Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| effects of helicobacter pylori on histamine and carbachol stimulated acid secretion by human parietal cells. | helicobacter pylori (h pylori) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. pathophysiological pathways by which h pylori interacts with acid secretion are still unclear. the effects of h pylori on (14c) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. isolated oxyntic glands were stimulated with submaximal concentrations of histamine or carbachol and incubated with sonicates of different h pylori ... | 1994 | 8020799 |
| [current topics in infectious diseases]. | in this symposium, we discussed the current aspects of the infectious diseases which have been becoming important problems in japan. the following diseases were taken up the matter of mrsa infection, helicobacter pylori infection, hiv-1 infection and hcv infection. 1) mrsa infection: epidemiology of hospital acquired infection by mrsa and its management of prevention. 2) helicobacter pylori infection: evaluation of laboratory detection of h. pylori pcr and anti-h. pylori antibodies by elisa. 3) ... | 1994 | 8022072 |
| [is ventricular lymphoma an infectious disease?]. | 1994 | 8023415 | |
| non-steroidal anti-inflammatory drugs (nsaid) cause gastrointestinal ulcers mainly in helicobacter pylori carriers. | in a prospective study from august to the end of december 1992, all patients with endoscopically confirmed gastric or duodenal ulcers were examined for the presence of h. pylori infection by means of an antibody blood test and gastric biopsy. after a detailed history had been taken the patients were divided into two groups. group i (n = 40) was made up of patients taking nsaids. group ii (n = 42) consisted of non-nsaid patients. a control group was formed of nsaid patients with no marked intesti ... | 1994 | 8023522 |
| medium- and high-dose omeprazole plus amoxicillin for eradication of helicobacter pylori in duodenal ulcer disease. | the purpose of the present study was to investigate the helicobacter pylori eradication potency of combined amoxicillin-omeprazole treatment in patients with duodenal ulcer disease and to compare the efficacy of two omeprazole and amoxicillin doses concerning h. pylori eradication, ulcer healing, pain relief, and safety. ninety patients with active h. pylori-positive (culture and/or histology) duodenal ulcer disease were randomly treated with either omeprazole 20 mg twice a day plus amoxicillin ... | 1994 | 8026260 |
| helicobacter pylori infection in children. is there specific symptomatology? | helicobacter pylori is an established cause of chronic-active gastritis in both adults and children. however, it is unclear whether h. pylori causes specific clinical symptoms. therefore, the spectrum of clinical symptoms associated with h. pylori infection was studied in consecutive symptomatic children undergoing diagnostic endoscopy at two pediatric centers, using a structured questionnaire. in toronto, canada, 86 of 97 eligible children were enrolled into the study and in limerick, ireland, ... | 1994 | 8026261 |
| role of helicobacter pylori in cirrhotic patients with peptic ulcer. a serological study. | helicobacter pylori was found to be a promoter factor of peptic ulcer that has an incidence higher in patients with hepatic cirrhosis. to clarify the role between h. pylori and peptic ulcer in patients with hepatic cirrhosis, a serological test (elisa test, hel-p, amrad, australia), was used to measure the presence of h. pylori of patients with hepatic cirrhosis. within two years, 108 cirrhotic patients who had received a panendoscopic examination were enrolled in this study. there were 79 males ... | 1994 | 8026271 |
| animal and public health implications of gastric colonization of cats by helicobacter-like organisms. | the bacterial genus helicobacter contains a number of species which colonize the gastric mucosa of mammals. natural and/or experimental gastric pathology has been correlated with colonization in humans and a wide variety of animal species. historical reports in the literature suggest that a high percentage of cats are colonized by large, spiral, gastric helicobacter-like organisms (ghlos). one of these bacteria (helicobacter felis) has been isolated on artificial media and has experimentally cau ... | 1994 | 8027308 |
| ribotyping patterns and emergence of metronidazole resistance in paired clinical samples of helicobacter pylori. | metronidazole-susceptible pretreatment isolates and metronidazole-resistant posttreatment isolates of helicobacter pylori from 11 patients before and after unsuccessful triple therapy consisting of metronidazole, amoxicillin, and colloidal bismuth subcitrate were studied. ribotyping (rrna gene restriction pattern analysis) of the isolates demonstrated that all patients except one had identical digest patterns for pre- and posttreatment isolates. | 1994 | 8027316 |
| diagnosis of helicobacter pylori in biopsy specimens. | 1994 | 8027385 | |
| helicobacter pylori gastritis and primary gastric non-hodgkin's lymphomas. | to evaluate further the relation between gastric malignant lymphoma of the mucosa associated lymphoid tissue (malt) and helicobacter pylori. | 1994 | 8027397 |
