Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [thyroid function profile in infants submitted to cardiac surgery with cardiopulmonary bypass.]. | cardiac surgery with cardiopulmonary bypass (cpb) is related to euthyroid disease or hypothalamic-pituitary-thyroid system depression. abnormal hemodynamic status induced by cpb is responsible for several endocrine-metabolic changes, triggering complex systemic inflammatory response. this study aimed at evaluating triiodothyronine (t3), tetraiodothyronine (t4) and thyrotrophin (tsh) behavior in infants submitted to cardiac surgery with cpb. | 2004 | 19471741 |
| [evaluation of residual neuromuscular block and late recurarization in the post-anesthetic care unit.]. | residual postoperative paralysis impairs airway patency increasing the risk for postoperative complications. anti-cholinesterase agents improve neuromuscular transmission by acetylcholine build up in the endplate. however, when there is no longer neostigmine effect, 'recurarization' is theoretically possible since the antagonist agent does not displace neuromuscular blocker from its action site. this study aimed at determining the degree of residual neuromuscular block in the post anesthetic car ... | 2004 | 19471760 |
| [accidental subarachnoid steroid injection during chronic lumbar pain treatment: case report.]. | before epidural steroids were used in chronic lumbar pain, subarachnoid injection of these agents was the treatment of choice. although still preconized by some authors, this technique may lead to severe complications with neurological sequelae. this report aimed at describing a case of accidental subarachnoid injection of steroid associated to local anesthetics during epidural puncture to treat lumbar pain. | 2004 | 19471796 |
| carbofuran-induced endocrine disruption in adult male rats. | the objective of this investigation was to determine the acute toxic effects of the carbamate insecticide carbofuran on the levels of endocrine hormones in the serum of male sprague-dawley rats. using chemiluminescent immunoassay, the hormones determined were progesterone, cortisol, estradiol, testosterone, triidothyronine (t3), total thyroxine (total t4), and non-protein-bound thyroxine (free t4). rats exposed to an acute dose of carbofuran (1.5 mg/kg, s.c.) showed the onset of cholinergic sign ... | 2004 | 20021136 |
| prospective phase ii study of preoperative chemoradiation with capecitabine in locally advanced rectal cancer. | capecitabine is an attractive oral chemotherapeutic agent that has a radiosensitizing effect and tumor-selectivity. this study was performed to evaluate the efficacy and toxicity of preoperative chemoradiation therapy, when used with oral capecitabine, for locally advanced rectal cancer. | 2004 | 20368828 |
| screening for thyroid disease | this article focuses on whether it is useful to order a thyroid function test in patients who have no history of thyroid disease and have few or no signs or symptoms of thyroid dysfunction. | 2004 | 20722119 |
| [effects of cysteamine on performances of late--lactating cows during hot summer]. | to investigate the effects of cysteamine compound (lactonin) on milk production of late-lactating cows during hot summer when the temperature humidity index (thi) was higher than 76 and cows were suffered from heat stress. | 2004 | 21158128 |
| [effects of cysteamine on the plasma levels of ss and some metabolic hormones in adult geese]. | to know the effect of cysteamine (cs) on the plasma levels of somatostatin (ss) and some metabolic hormones in adult geese. | 2004 | 21162318 |
| [construction of bifidobacterium infantis/cd tumor targeting gene therapy system.] | background: to construct the bifidobacterium infantis/cd tumor targeting gene therapy system. methods: pcr expanded cd gene and pgex-1lambdat plasmid was transferred into e.coli. jm109. with tss solution. then a dual restriction enzyme (ecor i and bamh i) digestion was carried out to cut cd gene and pgex-1lambdat plasmid. two segments (4.9 kb and 1.3 kb) were selected and extracted from the gel. t4 dna ligase was added to these two segments' mixture. finally, reconstruction fragment was transfer ... | 2004 | 21214999 |
| [the heterogeneous nuclear ribonucleoprotein a2/b1 expression in non-small cell lung cancer and its clinical significance.] | background: to investigate the expression features of the heterogeneous nuclear ribonucleoprotein a2/b1 (hnrnp a2/b1) in non-small cell lung cancer and its clinical significance. methods: hnrnp a2/b1 expression of cancer tissues, paracancerous lung tissues, resected bronchial stump epithelium tissues was detected in 58 non-small cell lung cancer patients and pulmonary tissues in 30 patients with benigh pulmonary lesions as control by immunohistochemistry methods. results: the positive expressive ... | 2004 | 21215000 |
| [expression of cox-2 and its prognostic significance in non-small cell lung cancer.] | background: to investigate the expression of cox-2 and its relation to clinical pathophysiological features and prognosis in non-small cell lung cancer (nsclc). methods: the expression of cox-2 protein was detected in 52 nsclc tissues by immunohistochemical (s-p) method. results: the positive cox-2 expression was observed in 25 (48.1%) cases of nsclc tissues. the positive rate of cox-2 expression was 76.5% and 34.3% in adenocarcinoma and squamous cell carcinoma respectively (p < 0.01). the posit ... | 2004 | 21215004 |
| [surgical treatment of lung cancer by video-assisted thoracoscopic surgery.] | background: to investigate the role of curative and palliative surgical treatment of lung cancer with video-assisted thoracoscopic surgery (vats). methods: forty-three patients with lung cancer were prescribed operations with vats, which included 5 cases of stage ia, 14 cases of ib, 1 case of iia, 4 cases of iib, 7 cases of iiia, 6 cases of t4-iiib and 6 cases of iv. the 7 patients of stage iiia were previously staged as n0 before operation, but reevaluated as n2-iiia after operation. there were ... | 2004 | 21244798 |
