Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| thyroid function during pregnancy in women with past graves' disease. | graves' disease and thyroid dysfunction during pregnancy can lead to maternal and fetal complications. no information is available on thyroid function in women with a past history of graves' disease. we compared free t3, free t4 and tsh in a group of pregnant women with a history of resolved graves' disease requiring no current treatment (n= 34) and in a group of pregnant controls (n= 102). we found no significant differences in the levels of these hormones between the two groups. women with a p ... | 2005 | 16225580 |
| new thyroxine treatment in older adults beginning lithium therapy: implications for clinical practice. | the authors sought to determine the incidence of lithium-induced hypothyroidism in a population-based cohort of older adults beginning lithium therapy and thereby to inform clinical guidelines on the frequency of monitoring necessary in this group. | 2005 | 15845755 |
| a case of stunning of lung and bone metastases of papillary thyroid cancer after a therapeutic dose (3.7 gbq) of 131i and review of the literature: implications for sequential treatments. | thyroid stunning is usually defined as the inhibition or suppression of iodide trapping by remnant thyroid tissue or by functioning metastases following a diagnostic dose of 131i. the risk of stunning increases progressively with larger doses. because the threshold above which this effect occurs in thyroid remnants seems to be between 37 mbq and 111 mbq of 131i, therapeutic 131i doses of 3.7 gbq may cause stunning. we describe stunning of papillary thyroid cancer lung and bone metastases after a ... | 2005 | 15845937 |
| monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry. | we have used native mass spectrometry to analyze macromolecular complexes involved in the chaperonin-assisted refolding of gp23, the major capsid protein of bacteriophage t4. adapting the instrumental methods allowed us to monitor all intermediate complexes involved in the chaperonin folding cycle. we found that groel can bind up to two unfolded gp23 substrate molecules. notably, when groel is in complex with the cochaperonin gp31, it binds exclusively one gp23. we also demonstrated that the fol ... | 2005 | 15846365 |
| why to start the concomitant boost in accelerated radiotherapy for advanced laryngeal cancer in week 3. | we analyzed toxicity and the local control rates for advanced laryngeal cancer, treated with two accelerated fractionation schedules. the main difference between the schedules was the onset of the concomitant boost, in week 3 or week 4. overall treatment time and total dose were equivalent. | 2005 | 15850903 |
| dual mechanisms whereby a broken rna end assists the catalysis of its repair by t4 rna ligase 2. | t4 rna ligase 2 (rnl2) efficiently seals 3'-oh/5'-po4 rna nicks via three nucleotidyl transfer steps. here we show that the terminal 3'-oh at the nick accelerates the second step of the ligase pathway (adenylylation of the 5'-po4 strand) by a factor of 1000, even though the 3'-oh is not chemically transformed during the reaction. also, the terminal 2'-oh at the nick accelerates the third step (attack of the 3'-oh on the 5'-adenylated strand to form a phosphodiester) by a factor of 25-35, even th ... | 2005 | 15851476 |
| is the vascular system a main target for thyroid hormones? from molecular and biochemical findings to clinical perspectives. | the cardiovascular system is an important target for thyroid hormones (ths). until recently, our understanding of the biological role of ths has been largely based on a catalog of effects observed in excess or deficiency of ths. in the last decades, however, some important progress has been done in defining the molecular and biochemical basis of thyroid hormone action at the cellular and nuclear level. most of the molecular and cellular mechanisms responsible for the effects of ths on the heart ... | 2005 | 15853633 |
| the effect of combination therapy with propylthiouracil and cholestyramine in the treatment of graves' hyperthyroidism. | the study aims to evaluate the efficacy of combination therapy with propylthiouracil (ptu) and cholestyramine in the treatment of graves' hyperthyroidism. | 2005 | 15853819 |
| resection of locally advanced (t4) non-small cell lung cancer with cardiopulmonary bypass. | resection of t4 non-small cell lung cancer (nsclc) on cardiopulmonary bypass (cpb) has rarely been reported in the literature. hence, we have reviewed our experience in the role of cpb for the surgical treatment of locally advanced nsclc. | 2005 | 15854956 |
| reduced tumor vessel density and high expression of glucose transporter 1 suggest tumor hypoxia of squamous cell carcinoma of the esophagus surviving after radiotherapy. | squamous cell carcinoma of the esophagus (escc) is radiosensitive; however, surgeons frequently encounter escc that survives radiotherapy to grow more rapidly and invasively. this alteration of tumor behavior may result from tumor hypoxia induced by radiotherapy. | 2005 | 15855926 |
| multilevel vertebral hemangiomas: two episodes of spinal cord compression at separate levels 10 years apart. | this case report presents a 66-year-old woman with multiple vertebral hemangiomas causing spinal cord compression at different levels with a long symptom-free interval between episodes of compression. she presented with back pain and progressive weakness and numbness in her lower limbs for 3 months. ten years earlier, she had had a symptomatic t4 vertebral hemangioma operated successfully, and had made a full recovery. magnetic resonance imaging (mri) of the thoracic and lumbar spine revealed mu ... | 2005 | 15856339 |
| [investigation of periodic distributions of amino acids in the sequences of fiber proteins of bacteriophage t4]. | sequences of amino acids of some fiber proteins may have a periodic structure. to analyze this periodicity fourier transform of a mathematical image of symbolic sequence of amino acids in a protein is sometimes used. in this work we employed one (out of few possible) particular way of doing fourier transform as the most straightforward and optimal. employing this optimal fourier transform method we analyzed periodicity of fiber proteins in bacteriophage t4. as a result we managed to confirm that ... | 2005 | 15856956 |
| dissociation of clinical and laboratory diagnosis in hypothyroidism. | to assess the significance of clinical versus biochemical diagnosis of hypothyroidism using a clinical scoring index and optimize the therapeutic dose of levothyroxine in indian patients. | 2005 | 15857005 |
