Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| marine t4-type bacteriophages, a ubiquitous component of the dark matter of the biosphere. | tailed bacteriophages are the most abundant biological entities in marine environments. however, most of these marine phages are uncharacterized because few of their hosts have been cultivated. to learn more about such phages, we designed a set of degenerate pcr primers for phage t4 g23, which encodes the major capsid protein in all of the t4-type phages, an important family of the tailed phage. these primers were used to amplify g23-related sequences from diverse marine environments (fjords and ... | 2005 | 16116082 |
| lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy. | we hypothesized that bladder cancer patients with associated lymphovascular invasion (lvi) are at increased risk of occult metastases. | 2005 | 16116151 |
| the proangiogenic action of thyroid hormone analogue gc-1 is initiated at an integrin. | our early reported investigations have demonstrated potent proangiogenic effects of l-thyroxine (t4) and 3,5,3'-triiodo-l-thyronine (t3) in the chick chorioallantoic membrane (cam) model. tetraiodothyroacetic acid (tetrac) blocks t4 binding to plasma membranes and its pro-angiogenic effect. t4/t3 stimulates expression of fibroblast growth factor 2 (fgf2) in endothelial cells. thyroid hormone (t4/t3) is principally responsible for transcriptional activation mediated by nuclear thyroid hormone rec ... | 2005 | 16116342 |
| the tail structure of bacteriophage t4 and its mechanism of contraction. | bacteriophage t4 and related viruses have a contractile tail that serves as an efficient mechanical device for infecting bacteria. a three-dimensional cryo-em reconstruction of the mature t4 tail assembly at 15-a resolution shows the hexagonal dome-shaped baseplate, the extended contractile sheath, the long tail fibers attached to the baseplate and the collar formed by six whiskers that interact with the long tail fibers. comparison with the structure of the contracted tail shows that tail contr ... | 2005 | 16116440 |
| high pressure liquid chormatography determination of the concentration and integrity of l-thyroxine in free t4 stock solution. | characterization studies were designed to evaluate the concentration and integrity of the l-thyroxine (t4) molecule (3,5,3',5'-tetraiodothyronine) in the free t4 stock solution (ft4ss) (code 99544). the determination of the concentration of t4 in ft4ss is critical to ensure that the free t4 calibrators and controls are manufactured with the least number of adjustments possible. the most significant conclusions drawn from these characterization studies are the following: (1) an accurate and sensi ... | 2005 | 16116934 |
| long-term course and predictive factors of elevated serum thyroglobulin and negative diagnostic radioiodine whole body scan in differentiated thyroid cancer. | following the initial management, some patients with differentiated thyroid cancer (dtc) develop a state of high thyroglobulin (tg) and negative diagnostic radioactive iodine (rai) whole body scan (dxwbs). the predisposing factors and outcome of this condition are unclear. in this study, our objectives were to determine the predictive factors for the development of high tg and negative dxwbs (tg+/scan-) and to study the long-term course of the disease in patients with this condition. | 2005 | 16117196 |
| [new clinical staging system for carcinoma of nasal cavity]. | to establish a new staging system based on analysis of several presently used clinical staging systems for carcinoma of nasal cavity. | 2005 | 16117899 |
| accelerated radiotherapy for advanced laryngeal cancer. | the purpose of this study was to evaluate a single institution's outcome for patients with advanced laryngeal cancer treated with accelerated radiotherapy (rt). fifty-eight patients with advanced laryngeal cancer (t3/t4n0/n + m0) were treated with curative intent with accelerated rt during the period 1990-1998. patients received radiotherapy alone or with induction chemotherapy. the 5-year local control (lc) and loco-regional control (lrc) probabilities were both 49% for t3 and 75% for t4 tumors ... | 2005 | 16118082 |
| endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. | up to 40% of thoracotomies performed for non-small cell lung cancer are unnecessary, predominantly due to inaccurate preoperative detection of lymph node metastases and mediastinal tumor invasion (t4). mediastinoscopy and the novel, minimally invasive technique of transesophageal ultrasound-guided fine-needle aspiration (eus-fna) target different mediastinal lymph node stations. in addition, eus can identify tumor invasion in neighboring organs if tumors are located adjacent to the esophagus. | 2005 | 16118383 |
| quantitative eeg analysis of rem sleep in children with down syndrome. | the aim was to compare quantitative eeg analysis of rem sleep in children with down syndrome (ds) and normal age-matched controls. | 2005 | 16119618 |
| [molecular analysis of streptococcal pyrogenic exotoxin genes among group a streptococcus isolates from japanese patients with pharyngitis and skin infections]. | group a streptococci (gas) from patients with pharyngitis and skin infections were examined for t serotypes, emm types, and streptococcal pyrogenic exotoxin gene types. the results were summarized as follows: 1) t and emm types were determined in 130 gas isolates obtained between 2000 and 2004. among 85 throat isolates, predominant t/emm types were t12/emm12 (25%), t4/emm4 (19%), and t1/emm1 (14%). among 45 skin isolates, predominant t/emm types were t28/emm28 (13%), tb 3264/emm89 (13%), tnontyp ... | 2005 | 16119802 |
| effects of grapefruit juice on the absorption of levothyroxine. | our aim was to study the effect of grapefruit juice on the pharmacokinetics of levothyroxine. | 2005 | 16120075 |
| t-cell receptor gamma gene rearrangement by multiplex polymerase chain reaction/heteroduplex analysis in patients with cutaneous t-cell lymphoma (mycosis fungoides/sézary syndrome) and benign inflammatory disease: correlation with clinical, histological and immunophenotypical findings. | a dominant t-cell clone can be detected by polymerase chain reaction (pcr) in 40-90% of cutaneous samples from patients with cutaneous t-cell lymphoma (ctcl). | 2005 | 16120144 |
| clinicopathological features, surgical management, and disease outcome of perforated gastric cancer. | perforated gastric cancer is rare and generally not diagnosed preoperatively or intraoperatively, if a frozen section is unavailable. therefore, the elucidation of its clinicopathological features and disease outcomes will help surgeons manage perforated gastric cancer. | 2005 | 16121341 |