| activity of omeprazole on helicobacter pylori and relation to toxicity of strains. | to see whether the activity of omeprazole on helicobacter pylori is associated with toxicity of strains; to determine whether omeprazole inhibited vacuolisation of cells in culture induced by h pylori cytotoxin and by ureas, and if omeprazole prevented h pylori motility. | 1994 | 8027398 |
| dyspepsia in general practice: psychological findings in relation to helicobacter pylori serum antibodies. | questionnaire data based on traditional concepts for measuring hypochondriasis and depression were related to serological data on helicobacter pylori antibodies in 110 of 130 consecutive patients, aged 18-65 yr, consulting for dyspeptic symptoms in general practice. of the patients thirty-seven (33.6%) and seventy-three (66.4%) were classified as h. pylori positives and h. pylori negatives, respectively, the h. pylori positive patients being significantly older than h. pylori negative patients. ... | 1994 | 8027963 |
| [endoscopic hemostasis in stomach and duodenum]. | endoscopic hemostasis in cases of acute upper gastrointestinal bleeding may be achieved by various methods with comparable initial results, nevertheless the frequency of re-bleeding is different in regard to the techniques. the frequency of re-bleeding may be reduced by the application of fibrin tissue sealant, the eradication of helicobacter pylori and by daily endoscopic controls. the use of big channel endoscopes makes intragastral survey easier, and beyond that endoscopic doppler-ultrasound ... | 1994 | 8029592 |
| [antibiotic therapy of duodenal ulcer]. | 1994 | 8016943 | |
| [prevention of duodenal ulcer recurrence with penicillin]. | the aim of this study was to test the hypothesis that infection with helicobacter pylori is essential for recurrence of duodenal ulcer. we performed a randomized controlled trial of the relapse rate of duodenal ulcer during 12 weeks treatment with penicillin v or placebo in 170 out-patients from five centres. the relapse rate was 9% during treatment with penicillin and 50% with placebo, p < 0.0001. it is concluded that infection with penicillin-sensitive bacteria, i.e. h. pylori, plays an import ... | 1994 | 8016944 |
| [helicobacter pylori and ulcer disease. reflections on diagnosis and treatment of h. pylori infections in duodenal ulcer and stomach ulcer]. | 1994 | 8016956 | |
| more convenient 13c-urea breath test modifications still meet the criteria for valid diagnosis of helicobacter pylori infection. | 13c-urea breath tests (ubt) were performed in 217 patients with epigastric symptoms to assess (a) the validity of shorter intervals of breath sample collection and (b) of the non-fasting state on diagnosing h. pylori infection and to evaluate (c) a more simple sampling method. (a) in 186 patients, breath samples were taken before and at 10, 20, 30, 40, 50, 60, 90, and 120 minutes after ingestion of 75 mg 13c-urea. 13c-enrichment was measured by isotope ratio mass spectrometry [delta/1000] and th ... | 1994 | 8017093 |
| misoprostol for the treatment of chronic erosive gastritis: a double-blind placebo-controlled trial. | to assess the efficacy of misoprostol for the treatment of chronic erosive gastritis and associated symptoms. | 1994 | 8017357 |
| mini-dose (1-microci) 14c-urea breath test for the detection of helicobacter pylori. | to develop and evaluate a mini-dose (1-microci) 14c-urea breath test (ubt), using a simplified protocol. | 1994 | 8017360 |
| bismuth-free triple therapy for eradicating helicobacter pylori and reducing the gastric ulcer recurrence rate. | the goals of this study were to assess the effectiveness of a new triple therapy consisting of amoxicillin and metronidazole with plaunotol in the eradication of helicobacter pylori infection in humans, and to determine whether this treatment regimen reduces the rate of recurrence of gastric ulcer in patients infected with h. pylori, without instituting maintenance therapy with h2-receptor antagonists. | 1994 | 8017361 |
| congestive gastropathy: factors influencing development, endoscopic features, helicobacter pylori infection, and microvessel changes. | to study 1) the factors influencing the development of congestive gastropathy (cg) in patients with portal hypertension (pht), 2) the changes in gastric microvessels in patients with pht with and without cg, and 3) to determine whether helicobacter pylori plays any role in the pathogenesis of cg. | 1994 | 8017362 |
| helicobacter cinaedi-associated bacteremia and cellulitis in immunocompromised patients. | to define the clinical spectrum of illness associated with helicobacter cinaedi infection in the united states and to determine associated epidemiologic risk factors and optimal laboratory methods for recovery of h. cinaedi. | 1994 | 8017741 |
| laparoscopic vagotomy: an operation for the 1990s? | 1994 | 8017819 | |
| laparoscopic vagotomy: an operation for the 1990s? | 1994 | 8017820 | |
| relation of helicobacter pylori infection and coronary heart disease. | there is evidence suggesting that early life experience may influence adult risk of coronary heart disease (chd). chronic bacterial infections have been associated with chd. | 1994 | 8011406 |
