Publications

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emergency. anthrax. 200112585066
in vino veritas. 200112593708
the anthrax threat: a concise guide for nps. 200112400346
fielding pleas for cipro. 200112400348
bioterrorism. 200112035346
bacterial skin infections in a tropical environment.the subject of bacterial skin infection in the tropics has shown some significant advances in the past few years, although it is still relatively understudied. of special interest is the emerging concern about the public health aspects of pyoderma, either primary or secondary to scabies, in developing countries. in addition, certain more unusual agents, such as bacillus anthracis and corynebacterium diphtheriae, continue to cause significant problems in some areas, while incidence of other tropi ...200111979120
cdc: be alert to symptoms associated with bioterrorism. 200112382635
anthrax and anthrax anxiety: sverdlovsk revisited. 200111962347
anthrax the facts. 200111974775
need to know basis. 200111974821
isolation, purification and partial chemical characterization of a lethal factor from common indian toad (bufo melanostictus, schneider) skin extract.indian toad (bufo melanostictus, schneider) skin extract (tse) is pharmacologically potent and probably contains several bioactive compounds [das et. al., indian j pharmacol, 28 (1996) 72]. a lethal factor was isolated and purified by neutral alumina column chromatography followed by hplc. spectroscopic (uv, ir, fab-mass) study indicated that the lethal factor (tse-lf) was a 254 da long chain compound with carbonyl, hydroxyl and ester as functional groups. ld50 of tse-lf was found to be 3.5 mg/k ...200112018580
[carbuncle (anthrax) as biological weapon].the authors explain the anthrax pathogeny as necessary base to treat the systemic anthrax, that it can be secondary to a terrorist aggression, that until now it causes death to damaged people. for fear that a contamination with anthracis spores by a terrorist aggression, it is imposed to administrate chymeprotection to damaged people, because once it is appeared the symptoms of the systemic illness, the antibiotics don't stop the process evolution. for that reason, we think it is important to kn ...200112056261
[anthrax]. 200111980392
terrorism response resources for clinicians. 200112080532
anthrax: factsheet. 200112105641
[anthrax as biological weapon]. 200111826774
[bioterrorism: a new problem of public health]. 200111816235
[the abcs on anthrax for health personnel].the purpose of this series of articles is to present to health personnel an updated summary on bioterrorism associated agents. in this first article an updated summary on anthrax is presented. emphasis has been placed on the characteristics of cases which occurred during october in the united states of america and on the experience of governmental agencies of that country to face the emergency. measures implemented in mexico are described as well. the authors are convinced that the best arm agai ...200111816237
the mayor, his troops, and the health of a city. 200111816774
anthrax. profile of a killer. 200111817276
war against anthrax. 200111844866
anthrax and other microbial threats. 200111852629
anthrax attack in the usa. 200111871791
[anthrax].anthrax is a serious bacterial infection sustained by bacillus anthracis and occurring in most mammals, especially grazing herbivors, but it can also involve humans when bacterial endospores enter the body through abrasions in the skin or by inhalation or ingestion. human disease results from contact with infected animals or contaminated animal products, while there are no known cases of human-to-human transmission. the most common form of human anthrax is the cutaneous infection, usually curabl ...200111822090
highlights from the annual scientific assembly: weapons of mass destruction: organized medicine's role in the national response to terrorism. 200111811866
responding to anthrax. 200111885187
bioterrorism preparedness and response in european public health institutes.the terrorist attacks on 11 september 2001 and the deliberate release of anthrax in the united states had consequences for public health not only there, but also in europe. europe's public health systems had to manage numerous postal materials possibly contaminated with anthrax. our survey aimed to document the response of european public health institutes to recent bioterrorist events to identify the gaps that need to be addressed; 18 institutes from 16 countries participated in this euroroundu ...200111891386
deliberate releases of biological agents: initial lessons for europe from events in the united states.the experience of autumn 2001, when anthrax spores were released in the postal system, had considerable consequences in the united states and in europe. the threat of covert deliberate releases against civilians has become a reality. in europe, despite the growing number of criminal hoaxes, no cases of anthrax linked to deliberate releases have been reported, and the only contaminated letters were addressed to american embassies abroad. nevertheless, the time has come for europe to set up effici ...200111891387
[bacillus anthracis: causative agent of anthrax].anthrax, an acute infectious disease of historical importance, is once again regaining interest with its use as a biological weapon. it is caused by b. anthracis, a gram positive spore forming rod usually surrounded by a capsule and producing toxin. it occurs most frequently as an epizootic or enzootic disease of herbivores that acquire spores form direct contact with contaminated soil. spores can survive for many years in soil. animal vaccination programs have reduced drastically the disease in ...200111892436