| orthodontic treatment in a patient with papillon-lefèvre syndrome. | report of a combined periodontal and orthodontic treatment in a patient with papillon-lefevre syndrome (pls). | 2005 | 15857107 |
| neonatal screening for congenital hypothyroidism in west black sea area, turkey. | the aim of this study was to investigate the incidence of congenital hypothyroidism (ch) in the west black sea area, a mild-to-moderate iodine deficient area in turkey. neonatal screening for ch was performed using blood specimens collected onto filter paper. thyrotropin [thyroid-stimulating hormone (tsh)] was measured by radioimmunoassay, and a value >20 microu/ml was considered as cut-off point for re-examining. venous serum was obtained to measure tsh, thyroxin (t4), free t4 (ft4) and thyrogl ... | 2005 | 15857333 |
| whole plasmid mutagenic pcr for directed protein evolution. | protein function can be engineered through iterated cycles of random mutagenesis and screening (directed evolution). optimization of protein expression is essential for the development of sensitive and precise high throughput assays. here we optimize the performance of a plasmid-borne escherichia coli lacz gene in two rounds of directed evolution. first, its promoter was "randomized" by whole plasmid polymerase chain reaction (pcr) and intra-molecular self-ligation. a genetically stable constitu ... | 2005 | 15857786 |
| screening for thyroid disease in pregnancy. | although gestational hyperthyroidism is uncommon (0.2%), hypothyroidism (autoimmune disease or suboptimal iodine intake) occurs in 2.5% of women and is predictive of reduced neonatal and child neuropsychological development and maternal obstetric complications. postpartum thyroid dysfunction (pptd) occurs in 5-9% of women and is associated with antithyroid peroxidase antibodies (antitpoab) in 10% of women in early pregnancy. therefore, screening for thyroid dysfunction in pregnancy should be con ... | 2005 | 15858112 |
| herbicide-induced changes in charge recombination and redox potential of q(a) in the t4 mutant of blastochloris viridis. | to gain new insights into the function of photosystem ii (psii) herbicides dcmu (a urea herbicide) and bromoxynil (a phenolic herbicide), we have studied their effects in a better understood system, the bacterial photosynthetic reaction center of the terbutryn-resistant mutant t4 of blastochloris (bl.) viridis. this mutant is uniquely sensitive to these herbicides. we have used redox potentiometry and time-resolved absorption spectroscopy in the nanosecond and microsecond time scale. at room tem ... | 2005 | 15823053 |
| specific binding of poly(adp-ribose) polymerase-1 to cruciform hairpins. | poly(adp-ribose) polymerase-1 (parp-1) participates in dna cleavage and rejoining-dependent reactions, such as dna replication, recombination and repair. parp-1 is also important in transcriptional regulation, although the determinants for its binding to undamaged genomic dna have not been defined. previously, we have shown by low-resolution mapping that parp-1 may bind to the cruciform-forming regions of its own promoter. here, using dnase i and nuclease p(1) footprinting and atomic force micro ... | 2005 | 15826658 |
| thyroid disorders in hemodialysis patients in an iodine-deficient community. | there are various changes in the thyroid gland and its function in chronic renal failure (crf). these changes include lower levels of circulating thyroid hormone, altered peripheral hormone metabolism, decreased binding to carrier proteins, possible reduction in tissue hormone content, and increased iodine storage in the thyroid gland. the decrease of excretion of urinary iodine in crf increases serum inorganic iodine level and iodine content of the thyroid, which consequently enlarges the gland ... | 2005 | 15787628 |
| is the relationship between adherence behaviours and glycaemic control bi-directional at adolescence? a longitudinal cohort study. | to analyse the change in adherence to diabetes treatment and its association with metabolic control from childhood to adolescence. the tanner pubertal staging model was selected as a marker of developmental maturity. | 2005 | 15787668 |
| ibandronate produces significant, similar antifracture efficacy in north american and european women: new clinical findings from bone. | bone (oral ibandronate osteoporosis vertebral fracture trial in north america and europe) determined whether less frequent dosing of ibandronate (dose-free interval > 2 months) provided similar antifracture efficacy to daily dosing. as osteoporosis medications must be effective across different populations, an additional objective of bone was to investigate and report the effect of oral ibandronate in north american and european women, as described here. | 2005 | 15811208 |
| hypo-and hyperthyroidism affect the atp, adp and amp hydrolysis in rat hippocampal and cortical slices. | the presence of severe neurological symptoms in thyroid diseases has highlighted the importance of thyroid hormones in the normal functioning of the mature brain. since, atp is an important excitatory neurotransmitter and adenosine acts as a neuromodulatory structure inhibiting neurotransmitters release in the central nervous system (cns), the ectonucleotidase cascade that hydrolyzes atp to adenosine, is also involved in the control of brain functions. thus, we investigated the influence of hype ... | 2005 | 15811553 |
| effects of ammonium perchlorate on thyroid function in developing fathead minnows, pimephales promelas. | perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. our studies aimed to investigate the effects of concentrations of ammonium perchlorate that can occur in the environment (1, 10, and 100 mg/l) on the development of fathead ... | 2005 | 15811828 |
| overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. | this phase iii randomized study compared concurrent cisplatin-radiotherapy (crt) versus radiotherapy (rt) alone in patients with locoregionally advanced nasopharyngeal carcinoma. a total of 350 patients were randomly assigned to receive external rt alone or concurrently with cisplatin at a dosage of 40 mg/m(2) weekly. the primary endpoint was overall survival, and the median follow-up was 5.5 years. the 5-year overall survival was 58.6% (95% confidence interval [ci] = 50.9% to 66.2%) for the rt ... | 2005 | 15812080 |
