Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [construction of eukaryotic expression vector expressing hepatitis c virus ns5b and egfp fusion protein and establishment of stable transfected hepg2 cell line]. | to construct a eukaryotic expression vector for expressing hepatitis c virus (hcv) recombinant ns5b-egfp fusion protein and obtain a stable transfected hepg2 cell line. | 2005 | 16201473 |
| hemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia in coronary artery bypass surgery. | the purpose of this study was to compare the hemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia during coronary artery bypass surgery. | 2005 | 16202892 |
| a prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery. | the purpose of this study was to test the hypothesis that after thoracic surgery, the supplementation of a low-dose thoracic epidural (ed) bupivacaine (0.125%) infusion by intravenous (iv) dexmedetomidine decreases analgesic requirement without causing respiratory depression. the primary endpoint was the need for additional ed bupivacaine administered through patient-controlled epidural analgesia (pcea). secondary endpoints included the requirement for supplemental opioids and the impact of dexm ... | 2005 | 16202898 |
| decrease of functional coupling between left and right auditory cortices during dichotic listening: an electroencephalography study. | the present study focused on functional coupling between human bilateral auditory cortices and on possible influence of right over left auditory cortex during dichotic listening of complex non-verbal tones having near (competing) compared with distant non-competing fundamental frequencies. it was hypothesized that dichotic stimulation with competing tones would induce a decline of functional coupling between the two auditory cortices, as revealed by a decrease of electroencephalography coherence ... | 2005 | 16203106 |
| circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors. | it has been claimed that with the use of the trh test and knowledge of the nocturnal tsh surge, the diagnosis of so-called hidden central hypothyroidism might be uncovered in a substantial proportion of euthyroid cranially irradiated children. | 2005 | 16204362 |
| ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-t4ac complex at 2.2 angstrom resolution. | the crystal structure of the complex of human transthyretin (httr) with 3,3',5,5'-tetraiodothyroacetic acid (t4ac) has been determined to 2.2 angstrom resolution. the complex crystallizes in the orthorhombic space group p2(1)2(1)2, with unit-cell parameters a = 43.46, b = 85.85, c = 65.44 angstrom. the structure was refined to r = 17.3% and r(free) = 21.9% for reflections without any sigma-cutoff. t4ac is bound in both the forward and the reverse mode in the two binding sites of httr. in the for ... | 2005 | 16204882 |
| factors influencing the synonymous codon and amino acid usage bias in at-rich pseudomonas aeruginosa phage phikz. | to reveal how the at-rich genome of bacteriophage phikz has been shaped in order to carry out its growth in the gc-rich host pseudomonas aeruginosa, synonymous codon and amino acid usage bias of phikz was investigated and the data were compared with that of p. aeruginosa. it was found that synonymous codon and amino acid usage of phikz was distinct from that of p. aeruginosa. in contrast to p. aeruginosa, the third codon position of the synonymous codons of phikz carries mostly a or t base; codo ... | 2005 | 16143818 |
| [surgical therapy of subglottic carcinoma]. | to analyze the clinical characteristics, surgical procedures and correlated prognostic factors of the cases with subglottic carcinoma; to seek for the optimal surgical treatment for the patients suffering from subglottic carcinoma. | 2005 | 16144333 |
| [supracricoid partial laryngectomy for the treatment of laryngeal cancer]. | to evaluate the oncological and functional outcomes in patients undergoing supracricoid partial laryngectomy (scpl). | 2005 | 16144335 |
| polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy. | some patients on levothyroxine replacement display significant impairment in psychological well-being, compared with sex- and age-matched controls. levothyroxine-treated patients can be assumed to derive t3 exclusively from deiodination of t4, which, in the central nervous system, is regulated by type ii deiodinase (dii). | 2005 | 16144953 |
| effect of sub-acute oral cyanide administration in rats: protective efficacy of alpha-ketoglutarate and sodium thiosulfate. | chronic toxicity of cyanide in humans and animals has been previously described. alpha-ketoglutarate (alpha-kg) and sodium thiosulfate (sts) are known to confer remarkable protection against acute cyanide poisoning in rodents. their efficacy against sub-acute or chronic cyanide exposure is not known. the objective of the present study was to assess the sub-acute toxicity of potassium cyanide (kcn) in female rats following oral administration of 7.0 mg/kg (0.5 ld50) for 14 d. the effect of alpha- ... | 2005 | 16154552 |
| synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. | mechanisms regulating materno-fetal transfer of thyroid hormone are not well understood. modulation of trophoblast type 3 iodothyronine deiodinase (d3) may play an important role. | 2005 | 16159939 |
| a new concurrent chemotherapy with vinorelbine and mitomycin c in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. | the purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin c in combination with accelerated radiotherapy (rt) in patients with locally advanced cancer of the head and neck. | 2005 | 16160398 |
| the incidence of sheehan's syndrome after obstetric hemorrhage. | to estimate the incidence of sheehan's syndrome in a well-described cohort of patients with obstetric hemorrhage. | 2005 | 16213852 |
| [a spinal cord injury caused by a migrating kirschner wire following osteosynthesis of the clavicle: a case review]. | a case of penetrating spinal cord injury in 47 year old man, caused by migration of kirschner wire is presented. the patient underwent the operation for acromioclavicular luxation 2 years ago--osteosynthesis with the use of 2 kirschner wires. admission with clinical symptoms of severe paraparesis of lower limbs. ct proved penetration of the first k-wire transversally through spinal cord in the level c7/t1, the second one stopped in the right transversal foramen t4. emergent operation--extraction ... | 2005 | 16164089 |
