16503638 |
| endothelial apoptosis and circulating endothelial cells after bypass grafting with and without cardiopulmonary bypass. | we compared profiles of the numbers of circulating endothelial cells (cec) and the apoptosis-inducing capacity of serum samples on human endothelial cells (hec) in on-pump and off-pump coronary artery bypass grafting (cabg) patients. | 2006 | 16504531 |
| concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: a pilot phase ii study of a new combined-modality paradigm. | cetuximab is a chimeric monoclonal antibody that targets the epidermal growth factor receptor. cetuximab has activity in squamous cell carcinoma and enhances both chemotherapy and radiotherapy. we conducted a pilot phase ii study of a new combined-modality paradigm of targeted therapy (cetuximab) with chemoradiotherapy. | 2006 | 16505426 |
| [evaluation and diagnosis of patients with developmental delay: standardised protocols from the paediatric point of view]. | the identification of the causes of mental retardation (mr) is of great importance because of the consequences it has in the intervention, prognosis, knowledge of risk of recurrence and its prevention. the purpose of this review is to provide a global evaluation of the child with developmental delay or with mr in day-to-day clinical praxis of the neuropaediatrician who has to put aetiological diagnosis in practice. | 2006 | 16506141 |
| daily intake of probiotic as well as conventional yogurt has a stimulating effect on cellular immunity in young healthy women. | the aim of this work was to study the effects of daily yogurt consumption on the cellular immunity of young healthy women and to compare a conventional with a probiotic product. | 2006 | 16508257 |
| dopamine infusion and anterior pituitary gland function in very low birth weight infants. | previous studies demonstrated that dopamine infusion reduces plasma concentration of thyroxine (t4), thyroid stimulating hormone (tsh), prolactin (prl), and growth hormone (gh) in adults, children, and infants. | 2006 | 16508259 |
| [effects of levothyroxine replacement on lipid profile in patients with mild subclinical hypothyroidism]. | to evaluate the effects of levothyroxine (l-t4) replacement on lipoprotein profile in patients with mild subclinical hypothyroidism, defined as a serum tsh level between 5 to 10 mu/l with a normal serum free thyroxine level. | 2006 | 16510065 |
| does prenatal screening influence anxiety levels of pregnant women? a longitudinal randomised controlled trial. | questions addressed are: (1) does offering prenatal screening increase anxiety? (2) does receiving a negative screening result make women less anxious and does a positive screening result make women more anxious? (3) what are the long-term consequences on anxiety of offering screening and receiving a screening result? | 2006 | 16511902 |
| a critical coiled coil motif in the small terminase, gp16, from bacteriophage t4: insights into dna packaging initiation and assembly of packaging motor. | double-stranded dna packaging in bacteriophages is driven by one of the most powerful force-generating molecular motors reported to date. the phage t4 motor is composed of the small terminase protein, gpl6 (18kda), the large terminase protein, gp17 (70kda), and the dodecameric portal protein gp20 (61kda). gp16, which exists as an oligomer in solution, is involved in the recognition of the viral dna substrate, the very first step in the dna packaging pathway, and stimulates the atpase and packagi ... | 2006 | 16513134 |
| lack of association between serum tsh or free t4 and body mass index in euthyroid subjects. | there is ongoing debate regarding the influence of minor changes in thyroid status within the normal range and body mass index (bmi). overt thyroid dysfunction is well recognized to affect weight, but the influence of minor perturbations of thyroid function remains unclear. | 2006 | 16430708 |
| thyroid and hypoxic stress in the newt triturus carnifex. | when specimens of the newt triturus carnifex, under anaesthesia by submersion in a 0.2% chlorbutol solution for 25 min, are isolated in a respiratory chamber at 18 degrees c containing water with only 1.3 ppm of oxygen, they consume the oxygen completely in about 3 hr, but they can stay alive for many more hours and wake up with no apparent exterior consequences. hypoxia induces rapid onset of hepatic steatosis and melanosis, as well as a controlled haemolytic process involving a pool of red blo ... | 2006 | 16432885 |
| effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish. | some ubiquitous pollutants of the aquatic environment, such as pcbs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. in a partial life cycle assay with zebrafish (danio rerio), we studied the effects of the reference compound propylthiouracil (ptu) on reproduction, growth and development, histopathology of some target tissues, and plasma thyroid hormone levels. ptu induced a concentration-dependent increase of egg production with a concomitant decrease of m ... | 2006 | 16433335 |