| a novel homogenous assay for topoisomerase ii action and inhibition. | topoisomerase ii is the only enzyme able to cleave and religate double-stranded dna; this makes it essential for many vital functions during normal cell growth. increased expression of topoisomerase ii is a common occurrence in neoplasia, and different topoisomerase ii inhibitors have indeed been proven to be powerful anticancer drugs. for this reason, the topoisomerase ii catalytic cycle has attracted strong interest, but only a few techniques contributing to studies in this field have emerged. ... | 2005 | 15812853 |
| identification and distribution of acanthamoeba species genotypes associated with nonkeratitis infections. | acanthamoeba is a free-living protozoan genus found in a wide variety of natural habitats, including water, soil, and air. pathogenic isolates of acanthamoeba are medically relevant as the causative agent of sight- threatening acanthamoeba keratitis (ak), serious infections of other organs, and fatal granulomatous amebic encephalitis. previous work employing dna sequences of nuclear and mitochondrial small-subunit rrna genes (ssu rrna genes) determined the genotypic diversity of acanthamoeba and ... | 2005 | 15814986 |
| reappraisal of the risk of iodine-induced hyperthyroidism: an epidemiological population survey. | the occurrence of iodine-induced hyperthyroidism (iih) has been reported after iodine supplementation from clinics and hospitals, but not following an epidemiologic survey. we studied the prevalence of thyroid derangement in a population following iodine supplementation. one yr after more than 75% of the population had been consuming 40 ppm iodized salt; information regarding history of endemic goiter and iodized salt production, distribution, consumption and monitoring were collected in four ci ... | 2005 | 15816367 |
| gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade. | to test the hypothesis that gabexate mesilate, a protease inihibitor, hastens recovery from neuromuscular blockade, we examined the effect of gabexate mesilate on the recovery of vecuronium-induced neuromuscular blockade in anaesthetized patients in a double-blind, randomized fashion. | 2005 | 15816568 |
| color-doppler using contrast medium in evaluating the response to neoadjuvant treatment in patients with locally advanced breast carcinoma. | the aim of our study was to assess the color-doppler ultrasound (cdu) pattern in the analysis of neoadjuvant preoperative treatment of patients with locally advanced breast carcinoma, improvement after injection of contrast medium (levovist) and possible correlations between morphological and vascular aspects of the neoplasm and postoperative histopathological findings. | 2005 | 15816633 |
| brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in rats. | the present study was designed to investigate brain stem responses to manual acupuncture (ma) and electroacupuncture (ea) at different frequencies at pericardial p (5-6) acupoints located over the median nerve. activity of premotor sympathetic cardiovascular neurons in the rostral ventral lateral medulla (rvlm) was recorded during stimulation of visceral and somatic afferents in ventilated anesthetized rats. we stimulated either the splanchnic nerve at 2 hz (0.1-0.4 ma, 0.5 ms) or the median ner ... | 2005 | 15817715 |
| nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. | over the past few years increasing evidence has suggested the nongenomic effects of thyroid hormone, such as the activation of the signal transduction pathways and the activation of nuclear factor-kappab by the induction of oxidative stress. the present study was undertaken to investigate the effect of thyroid hormone on human polymorphonuclear leukocytes (pmnls) which are known as important sources of reactive oxygen species in the circulation. the production of superoxide anion (o2-) and the a ... | 2005 | 15817833 |
| endogenous immune response to gangliosides in patients with confined prostate cancer. | our study investigated whether endogenous igm antibodies to gangliosides occur in patients with early stages of prostate cancer (cap) patients, after defining ganglioside profiles of cap cell lines. immune and resorcinol staining detected the presence of gangliosides gm3, gm2, gd3, gd2 and gd1a but not gm1a, gd1b or gt1b in the extracts of normal prostatic epithelial cells (prec) and neoplastic androgen-insensitive (pc-3, du145) and -sensitive (lncap-fgc and lncap-fgc-10) cap cells. using a sens ... | 2005 | 15818621 |
| expression of helicobacter pylori alpa protein and its immunogenicity. | to construct a recombinant strain which expresses adhesin alpa of helicobacter pylori (h pylori) and to study the immunogenicity of adhesin alpa. | 2005 | 15818736 |
| physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam. | physostigmine was studied for its efficacy in the prevention of postanaesthetic shivering compared to nefopam and placebo. we studied 89 patients undergoing abdominal and urological surgery. the study was randomised and double-blind, the patients received physostigmine 2 mg (n = 31), nefopam 10 mg (n = 30) or saline (n = 28). haemodynamic parameters and temperature were measured at induction of anaesthesia (t0), and 5 min (t1), 15 min (t2), 30 min (t3) and 60 min (t4) after reaching the postanae ... | 2005 | 15819761 |
| dietary yeast rna supplementation reduces mortality by aeromonas hydrophila in rohu (labeo rohita l.) juveniles. | a feeding trial was conducted for 60 days to delineate the effect of dietary ribonucleic acid or chitin on haematological parameters, phagocyte respiratory burst and resistance to aeromonas hydrophila of labeo rohita juveniles. one hundred and twenty-six (avg. wt. 13.40 +/- 0.17 g) juveniles were randomly distributed in six treatment groups, each one in three replicates. six isonitrogenous (crude protein: 34.34-35.37%) and isocaloric (414-425 kcal 100 g(-1)) purified diets were prepared with dif ... | 2005 | 15820128 |
| [male breast cancer: about 123 cases collected at the institute salah-azaiz of tunis from 1979 to 1999]. | male breast cancer is rare compared to its female counterpart representing less than 1% of cancer in men. the objective of our retrospective study is to report the epidemiologic and clinical profile and to analyse the therapeutic results and prognostic factors in a tunisian population collected during a period of 20 years at a single institution. we collected from 1979 to 1999, all the histological confirmed male breast cancers treated at our institution. we analyse the following data: age, clin ... | 2005 | 15820923 |
