Publications

survival in vibrio cholerae in the live shellfish.		1975	1239409
[electron microscopic studies of epinephrine choroiditis in rabbits. 3. scanning electron microscopic observations of the retinal pigment epithelial cells in the early stage (author's transl)].		1975	1239915
[genetic characteristics of r factor of vibrio cholerae and adaptive development of resistance].		1975	1240174
[electron microscopic observation of cholera toxin molecules].		1975	1240197
[biological activity of the cell components of vibrio cholerae. ii. a comparison between if30 and i-lps fractions].		1975	1240223
[quantitative analysis of cholera toxin - use of cultured tumor cells and their mutants].		1975	1240259
[reverse transformation of tumor cells caused by cholera toxin and the substance inhibiting the process].		1975	1240260
[classification of vibrio cholerae and related organisms].		1975	1240295
[antibacterial immunity in experimental cholera].		1975	1240315
complete and defective bacteriophages of classical vibrio cholerae: relationship to the kappa type bacteriophage.	the classical vibrio cholerae strain nih 41 contains two temperate bacteriophages, designated vca-1 and vca-2, that are distinguished by immunity, plaque morphology, induction kinetics, and particle morphology. both phage are serologically related to phage kappa. however, only phage vca-2 has the kappa type host range and immunity. the induction kinetics and immunity patterns of classical vibrios suggest that these strains may contain defective phage related to the phages isolated from nih 41. c ...	1975	16789156
isolation, characterization and public health aspects of vibrio cholerae nag isolated from a danish duck farm.	the hygienic and pathogenic consequences of the isolation of vibrio cholerae nag from the conjunctiva of two ducklings, from brackish water samples in their surroundings, and from the intestinal contents of a duckling, are discussed in relation to present knowledge of the occurrence of vibrio cholerae nag in man and animals.	1975	18777317
[nursing of children with cleft lip and cleft palate].		1975	246079
gastrointestinal complications after external megavoltage treatment.	66 cases treated with external megavoltage irradiation for various malignant diseases in the abdomen are presented 26 patients (39%) had radiation reactions during and immediately after the treatment. late complications at least two months after the treatment appeared in 15 patients (23%). the relatively low frequency of intestinal disturbances induced by radiotherapy in the present series may have been caused by the low weekly dose in the abdomen and the practise of a split-course interval in t ...	1975	415383
catalytic oxidation of 2,4,5-trihydroxyphenylalanine by tyrosinase: identification and evolution of intermediates.	the oxidation of 3,4-dihydroxyphenylalanine (dopa) by o2 catalyzed by tyrosinase yields 4-(2-carboxy-2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaquinone-h+). this evolves non-enzymatically through two branches (cyclization and/or hydroxylation), whose respective operations are determined by ph. the hydroxylation branch of o-dopaquinone-h+ only operates significantly at ph < or = 5.0 and involves the accumulation of 2,4,5-trihydroxyphenylalanine (topa), which has been d ...	1975	1445949
identification of the ubiquinone-binding site of nadh:ubiquinone oxidoreductase (complex i) from neurospora crassa.	in order to localize the ubiquinone-binding site of complex i (nadh:ubiquinone oxidoreductase), a novel photoreactive ubiquinone analogue (q0c7arn3) has been synthesized. it is shown that the direct chemical precursor of this analogue (q0c7arno2) and the analogue itself are accepted as substrates in an enzyme assay utilizing ubiquinone-depleted mitochondrial membranes of neurospora crassa. the activity of the enzyme applying these derivatives is inhibited by 50% at a concentration of 9 and 20 mi ...	1975	1445878
final inline filtration: a means of decreasing the incidence of infusion phlebitis.	infusion phlebitis is the most common complication of intravenous therapy. six methods of reducing the incidence of infusion phlebitis including inline final filtration, buffers, heparin, hydrocortisone, heparin-hydrocortisone combinations, and frequent set changes were tested in a two part randomized prospective double-blind study of 266 surgical patients. patients who received filtered fluids had a significantly decreased incidence of infusion phlebitis as compared with that of controls (p = 0 ...	1975	432800
nutritional implications of the maillard reaction.		1975	415265
multi-well cell monolayers for immunocytochemistry. an alternative to cytocentrifuge preparations.		1975	1538147