| the prognostic significance of p53, p27 kip1, p21 waf1, her-2/neu, and ki67 proteins expression in gastric cancer: a clinicopathological and immunohistochemical study of 121 arab patients. | the variability of prognosis within a pathological stage of gastric cancer (gc) at presentation, underscores the need for specific biological markers to identify subgroups of patients with aggressive course for intensive treatment. to our knowledge, this is the first study from an arab population reporting on the relationship of p53, p27 kip1, p21 waf1, her-2/neu, and ki67 expression, and clinicopathological features and their prognostic significance. | 2005 | 16121348 |
| [prevalence of latent and manifest hyperthyroidism in an iodine-deficient area: non-selected patient population admitted for ct studies with iodine-containing contrast agents]. | to evaluate the prevalence of latent and manifest hyperthyroidism in a non-selected group of patients admitted for contrast enhanced ct studies blood samples were tested for the levels of thyroid-stimulating hormone (tsh). | 2005 | 16123871 |
| [ultrasound of hypopharyngeal and oesophageal cancer: possibilities and limitations to staging and planning of therapy]. | sonographic examination of the hypopharynx and the extrathoracic oesophagus can be difficult. therefore, most surgeons prefer to utilise ct or mri scanning. surgery is planned on the basis of endoscopic findings combined with radiologic information. the aim of the present prospective study was to demonstrate that the combination of ultrasonography and endoscopy provides a sufficient basis for the planning of surgical interventions in patients suffering from hypopharyngeal cancer or cancer of the ... | 2005 | 16123926 |
| structure of the central hub of bacteriophage mu baseplate determined by x-ray crystallography of gp44. | bacteriophage mu is a double-stranded dna phage that consists of an icosahedral head, a contractile tail with baseplate and six tail fibers, similar to the well-studied t-even phages. the baseplate of bacteriophage mu, which recognizes and attaches to a host cell during infection, consists of at least eight different proteins. the baseplate protein, gp44, is essential for bacteriophage mu assembly and the generation of viable phages. to investigate the role of gp44 in baseplate assembly and infe ... | 2005 | 16125724 |
| usefulness of the 2nd generation assay for anti-tsh receptor antibodies to differentiate relapse of graves' thyrotoxicosis from development of painless thyroiditis after antithyroid drug treatment for graves' disease. | after antithyroid drug (atd) treatment for graves' disease, either a relapse of graves' thyrotoxicosis or painless thyroiditis can develop. it is important to differentiate these two types of thyrotoxicosis because of the difference in required therapy. however, differentiation of thyrotoxicosis is usually difficult without radioactive iodine uptake (raiu) which is not available in general practice. we investigated the clinical usefulness of the 2nd generation assay for anti-tsh receptor antibod ... | 2005 | 16127219 |
| type 2 iodothyronine deiodinase is the major source of plasma t3 in euthyroid humans. | the relative roles of the types 1 and 2 iodothyronine deiodinases (d1 and d2) in extrathyroidal 3,5,3'-triiodothyronine (t3) production in humans are unknown. we calculated the rate of thyroxine (t4) to t3 conversion by intact cells transiently expressing d1 or d2 at low (2 pm), normal (20 pm), and high (200 pm) free t4 concentrations. deiodinase activities were then assayed in cell sonicates. the ratio of t3 production in cell sonicates (catalytic efficiency) was multiplied by the tissue activi ... | 2005 | 16127464 |
| [the evolution of epidemiology and clinical characteristics of laryngeal and hypopharyngeal carcinoma in poland from 1991 to 2001]. | on the base of retrospective analysis of 12,888 cases of carcinoma of larynx and hypopharynx, diagnosed in 19 ent departments in poland from 1991 to 2001, the assessment of basic epidemiological data, including the localization of tumor and stage of local and clinical advancement of the disease at the time of diagnosis has been conducted. in analyzed period of 11 years the trends to change of the mentioned above parameters has been examined. the significant increase of female patients in this pe ... | 2005 | 16095084 |
| [treatment results in external and middle ear malignant neoplasms of patients treated at the laryngology department of medical university of silesia between 1991-2001]. | the authors present 18 patients with malignant neoplasms of the ear and temporal bone who were treated in the clinic of laryngology medical university of silesia in katowice in the years 1991-2001. the most frequent was squamous cell carcinoma (11 patients--61%). the neoplasm was located on the auricle in 7 patients (39%), in the external auditory canal in 4 (22%) patients, in the middle ear in 5 patients (28%) and in 2 cases (11%) it was difficult to establish primary site. ten patients (55.5%) ... | 2005 | 16095085 |
| effect of levothyroxine administration on hemostatic analytes in doberman pinschers with von willebrand disease. | levothyroxine administration has been suggested to be an effective treatment for canine von willebrand disease (vwd), but evidence supporting this treatment is lacking. effects of levothyroxine administration were evaluated in 8 euthyroid doberman pinschers with plasma von willebrand factor (vwf) concentrations < 15%, characteristic of type 1 vwd. levothyroxine (0.04 mg/kg po q12h) and placebo were administered for 30 days in a 2-period, 2-treatment, double-blinded, crossover design with a 30-da ... | 2005 | 16095169 |
| the effect of a competitive collegiate football season on power performance and muscle oxygen recovery kinetics. | ten intercollegiate football players were tested within 3 days prior to (t1) and the day following the end (t2) of football preseason training camp and during weeks 7 (t3) and 11 (t4) of the competitive season. during each testing session, subjects performed a 30-second wingate anaerobic power test. near-infrared continuous wave spectroscopy was used to measure muscle deoxygenation during exercise. no changes in any power performance measures were seen during the competitive football season. a s ... | 2005 | 16095398 |
| bacterial lipopolysaccharide (lps)-induced type 2 iodothyronine deiodinase (d2) activation in the mediobasal hypothalamus (mbh) is independent of the lps-induced fall in serum thyroid hormone levels. | by administration of bacterial lipopolysaccharide (lps) to intact and t4-replaced thyroidectomized rats, we demonstrate that in contrast to the cortex and anterior pituitary, there is a persistent increase in type 2 iodothyronine deiodinase (d2) activity in the mediobasal hypothalamus (mbh). we propose that endotoxin-induced d2 activation in the mbh is independent of circulating levels of thyroid hormone and that this mechanism may contribute to central hypothyroidism associated with infection. | 2005 | 16095572 |