| incidence of vertebral deformities in 255 female rheumatoid arthritis patients measured by morphometric x-ray absorptiometry. | to date, no studies have been published on incident deformities in patients with rheumatoid arthritis (ra). morphometric x-ray absorptiometry (mxa) is an alternative to conventional x-rays for identifying vertebral deformities. the aim of the present study was to describe the incidence of vertebral deformities in 255 female ra patients measured by mxa, and the relationship between incident deformities and clinical and demographic variables. mxa is still under evaluation for its ability to identi ... | 2005 | 15197538 |
| [autopsy case of lewy body dementia associated with abundant argyrophilic grains]. | we report an autopsy case showing neuropathologically abundant lewy bodies and argyrophilic grains. a japanese woman without hereditary burden developed parkinsonian gait at the age of 74, following by insomnia, memory disturbance, delirium, resting tremor, rigidity, and retropulsion. about 8 months later, a visual hallucination, concerning small worms, children, and so on, became obvious. about 16 months later, malignant lymphoma was detected. about 17 months later, she died of pneumonia. the t ... | 2005 | 16146214 |
| thoracic epidural anesthesia (tea) with 0.2% ropivacaine in combination with ipsilateral brachial plexus block (bpb) for modified radical mastectomy (mrm). | breast cancer is the 2nd most common tumors in thai women. until now, oncologic breast surgeries are typically performed by general anesthesia (ga). however, ga cannot provide adequate postoperative pain control and routine use of parenteral opioids aggravate postoperative sedation, nausea, emesis, impaired oxygenation and depressed ventilation. thoracic epidural anesthesia (tea) is one of the regional anesthetic techniques that can be done by using a low dose of local anesthetic in combination ... | 2005 | 16146257 |
| current methodology to assess bioequivalence of levothyroxine sodium products is inadequate. | levothyroxine sodium is a drug with a narrow therapeutic index for which an individual patient must have his or her dose carefully titrated to achieve the necessary therapeutic effect. in addition, exogenous levothyroxine cannot be distinguished from the endogenously produced hormone. since 2004, generic formulations have been approved for the most frequently prescribed brands of levothyroxine sodium. this review examines the methodology and statistical acceptance criteria and summarizes finding ... | 2005 | 16146348 |
| management of contralateral n0 neck in tonsillar squamous cell carcinoma. | it is well established that tonsillar squamous cell carcinomas have a high probability of disseminating to the neck. an ipsilateral neck treatment is mandatory during initial treatment of stages ii to iv tonsillar carcinomas. however, as of yet, no consensus exists whether to perform elective contralateral neck management. | 2005 | 16148715 |
| the reliability of lymph-node staging in rectal cancer after preoperative chemoradiotherapy. | to determine the prognostic significance of the nodal stage and number of nodes recovered in the surgical specimen after preoperative synchronous chemoradiation (scrt) and surgery for locally advanced or unresectable rectal cancer. | 2005 | 16149289 |
| [total thyroxine (t4), free thyroxine (ft4)]. | 2005 | 16149503 | |
| [the effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report]. | electroconvulsive therapy (ect) is an effective treatment of severe depression but its mechanism of action is still unknown. the aim of the study was to investigate the effect of first ect on serum hormone concentrations in patients with severe depression. | 2005 | 16149757 |
| intensity-modulated radiation therapy for the treatment of nonanaplastic thyroid cancer. | intensity-modulated radiation therapy (imrt) enables highly conformal treatment for thyroid cancer (tc). in this study, we review outcomes/toxicity in a series of tc patients treated with imrt. | 2005 | 16154712 |
| [breast cancers associated with pregnancy. about two cases]. | the association between breast cancer and pregnancy is a rare but not exceptional. the authors reports two cases of patients aged 29 and 30 years respectively. both patients had single pregnancis. the first patient, third delivery, had a gestational age of 30 weeks of amenorrhea and a stadify t 3nim0. the second patent was second delivery and had during her first prenatal consultation at 38 weeks of amenorrhea a developing but not extending statify t4. cytology suggest the diagnosis whicle was c ... | 2005 | 16156417 |
| activity-based in vitro selection of t4 dna ligase. | recent in vitro methodologies for selection and directed evolution of proteins have concentrated not only on proteins with affinity such as single-chain antibody but also on enzymes. we developed a display technology for selection of t4 dna ligase on ribosome because an in vitro selection method for dna ligase had never been developed. the 3' end of mrna encoding the gene of active or inactive t4 dna ligase-spacer peptide fusion protein was hybridized to dsdna fragments with cohesive ends, the s ... | 2005 | 16157309 |
| response of ch4 emission of paddy fields to land management practices at a microcosmic cultivation scale in china. | the terrestrial ecosystem may be either a source or a sink of ch4 in rice paddies, depending, to a great extent, on the change of ecosystem types and land use patterns. ch4 emission fluxes from paddy fields under 4 cultivation patterns (conventional plain culture of rice (t1), no-tillage and ridge culture of rice (t2), no-tillage and ridge culture of rice and wheat (t3), and rice-wheat rotation (t4)) were measured with the closed chamber technique in 1996 and 1998 in chongqing, china. the result ... | 2005 | 16158607 |