| activation of coagulation during hemodialysis: effect of blood lines alone and whole extracorporeal circuit. | activation of coagulation during hemodialysis (hd) is a relevant clinical problem, especially when patients at risk of bleeding are treated. however, little is known about the relative contribution of the various components of the circuit to the thrombotic process. thus, an experimental model was developed that is aimed at evaluating biochemical markers of coagulation activation at different times and sites throughout the hd circuit. a hd blood-tubing set with integrated arterial and venous cham ... | 2006 | 16433843 |
| tumour features in the control and screening arm of a randomized trial of prostate cancer. | to compare tumour characteristics at the time of diagnosis of cancers detected in the screening and control arm at the rotterdam section of the european randomized study of screening for prostate cancer. | 2006 | 16434136 |
| whole genome amplification of plasma-circulating dna enables expanded screening for allelic imbalance in plasma. | apoptotic and necrotic tumor cells release dna into plasma, providing an accessible tumor biomarker. tumor-released plasma-circulating dna can be screened for tumor-specific genetic changes, including mutation, methylation, or allelic imbalance. however, technical problems relating to the quantity and quality of dna collected from plasma hinder downstream genetic screening and reduce biomarker detection sensitivity. here, we present a new methodology, blunt-end ligation-mediated whole genome amp ... | 2006 | 16436631 |
| squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin. | treatment outcomes for squamous cell carcinoma of the temporal bone were evaluated regarding stage, therapeutic strategy, and prognostic factors. | 2006 | 16436996 |
| a dominant-negative human growth hormone-releasing hormone (ghrh) receptor splice variant inhibits ghrh binding. | ghrh is a hypothalamic peptide that stimulates the synthesis and secretion of gh from pituitary somatotroph cells. the ghrh receptor is a seven-transmembrane g protein-coupled receptor that localizes to the surface of somatotroph cells and binds ghrh. alternative splicing of the ghrh receptor primary transcript at the intron/exon boundary 3' of exon 11 results in inclusion of sequence that is normally intronic. in the human, this inclusion has an in-frame premature stop codon, and this variant m ... | 2006 | 16423869 |
| grand canonical monte carlo simulation of ligand-protein binding. | a new application of the grand canonical thermodynamics ensemble to compute ligand-protein binding is described. the described method is sufficiently rapid that it is practical to compute ligand-protein binding free energies for a large number of poses over the entire protein surface, thus identifying multiple putative ligand binding sites. in addition, the method computes binding free energies for a large number of poses. the method is demonstrated by the simulation of two protein-ligand system ... | 2006 | 16426059 |
| unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (suncus murinus, insectivora: soricidae). | the active hormone, 3,3',5-triiodothyronine (t3) is derived from thyroxine (t4) by the action of iodothyronine 5'-deiodinases (5'-d). by now two types of 5'-d have been identified; type 1 (d1) and type 2 (d2). a relative contribution of these isotypes to the circulating t3 levels in the human remains to be determined whereas a number of reports indicate that, under physiological conditions, d1 plays a major role in maintaining circulating t3 levels in rodents. in both human and rodents, sickness ... | 2006 | 16426605 |
| the control mechanism for lagging strand polymerase recycling during bacteriophage t4 dna replication. | given the polarity of dna duplex, replication by the leading strand polymerase is continuous whereas that by the lagging strand polymerase is discontinuous proceeding through okazaki fragments. yet the respective polymerases act processively, implying that the recycling of the lagging strand polymerase is a controlled process. we demonstrate that the rate of the lagging strand polymerase relative to that of fork movement affects okazaki fragment size and generates ssdna gaps. we show by using a ... | 2006 | 16427006 |
| a new method for the 3d measurement of postoperative swelling following orthognathic surgery. | to describe a new method for measuring facial swelling following orthognathic surgery using a 3d laser-scanning device. | 2006 | 16420272 |
