Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a comparative study on the heat stability of triosephosphate isomerase in psychrophilic, psychrotrophic, and mesophilic clostridia. | the temperature stability of triosephosphate isomerase (ec 5.3.1.1) in the cell-free extracts of psychrophilic, psychrotrophic, and mesophilic clostridium species has been investigated. even though this enzyme was found to be heat labile in the psychrophilic isolates, no detectable loss in activity was evident when cell-free extracts were heated for 1/2 h at the maximum temperature of growth for the organisms. two organisms, each with a maximum growth temperature of 23 degrees c, showed differen ... | 1975 | 172205 |
| behavioral and epileptic determinants of predatory attack behavior in the cat. | this report presents studies which relate limbic epileptic excitability to behavioral measures of defensive suppression of predatory attack in cats. correlated with heightened defensiveness to environmental stimuli among non-killer cats is a heightened amygdaloid epileptic excitability, as well as a heightened conduction of amygdaloid epileptic activity to thalamic and hypothalamic substrates of predatory response in the amygdala to the complex visual stimuli presented by rat prey. these neurose ... | 1975 | 172209 |
| [identification of camp dependant protein kinases in human lymphocytes]. | chromatographic purification by "deae" cellulose resolves the camp binding proteins in human lymphocytes into three parts. in presence of mg++ each one possesses camp dependent protein-kinase activity, one of them showing allosteric characteristics. | 1975 | 172248 |
| [demonstration of antigen-antibody complex of tsv5c12 cell membranes by means of guinea pig fluorescent anti-complement antibodies]. | the application of rabbit anti-guinea pig complement fluorescent antibody to sv40 transformed cells demonstrated the presence of immune complexes on the cell membrane surface. the presence of such complexes was not detectable by using fluorescent rabbit anti-hamster immunoglobulins antisera. | 1975 | 172249 |
| [resistance to association of antibiotics (polymyxin and penicillin) in relation to cell concentration of two bacterial species in the same inoculum. complementary inoculum effect]. | dense suspensions of sa. typhi (polys penr) and of st. aureus (polyr pens) proliferate on gelose medium added with the two antibiotics only if the inoculum is mixed. the growth is probably due to the partial neutralization of the antibiotics following the formation of complexes between these antibiotics and some constituents of the two strains. | 1975 | 172250 |
| [biological study of the cell membrane function and prostaglandin]. | 1975 | 172265 | |
| integration of viral dna into the host genome. | 1975 | 172288 | |
| elevation of intracellular calcium ion concentration provokes production of 1,2-diacylglycerol and phosphatidate in human erythrocytes. | 1975 | 172387 | |
| the estrogen cytosol receptor of female ovine pituitary. | the biochemical parameters of estrone and estradiol binding to the cytosol fraction of ovine anterior pituitary were investigated. when increasing amounts of [3h]estrone or [3h]estradiol were incubated with the 105,000 g fraction from the pituitary, both hormones bound to a receptor with the same apparent kd (mean +/- s.e., estrone = 1.40 +/- 0.30 x 10(-10) m, estradiol = 1.03 +/- 0.11 x 10(-10)m) and the same concentration of binding sites (estrone = 3.22 +/- 0.58 x 10(-14) moles/mg protein, es ... | 1975 | 172395 |
| multiple regulatory events in the development of competence for genetic transformation in haemophilus influenzae. | cyclic adenosine 3',5'-monophosphate derepresses enzyme synthesis but does not yield high levels of transformability or detectable levels of competence-related envelope polypeptides. additional regulatory events must trigger complete expression of competence. | 1975 | 172489 |
| distribution of membrane-bound cyclic amp-dependent protein kinase in plasma membranes of cells of the kidney cortex. | renal cortical plasms membranes were separated by free flow electrophoresis into luminal (brush border microvilli) and contraluminal (basal-lateral membrane) fractions. these membranes were found to contain an intrinsic, self-phosphorylating system which consists of a cyclic amp-dependent protein kinase, a phosphorprotein phosphatase and the substrate(s) of these enzymes. the kinase, but not the phosphatase, was stimulated by cyclic amp; maximal (1.7-fold) stimulation was effected at a cyclic am ... | 1975 | 172638 |
| intermediate complex of atp hydrolysis and synthesis by muscle proteins. | myosin catalyzed exchange between 32pi and atp in reaction medium during its enzymatic hydrolysis of atp only by a very small amount. addition of actin increased to a great extent the rate of incorporation of 32pi in the presence of mg. glycerinated smooth muscle fibers also exhibited the ability to exchange 32pi and atp upon the application of external force (repeated stretching and releasing). a schematic mechanism of the action of actin and external force on acceleration of 32pi incorporation ... | 1975 | 172738 |
| inhibition of hepatic lipogenesis by adenine nucleotides. | incubation of liver slices and isolated liver cells with adenosine cyclic-3',5'-monophosphate at concentrations which inhibit lipogenesis was found to expand the pool size of the noncyclic adenine nucleotides in the intact cells of the preparations. this observation led to studies which demonstrated that adenosine and adenosine-5'-monophosphate also inhibited lipogenesis and expanded the adenine nucleotide pool size. it is proposed but not proven that the increase in intracellular nucleotides pr ... | 1975 | 172757 |
