Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [recurrent respiratory papillomatosis: a cause of progressive respiratory distress]. | a 5-year-old girl was brought to the emergency department because of respiratory distress of 3 months' evolution that had worsened over the previous 3 weeks. cervical radiograph and cervical computerized axial tomography showed an endolaryngeal mass almost completely occluding the airway. urgent laryngoscopy revealed an endolaryngeal fleshy mass, which was excised during the procedure. histological diagnosis was laryngeal papilloma. although infrequent in children, laryngeal papilloma is the mos ... | 2001 | 11730592 |
| human papillomavirus type 7 and butcher's warts. | 2001 | 11735725 | |
| treatment of human papilloma virus in a 6-month-old infant with imiquimod 5% cream. | a healthy female infant was diagnosed with genital warts at six months of age. she was the product of an uncomplicated vaginal delivery to a mother who was diagnosed with genital warts during the pregnancy, but did not undergo any treatment. the infant's warts were clinically resolved following a three week course of 5% imiquimod cream, an immunomodulating agent that has been demonstrated to be a potent inducer of several cytokines promoting an antiviral cell-mediated immune response. | 2001 | 11737697 |
| clinicopathologic characterization of squamous-cell carcinoma arising from pilonidal disease in association with condylomata acuminatum in hiv-infected patients: report of two cases. | pilonidal disease is a common acquired condition believed to arise from penetration of short hairs into the subcutaneous tissue that induces a cyst or sinus formation. malignant degeneration is rare and is typically seen only after decades of antecedent disease presence. condylomata acuminatum in association with pilonidal disease have been described in two prior case reports, however, the coexistence of condyloma with pilonidal disease complicated by malignant degeneration has not been previous ... | 2001 | 11742179 |
| enhancement of capsid gene expression: preparing the human papillomavirus type 16 major structural gene l1 for dna vaccination purposes. | expression of the structural proteins l1 and l2 of the human papillomaviruses (hpv) is tightly regulated. as a consequence, attempts to express these prime-candidate genes for prophylactic vaccination against papillomavirus-associated diseases in mammalian cells by means of simple dna transfections result in insufficient production of the viral antigens. similarly, in vivo dna vaccination using hpv l1 or l2 expression constructs produces only weak immune responses. in this study we demonstrate t ... | 2001 | 11533183 |
| high frequency of loss of heterozygosity in vulval intraepithelial neoplasia (vin) is associated with invasive vulval squamous cell carcinoma (vscc). | vulval intraepithelial neoplasia (vin) is thought to be the premalignant phase of human papillomavirus (hpv)-associated vulval squamous cell carcinoma (vscc). various molecular events have been suggested as markers for progression from vin to vscc, but loss of heterozygosity (loh) in vulval neoplasia has rarely been studied in this context. we performed loh analysis by polymerase chain reaction (pcr) amplification of polymorphic microsatellite markers at 6 chromosomal loci (17p13-p53, 9p21-p16, ... | 2001 | 11745496 |
| papillary immature metaplasia of the uterine cervix: a report of 5 cases with an emphasis on the differential diagnosis from reactive squamous metaplasia, high-grade squamous intraepithelial lesion and papillary squamous cell carcinoma. | papillary immature metaplasia (pim) is a distinctive exophytic lesion of the uterine cervix and shares some histologic and cytologic features with ordinary squamous metaplasia (sm), atypical immature squamous metaplasia (aim), high-grade squamous intraepithelial neoplasia (hsil) and papillary squamous cell carcinoma (psc). pim has been suggested to be a subset of condyloma associated with low-risk type human papilloma virus (hpv), however, the etiologic role of hpv and biologic behavior of the d ... | 2001 | 11748359 |
| the genetic events of hpv-immortalized esophageal epithelium cells. | we studied cytogenesis, telomere and telomerase, and c-myc, ras, bcl-2, and p53 genes of cells in the progressive process of immortal epithelial cells from embryonic esophagus induced by human papillomavirus (hpv). the shee cell line, established by us, consist of immortalized epithelial cells from the embryonic esophagus induced by genes e6e7 of hpv type 18. it was in initial malignant transformation when cultivated over 60 passages without co-carcinogens. cells of the 10th, 31st, and 60th pass ... | 2001 | 11605024 |
| absence of human papillomavirus dna in nongenital seborrheic keratosis. | seborrheic keratosis (sk) is a benign epidermal tumor of unknown etiology. because of its wart-like morphology, human papillomavirus (hpv) has been suggested as a possible causative agent. viral involvement, however, has not been confirmed yet despite extensive research. the aim of this study was to evaluate the presence of hpv 6/11, 31, 33 dna in nongenital sk. we analyzed 40 biopsy specimens taken from patients with nongenital sk using in situ polymerase chain reaction (pcr) and pcr with tissu ... | 2001 | 11641533 |
| suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix-induced apoptosis. | little is known about the fate of normal human mammary epithelial cells (hmecs) that lose p53 function in the context of extracellular matrix (ecm)-derived growth and polarity signals. retrovirally mediated expression of human papillomavirus type 16 (hpv-16) e6 and antisense oligodeoxynucleotides (odns) were used to suppress p53 function in hmecs as a model of early breast cancer. p53+ hmec vector controls grew exponentially in reconstituted ecm (recm) until day 6 and then underwent growth arres ... | 2001 | 11673474 |
| oral contraceptives and cancer: an update. | most up-to-date information on oral contraceptives (ocs) and breast cancer risk comes from a collaborative re-analysis of individual data on 53297 cases and 100239 controls. it is now established that there is a moderately increased breast cancer risk among current oc users, which tends to level off in the few years after stopping use. with regard to cervical cancer, oc use has been found to be associated with increased risk in human papilloma virus-positive women. with reference to the well kno ... | 2001 | 11676302 |
| human papillomavirus infection among egyptian females with cervical carcinoma: relationship to spontaneous apoptosis and tnf-alpha. | this study was designed to detect hpv type-16 in cervical carcinoma (cc) tissue specimens. the results were correlated with clinicopathological parameters of the carcinoma, with spontaneous apoptosis and with immunoreactivity to tnf-alpha antibodies. | 2001 | 11676979 |
| gene transfer using human papillomavirus pseudovirions varies according to virus genotype and requires cell surface heparan sulfate. | artificial viruses consisting of dna plasmid packaged in vitro into virus-like particles (vlps) are new vehicles for gene transfer. we therefore investigated the ability of nine human papillomavirus (hpv) vlps to interact with heterologous dna and transfer genes. hpv 16, 18, 31, 33, 39, 45, 58, 59, and 68 vlps were able to bind heterologous dna and to transfer genes into cos-7 cells. inhibition of gene transfer by preincubation of the pseudovirions with heparin confirmed that heparan sulfate on ... | 2001 | 11682199 |
| highly differentiated keratinizing squamous cell cancer of the cervix: a rare, locally aggressive tumor not associated with human papillomavirus or squamous intraepithelial lesions. | the purpose of this study is to report an unusual variant of cervical squamous cell carcinoma, not associated with either human papillomavirus infection or antecedent squamous intraepithelial lesions. five women had a diagnosis of invasive cervical cancer discovered at hysterectomy performed for prolapse (two cases), leiomyoma (one case), or a vaginal fistula (two cases). the women ranged in age from 47 to 78 years (mean 59 years). four of the five had a history of normal papanicolaou (pap) smea ... | 2001 | 11688467 |
| value of morphological criteria in diagnosing cervical hpv lesions confirmed by in situ hybridization and hybrid capture assay. | the present study evaluated the value of morphological criteria (binucleation, multinucleation, koilocytosis, spindle koilocytes, abnormal mitosis and dyskeratosis) in the diagnosis of cervical human papillomavirus (hpv) lesions confirmed by in situ hybridization (ish) and hybrid capture (hc) assay. colposcopic punch biopsies from a series of 138 women with abnormal pap smears were examined on light microscopy and in situ hybridization (dako widespectrum cocktail probe) for hpv-induced morpholog ... | 2001 | 11700889 |
| warty carcinoma of the anus: a variant of squamous cell carcinoma associated with anal intraepithelial neoplasia and human papillomavirus infection. | warty carcinoma (wc) is a rare variant of squamous cell carcinoma primarily described in the vulva in younger women and classically associated with human papillomavirus (hpv) infection. the gross findings are similar to those of verrucous carcinoma with large, exophytic tumors with a papillomatous surface. microscopically, the tumor is papillated and contains fibrovascular cores covered by hyperkeratotic epithelium showing presence of koilocytes. we report a case of anal squamous cell carcinoma ... | 2001 | 11701985 |
| is there a role for human papillomavirus testing in clinical practice? | 2001 | 11704159 | |
| human papillomavirus genotypes in rural mozambique. | we studied the genotype distribution of cervical human papillomavirus (hpv) infections in an age-stratified sample of 262 women in mozambique using the pgmyo9-pgmy11 primer system in a reverse line-blot strip-based assay with high sensitivity in type-specific amplification. despite the low precision of the estimates, we found that hpv-16 was not the dominant type. instead, hpv 35 was the most commonly identified genotype among hpv-positive women (16/96 [17%]) and women with cervical neoplasia (7 ... | 2001 | 11705494 |