| [prevalence of minimal thyroid deficiency (subclinical hypothyreosis) and subclinical thireotoxicosis among females of average and elderly ages who hadn't been examined before]. | adjara is a region in georgia with high level at iodine deficiency. the research has been carried out to find subclinical dysfunctions of thyroid gland in women older than 40 years whose thyroid state hadn't been examined before. from 1998 to 2004 583 women aged 40-78 had been examined. primary examination was done by different specialists. all women were tested on thyreotropic hormone (tsh) by means of immunodiagnostic unit "digiscan sd-1000" (austria). examination of thyroid gland on the unit ... | 2005 | 15821322 |
| surgical intervention for t4 lung cancer with infiltration of the thoracic aorta: are we back to the archetype of surgical thinking? | 2005 | 15821636 | |
| a comparison of the pathology of transitional cell carcinoma of the bladder and upper urinary tract. | to clarify the histopathological patterns of upper and lower urinary tract transitional cell carcinomas (tccs), as previous reports suggest that upper urinary tract tccs have a greater tendency towards high-grade disease than bladder tccs, of which most are low-grade and low-stage tumours. | 2005 | 15794784 |
| [effects of various iodin-nutritional on activity of t4 5'-and 5-deiodinase in rat brain]. | to investigate the changing of t4 5'-and 5-deiodinase within rat brain under various iodin-nutritional states. | 2005 | 15794888 |
| height, weight, igf-i, igfbp-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: effect of methylphenidate treatment. | to investigate if there are any disease-related or methylphenidate-induced aberrations in growth parameters, growth hormone insulin-like growth factor (igf)-i, igfbp-3 axis and the thyroid function tests in children with attention deficit hyperactivity disorder (adhd). | 2005 | 15795512 |
| do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations? | the toxicity of environmental chemicals such as nitrates, thiocynates, and perchlorates, some therapeutics, and dietary goitrogens can lower thyroidal iodine uptake and result in hypothyroidism and goiter. iodine sufficiency, essential for normal thyroid hormone synthesis, is critical during gestation to assure that sufficient thyroxine (t4) and iodine reach the developing fetus. spot urinary iodide (ui) measurements are used globally to indicate and monitor iodine sufficiency of populations. in ... | 2005 | 15795649 |
| the surgical management of superior sulcus tumors: a retrospective review with long-term follow-up. | we reviewed our experience with multimodality therapy for superior sulcus tumors to identify aspects of treatment that impact survival. | 2005 | 15797046 |
| spinal cord compression due to vertebral osteochondroma: report of two cases. | osteochondroma, or exostosis, is the most common of all benign bone tumors. spinal osteochondromas are uncommon but may cause neurological compromise. we report two cases of spinal cord compression by osteochondromas. one patient was a 17-year-old man with hereditary multiple exostoses who was presented with spastic paraparesis, a sensory level at t3-t4, and a pyramidal syndrome. vertebral exostosis was suspected by magnetic resonance imaging and confirmed by histological examination. surgical d ... | 2005 | 15797501 |
| removal of mismatched bases from synthetic genes by enzymatic mismatch cleavage. | the success of long polynucleotide de novo synthesis is largely dependent on the quality and purity of the oligonucleotides used. generally, the primary product of any synthesis reaction is directly cloned, and clones with correct products have to be identified. in this study, a novel strategy has been established for removing undesired sequence variants from primary gene synthesis products. single base-pair mismatches, insertions and deletions were cleaved with specific endonucleases. three dif ... | 2005 | 15800209 |
| analysis of single nucleotide incorporation reactions by capillary electrophoresis. | single nucleotide incorporation assays have been used to probe the kinetic parameters of many dna and rna polymerases. traditionally, oligonucleotide primers are 5'-(32)p labeled using t4 kinase and annealed to a complementary template with a 5' overhang. to quantify the reaction kinetics, the products of the primer extension reactions are usually separated using denaturing polyacrylamide gel electrophoresis and quantified using a phosphorimager or other method to measure radioactivity. we have ... | 2005 | 15802127 |
| transcription regulation by bacteriophage t4 asia. | bacteriophage t4 asia, a strong inhibitor of bacterial rna polymerase, was the first antisigma protein to be discovered. recent advances that made it possible to purify large amounts of this highly toxic protein led to an increased understanding of asia function and structure. in this review, we discuss how the small 10-kda asia protein plays a key role in t4 development through its ability to both inhibit and activate bacterial rna polymerase transcription. | 2005 | 15802215 |
| the p5 protein from bacteriophage phi-6 is a distant homolog of lytic transglycosylases. | peptidases are classical objects of enzymology and structural studies. however, a few protein families with experimentally characterized proteolytic activity, but unknown catalytic mechanism and three-dimensional structures, still exist. using comparative sequence analysis, we deduce spatial structure for one of such families, namely, u40, which contains just one p5 protein from bacteriophage phi-6. we show that this singleton sequence possesses conserved sequence motifs characteristic of lysozy ... | 2005 | 15802648 |
| histological evaluation of biopsies obtained from vertebral compression fractures: unsuspected myeloma and osteomalacia. | a histological evaluation of biopsies obtained from presumed osteoporotic vertebral compression fractures (vcf) to confirm possible osteomalacia after tetracycline labeling. | 2005 | 15803081 |
| the treatment of advanced sinonasal malignancies with pre-operative intra-arterial cisplatin and concurrent radiation. | malignancies of the nasal and paranasal sinuses are uncommon tumors, accounting for only 3% of all aerodigestive tract neoplasms. despite advances in surgical techniques and continued evolution of adjuvant therapies, the 5-year mortality remains unusually high at greater than 50%. in 1996, we begin utilizing a novel strategy in the treatment of advanced sinonasal carcinomas. this consisted of neoadjuvant selective intra-arterial cisplatin with concurrent radiation therapy (acronym radplat) follo ... | 2005 | 15803378 |