| a directed alteration of ribonuclease specificity. hydrolysis of polyribonucleotides containing modified cytosine bases. | the action of ribonucleases on poly and oligoribonucleotides containing cytosine bases modified by methoxyamine and bisulphite was examined. resistance of phosphodiester bonds in (cp)nxp (where n greater than or equal to 1 and x stands for a, g or u) to t2 rnase hydrolysis was observed if substrates were modified chemically. the phenomenon formed the basis for isolation of (cp)nxp blocks as an additional tool in sequence investigations. after modification of cytosine pancreatic rnase was unable ... | 1975 | 172781 |
| the effect of idoxuridine on herpes simplex virus infection in mouse skin. | 1975 | 173053 | |
| steroid receptors and hormone receptivity: new approaches in pharmacology and therapeutics. | 1975 | 173057 | |
| dna polymerase induction by dna-negative temperature-sensitive mutants of herpes simplex virus type 2. | 1975 | 173076 | |
| [serologic diagnosis of brain tumors using clostridium butyrium spores (experimental and clinical studies)]. | spores of the clostridium butyrium m 55 strain, introuduced intravenously, proliferate selectivity in tumours of individual with newgrowths forming bacilli and then multiply evoking the appearance of antibacillary antibodies. in persons with no tumours there emerge only antispore antibodies. since the spores and bacilli of this strain have antigens of a different nature their antibodies are encountered separately. the finding of antibacillary antibodies following injection of spores thus serves ... | 1975 | 173087 |
| effects of cholinergic agonists and antagonists of nucleus vestibularis lateralis unit discharge to vestibular nerve stimulation in the cat. | unit discharge in nucleus vestibularis (nvl) was studied in locally anesthetized cats. the mean firing rate +/-s.e. of spontaneous unitary discharges of nvl neurons was 19.8+/-0.9 hz and that of spinal-transected animals was 18.0+/-1.6 hz. the mean firing rate of these neurons in animals with cerebellum ablation and the administration of scopolamine in a dose of 0.5 mg/kg i.v. was relatively low. after administration of physostigmine in a dose of 25 mug/kg i.v. the firing rate was enhanced. the ... | 1975 | 173135 |
| oxygen-18 studies of the mechanism of pyrophosphoryl group transfer catalyzed by phosphoribosylpyrophosphate synthetase. | 1975 | 173242 | |
| diverse directional changes of cgmp relative to camp in e. coli. | 1975 | 173303 | |
| diadenosine triphosphate splitting by rat liver extracts. | 1975 | 173305 | |
| studies on the mode of action of calciferol. x. 24-nor-25-hydroxyvitamin d3, an analog of 25-hydroxyvitamin d3 having "anti-vitamin" activity. | 1975 | 173329 | |
| manganese as a mutagenic agent during in vitro dna synthesis. | 1975 | 173332 | |
| [structural transitions in dna, isolated from normal and neoplastic cells]. | a decrease of temperature transition in spin-labeled dna isolated from leucose cells compared with normal cells is found. it is shown by kinetic formaldehyde method that it may be the result of many defects in the secondary structure of macromolecule in dna1. the spin label method is shown to be used for the analysis of dna macromolecule damaged with small irradiation doses. various radiosensitivity of dna isolated from the blood of normal and leucose cells is observed. | 1975 | 173399 |
| [letter: epr study of bacteriorhodopsin-containing systems]. | 1975 | 173406 | |
| effects of catecholamines on rat myocardial metabolism. i. influence of catecholamines on energy-rich nucleotides and phosphorylated fraction contents. | 1. the influence of catecholamines (adrenaline and noradrenaline) on energy metabolism of the rat myocardium has been studied by incubating slices of this tissue with these hormones and by following the levels of the different phosphorylated fractions and adenylic nucleotides. 2. similar effects are obtained with both hormones, adrenaline being more effective. 3. catecholamines decrease significantly the total amount of phosphate while pi content increases during the first 10 minutes of incubati ... | 1975 | 173416 |
| interaction of spironolactone and digitalis with the 5 alpha-dihydrotestosterone (dht) receptor of rat ventral prostate. | the aldosterone antagonist, spironolactone, has been shown to block the effects of exogenously administered androgen in rat. this suggests that interaction of the drug with androgen at the target tissues may occur. in this paper we have studied the possible interaction of spironolactone with the 5alpha-dihydrotestosterone (dht)1 receptor of rat ventral prostate. the competitive receptor assay used involves precipitation of the 105,000 x g supernatant of the homogenized tissue with protamine sulf ... | 1975 | 173527 |
| nuclear protein kinases from murine cells. | three protein kinase activities are found in nuclei from three different murine cells (ehrlich ascites cells, mouse l cells and rat glioma cells). two of these activities are soluble, one is bound to chromatin. the soluble enzymes are similar, if not identical, to the cytoplasmic protein kinases. the chromatin-bound, adenosine-cyclic-3':5'-monophosphate-independent enzyme is not found in the cytoplasm. this enzyme is composed of one subunit with a molecular weight of 80000-90000. some biochemica ... | 1975 | 173539 |