| effect of androgen deprivation therapy in the thyroid function test of patients with prostate cancer. | we have assessed the effect of androgen deprivation therapy (adt) in the thyroid function test in prostate cancer patients. serum levels of tri-iodothyronine (t3), thyroxine (t4), free thyroxine (ft4) and thyroid-stimulating hormone (tsh) were determined in a cross-sectional study that included 279 patients diagnosed with prostate cancer. a subset of 96 patients free of prostate-specific antigen relapse after radical prostatectomy became a control group and 183 patients under continuous adt form ... | 2005 | 16096434 |
| stress induced changes in lymphocyte subpopulations and associated cytokines during whole body hyperthermia of 41.8-42.2 degrees c. | extreme acute physical stress leads to transient impairment of t-lymphocytes, which are essential for tumor defence and prevention of infectious diseases. radiant whole body hyperthermia (wbh) at 41.8-42.2 degrees c may enhance the efficacy of systemic chemotherapy in patients with advanced malignancies, but is associated with marked physical stress. aim of this study was to demonstrate stress induced short-time effects on lymphocyte subpopulations and associated cytokines during wbh. total leuk ... | 2005 | 16096838 |
| three basic patterns of changes in serum thyroid hormone levels in graves' disease during the one-year period after radioiodine therapy. | the purpose of this study was to clarify the characteristic patterns of the thyroid hormonal changes in graves' disease during the one-year period after 131i therapy considering that few serial hormonal data during this period are available in the literature. | 2005 | 16097639 |
| selective inhibitors of terminal deoxyribonucleotidyltransferase (tdt): baicalin and genistin. | studies of mammalian terminal deoxyribonucleotidyltransferase (tdt) are facilitated by use of inhibitors that selectively knock down the activity of the enzyme. we have screened for selective inhibitors of tdt and identified a natural compound with this property in the japanese vegetable, arctium lappa. the compound has little effect on the activities of mammalian dna polymerases, such as alpha, beta, delta or lambda polymerase, and prokaryotic dna polymerases, such as taq dna polymerase, t4 dna ... | 2005 | 16099107 |
| stable trimerization of recombinant rabies virus glycoprotein ectodomain is required for interaction with the p75ntr receptor. | native rabies virus glycoprotein (rvgvir) is a trimeric, membrane-anchored protein that has been shown to interact with the p75ntr neurotrophin receptor. in order to determine if the rvg trimeric oligomerization state is required for its binding with p75ntr, different soluble recombinant molecules containing the entire rvg ectodomain (rvgect) were expressed alone or fused at its c terminus to the trimerization domain of the bacteriophage t4 fibritin, termed 'foldon'. the oligomerization status o ... | 2005 | 16099913 |
| relationship between interleukin-12-expressing cells and antigen-presenting cells in patients with colorectal cancer. | interleukin-12 (il-12) is a powerful cytokine that plays an important role in cell-mediated immunity. although il-12 is produced by antigen-presenting cells (apcs), the relationship between il-12 expression and apcs in colorectal cancer tissue remains unknown. | 2005 | 16101177 |
| survival analyses of breast cancer patients--the shaukat khanum memorial experience. | seven hundred subjects with breast cancer malignancies were followed up in time from december 1994 to december 2002 to determine survival distributions between sub-groups of breast cancer patients who had undergone surgical resection of the tumor followed by adjuvant treatment. tumor size, nodal status, and estrogen receptor (er) status at the time of presentation were ascertained. tumors were classified according to the tnm system of the american joint committee on cancer (ajcc), sixth edition, ... | 2005 | 16101321 |
| sentinel lymph node biopsy for cutaneous melanoma: the stanford experience, 1997-2004. | to review sentinel lymph node (sln) data from stanford university medical center from january 1, 1997, to january 1, 2004, including rates of sln positivity according to 2002 american joint committee on cancer (ajcc) tumor classification, relation to other clinical and pathologic prognostic factors, and rates and sites of melanoma recurrence. | 2005 | 16103331 |
| [effect of induction chemotherapy followed by surgery for bulky n2, t4 non-small cell lung cancer]. | it is controversial that the effect of induction chemotherapy for bulky n2, t4 non-small cell lung cancer. we examined a retrospective study to assess this issue. ten patients with bulky n2, t4 disease were given bronchial arterial infusion consisting of cisplatin (60 mg/m2) and docetaxel hydrate (60 mg/m2) intravenously, followed by standardized surgical resection (group a). thirty patients had pathological n2, t4 disease after surgery (group b). pathologically downstaging was seen in 6 patient ... | 2005 | 16104559 |
| dynamics of xenon binding inside the hydrophobic cavity of pseudo-wild-type bacteriophage t4 lysozyme explored through xenon-based nmr spectroscopy. | wild-type bacteriophage t4 lysozyme contains a hydrophobic cavity with binding properties that have been extensively studied by x-ray crystallography and nmr. in the present study, the monitoring of 1h chemical shift variations under xenon pressure enables the determination of the noble gas binding constant (k = 60.2 m(-1)). although the interaction site is highly localized, dipolar cross-relaxation effects between laser-polarized xenon and nearby protons (spinoe) are rather poor. this is explai ... | 2005 | 16104744 |
| serum thyroid hormones in preterm infants: associations with postnatal illnesses and drug usage. | transient hypothyroxinemia is common in infants less than 30 wk gestation and is associated with neurodevelopmental deficits. reductions in t4 and t3 levels with tsh unchanged are the key features of severe illness using surrogate indices of overall severity of illness, but these do not inform the impact of individual disease conditions or drug use. | 2005 | 16105964 |
| identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer. | extended lymphadenectomy for gastric carcinoma has been associated with high mortality and morbidity rates in several multicentre randomized trials. | 2005 | 16106493 |
| torsional stability of cross-link configurations: a biomechanical analysis. | cross-link systems have been used to augment segmental spinal instrumentation since the earliest introduction of these fixation systems. although transverse cross-links have little impact on sagittal motion of spinal constructs, cross-linkage does affect torsional rigidity. despite the wide variety of cross-link designs, almost all have been configured as transverse devices. the relative mechanical benefit of different cross-link configurations is not known. | 2005 | 16106560 |