| gastrospirillum hominis-associated gastritis: the first reported case in japan. | tightly coiled spiral micro-organisms (gastrospirillum hominis), distinct from helicobacter pylori, were found in the gastric mucosa of a 66-year-old man with a 4-month history of intermittent epigastric pain. the organisms were distributed in the antral mucosa, which showed erosive gastritis; histologically, the affected mucosa presented moderate to severe chronic gastritis with focal neutrophil infiltration. after a 2-week administration of cimetidine, his symptoms resolved and the active infl ... | 1994 | 8012509 |
| in vitro activity of rifaximin against helicobacter pylori. | 1994 | 8013497 | |
| [diagnostic difficulties in barrett mucosa. borderline forms of barrett esophagus]. | 1994 | 8013774 | |
| genome conservation in helicobacter mustelae as determined by pulsed-field gel electrophoresis. | genomic dna from 15 strains of helicobacter mustelae was subjected to pulsed-field gel electrophoresis (pfge) after digestion with paci and sfii. h. mustelae genome dna appeared very similar in all strains examined, whether isolated from ferrets or mink or from animals bred in either the usa or in the uk. the h. mustelae genome size was estimated to be 1.7 mb, similar in size to that of h. pylori. a minor difference in paci pfge pattern and genome size was observed between rifampicin-resistant a ... | 1994 | 8013879 |
| helicobacter pylori infection and follicular gastritis in childhood. | 1994 | 8013955 | |
| salty food intake and risk of helicobacter pylori infection. | to clarify the risk factors for helicobacter pylori infection, which is considered to play an etiologic role in atrophic gastritis, duodenal ulcer and gastric cancer, various parameters including diet and socioeconomic characteristics were compared between h. pylori-infected and non-infected men. in a cross-sectional study of 634 men aged 40 to 49 years selected randomly from five areas with different rates of gastric cancer mortality, 474 of 628 men evaluated were positive for igg antibody agai ... | 1994 | 8014104 |
| neutrophil activation by helicobacter pylori lipopolysaccharides. | helicobacter pylori-induced release of toxic substances by neutrophils could be of potential importance in the pathogenesis of gastroduodenal inflammatory diseases. lipopolysaccharide (lps) has the ability to induce neutrophil activation at very low concentrations. neutrophil oxidative metabolism and enzyme release were assessed after stimulation of neutrophils with various preparations of lps from h. pylori and compared with that obtained with salmonella typhimurium lps. no direct activation of ... | 1994 | 8014489 |
| gastric mucosal cell densities in helicobacter pylori-positive and -negative dyspeptic children and healthy controls. | the densities (cells/mm2) of gastric inflammatory cells were determined. fifty-four dyspeptic children, of whom 12 had proven helicobacter pylori infection, were compared with 13 healthy children. the mean antral lymphocyte density for healthy children was 604 cells/mm2 (95% confidence interval [95% ci], 414-793); for plasma cells, 411 (95% ci, 274-548); for neutrophils, 0; and for eosinophils, 4 (95% ci, -4-13). h. pylori-positive children had significantly higher mean densities of all cell typ ... | 1994 | 8014761 |
| endoscopic and histologic resolution of gastric pseudolymphoma (reactive lymphoid hyperplasia) following treatment with bismuth and oral antibiotics. | gastric pseudolymphoma is a rare disorder of unknown etiology that can undergo transformation into malignant lymphoma. this report describes the first case of a gastric pseudolymphoma associated with helicobacter pylori infection that underwent complete clinical, endoscopic, and histologic resolution following treatment with bismuth subsalicylate, amoxicillin, and metronidazole. the eradication of helicobacter pylori may have eliminated ongoing antigenic stimulation that has previously been post ... | 1994 | 7995181 |
| helicobacter pylori: populations and cohorts. | 1994 | 7996012 | |
| [occurrence of helicobacter pylori strains resistant to metronidazole]. | this study describes results of in vitro examination of susceptibility to metronidazole of clinical strains of helicobacter pylori isolated from patients with gastritis. the susceptibility was determined by disc diffusion test. h. pylori was isolated from 44 (67.7%) of patients. thirty six (81.8%) of the strains were resistant to metronidazole: 17 (85%) from 20 strains isolated from women and 19 (79.2%) from 24 strains isolated from men. this study emphasises the importance of monitoring the dru ... | 1994 | 7996934 |
| familial predisposition to precancerous gastric lesions in a high-risk area of china. | aggregation of intestinal metaplasia and dysplasia was investigated among families participating in a population-based gastroscopic screening survey in an area of china with one of the world's highest rates of stomach cancer. the prevalence of gastric dysplasia was significantly increased among those with dysplasia among siblings or spouses, but not parents. the odds of dysplasia were nearly doubled if an eldest brother or a spouse was affected. sibling and spousal associations for intestinal me ... | 1994 | 8000295 |