| natural history of cervical human papillomavirus. | 2001 | 11705599 | |
| interaction of human papillomavirus type 11 e7 protein with tap-1 results in the reduction of atp-dependent peptide transport. | human papillomaviruses (hpvs) cause benign and malignant epithelial tumors of the respiratory and genital mucosa. we previously reported that recurrent respiratory papillomas caused by hpv 6/11 express low levels of antibody-detectable tap-1, the protein that transports peptides into the endoplasmic reticulum for assembly and presentation by mhc class i, and that the extent of tap-1 immunostaining is inversely related to the frequency of disease recurrence. we have now determined a mechanism for ... | 2001 | 11580231 |
| chromosome 6p21.2, 18q21.2 and human papilloma virus (hpv) dna can predict prognosis of cervical cancer after radiotherapy. | loss of heterozygosity (loh) is one of the most important mechanisms for inactivation of tumor-suppressor genes. studies of loh in patients with cervical carcinoma have reported a high frequency of loh on 3p21.3, 6p21.2, 17p13.1, and 18q21.2. our study explored whether p53 status, human papilloma virus (hpv), and loh on chromosome 3p21.3, 6p21.2, 17p13.1, and 18q21.2 are associated with treatment outcome in 65 patients with cervical cancer after radiotherapy. tumors and normal dna were analyzed ... | 2001 | 11582581 |
| microsatellite instability, expression of hmsh2 and hmlh1 and hpv infection in cervical cancer and their clinico-pathological association. | infection with specific genotypes of human papillomavirus (hpv) has been strongly implicated in cervical carcinogenesis. however, hpv infection alone is insufficient for malignant transformation of the cervical epithelium. an alteration of microsatellite repeats is the result of slippage owing to strand misalignment during dna replication and is referred to as microsatellite instability (msi). these defects in dna repair pathways have been related to human carcinogenesis; however, the role of ms ... | 2001 | 11586036 |
| human papillomavirus pcr direct sequencing study of cervical precancerous lesions in quebec children. | 2001 | 11588297 | |
| human papilloma virus 16 e7 oncogene does not cooperate with ret/ptc 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice. | we have previously reported that the thyroid-targeted expression of the ret/ptc3 oncogene (tg-ret/ptc3) in transgenic mice induces follicular hyperplasia with papillary architecture, resulting in a modest increase of the thyroid gland volume, followed by the appearance of papillary carcinomas in approximately 1-year-old animals. in order to analyze the genetic alterations that may cooperate with ret/ptc3 in the development or progression of thyroid tumors, we interbred tg-ret/ptc3 mice with tg-e ... | 2001 | 11589306 |
| neutralization of human papillomavirus type 11 (hpv-11) by serum from women vaccinated with yeast-derived hpv-11 l1 virus-like particles: correlation with competitive radioimmunoassay titer. | neutralization of human papillomavirus type 11 (hpv-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like particles (vlps). theoretically, neutralizing antibodies could protect women from hpv infection. the immunogenicity of a yeast-derived hpv-11 l1 vlp vaccine was tested in women. serum specimens were evaluated for hpv-11 titer by competitive radioimmunoassay (cria) and for neutralization by use of the athymic mouse xenograft system. analysis of ... | 2001 | 11598842 |
| centrosome abnormalities, genomic instability and carcinogenic progression. | centrosome abnormalities are a frequent finding in various malignant tumors. since centrosomes form the poles of the mitotic spindle, these abnormalities have been implicated in chromosome missegregation and the generation of aneuploid cells which is commonly found in many human neoplasms. it is a matter of debate, however, whether centrosome alterations can drive cells into aneuploidy or simply reflect loss of genomic integrity by other mechanisms. since these two models have fundamentally diff ... | 2001 | 11342187 |
| clinicopathologic features and human papillomavirus dna prevalence of warty and squamous cell carcinoma of the penis. | squamous cell carcinoma (scc) accounts for 95% of penile malignant neoplasms. a subtype of scc, named warty carcinoma (wc), is a morphologically distinct verruciform tumor with features of human papillomavirus (hpv)-related lesions. descriptions of the behavior and histologic features of this tumor are scarce in the literature. the aim of this report is to analyze the clinicopathologic features and hpv deoxyribonucleic acid status in 60 sccs and 11 wcs. the mean patient age was 46.5 +/- 15.9 yea ... | 2001 | 11342782 |