anti-ganglioside antibodies in peripheral neuropathy.	there have recently been reports that patients with motor neuropathy with multifocal conduction block have high circulating levels of antibodies to the ganglioside gm1. other reports have described the presence of these antibodies in patients with inflammatory demyelinating neuropathy and patients with lower motor neurone forms of motor neurone disease. we have established an elisa assay for igg and igm antibodies to asialo-gm1 (sigma). we used this assay to measure such antibodies in serum from ...	1975	1343861
incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration.	a review of 498 patients treated with high-dose methotrexate (mtx) with citrovorum factor rescue revealed 29 drug-related deaths. until the important factors in those deaths are identified, the use of high-dose mtx should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.	1975	301783
cytogenetic follow-up after allogeneic bone marrow transplantation for ph+ cml: update of the european cooperative study.		1976	1878695
mass spectrometry of some ultraviolet absorbing derivatives of sugars and related alditols: identification in biologic fluids after separation by high performance liquid chromatography.	the 70 ev electron impact mass spectra of the acyclic perbenzoyl 0-benzyloximes of several mono- and disaccharides of clinical interest and the perbenzoates of certain related alditols have been obtained and compared with those of other similar derivatives studied previously. in general, the spectra of the benzyloximes contain molecular ions and characteristic fragments due to [c6h5]+,[c7h7]+,[c6h5co]+ and [c6h5cooh]+., losses of hcho, c6h5coo. and c6h5cooh, and cleavages along the carbon chain. ...	1976	420916
7 steps to selling your practice.		1976	274413
clinical neuropathological conference.		1976	170050
[wound suppuration after 1st surgical debridement].		1976	333159
emergency problems involving sinusitis.	the problems which the primary physician or flight surgeon might expect to encounter with regard to acute sinusitis are presented. the need for exact diagnosis, the goals of treatment, and the management of the progress of the disease processes are reviewed.	1976	420671
congenital nystagmus surgery. a quantitative evaluation of the effects.	nystagmus intensities at various gaze angles were studied both preoperatively and postoperatively, using accurate ocular motility recordings, in three cases of congenital nystagmus. in addition to shifting the nystagmus null, the surgery broadened the null region and resulted in an overall reduction in nystagmus intensity at all gaze angles. surgical rotation also resulted in improved visual acuity in all cases. the postoperative acuity at 0 degrees was better than the preoperative acuity at bot ...	1976	420633
the response of serum growth hormone and prolactin to training in weight-maintaining healthy males.	resting levels of serum growth hormone (gh) and prolactin (prl) were measured pretraining, 3 weeks and 10 weeks posttraining in seven college age males. the exercise consisted of thrice weekly sessions at 70% vo2max for 20 minutes plus warmup and cool down. body weight remained constant during the ten week training period. however, body fat decreased significantly. resting daytime levels of gh decreased significantly with training while resting prl levels were unchanged. the hormone responses su ...	1976	2366534
[a clamp for securing bottles containing blood and blood substitutes].		1976	2366445
[ambulatory care and intensification of the rehabilitation of patients following reconstructive surgery on the major vessels].		1976	2366433
[the organization and extent of medical aid to burned patients in nonspecialized hospitals].		1976	2366432
oculosympathetic paresis. analysis of 100 hospitalized patients.	of 100 consecutive, adult, hospitalized inpatients with acquired unilateral oculosympathetic palsy, in 63 the central neuron was involved-usually due to strokes; in 21, tumor or trauma affected the preganglionic neuron; and in 13, postganglionic damage was sustained from a variety of causes. the preponderance of first neuron involvement by stroke is in part a reflection of patient sampling, but emphasizes the fact that central causes of horner's syndrome are common.	1976	420595
distribution of cholera organisms in experimental vibrio cholerae infections: proposed mechanisms of pathogenesis and antibacterial immunity.	this study was undertaken to determine the sequence of events in the microenvironment of the intestinal tract that culminate in the symptoms of cholera and to attempt to define more clearly the mechanisms involved in antibacterial immunity. the extent to which mucus occurs in the normal intestine of rabbits and the appearance of the intestinal villi in unfixed frozen sections was demonstrated. the villi and intervillous spaces were found to be normally covered by a layer of mucoid material that ...	1976	1248870