[anthrax]. 200111908180
[anthrax. the pathogen, the disease picture and possible use as a biological weapon]. 200111910856
the plain lawyer's guide to bioterrorism. 200111887760
the incompatibility between the plcr- and atxa-controlled regulons may have selected a nonsense mutation in bacillus anthracis.bacillus anthracis, bacillus thuringiensis and bacillus cereus are members of the bacillus cereus group. these bacteria express virulence in diverse ways in mammals and insects. the pathogenic properties of b. cereus and b. thuringiensis in mammals results largely from the secretion of non-specific toxins, including haemolysins, the production of which depends upon a pleiotropic activator plcr. in b. anthracis, plcr is inactive because of a nonsense mutation in the plcr gene. this suggests that ...200111886551
louis pasteur's beer of revenge.although by the mid-nineteenth century evidence existed for an association between micoorganisms and disease, it was the combined efforts of louis pasteur and robert koch that created the germ theory of disease--the theory that specific microbes cause specific diseases. surprisingly, the relationship between the two founders of microbiology and immunology was far from friendly.200111905832
[the return of anthrax: "the evil spirit is out of the bottle"]. 200111928599
bioterrorism: introduction and major agents. 200111930512
inhalational anthrax: threat, clinical presentation, and treatment.to provide nurse practitioners (nps) with a basic understanding of clinical presentation, transmission, diagnosis, pharmacological treatment, and post-exposure prophylaxis of inhalational anthrax.200111930529
anthrax meningitis: case report. 200111953221
just an accident waiting to happen. 200111966075
nhs staff given advice on treating anthrax patients. 200111966091
anthrax. when immunity may not be safe. 200111966151
the probability of severe disease in zoonotic and commensal infections.cross-species transfers of pathogens (zoonoses) cause some of the most virulent diseases, including anthrax, hantavirus and q fever. zoonotic infections occur when a pathogen moves from its reservoir host species into a secondary host species. similarly, commensal infections often have a primary reservoir location within their hosts' bodies from which they rarely cause disease symptoms, but commensals such as neisseria meningitidis cause severe disease when they cross into a different body compa ...200112123298
preparedness and response to bioterrorism.as we enter the 21st century the threats of biological warfare and bioterrorism (so called asymmetric threats) appear to be more real than ever before. historical evidence suggests that biological weapons have been used, with varying degrees of success, for many centuries. despite the international agreements to ban such weapons, namely the 1925 geneva protocol and the 1975 biological and toxin weapons convention, there is no effective international mechanism for challenging either the developme ...200111676515
anthrax blamed as two postal workers die in united states. 200111679374
bioterrorism. researchers question obsession with cipro. 200111679638
war on terror. anxious about anthrax. 200111682908
war on terror. a run on antibiotics. 200111682909
danger: handle with care. 200111682910
shadow of fear. 200111682911
anthrax. deadly delivery. 200111682912
a new state of fear. 200111682956
protecting yourself. 200111682958
bioterrorism: safeguarding the public's health. 200111684202
update: investigation of anthrax associated with intentional exposure and interim public health guidelines, october 2001.on october 4, 2001, cdc and state and local public health authorities reported a case of inhalational anthrax in florida. additional cases of anthrax subsequently have been reported from florida and new york city. this report updates the findings of these case investigations, which indicate that infections were caused by the intentional release of bacillus anthracis. this report also includes interim guidelines for postexposure prophylaxis for prevention of inhalational anthrax and other informa ...200111686472
recognition of illness associated with the intentional release of a biologic agent.on september 11, 2001, following the terrorist incidents in new york city and washington, d.c., cdc recommended heightened surveillance for any unusual disease occurrence or increased numbers of illnesses that might be associated with the terrorist attacks. subsequently, cases of anthrax in florida and new york city have demonstrated the risks associated with intentional release of biologic agents. this report provides guidance for health-care providers and public health personnel about recogniz ...200111686473
post-exposure anthrax prophylaxis. 200111689760
us expands anti-bioterrorist measures. 200111689831
a battle cry for biomedicine. 200111689860
bioterrorism threat becomes reality. 200111689863
crackdown on hazardous agents raises concern for bona fide labs. 200111689899
science marshalled to cut bioterror confusion. 200111689904
prophylactic treatment of anthrax with antibiotics. 200111691746
how anthrax gets a grip on cells. 200111691752
toll of anthrax cases reaches 15. 200111691753
bayer cuts price of ciprofloxacin after bush threatens to buy generics. 200111691754
anthrax, united states of america (update). 200111697083
homeland insecurity. 200111699131
a dose of reality for the health watchdogs. 200111699134
be a patriot. don't hoard cipro! 200111699135