| an evaluation of infectious diseases in cervicovaginal smears from patients with atypical cells of undetermined significance. | despite all studies of infectious disease of the female genital tract, there have been a few studies of the many different types of infectious organisms on pap smears that contain abnormal cells. the purpose of this study is to evaluate the significance of infectious organisms in women with a cytologic diagnosis of atypical squamous cells of undetermined significance (ascus). this study utilizes 398 cervicovaginal smears and concurrent cervical biopsies (test and control cases) obtained from the ... | 2001 | 11347382 |
| conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes. | normal somatic cells terminate their replicative life span through a pathway leading to cellular senescence, which is triggered by activation of p53 and/or prb in response to critically shortened telomere dna. potentially neoplastic cells must first overcome the senescence checkpoint mechanisms and subsequently activate telomerase to propagate indefinitely. although telomerase activation is closely associated with cellular immortality, telomerase alone is not sufficient to warrant tumorigenicity ... | 2001 | 11349961 |
| typing of human papillomavirus by pyrosequencing. | the possibility of using a new bioluminometric dna sequencing technique, called pyrosequencing, for typing of human papillomaviruses (hpv) was investigated. a blinded pyrosequencing test was performed on an hpv test panel of 67 gp5+/gp6+ pcr-derived amplification products. the 67 clinical dna samples were sequenced up to 25 bases and sequences were searched using blast. all of the samples were correctly genotyped by pyrosequencing and the results were unequivocally in accordance with the results ... | 2001 | 11351039 |
| high prevalence of human papillomavirus infection in mexican males: comparative study of penile-urethral swabs and urine samples. | although extensive information has been gathered about the prevalence and determinants of human papillomavirus infection among women, little is known about the prevalence and natural history of this infection among males. | 2001 | 11354266 |
| listeriolysin--a useful cytolysin. | 2001 | 11357827 | |
| colposcopically directed biopsy findings in the young female. | to evaluate the colposcopic findings of cervical alterations in the young sexually active female. | 2001 | 11358705 |
| feedback regulation between orphan nuclear receptor tr2 and human papilloma virus type 16. | the human tr2 orphan receptor (tr2), initially isolated from testis and prostate cdna libraries, is a member of the steroid receptor superfamily. tr2 can regulate several target genes via binding to a consensus response element (aggtca) in direct repeat orientation (aggtcax((n))aggtca, n = 0-6). here we show that tr2 is able to induce the expression of human papilloma virus type 16 (hpv-16) genes via binding to a dr4 response element in the long control region of hpv-16. additionally, one of the ... | 2001 | 11358973 |
| adhesion of cd34+ marrow precursors to human stroma is related to alphasm actin expression by human marrow myofibroblasts. | we have studied the adhesion of human marrow cd34(+) precursors to stromal layer of nontransformed human marrow myofibroblasts (normal stroma) and to different stromal cell lines immortalized by t (pu-34) or t and t (l88/5, l87/4, l2ori-, km-102) oncogenes from simian virus 40 and e6, e7 oncogenes from human papilloma virus 16 (hs-27a, hs-23). flow cytometry and western blotting studies showed that cells from all lines were stromal myofibroblasts similar to normal stroma. using an original metho ... | 2001 | 11359676 |
| enhancement of p53-dependent gene activation by the transcriptional coactivator zac1. | a recently discovered potential tumor suppressor protein, zac1, was previously shown to promote cell cycle arrest and apoptosis, and to act as a positive or negative transcriptional cofactor for nuclear receptors. since these activities are common to zac1 and p53, we tested for a functional interaction between these two proteins by investigating possible effects of zac1 on the transcriptional activator function of p53. zac1 specifically enhanced the activity of p53-responsive promoters in cells ... | 2001 | 11360197 |
| hpv co-factors related to the development of cervical cancer: results from a population-based study in costa rica. | we examined factors associated with high-grade squamous intraepithelial lesions (hsil) and cervical cancer among human papillomavirus (hpv)-infected women in a prevalent case-control study conducted within a population-based cohort of 10 077 women in costa rica. we compared 146 women with hpv-positive hsil or cancer (hsil/ca) against 843 hpv-positive women without evidence of hsil/ca. subjects completed a risk factor questionnaire. we evaluated the associations between exposures and hsil/ca amon ... | 2001 | 11336474 |