familial clustering of selective iga deficiency.	serum iga levels of 35 healthy iga-deficient index cases, of their 180 first-degree relatives, and of 31 other family members were studied. iga deficiency was detected in 7.2% of the first-degree relatives, which is significantly more than the 0.25% frequency of iga deficiency in healthy finnish blood donors. subnormal serum iga levels were found in additional 13 (7.2%) first-degree relatives. the familial clustering of iga deficiency seemed to be controlled by multigenic factors. iga-deficient ...	1976	1251582
chemical characterization of the structure of cholera toxin and its natural toxoid.	acrylamide gel electrophoresis demonstrated that the toxin of vibrio cholerae is comprised of three polypeptide chains, alpha, beta, and gamma, of molecular weights 24,000, 9,700, and 9,700 daltons, respectively. amino acid sequence analysis of intact toxin indicated a molecular composition of alpha gamma beta4. acrylamide gel electrophoresis and sequence analysis confirmed that the natural toxoid (choleragenoid) is identical to the toxin beta-chain. the alpha- and gamma-chains of the toxin are ...	1976	1254995
aspects of the interaction of vibrio cholerae toxin with the pigeon red cell membrane.	the ganglioside galactosy-n-acetylgalactosaminyl [sialosyl] lactosyl ceramide (gm1) is readily accumulated in pigeon red cell membranes soaked with [3h]gm1 (1-100 mug/ml) at 37 c for 30 min. this treatment enhances the activation of adenyl cyclase by the toxin of vibrio cholerae. an attempt was made at correlation of the amount of incorporated gm1 with the increased binding of toxin and activation of adenyl cyclase. cells with less than 2 mug of incorporated gm1 per 4 x 10(9) cells bind 5-10 mug ...	1976	1254996
stimulation of adenylate cyclase by vibrio cholerae toxin and its active subunit.	the mechanism by which vibrio cholerae toxin and its active subunit a stimulate adenylate cyclase of rat liver plasma membrane after in vivo or in vitro exposure was investigated. stimulation of adenylate cyclase was more efficient with cholera toxin than with subunit a in whole animals and in "soluble" preparations of adenylate cyclase. toxin-stimulated plasma membrane adenylate cyclase activity persisted after solubilization from the membrane by detergent, while subunit a stimulation was destr ...	1976	1254997
antitumor immunity. ii. viability, tumorigenicity, and immunogenicity of neuraminidase-treated tumor cells: effective immunization of animals with a tumor vaccine.	a dimethylbenzdithionaphthene (dbdn)-induced fibrosarcoma showed reduced transplantability if previously treated with vibrio cholerae neuraminidase (vcn). however, the reduced transplantability of vcn-treated tumor cells was not associated with any loss of their viability or tumorigenic capability, but appeared to be due to their increase in immunogenicity. high doses of vcn-treated tumor cells could grow even in normal individuals. lower doses, which did not induce tumor development in normal i ...	1976	1255753
selective modification of cell surface proteins and thymidine transport in hamster cells exposed to cholera toxin.	the increased adherence and morphological response which occurs in chinese hamster ovary cells as a result of exposure to cholera toxin is paralleled by modification in the relative exposure of outer proteins. mild proteolysis treatment of the cells prelabeled with [3h] glucosamine reveals a markedly different kinetics of release of external glycopeptides as a result of exposure to cholera toxin. selective alterations in external tyrosyl-rich proteins can also be detected by lactoperoxidase-cata ...	1976	1256059
[exocrine pancreatic function, intestinal resorption and reaction to vibrio cholerae infection in protein deficiency].	six patas monkeys were fed a protein-free diet while 16 animals of the same species receoved a standard monkey diet. the protein-depleted monkeys showed reduced absorption of folic acid but not dxylose, and 5 out of 6 exhibited depressed exocrine pancreatic function. when challenged with vibrio cholerae, animals with reduced folic acid absorption and pancreatic enzyme production excreted the micro-organisms for a longer time.	1976	1257727
interactions of cadmium and selenium in rat plasma in vivo and in vitro.	75se and 109cd tracers were used to study the binding of se and cd to plasma proteins at various seo32- doses and times upt to 24 h after the simultaneous subcutaneous administration of seo32- markedly increased both se and cd plasma levels over that in control animals. gel permeation chromatography of plasma indicated that at all times up to 24 h cd and se were bound in an atomic ratio of approx. 1 : 1 in 330 000 and 130 000 dalton fractions. from 4 to 24 h, cd and se appeared in the 420 000 da ...	1976	1260013