| a screening for the occurrence of autoreactive antibodies in sera of pregnant and non-pregnant bitches. | sera of healthy pregnant (group i, n = 11) and non-pregnant (group ii, n = 11) bitches were screened for autoantibodies (aab). in both groups, blood samples were drawn every fifth day between days 5 and 55 after mating. serum was analysed via indirect immunofluorescence (iif) with the canine ana hep-2 screening kit. in all animals, anticytoplasmic aab were detected. utilizing primate-heart substrate slides aab against contractile proteins of the cytoplasm could be observed. the predominating flu ... | 2006 | 16420328 |
| interpretation of scintigraphic findings of oral malignant tumours with a new scanning agent of technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (tc-99m-mibi). | the purpose of this study was to investigate the usefulness of a new scanning agent of technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (tc-99m-mibi) for the diagnosis of malignant tumours of the head and neck. | 2006 | 16421260 |
| effect of high-frequency jet ventilation on oxygenation during one-lung ventilation in patients undergoing thoracic aneurysm surgery. | to evaluate the effect of high-frequency jet ventilation (hfjv) and continuous positive airway pressure (cpap) on oxygenation and the shunt fraction (qs/qt) during one-lung ventilation (olv). | 2006 | 16421668 |
| taiwanese vegetarians have higher insulin sensitivity than omnivores. | the present study was designed to examine the effects of habitual consumption of taiwanese vegetarian diets on hormonal secretion, and on lipid and glycaemic control. of the ninety-eight healthy female adults recruited from hualien, taiwan (aged 31-45 years), forty-nine were buddhist lactovegetarians and forty-nine were omnivores. dietary intakes were measured, and blood levels of nutrients and hormones were analysed. vegetarians consumed less energy, fat and protein, but more fibre than the omn ... | 2006 | 16441925 |
| reconstruction of large defects postmandibulectomy for oral cancer using plates and myocutaneous flaps: a long-term follow-up. | a series of 28 consecutive cases of mandibular reconstruction by means of reconstructive plates and myocutaneous flaps were reviewed. in all cases mandibular resection was indicated for treatment of squamous cell carcinoma of the oral cavity: 25 pelviglossomandibulectomies (resulting in large defects from the angle of the mandible), 2 commando operations (resulting in lateral defects) and 1 anterior sectional mandibulectomy (resulting in an anterior defect). tumour stages were t1-t2 (4 cases) an ... | 2006 | 16442779 |
| effect of selenium supplementation on thyroid hormone levels and selenoenzyme activities in growing lambs. | the aim of the present study was to evaluate the effects of selenium supplementation on thyroid hormone metabolism and selenoenzyme activities in lambs. twelve 20-d-old male lambs were assigned to one of two diets: a (0.11 ppm se) and b (supplemented with 0.2 ppm selenium as sodium selenite). blood samples were collected weekly for the determination of t3, t4, and selenium levels. the response to thyrotropin-releasing hormone (trh) challenge was estimated at the 11th and 20th wk. animals were sl ... | 2006 | 16444004 |
| dda helicase unwinds a dna-pna chimeric substrate: evidence for an inchworm mechanism. | helicases are ubiquitous enzymes involved in all aspects of dna metabolism including replication, repair, recombination, and transcription. the mechanism of the bacteriophage t4 dda helicase was investigated by preparing a dna-pna chimeric substrate. surprisingly, dda was able to unwind a substrate containing 12 pna moieties in the loading strand of the enzyme. we suggest a mechanism whereby the dda helicase contains two distinct dna binding domains which allow an inchworm mechanism for transloc ... | 2006 | 16439125 |
| early cardiac hypertrophy induced by thyroxine is accompanied by an increase in vegf-a expression but not by an increase in capillary density. | cardiac hypertrophy in response to hyperthyroidism is well known. however, the effects on cardiac microcirculation are still controversial in this model. the present study evaluated the effects of acute administration of two different thyroxine (t4) dose levels on the angiogenic response in the myocardium. capillary density (cd), the cd to fiber density (fd) ratio (cd/fd), and intercapillary distance (icd) were assessed, as was ventricle weight (vw) to body weight (bw) ratio (vw/bw). collagen i ... | 2006 | 16440199 |
| [preclinical diagnosis of traumatic paraplegia or tetraplegia -- a prospective study in 100 patients]. | to avoid neurological deterioration, traumatic spinal cord injury has to be recognized as early as possible. aim of the study was to analyze alterations of the neurological level of injury in the preclinical interval. | 2006 | 16440253 |
| usefulness of endoscopic ultrasonography in preoperative tnm staging of gastric cancer. | to evaluate the value of endoscopic ultrasonography (eus) in the preoperative tnm staging of gastric cancer. | 2006 | 16440415 |