| [quality of life in patients after radical prostatectomy]. | according to the literature, after radical prostatectomy the patients had normal micturition and erectile function in 50 and 10-30%, respectively. a total of 647 patients with diagnosis prostatic cancer (pc) stage t1a-t4 were examined in two clinics in 1997-2003. of them, 43 patients (pc stage t1a-t3a) have undergone retropubic radical prostatectomy (rrp) by a modified nerve-preserving technique (preservation of the urinary bladder neck, puboprostatic joints in prostate size > 60 cm). preoperati ... | 2005 | 16158742 |
| p53 expression in small cell carcinoma of the urinary bladder: biological and prognostic implications. | small cell carcinoma of the urinary bladder is a rare and highly aggressive tumor. p53 expression has been shown to be associated with poor prognosis in a variety of tumors. this study was undertaken to investigate p53 expression in a large series of small cell carcinomas of the urinary bladder and to correlate the findings with clinicopathologic parameters and clinical outcome. pathologic findings were reviewed and were correlated with clinical findings and follow-up information. immunohistoche ... | 2005 | 16158936 |
| [expression and clinical significance of cd1a+ dendritic cells in glottic squamous cell carcinoma]. | dendritic cells (dcs) are the most important antigen-presenting cells. cd1a, a marker of immature dcs, plays a role in tumorigenesis. this study was designed to explore the correlation of cd1a(+) dcs to pathologic degree, t stage, local recurrence, and prognosis of glottic squamous cell carcinoma. | 2005 | 16159438 |
| randomized controlled trial of an educational intervention for managing fatigue in women receiving adjuvant chemotherapy for early-stage breast cancer. | to evaluate the efficacy of a psychoeducational intervention in improving cancer-related fatigue. | 2005 | 16135471 |
| ultrastructural changes in rat livers perfused in vitro and in vivo with a high dose of methotrexate. | methotrexate is an antifolate that is widely used in the treatment of malignant tumours and other diseases. the present study was undertaken to examine the short-term effects of high doses of methotrexate (hd-mtx) on the ultrastructure and metabolic activity of isolated rat livers. the authenticity of the drug-induced changes was substantiated by the concomitant use of in vivo experiments. isolated rat livers were infused with hd-mtx via the portal vein for 3 hours (total dose for each liver 200 ... | 2005 | 16136496 |
| a rational approach to pulmonary screening in newly diagnosed head and neck cancer. | the purpose of this study was to determine the detection rate of lung metastasis or a synchronous lung primary tumor in patients with newly diagnosed head and neck mucosal squamous cell carcinoma (scc) and to determine factors that are associated with positive findings. | 2005 | 16136584 |
| clinical investigation: thyroid function test abnormalities in cardiac arrest associated with acute coronary syndrome. | it is known that thyroid homeostasis is altered during the acute phase of cardiac arrest. however, it is not clear under what conditions, how and for how long these alterations occur. in the present study we examined thyroid function tests (tfts) in the acute phase of cardiac arrest caused by acute coronary syndrome (acs) and at the end of the first 2 months after the event. | 2005 | 16137355 |
| assessment of serum catecholamine concentrations in patients with pheochromocytoma undergoing videolaparoscopic adrenalectomy. | we analyzed the changes in serum catecholamine concentrations, i.e. adrenaline and noradrenaline, in response to surgical stress in patients with pheochromocytoma who undergone videolaparoscopic adrenalectomy. | 2005 | 16137397 |
| a modified cdna subtraction to identify differentially expressed genes from plants with universal application to other eukaryotes. | we have designed a simple and efficient polymerase chain reaction (pcr)-based cdna subtraction protocol for high-throughput cloning of differentially expressed genes from plants that can be applied to any experimental system and as an alternative to dna chip technology. sequence-independent pcr-amplifiable first-strand cdna population was synthesized by priming oligo-dt primer with a defined 5' heel sequence and ligating another specified single-stranded oligonucleotide primer on the 3' ends of ... | 2005 | 16137632 |
| clinical and epidemiological features of oral cancer in a medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases. | description of clinical and epidemiological characteristics of patients who underwent surgery for oral cancer in a medical school teaching hospital, and determination of differences with respect to other institutions and/or periods of time. | 2005 | 16138235 |
| bladder cancer with obstructive uremia: oncologic outcome after definitive surgical management. | to report the surgical and oncologic outcomes of patients with bladder cancer who present with obstructive uremia. | 2005 | 16140072 |
| a four-dimensional structure of t4 infection. | 2005 | 16142226 | |
| therapeutic efficacy of zinc sulphate used in clustered model treatment in alleviating zinc deficiency in cattle and its effect on hormones, vitamins and production parameters. | a survey was conducted in 10 districts of northern india. significant deficiency of zinc was observed in soil, fodders and (cattle) serum samples. the animals showed typical signs of zinc deficiency, namely stiff gait, swelling of hocks and knees, subcutaneous fluid accumulation, rough coat, etc. of variable intensity. a clustered model therapeutic trial was conducted and zinc-deficient cattle were divided into three groups. group a was provided with mineral mixture containing zinc sulphate. gro ... | 2005 | 16142608 |
| polyarticular corticosteroid injection versus systemic administration in treatment of rheumatoid arthritis patients: a randomized controlled study. | to study the effectiveness and side effects of polyarticular corticosteroid injection compared to systemic administration in patients with rheumatoid arthritis (ra), and to examine the differential response to injection among joints. | 2005 | 16142862 |