| procollagen biosynthesis by embryonic-chick-bone polysomes. estimation of the relative numbers of active proalpha1 and proalpha2 messenger ribonucleic acids. | both total polysomes and polysomes of different size classes isolated from embryonic chick cranial bones were allowed to complete their nascent polypeptide chains in a cell-free system containing rabbit reticulocyte post-ribosomal supernatant fraction. in this system, no de novo initiation of polypeptide synthesis occurred. the product was analysed for relative content of proalpha1 and proalpha2, the precursors of the alpha chains of collagen, by dodecylsulphate-acrylamide gel electrophoresis as ... | 1975 | 173541 |
| [0utbreak of anaerobic enterotoxemia of calves]. | 1975 | 129914 | |
| [morphological and biochemical studies on the retinal blood vessels of streptozotocin diabetic rats (author's transl)]. | 1975 | 130794 | |
| [interpretation of the cross sectional structure of skeletal muscle fibers. 2. light and electron microscopic studies of m. rectus abdominis in rana esculenta]. | in both longitudinal and cross sections of rectus abdominis muscle of rana esculenta three types of muscle fibres are identified by means of light and electron microscopy. a comparison is made between these fibre types in homologous muscles of frog and mammals (rat and mouse). in longitudinal sections of mammalian and frog muscle the z-line can be used for discrimination of the fibre types a, b and c because that line is of different thickness in each type. the proportions of the thickness in fr ... | 1975 | 137606 |
| quantitative cloning of malignant human glioma cells by conditioned medium. | the use of conditioned medium (cm) obtained from monolayer cultures of human glioma cells induced colony formation from single glioma cells in culture. in contrast, no colonies were observed in cultures incubated with nonconditioned standard eagle's basal medium. the number of colonies formed closely depended on the concentration of cm. the glioma cm not only stimulated colony formation but also induced the formation of fibrillary cell extensions. culture conditions influencing the production o ... | 1975 | 173866 |
| natural and experimentally induced antibodies to defined mammalian type-c virus proteins in primates. | using sensitive radiommunoprecipitation assays for highly purified type-c rna tumor virus proteins, we found that 5 of 16 clinically normal gibbons (including 4 of 5 normal animals from a colony with 2 cases of lymphoma) and 4 of 4 experimentally inoculated gibbons formed antibodies to the major structural protein (p30) of gibbon ape leukemia virus (galv). an additional woolly monkey immunized with the closely related simian sarcoma virus also formed antibodies detectable with galv p30. of 20 pa ... | 1975 | 173868 |
| comparison of an avian osteopetrosis virus with an avian lymphomatosis virus by rna-dna hybridization. | myeloblastosis-associated virus (mav)-2(0), a virus which was derived from avian myeloblastosis virus and induced a high incidence of osteopetrosis, was compared with avian lymphomatosis virus 5938, a recent field isolate which induced a high incidence of lymphomatosis. the following information was obtained. (i) mav-2(0) induced osteopetrosis, nephroblastoma, and a very low incidence of hepatocellular carcinoma. no difference was seen in the oncogenic spectrum of end point and plaque-purified m ... | 1975 | 173880 |
| [clinical value of magnification cerebral angiography (author's transl)]. | magnification carotid and vertebral angiography was performed via femoral catheter with magnification factor of 2.5 to 3.0, utilizing 0.1 x 0.1 ultra fine focal spot, manufactured by shimadzu seisakusho, ltd. the standard angiograms were compared with magnification angiograms in a group of 67 patients with brain tumors and vascular disorders. the magnification angiography was more valuable than conventional angiography in 12 of 17 vascular tumors, while it was rarely valuable for diagnosis of ... | 1975 | 174021 |
| human papillomavirus dna: physical map. | human papillomavirus (hpv) dna form i (supercoiled) was prepared from plantar warts. hpv dna was cleaved with restriction enzymes obtained from the following sources: escherichia coli (ecori), hemophilus influenzae strain rd (both unfractionated hind and aeparated hindii and hindiii enzymes) and hemophilus parainfluenzae (hpai). the cleavage products were analyzed by polyacrylamide gradient slab gel electrophoresis and electron microscopy. hpv dna was cleaved into two fragments by ecori (87% and ... | 1975 | 174077 |
| determination of the number of superhelical turns in simian virus 40 dna by gel electrophoresis. | closed-circular, superhelical dna from simian virus 40 (sv40 dna i) was treated with an excess of dna-relaxing enzyme in the presence of increasing amounts of ethidium bromide (etdbr). after removal of the ethidium, each sample consisted of a group of close-circular dna molecules differing in their number of superhelical turns (tau) around a mean value of tau in a gaussian-like distribution. the dna samples were analyzed by electrophoresis in agarose gels under conditions where the electrophoret ... | 1975 | 174079 |
| intake digestion and production by dairy cows given protected lipids in early lactation. | 1975 | 174119 | |
| infectivity studies of hepatitis a and b in non-human primates. | we have induced hepatitis a in marmosets of the subspecies saguinus mystax following primary inoculation with human serum containing the ms-1 strain of hepatitis a virus (hav) and in 3 further marmoset subpassages using infective marmoset serum from each preceding passage. in each passage acquisition of serum antibody against 17 nm virus-like particles recovered from acute illness stools of human volunteers who developed hepatitis following inoculation with the ms-1 strain of hav, as well as fro ... | 1975 | 173599 |