| [the practice guideline 'carcinoma of the oral cavity and oropharynx']. | with a total incidence of ca. 800 per year, oral cavity or oropharyngeal carcinoma represents only a small fraction of the total number of cases of cancer in the netherlands. in order to achieve as much nationwide uniformity as possible in its diagnosis, treatment, after-care and follow-up, a practice guideline has now been developed. the diagnosis of the primary tumour and the neck, careful clinical examination is complemented by echography, often combined with a biopsy, mri and ct, while techn ... | 2006 | 16440562 |
| [poorly differentiated thyroid carcinomas: new therapeutic considerations]. | for most differentiated thyroid carcinomas, as papillary and follicular carcinomas, following total thyroidectomy and 131i therapy for thyroid remnant ablation, treatment with thyroid hormones to suppress tsh levels will reduce the growth of any remaining thyroid cancer cells, and thyroid cell-specific radiation therapy will either cure or control the disease. thyroid carcinomas are considered poorly differentiated when they start to lose such functions as iodine uptake and thyrotropin-dependenc ... | 2006 | 16444353 |
| randomized phase ii study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: radiation therapy oncology group trial 0012. | to evaluate the rate of pathologic complete response and toxicity of neoadjuvant chemoradiation for advanced t3/t4 distal rectal cancers in a randomized phase ii study | 2006 | 16446336 |
| neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. | to evaluate neoadjuvant capecitabine/oxaliplatin before chemoradiotherapy (crt) and total mesorectal excision (tme) in newly diagnosed patients with magnetic resonance imaging (mri) -defined poor-risk rectal cancer. | 2006 | 16446339 |
| endoscopic ultrasonography for gastric cancer: does it influence treatment? | this study aimed to evaluate the utility and shortcomings of endoscopic ultrasound (eus) in tumor node metastasis (tnm) staging of gastric cancer and its influence on treatment. | 2006 | 16446988 |
| charge reduced electrospray size spectrometry of mega- and gigadalton complexes: whole viruses and virus fragments. | the ability to analyze and identify large macromolecular complexes whose molecular weight is beyond the analyzable range of mass spectrometry is of great interest. the size of such complexes makes them suitable for analysis via mobility size spectrometry. in this work, charge reduced electrospray size spectrometry was used for the analysis of bacteriophage viruses with total molecular masses ranging from 3.6 mda up to the gigadalton range. the electrospray source used was operated in "cone jet" ... | 2006 | 16448059 |
| association of circulating antibodies against double-stranded and single-stranded dna with thyroid autoantibodies in graves' disease and hashimoto's thyroiditis patients. | the occurrence of antinuclear antibody (ana), rheumatoid factor (rf), antibodies to double-stranded dna (anti-dsdna) and to single-stranded dna (anti-ssdna) was investigated in 51 patients with autoimmune thyroid diseases (aitd), and in 25 matched control subjects. in comparison with controls, the prevalence of anti-dsdna was 74.5% in aitd patients (p=0.0001), 82.0% in 39 hyperthyroid graves' disease (gd) (p=0.0001), and 50.0% in 12 euthyroid hashimoto's thyroiditis (ht) patients (p=0.0001). the ... | 2006 | 16450315 |
| beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. | current therapeutic approaches to cancer are designed to target molecules that contribute to malignant behavior but leave normal tissues intact. beta(1) integrin is a candidate target well known for mediating cell-extracellular matrix (ecm) interactions that influence diverse cellular functions; its aberrant expression has been implicated in breast cancer progression and resistance to cytotoxic therapy. the addition of beta(1) integrin inhibitory agents to breast cancer cells at a single-cell st ... | 2006 | 16452209 |
| the bacteriophage t4 inhibitor and coactivator asia inhibits escherichia coli rna polymerase more rapidly in the absence of sigma70 region 1.1: evidence that region 1.1 stabilizes the interaction between sigma70 and core. | the n-terminal region (region 1.1) of sigma70, the primary sigma subunit of escherichia coli rna polymerase, is a negatively charged domain that affects the dna binding properties of sigma70 regions 2 and 4. region 1.1 prevents the interaction of free sigma70 with dna and modulates the formation of stable (open) polymerase/promoter complexes at certain promoters. the bacteriophage t4 asia protein is an inhibitor of sigma70-dependent transcription from promoters that require an interaction betwee ... | 2006 | 16452409 |