| the multidisciplinary rectal cancer treatment: main convergences, controversial aspects and investigational areas which support the need for an european consensus. | during the past decades staging and treatment of rectal cancer are used different in europe and in north america. to promote a process to integrate the daily practice with the best evidence of the literature an international conference was organized in italy. agreement between experts, centres, and specialists who participated in the conference are reported. | 2005 | 16165238 |
| medullary thyroid carcinoma arises in the absence of prolactin signaling. | prolactin, a pituitary hormone, exerts pleiotropic effects in various cells. these effects are mediated by a membrane receptor highly expressed in many tissues. to analyze prolactin effects on the thyroid gland, we first identified prolactin receptor (prlr) mrnas by in situ hybridization. to further evaluate the physiologic relevance of prlr actions in the thyroid in vivo, we used prlr knockout mice. whereas the histologic structure of thyroid of prlr-null mice was not disturbed, we show that t4 ... | 2005 | 16166330 |
| periplasmic domains define holin-antiholin interactions in t4 lysis inhibition. | bacteriophage t4 effects host lysis with a holin, t, and an endolysin, e. t and e accumulate in the membrane and cytoplasm, respectively, throughout the period of late gene expression. at an allele-specific time, t triggers to disrupt the membrane, allowing e to enter the periplasm and attack the peptidoglycan. t triggering can be blocked by secondary infections, leading to the state of lysis inhibition (lin). lin requires the t4 antiholin, ri, and is sensitive to the addition of energy poisons. ... | 2005 | 16166524 |
| the role of the sternum, costosternal articulations, intervertebral disc, and facets in thoracic sagittal plane biomechanics: a comparison of three different sequences of surgical release. | eighteen human torsos were used in three experiments (a, b, and c) to determine the changes in sagittal motion due to three different sequences of three surgical releases. | 2005 | 16166888 |
| changes in intraocular pressure and corneal and retinal nerve fiber layer thicknesses in hypothyroidism. | to evaluate the changes in intraocular pressure (iop), corneal thickness (ct), and retinal nerve fiber layer thickness (rnflt) in patients with hypothyroidism before and after treatment. | 2005 | 16167286 |
| prognostic value of tumor regression evaluated after first course of radiotherapy for anal canal cancer. | to evaluate whether the tumor response after an initial course of irradiation predicts for colostomy-free survival and overall survival in patients with anal canal cancer. | 2005 | 16169674 |
| thyroid hormones and fetal brain development. | thyroid hormones are intricately involved in the developing fetal brain. the fetal central nervous system is sensitive to the maternal thyroid status. critical amounts of maternal t3 and t4 must be transported across the placenta to the fetus to ensure the correct development of the brain throughout ontogeny. severe mental retardation of the child can occur due to compromised iodine intake or thyroid disease. this has been reported in areas of the world with iodine insufficiency, new guinea, and ... | 2005 | 16170282 |
| [comparison of the osteogenic activity of bone morphogenetic protein (bmp) mutants]. | modification of the heparin binding site by alteration of the amino acid sequence of bone morphogenetic protein-2 (bmp-2) results in a change in the local retention time. the purpose of this study was to compare the osteogenic activity of t3 and t4, two mutants with increased binding capacity to heparin, and b2gdf-5 a mutant resulting from the fusion of the n-terminal amino acid sequence of bmp-2 and the c-terminal sequence of gdf-5 with wild-type bmp-2 in vivo. | 2005 | 16170576 |
| efficacy and toxicity of fluorouracil, doxorubicin, and cisplatin/nedaplatin treatment as neoadjuvant chemotherapy for advanced esophageal carcinoma. | patients with advanced esophageal carcinoma including clinical t4 tumor, extensive lymph node metastasis, or intramural metastasis have a dismal prognosis, despite recent multimodality treatments. the aim of this study was to evaluate the efficacy and toxicity of neoadjuvant chemotherapy using fluorouracil, doxorubicin, and cisplatin or nedaplatin (fap/n) in these patients. | 2005 | 16170897 |
| assessing the quality of colorectal cancer staging: documenting the process in improving the staging of node-negative colorectal cancer. | examination of 14 or more nodes is the optimal criterion to accurately stage node-negative colorectal cancer and predict outcome. | 2005 | 16172297 |
| analysis of t-cell receptor gene rearrangement for predicting clinical outcome in patients with cutaneous t-cell lymphoma: a comparison of southern blot and polymerase chain reaction methods. | to extend previous observations regarding the prognostic value of analyzing lymph node dna from patients with cutaneous t-cell lymphoma for the presence of a monoclonal t-cell population by southern blot vs polymerase chain reaction (pcr) methods. | 2005 | 16172307 |
| thyroid hormone concentrations, disease, physical function, and mortality in elderly men. | physiological changes in thyroid hormone concentrations might be related to changes in the overall physical function in the elderly. | 2005 | 16174720 |
| cd10 expression in colorectal carcinoma correlates with liver metastasis. | if it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis. | 2005 | 16175325 |
| cold adaptation and thyroid hormone metabolism. | resting oxygen consumption and energy expenditure is sensitive to slight alterations in thyroid function. this means that timing and magnitude of cold adaptation would to some extent depend on thyroid function. local thyroid hormone metabolism is important for energy expenditure and dissipation of heat in special tissues. recruitment of brown adipocytes and upregulation of uncoupling protein 1 in mitochondria depends on high tissue t3 concentrations. most of this t3 is derived from local 5' deio ... | 2005 | 16175491 |