| vector-capping: a simple method for preparing a high-quality full-length cdna library. | full-length cdnas play an essential role in identifying genes and determining their promoter regions. here we describe a simple method for constructing a full-length cdna library, which has the following advantages: (i) it consists of only three steps including direct ligation between a vector and a cdna strand using t4 rna ligase, (ii) it contains neither a pcr process generating mutations nor restriction enzyme treatment causing truncation of cdna, (iii) the intactness of cdna is assured due t ... | 2005 | 16106752 |
| [cloning and expression of fusarium moniliforme cgmcc 0536 d-lactonohydrolase gene in escherichia coli]. | the total cdna obtained through reverse transcription of f. oxysporum cgmcc 0536 mrna used as template, a fragment about 1.5kb was amplied with oligo(dt)15 primer and a gene specific primer designed on the base of the sequence of both nh2-terminus and the cdna sequence encoding d-lactonohydrolase of fusarium oxysporum reported on the ncbi, then the fragment was cloned to the pmd18-t vector and sequenced. the sequence encoding d-lactonohydrolase of f. moniliforme cgmcc 0536 shows a high homology ... | 2005 | 16108362 |
| the decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice: no correlation with formation of methylsulfonyl metabolites. | a relationship between formation of methylsulfonyl (meso2) metabolites of 2,2',4,5,5'-pentachlorobiphenyl (pentacb) and decrease in serum thyroxine (t4) level was examined in the rats and mice after a single i.p. injection of pentacb (342 micromol/kg body weight). in either rats or mice, levels of the 3- and 4-meso2 metabolites of pentacb in the liver and feces increased in a time-dependent fashion up to 8 days after pentacb-treatment. however, there was a marked difference between rats and mice ... | 2005 | 16109825 |
| novel biomarkers of perchlorate exposure in zebrafish. | perchlorate inhibits iodide uptake by thyroid follicles and lowers thyroid hormone production. although several effects of perchlorate on the thyroid system have been reported, the utility of these pathologies as markers of environmental perchlorate exposures has not been adequately assessed. the present study examined time-course and concentration-dependent effects of perchlorate on thyroid follicle hypertrophy, colloid depletion, and angiogenesis; alterations in whole-body thyroxine (t4) level ... | 2005 | 16110988 |
| oxidative stress and endocrine endpoints in white sucker (catostomus commersoni) from a river impacted by agricultural chemicals. | the effects of agricultural chemicals on cortisol secretion, antioxidants, and lipid peroxidation were investigated in hepatic and adrenal tissue of white sucker (catostomus commersoni) from a river (yamaska) that drains an agricultural region in québec (canada). plasma cholinesterase (che) activity, used as a biomarker of exposure to pesticides, was elevated in fish from the reference site compared to fish from the contaminated sites. plasma concentrations of cortisol and thyroid hormones (t3 a ... | 2005 | 16111011 |
| thyroid hormones and brain development. | the action of thyroid hormones (thyroxine, t4; triiodothyronine, t3) on brain development and function is gaining renewed interest. it has been known for many years that thyroid hormones are very important in mammalian brain maturation, influencing many aspects related to neural cell migration, differentiation, and signaling. in the last 10 years, genes regulated by thyroid hormones have been identified in the rodent brain, and understanding of the role of thyroid hormone nuclear receptors has b ... | 2005 | 16112266 |
| uv-specific dna repair recombinant fusion enzyme: a new stable pharmacologically active principle suitable for photoprotection. | uv radiation can produce mutations in skin cells and correlates strongly with the onset of actinic keratoses and basal and squamous cell carcinomas. xeroderma pigmentosum (xp) is a heritable disease characterized by an extreme sensitivity of skin to uv radiation. recently, studies in cultured cells as well as in xp patients have demonstrated that the recombinant t4 endonuclease v uv-specific endonuclease could enhance repair of uv-induced photoproducts. | 2005 | 16055003 |
| austrian moderate altitude study (amas 2000): erythropoietic activity and hb-o(2) affinity during a 3-week hiking holiday at moderate altitude in persons with metabolic syndrome. | moderate altitude hypoxia (1500 to 2500 m) is known to stimulate erythropoiesis and to improve oxygen transport to tissue by a reduction of hb-o(2) affinity. whether this adaptation also occurs in tourists with metabolic syndrome has not yet been investigated sufficiently. thus, we performed a prospective field study to measure erythropoietic parameters and oxygen transport properties in 24 male volunteers with metabolic syndrome during a 3- week holiday program at 1700 m consisting of four guid ... | 2005 | 16060851 |
| high prevalence of differentiated thyroid carcinoma in acromegaly. | acromegaly is a chronic disease caused by increased gh secretion and associated with a greater risk of developing both benign and malignant tumours. in the present study we evaluated the prevalence of thyroid disorders and thyroid malignancies in a series of acromegalic subjects. | 2005 | 16060909 |
| developmental changes of plasma inhibin, gonadotropins, steroid hormones, and thyroid hormones in male and female shao ducks. | plasma samples from developing male and female shao ducks were assayed for immunoreactive (ir-) inhibin, follicle-stimulating hormone (fsh), luteinizing hormone (lh), steroid hormones, and thyroid hormones. in the male, plasma ir-inhibin significantly increased between 75 and 155 days posthatch, and then decreased slightly at day 165. plasma fsh of male ducks decreased from day 35 to day 55, followed by progressive elevation until day 95. plasma fsh of male ducks fell significantly at days 135 a ... | 2005 | 16061074 |
| short-term oral toxicity of butyl ether, ethyl hexyl ether, methyl heptyl ether and 1,6-dimethoxyhexane in male rats and the role of 2-methoxyacetic acid. | a 4-week oral study was conducted in male rats to characterize and compare the toxicity of four aliphatic ethers (butyl ether, be; ethyl hexyl ether, ehxe; methyl heptyl ether, mhpe; and 1,6-dimethoxyhexane, dmh) which have been proposed as high-cetane diesel additives. male sprague-dawley rats (280+/-20 g) were divided into groups of seven animals each and were administered by gavage low (2mg/kg body weight), medium (20mg/kg) or high (200mg/kg) doses of be, ehxe, or mhpe, 5 days per week for 4 ... | 2005 | 16061321 |