| correlation of magnetic resonance imaging and pathologic size of infiltrating lobular carcinoma of the breast. | determining the extent of infiltrating lobular carcinoma (ilca) in the breast is difficult. this study was designed to determine if the size of ilca on magnetic resonance imaging (mri) correlated with final pathology. | 2005 | 16164936 |
| pituitary hyperplasia secondary to primary hypothyroidism: a case report and review of the literature. | pituitary hyperplasia secondary to primary hypothyroidism has been reported in the literature in both adults and children. we report a case of a young woman who was diagnosed with hypothyroidism in her teenage years. despite frequent follow-up, her tsh levels remained greater than 100 miu/ml. a few years later, pituitary enlargement was found on an mri at a time when her tsh was 177 miu/ml and her free t4 was 0.2 ng/dl. observed administration of 600 mcg of l-thyroxine was performed to determine ... | 2005 | 16195776 |
| oral and pharyngeal cancer: analysis of patient delay at different tumor stages. | the aim of this study was to examine which factors are related to patient delay in a cohort of consecutive patients with pharyngeal cancer and oral cancer and to determine whether the different stages of patient delay (ie, appraisal, illness, behavioral, and scheduling) were related to different tumor stages. | 2005 | 16206281 |
| [sedation and study of hormone dynamics in patients with severe brain injury during early postoperative period]. | the paper presents the results of an investigation of the effect of sodium oxybutyrate, thiopental sodium, and propofol on the blood levels of cortisol, acth, tth, t4 and t3 in patients with severe brain injury who have received artificial ventilation. the investigations showed that laboratory signs of the low t3-syndrome appeared by postoperative day 3 in all the patients. in patients receiving propofol, the manifestations of this syndrome were less pronounced and the parameters became normal m ... | 2005 | 16206588 |
| radiation-induced spinal cord cavernous malformation. case report. | the authors report a case of a 16-year-old girl who presented with progressive gait difficulty 8 years after undergoing spinal radiation therapy for spinal astrocytoma. magnetic resonance imaging revealed intramedullary multicentric cavity formation in the t4-10 area. extensive subtotal resection was performed and a pathological examination of the excised tissue demonstrated cavernous malformation with radiation-induced degeneration in the surrounding vessels. this is believed to be the third ca ... | 2005 | 16206743 |
| locally advanced differentiated thyroid carcinoma: a 35-year mono-institutional experience in 280 patients. | debate exists in the literature about the optimal treatment to be adopted in patients with locally advanced differentiated thyroid carcinoma. we aimed to better define the most appropriate diagnostic and therapeutic protocol for this type of tumour. | 2005 | 16208173 |
| as fast and selective as enzymatic ligations: unpaired nucleobases increase the selectivity of dna-controlled native chemical pna ligation. | dna-controlled reactions offer interesting opportunities in biological, chemical, and nanosciences. in practical applications, such as in dna sequence analysis, the sequence fidelity of the chemical-ligation reaction is of central importance. we present a ligation reaction that is as fast as and much more selective than enzymatic t4 ligase-mediated oligonucleotide ligations. the selectivity was higher than 3000-fold in discriminating matched from singly mismatched dna templates. it is demonstrat ... | 2005 | 16208732 |
| addendum: site-directed mutagenesis using pfu dna polymerase and t4 dna ligase. | 2005 | 16208829 | |
| [spinal cord and vertebral column injuries in children]. | analysis of main factors of spinal cord and vertebral column injuries in our environment. | 2005 | 16209374 |
| microsatellite instability and proliferating activity in sinonasal carcinoma: molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma. | sinonasal carcinomas arise from the respiratory epithelium that lines the nasal and paranasal cavities, and are histologically composed of either squamous or cylindrical cell carcinoma. however, molecular analysis with the purpose of distinguishing sinonasal carcinomas from other head and neck squamous cell carcinomas (hnsccs), which arise from squamous epithelium, has been limited. moreover, a wide range of frequency of microsatellite instability (msi) in hnscc has been reported. using high-res ... | 2005 | 16211276 |
| chemoradiotherapy for t3 and t4 squamous cell carcinoma of the esophagus using low-dose fp and radiation: a preliminary report. | we conducted this study to evaluate the clinical significance of preoperative concurrent chemoradiotherapy (crt) followed by esophagectomy in the management of t3 and t4 esophageal cancer. thirty patients with squamous cell carcinoma of the esophagus received crt followed by surgery. preoperative crt consisted of 5-fluorouracil (500 mg/m(2) by 24 h infusion for 5 days), cisplatin (15 mg/m(2) on days 1-5), and concurrent radiotherapy (a total dose of 40 gy delivered in daily fractions of 2 gy, 5 ... | 2005 | 16211282 |
| which is responsible for the haemodynamic response due to laryngoscopy and endotracheal intubation? catecholamines, vasopressin or angiotensin? | we have investigated the concentrations of epinephrine, norepinephrine, vasopressin and angiotensin converting enzyme activity to explore the role of these mediators in the neuroendocrine response to laryngoscopy and tracheal intubation. | 2005 | 16211744 |
| effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men. | megestrol acetate (ma) is a synthetic progestin commonly used to promote weight gain in malnourished older individuals. in small studies, ma administration has been associated with reduced serum cortisol concentrations in patients with cancer or aids. the impact of ma on the pituitary secretion of adrenocorticotropic hormone (acth) and other hormones is unclear, and the prevalence and extent of hypocortisolemia in older individuals after ma treatment is unknown. a randomized, placebo-controlled ... | 2005 | 16257818 |
| segh and hef: two novel homing endonucleases whose genes replace the mobc and mobe genes in several t4-related phages. | t4 contains two groups of genes with similarity to homing endonucleases, the seg-genes (similarity to endonucleases encoded by group i introns) containing giy-yig motifs and the mob-genes (similarity to mobile endonucleases) containing h-n-h motifs. the four seg-genes characterized to date encode homing endonucleases with cleavage sites close to their respective gene loci while none of the mob-genes have been shown to cleave dna. of 18 phages screened, only t4 was found to have mobc while mobe g ... | 2005 | 16257983 |
| opposite roles of the dmd gene in the control of rnase e and rnase ls activities. | when the dmd gene of bacteriophage t4 is defective, expression of middle genes starts normally but drops abruptly. however, the residual expression of middle genes at late stages continues at a higher rate in cells infected with a dmd mutant than with the wild type. in order to understand the complex effects of the dmd gene, we followed changes in the quantity of mrna from a middle gene, uvsy. the uvsy mrna was degraded rapidly by rnase ls at middle stages but stabilized at late stages, suggesti ... | 2005 | 16284417 |
| ratio of serum free triiodothyronine to free thyroxine in graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis. | the serum t3 to t4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from graves' thyrotoxicosis. however, the usefulness of the serum free t3 (ft3) to free t4 (ft4) ratio is controversial. we therefore systematically evaluated the usefulness of this ratio, based on measurements made using two widely available commercial kits in two hospitals. eighty-two untreated patients with thyrotoxicosis (48 patients with graves' disease and 34 patients with painless thyroid ... | 2005 | 16284430 |
| pedicle screw fixation of the thoracic spine: an in vitro biomechanical study on different configurations. | an in vitro biomechanical study of different pedicle screw configuration usage on the thoracic spine using a cadaveric model. | 2005 | 16284591 |
| the validity of lenke criteria for defining structural proximal thoracic curves in patients with adolescent idiopathic scoliosis. | retrospective series. | 2005 | 16284594 |
| a randomized phase iii trial of post-operative adjuvant oral fluoropyrimidine versus sequential paclitaxel/oral fluoropyrimidine; and uft versus s1 for t3/t4 gastric carcinoma: the stomach cancer adjuvant multi-institutional trial group (samit) trial. | paclitaxel, s1 and their combined sequential administration is proposed to be examined installing uft as an active control of adjuvant chemotherapy for curatively resected t3-4 gastric cancer in a multicenter phase iii trial. the primary endpoint is disease-free survival and the secondary endpoints are incidence of adverse events, overall survival and compliance. the sample size is 370 per treatment arm (1480 in total) for two hypotheses of the superiority of sequential use of paclitaxel followe ... | 2005 | 16275676 |
| preoperative chemotherapy and radiation therapy for squamous cell carcinoma of the maxillary sinus. | this study was undertaken to assess the prognostic factors for the management of squamous cell carcinoma (scc) of the maxillary sinus, who received preoperative chemotherapy and radiation therapy (rt). we also elucidated the appropriate sequence of chemotherapy. | 2005 | 16275677 |
| seroreactivity to a-type retrovirus proteins in a subset of cats with hyperthyroidism. | the thyroid gland is afflicted in several endocrine, autoimmune, and malignant diseases. previous studies detected immunoreactivity against proteins of a human intracisternal a-type retroviral particle type-i (hiap-i) in serum samples from the majority of patients with graves' disease, an autoimmune disease of the thyroid that can also affect other organs, most prominently the eyes. to determine whether hyperthyroid animals might provide a model for the retroviral involvement in thyroid autoimmu ... | 2005 | 16276511 |
| evaluation of right and left ventricular function using pulsed-wave tissue doppler echocardiography in patients with subclinical hypothyroidism. | previous studies showed that subclinical hypothyroidism (sh) was associated with cardiovascular disorders, such as endothelial dysfunction, atherosclerosis and myocardial dysfunction. only one study investigated left ventricular (lv) function using pulsed tissue doppler echocardiography (tde) in patients with sh. however, no study has used this technique in the identification of right ventricular (rv) function in these patients. we aimed to investigate the effect of sh on rv and lv function usin ... | 2005 | 16277166 |
| prevalence of goiter among schoolchildren from gorgan, iran, a decade after national iodine supplementation: association with age, gender, and thyroperoxidase antibodies. | one decade after universal salt iodization in iran, goiter prevalence, urinary iodine concentration (uic) and thyroperoxidase antibody (tpoab) values were assessed among schoolchildren in gorgan, iran. | 2005 | 16277169 |
| synthesis of 2'-c-difluoromethylribonucleosides and their enzymatic incorporation into oligonucleotides. | [chemical reaction: see text] nucleosides bearing a branched ribose have significant promise as therapeutic agents and biotechnological and biochemical tools. here we describe synthetic entry into a new subclass of these analogues, 2'-c-beta-difluoromethylribonucleosides. we constructed the glycosylating agent 4 in three steps from 1,3,5-tri-o-benzoyl-alpha-d-ribofuranose 1. the key steps included nucleophilic addition of difluoromethyl phenyl sulfone to 2-ketoribose 2 followed by mild and effic ... | 2005 | 16277309 |
| thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemia. | data on the effect of maternal malnutrition and/or anemia on thyroid hormone regulation in human fetuses are scarce, and would be of great importance in examining the relevance of barker's hypothesis, which proposes adaptation of fetuses to undernutrition leading to permanent metabolic and endocrine changes that form the basis of adult diseases. to examine the quantitative variations in thyroid hormone profile of neonates born to malnourished and/or anemic mothers, we quantitated the t3, t4, rt3 ... | 2005 | 16278787 |
| factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. | basal metabolic rate (bmr) is the largest component of daily energy demand in western societies. previous studies indicated that bmr is highly variable, but the cause of this variation is disputed. all studies agree that variation in fat-free mass (ffm) plays a major role, but effects of fat mass (fm), age, sex, and the hormones leptin, triiodothyrionine (t3), and thyroxine (t4) remain uncertain. | 2005 | 16280423 |
| cystoprostatectomy for effective palliation of symptomatic bladder invasion by prostate cancer. | we evaluated the palliative effect of cystoprostatectomy (cp) for palliating pelvic symptoms in patients with bladder invasion by prostate cancer. | 2005 | 16280761 |
| anti-thyroid methimazole in an acidosis-induced retinopathy rat model of retinopathy of prematurity. | methimazole (mmi), an anti-thyroid drug known to reduce serum levels of l-thyroxine (t4) and insulin-like growth factor-1 (igf-1), has been previously reported to increase the incidence of neovascularization (nv) in an oxygen-induced retinopathy (oir) model of retinopathy of prematurity (rop) in rats. we investigated the effect of mmi on the incidence and severity of nv in a non-oxygen-induced model of rop, acidosis-induced retinopathy (air). | 2005 | 16280976 |
| [changes of the thyroid hormone status in children with cerebral palsy and other neurological pathology]. | content of thyroid hormones (t3 and t4) and thyrotropin (ttg) hormone in blood plasma has been studied in 142 children with neurological pathology (cerebral palsy, perinatal cns lesion). in most cases, there was a significant increase of t3 and t4 and reduction of ttg as compared to control group of healthy children. the changes of thyroid hormones content depended on the patient's age and severity of a pathological condition. a mother pregnancy course impacted on the hormones level. the content ... | 2005 | 16281373 |
| [concurrent chemoradiotherapy for advanced hypopharyngeal cancer]. | chemotherapy has been shown to be most effective when delivered concurrently with radiation for the patients with advanced stage tumors. we conducted a concurrent chemoradiation using systemic infusion of cisplatin (cddp) and 5-fluorouracil (5-fu). | 2005 | 16285613 |
| a case control study on psychiatric disorders in hashimoto disease and euthyroid goitre: not only depressive but also anxiety disorders are associated with thyroid autoimmunity. | to evaluate the association between mood and anxiety disorders in hashimoto disease and euthyroid goitre in a case control study. | 2005 | 16285879 |
| electrophilic activation of lactams with tf2o and pyridine: expedient synthesis of (+/-)-tetraponerine t4. | [reaction: see text] the electrophilic activation of lactams with triflic anhydride in the presence of pyridine was investigated by nmr. it was found that 2-pyrrolidone led to the clean formation of the corresponding pyridinium imidate in 89% isolated yield. the subsequent nucleophilic addition of organometallic reagents led to 2-substituted dihydropyridines. a synthesis of (+/-)-tetraponerine t4 with three simple building blocks was accomplished in 3 steps (38% yield). | 2005 | 16288516 |
| vancomycin stress response in a sensitive and a tolerant strain of streptococcus pneumoniae. | the vancomycin stress response was studied in streptococcus pneumoniae strains t4 (tigr4) and tupelo. vancomycin affected the expression of 175 genes, including genes encoding transport functions and enzymes involved in aminosugar metabolism. the two-component systems tcs03, tcs11, and ciarh also responded to antibiotic treatment. we hypothesize that the three regulons are an important part of the bacterium's response to vancomycin stress. | 2005 | 16291696 |
| thermodynamics of an incommensurate quantum crystal. | we present a theory of the thermodynamics of an incommensurate quantum solid. the ground state of the solid is assumed to be an incommensurate crystal, with quantum zero-point vacancies and interstitials and thus a non-integer number of atoms per unit cell. we show that at low temperature t, the variation of the net vacancy concentration should be as t4 and that the first correction to the specific heat due to this varies as t7; these are quite consistent with experiments on solid helium-4. we a ... | 2005 | 16293755 |
| effects of in utero and lactational exposure to bisphenol a on thyroid status in f1 rat offspring. | bisphenol a (bpa), a xenoestrogen, has been reported to mimic the actions of estrogen or to affect the endocrine glands in vivo and in vitro. in this study, we examined whether in utero and lactational exposure to bpa alters thyroid status in rat f1 offspring. dams were orally administered various doses of bpa (0, 4 or 40 mg/kg body weight per day) from gestation day (gd) 6 through postnatal day (pnd) 20. the bpa and control groups did not differ significantly with respect to plasma thyroxine (t ... | 2005 | 16294924 |
| pathogenic acanthamoeba strains from water sources in jamaica, west indies. | in 2004, samples of tap water and of river and sea water associated with human activities were collected in jamaica, west indies, and checked for free-living acanthamoeba. the morphologies of the cysts and trophozoites observed and the results of pcr-based amplifications with a genus-specific primer pair were used to identify the acanthamoeba isolates. the potential of each isolate as a human pathogen was then evaluated using thermotolerance and osmotolerance assays and two pcr-based assays for ... | 2005 | 16297288 |