| stimulation of water and sodium secretion and inhibition of glucose absorption from the rat jejunum during intraarterial infusions of prostglandins. | the effect of prostaglandins, isoprenaline and dibutyryl cyclic adenosine monophosphate (dibut camp) on the net transfer of water and na+ and glucose absorption have been studied in the anaesthetized rat. the lumen of the jejunum was recirculated with a solution of normal saline containing d (+) glucose and phenosulphonphthalein. the superior mesenteric artery was perfused extracorporeally and drugs were infused into the arterial blood. prostaglandin e1 (pge1) at infusion rates of 2-5 x 10(-9) a ... | 1975 | 173624 |
| proceedings: solubilization of sphingomyelinase of rat brain lysosomes. | 1975 | 173678 | |
| genital herpes simplex virus type 1 infection--variability in modes of spread. | ever since the first report in 1967 of the association of herpes simplex virus type 2 (hsv-2) with urogenital infections, we have noted the occasional isolation of hsv-1 from such sites. our most recent results of the typing of hsv isolates from 527 individuals with urogenital infections show that 10.9% of such infections in females and 3.4% in males are caused by hsv-1. we describe here the acquisition of a primary oral hsv-1 infection in a male after orogenital contact with his wife who had a ... | 1975 | 173699 |
| [different pathogenic power of the original bcg strain of the pasteur institute and of an isoniazid resistant strain. histopathological study and significance of local abscesses after inoculation of guinea pig]. | the inoculation into guinea pigs of 10 mg of bcg, obtained either from the pasteur institute original strain, or from a mutant isoniazid resistant strain, b1 catalase positive, caused in 40.4% of cases, the onset of abscesses at the point of injection. the frequency and course of these abscesses appear quite different with the two strains, 92.8% with the classical strain, persisting in more than half of the cases after one year, and 23.5% with the inh-resistant strains which regressed within 6 m ... | 1975 | 174202 |
| [use of the direct immunofluorescence method for determination of the tge viral antigen in swine]. | followed up were the appearance and accumulation of the transmissive gastroenteritis (tge) virus antigen in infected cells of pig kidney and thyroid. used were specific conjugates, such introduced by the authors and some imported from czechoslovakia. the cell cultures were infected with strains of the tge virus, isolated in bulgaria or supplied from czechoslovakia. it was found that the bulgarian strains were the same as those from czechoslovakia and the united states. a viral antigen was found ... | 1975 | 174279 |
| intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. | histological, histochemical, and ultrastructural examinations were performed on pulmonary and hepatic tissues of rats after prolonged oral treatment with several tricyclic antidepressants and two neuroleptics, which are all of amphiphilic character. the antidepressants ipindole, imipramine, clomipramine, 1-chloro-amitriptyline, and 1-chloro-10,11-dehydro-amitriptyline were found to cause an accumulation of intraalveolar foam cells accompanied by the formation of abnormal lamellated and crystallo ... | 1975 | 174284 |
| electron spin resonance spectra of chicken hepatoma and liver tissue. | when studied by electron spin resonance (esr) (swartz et al., 1972), tumorous tissues differ from their normal equivalents in the following aspects: 1. in tumourous tissues the signal measured in the vicinity of the g=2 region of the spectrum is of a smaller amplitude or completely absent (commoner et al., 1954; commoner, ternberg, 1961; mallard, kent, 1964; dodd, 1973). 2. signals attributed to certain paramagnetic metal ions are also decreased (nebert and mason, 1963; swartz et al., 1973). new ... | 1975 | 174376 |
| a comparative appraisal of emphysematous cholecystitis. | there is ample evidence from this retrospective comparison to indicate that emphysematous cholecystitis does merit clinical distinction apart from acute cholecystitis. it is an acute infection of the gallbladder caused by a specific group of bacteria that may be aided by some aspect of local ischemia. cholelithiasis does not seem to be a major factor in the pathogenesis of emphysematous cholecystitis, and this, in association with some dependence upon ischemia, may account for the predominance o ... | 1975 | 174453 |
| electron spin resonance study of changes during the development of a mouse myeloid leukaemia. ii. the ascorbyl radical. | the ascorbyl radical concentration has been observed, by means of electron spin resonance spectroscopy, in the blood, spleen and liver of rf/j female mice throughout the development of a myeloid leukaemia. changes in the concentration of the radical were detectable from an early stage in the disease and did not appear to be directly due to the leukaemic cells but could possibly be due to a reaction against them. changes in the concentration of the paramagnetic metal ions during the leukaemia hav ... | 1975 | 174704 |
| [role of phospholipids in the generation of membrane potentials by proteoliposomes]. | closed protein-phospholipid particles (proteoliposomes), obtained by self-assembly method, are capable to generate and to maintain the membrane potential in the case if their protein complex is represented by: a) a complex of mitochondrial atpase; b) a complex of cytochrome oxidase and cytochrome c and c) bacteriorhodopsin from halobacterium halobium; and their phospholipid component is represented by phosphatidylethanolamine or by a mixture of mitochondrial phospholipids. only cytochromoxidase ... | 1975 | 174754 |