| organ preservation and treatment toxicity with induction chemotherapy followed by radiation therapy or chemoradiation for advanced laryngeal cancer. | the authors reviewed records of patients with advanced laryngeal cancer treated with induction chemotherapy (ic) and hyperfractionated radiation therapy (rt) or chemoradiation (crt) to determine the rates of organ preservation and function. | 2005 | 16062079 |
| specific formation of beads-on-a-chain structures on giant dna using a designed polyamine derivative. | fluorescence microscopy was used to study the folding transition of giant dnas, t4 dna (ca. 166 kbp), and lambda dna (ca. 48 kbp), which proceeds through intermediates with intramolecular segregation induced by pteridine-polyamine conjugates, i.e., 2-amino-6,7-dimethyl-4-(4,9,13-triazatridecylamino)pteridine and -4-(3-(aminopropyl)amino)pteridine. according to the results of dna denaturation, uv and fluorescent spectroscopy, and transmission electron microscopic observations, it became clear tha ... | 2005 | 16076197 |
| the n-pentenoyl protecting group for aminoacyl-trnas. | the elaboration of misacylated transfer rnas by t4 rna ligase-mediated condensation of an aminoacylated pdcpa derivative and a trna (transcript) missing the two 3'-terminal nucleotides requires that the aminoacyl moiety of the dinucleotide be stabilized during the ligation reaction. this can be done conveniently by the use of a simple 4-pentenoyl group attached to n(alpha) of the amino acid. the pentenoyl amide can be deblocked readily with aqueous iodine, presumably via an iodolactone intermedi ... | 2005 | 16076450 |
| serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans. | polychlorinated biphenyls (pcbs) and dibenzofurans (pcdfs) are persistent environmental pollutants shown to adversely interact with several functions of the endocrine system. in 1978-1979, over 2000 taiwanese people ingested rice oil accidentally contaminated with pcbs and pcdfs. this is one of the major toxic exposure episodes that occurred globally and was later called yucheng (oil disease in chinese). the children born to exposed yucheng women were therefore exposed in utero to high doses of ... | 2005 | 16076757 |
| euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. | the objective of this study was to elucidate the influence of disease severity, deiodination, sulfation, thyroid hormone binding, and dopamine use on thyroid function in euthyroid sick syndrome. | 2005 | 16076941 |
| modulation of thyroid-specific gene expression in normal and nodular human thyroid tissues from adults: an in vivo effect of thyrotropin. | evidence from in vitro studies or animal models has shown that tsh affects thyrocytes by thyroid-specific expression modulation. | 2005 | 16076943 |
| hunger-satiety signals in patients with graves' thyrotoxicosis before, during, and after long-term pharmacological treatment. | patients with graves' thyrotoxicosis lose weight despite increased appetite and food intake, thus suggesting a disturbed balance between energy intake and expenditure. underlying mechanisms are not fully elucidated. the objective of this study was to investigate whether hormonal factors, known to affect hunger/satiety, change significantly over time as pharmacological treatment turns hyperthyroidism into euthyroidism. for that purpose 11 patients with graves' thyrotoxicosis were given thiamazole ... | 2005 | 16077172 |
| one hundred consecutive pneumonectomies after induction therapy for non-small cell lung cancer: an uncertain balance between risks and benefits. | we sought to assess postoperative outcome after pneumonectomy after neoadjuvant therapy in patients with non-small cell lung cancer. | 2005 | 16077407 |
| [expression of tgf-beta1 mrna in prostate carcinoma tissues and its significance]. | to investigate the expression of tgf-beta1 mrna in prostate carcinoma tissues and its significance. | 2005 | 16078668 |
| benchmark calculations for perchlorate from three human cohorts. | the presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. in a recently published report, the national academy of sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-day for months or longer. in this study, we calculated benchmark doses for perchlorate from thyroid-stimulating hormone (tsh) and free thyroxine (t4) serum indicators from two occup ... | 2005 | 16079070 |
| decrease of transthyretin synthesis at the blood-cerebrospinal fluid barrier of old sheep. | transthyretin (ttr), synthesized by the choroid plexus (cp) and secreted into cerebrospinal fluid (csf), is involved in thyroxine (t4) transport and chelation of beta-amyloid peptide, attenuating neurotoxicity. to characterize age-related changes in ttr synthesis, csf and cps were collected from young adult (1-2 years) and old (>8 years) sheep anesthetized with thiopentone sodium. ttr in old sheep csf was low compared to young (n = 4 each); however, cp messenger rna (mrna) for ttr did not change ... | 2005 | 16079207 |
| a comparison of the anti-luteolytic activities of recombinant ovine interferon-alpha and -tau in sheep. | interferon tau (ifnt) is secreted by the trophectoderm of ruminant conceptuses during the peri-implantation period and serves an anti-luteolytic function. the question as to whether ifnt is superior as an anti-luteolytic agent to closely related type i ifns, such as ifn alpha (ifna), which have a different function, remains unanswered. thus, the aim of this study was to determine whether equivalent antiviral (av) units of ovifna and ovifnt are equipotent in extending estrous cycle length. four d ... | 2005 | 16079305 |
| structural evidence of a passive base-flipping mechanism for agt, an unusual gt-b glycosyltransferase. | the escherichia coli t4 bacteriophage uses two glycosyltransferases to glucosylate and thus protect its dna: the retaining alpha-glucosyltransferase (agt) and the inverting beta-glucosyltransferase (bgt). they glucosylate 5-hydroxymethyl cytosine (5-hmc) bases of duplex dna using udp-glucose as the sugar donor to form an alpha-glucosidic linkage and a beta-glucosidic linkage, respectively. five structures of agt have been determined: a binary complex with the udp product and four ternary complex ... | 2005 | 16081100 |
| a three-dimensional cryo-electron microscopy structure of the bacteriophage phikz head. | the three-dimensional structure of the pseudomonas aeruginosa bacteriophage phikz head has been determined by cryo-electron microscopy and image reconstruction to 18a resolution. the head has icosahedral symmetry measuring 1455 a in diameter along 5-fold axes and a unique portal vertex to which is attached an approximately 1800 a-long contractile tail. the 65 kda major capsid protein, gp120, is organized into a surface lattice of hexamers, with t = 27 triangulation. the shape and size of the hex ... | 2005 | 16081102 |