| characteristics of helicobacter pylori growth in a defined medium and determination of its amino acid requirements. | a defined medium has been developed for helicobacter pylori that gives growth characteristics (growth rate, maximum cell number and maximum colony-forming-unit count) comparable to those in a complex medium (isosensitest broth + 5%, v/v, foetal bovine serum). differences found in the death rate reflected a partial (50%) conversion to a coccoid cell form of the organism in the stationary and death phase in the defined medium, versus the almost complete (> 99%) conversion seen in the complex mediu ... | 1994 | 8000535 |
| optimized conditions for the fermentation of helicobacter pylori and production of vacuolating cytotoxin. | we report here improvements to the growth media and fermentation conditions which result in a substantial increase of helicobacter pylori growth and in the enhanced production of vacuolating cytotoxin. addition of glucose to the medium resulted in the increase of cell yield, cell viability and a significant improvement in the production of vacuolating cytotoxin. | 1994 | 8001770 |
| helicobacter pylori and gastro-oesophageal reflux disease--a prospective study. | in a prospective evaluation of the relationship between helicobacter pylori infection and gastro-oesophageal reflux disease (gord), 93 consecutive patients (47 female: 46 male: mean age, 46 years: range 13-93) with symptoms and endoscopic evidence of gord were studied. a total of 50 patients (54%) were h. pylori-positive on gastric antral biopsies. no significant correlation was detected between h. pylori status and grade of oesophagitis. the prevalence of h. pylori infection showed a gradual in ... | 1994 | 8002262 |
| genetic, enzymatic, and pathogenic studies of the iron superoxide dismutase of campylobacter jejuni. | campylobacter jejuni is a microaerobic bacterium that produces an acute, self-limiting, watery or bloody diarrhea in humans. little is known about how c. jejuni causes disease or even what specific capabilities it requires for survival in vivo. the enzyme, superoxide dismutase (sod), which catalyzes the breakdown of superoxide radicals to hydrogen peroxide and dioxygen is one of the bacterial cell's major defense mechanisms against oxidative damage. a pcr-based search for sod genes in c. jejuni ... | 1994 | 8005660 |
| pre-formed urease activity of helicobacter pylori as determined by a viable cell count technique--clinical implications. | the pre-formed urease activity of three nctc reference strains and five clinical isolates of helicobacter pylori was determined at room temperature (21 degrees c) and 37 degrees c by a viable cell count technique with a conventional urea slope test (christensen's agar) as well as the commercial clo-test. the urease activity of two gastroduodenal commensals, proteus mirabilis and klebsiella pneumoniae, was also tested. h. pylori strains produced positive reactions with viable cell counts of 10(6) ... | 1994 | 8006937 |
| fumarate reductase of helicobacter pylori--an immunogenic protein. | an immunogenic protein with an apparent mol. wt of 80 kda that was recognised by 55% of sera from patients infected with helicobacter pylori in western blots was found in butanol extracts of h. pylori membranes. the n-terminal amino-acid sequence of the 80-kda protein showed 80% identity with the n-terminal sequence of subunit a of the fumarate reductase of wolinella succinogenes, suggesting the existence of a fumarate reductase in h. pylori. the membrane fraction of h. pylori catalysed succinat ... | 1994 | 8006945 |
| nih consensus conference. helicobacter pylori in peptic ulcer disease. nih consensus development panel on helicobacter pylori in peptic ulcer disease. | 1994 | 8007082 | |
| the acid test. making clinical sense of the consensus conference on helicobacter pylori. | 1994 | 8007084 | |
| laparoscopic vagotomy: an operation for the 1990s? | 1994 | 7912490 | |
| seroprevalence study of helicobacter pylori infection in patients with gastroduodenal diseases. | to investigate helicobacter pylori (h. pylori) infection in subjects with and without gastroduodenal diseases in taiwan, igg antibodies to h. pylori were examined in 136 healthy volunteers, 101 patients with non-ulcer dyspepsia, 122 gastric ulcers, 119 duodenal ulcers, and 161 gastric adenocarcinomas. the seropositivity was highest in duodenal ulcers (87.4%) (p < 0.001, as compared to healthy volunteers), followed by gastric ulcers (76.2%) (p < 0.01, as compared to healthy volunteers), but simil ... | 1994 | 7912582 |
| helicobacter pylori and the heart. | 1994 | 7912762 | |
| canine-to-human transmission of gastrospirillum hominis. | 1994 | 7912779 | |
| drugs for treatment of peptic ulcers. | 1994 | 7912812 | |
| high ige serum levels and "peptic" ulcers: clinical and functional approach. | the prevalence of high total ige serum levels was evaluated in 232 consecutive patients suffering from peptic ulcer. twenty-one percent of the patients presented total ige serum levels above 200 ku/l compared with the 5% found in a healthy control population (p < 0.004). similar prevalence was found in gastric and/or duodenal ulcers. no significant differences in the duration of the disease, smoking habits, familiarity for peptic ulcer, symptomatology and frequency of complications were observed ... | 1994 | 7912969 |