| [inositol-containing phospholipids in rat brain and liver]. | a simple modification of the method of rossiter and palmer for the quantitative determination of phosphoinositides (pi) in animal tissues (brain and liver) is worked out: phospholipids are mineralyzed (together with a paper) in 57% perchloric acid, avoiding the time consuming procedure of the tenfold elution of inositids spots from chromatogramms and the subsequent evaporation of the substantial volume of the eluate obtained. the time of the analysis is twice as short as that of the original met ... | 1975 | 174755 |
| [immunologic results obtained with an experimental system oftransplantable colonic tumors. possible applications of these results to human intestinal tumors]. | intestinal cancers, morphologically very close to human colo-rectal adeno-carcinoma, have been induced by dimethylhydrazine in inbred rats. graftable lines have been obtained from 5 primary intestinal tumors, and 3 cell lines have been cultivated from the grafts. this model was used to demonstrate carcinofetal antigen(s) on the surface of the intestinal cancer cells. circulating antibodies against tumor-associated antigen(s) have been found in tumor-bearing rats. cancer enhancement was regularly ... | 1975 | 174767 |
| unusually high incidence of spontaneous mammary carcinomata in a colony of balb/c mice. | 1975 | 175817 | |
| antibody responses to a combination vaccine against haemophilus influenzae type b, diphtheria, pertussis, and tetanus. | forty-one children were studied in order to provide information on antibody responses to h. influenzae type b polyribophosphate (prp), given in combination with diphtheria-pertussis-tetanus vaccine (dpt). when prp was administered alone, 9 of 15 children demonstrated fourfold or greater increases in titres of anti-prp antibody. in contrast, in the group receiving a combination vaccine consisting of dpt and prp only 1 of 13 children showed a similar rise in anti-prp antibody. it was concluded tha ... | 1975 | 174825 |
| a receptor site for prolactin in lactating mouse mammary tissues. | prolactin iodinated by lactoperoxidase method showed immunologically, electrophoretically and biolo9gically similar properties to native prolactin and possessed enough specific radioactivity for receptor studies. 1251-prolactin was incubated with mouse mammary tissues at 8 days of lactation. both binding and release of 1251-prolactin depended on incubation time and temperature and were maximal at 37 degrees c. michaelis constant was estimated to be 1.4 x 10(-9) m from lineweaver-burk plot and to ... | 1975 | 174901 |
| [stability of some bradykinin analogues against kininase ii (author's transl)]. | some analogues of bradykinin, especially with replacements by other amino acids of phenylalanine in position 8, have been investigated for enzymatic stability against kininase ii from rat duodenum microsomes and rat uterus plasma membranes, respectively. as compared with bradykinin, two of the analogues, [8-erythro-beta-phenylserine]- and [8-erythro-alpha-amino-beta-phenylbutyric acid]-bradykinin were stable to enzymatic degradation. therefore, the latter may be used for studies in hormone-recep ... | 1975 | 174930 |
| early stimulation of human chorionic gonadotropin secretion by dibutyryl cyclic amp and theophylline in human malignant trophoblast cells in vitro: inhibition by actinomycin d, alpha-amanitin, and cordycepin. | human malignant trophoblast cells (bewo line) in culture were employed to investigate the early stimulation of human chorionic gonadotropin (hcg) secretion by 1 mm dibutyryl cyclic amp and 1 mm theophylline (dbt). the earliest increase in secreted immunoreactive hcg occurred at 3 1/2 h following addition of dbt, and was preceded by an increase in intracellular hcg. these results suggested that dbt stimulated hcg synthesis, rather than release. addition of either 0.062 mug/ml actinomycin d or 100 ... | 1975 | 174977 |
| purification and properties of the intact form of nadh-cytochrome b5 reductase from rabbit liver microsomes. | nadh-cytochrome b5 reductase [ec 1.6.2.2] has been solubilized with triton x-100 and purified to homogeneity from rabbit liver microsomes. the purified enzyme is essentially free of the detergent and phospholipids and exists in aqueous media as an oligomeric aggregate of about 13 s. its monomeric molecular weight is about 33,000 and 1 mole of fad is associated with 1 mole of the monomeric unit. the enzyme catalyzes the reductions by nadh of ferricyanide and 2,6-dichlorophenol indophenol at an ac ... | 1975 | 175049 |
| epidemic of hand, foot and mouth disease in japan, 1972-1973: difference in epidemiologic and virologic features from the previous one. | 1975 | 175202 | |
| mcf-7; a human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors. | we have identified receptors for glucocorticoids, progestins, and androgens in a human breast tumor cell line (mcf-7) known to have estrogen receptor. sucrose density gradients show that mcf-7 cytosol contains approximately 100 fm/mg protein estradiol (e2-3h) receptor, more than 300 fm/mg protein progesterone receptor (measured with r5020-3h), about 40 fm/mg protein 5alpha-dihydrotestosterone (5alpha-dht-3h) receptor, and 800 fm/mg glucocorticoid receptor (measured with dexamethasone-3h). dissoc ... | 1975 | 175527 |