| effects of recombinant human thyrotropin on heart rate variability and blood pressure in patients on l-thyroxine-suppressive therapy for differentiated thyroid carcinoma. | recombinant human thyrotropin (rhtsh) is now currently used for the follow-up of patients with differentiated thyroid carcinoma (dtc) after total thyroid ablation. side effects after rhtsh could involve the autonomic system and tsh receptors are possibly expressed in the heart and coronary arteries. | 2005 | 16179790 |
| region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. | the aim of this study was to determine whether changes in the circulating thyroid hormone (th) and brain synaptosomal th content affected the relative levels of mrna encoding different thyroid hormone receptor (tr) isoforms in adult rat brain. northern analysis of polya+rna from cerebral cortex, hippocampus and cerebellum of control and hypothyroid adult rats was performed in order to determine the relative expression of all tr isoforms. circulating and synaptosomal th concentrations were determ ... | 2005 | 16180094 |
| clinical evaluation of low-dose cisplatin and 5-fluorouracil as adjuvant chemoradiotherapy for advanced squamous cell carcinoma of the esophagus. | the aim of this retrospective study was to evaluate the effectiveness of low-dose cisplatin and 5-fluorouracil (low-dose fp) as an adjuvant chemoradiotherapy for resected advanced squamous cell carcinoma of the esophagus. from 1994 to 1999, 57 patients who showed an invasion of the tumor over the muscularis propria (t2-t4), regional lymph node metastasis (n1), and no distant metastasis (m0) were enrolled in this analysis. postoperative chemoradiotherapy (crt group) was performed on 14 of the pat ... | 2005 | 16180698 |
| thyroid function and morphology in patients affected by williams syndrome. | to evaluate the prevalence of abnormalities of thyroid function and morphology in a cohort of patients with williams syndrome (ws). | 2005 | 16181239 |
| high-dose-rate endorectal brachytherapy in the treatment of locally advanced rectal carcinoma: technical aspects. | in this era of new radiation technologies and tumor imaging, a high-dose-rate endorectal brachytherapy has been developed and tested in a phase i/ii study of advanced rectal tumors. in this article, we report technical aspects of the treatment modality. | 2005 | 16182224 |
| comparison of three different epidural solutions in off-pump cardiac surgery: pilot study. | immediate extubation using thoracic epidural analgesia (tea) has become more popular after off-pump coronary artery bypass grafting (opcab). in this randomized prospective double-blind study, we present the first comparison of preoperative and postoperative haemodynamics during different regimens of tea for immediate extubation after cardiac surgery. | 2005 | 16183682 |
| [thyroid disorders in diabetic patients]. | to evaluate thyroid function and morphology in all diabetic outpatients from our institution. | 2005 | 16184251 |
| [dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-walker mammary carcinoma]. | the hypothalamus-pituitary-thyroid axis was studied in rats with the "low t(3) syndrome" caused by the implantation of the walker-256 mammary carcinoma. male adult rats were injected s.c. with 1 x 106 viable tumoral cells and killed 10 days later. the tumor development was associated with decreased thyroid activity characterized by a approximately 15% reduction in the nuclear area of the thyrocytes and 131i-thyroid uptake (down by approximately 50%), as well as about 70% lower serum levels of t4 ... | 2005 | 16184254 |
| hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma. | a 26-year-old pregnant woman presenting with repeated episodes of vaginal bleeding, weight loss, and shortness of breath was diagnosed with choriocarcinoma with metastases to both lungs. chorionic gonadotropin levels (hcg) were >2.5 x 10(6)mu/ml. consistent with hcg-induced subclinical hyperthyroidism, she had a suppressed tsh of 0.037 mu/l (0.49 - 4.67), a t4 of 18.1 microg/dl (4.9 - 10.7), and t3 of 136 ng/dl (45 - 137). chemotherapy with a combined regimen with etoposide, methotrexate, and da ... | 2005 | 16184264 |
| increasing the length of the single-stranded overhang enhances unwinding of duplex dna by bacteriophage t4 dda helicase. | dda has been shown previously to be active as a monomer for dna unwinding [nanduri et al. (2002) proc. natl. acad. sci. u.s.a. 99, 14722] and streptavidin displacement [byrd and raney (2004) nat. struct. mol. biol. 11, 531]. however, its activity for streptavidin displacement increased as a function of the length of single-stranded dna. we investigated whether dda exhibited enhanced dna unwinding of partially duplex dna substrates as a function of increasing the length of the single-stranded ove ... | 2005 | 16185067 |
| the use of nonnatural nucleotides to probe the contributions of shape complementarity and pi-electron surface area during dna polymerization. | it is widely accepted that the dynamic behavior of dna polymerases during translesion dna synthesis is dependent upon the nature of the dna lesion and the incoming dntp destined to be the complementary partner. we previously demonstrated that 5-nitro-1-indolyl-2'-deoxyribose-5'-triphosphate, a nonnatural nucleobase possessing enhanced base-stacking abilities, can be selectively incorporated opposite an abasic site (reineks, e. z., and berdis, a. j. (2004) biochemistry 43, 393-404.). while the en ... | 2005 | 16185078 |
| a potential chemotherapeutic strategy for the selective inhibition of promutagenic dna synthesis by nonnatural nucleotides. | this manuscript reports the development of nonnatural nucleotide analogues that are preferentially incorporated opposite an abasic site, a common form of dna damage. competition experiments confirm that all of the nonnatural nucleotides tested are poorly incorporated into unmodified dna. however, two analogues that contain extensive pi-electron density (5-nitro-indolyl-2'deoxyriboside triphosphate (5-nitp) and 5-phenyl-indolyl-2'deoxyriboside triphosphate (5-phitp)) are selectively inserted oppo ... | 2005 | 16185079 |