| identification of a novel pulmonary oedema producing toxin from indian red scorpion (mesobuthus tamulus) venom. | the experiments were conducted to identify the toxin that produces pulmonary oedema in mesobuthus tamulus (bt) envenomed animals. crude bt venom was subjected to sephadex gel filtration (g-75) and the fractions were screened for optical density (od), neurotoxicity (prolongation of compound action potential in frog sciatic nerve) and lethality. all these parameters exhibited a peak between 54-94 ml eluates. fractions of this peak were pooled (sp) and loaded on to carboxymethyl cellulose column. t ... | 2005 | 15804522 |
| anterior vocal commissure invasion in laryngeal carcinoma diagnosis. | laryngeal carcinoma involving anterior vocal commissure (avc) represents a great challenge for staging and treatment. | 2005 | 15805888 |
| force field impact and spin-probe modeling in molecular dynamics simulations of spin-labeled t4 lysozyme. | several attempts have been made to compute electron paramagnetic resonance (epr) spectra of biomolecules, using motional models or simulated trajectories to describe dynamics. ideally, the simulated trajectories should capture "fast" (picosecond) snapshots of spin-probe rotations accurately, while being lengthy enough to ensure a proper fourier integration of the time-domain signal. it is the interplay of the two criteria that poses computational challenges to the method. in this context, an ana ... | 2005 | 15806387 |
| [construction and expression of recombinant plasmid with prostate-specific membrane antigen promoter and enhancer regulating uracil phosphoribosyltransferase gene]. | to construct the recombinant expression plasmid ppsma(ep)-uprt including uprt gene that is regulated by psma(enhancer/promoter). | 2005 | 15807258 |
| prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the fremantle diabetes study. | to assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. | 2005 | 15807880 |
| thyroid hormone receptor binding to dna and t3-dependent transcriptional activation are inhibited by uremic toxins. | background: there is a substantial clinical overlap between chronic renal failure (crf) and hypothyroidism, suggesting the presence of hypothyroidism in uremic patients. although crf patients have low t3 and t4 levels with normal thyroid-stimulating hormone (tsh), they show a higher prevalence of goiter and evidence for blunted tissue responsiveness to t3 action. however, there are no studies examining whether thyroid hormone receptors (trs) play a role in thyroid hormone dysfunction in crf pati ... | 2005 | 15807894 |
| a clinical and therapeutic approach to thyrotoxicosis with thyroid-stimulating hormone suppression only. | subclinical hyperthyroidism is defined as normal serum free thyroxine (t4) and triiodothyronine (t3) concentrations and persistently suppressed thyroid stimulating hormone (tsh) concentrations. the most common cause of subclinical hyperthyroidism is the use of suppressive doses of l-thyroxine for treatment of hypothyroidism or, less commonly, diffuse nontoxic goiter or thyroid carcinoma (exogenous subclinical hyperthyroidism). endogenous subclinical hyperthyroidism may be caused by a variety of ... | 2005 | 15808130 |
| cloning and characterization of the hsp70 multigene family from silver sea bream: modulated gene expression between warm and cold temperature acclimation. | the genes encoding heat shock cognate 70 (hsc70) and inducible heat shock protein 70 (hsp70) were cloned and characterized from silver sea bream liver. upon acute heat shock (+7 degrees c), the transcript abundance of hsc70 was increased 1.7-fold whereas the transcript abundance of hsp70 increased 6.7-fold. the chronic acclimation of sea bream to cold temperature (12 degrees c) resulted in a downregulation of hsc70 and an upregulation of hsp70 in comparison to levels in sea bream kept at a warme ... | 2005 | 15809064 |
| mechanism of dna binding and localized strand separation by pur alpha and comparison with pur family member, pur beta. | pur alpha is a single-stranded (ss) dna- and rna-binding protein with three conserved signature repeats that have a specific affinity for guanosine-rich motifs. pur alpha unwinds a double-stranded oligonucleotide containing purine-rich repeats by maintaining contact with the purine-rich strand and displacing the pyrimidine-rich strand. mutational analysis indicates that arginine and aromatic residues in the repeat region of pur alpha are essential for both ss- and duplex dna binding. pur alpha b ... | 2005 | 15777841 |
| determination of the orientation of t4 lysozyme vectorially bound to a planar-supported lipid bilayer using site-directed spin labeling. | site-directed spin labeling is used to investigate the structure of adsorbed t4 lysozyme (t4l). a monolayer of t4l is prepared by tethering the protein selectively via a his-tag to the chelating headgroups (nta ni) of a planar quartz-supported lipid bilayer. this results in a vectorially oriented ensemble of proteins on the surface, which gives rise to angular-dependent electron paramagnetic resonance spectra. similar measurements of spin-labeled lipid bilayers were used to characterize the stru ... | 2005 | 15778448 |
| effects of selective visual attention in the parietal and temporal areas of the human cortex using evoked potential data. | studies of 11 young subjects addressed the analysis of evoked potentials in the parietal and temporal areas to sequential presentation of visual symbols on the left and right sides; symbols were squares and circles and were observed passively and in conditions of selective attention to target stimuli presented to the subjects in random order and requiring rapid and precise motor responses. comparison of monopolar evoked potentials in leads p3, p4, t3, t4, t5, and t6 with bipolar potentials in le ... | 2005 | 15779328 |
| thyroid hormone status in gray seal (halichoerus grypus) pups from the baltic sea and the atlantic ocean in relation to organochlorine pollutants. | marine apex predators, such as the gray seal (halichoerus grypus), are exposed to high concentrations of organochlorine (oc) compounds via biomagnification in the food web. these lipophilic pollutants are transferred from the female to her offspring during lactation, and there is particular concern for endocrine disruption in the offspring. herein we examined associations between the blubber concentrations of polychlorinated biphenyls (pcbs), dichlorodiphenyltrichloroethane (ddt) and metabolites ... | 2005 | 15779761 |