| [serum lysozyme activity in chicks vaccinated against infectious laryngotracheitis via inhalation]. | 1975 | 175541 | |
| effects of cholecalciferol on the translocation of calcium by non-everted chick ileum in vitro. | an apparatus is described that allows perfusion of a non-everted segment of intestine in vitro and the study of the accumulation of substances within the mucosal cells. the translocation of ca(2+) by rachitic-chick ileum and the effect of pretreatment with cholecalciferol was investigated, with the following conclusions. (1) entry of ca(2+) across the microvilli into mucosal cells is by diffusion; it does not require metabolic energy or the presence of any other inorganic ions. (2) pretreatment ... | 1975 | 177000 |
| renal carcinogenesis. | 1975 | 175645 | |
| effect of ceruloplasmin on sendai virus multiplication in chorioallantoic membrane fragments. | three stages can be distinguished in the evolution of ha titer during sendai virus multiplication in chorioallantoic membrane (cam) fragments in relation to the age of cam and conditions of inoculation and maintenance. ceruloplasmin has an inhibitory effect on virus multiplication, more marked in the case of stationarily maintained cam fragments and dependent on the relationship between the moment of ceruloplasmin addition and of virus inoculation. maximum inhibition is achieved by inoculation o ... | 1975 | 178090 |
| [traumatic deciduoma and delayed nidation in castrated pregnant rat after acth injection]. | after administration of acth it is possible to obtain traumatic deciduomata in rats ovariectomized during early pregnancy and delayed implantation in rats ovariectomized day 4 of pregnancy and injected dayly with oestradiol from day 8 or 9. the substance responsible seems to be progesterone or progesterone like corticoid. | 1975 | 178414 |
| tissue specific differences in the 2'-o-methylation of eukaryotic 5.8s ribosomal rna. | 1975 | 178541 | |
| [use of temperature, trypsin and biological tests for the intraspecies differentiation of local strains of aujeszky's disease virus]. | studies were carried out with 8 strains of aujeszky's disease virus using a temperature test (50 degrees c for 1 hour), a trypsin test (0.5 mg per cu. cm at 37 degrees c 1 hour), and a biologic test. the strains were isolated from the brain of dead pigs that have presumably been affected with encephalitis. they proved sensitive when studied with the temperature and the trypsin tests sharply lowering their titer. the viruses isolated from pneumonic foci in the lungs of pigs in which the disease h ... | 1975 | 179192 |
| [effect of isoproterenol on lipolysis and camp concentration in peripheral skeletal muscles of the rat]. | 1975 | 179243 | |
| an adrenergic mechanism for visual neuroregulation. | studies of the diffuse electroretinogram (erg) and evoked reponses in the optic lobe in the baby chick have shown that epinephrine produces changes in both. epinephrine produces enhancement of the a-wave and depression of the b- and d-waves in both intact and isolated eyes. in the optic lobe it produces enhancement of both components of the evoked response. the presence of epinephrine in the vertebrate retina and the optic lobe of chicks suggests that these changes may reflect the involvement of ... | 1975 | 178882 |
| role of sodium and potassium in aldosterone binding of kidney receptors in the rat. | an increase of the sodium concentration produced a diminished binding of labeled aldosterone to kidney receptors in both in vivo and in vitro conditions. the elevation of potassium level did not change the binding capacity of kidney nuclear receptors for aldosterone. hypernatraemia-induced decrease of aldosterone uptake was significant in the nuclear fraction of both medullary and cortical region of the kidney but did not show remarkable changes in the uptake of cytosol fraction. the transfer of ... | 1975 | 179799 |
| steroid production by quartered and capsular rat adrenal gland in response to haemorrhage. | 60 min after rapid bleeding (1.5--2.0 per cent of b. w.) both aldosterone and corticosterone production rate by quartered rat adrenals were found to be elevated. however, no difference was observed in the rate of aldosterone and corticosterone production by capsular adrenals of sham operated and hypovolaemic rats. corticosterone production rate by decapsulated adrenals was much more higher after haemorrhage than in the control group. the same alterations could be observed incubating adrenal tiss ... | 1975 | 179800 |
| esr determination of mn++ uptake and binding in mitochondria. | 1975 | 179871 | |
| [epidemiological aspects of cytomegalovirus infections]. | 1975 | 180573 | |
| a transovarian transmission study of marek's disease in japanese quail. | experiments were conducted to determine if transovarian transmission of the jm strain of marek's disease virus (mdv) occurs in japanese quail. in one experiment, parent quail were infected with mdv when one-day-old; in another experiment, parent quail were infected when seven weeks old. no precipitating antigen or cytopathic or infective agent was isolated from the egg yolks, embryos, newly hatched quail, or progeny quail of the infected parents. during the eight weeks observation period, the pr ... | 1975 | 180501 |
| specific and non-specific immunosuppression in chickens. | specific immunosuppression, caused by the passive transfer of immune sera, and non-specific immunosuppression, caused by acth, were investigated for possible interactions. the data confirm earlier studies which show that both types of suppression when administered independently cause reductions in humoral immune responsiveness. however, when both suppressive methods were administered simultaneously a level of suppression occurred which was not greater than that caused by either method alone. add ... | 1975 | 180505 |