| expression of highly toxic genes in e. coli: special strategies and genetic tools. | escherichia coli (e. coli) remains the most efficient widely-used host for recombinant protein production. well-known genetics, high transformation efficiency, cultivation simplicity, rapidity and inexpensiveness are the main factors that contribute to the selection of this host. with the advent of the post-genomic era has come the need to express in this bacterium a growing number of genes originating from different organisms. unfortunately, many of these genes severely interfere with the survi ... | 2006 | 16472168 |
| effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat f0- and f1-generations. | chlorpyrifos-methyl (cpm) suppressed androgenic activity in hershberger assay using castrated rats. acute oral lowest-observed-adverse-effect-level (loael) and no-observed-adverse-effect-level (noael) was evaluated as 12 and 0.1 mg/kg bw, respectively, based on its major effect of cholinesterase inhibition. also, repeated oral noael was 0.1 mg/kg bw/day based on adrenal damage in rats. we investigated one-generation reproductive toxicity of cpm focusing on endocrine-disrupting effects by the adm ... | 2006 | 16472551 |
| antioxidant status and oxidative stress in professional rugby players: evolution throughout a season. | physical training is known to increase the antioxidant defence system and reduce exercise-induced oxidative stress. however, intense physical aerobic and anaerobic training and competition such as those imposed on professional rugby players, can induce an increase of oxidative stress which can be implicated with the arrival of overtraining. the aim of this study was to test the effect of training and competition load on oxidative stress, antioxidant status, haematological, and cell damage marker ... | 2006 | 16475052 |
| expression of cancer testis antigens in head and neck squamous cell carcinomas. | there is considerable interest in the expression of cancer testis (ct) antigens in human cancers, because they may serve as the basis for diagnostic tests or an immunologic approach to therapy, or as prognostic markers. | 2006 | 16475205 |
| the l561a substitution in the nascent base-pair binding pocket of rb69 dna polymerase reduces base discrimination. | several variants of rb69 dna polymerase (rb69 pol) with single-site replacements in the nascent base-pair binding pocket are less discriminating with respect to noncomplementary dnmp incorporation than the wild-type enzyme. to quantify the loss in base selectivity, we determined the transient-state kinetic parameters for incorporation of correct and all combinations of incorrect dnmps by the exonuclease-deficient form of one of these rb69 pol variants, l561a, using rapid chemical quench assays. ... | 2006 | 16475809 |
| a biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2. | this study was undertaken to define matrix metalloproteinase (mmp) expression in the anterior and posterior wall of descending thoracic aortic aneurysms (taas) and correlate it with specific computed tomography (ct) image sites within the descending thoracic aorta. | 2006 | 16476613 |
| correction of osteoporotic fracture deformities with global sagittal imbalance. | osteoporotic spinal deformities with global sagittal imbalance have devastating effects on patients. however, treatment is difficult and there is a high risk of perioperative medical and mechanical complications. patients with osteoporotic spinal deformities are not ideal candidates for posterior pedicle subtraction osteotomy; the condition necessitates combined anterior-posterior for corrections of the deformity. we ascertained the complication rates and efficacy of the anterior-posterior surge ... | 2006 | 16462430 |
| definitive radiotherapy for squamous cell carcinoma of the base of tongue. | to evaluate definitive radiotherapy (rt) for treatment of base of tongue cancer. | 2006 | 16462500 |
| carcinoma of the buccal mucosa: analysis of clinical presentation, outcome and prognostic factors. | records of 100 consecutive cases of carcinoma of the buccal mucosa treated in our institute between january 2000 and december 2003 were analyzed for clinical presentation, patterns of care, disease-free survival (dfs) and prognostic factors. there were 75 males and 25 females. the mean age was 50 years. ninety five gave a history of abuse of oral tobacco products. only 20 patients were in stage i or ii. sixty one patients had stage iv disease. sixty six patients were treated with radical intent ... | 2006 | 16464632 |
| [endocrinology]. | there is now convincing evidence that the risks of hormone replacement therapy in post-menopausal women exceed its benefits. similarly, it has now been shown that the current use of low-dose oral contraceptives significantly increases the risk for cardiac and arterial thrombotic events. with regard to hypothyroidism, it is now clearly established that the adjunction of t3 to t4 does not offer any benefits. furthermore, a study has now demonstrated that patients with no symptoms of coronary heart ... | 2006 | 16465939 |