| description and initial evaluation of a xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds. | a need is recognized for the development and evaluation of bioassays for detection of thyroid system-disrupting compounds. the issue of testing for thyroid disruption can be addressed by exploiting amphibian metamorphosis as a biological model. in the present study, a test protocol for a xenopus metamorphosis assay (xema) was developed and its interlaboratory transferability was evaluated in an informal ring test with six laboratories participating. in the xema test, exposure of xenopus laevis t ... | 2005 | 15779766 |
| effects of perchlorate exposure on resting metabolism, peak metabolism, and thyroid function in the prairie vole (microtus ochrogaster). | perchlorate, the oxidizer component in most solid rocket propellant formulations, is known to inhibit the uptake of iodide into the thyroid gland, thereby reducing production of the thyroid hormones, triiodothyronine and thyroxine (t4). thyroid hormones regulate metabolism in endothermic organisms and are responsible for maintenance of homeothermic body temperatures. little is known about the effects of perchlorate on metabolic capacity. the objectives of the present study were to determine if s ... | 2005 | 15779769 |
| variables associated with recurrence in breast cancer patients-the shaukat khanum memorial experience. | from a cohort of female breast cancer patients registered at the shaukat khanum memorial cancer hospital and research center, in lahore, pakistan, during the time period extending from december 1994 to december 2002, 700 subjects who were followed up in time, were selected. those who presented with benign tumors, carcinoma in situ, or metastases were excluded from the analyses. age, tumor size, nodal status, menopause, estrogen receptor (er), and progesterone receptor (pr) status, at the time of ... | 2005 | 15780033 |
| bacteriophage t4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. | bacteriophage t4 initiates origin-dependent replication via an r-loop mechanism in vivo. during in vitro reactions, the phage-encoded gp59 stimulates loading of the replicative helicase, gp41, onto branched intermediates, including origin r-loops. however, although gp59 is essential for recombination-dependent replication from d-loops, it does not appear to be required for origin-dependent replication in vivo. in this study, we have analyzed the origin-replicative intermediates formed during inf ... | 2005 | 15781450 |
| case of prolonged alcohol withdrawal syndrome accompanied with hyperthyroidsim. | hyperthyroidism is associated with increased psychiatric morbidity. it may alter the clinical course of alcohol withdrawal syndrome. we report a 69 year old man who presented prolonged alcohol withdrawal syndrome associated with hyperthyroidism. initially, he developed typical alcohol withdrawal syndrome including tremor, disorientation, delirium and visual hallucination of small animals. thyroid function tests revealed a free triiodothyronine (t3) of 6.1 pg/dl (range, 3.0 to 5.8), a free thyrox ... | 2005 | 15782582 |
| total syntheses of amphidinolides t1 and t4 via catalytic, stereoselective, reductive macrocyclizations. | described in this work are total syntheses of amphidinolides t1 and t4 using two nickel-catalyzed reductive coupling reactions of alkynes, with an epoxide in one case (intermolecular) and with an aldehyde in another (intramolecular). the latter was used to effect a macrocyclization, form a c-c bond, and install a stereogenic center with >10:1 selectivity in both natural product syntheses. alternative approaches in which intermolecular alkyne-aldehyde reductive coupling reactions would serve to j ... | 2005 | 15783211 |
| different mitogen-mediated beta-adrenergic receptor modulation in murine t lymphocytes depending on the thyroid status. | the aim of this work was to analyze beta-adrenergic receptor (betaar) regulation of t-lymphocyte proliferation in mice according to different thyroid hormone statuses. | 2005 | 15785111 |
| intensified concurrent chemoradiotherapy with 5-fluorouracil and irinotecan as neoadjuvant treatment in patients with locally advanced rectal cancer. | this study aimed to evaluate the feasibility and efficacy of neoadjuvant chemoradiotherapy intensified with irinotecan in patients with locally advanced rectal cancer. eligible patients had nonmetastatic disease at a locally advanced stage that made r0 resection and sphincter preservation uncertain. they received preoperative radiation over 6 weeks to 45 gy and boost of 5.4 gy and concurrent continuous infusion 5-fluorouracil 250 mg m(-2) day(-1) and weekly irinotecan 40 mg m(-2). in all, 37 pat ... | 2005 | 15785742 |
| endoscopic ultrasound for esophageal and gastroesophageal junction cancer: impact of increased use of primary neoadjuvant therapy on preoperative locoregional staging accuracy. | initial treatment of locally advanced esophageal and gastroesophageal junction (gej) malignancies for selected patients at some institutions has recently changed from surgical resection to neoadjuvant therapy. the aim of this study is to evaluate the impact of this change in treatment strategy on both the overall disease profile and locoregional endoscopic ultrasound (eus) staging accuracy for a cohort of patients managed with primary surgical resection over a 10-year period at our institution. ... | 2005 | 15773837 |
| [correlation between prevalent and incident osteoporotic vertebral fractures in beijing male elderly]. | to investigate the correlation between prevalent and incident osteoporotic vertebral fractures in beijing male elderly. | 2005 | 15774211 |
| [long-term results of different treatment modalities in 464 hypopharyngeal squamous-cell carcinoma patients]. | to present the treatment results and to identify the most effective therapeutic plan of different therapeutic modalities in patients with squamous-cell carcinoma of hypopharynnx. | 2005 | 15771800 |
| prediction of poor survival by cyclooxygenase-2 in patients with t4 nasopharyngeal cancer treated by radiation therapy: clinical and in vitro studies. | this study was undertaken to determine the status of cyclooxygenase-2 (cox-2) in nasopharyngeal cancer (npc) in taiwanese patients and its relationship to survival after radiotherapy (rt). in addition, the effect of ns-398, a potent selective cox-2 inhibitor, was tested in vitro alone and in combination with radiation on npc-bm1 human npc cells as a prelude to using this drug along with rt in the treatment of patients with npc. | 2005 | 15772955 |