| inactivation of particle-associated viral surrogates by ultraviolet light. | this study investigated whether colloid-sized particles can enmesh and protect viruses from 254-nm ultraviolet (uv) light and sought to determine the particle characteristics (e.g. size, chemical composition) that are most relevant in causing a protective effect. two viral surrogates (ms2 coliphage and bacteriophage t4), three types of particles (kaolin clay, humic acid powder, and activated sludge), two coagulants (alum and ferric chloride), two filtration conditions (none and 0.45 microm), and ... | 2005 | 16081130 |
| muts as a tool for mutation detection. | muts, a dna mismatch-binding protein, seems to be a promising tool for mutation detection. we present three muts based approaches to the detection of point mutations: dna retardation, protection of mismatched dna against exonuclease digestion, and chimeric muts proteins. dna retardation in polyacrylamide gels stained with sybr-gold allows mutation detection using 1-3 microg of thermus thermophilus his6-muts protein and 50-200 ng of a pcr product. the method enables the search for a broad range o ... | 2005 | 16082411 |
| perchlorate affects thyroid function in eastern mosquitofish (gambusia holbrooki) at environmentally relevant concentrations. | the purpose of this study was to determine the effects of perchlorate on thyroid function in mosquitofish. adult mosquitofish were exposed to 0, 0.1, 1, 10, 100, and 1000 mg/l sodium perchlorate for 2, 10, and 30 d. whole body thyroxin (t4) content and histological assessment of thyroid follicles (e.g., follicular epithelial height, hyperplasia, hypertrophy, and colloid depletion) were used to gauge alterations in thyroid function. follicular epithelial cell height, hyperplasia, and hypertrophy ... | 2005 | 16082946 |
| follow up of patients with postpartum thyroiditis: a population-based study. | in this survey we studied the prevalence of permanent hypothyroidism and prognostic factors for its occurrence 3-5 yr after postpartum thyroiditis (ppt); 54 of 120 women with ppt and 50 of 920 healthy women from among 1,040 women followed 4-5 yr earlier for ppt were recalled. demographic information, signs, and symptoms of thyroid disorders and results of physical exams were documented. serum t3, t4, rt3u, tsh, and anti-thyroperoxidase (anti-tpo ab) and anti-thyro-gluboline (anti-tg ab) antibodi ... | 2005 | 16230784 |
| influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure. | renal failure causes alterations in thyroid hormone metabolism known as nonthyroidal illness syndrome. in the present study we have examined the effect of a low protein diet (lpd) on circulating levels of hormones of the pituitary-thyroid axis, and tumor necrosis factor alpha (tnf-alpha) in patients with chronic renal failure. seventeen subjects with conservatively treated chronic renal failure (estimated creatinine clearance 39.5+/-11.1 ml/min) were studied before and after 8 wk of dietary inte ... | 2005 | 16230785 |
| design of ligand binding to an engineered protein cavity using virtual screening and thermal up-shift evaluation. | proteins could be used to carry and deliver small compounds. as a tool for designing ligand binding sites in protein cores, a three-step virtual screening method is presented that has been optimised using existing data on t4 lysozyme complexes and tested in a newly engineered cavity in flavodoxin. the method can pinpoint, in large databases, ligands of specific protein cavities. in the first step, physico-chemical filters are used to screen the library and discard a majority of compounds. in the ... | 2005 | 16231201 |
| ten-year follow-up of children born at <30 weeks' gestational age supplemented with thyroxine in the neonatal period in a randomized, controlled trial. | thyroid hormones are essential for brain development. we conducted a randomized, controlled trial with thyroxine (t4) supplementation in infants <30 weeks' gestation and with the last neurodevelopmental follow-up moment at the age of 5.5 years. t4 supplementation was associated with improved outcome of infants <28 weeks' gestation and worse outcome of infants of 29 weeks' gestation. we studied gestational age-dependent effects of t4 supplementation at the mean age of 10.5 years in children parti ... | 2005 | 16234230 |
| [surgical resection of t3 and t4 lung cancer]. | lung cancer invading neighboring anatomical structures such as the chest wall, pericardium, diaphragm, and left atrium are categorized as t3 or t4, which is regarded as locally advanced lung cancer. the purpose of this study was to evaluate results of surgical treatment of t3-4n0-2m0 non-small cell lung cancer according to involved organs. from 1981 to april 2005, 148 patients with lung cancer invading neighboring organs were surgically treated in our hospital. the 5-year survival was 41.4% in a ... | 2005 | 16235842 |
| [surgical resection for t4 lung cancer invading thoracic aorta]. | the prognosis of the lung cancer patients with aortic invasion is thought to be very poor in general. thoracic aorta resection and reconstruction was performed in 6 patients, aortic arch in 2, descending aorta in 4. an intraoperative and a postoperative major complication occurred in each 1 patient. five patients survived more than 1 year after operation, and 1 of them has been living without relapse for more than 5 years. pulmonary resection with the involved aorta can be done safely using card ... | 2005 | 16235844 |
| [the effect of multimodality induction therapy for locally advanced non-small cell lung cancer]. | in this study we analyzed induction therapy for locally advanced non-small cell lung cancer. eligible patients had mediastinoscopic proven n2 disease and t4 with mediastinal involvement. from january 1997 to may 2005, 56 patients entered the study. they received 2 cycle chemotherapy (platinums based 2 or 3 drugs), in 32 patients with concurrent radiotherapy followed by surgery. response rates were 57.1%. fifty-one patients underwent surgery. a radical resection was possible in 39 patients. compl ... | 2005 | 16235845 |
| [surgical treatment for locally advanced lung cancer; therapeutic response of induction chemotherapy and postoperative chemotherapy]. | the current chemotherapy has been able to give us many options to treat for lung cancer and recent studies have showed that perioperative chemotherapy may improve survival. in this study, we compared 2 groups with locally advanced lung cancers (stage iii, t3n0m0, inclusive of ipsilateral pm2, d1 and d2) ; group a, which had been treated by chemotherapy for downstaging prior to surgery (n = 23), and group b, which had been treated by surgery alone (n = 48). the postoperative 3- and 5-year overall ... | 2005 | 16235846 |