| thyroid hormone profile during annual reproductive cycle of diploid and triploid catfish, heteropneustes fossilis (bloch). | triploid fishes generally show sterility along with retarded gonadal development and aneuploid gametes. in teleosts, thyroid hormones influence seasonal adaptations and annual events such as reproduction. in addition, thyroid hormone deposition in matured ova is important for reproductive success as the role of thyroid hormones in early development and metamorphosis is well established. the present study deals with measurements of free and total thyroxine (t4) and triiodothyronine (t3) in the pl ... | 2006 | 16466725 |
| perineural invasion has no prognostic value in patients with invasive breast carcinoma. | no studies examining the relationship between perineural invasion (pni) and clinicopathological factors in invasive breast cancer have been published. therefore, we investigated this association and analyzed the effect of pni on disease-free survival (dfs) in patients with invasive breast carcinoma. pni evaluation was performed on hematoxylin- and eosin-stained tissue sections of surgical specimens from 377 patients. pni was assessed as positive when cancer cells were seen in the perineurium or ... | 2006 | 16466917 |
| three-week thyroxine withdrawal: a thyroid-specific quality of life study. | the purpose of this study is to determine the impact of a 3-week t4 withdrawal test on the quality of life (qol) of patients undergoing investigation for residual/recurrent well-differentiated thyroid cancer. | 2006 | 16467714 |
| [effects of a programme for structured outpatient follow-up care after inpatient rehabilitation of obese children and adolescents--a multicentre, randomized study]. | inpatient rehabilitation is an important contributor to the treatment of child and adolescent obesity with comorbidity in germany. thus far outpatient follow-up care has not been subject to research. the main goal of this study is the development and longer-term evaluation of a programme for structured outpatient follow-up care by primary care physicians after inpatient rehabilitation of obese children and adolescents. | 2006 | 16468112 |
| prognostic value of thrombocytosis in renal cell carcinoma. | we correlated platelet count to renal tumor characteristics, and evaluated the potential prognostic value of thrombocytosis in localized and metastatic tumors. | 2006 | 16469566 |
| renal cell carcinoma with nodal metastases in the absence of distant metastatic disease (clinical stage txn1-2m0): the impact of aggressive surgical resection on patient outcome. | nodal disease in the setting of metastatic renal cell carcinoma is associated with poor prognosis. however, to our knowledge the biology of nodal metastases in the absence of metastatic disease is unknown. we reviewed our experience with treating this subset of patients with aggressive surgical resection. | 2006 | 16469567 |
| comparison of anterior and posterior double-rod instrumentation for thoracic idiopathic scoliosis: results of 141 patients. | ventral derotation spondylodesis, according to zielke, achieves good results in operative treatment of idiopathic thoracic scolioses. corrections of scoliotic major and secondary curve as well as derotation of the spine are reliably performed. the high rate of rod fractures with subsequent correction loss as well as a proportionate kyphogenic effect represents a problem. by keeping to the correcting principle, anterior double-rod instrumentation (halm-zielke instrumentation) is to be stable in a ... | 2006 | 16470398 |
| the gross anatomy of the extrathoracic course of the intercostobrachial nerve. | recent reports emphasize the importance of preserving the intercostobrachial nerve (icbn) during surgical procedures (i.e., mastectomy, axillary clearance). however, a limited number of scientific reports explore the surgical anatomy of this nerve. we dissected 100 adult human formalin-fixed cadavers (200 axillae). in all the cadavers the icbn was present with variant contributions from intercostal nerves t1, t2, t3, and t4. the arrangements of the icbn were typed as i through viii. the componen ... | 2006 | 16470542 |
| supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer. | supracricoid laryngectomy with cri-cohyoidoepiglottopexy (chep) is a conservative surgical procedure indicated in selected cases of advanced glottic carcinoma. | 2006 | 16470876 |
| increasing illness severity in very low birth weight infants over a 9-year period. | recent reports have documented a leveling-off of survival rates in preterm infants through the 1990's. the objective of this study was to determine temporal changes in illness severity in very low birth weight (vlbw) infants in relationship to the outcomes of death and/or severe ivh. | 2006 | 16460568 |