| epidural ropivacaine 1% with and without sufentanil addition for caesarean section. | so far only ropivacaine concentrations of 0.5 and 0.75% have been used for caesarean section. this prospective double-blind trial evaluated the anaesthetic quality of ropivacaine 1% with and without sufentanil addition. | 2005 | 15777301 |
| efficacy of sufentanil addition to ropivacaine epidural anaesthesia for caesarean section. | this prospective double-blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective caesarean section. | 2005 | 15777302 |
| characterization of cells with proliferative activity after a brain injury. | the cellular responses to a brain injury are important steps in restoring the integrity and function of the brain. proliferating cells, such as reactive astrocytes, oligodendrocyte precursor cells and microglia remodel the injured tissue. to spatially and temporally characterize the initial cellular responses in vivo, proliferating cells were pulse-labeled with brdu soon after (the 2nd day) a cortical cryo-injury, and their fate was investigated by double labeling with an anti-brdu antibody and ... | 2005 | 15737436 |
| architecture of the bacteriophage t4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). | replication of dna requires helicase and primase activities as part of a primosome assembly. in bacteriophage t4, helicase and primase are separate polypeptides for which little structural information is available and whose mechanism of association within the primosome is not yet understood. three-dimensional structural information is provided here by means of reconstructions from electron microscopic images. structures have been calculated for complexes of each of these proteins with ssdna in t ... | 2005 | 15738414 |
| maternal thyroid hormonal status in preeclampsia. | the physiological changes in the thyroid gland during pregnancy are well understood but only a few reports provide information about thyroid function in complicated pregnancies. | 2005 | 15738611 |
| [present treatment strategies for rectal carcinoma]. | in the last ten years, considerable progress has been achieved in the treatment of rectal cancer. according to improved interdisciplinary staging, rectal carcinomas can be treated based on a stage-dependent concept: "low-risk" pt1 (g1/g2) carcinomas can be cured by local full wall excision, while "high-risk" pt1 (g3/g4) and pt2 carcinomas require transabdominal resection. in contrast, locally advanced rectal cancers in cuicc-ii/-iii stages (t3/t4 or n(+)) should receive long-term, 5-fu-based, ne ... | 2005 | 15739059 |
| clinical and molecular prognostic factors in operable laryngeal cancer. | many factors affect the prognosis in operable laryngeal squamous cell carcinoma (lscc). many clinical factors have been implicated in tumor recurrence and poor survival of the patients. the aim of the present study is to investigate the demographic, clinical and histological characteristics as prognostic factors. moreover, our aim is to analyze the role of modern molecular biomarkers in the prognosis of patients with lscc. one hundred patients with operable laryngeal carcinoma underwent surgery ... | 2005 | 15739081 |
| dimeric dutpases, hise, and mazg belong to a new superfamily of all-alpha ntp pyrophosphohydrolases with potential "house-cleaning" functions. | structure-guided analysis of the new dimeric dutpase family revealed its sequence relationship to the phage t4 dctpase, phosphoribosyl-atp pyrophosphatase hise, ntp pyrophosphatase mazg, and several uncharacterized protein families, including the human protein xtp3tpa (rs21-c6), which is overexpressed in embryonic and cancer cells. comparison with the recently determined structure of a mazg-like protein from sulfolobus solfataricus supported the unification of these enzymes in one superfamily of ... | 2005 | 15740738 |
| mechanistic studies of the t4 dna (gp41) replication helicase: functional interactions of the c-terminal tails of the helicase subunits with the t4 (gp59) helicase loader protein. | we compare the activities of the wild-type (gp41wt) and mutant (gp41delta c20) forms of the bacteriophage t4 replication helicase. in the gp41delta c20 mutant the helicase subunits have been genetically truncated to remove the 20 residue c-terminal tail peptide domains present in the wild-type enzyme. here, we examine the interactions of these helicase forms with the t4 gp59 helicase loader and the gp32 single-stranded dna binding proteins, both of which are physically and functionally coupled w ... | 2005 | 15740739 |
| leptin treatment during lactation increases transfer of iodine through the milk. | we have previously shown that protein restriction during lactation is associated with changes in iodine secretion into the milk and that a pup's serum leptin concentration was increased at the end of lactation. so, here we evaluate whether leptin treatment during lactation affects iodine transfer through the milk to the pups. lactating rats were divided into two groups: the leptin (lep) group, single injected with recombinant rat leptin (8 microg/100g of body weight, daily for 3 consecutive days ... | 2005 | 15741047 |
| [etiological assessment of hyperthyrotropinemia in children with down's syndrome]. | to study the prevalence of increased tsh level and its probable cause in children with down's syndrome treated at policlínica antônio cândido. | 2005 | 15742091 |
| supradose intra-arterial cisplatin and concurrent radiation therapy for the treatment of stage iv head and neck squamous cell carcinoma is feasible and efficacious in a multi-institutional setting: results of radiation therapy oncology group trial 9615. | to determine the feasibility of high-dose intra-arterial (ia) cisplatin and concurrent radiation therapy (rt) for head and neck squamous cell carcinoma in the multi-institutional setting (multi-radplat). | 2005 | 15735120 |
| the outcome of radical surgery and postoperative radiotherapy for squamous carcinoma of the temporal bone. | the objective was to analyze the clinical data and outcome of all the patients treated surgically for squamous carcinoma of the temporal bone in a tertiary referral department of skull base surgery over a 20-year period. | 2005 | 15689763 |