| [successful removal of t4 lung cancer with left atrial invasion after induction chemotherapy]. | a 53-year-old man presented with cough, sputa and chest pain. the chest x-ray revealed a large mass shadow in the right lower lobe. massive tumor extending into the left atrium was diagnosed by computed tomography (ct). the brushing cytology by broncoscopy was squamous cell carcinoma and its stage was iiib. chemothrapy using cisplatin, paclitaxel and gemcitabine hydrochloride was performed 8 courses during 6 months. the effect of the chemotherapy was complete response, enabling the surgical trea ... | 2005 | 16235848 |
| monoacetylcurcumin: a new inhibitor of eukaryotic dna polymerase lambda and a new ligand for inhibitor-affinity chromatography. | we previously reported that a phenolic compound, curcumin (diferuloylmethane), was a selective inhibitor of dna polymerase lambda (pol lambda) in vitro [y. mizushina, m. hirota, c. murakami, t. ishidoh, s. kamisuki, n. shimazaki, m. takemura, m. perpelescu, m. suzuki, h. yoshida, f. sugawara, o. koiwai, k. sakaguchi, some anti-chronic inflammatory compounds are dna polymerase lambda-specific inhibitors, biochem. pharmacol. 66 (2003) 1935-1944.]. we also found that monoacetylcurcumin ([1e,4z,6e]- ... | 2005 | 16236265 |
| the binding of xanthone derivatives to transthyretin. | a series of xanthone derivatives, isolated from calophyllum teysmannii var. inophylloide, have been evaluated for their binding affinity to transthyretin. transthyretin is a plasma protein involved in the transport of thyroxine (t4) and also implicated in amyloid diseases. using competition-binding studies with the protein natural ligand t4, we have identified one prenylated xanthone with a very strong affinity to transthyretin. molecular docking simulations show that the flexible tail of the pr ... | 2005 | 16236271 |
| vaccination against very virulent infectious bursal disease virus using recombinant t4 bacteriophage displaying viral protein vp2. | in order to develop a desirable inexpensive, effective and safe vaccine against the very virulent infectious bursal disease virus (vvibdv), we tried to take advantage of the emerging t4 bacteriophage surface protein display system. the major immunogen protein vp2 from the vvibdv strain hk46 was fused to the nonessential t4 phage surface capsid protein, a small outer capsid (soc) protein, resulting in the 49 kda soc-vp2 fusion protein, which was verified by sodium dodecylsulfate polyacrylamide ge ... | 2005 | 16215632 |
| an investigation of dna mismatch repair capacity under normal culture conditions and under conditions of supra-physiological challenge in human cd4+t cell clones from donors of different ages. | t cells undergo rapid clonal expansion upon antigenic stimulation to produce an effective immune response. any defect in the dna mismatch repair (mmr) system may have a detrimental effect on t cell proliferation. this study employed an in vitro model of human cd4+t cell ageing to investigate mmr capacity at various stages of t cell lifespan. a novel modification of the alkaline comet assay, which utilised t4 endonuclease vii to detect single base dna mismatches, was used to assess dna mismatch f ... | 2005 | 16216462 |
| effect of 10 yr of the iodine supplementation on the hearing threshold of iodine deficient schoolchildren. | auditory disturbances may be present in iodine deficient children. the aim of this study was to determine the effect of long-term iodine supplementation on auditory thresholds in iodine deficient children. | 2005 | 16218041 |
| a case-controlled study on the quality of life in a cohort of patients with history of differentiated thyroid carcinoma. | although quality of life (qol) has become an important aspect of cancer rehabilitation, psychometric studies on thyroid cancer patients are rare. we performed a case-controlled study on qol in patients with differentiated thyroid carcinoma (dtc). qol was evaluated in 61 patients with a history of dtc diagnosed from < 1 to 23 yr earlier. an undetectable thyroglobulin (tg) level after recombinant human tsh (rhtsh) testing was considered the best predictor of cure. qol was evaluated by means of a g ... | 2005 | 16218042 |
| lack of tsh inhibition by exogenous l-t4 in a patient with follicular thyroid carcinoma. | we report a case of a male patient thyroidectomized for follicular thyroid carcinoma and presenting extremely elevated serum thyrotropin levels under l-t4 suppressive therapy. administration of l-t3 in increasing amounts resulted in a significant decrease of serum tsh levels. the nature of the possible molecular defects underlying this unusual condition and pitfalls arising from the failure of l-t4 therapy to inhibit tsh secretion in a patient in post-surgical follow-up for follicular carcinoma ... | 2005 | 16218052 |
| regulation of the pituitary growth hormone-releasing hormone receptor in ageing male and female lou rats: new insights into healthy ageing. | ageing is characterised by a decrease of somatotroph functionality, involving growth hormone-releasing hormone receptor (ghrh-r). the present study was conducted in lou/c/jall (lou) rats, a strain described as a model of healthy ageing, which is characterised by a low adiposity and long life expectancy without developing severe pathologies. effects of age and diet (chow versus self-selection), on levels of anterior pituitary ghrh-r mrna transcripts, were assessed in male and female lou rats. the ... | 2005 | 16218997 |
| [staging 915 cases of nasopharyngeal carcinoma after simple radical radiotherapy--checkout of fuzhou staging system (1992)]. | along with the development of treatments, different tumor staging systems are coexisted and have been modified. this study was to validate the rationality of the fuzhou staging system (1992) of nasopharyngeal carcinoma (npc), and to provide some suggestions. | 2005 | 16219127 |
| [cpg island methylation of e-cadherin gene promoter in gastric carcinoma]. | transcriptional silencing by cpg island methylation is now believed to be an important mechanism of carcinogenesis. e-cadherin can suppress tumor cell invasion and metastasis, and is considered as an invasion/metastasis suppressor gene. inactivation of e-cadherin gene often occurs in poorly differentiated gastric carcinoma. this study was to investigate the cpg island methylation status of e-cadherin gene promoter in primary human gastric carcinomas and adjacent gastric tissues, and to explore t ... | 2005 | 16219136 |
| [impact of dose boost in skull base on recurrence of stage t4 nasopharyngeal carcinoma]. | the recurrence rate in skull base is high for nasopharyngeal carcinoma (npc) patients with cavernous sinus or/and sphenoid sinus involvement. this study was conducted to explore the impact of dose boost in skull base on the recurrence in skull base and survival of npc patients with cavernous sinus or/and sphenoid sinus involvement. | 2005 | 16219141 |