| single and multiple strain colonization in patients with helicobacter pylori-associated gastritis: detection by macrorestriction dna analysis. | helicobacter pylori isolates from 18 patients were examined by macrorestriction dna analysis to determine whether > or = 2 strains can coexist in the human stomach. four biopsy samples from different sites in each patient's stomach were cultured, and 12-14 clones of h. pylori per patient were analyzed. dna of 15 of the 18 isolates was digestible: 12 by noti and 3 by nrui. within 14 of these digestible isolates, the patterns of all clones were identical. the isolate of 1 patient showed two digest ... | 1994 | 7913483 |
| effect of eradication of helicobacter pylori on gastric epithelial cell proliferation. | helicobacter pylori is associated with b-type gastritis, duodenal ulcer disease, and possibly gastric carcinoma. the object of this study was to assess the effect of eradication of h. pylori infection on gastric epithelial cell proliferation. | 1994 | 7913636 |
| comparison of pcr-based restriction length polymorphism analysis of urease genes with rrna gene profiling for monitoring helicobacter pylori infections in patients on triple therapy. | multiple isolates of helicobacter pylori from antral biopsies of nine patients were examined by dna fingerprinting. analysis of rrna gene patterns and haeiii restriction fragment length polymorphism of pcr-amplified urease genes were compared and used to study colonization before and after failed triple therapy. h. pylori isolates from a single biopsy shared the same haeiii dna fingerprint regardless of the isolation method (plate or broth). dna pattern types of paired strains of h. pylori were ... | 1994 | 7914204 |
| [diabetes, gastric parietal cell antibodies and helicobacter pylori]. | 1994 | 7951843 | |
| detection of serum igg antibody against helicobacter pylori from childhood in a japanese population. | epidemiological evidence has shown that seropositivity for helicobacter pylori in the stomach is positively correlated with the incidence of gastric cancer. in this study, we investigated serum igg antibody against h. pylori in asymptomatic japanese subjects by an enzyme-linked immunoassay (elisa) method (serion, wuerzburg, germany). we noted two characteristics: (1) seropositivity was seen in 41% of individuals aged less than 1 year, and in 9% of those aged 1-2 years, indicating the possibility ... | 1994 | 7951848 |
| [a complex method of detection of helicobacter pylori in patients with duodenal ulcer]. | a method for measurements of blood antigen-binding lymphocytes sensitized to helicobacter antigens is suggested. use of this method together with urease test will improve helicobacter infection detection rate by 22%. | 1994 | 7953111 |
| [is ulcer disease an infectious disease?]. | 1994 | 7956776 | |
| [the modified 13c-urea breath test in the diagnosis of helicobacter pylori colonization of the gastric mucosa]. | the value of a modified 13c-urea breath test for the detection of helicobacter pylori was analysed in a prospective study of 50 consecutive patients (28 women, 22 men, aged 20-90 years) with unknown helicobacter pylori status about to undergo upper intestinal endoscopy. four biopsies each were obtained in each patient from the antrum and the body of the stomach and examined for helicobacter pylori infection of the gastric mucosa histologically (haematoxylin-eosin and giemsa stain), with the rapi ... | 1994 | 7956797 |
| adhesion of helicobacter pylori and escherichia coli to human and bovine surface mucus cells in vitro. | helicobacter pylori shows in vivo a specific affinity for epithelial surface mucus cells (smc) of the human stomach. we studied the in vitro adhesion of five different h. pylori strains and one non-pathogenic escherichia coli-strain to (a) human antral smc, obtained during gastroscopy; (b) human tumour smc, from a carcinoma cell line (crl 1739 ags); and (c) bovine smc, obtained from the abomasum. smc of different origin were characterized by means of electron microscopy and immunohistochemistry, ... | 1994 | 7957501 |
| a descriptive follow-up study on helicobacter pylori infection before and after exposition to a war area. | one hundred and thirty asymptomatic irish soldiers were studied before and after a 6-month peace duty in lebanon (unifil), to assess the overall prevalence of helicobacter pylori infection, relation with age, rank and education, and any increased risk of developing h. pylori infection in a cohort of asymptomatic people temporarily exposed to low levels of sanitation. enzyme linked immunosorbent assays (elisa) of specific igg were performed, at the end of the research, on blood samples taken 1 mo ... | 1994 | 7957781 |
| helicobacter pylori in peptic ulcer disease. | 1994 | 7958122 | |
| isolation of helicobacter pylori from feces of patients with dyspepsia in the united kingdom. | epidemiological studies suggest that fecal-oral spread of helicobacter pylori potentially represents an important route of infection. however, the bacterium has never been isolated from feces of adults in the developed world. this study attempted to isolate h. pylori from stool specimens donated by 36 adults from the united kingdom who had dyspepsia. | 1994 | 7958677 |