| an artificial activator that contacts a normally occluded surface of the rna polymerase holoenzyme. | many activators of transcription are sequence-specific dna-binding proteins that stimulate transcription initiation through interaction with rna polymerase (rnap). such activators can be constructed artificially by fusing a dna-binding protein to a protein domain that can interact with an accessible surface of rnap. in these cases, the artificial activator is directed to a target promoter bearing a recognition site for the dna-binding protein. here we describe an artificial activator that functi ... | 2005 | 16185714 |
| [effects of endoscopic sympathicotomy in carotid and vertebral arteries in the surgical treatment of primary hyperhidrosis]. | analyze, in patients with primary hyperhidrosis (ph) who was undergone to videothoracoscopic sympathicotomy, the degree of vascular denervation after surgical transection of the thoracic sympathetic chain by measuring ultrasonografic parameters in carotid and vertebral arteries. | 2005 | 16186983 |
| naturally occurring mutations in the thyroglobulin gene. | thyroglobulin (tg) is a large glycoprotein dimer secreted into the follicular lumen. it serves as the matrix for the synthesis of thyroxine (t4) and triiodothyronine (t3), and the storage of thyroid hormone and iodide. in response to demand for thyroid hormone secretion, tg is internalized into the follicular cell and digested in lysosomes. subsequently, the thyronines t4 (approximately 80%) and t3 (approximately 20%) are released into the blood stream. biallelic mutations in the tg gene have be ... | 2005 | 16187910 |
| intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. | intrathecal clonidine (itc) is used clinically to manage neuropathic pain but frequently causes hypotension and bradycardia due to centrally mediated sympatholytic effects. | 2005 | 16188594 |
| patient characteristics rather than the type of dialyser predict the variability of endothelial derived surface molecules in chronic haemodialysis patients. | cardiovascular disease (cvd) is a frequent complication in chronic haemodialysis (hd) patients. endothelial dysfunction, as measured by soluble cellular adhesion molecules (scam) and von willebrand factor (vwf) in plasma, is an early manifestation of cvd. today, it is unknown if, and to what extent, their levels are influenced by the type of dialyser. | 2005 | 16188898 |
| increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type i deiodinase activity. | marked changes in peripheral thyroid hormone metabolism occur in critical illness, resulting in low serum t3 and high rt3 levels. in this study, we investigated whether t4s levels are increased in patients who died after intensive care and whether t4s levels are correlated with liver type i deiodinase (d1) or sulfotransferase (sult) activity. | 2005 | 16189257 |
| structure and dynamics of the triplet state of oligothiophenes in isotropic and partially oriented matrices. | the photoexcited triplet states of 4,4'-dipentoxy-2,2'-dithiophene (4-t2), 3,3'-dipentoxy-2,2'-dithiophene (3-t2), and 4,4'''-dipentoxy-2,2':5',2'':5'',2'''-tetrathiophene (4-t4) have been investigated by time-resolved electron paramagnetic resonance in glassy toluene and in a frozen oriented liquid crystal, which provides a partially ordered medium. the preferential orientation of the rod-like 4-t2 and 4-t4 is compared to that of the disk-like 3-t2. the use of an oriented matrix coupled to simp ... | 2005 | 16189608 |
| [changes of cell adhesion molecules and proinflammatory cytokines during cardiopulmonary bypass and the effect of intervention]. | to investigate the changes of the cell adhesion molecules and proinflammatory cytokines during cardiopulmonary bypass, and to observe the effect of intervention with ulinastatin. | 2005 | 16190387 |
| elevated thyroid indices in children and adolescents with obsessive-compulsive disorder: effects of clomipramine treatment. | to examine the basal thyroid function in pediatric obsessive compulsive disorder (ocd) versus controls, and to explore the relation between baseline thyroid measures and response to clomipramine treatment, and the effects of treatment on thyroid hormones. | 2005 | 16190790 |
| topographic anatomy of bronchial arteries in the pig: a corrosion cast study. | the anatomy of porcine bronchial circulation has not been fully described. the purpose of this study was to investigate the extrapulmonary topographic anatomy of bronchial arteries in pig. ten pigs weighing 15-25 kg were studied. between one and four bronchial arteries were found in each pig. the bronchoesophageal artery (bea), tracheobronchial artery (tba), inferior bronchial artery (iba) and accessory bronchial artery (aba) were present in 10/10, 8/10, 6/10 and 2/10 animals, respectively. the ... | 2005 | 16191170 |
| hypotensive spinal cord infarction associated with vertebral body infarction after treatment with short-acting antihypertensive agent. | spinal cord infarction is a rare condition with heterogeneous causes. an 80-year-old diabetic woman was brought to the emergency department because of retrosternal pain and high blood pressure. twenty minutes after treatment with sublingual nitroglycerin and short-acting oral antihypertensive agent, blood pressure had dropped from 201/91 mm hg to 158/68 mm hg, followed by abrupt onset of weakness in lower limbs, urinary retention and sensory loss in bilateral t4-l1 levels and the left lower limb ... | 2005 | 16193186 |
| prevalence of thyroid autoimmunity in patients with pemphigus vulgaris. | among bullous diseases, pemphigus vulgaris (pv) is a classical variety of this type of skin disorders. to establish the real prevalence of thyroid abnormalities in such a disease, a prospective study was developed. for this reason, thyroid evaluation was performed in 15 consecutive patients who attended the dermatology clinic for pv and in a group of 15 healthy volunteers (control group) matched by age and gender. thyroid function was evaluated by measuring t3, t4 and tsh. the presence or absenc ... | 2005 | 16193707 |