| [graves' disease in preschool children]. | graves' disease, which is the main cause of hyperthyroidism in the pediatric age group, is very rare in pre-school children. we describe the cases of four girls, aged less than 6 years old, out of a total of 30 patients diagnosed with graves' disease between 1985 and 2004. investigations were motivated by tachycardia, chronic diarrhea, language development delay or thyroid nodules detected by cervical ultrasonography. in three of the four patients height and bone age were advanced. in all patien ... | 2005 | 16219281 |
| phase ii study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: the radioxcape study. | preoperative radiotherapy has been shown to decrease the local recurrence rate of patients with locally advanced rectal cancer. capecitabine and oxaliplatin are both active anticancer agents in the treatment of patients with advanced colorectal cancer and have radiosensitizing properties. therefore, these drugs would be expected to improve effectiveness of preoperative radiotherapy in terms of local control and prevention of distant metastases. | 2005 | 16219623 |
| endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of lung cancer and its impact on surgical staging. | the diagnosis and staging of lung cancer critically depends on surgical procedures. endoscopic ultrasound (eus) -guided fine-needle aspiration (fna) is an accurate, safe, and minimally invasive technique for the analysis of mediastinal lymph nodes (lns) and can additionally detect tumor invasion (t4) in patients with centrally located tumors. the goal of this study was to assess to what extent eus-fna could prevent surgical interventions. | 2005 | 16219935 |
| organ-sparing treatment in muscle-invasive bladder cancer. | organ-sparing treatment of bladder cancer by a trimodality approach is feasible and effective. in this study, the results of a series of patients are reported, who were, in the majority, not suitable for major surgery. | 2005 | 16220401 |
| thyroid function during pregnancy in women with past graves' disease. | graves' disease and thyroid dysfunction during pregnancy can lead to maternal and fetal complications. no information is available on thyroid function in women with a past history of graves' disease. we compared free t3, free t4 and tsh in a group of pregnant women with a history of resolved graves' disease requiring no current treatment (n= 34) and in a group of pregnant controls (n= 102). we found no significant differences in the levels of these hormones between the two groups. women with a p ... | 2005 | 16225580 |
| [indications of the association of radiotherapy and hormonal treatment in prostate cancer]. | rtog and eortc randomised phase iii trials investigated combination of radiation therapy and hormonal treatment in locally advanced prostate cancer t2c-t4 n0-1 m0 (uicc 2002). complete androgen blockade initiated 2 months prior to starting radiotherapy and stopped at the completion of radiotherapy vs radiation therapy alone, increased overall survival in patients with gleason score 2-6. adjuvant androgen suppression started at the end of the radiotherapy and continued indefinitely improved signi ... | 2005 | 16226044 |
| a novel mutation in the monocarboxylate transporter 8 gene in a boy with putamen lesions and low free t4 levels in cerebrospinal fluid. | we describe brain lesions in a patient with a monocarboxylate transporter 8 mutation. imaging showed a high t2 lesion in the left putamen at age 3 and a right putamen lesion at age 6. cerebrospinal fluid free thyroxine concentrations were low, with normal 3,3',5-triiodothyronine concentrations. | 2005 | 16227048 |
| densitometric evaluation of skull and jaw bones after administration of thyroid hormones in rats. | an investigation was performed by use of optical densitometry to observe the effects of different doses of thyroid hormone on bone density of skull and jaw bones and to evaluate the relationship between t3, t4, thyroid stimulating hormone (tsh) serum levels and bone density. | 2005 | 16227474 |
| [transcriptional repression of the trh gene]. | the synthesis and secretion of thyroid hormones (th: t3, t4) must be strictly regulated. th act on their own production via a negative feedback system. the synthesis of thyrotropin-releasing hormone (trh), produced in the hypothalamus, and thyrotropin (tsh) in the pituitary is inhibited at the transcriptional level by th. trh and tsh stimulate production of th. an outstanding, still open, question is the molecular basis of t3-dependent transcription repression of trh and tsh genes. however, some ... | 2005 | 16197903 |
| effects of pregnancy on eating attitudes and disorders: a prospective study. | the aim of this prospective study was to investigate the effects of pregnancy on eating disorders (ed), dietary habits and body image perception. one hundred and fifty pregnant women were interviewed between the period january 2001 and may 2003. ninety-seven women completed the study and were divided in three subgroups: pregnant women with a positive history of dieting (n=37), pregnant women with a positive history of dieting with a complete diagnosis of a current ed (n=11) and pregnant women wi ... | 2005 | 16198191 |
| a phase i/ii study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced t-stage nasopharyngeal carcinoma. | local recurrence is the most common site of failure for locally advanced nasopharyngeal carcinoma (npc) treated with neoadjuvant cisplatin/5-fluorouracil (pf) and definitive radiation at our center. based on this, we studied the addition of chemotherapy during the boost phase of radiation after neoadjuvant pf for advanced t-stage (t3-t4) npc. this strategy was based on theoretical radiosensitization with chemotherapy during accelerated repopulation of the tumor with relatively radioresistant clo ... | 2005 | 16199307 |
| can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for t3-t4 rectal cancer predict for 3-year disease-free survival? | this study set out to determine the impact of a positive circumferential resection margin (crm) (r1-r2) and pathologic downstaging on local recurrence and survival in patients with borderline resectable or unresectable rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy (crt). | 2005 | 16199310 |
| [result analysis of perioperative radiotherapy and laryngeal preservation in hypopharyngeal and pyriform sinus squamous cell carcinoma]. | to evaluate perioperative radiotherapy and laryngeal preservation clinical result of hypopharyngeal pyriform sinus squamous cell carcinoma. | 2005 | 16200964 |
| [contralateral cervical lymph node metastasis in piriform sinus carcinoma]. | to evaluate relative factors affecting contralateral cervical lymph node metastasis in piriform sinus carcinoma. | 2005 | 16200965 |