| in vitro activity of clindamycin and other antimicrobials against gram-positive bacteria and hemophilus influenzae. | summary: seven antimicrobials--clindamycin, penicillin, ampicillin, cloxacillin, erythromycin, lincomycin and cephalexin--were found to have a high degree of activity in vitro against 256 isolates of gram-positive bacteria and hemophilus influenzae. clindamycin was clearly superior against staphylococci and 3.12 mug/ml or less of clindamycin inhibited all 35 isolates of h. influenzae. synergism was not demonstrated when clindamycin was tested in combination with sulfisoxazole or sulfamethoxazole ... | 1975 | 234287 |
| purine nucleoside phosphorylase from escherichia coli and salmonella typhimurium. purification and some properties. | the purine nucleoside phosphorylases from escherichia coli and from salmonella typhimurium have been purified to electrophoretic homogeneity and crystallized. comparative studies revealed that the two enzymes are very much alike. they obey simple michaelis-menten kinetics for their substrates with the exception of phosphate for which they show negative cooperativity. gel filtration on sephadex g-200 of the native enzymes revealed a molecular weight for both enzymes of 138000 plus or minus 10%. b ... | 1975 | 235429 |
| a possible mechanism of energy coupling in purine transport of saccharomyces cerevisiae. | 1975 | 235464 | |
| the role of p-hydroxylation of amphetamine in its peripheral mode of action. | desipramine completely abolished the blood pressure response to (+) amphetamine in the rat, whereas the tricyclic antidepressant iprindole did not reduce this response. since both tricyclic drugs inhibit the aromatic hydroxylation of amphetamine, these studies do not support the hypothesis that hydroxylated metabolites of amphetamine, p-hydroxyamphetamine and p-hydroxynorephedrine are essential for the peripheral sympathomimetic effects of amphetamine. | 1975 | 235613 |
| structural studies of staphylococcal protease. i. spin labelling of the active site and a comparison with other proteases. | staphylococcus aureus protease has been spin-labelled at the active-site serine residue with the monocyclic-phosphorus spin label (msl), 1-oxyl-2,2,6,6-tetramethyl-4-peperi-dinylethylphosphorofluoridate. the electron paramagnetic resonance (e.p.r.) sbectra of the protease in different buffers at various ph's have been analyzed and compared with those of trypsin, subtilisin bpn', and alpha-chymotrypsin under identical conditions. in a given buffer, the shape of e.p.r. signals of spin-labelled sta ... | 1975 | 236078 |
| immunological characterization of a diabetogenic protein from bovine adenohypophysis. | 1975 | 236123 | |
| size fractionation of double-stranded dna by precipitation with polyethylene glycol. | we show that dna molecules of differing molecular mass are separable by selective precipitation with polyethylene glycol (peg+.. higher molecular mass dna precipitates at lower peg concentrations than lower molecular mass dna. double-stranded dna can be fractionated at least in the range of 3 times 10-7 to 1 times 10-5 daltons. the effects on peg concentration, sodium chloride concentration, dna concentration, ph, divalent ions, precipitation time, and centrifugal force have been determined. the ... | 1975 | 236548 |
| perinatal infection and vaginal flora. | vaginal cultures were obtained from 1, 083 mothers on admission to the labor floor. the additional bacteriologic information gained from this survey was not sufficient to warrant continued use of the admission vaginal culture as a screening procedure. | 1975 | 236654 |
| criteria for the diagnosis of adenotonsillitis. | 1975 | 236723 | |
| microbiology of diseases of tonsils and adenoids. | 1975 | 236724 | |
| cephalothin and cephaloridine therapy for bacterial meningitis. | the efficacy of cephalothin and cephaloridine in the treatment of bacterial meningitis was evaluated from a review of 106 cases reported in the literature. fifty-nine percent of 34 patients treated with intravenous cephalothin responded suboptimally; those receiving daily doses of 12 g or more fared significantly better (p less than 0.025). in contrast, 74% of 72 patients treated with cephaloridine responded favorably; those who received concomitant intrathecal cephaloridine responded significan ... | 1975 | 237448 |
| antibacterial precipitins and autoantibodies in serum of patients with cystic fibrosis. | sera from 84 patients with cystic fibrosis, 31 patients with other respiratory diseases and 21 control persons have been investigated for the occurrence of antibacterial precipitins and autoantibodies. preciptins were studied by means of crossed immunoelectrophoresis, antinuclear factors by an indirect immunofluorescence technique and rheumatoid factors by the latex fixation slide test. a very heterogeneous antibacterial immune response was found in patients with cystic fibrosis, notably as rega ... | 1975 | 238280 |
| a new parenteral cephalosporin. sk&f 59962: in vitro and in vivo antibacterial activity and serum levels in experimental animals. | sk&f 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. when tested in vitro against gram-negative organisms, sk&f 59962 was consistently more active than cefazolin and far superior to cephalothin. this new antibiotic had activity equal to that of cephalothin against gram-positive bacteria. enterobacter species were found to be susceptible to sk&f 59962. in mouse infection studies usin ... | 1975 | 238925 |