| clinico-pathological features of bladder carcinoma in women in pakistan and smokeless tobacco as a possible risk factor. | bladder carcinoma is one of the common urological malignancies occurring worldwide in both sexes. use of smokeless tobacco by women is common in rural areas of pakistan. the clinico-pathological features of bladder carcinoma in women and association of smokeless tobacco as a possible risk factor for bladder carcinoma has not been well described in the literature. the objective of the study was to determine the clinico-pathological features of histologically confirmed bladder carcinoma in women a ... | 2005 | 16083498 |
| social inhibition of seasonal fattening in wild and captive gray mouse lemurs. | due to their differential reproductive investment, males and females often exhibit high differences in energy management. the main hypothesis tested in this study is that short photoperiod-induced fattening in the small primate microcebus murinus is strongly affected by social cues. short photoperiod-induced changes in body mass, lean mass and thyroid hormone t4 plasma levels measurements were investigated in wild and captive animals. individual housing showed that both males and females are abl ... | 2005 | 16085129 |
| neoadjuvant chemotherapy for squamous cell carcinoma of the oral tongue in young adults: a case series. | squamous cell carcinoma of the oral tongue (sccot) in the young population has emerged as a growing worldwide health problem. standard therapies, consisting primarily of surgery with possible adjuvant radiotherapy, have resulted in only modest improvements in survival in recent decades, whereas the treatments for sccot continue to impair oral function. with the increased use and improved functional results of neoadjuvant chemotherapy in the treatment of squamous cell carcinoma of other upper aer ... | 2005 | 16086413 |
| t4 sympathectomy for palmar hyperhidrosis: an effective approach that simultaneously minimzes compensatory hyperhidrosis. | compensatory hyperhidrosis (ch) is the most troublesome side effect after t2 sympathectomy for palmar hyperhidrosis (ph). the aim of this study was to evaluate whether t4 ganglion interruption for ph is an effective approach that can simultaneously minimize the rate of ch. between july 2001 and july 2003, 84 ph patients undergoing bilateral thoracoscopic t4 sympathectomy were followed up in the outpatient clinic and by telephone questionnaire. rates of success, regret, ch, recurrence, and compli ... | 2005 | 16089308 |
| children with differentiated thyroid cancer achieve adequate hyperthyrotropinemia within 14 days of levothyroxine withdrawal. | the preparation for radioiodine administration recommended by the current pediatric literature is a 6-wk withdrawal that typically includes the transient administration of t3. compared with adults, t4 clearance rates and serum tsh to free t4 ratios are higher in children, implying that pediatric patients can achieve adequate hyperthyrotropinemia with shorter levothyroxine withdrawals. | 2005 | 16091480 |
| spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating leptin in obese premenopausal women. | recent evidence implicates leptin as an important modulator of thyroid axis activity. | 2005 | 16091498 |
| qeeg changes during carotid clamping in carotid endarterectomy: spectral edge frequency parameters and relative band power parameters. | intraoperative monitoring is needed to identify accurately those patients in need of a shunt during carotid endarterectomy. eeg can be used for this purpose, but there is no consensus on the variables to use. using a database consisting of 149 eegs recorded from patients during carotid endarterectomy under isoflurane (n=61) or propofol (n=88) anesthesia and who did or did not receive a shunt, the authors investigated which of 16 derivations (common reference, cz) and 12 parameters (relative and ... | 2005 | 16093896 |
| effectiveness of lymphoscintigraphic sentinel node detection for cervical staging of patients with squamous cell carcinoma of the head and neck. | to evaluate the feasibility and staging ability of the sentinel node (sn) technique for patients with squamous cell carcinoma of the oral cavity or oropharynx and clinically negative necks. this prospective study compares the histopathologic status of the sn with that of the remaining neck dissection tissues. | 2005 | 16094574 |
| risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy. | the objective of this study was to define different prognostic groups with regard to locoregional control (lrc) derived from recursive partitioning analysis (rpa). | 2005 | 16130134 |
| breast carcinoma with noninflammatory skin involvement (t4b): time to abandon an historic relic from the tnm classification. | in this study, the authors evaluated the clinical presentation of patients with t4b breast carcinoma, analyzed the impact of noninflammatory skin involvement on long-term survival, and addressed the question whether the t4 tumor category still has any justification. | 2005 | 16130140 |
| role of cd97(stalk) and cd55 as molecular markers for prognosis and therapy of gastric carcinoma patients. | to explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of cd97 and its cellular ligand cd55 in gastric carcinomas. | 2005 | 16130195 |
| cellular and structural biology of the deiodinases. | the three iodothyronine deiodinases catalyze the initiation (d1, d2) and termination (d3) of thyroid hormone effects in vertebrates. a recently conceived three-dimensional model predicts that these enzymes share a similar structural organization and belong to the thioredoxin (trx) fold superfamily. their active center is a selenocysteine- containing pocket defined by the beta1-alpha1-beta2 motifs of the trx fold and a domain that shares strong similarities with the active site of iduronidase, a ... | 2005 | 16131321 |