virulence factors involved in the intraperitoneal infection of adult mice with vibrio cholerae.	nonmotile mutants of vibrio cholerae isolated from ogawa, inaba, and el tor strains were less virulent than parent wild types when administered to adult mice intraperitoneally. the cells were suspended in 5% hog gastric mucin. antitoxic immunity did not protect mice against this type of challenge, but a ribosomally derived vaccine did. intraperitoneal injection of 10 50% lethal doses of enterotoxin (based on intravenous doses) was without toxic manifestations as were 10(10) heat-killed vibrios s ...	1976	1262061
the detection of antibodies in human and animal filariases by counterimmunoelectrophoresis with dirofilaria immitis antigens.	counterimmunoelectrophoresis revealed the presence of precipitin antibody in all of 6 dogs and the 1 cat infected with dirofilaria immitis and in the serum of 17 of 24 individuals living in a setting of hyperendemic subperiodic bancroftian filariasis. antigens used in the test were prepared from microfilariae and adult male d. immitis. some humans and animals had antibodies to both antigens while others had antibodies against microfilariae or adult worms only. the presence of soluble circulating ...	1976	1262695
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.	four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...	1976	1262709
correspondence: growth plate defects in foals.		1976	1265980
biochemical studies on the cell wall lipopolysaccharides (o-antigens) of vibrio cholerae 569 b (inaba) and el-tor (inaba).	lipopolysaccharides were isolated from the cell walls of vibrio cholerae 569 b (inaba) and el-tor (inaba). chemical analysis revealed the presence of glucose, fructose, mannose, heptose, rhamnose, ethanolamine, fatty acids and glucosamine. the lipopolysaccharides do not contain 2-keto-3-deoxyoctonate, the typical linking sugar of polysaccharide and lipid moieties of enterobacterial lipopolysaccharides. galactose, a typical core polysaccharide component of many gram-negative bacteria was also abs ...	1976	1268236
synergistic protective effect in rabbits of immunization with vibrio cholerae lipopolysaccharide and toxin/toxoid.	subcutaneous immunization of rabbits with a combination of vibrio cholerae lipopolysaccharide (lps) and enterotoxin induced a more than 100-fold-higher degree of protection against intestinal challenge with live cholera vibrios than did vaccination with either of the two antigens alone. such a synergistic effect was also obtained by immunization with a combination of lps and choleragenoid. the immunization with lps and toxin (or toxoid) in combination did not enhance the reistance to toxin chall ...	1976	1270131
morphological and steroidogenic changes in cultured adrenal tumor cells induced by a subunit of cholera enterotoxin.	a purified subunit of the cholera enterotoxin molecule was found to have morphological and steroidogenic inducing effects similar to those induced by the native enterotoxin on monolayer tissue cultures of y1 adrenal tumor cells, although 1,000 times more subunit than toxin (weight basis) was required for maximal effects. in contrast to the whole toxin, the effects of the active subunit could not be prevented by prior incubation with either gm1 ganglioside or with antibodies directed against chol ...	1976	1270152
colony morphology of vibrio cholerae on sv medium.		1976	1270369
effect of hgcl2 on rat kidney cells in primary culture.	single cell suspensions, obtained from rat kidneys, were cultured with various concentrations of hgcl2 for different times to examine the effects on cellular synthetic activity. unexpectedly, the rna synthesis of kidney cells was stimulated with low doses of hgcl2, whereas it was inhibited with higher doses. even at a higher dose, rna synthesis was stimulated during early incubation but was inhibited during longer incubations. thus, the effect of mercury showed a biphasic pattern both in dose-re ...	1976	1271750
effect of hgcl2 on rat kidney cells in primary culture.	single cell suspensions, obtained from rat kidneys, were cultured with various concentrations of hgcl2 for different times to examine the effects on cellular synthetic activity. unexpectedly, the rna synthesis of kidney cells was stimulated with low doses of hgcl2, whereas it was inhibited with higher doses. even at a higher dose, rna synthesis was stimulated during early incubation but was inhibited during longer incubations. thus, the effect of mercury showed a biphasic pattern both in dose-re ...	1976	1271750
modified tumor cells in the immunotherapy of solid mammary tumors.		1976	1271892
teratogenic potential of noise in mice and rats.		1976	1273844
acetylcholine release from the nerve terminals of the guinea-pig ileum by naja venoms.		1976	1273858