| combined radiotherapy, 5-fluorouracil continuous infusion and weekly oxaliplatin in advanced rectal cancer: a phase i study. | the aim of this study was to determine the maximum-tolerated dose (mtd) of weekly oxaliplatin combined with 5-fluorouracil (5fu) continuous infusion administered concomitantly with fractionated radiotherapy in patients presenting advanced rectal cancer. forty-three patients with rectal cancer (stage t3/t4 (n = 24), metastatic (n = 17) and 2 with local recurrence), were included. the radiotherapy dose delivered was 45 gy over 5 weeks (1.8 gy/fraction/day, 5 days per week). the initial weekly oxal ... | 2005 | 16297614 |
| effect of substituting allogenic blood transfusion with autologous blood transfusion on outcomes after radical oesophagectomy for cancer. | the oncologic benefit of avoiding allogenic blood transfusion in oesophageal cancer resection has not been studied. | 2005 | 16299455 |
| l-thyroxine responsive cricopharyngeal achalasia associated with hypothyroidism in a dog. | an eight-year-old, male boxer dog was presented with a one-month history of hindlimb weakness followed by compulsive ineffective drinking, dysphagia, regurgitation and nasal reflux during drinking. a neurological examination revealed weakness and conscious proprioception deficits in both hindlimbs with normal spinal reflexes. the dog's swallowing function was examined by fluoroscopy. this showed normal prehension of the barium paste, bolus formation and contraction of the pharyngeal muscle, but ... | 2005 | 16300118 |
| template-independent ligation of single-stranded dna by t4 dna ligase. | t4 dna ligase is one of the workhorses of molecular biology and used in various biotechnological applications. here we report that this ligase, unlike escherichia coli dna ligase, taq dna ligase and ampligase, is able to join the ends of single-stranded dna in the absence of any duplex dna structure at the ligation site. such nontemplated ligation of dna oligomers catalyzed by t4 dna ligase occurs with a very low yield, as assessed by quantitative competitive pcr, between 10(-6) and 10(-4) at ol ... | 2005 | 16302964 |
| survivin expression and its relationship with apoptosis and prognosis in nasal and paranasal sinus carcinomas. | the inverse correlation found in this study between survivin expression and the level of spontaneous apoptosis in nasal and paranasal sinus carcinoma (npsc) suggests that survivin may play an important role in the tumorigenesis of npsc. survivin expression may provide a novel predictive indicator for disease-free survival after surgical resection and postoperative radiochemotherapy in npsc. | 2005 | 16303685 |
| comparison of antihypertensives after coronary artery surgery. | hypertension following coronary artery bypass grafting is a common problem that may result in postoperative myocardial infraction or bleeding, hemodynamic effects were compared in 45 hypertensive coronary bypass patients randomized to receive either diltiazem, nitroglycerin, or sodium nitroprusside. diltiazem was administered as an intravenous bolus of 0.3 mg.kg-1 within 5 min, followed by infusion of 0.1-0.8 mg.kg-1.h-1 in group 1. nitroglycerin was infused at a rate of 1-3 microg.kg.h-1 in gro ... | 2005 | 16304214 |
| treatment with rhenium-188-perrhenate and iodine-131 of nis-expressing mammary cancer in a mouse model remarkably inhibited tumor growth. | novel therapeutic modalities are needed for breast cancer patients in whom standard treatments are not effective. mammary gland sodium/iodide symporter has been identified as a molecular target in breast cancers in humans and in some transgenic mouse models. we report the results of a therapy study with (131)i(-) and (188)reo(4)(-) of breast cancer in polyoma middle t oncoprotein (pymt) transgenic mice endogenously expressing the na(+)/i(-) symporter (nis). | 2005 | 16243644 |
| clinical features of hepatocellular carcinoma with extrahepatic metastases. | there are few detailed clinical reports about extrahepatic metastases of hepatocellular carcinoma (hcc). the purpose of the present study was to elucidate the clinical features of extrahepatic metastases of hcc. | 2005 | 16246200 |
| surgical approaches to the cervico-thoracic junction. | the cervico-thoracic junction (ctj) extends between the 7th cervical and the 4th thoracic vertebrae and comprehends the inferior portion of the brachial plexus and the parenchymatous, vascular and nervous structures of the upper mediastinum. the posterior surgical approaches, as the laminectomy or the arthro-pediclectomy, fail to expose the anterior spinal elements. thus, further surgical approaches have been proposed: postero-lateral, antero-lateral (thoracotomies) and purely anterior. the aim ... | 2005 | 16247344 |
| antiviral activity of steric-block oligonucleotides targeting the hiv-1 trans-activation response and packaging signal stem-loop rnas. | mixmer oligonucleotides consisting of residues of both 2'-o-methylnucleosides (ome) and locked nucleic acids (lna) were designed targeting two stem-loops in the 5'-utr of hiv-1 rna, the transactivation response region (tar), which is the site of binding of the tat protein, and the sl3 loop, which is the primary packaging element that binds the gag polyprotein. these oligonucleotides were found to inhibit syncitia formation dose- and sequence-dependently when delivered to hela t4 ltr beta-gal cel ... | 2005 | 16247957 |
| synthesis and characterization of dna duplexes containing an n3t-ethyl-n3t interstrand crosslink in opposite orientations. | dna duplexes containing an ethyl interstrand crosslink that bridges the n3 atoms of thymidines on the opposite strands have been synthesized using an approach that combines conventional solid phase oligonucleotide synthesis and the selective removal of protecting groups of a crosslinked thymidine dimer. this approach allows for the assembly of a crosslinked duplex directly on the solid support. duplexes that contain a n3t-ethyl-n3t interstrand crosslink in a staggered orientation at either a -ta ... | 2005 | 16248073 |
| [the role of neoadjuvant therapy in the treatment of locally advanced, stage iii non-small-cell lung cancer]. | to review the progress achieved in the neoadjuvant treatment of patients with locally advanced nsclc by evaluating the articles published during the last 10 years. | 2005 | 16249813 |