| regression of gastric lymphoma of mucosa-associated lymphoid tissue with antibiotic therapy for helicobacter pylori. | regression of low-grade b cell gastric lymphoma of mucosa-associated lymphoid tissue after eradication of helicobacter pylori with antibiotic therapy was recently shown in a small number of patients with low-volume tumors. a patient with a > 10 cm nodular gastric mucosa-associated lymphoid tissue lymphoma that caused hematemesis and weight loss is described. antibiotic therapy of h. pylori resulted in full clinical recovery and resolution of the mass lesion and morphological features of lymphoma ... | 1994 | 7958698 |
| helicobacter pylori and early gastric cancer. | the relation between helicobacter pylori, intestinal metaplasia, and early gastric cancer was studied by examining gastrectomy specimens from 31 intestinal type and 22 diffuse type carcinomas. a total of 298 patients with antral gastritis were used as controls. atrophic changes and intestinal metaplasia were significantly more common in intestinal type early gastric cancer compared with diffuse type early gastric cancer (p < 0.05 and p < 0.001, respectively). h pylori was found in 61.3% of intes ... | 1994 | 7959189 |
| rebamipide, a novel antiulcer agent, attenuates helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. | the effect of rebamipide, a novel antiulcer compound, on helicobacter pylori activated neutrophil dependent in vitro gastric epithelial cell injury was investigated. luminol dependent chemiluminescence (chl), which detects toxic oxidants from neutrophils exhibited a 12-fold increase when the bacterial suspension of h pylori was added to the isolated human neutrophils. this change was significantly attenuated by rebamipide at a concentration less than 1 mm, showing that rebamipide may inhibit oxi ... | 1994 | 7959190 |
| gastric t lymphocyte responses to helicobacter pylori in patients with h pylori colonisation. | helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. the aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in patients with h pylori colonisation. sixty five dyspeptic patients attending for endoscopy were studied; 35 of these were h pylori positive and 30 h pylori negative as assessed by culture, histology, and rapid urease test. h pylori antigen was capable of stimulating peripheral bloo ... | 1994 | 7959191 |
| low prevalence of helicobacter pylori in inflammatory bowel disease: association with sulphasalazine. | the prevalence of igg antibodies to helicobacter pylori was examined in 110 patients with inflammatory bowel disease (ibd) (63 ulcerative colitis, 47 crohn's disease) and compared with 100 age and sex matched control patients. the overall prevalence of h pylori seropositivity in the ibd patients was 22%, which was significantly less than that of 52% in the controls (p < 0.002). there was no difference in prevalence between ulcerative colitis and crohn's patients. the low seropositivity in the ib ... | 1994 | 7959192 |
| why is peptic ulcer now a disease? | 1994 | 7959215 | |
| fall in the prevalence of chronic gastritis over 15 years: analysis of outpatient series in finland from 1977, 1985, and 1992. | to investigate whether the occurrence of chronic gastritis (and helicobacter pylori acquisition) has changed in finland in the past 15 years, the prevalence rates of chronic gastritis in biopsy specimens in consecutive series of outpatients (aged 20 or more) who had undergone diagnostic upper gastrointestinal endoscopy in 1977 (702 patients), 1985 (1309 patients), or 1992 (1447 patients) were compared. the prevalences of gastritis in these series were also compared with that in a random sample ( ... | 1994 | 7959219 |
| histological assessment of the sydney classification of endoscopic gastritis. | to determine the significance of the endoscopic classification of gastritis proposed by a working party at the world congress of gastroenterology in sydney 1990, 167 patients undergoing upper alimentary endoscopy were prospectively assessed by comprehensive endoscopic and histological methods. ninety eight patients had endoscopic mucosal changes of gastritis according to the sydney classification. twenty six (27%) of these had histologically normal biopsy specimens. this was not statistically si ... | 1994 | 7959220 |
| interaction of helicobacter pylori and its fatty acids with parietal cells and gastric h+/k(+)-atpase. | helicobacter pylori and the fatty acids produced by this organism were compared for their acid inhibitory activity in isolated parietal cells and their interaction with gastric h+/k(+)-atpase. h pylori (intact organisms, sonicates, methanolic extracts, and extracts from culture medium) and the fatty acids cis 9,10-methyleneoctadecanoic acid and tetradecanoic acid inhibited at fairly high concentrations histamine- and dibutyryl cyclic adenosine monophosphate stimulated acid production in isolated ... | 1994 | 7959221 |
| [eradication of helicobacter pylori. effectiveness of a combination of ranitidine and metronidazole/roxithromycin]. | thirty-five patients with endoscopically confirmed duodenal ulcer, histological evidence of helicobacter pylori, and a history of at least two symptomatic recurrent ulcers consecutively attending a doctor's office were entered into a study investigating the eradication of helicobacter pylori. | 1994 | 7959514 |