[test of degranulation of basophils and mast cells for detection of allergic diseases (literature survey)].		1976	1274295
sequence similarity between cholera toxin and glycoprotein hormones: implications for structure activity relationship and mechanism of action.		1976	1275921
proceedings: increase in prostaglandin e2 and f2alpha in inflammatory exudate at 4-48 h after uvb irradiation of human skin.		1976	1276048
[reduction of the biological activity of vibrio cholerae culture filtrates exposed to neuraminidase inhibitors].	experiments were conducted on a model of edema of albino mouse paws; a study was made of the effect of neuraminidase inhibitors on the cholerogenic effect of a filtrate of cholera vibrio culture. it appeared that addition to the filtrate of inhibitors depressed its biological activity. since no cholerogenic action was possessed by the purified neuraminidase preparations from the cholera vibrios it was suggested that there existed a chemical affinity between the region of cholerogen responsible f ...	1976	1276448
glial cells and extracellular potassium: their relationship in mammalian cortex.	simultaneous recordings were made of glial cell potentials and the extracellular potassium concentration ([k+]o) in cat cortex in an attempt to provide more quantitative information about the sensitivity of mammalian neuroglia to changes in [k+]o. a penicillin epileptogenic focus served to generate both transient and sustained elevations in [k+]o, thus allowing measurement of glial membrane potential (vm) at both resting and increased [k+]o levels many times during the same experiment. resting v ...	1976	1276917
differences between leech and mammalian nervous systems in metabolic reaction to k+ as an indication of differences in potassium homeostasis mechanisms.		1976	1276949
absolute configuration of 3-hydroxy fatty acids present in lipopolysaccharides from various bacterial groups.	the absolute configuration of 3-hydroxy fatty acids has been studied, which are present in the lipopolysaccharides of the following bacteria: phodopseudomonas gelatinosa, rh. viridis, rhodospirillum tenue, chromobacterium violaceum, pseudomonas aeruginosa, bordetella pertussis, vibrio metchnikovii, vibrio cholerae, salmonella spp., escherichia coli, shigella flexneri, proteus mirabilis, yersinia enterocolitica and fusobacterium nucleatum. the 3-hydroxy acids were liberated by strong alkaline hyd ...	1976	1278168
decline of passively acquired antibodies in young and adult rats.	the rate of decline (half-life) of passively acquired antibodies was studied in young and adult rats. there was a wide variation in half-life when varying concentrations of diphtheria or tetanus antibody were administered by intraperitoneal injection; half-lives ranged from 1-2 to 12-0 days in both age groups. when different concentrations of diphtheria and tetanus antibody were administered together by the same route, significant differences in half-lives were demonstrated in individuals of eac ...	1976	1278935
photobiological activity of furazolidone.		1976	1086295
a streptomycin-sensitive revertant of a streptomycin-dependent strain of vibrio cholerae.	a study was made of a streptomycin-sensitive revertant of a streptomycin-dependent strain of v. cholerae. the revertant, designated as strain kb599, appears to be avirulent in animal experimental models. however, no evidence of multiplication was found in infant mice.	1976	1086742
intestinal immunization with soluble bacterial antigens: the example of cholera toxoid.	the studies described are aimed at a better understanding of the intestinal immunological system and its role in protection against enteric infection. the cellular kinetics of the intestinal immune response to cholera toxoid were studied in rats and the protection afforded by toxoid immunization was studied in dogs. memory was demonstrated in the gut immune system. plasma cells containing iga antitoxin appeared in large numbers in gut lamina propria when intraduodenal boosting followed either in ...	1976	1086763
membrane expression of thy-1,2 and gm1 ganglioside on differentiating t lymphocytes.	c3h mouse bone marrow cells were separated by discontinuous bsa gradient centrifugation. marrow cells from the 17 to 19%, 19 to 21% to 23%, 23 to 25%, 25 to 27% interfaces and the cell pellet were treated with thymic factor (tf) or with vibrio cholerae neuraminidase (vcn), followed by anti-thy-1,2 and anti-gm1 ganglioside antisera. antigens determined by anti-thy-1.2 or anti-gm1 were expressed either with tf or vcn within a 30-min incubation. cells expressing these antigens after vcn or tf treat ...	1976	1086862