| effect of thyroxine on abnormal pancreatic proteomes of the hypothyroid rdw rat. | a mutation in the thyroglobulin (tg) gene is the primary cause of hereditary dwarfism and hypothyroidism in the rdw rat. despite the tg mutation that causes a tg shortage, rdw rats survive. the present study examines the influences of this condition on the pancreatic proteome. normal control (group 1; n = 19) and rdw rats that did not receive l-thyroxine (t4) (group 2; n = 27) were sacrificed from 4 to 56 weeks after birth. the rdw rats were supplemented either with daily intraperitoneal injecti ... | 2005 | 15712237 |
| physiological and genetic responses of european eel (anguilla anguilla l.) to short-term chromium or copper exposure-influence of preexposure to a pah-like compound. | anguilla anguilla l. (european eel) was exposed for 24 h to chromium (cr-100 microm and 1 mm) or copper (cu-1 and 2.5 microm), with or without a 24-h preexposure to beta-naphthoflavone (bnf-2.7 microm), a polycyclic aromatic hydrocarbon (pah)-like compound, simulating sequential exposure to pahs and heavy metals. plasma cortisol, thyroid-stimulating hormone (tsh), free triiodothyronine (t3), and free thyroxine (t4) were determined in order to assess the effects on endocrine function. plasma gluc ... | 2005 | 15712285 |
| psychosocial factors involved in delayed consultation by patients with head and neck cancer. | in the north of france, a delay in primary consultation has been noted among patients with head and neck cancer. this group is often correlated with lower socioeconomic status and a lack of medical information. therefore, the choice to seek consultation is often influenced by symptoms such as pain and change in the size of tumors in the neck. we studied this delay in seeking consultation, focusing on psychosocial variables such as professional and social background, the involvement of a spouse/p ... | 2005 | 15712292 |
| recombinant human thyrotropin as adjuvant in the treatment of multinodular goiters with radioiodine. | the use of 131i in the treatment of multinodular goiters (mng) is well established. we evaluated the effect of 30 microci 131i (1.11 gbq) in 18 patients with mng with the aid of two injections of 0.1 mg recombinant human tsh (rhtsh), given on d 1 and 2. a dose of 30 microci 131i was given on d 3. tsh, t3, free t4, and thyroglobulin were measured on d 1, 2, 3, 5, 10, 30, 60, 90, and 180, and antithyroid antibodies were measured on d 1, 30, 90, and 180. twenty-four-hour 131i uptake measured 1-3 mo ... | 2005 | 15713700 |
| definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base. | the purpose of this study was to examine the long-term outcome of a cohort of patients with unresected base of tongue carcinoma who received interstitial brachytherapy after comprehensive external beam radiation therapy. | 2005 | 15726587 |
| survival outcome of patients with nasopharyngeal carcinoma with first local failure: a study by the hong kong nasopharyngeal carcinoma study group. | the purpose of this article is to report the overall survival (os) outcome of patients with nasopharyngeal carcinoma (npc) with local failure who received salvage treatment and to identify prognostic factors for os. | 2005 | 15726589 |
| generation of long tracts of disease-associated dna repeats. | the generation of long uninterrupted dna repeats is important for the study of repeat instability associated with several human genetic diseases, including myotonic dystrophy type 1. however, obtaining defined lengths of long repeats in vitro has been problematic. strand slippage and/or dna secondary structure formation may prevent efficient ligation. for example, a purified (ctg)140.(cag)140 repeat fragment containing 4-bp agca/tgct overhanging ends ligated poorly using t4 or escherichia coli d ... | 2005 | 15727131 |
| improvement of chronic idiopathic urticaria with l-thyroxine: a new tsh role in immune response? | the association between chronic idiopathic urticaria (ciu) and autoimmune thyroiditis (at) is known, as well as major prevalence of antithyroid antibodies in the allergical subjects and other autoimmune diseases. we have evaluated the effects of l-thyroxine on clinical symptoms of ciu in at patients suggesting the hypothesis of a new thyroid-stimulating hormone (tsh) role in immune system. | 2005 | 15727581 |
| sexual dimorphism of thyroid function in newborns with congenital hypothyroidism. | several characteristics of congenital hypothyroidism (ch) from thyroid dysgenesis (ectopy and athyreosis) are sexually dimorphic: girls are more often affected, and boys are twice more likely than girls to have absent knee epiphysis at diagnosis, an indicator of severity of ch. whether the biochemical severity of ch is sexually dimorphic is unknown. we therefore reviewed the charts of all newborns referred to our clinic from 1990 to 2004 because of a tsh greater than 15 mu/liter on newborn scree ... | 2005 | 15728201 |
| assembly of the bacteriophage t4 primosome: single-molecule and ensemble studies. | within replisomes for dna replication, the primosome is responsible for unwinding double-stranded dna and synthesizing rna primers. assembly of the bacteriophage t4 primosome on individual molecules of ssdna or forked dna (fdna) has been studied by using fret microscopy. on either dna substrate, an ordered process of assembly begins with tight 1:1 binding of ssdna-binding protein (gp32) and helicase-loading protein (gp59) to the dna. magnesium adenosine 5'-o-(3-thiotriphosphate) (mgatpgammas) me ... | 2005 | 15728347 |
| thyroxine-binding antibodies inhibit t cell recognition of a pathogenic thyroglobulin epitope. | thyroid hormone-binding (thb) abs are frequently detected in autoimmune thyroid disorders but it is unknown whether they can exert immunoregulatory effects. we report that a thb mab recognizing the 5' iodine atom of the outer phenolic ring of thyroxine (t4) can block t cell recognition of the pathogenic thyroglobulin (tg) peptide (2549-2560) that contains t4 at aa position 2553 (t4(2553)). following peptide binding to the mhc groove, the thb mab inhibited activation of the a(k)-restricted, t4(25 ... | 2005 | 15728526 |
| gender differences in growth hormone response to exercise before and after rhgh administration and the effect of rhgh on the hormone profile of fit normal adults. | exercise is a potent physiological stimulus of gh secretion. we hypothesized that exogenous recombinant human growth hormone (rhgh) administration through an increase in gh and igf-i levels would blunt the gh response to exercise. the aim of the study was to examine and compare the impact of rhgh on the exercise-induced gh response in healthy normal men and women. | 2005 | 15730413 |