| [studies on gastric mucosal cell injury induced by helicobacter pylori]. | the cause of gastric mucosal cell injury induced by helicobacter pylori (h. pylori) was investigated in vitro using gastric mucosal cells derived from the stomach of male japanese white rabbits. in order to evaluate the contribution of potent urease activity of h. pylori to gastric mucosal cell injury, supernatant of h. pylori bacterial pellet solubilized in a 1.0% solution of n-octyl-glucoside, the h. pylori extracts, was added to the rabbit gastric mucosal cell suspension. cell injury was expr ... | 1994 | 7959595 |
| recent developments in the medical management of peptic ulcer disease. | 1994 | 7960641 | |
| caga/cytotoxic strains of helicobacter pylori and interleukin-8 in gastric epithelial cell lines. | to investigate: (1) whether helicobacter pylori directly induces interleukin-8 (il-8) message expression and protein secretion in established gastric epithelial cell lines; and (2) if caga/cytotoxin positive and negative strains of h pylori differ in their ability to induce epithelial il-8. | 1994 | 7962609 |
| electron microscopic study of association between helicobacter pylori and gastric and duodenal mucosa. | to study the ultrastructural appearances of helicobacter pylori in antral and duodenal biopsy specimens and its relation with the epithelial cells. | 1994 | 7962619 |
| histological study of chronic gastritis from the united arab emirates using the sydney system of classification. | to determine the prevalence of helicobacter pylori in five main nationality groups with gastric ulcer, duodenal ulcer, and non-ulcer dyspepsia; and to determine the histopathological types of gastritis and assess the graded variables of helicobacter associated gastritis. | 1994 | 7962649 |
| helicobacter pylori infections in the developing world. summary of a workshop organized at the international centre for diarrhoeal disease research, bangladesh (icddr,b) from february 2 to 4, 1993. | 1994 | 7963348 | |
| helicobacter pylori infection in gastroenterology clinic personnel. | 1994 | 7963465 | |
| helicobacter pylori and the pathogenesis of duodenal ulcer. | in summary, it appears that the role of h. pylori in duodenal ulcerogenesis is not directly associated with acid hypersecretion. similarly, it seems unlikely that h. pylori-induced autoimmune injury is an important mechanism in duodenal ulcerogenesis. an essential question remaining is whether h. pylori infection of areas of gastric metaplasia in the duodenum is essential to ulcer pathogenesis. the low yield of h. pylori in duodenal biopsy studies argues against this mechanism. it is possible th ... | 1994 | 7964119 |
| do clinicians accept the role of helicobacter pylori in duodenal ulcer disease: a survey of european gastroenterologists and general practitioners. | to examine to what extent clinicians in europe accepted the theory of the casual role of helicobacter pylori (h.pylori) in duodenal ulcer disease in the year 1992, and to what extent the theory had influenced their diagnostic and therapeutic habits in the management of duodenal ulcer patients at that time. | 1994 | 7964425 |
| symptomatic helicobacter pylori infection in young patients with severe neurologic impairment. | helicobacter pylori infection was identified in five patients with profound neurologic impairment who were undergoing evaluation for gastrointestinal symptoms, and it was subsequently identified in 7 of 61 patients with symptoms whose condition was evaluated prospectively. institutionalized patients were at greater risk of infection. treatment of h. pylori infection resulted in symptomatic improvement for the majority of patients. | 1994 | 7965428 |
| recurrent abdominal pain of gastrointestinal origin. | 1994 | 7965471 | |
| evolution of helicobacter pylori positivity in infants born from positive mothers. | to evaluate the mother-child transmission of anti-helicobacter pylori antibodies, we investigated 562 pregnant women by means of a commercially available second-generation enzyme-linked immunosorbent assay for the detection of anti-h. pylori igg (malakit helicobacter pylori). one hundred twenty-eight of the 562 women had a positive serology for h. pylori. 13c-urea breath tests were performed in 85 seropositive and in 65 randomly selected seronegative subjects. these breath tests were positive in ... | 1994 | 7965484 |
| gastric lymphoma. | 1994 | 7966123 | |
| study on the association between helicobacter pylori infection and the pathogenesis of gastric cancer by using molecular biological techniques. | recent epidemiological observations have indicated that the role of helicobacter pylori (hp) infection in the pathogenesis of gastric cancer is an important but unresolved issue. we used the polymerase chain reaction, a sensitive and specific assay, to detect the hp infection in gastric biopsy specimens and examined the correlations between hp infection and point mutation at 12 codon of h-ras oncogene, overexpression of ras p21 and dna content. the results showed that the mutation rate of h-ras ... | 1994 | 7966516 |