surface molecules of cultured human lymphoid cells.	cell surface molecules of cultured human lymphoid cells were selectively labeled by lactoperoxidase-catalyzed iodination and examined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. two major iodinated species with apparent mol. wts. of 27 000 and 35 000 daltons were detected on autoradiographs of the labeled proteins of human lymphoid cell lines believed to be of thymus-independent (b) cell origin. neither molecule was detected on putative thymus-dependent (t) l ...	1976	1087235
nucleosides. 1. 9-(3'-alkyl-3'-deoxy-beta-d-ribofuranosyl)adenines as lipophilic analogues of cordycepin. synthesis and preliminary biological studies.	a series of lipophilic 9-(3'-alkyl-3'-deoxy-beta-d-ribofuranosyl)adenines of increasing chain length was synthesized from the corresponding branched sugars via titanium chloride catalyzed ribosylation of chloromercuri-6-benzamidopurine. enhanced growth inhibitory activity was observed against (ccrf-cem human lymphoblastic leukemia cells in culture as the length of the alkyl side chain in the sugar and the resultant lipophilic character of the nucleoside were increased. experiments involving inco ...	1976	1087343
persistence of anti-immunoglobulin on the lymphocyte surface.		1976	1087371
ampicillin-resistant strains of haemophilus influenzae type b in north carolina.		1976	1087376
[long-term cardiac arrest by cardioplegic coronary perfusion (author's transl)].	the mg++ aspartate-procaine-cardioplegia has been proven in animal experiments as well as from 1970 til 1975 in more than 1000 open-heart-procedures by a myocardial temperature of 32 degrees c and aortic crossclamping time up to 40 minutes superior to all other known procedures of cardiac preservations. to guarantee a safe myocardial protection of the arrested heart for a remarkable longer period of total ischemia, we further developed the cardioplegic technique in the animal lab, and use it now ...	1976	1087482
sensitivity of trichomonas vaginalis to metronidazole, tinidazole, and nifuratel in vitro.	prompted by the sensitivity of trichomonads to metronidazole and nifuratel in clinical practice, a study was conducted in 1971-1972 of 63 consecutive strains of trichomonas vaginalis isolated from women with clinically refractory vaginal discharge. their susceptibility to metronidazole, tinidazole, and nifuratel was tested, using a serial tube dilution technique. the minimum concentrations which in 48 hrs caused immobilization and lysis of trichomonads cultured in diamond's medium was assessed. ...	1976	1087577
yersinia enterocolitica : a review of its role in food hygiene.	since yersinia enterocolitica, now classified as a member of the enterobacteriaceae, was recognized as a distinct species in 1964 it has been isolated with increasing frequency from man and animals (including dogs and pigs) and from some human foods. y. enterocolitica infections are now seen as a cause for some concern in both human and veterinary medicine. the organism is commonly found in specimens from swine slaughterhouses and has been isolated from samples of market meat, vacuum-packed beef ...	1976	1087589
immunological studies on metastrongylus apri infection. iv. influence of whole body x-irradiation or anti-guinea pig thymocyte serum injection on acquired immunity in thymectomized guinea pigs.		1976	1087673
treatment of pneumocystis carinii pneumonia in infancy.	pentamidine is recommended for the therapy of pneumocystis carinii pneumonia either alone or, in severe cases, combined with pyrimethamine. attention is drawn to the importance of supporting symptomatic treatment, particularly with the promethazine-hydergine cocktail, and to the possibilities for general and drug prophylaxis.	1976	1087956
effect of sulfadoxine on transmission of vibrio cholerae infection among family contacts of cholera patients in calcutta.	sulfadoxine, a long-acting sulfonamide, and tetracycline were compared as regards their effectiveness in reducing transmission of cholera infection among the contacts of cholera patients in calcutta. a total of 109 healthy family contacts of confirmed hospitalized cholera patients were treated with a single oral dose of sulfadoxine graded according to age. another similar group of 101 contacts received 6 divided doses of oral tetracycline over a period of 3 days. all these contacts were bacterio ...	1976	1088098
global surveillance of antibiotic sensitivity of vibrio cholerae.	strains of vibrio cholerae-1156 from various parts of the world-were examined by standardized antibiotic sensitivity tests in one centre, to determine the global incidence of antibiotic resistance in this organism and to assess the extent to which differences in methods of sensitivity testing might be responsible for discrepancies in the reported incidence of resistant strains. of the strains examined, 1127 were fully sensitive to ampicillin, chloramphenicol, tetracycline, furazolidone, and thre ...	1976	1088100