| biocontrol of the food-borne pathogens listeria monocytogenes and salmonella enterica serovar poona on fresh-cut apples with naturally occurring bacterial and yeast antagonists. | fresh-cut apples contaminated with either listeria monocytogenes or salmonella enterica serovar poona, using strains implicated in outbreaks, were treated with one of 17 antagonists originally selected for their ability to inhibit fungal postharvest decay on fruit. while most of the antagonists increased the growth of the food-borne pathogens, four of them, including gluconobacter asaii (t1-d1), a candida sp. (t4-e4), discosphaerina fagi (st1-c9), and metschnikowia pulcherrima (t1-e2), proved ef ... | 2006 | 16461659 |
| isolation and characterization of a cyanophage infecting the toxic cyanobacterium microcystis aeruginosa. | we isolated a cyanophage (ma-lmm01) that specifically infects a toxic strain of the bloom-forming cyanobacterium microcystis aeruginosa. transmission electron microscopy showed that the virion is composed of anisometric head and a tail complex consisting of a central tube and a contractile sheath with helical symmetry. the morphological features and the host specificity suggest that ma-lmm01 is a member of the cyanomyovirus group. using semi-one-step growth experiments, the latent period and bur ... | 2006 | 16461672 |
| construction and complementation of in-frame deletions of the essential escherichia coli thymidylate kinase gene. | this work reports the construction of escherichia coli in-frame deletion strains of tmk, which encodes thymidylate kinase, tmk. the tmk gene is located at the third position of a putative five-gene operon at 24.9 min on the e. coli chromosome, which comprises the genes pabc, yceg, tmk, holb, and ycfh. to avoid potential polar effects on downstream genes of the operon, as well as recombination with plasmid-encoded tmk, the tmk gene was replaced by the kanamycin resistance gene kka1, encoding amin ... | 2006 | 16461678 |
| adaptive radiotherapy for invasive bladder cancer: a feasibility study. | to evaluate the feasibility of adaptive radiotherapy (art) in combination with a partial bladder irradiation. | 2006 | 16458776 |
| [t4-type bacteriophages: ubiquitous components of the "dark matter" of the biosphere]. | 2006 | 16457745 | |
| surgical outcomes in patients with t4 gastric carcinoma. | there is controversy about the best therapeutic surgical approach for treatment of patients with t4 gastric cancer. | 2006 | 16427546 |
| structure-function analysis of the kinase-cpd domain of yeast trna ligase (trl1) and requirements for complementation of trna splicing by a plant trl1 homolog. | trl1 is an essential 827 amino acid enzyme that executes the end-healing and end-sealing steps of trna splicing in saccharomyces cerevisiae. trl1 consists of two domains--an n-terminal ligase component and a c-terminal 5'-kinase/2',3'-cyclic phosphodiesterase (cpd) component--that can function in trna splicing in vivo when expressed as separate polypeptides. to understand the structural requirements for the kinase-cpd domain, we performed an alanine scan of 30 amino acids that are conserved in t ... | 2006 | 16428247 |
| combined spinal epidural causes higher level of block than equivalent single-shot spinal anesthesia in elective cesarean patients. | combined spinal epidural (cse) is an established technique for lower segment cesarean delivery. in this study we tested the hypothesis that the spinal block from a cse technique results in a more extensive spread of local anesthetic in the subarachnoid space than the single-shot spinal (sss) technique. we recruited 30 asa physical status i parturients admitted for elective lower segment cesarean delivery into our randomized, controlled, double-blind study. all patients intrathecally received 2 m ... | 2006 | 16428564 |
| role of radiotherapy with surgery for t3 and resectable t4 rectal cancer: evidence from randomized trials. | the main treatment for resectable rectal cancer t2-t4 n0-n2 m0 is surgery. the benefit of preoperative or postoperative radiation therapy can be analyzed in terms of improvement of local control, sphincter preservation, and survival weighted against increased toxicity. | 2006 | 16456638 |
| measurement of total thyroxine concentration in serum from dogs and cats by use of various methods. | to compare results obtained from assay of total thyroxine (t4) concentration in serum of dogs and cats by use of 4 methods. | 2006 | 16454630 |
| interactions in developmental toxicology: concurrent exposure to perfluorooctane sulfonate (pfos) and stress in pregnant mice. | the maternal and developmental toxicity of combined exposure to restraint stress and perfluorooctane sulfonate (pfos) was assessed in mice. on gestation days 6-18, four groups of plug-positive female mice were orally exposed to pfos at 0, 1.5, 3 and 6 mg/kg/day. four additional groups of plug-positive animals received the same pfos doses being restrained during 30 min three times per day. a control group was also included. cesarean sections were performed on day 18 of gestation and fetuses were ... | 2006 | 16384669 |