| [synthesis of glycoproteins by mucosa of gastric antrum in chronic gastritis b]. | the tissue culture and autoradiography techniques were used to study the effect of infiltration by inflammatory cells and of hp infection on the synthesis of glycoproteins by the gastric antrum. the results showed that in active phase of gastritis, the synthesis of glycoprotein was increased but no correlation between hp infection and synthesis of glycoprotein was noted. the mechanism of increased synthesis in chronic gastritis was discussed. it is suggested that the inflammatory cells and media ... | 1994 | 7966517 |
| [helicobacter pylori therapy with omeprazole and clarithromycin: current status]. | clarithromycin and its 14-oh-metabolite are highly effective against helicobacter pylori in vitro. this drug is acid stable and soluble and reaches considerable concentrations in the gastric mucosa and the mucus layer after oral administration. several studies have meanwhile demonstrated that combined treatment with omeprazole and clarithromycin may eradicate. h. pylori infection in a remarkable proportion of treated patients. on the basis of the results of a recently published randomized double ... | 1994 | 7968179 |
| the role of endogenous ulcerogenic mediators in the pathogenesis of peptic ulcer. | the pathogenetic mechanisms of different types of peptic ulcer are still unclear. extensive investigations have been focused on the identification of potential endogenous ulcerogenic mediators in animals and men. these studies are important in the development of a better therapeutic agent, either to prevent or to cure peptic ulcer in humans. several endogenous substances have been identified and are reported to be involved in the production of gastrointestinal lesions in animals. also these subs ... | 1994 | 7968223 |
| characterization of microbial host receptors. | 1994 | 7968622 | |
| rate of occurrence of helicobacter pylori in patients with gastroduodenal pathology: pilot research. | in an attempt to establish the etiologic role of helicobacter pylori (h. pylori) in gastric and/or duodenal pathology, 169 patients were tested and compared with a control group of 25 healthy subjects, for a total of 194 subjects. data on sex, age, familiarity, smoking, coffee and alcohol habits were collected and each patient underwent histological, microbiological and immunological tests. 80 (41.2%) subjects were found positive to h. pylori. this bacterium was detected in 53.3% of patients wit ... | 1994 | 7968657 |
| the current status of helicobacter pylori as a pathogen in upper gastrointestinal tract. | 1994 | 7970364 | |
| helicobacter pylori infection. when and in whom is treatment important? | since the discovery of helicobacter pylori 10 years ago, its role in peptic ulcer disease has been recognized. now the questions are, what is the best way to eradicate the organism, and which patients should receive treatment? dr anderson explores the issues concerning h pylori infection in patients with recurrent ulcers and describes the most reliable treatment regimens available. | 1994 | 7971611 |
| use of nsaids. an assault on the upper gastrointestinal tract. | nonsteroidal anti-inflammatory drugs (nsaids) often cause gastric and, to a lesser extent, duodenal injury. patient care can be improved if physicians are familiar with the risk factors and have a good understanding of (1) the actions of various nsaids, (2) mucosal protection strategies, and (3) options for treatment of damage once it occurs. it is hoped that with careful selection of an nsaid and use of cytoprotective agents, treatment of these injuries will be necessary less often in the futur ... | 1994 | 7971613 |
| appropriate acid suppression in the treatment of acid-related conditions. | gastric acid is involved in the pathogenesis of duodenal ulcer, gastric ulcer and gastro-oesophageal reflux disease. although levels of acid secretion may not be abnormally high in patients with these conditions, pharmacological suppression of acid secretion is associated with healing of mucosal defects and maintenance of healing in the long term. in the case of duodenal ulcer, this was demonstrated before the understanding of the importance of helicobacter pylori infection. there is a considera ... | 1994 | 7972343 |
| gastritides, gastropathies, and polyps unique to the stomach. | this article discusses a variety of non-neoplastic conditions that involve the stomach. nonspecific gastritis and helicobacter gastritis are discussed in detail as are other infectious diseases and the forms of hypertrophic gastritis. non-neoplastic polyps unique to the stomach, hyperplastic polyps, and fundic gland polyps are also covered. | 1994 | 7972709 |
| gastrospirillum hominis in acute gastric erosion. | gastrospirillum hominis is a spirochete that has been described in association with chronic gastritis and duodenal ulcers. we report the case of a patient having acute gastric erosion in whom biopsy showed abundant organisms. the erosion resolved while the patient was receiving sucralfate and omeprazole therapy. we discuss the histopathology and mode of transmission of g hominis, along with the role of antibiotic therapy. | 1994 | 7973903 |
| gastrointestinal bleeding in stroke. | patients with ischemic or hemorrhagic stroke are at risk for systemic complications. the reasons why gastrointestinal bleeding occurs after stroke are unknown and have intuitively been attributed to stress ulcers. no study to date has addressed causes of gastrointestinal hemorrhage in stroke. | 1994 | 7974536 |