value of phage typing of vibrio cholerae biotype eltor in west africa.	the epidemiological value of phage typing of el tor vibrios in west africa was assessed by testing 211 representative strains from all outbreaks of the cholera epidemic in togo (1970-73) with the prophage typing method of nicolle et al. and the lytic el tor phages of basu & mukerjee. prophage typing proved to be of limited epidemiological value in togo since 203 of the 211 strains tested belonged to the same phage type-namely, type 2 of nicolle et al., which corresponds to the celebes type of ta ...	1976	1088101
[study of the heterogenetic antigens in vaccinal preparations of v. cholerae].	there proved to be a serological similarity between the antigens of the human small intestine, the stomach and the liver, and the antigens of various cholera vibrio fractions. no antigenic similarity was revealed in examination of the heart and kidney. heterogenous antigen was found not only in the somatic v. cholerae antigen, strain 569 (b), but also in the cholerogen-toxoid obtained from it. at present it is the most widespread prophylactic preparation.	1976	1088347
ampicillin-resistant hemophilus sp.		1976	1082793
[influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats].	in tests with determination of pain reaction in rats registered by their squeak and arising in reponse to a single electric irritation of the tail evidence was obtained to the effect that substances both lowering the serotonin content in the brain (p-chlorphenylalanine, reserpine) and raising it (5-oxytryptophan, pargilin) cause a fall of the threshold, viz. 5-oxytryptophan and pargilin display antagonism to the analgetic effect of trimeperidine hydrochloride, whereas p-chlorphenylalanine, and i ...	1976	1082823
epithelial regeneration of transposed intestine after high doses of x-irradiation.	the regeneration capacities of normal and transposed small bowel epithelium were compared in rats after applying high doses of x-irradiation. it has been shown that the potency of the mucosa to regenerate is much higher than assumed and that the mucosa can regenerate after single doses varying from 2000-5000 r. even in the villus epithelium and in flat epithelium covering infiltrates of the lamina propria cells survive, which are still able to resume proliferative activity several days after irr ...	1976	1083838
adhesion of cholera phage to glass surfaces at high inactivation temperatures.	decimal dilutions of cholera phage heated in test tubes at the temperature range of 65 degrees to 70 degrees showed an erratic behaviour in that the residual counts had no relationship to the quantity of phage originally present in the tubes. if the contents of the heated tubes were decanted off and the empty tubes washed repeatedly with broth, the recovery of phage from successive washings of the tubes was much higher than what would be expected on the basis of the simple dilution effect of was ...	1976	798584
comparative study of reactions and serological response to cholera vaccines in a controlled field trial conducted in the ussr.	this article presents the results of a comparative study of the reactogenicity and the serological response induced by a number of cholera vaccines. conducted in the ussr on 998 adults aged 18 years and over, the study covered whole-cell heat-killed and formalin-inactivated cholera vaccines, whole-cell heat-killed el tor vaccine, and a new partially purified toxoid preparation proposed for the immunoprophylaxis of cholera-all administered by hypodermic syringe or jet injector. the most marked re ...	1976	798636
vibrio parahaemolyticus: aetiological agent of food poisoning.	after mentioning the principal morphological, cultural, physiological, biochemical, enzyme and serological characteristics of vibrio parahaemolyticus (a facultative halophilic bacterium and the aetiological agent of food poisoning caused by the consumption of fish products) a description is given of its ecological aspects, geographical distribution, and potential enteropathogenicity for man, with general information on its isolation and identification.	1976	798718
[manifestation of intestinal immunity to vibrio cholerae].		1976	799289
[microagglutination reaction with labeled cholera vibrios].		1976	799370
[cell envelopes and lipopolysaccharides of gram-negative bacteria (author's transl)].		1976	800276
[future perspective in the use of disinfectants].	the effects of different combinations of quaternary ammonium compounds (sanitized, sanigard) on faecal and soil organisms demonstrate the usefulness of these products (dilution 1/100,000). a contact time of 30 seconds to 4 minutes is sufficient for bacteriocidal activity. materials treated with these compounds retain their bacteriocidal activity after 10 washes with boiling water and for over a month with normal usage. the disinfection of a door handle contaminated with vibrio cholerae or salmon ...	1976	801260