| optimizing splinted ligation of highly structured small rnas. | the synthesis of highly structured small rnas containing nonstandard nucleotides is of high interest for structural and functional investigations. a general approach is the joining, by t4 dna ligase-mediated splinted ligation, of two or more rna fragments, each of which may contain its own set of modified nucleotides. the rna fragments hybridize with a complementary dna splint to form a ternary ligation-competent-complex (lcc), which is then turned over by the dna ligase. we studied the formatio ... | 2005 | 16251384 |
| neoadjuvant chemotherapy in transitional-cell carcinoma of the bladder. | neoadjuvant chemotherapy in transitional-cell carcinoma of the bladder (tcc) improves survival. this is one of the most important developments in the management of muscle-invasive bladder cancer in recent times. there is an improved absolute 5-year survival of at least 5% for t2-t4 disease. to achieve this benefit, a cisplatin-containing combination is required. there is no difference in survival whether radical radiotherapy or radical cystectomy is given as subsequent definitive treatment. | 2005 | 16238137 |
| symmetry of the nose after presurgical nasoalveolar molding in infants with unilateral cleft lip and palate: a preliminary study. | to assess nostril symmetry and alveolar cleft width in infants with unilateral cleft lip and palate following presurgical nasoalveolar molding (nam). | 2005 | 16241178 |
| specific heat of a fermionic atomic cloud in the unitary regime. | in the unitary regime, when the scattering amplitude greatly exceeds in magnitude the average interparticle separation, and below the critical temperature thermal properties of an atomic fermionic cloud are governed by the collective modes, specifically the bogoliubov-anderson sound modes. the specific heat of an atomic cloud in an elongated trap, in particular, has a rather complex temperature dependence, which changes from an exponential behavior at very low temperatures (t << h omega(parallel ... | 2005 | 16241633 |
| hypobaric spinal anesthesia with 0.2% tetracaine for total joint hip arthroplasy. | hypobaric local anesthetics for total hip replacement (thr) have potential advantages related to body position and differential block. however, the dose requirements of hypobaric local anesthetics for thr have not been clearly established. therefore, we undertook a dose-response study of hypobaric tetracaine for thr. | 2005 | 16251562 |
| thyroid autoimmunity, depression and anxiety; are there any connections? an epidemiological study of a large population. | the aim of the study was to examine the relationship between antithyroid antibodies, depression, and anxiety in a large population. | 2005 | 16253615 |
| elevation of serum adiponectin levels in basedow disease. | the present study was undertaken to determine whether thyroid hormone affects serum adiponectin levels in the patients with basedow disease. sixty-four patients with basedow disease were examined; 32 patients had hyperthyroid state and 32 patients had euthyroid state who had been treated with antithyroid drugs. in addition, 30 age- and sex-matched subjects served as a control. serum adiponectin, free t4, free t3, thyroid-stimulating hormone, and thyroid-stimulating hormone receptor antibody (tra ... | 2005 | 16253634 |
| the t4 syndrome. | 2005 | 16253863 | |
| basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the zenith study. | this paper describes baseline data on basal metabolic rate (bmr), thyroid hormone levels and body composition of middle-aged and older people participating in the zenith project and the correlation of thyroid hormone levels with zinc status. | 2005 | 16254583 |
| pathological distribution of positive lymph nodes in patients with clinically and radiologically n0 oropharyngeal carcinoma: implications for imrt treatment planning. | we identified involved lymph node groups in patients with oropharyngeal carcinoma and radiologically n0 disease, aiming to define the clinical target volume, and to assess the negative predictive value of ct neck and correlate it to the tumor site, stage, and grade. | 2005 | 16259872 |
| [changes in hemodynamics and nitric oxide/endothelin-1 during liver transplantation in patients with cirrhosis]. | to study the systemic and pulmonary hemodynamic changes of patients with cirrhosis during liver transplantation and evaluate the role of nitric oxide (no) and endothelin-1(et-1). | 2005 | 16259914 |
| [changes in oxygen metabolism in hepatitis b gravis in peri-operative stages of orthotopic liver transplantation]. | to investigate the changes in oxygen metabolism in peri-operative stages in hepatitis b gravis and non-hepatitis b gravis undergoing orthotopic liver transplantation (olt). | 2005 | 16259915 |
| environmental signals: synthetic humic substances act as xeno-estrogen and affect the thyroid system of xenopus laevis. | according to outdated paradigms humic substances (hs) are considered to be refractory or inert that do not directly interact with aquatic organisms. however, they are taken up and induce biotransformation activities and may act as hormone-like substances. in the present study, we tested whether hs can interfere with endocrine regulation in the amphibian xenopus laevis. in order to exclude contamination with phyto-hormones, which may occur in environmental isolates, the artificial hs1500 was appl ... | 2005 | 16263388 |
| thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. | endocrine disruption from environmental contaminants has been linked to a broad spectrum of adverse outcomes. one concern about endocrine-disrupting xenobiotics is the potential for additive or synergistic (i.e., greater-than-additive) effects of mixtures. a short-term dosing model to examine the effects of environmental mixtures on thyroid homeostasis has been developed. prototypic thyroid-disrupting chemicals (tdcs) such as dioxins, polychlorinated biphenyls (pcbs), and polybrominated diphenyl ... | 2005 | 16263510 |