| cross-reactive antigens and immunity to diseases caused by encapsulated bacteria. | antigenic structures may be shared among naturally occurring polymers, including proteins and polysaccharides. proteins are polymers of amino acids. cross-reactions between proteins are due to similarities in their overall shape rather than their individual amino acid components. cross-reactions have been demonstrated among proteins with similar evolutionary development and structure, such as serum albumins or immunoglobulins. polysaccharides are polymers of monosaccharides. in contrast to prote ... | 1975 | 239050 |
| [clinical evaluation of a new oral cephalosporin preparation, cephradine dry syrup, in pediatrics (author's transl)]. | 1975 | 239262 | |
| [clinical effects of lividomycin on respiratory tract infections, primarily wet cases of bronchiectasis (author's transl)]. | patients with various respiratory infections, primarily wet cases of bronchiectasis, were treated with lividomycin (lvdm) at a dose of 1 g/day for about a week. the results obtained are as follows: 1. of the 15 patients with refractory bronchiectasis who had previously been treated with various other antibiotics, 11 patients (73.3%) responded to lvdm. although there was no patient who responded to lvdm excellently, good cures were achieved in 5 pateints and fair cures in 6 patients. 2. in bronc ... | 1975 | 239263 |
| evaluation of bacteriological transport systems. | seven commercially manufactured bacteriological transport systems, including culturette, trans-cul (with stuart and amies), handiswab, securline (with amies and amies without charcoal) and culture caddy, were evaluated to determine whether these systems were capable of maintaining the viability and constant numbers of mixtures of hardy, fastidious and anaerobic organisms over 72 hours at 25c and 4c. the results of the study indicated that if specimens are maintained in transport systems at 25c t ... | 1975 | 239597 |
| studies on deoxyribonucleases from haemophilus influenzae on dna agarose affinity chromatography. two-step purification of atp-dependent deoxyribonuclease. | in a first part of this report, purification and characterization of several nucleased from lysates of haemophilus influenzae are described. the enzymes bind to dna with agarose columns and are removed by elution with phosphate buffer. among the considered enzymes, the exonucleases 1 and 3, and endonuclease, a dna polymerase and a restriction enzyme were recovered mixed by raising the phosphate concentration from 0.1 to 0.3 m, while the atp-dependent dnaase recovered well purified, by raising th ... | 1975 | 239741 |
| activity of doxycycline against respiratory pathogens. | 149 patients were admitted from the brussels area to the multi-centre pan european trial of doxycycline in respiratory tract infections. of these, 40 satisfied the strict criteria for detailed bacteriological study with positive culture of a known pathogen before treatment and bacteriological follow-up after treatment. the pathogens were beta-haemolytic streptococcus, group a (29 cases), pneumococcus (6 cases) and haemophilus influenzae (6 cases); in one case, the pneumococcus and h. influenzae ... | 1975 | 239836 |
| doxycycline in respiratory tract infections. a review of a multi-centre trial. | a total of 256 patients were admitted in germany into a pan-european multi centre trial of doxycycline in the treatment of infections of the respiratory tract. the diagnoses showed a preponderance of lower respiratory tract infections compared with other european countries, due largely to the fact that the participating physicians were pulmonary or internal medicine specialists. doxycycline was given in a dose of 200 mg initially followed by 100 mg daily for 5-10 days (only the occasional patien ... | 1975 | 239837 |
| uterine secretion during the sexual cycle in the rat and its capacity to disperse corona cells in vitro. | it was found that closure of the uterus disturbed the first 2 cycles after the operation; thereafter the normal cycle was resumed. the quantity of uterine fluid was increased at pro-oestrus and oestrus and reduced at met-oestrus and di-oestrus. slight inverse changes in viscosity were observed. there was no significant difference in the ph. the corona-cell dispersing factor seems to be an oestrogen-dependent constituent of uterine secretion. | 1975 | 239858 |
| comparative inhibitory activity of bl-s640 and two other cephalosporins. | in vitro antibacterial activity of bl-s640 was compared to that of cephalothin and cephalexin against gram-negative and gram-positive bacteria isolated from clinical specimens. bl-s640 demonstrated the best activity on nearly all microbial species studied, except for haemophilus influenzae and diplococcus pneumoniae against which cephalothin was slightly more active. | 1975 | 239917 |
| [chemotherapy of purulent meningitis in children (author's transl)]. | purulent meningitis in patients admitted to the pediatric department of kyoto university hospital and affiliated institutions from 1951 through 1973 were studied with emphasis on the kinds of the causative organisms and the susceptibility of these organisms to antibiotics. the findings in this study have served to help select antibiotics most likely to be effective against this disease. the overall incidence of purulent meningitis was 0.68%. this figure decreased little throughout the period. as ... | 1975 | 240048 |
| acute suppurative otitis media. | 1975 | 240150 |