immunological studies in murine osteosarcoma. immunogenicity, growth kinetics, and immunotherapy.	a transplantable murine osteosarcoma is described. following transplantation into a syngeneic mouse the tumor grows rapidly and kills the mouse with pulmonary metastases simulating human osteosarcoma. a cell-mediated antibody response is evoked in the host mouse as demonstrated by in vivo and in vitro tests. the number of pulmonary metastases may be decreased with adjunctive immunotherapy following excision of the primary tumor. immunotherapeutic materials include bcg and isologous cells treated ...	1976	1063129
immunotherapy of human leukemia with neuraminidase-modified cells.		1976	1063908
comparative study of alkaline phosphatase activity in lymphocytes, mitogen-induced blasts, lymphoblastoid cell lines, acute myeloid leukemia, and chronic lymphatic leukemia cells.	alkaline phosphatase [orthophosphoricmonoester phosphohydrolase (alkaline ph optimum), ec 3.1.3.1] purified from a burkitt lymphoma cell line (daudi) and moloney-virus-induced murine leukemia (yac) showed unique catalytic properties in substrate specificity and inhibition by cysteamine-s-phosphate. it migrated on polyacrylamide gel electrophoresis in a single activity band. alkaline phosphatase with similar properties was found in several human lymphoblastoid cell lines, in chronic lymphatic leu ...	1976	1064015
elucidation of hydrocarbon structure in an enzyme-catalyzed benzo[a]pyrene-poly (g) covalent complex.	the carcinogen, benzo[a]pyrene, was covalently attached to poly (g) by liver microsomes from rats pretreated with 3-methylcholanthrene. the complex was hydrolyzed with enzymes or base and products were isolated by sephadex chromatography. absorbance and fluorescence spectra of the products fit that of red-shifted pyrene aromatic system and suggest that metabolism has occurred at the 7-, 8-, 9-, and 10-positions of the hydrocarbon. benzanthracene or chrysene fluorescence were not observed in thes ...	1976	1064016
immune markers in adult acute leukemia.	three cases of adult acute leukemia were examined for immunologic markers. incubation of leukemic cells with anti-d (igg)-coated erythrocytes was used for the identification of monocytes; sheep erythrocytes were employed for t-cells and fluorescein-conjugated anti-mixed immunoglobulins for b-cells. it was shown that igg receptors (monocytes) were present on immature cells with predominant monocytic components; t- and b-cell markers were absent in the mono- and myelocytic leukemias.	1976	1065217
inhibition of calcium phosphate precipitation by human salivary secretions.		1976	1065265
[induction of phagocytosis by immunotherapy against leukemic leukocytoblasts].	since 1975, the authors have been working in immunochemotherapy in acute myeloblastic leukemic adult patients. autologous leukemic leucocytoblasts have been cultured with vibrio cholerae neuraminidase (nvc). thereafter, neoplastic cells were radiated with cobalt bomb and frozen to--70degreesc and afterwards 5 x 10(6) of these leucoblasts were intradermally injected to each patients every eight days. all patients received between six to ten injections. so far, ten such patients have been followed ...	1976	1066088
immune responses in cholera vaccinated persons.		1976	1066435
choleragen-mediated release of trapped glucose from liposomes containing ganglioside gm1.	125i-labeled choleragen was bound to liposomes containing galactosyl-n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (gm1), but not in large amounts to ganglioside-free liposomes nor to those containing n-acetylneuraminylgalactosylglucosylceramide (gm3), n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (gm2), or n-acetylneuraminylgalactosyl-n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (gd1a). choleragen released trapped gluco ...	1976	1068459
therapeutic effectiveness of neuraminidase-treated tumor cells as an immunogen in man and experimental animals with leukemia.	the immunogenicity of leukemia l1210 in dba/2 ha and 6c3hed lymphosarcoma tumor cells in c3h/f mice was significantly increased after treatment with v. cholerae neuraminidase. dba/2 ha and c3h/f mice repeatedly immunized with neuraminidase-treated tumor cells rejected subsequent challenge of 10(7) or 10(6) untreated tumor cells, respectively. based on the 51cr microcytotoxicity assay, both strains of mice showed strong complement-dependent antibody titers and cell-mediated immunity. sera and spl ...	1976	1069551
adjuvant immuno- and/or chemotherapy with neuraminidase-treated autogenous tumor vaccine and bacillus calmette-guérin for head and neck cancers.		1976	1069553