perspectives. terrorism event no time to be learning on the job. 200111699157
tools of mass distraction. 200111699228
a no-show vaccine--for a mere $126 million. deal? 200111699229
confusion in spades. the anthrax scares reveal a public-health system in disarray. 200111699231
war on terror: biochem. tracking anthrax. 200111699428
war on terror. epidemic threats. 200111699429
attempts to stem anthrax fears stumble. 200111699540
update: investigation of bioterrorism-related anthrax and interim guidelines for exposure management and antimicrobial therapy, october 2001.since october 3, 2001, cdc and state and local public health authorities have been investigating cases of bioterrorism-related anthrax. this report updates previous findings, provides new information on case investigations in two additional areas, presents the susceptibility patterns of bacillus anthracis isolates, and provides interim recommendations for managing potential threats and exposures and for treating anthrax.200111699843
universities address mail security as anthrax fears rise. 200111700511
tackling anthrax. 200111700539
identification of the cellular receptor for anthrax toxin.the tripartite toxin secreted by bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a systemic infection. two components of the toxin enzymatically modify substrates within the cytosol of mammalian cells: oedema factor (of) is an adenylate cyclase that impairs host defences through a variety of mechanisms including inhibiting phagocytosis; lethal factor (lf) is a zinc-dependent protease that cleaves mitogen-activated prote ...200111700562
crystal structure of the anthrax lethal factor.lethal factor (lf) is a protein (relative molecular mass 90,000) that is critical in the pathogenesis of anthrax. it is a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (mapkk) family near to their amino termini, leading to the inhibition of one or more signalling pathways. here we describe the crystal structure of lf and its complex with the n terminus of mapkk-2. lf comprises four domains: domain i binds the membrane-translocating component of anth ...200111700563
counterterrorism. u.s. enlists researchers as fight widens against bioterrorism. 200111701894
anthrax. biodefense hampered by inadequate tests. 200111701907
chemistry. nota bene: know thine enemy. 200111701920
anthrax. 200111702421
experts doubts us is ready for biowarfare attack. 200111702725
cutaneous bacillus anthracis infection. 200111704683
images in clinical medicine. cutaneous anthrax infection. 200111704684
index case of fatal inhalational anthrax due to bioterrorism in the united states. 200111704685
recognition and management of anthrax--an update. 200111704686
risk of deliberately induced anthrax outbreak. 200111705480
letter in pakistan tests positive for anthrax spores. 200111705501
us anthrax scares prompt action on bioterrorism. 200111705502
anthrax in usa--attacks "deadly but treatable". 200111705575
pediatric implications in bioterrorism part ii: postexposure diagnosis and treatment.bioterrorism is an old tactic used in warfare. the use of fatal diseases or man-made poisons to subdue others has not been limited to wartime. trauma personnel should be aware of commonly used agents, the signs and symptoms of their exposure, and recommended treatment. children can be victims of terrorists' acts and need special attention because of their unique response to exposure, varying dosages of medications, and lack of active immunity.200111707769
update: investigation of bioterrorism-related anthrax and interim guidelines for clinical evaluation of persons with possible anthrax.since october 3, 2001, cdc and state and local public health authorities have been investigating cases of bioterrorism-related anthrax. this report updates findings as of october 31, and includes interim guidelines for the clinical evaluation of persons with possible anthrax. a total of 21 cases (16 confirmed and five suspected) of bioterrorism-related anthrax have been reported among persons who worked in the district of columbia, florida, new jersey, and new york city (figure 1). until the sou ...200111708591
updated recommendations for antimicrobial prophylaxis among asymptomatic pregnant women after exposure to bacillus anthracis.the antimicrobial of choice for initial prophylactic therapy among asymptomatic pregnant women exposed to bacillus anthracis is ciprofloxacin, 500 mg twice a day for 60 days. in instances in which the specific b. anthracis strain has been shown to be penicillin-sensitive, prophylactic therapy with amoxicillin, 500 mg three times a day for 60 days, may be considered. isolates of b. anthracis implicated in the current bioterrorist attacks are susceptible to penicillin in laboratory tests, but may ...200111708594
interim recommendations for protecting workers from exposure to bacillus anthracis in work sites in which mail is handled or processed.cdc has developed interim recommendations to assist personnel responsible for occupational health and safety in developing a comprehensive program to reduce potential cutaneous or inhalational exposures to bacillus anthracis spores among workers in work sites in which mail is handled or processed. such work sites include post offices, mail distribution/handling centers, bulk mail centers, air mail facilities, priority mail processing centers, public and private mail rooms, and other settings in ...200111708595
the hunt for the anthrax killers. 200111710155
protecting america. the top 10 priorities. 200111710159
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