| the role of deiodinases in amphibian metamorphosis. | valerie galton's prediction over 40 years ago that deiodinases would be important in amphibian metamorphosis has been confirmed. expression of iodothyronine deiodinase type 2 (d2) and type 3 (d3) occurs in embryogenesis at relevant locations long before the thyroid gland has developed. the expression of d2, an enzyme that synthesizes the active hormone triiodothyronine (t3) from its circulating precursor thyroxine (t4), accurately marks cells at the time that they undergo thyroid hormone-depende ... | 2005 | 16131324 |
| reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study. | subclinical hyperthyroidism has been reported to affect systolic and diastolic cardiac function. however, the reversibility of these effects is not well established. | 2005 | 16131580 |
| inhibition of pituitary type 2 deiodinase by reverse triiodothyronine does not alter thyroxine-induced inhibition of thyrotropin secretion in hypothyroid rats. | intrapituitary triiodothyronine (t3) production plays a pivotal role in the control of tsh secretion. its production is increased in the presence of decreased serum thyroxine (t4) concentrations and the enzyme responsible, deiodinase type 2 (d2), is highest in hypothyroidism. in order to document the role of this enzyme in adult rats we developed an experimental model that inhibited this enzyme using the specific inhibitor, reverse t3 (rt3). | 2005 | 16131606 |
| plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. | the present study was designed to investigate the relations between plasma ghrelin concentrations, eating patterns, and circulating concentrations of cortisol and thyroid hormones in women with anorexia nervosa, bulimia nervosa, and binge-eating disorder. the patterns of disordered eating behavior were assessed using the eating attitudes test (eat-26) and the bulimia test-revised (bulit-r). in women with eating disorders, but not in healthy control women, plasma ghrelin concentrations were negat ... | 2005 | 16131812 |
| [vertebral body replacement with synex in combined posteroanterior surgery for treatment of thoracolumbar injuries]. | reduction and stabilization of unstable spinal injuries with reconstruction of the anterior column resulting in a permanent restitution of the physiologic spinal alignment, stability and load-bearing capacity. | 2005 | 16132250 |
| optimal ligation level of the primary feeding artery and bowel resection margin in colon cancer surgery: the influence of the site of the primary feeding artery. | in colon cancer surgery, it is recommended that en bloc resection involving extended lymphadenectomy, characterized as a hemicolectomy, be performed by ligating the primary feeding artery at a high position and resecting proximal and distal with 5-cm to 10-cm bowel margins. however, there is little evidence to unequivocally support such extensive lymphovascular resection. | 2005 | 16132477 |
| incidence and clinical impact of sterilized disease and minimal residual disease after preoperative radiochemotherapy for rectal cancer. | in advanced rectal cancer, chemoradiation can induce downstaging until complete disappearance of the tumor or its persistence in minimal form. the complete sterilized and the minimal residual disease often are considered similar. we evaluated the specific incidence of these two conditions and analyzed their impact in terms of local recurrence, distant metastasis, and survival. | 2005 | 16132481 |
| [endosonographic imaging of tumor thickness in oral squamous cell cancer and its effect on the incidence of lymph node metastases]. | the correlation between increasing tumor thickness and lymph node metastases as well as reduced survival in oral cancer has been proven by several studies. in most investigations the tumor thickness was assessed in histological sections. the aim of our prospective study was to assess tumor thickness in oral squamous cell carcinoma (oscc) by intraoral ultrasonography and to evaluate the predictive value of tumor thickness for incidence of cervical lymph node involvement and survival. | 2005 | 16133281 |
| the mono-adp-ribosyltransferases alt and modb of bacteriophage t4: target proteins identified. | infection of escherichia coli by bacteriophage t4 leads to the expression of three phage mono-adp-ribosyltransferases (namely, alt, moda, and modb), each of which modifies a distinct group of host proteins. to improve understanding of these interactions and their consequences for the t4 replication cycle, we used high-resolution two-dimensional gel electrophoresis and mass-spectrometry to identify some of the putative target proteins adp-ribosylated in vitro by alt (total approximately 27) and m ... | 2005 | 16112649 |
| molecular evolution and multilocus sequence typing of 145 strains of sars-cov. | in this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of sars-cov available in the ncbi genbank. one hundred and seventy-four of these sites existed in two or more sars-cov genome sequences. according to the sequence polymorphism, all sars-covs can be divided into three groups: (i) group 1, animal-origin viruses (such as sars-cov sz1, sz3, sz13 and sz16); (ii) group 2, all viruses with clinical origin during first epidemic; and (iii) group 3, sars-cov gd03t0 ... | 2005 | 16112670 |
| ct of the chest and abdomen in patients with newly diagnosed head and neck squamous cell carcinoma. | the benefits of ct scanning of the chest and abdomen as a routine screening method for patients with newly diagnosed head and neck squamous cell carcinoma (hnscc) remain unclear. | 2005 | 16114003 |
| effect of starch on the cariogenic potential of sucrose. | since in vitro and animal studies suggest that the combination of starch with sucrose may be more cariogenic than sucrose alone, the study assessed in situ the effects of this association applied in vitro on the acidogenicity, biochemical and microbiological composition of dental biofilm, as well as on enamel demineralization. during two phases of 14 d each, fifteen volunteers wore palatal appliances containing blocks of human deciduous enamel, which were extra-orally submitted to four groups of ... | 2005 | 16115331 |