| in utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns. | the aim of this study is to examine the association between transplacental exposure to dioxins/polychlorinated biphenyls (pcbs) and thyroid and growth hormones in newborns. we recruited 118 pregnant women, between 25 and 34 years of age, at the obstetric clinic. personal data collected included reproductive and medical histories and physical factors. clinicians gathered placental and umbilical cord serum upon delivery and carefully scored the 118 newborns, making both structural and functional a ... | 2005 | 16263525 |
| osteopontin gene expression in the aorta and the heart of propylthiouracil-induced hypothyroid mice. | it is known that there is abnormal osteopontin (opn) expression at the sites of atherosclerotic lesions. in the apolipoprotein e gene knockout (apoe-ko) mouse, a model of the atherosclerotic process, altered cholesterol metabolism with associated increase in opn expression is evident at 12-22 weeks in the aorta and at 22 weeks in the heart. in this study, we analyzed another animal model of hypothyroid mice created by ingestion of propylthiouracil (ptu). after 2 weeks of ptu ingestion, the anima ... | 2005 | 16265595 |
| [future organisation of colorectal cancer surgery in denmark]. | we recommend that in the future, surgery for colorectal cancer (crc) in denmark should be done in 10 to 15 colorectal units with an uptake zone of 350,000-500,000 citizens each. these units should perform both acute and elective crc surgery and acute surgical treatment of other intestinal diseases. in each unit, a senior colorectal surgeon should be available on a 24-hour shift, and there should be sufficient diagnostic and theatre capacity to ensure optimal treatment levels. a stoma clinic shou ... | 2005 | 16266578 |
| the role of door orientation on occupant injury in a nearside impact: a ciren, madymo modeling and experimental study. | this study addressed the effects of vehicle height mismatch in side impact crashes. a light truck or suv tends to strike the door of a passenger car higher causing the upper border to lead into the occupant space. conversely, an impact centered lower on the door, from a passenger car, causes the lower border to lead. we proposed the hypothesis that the type of injury sustained by the occupant could be related to door orientation during its intrusion into the passenger compartment. | 2005 | 16266946 |
| [should we detect osteoporosis, and how?]. | osteoporotic vertebral and hip fractures, which are very frequent among elderly, are associated to an excess of mortality, as well as to an important morbidity. in switzerland, annual costs of in-patients' treatments of osteoporosis are beyond chf 700 millions. as several effective treatments against osteoporosis are available, a systematic screening is justified. the methodical search for risk factors of fracture and the recognized medical indications for bone densitometry are of prime necessit ... | 2005 | 16268446 |
| cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation. | formation of a water-expelling nonpolar core is the paradigm of protein folding and stability. although experiment largely confirms this picture, water buried in "hydrophobic" cavities is required for the function of some proteins. hydration of the protein core has also been suggested as the mechanism of pressure-induced unfolding. we therefore are led to ask whether even the most nonpolar protein core is truly hydrophobic (i.e., water-repelling). to answer this question we probed the hydration ... | 2005 | 16269539 |
| umbilical cord blood tsh levels in term neonates: a screening tool for congenital hypothyroidism. | this study was conducted to find normative values for thyroid stimulating hormone (tsh) in 1200 cord blood samples of term babies whose mothers were not on any thyroid medications. tsh was estimated within 24 hrs by enzyme immunoassay. a full thyroid profile, viz, t3, t4, tsh, ft3 and ft4 was done at 7-10 days of age in all babies with cord tsh >20 miu/l. the mean, median and standard deviation for the tsh values for the cohort were 6.13 miu/l, 5.8 miu/l and 4.523 respectively. 22 babies with ts ... | 2005 | 16269841 |
| rate of recalls in congenital hypothyroidism based upon a regional survey in isfahan, iran, using serum t4 and tsh analyses: comparison of two different recall methods. | to evaluate and compare the recall rate in congenital hypothyroidism screening project in isfahan, first using an approach involving measures of both tsh and t4 and then using tsh alone. | 2005 | 16269871 |
| preoperative chemotherapy in children with high-risk medulloblastomas: a feasibility study. | the authors set out to evaluate the feasibility and effectiveness of preoperative chemotherapy in treating high-risk medulloblastomas. | 2005 | 16270682 |
| [expression of adrenomedullin in the tissue with laryngeal carcinoma]. | to observe the expression of adrenomedullin (am) in the patients with laryngeal carcinoma. | 2005 | 16270874 |
| [treatment and survival analysis of pyriform sinus cancer]. | to evaluate the efficacy of surgery for the patients with pyriform sinus carcinoma and analyze the prognostic factors related to the cancer. | 2005 | 16270875 |
| functional role of the n-terminal domain of bacteriophage t4 gene product 11. | bacteriophage t4 late gene product 11 (gp11), the three-dimensional structure of which has been solved by us to 2.0 a resolution, is a part of the virus' baseplate. the gp11 polypeptide chain consists of 219 amino acid residues and the functionally active protein is a three-domain homotrimer. in this work, we have studied the role of gp11 n-terminal domain in the formation of a functionally active trimer. deletion variants of gp11 and monoclonal antibodies recognizing the native conformation of ... | 2005 | 16271026 |
| distance between the skin and the thoracic paravertebral space. | a fundamental requirement for the safe and effective performance of paravertebral blockade is reliable estimates of the depth from skin to paravertebral space at different thoracic levels. this distance was assessed using a nerve stimulator guided paravertebral blockade technique in 527 separate blocks in 186 patients scheduled for various surgical procedures on the trunk. the median skin-paravertebral depth was 55.0 mm. the skin-paravertebral distance at upper (t1-3) and lower (t9-12) thoracic ... | 2005 | 15960719 |
| reduction in vertebral fracture risk in teriparatide-treated postmenopausal women as assessed by spinal deformity index. | teriparatide is the first bone-building drug available for the treatment of osteoporosis. we investigated the efficacy of this compound as assessed by spinal deformity index (sdi) using data from the fracture prevention trial (fpt). the fpt was a randomized, double blind trial of placebo versus teriparatide 20 microg (tptd20) versus teriparatide 40 microg (tptd40) administered by daily self-injection. patients included in the current analyses were those patients from the placebo (n = 398) and tp ... | 2005 | 15961357 |
| clinical impact of criteria for complete response (cr) of primary site to treatment of esophageal cancer. | with the development of chemoradiotherapy for esophageal cancer, the complete response (cr) rate would become an important surrogate end-point. however, the response evaluation criteria in solid tumors (recist) do not provide criteria for a response at the primary site of esophageal cancer. the objective of this study was to assess the validity of the endoscopic cr criteria for the primary site of esophageal cancer treated with chemoradiotherapy. | 2005 | 15961436 |
| real-time investigation of nucleic acids phosphorylation process using molecular beacons. | phosphorylation of nucleic acids is an indispensable process to repair strand interruption of nucleic acids. we have studied the process of phosphorylation using molecular beacon (mb) dna probes in real-time and with high selectivity. the mb employed in this method is devised to sense the product of a 'phosphorylation-ligation' coupled enzyme reaction. compared with the current assays, this novel method is convenient, fast, selective, highly sensitive and capable of real-time monitoring in a hom ... | 2005 | 15961728 |
| [transitional cell carcinoma of the upper urinary tract new concepts in management]. | transitional cell carcinomas of the upper urinary tract (uut-tccs) are rare: they account for approximately 5% of all urothelial carcinomas. 30% of patients with uut-tcc have a history of bladder tcc, but fewer than 2% of patients with bladder tcc have uut-tcc. tumor microsatellite instability (msi) is an indicator of the clonal expansion of neoplasms; it was first identified in tumors from patients with hereditary non-polyposis colorectal carcinoma (hnpcc). uut-tcc occurs in 5% of patients with ... | 2005 | 15962502 |
| evaluation of analytical methods and workflow performance of the architect ci8200 integrated serum/plasma analyzer system. | the architect ci8200 is an integrated serum analyzer for photometric, electrochemical and immunological assays. several assays of each category and the workflow performance of the system were compared with established laboratory procedures in two laboratories. | 2005 | 15963793 |
| acanthamoeba isolates belonging to t1, t2, t3, t4 but not t7 encyst in response to increased osmolarity and cysts do not bind to human corneal epithelial cells. | acanthamoeba is an opportunistic protozoan that is widely distributed in the environment and can cause human infections. the life cycle of acanthamoeba consists of an infective trophozoite form. however under harsh environmental conditions trophozoites differentiate into a double-walled, metabolically inactive and resistant cyst form. research in acanthamoeba has mostly focussed on the infective trophozoite form and its pathogenic mechanisms. in this study, we used acanthamoeba isolates belongin ... | 2005 | 15963936 |
| a new index of flat breaststroke propulsion: a comparison of elite men and women. | this study examined arm and leg coordination and propulsion during the flat breaststroke in nine elite male and eight elite female swimmers over three race paces (200 m, 100 m and 50 m). coordination was expressed using four temporal gaps (t1, t2, t3, t4), which described the continuity between the propulsive phases of the limbs, as recorded on a video device (50 hz). glide duration was denoted t1, the time between the beginning of arm and leg recovery was denoted t2, the time between the end of ... | 2005 | 15966349 |
| thyroid function differently affects serum cystatin c and creatinine concentrations. | cystatin c (cys c) is a cysteine protease inhibitor produced at a constant rate by nucleated cells, filtered through the glomerular membrane and reabsorbed by kidney tubular cells. aim of this cross-sectional and longitudinal study was to assess serum cys c and creatinine (crea) concentrations in thyroid dysfunction. one hundred and eighty-one patients, 26 with untreated non-toxic nodular goiter, 58 with hyperthyroidism, 31 on l-t4 suppressive therapy for non-toxic nodular goiter, 35 with short- ... | 2005 | 15966508 |
| resistance to thyroid hormone associated with autoimmune thyroid disease in a turkish family. | the syndrome of resistance to thyroid hormone (rth) is characterized by impaired tissue responses to thyroid hormone. hashimoto's thyroiditis is the most common thyroid autoimmune disease. we present a turkish family with both rth and hashimoto's thyroiditis. rth was detected through the presence of point mutation in thyroid hormone receptor (tr), and hashimoto's thyroiditis was diagnosed due to the presence of thyroid autoantibodies. the proposita, her affected mother as well as her unaffected ... | 2005 | 15966514 |
| non-genomic effect of steroids on oxytocin-stimulated intracellular mobilization of calcium and on prostaglandin f2alpha and e2 secretion from bovine endometrial cells. | progesterone (p4) was found to interfere directly with the interaction of oxytocin (ot) with its own receptor in bovine endometrium. the aim of these studies was to investigate whether other steroids have a similar effect. endometrial slices and epithelial endometrial cells from days 14 to 18 of the estrous cycle were used. progesterone (p4), pregnenolone (p5), 17beta-hydroxyprogesterone (17-ohp4), the p4 receptor antagonist (ap4), and testosterone (t4) did not affect (p > 0.01) basal secretion ... | 2005 | 15967166 |