| staurosporine-induced apoptosis of hpv positive and negative human cervical cancer cells from different points in the cell cycle. | in the present study, we compare the sensitivity of caski and hela cells (hpv positive, wild-type p53) and c33a cells (hpv negative, mutated p53) to a protein kinase inhibitor, the staurosporine (st). we show that st can reversibly arrest the three cervical-derived cell lines, either in g1 or in g2/m. beyond certain st concentrations or/and over 24 h exposure, the cells underwent apoptosis. this process took place in g1 and g2/m for c33a and caski plus hela cell lines, respectively. by using an ... | 2001 | 11319606 |
| control of interferon signaling in human papillomavirus infection. | human papillomaviruses (hpv) infect mucosal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. persistent infection with sexually transmitted oncogenic hpv types represents the major risk factor for the development of cervical cancer. the development of hpv-associated cervical cancer has been closely linked to the expression of the viral oncogenes e6 and e7 in the tumor cells. the major viral oncoproteins, e6 and e7, target the cellular tumor suppr ... | 2001 | 11325599 |
| physical interaction of human papillomavirus virus-like particles with immune cells. | human papillomavirus virus-like particles (hpv vlp) and chimeric vlp are immunogens that are able to elicit potent anti-viral/tumor b and t cell responses. to investigate the immunogenicity of vlp, we determined which cells of the immune system are able to bind hpv-16 vlp. vlp were found to bind very well to human and mouse immune cells that expressed markers of antigen-presenting cells (apc) such as mhc class ii, cd80 and cd86, including dendritic cells, macrophages and b cells. mab blocking st ... | 2001 | 11312251 |
| regression of canine oral papillomas is associated with infiltration of cd4+ and cd8+ lymphocytes. | canine oral papillomavirus (copv) infection is used in vaccine development against mucosal papillomaviruses. the predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant cd4+ and cd8+ cells, with cd4+ cells being most numerous. comparison of these findings, and those o ... | 2001 | 11312659 |
| papillomavirus-like particles induce acute activation of dendritic cells. | the role of viral structural proteins in the initiation of adaptive immune responses is poorly understood. to address this issue, we focused on the effect of noninfectious papillomavirus-like particles (vlps) on dendritic cell (dc) activation. we found that murine bone marrow-derived dendritic cells (bmdcs) effectively bound and rapidly internalized bovine papillomavirus vlps: exposure to fully assembled vlps of bovine papillomavirus, human papillomavirus (hpv)16 or hpv18, but not to predominate ... | 2001 | 11313370 |
| improving vaccine potency through intercellular spreading and enhanced mhc class i presentation of antigen. | the potency of naked dna vaccines is limited by their inability to amplify and spread in vivo. vp22, a hsv-1 protein, has demonstrated the remarkable property of intercellular transport and may thus provide a unique approach for enhancing vaccine potency. therefore, we created a novel fusion of vp22 with a model ag, human papillomavirus type 16 e7, in a dna vaccine that generated enhanced spreading and mhc class i presentation of ag: these properties led to a dramatic increase in the number of e ... | 2001 | 11313416 |
| enhancement of suicidal dna vaccine potency by linking mycobacterium tuberculosis heat shock protein 70 to an antigen. | naked dna vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. there are particular concerns with dna vaccines however, such as potential integration into the host genome, cell transformation, and limited potency. the usage of dna-based alphaviral rna replicons (suicidal dna vectors) may alleviate the concerns of integration or transformation since suicidal dna vectors eventually cause lysis of transfected cells ... | 2001 | 11313814 |
| cervical cancer: epidemiology, prevention and the role of human papillomavirus infection. | organized screening has contributed to a decline in cervical cancer incidence and mortality over the past 50 years. however, women in developing countries are yet to profit extensively from the benefits of screening programs, and recent trends show a resurgence of the disease in developed countries. the past 2 decades have witnessed substantial progress in our understanding of the natural history of cervical cancer and in major treatment advances. human papillomavirus (hpv) infection is now reco ... | 2001 | 11314432 |
| [value of estrogen and progesterone receptors in the management of intraepithelial squamous lesions of low grade]. | the objective of this study was to know the prognostic value of estrogen receptors and progesterone receptors positives (er+, pr+) in the management of low grade squamous intraepithelial lesions [(lgsil), human papillomavirus (hpv) and cervical intraepithelial neoplasia grade 1 (cin 1) and menopausal status]. | 2001 | 11268728 |
| [molecular changes in epidermoid carcinoma of the oropharynx]. | in most of the studies about molecular alterations in squamous cell carcinomas of the head and neck there is not distinction between the different subsites of this area. the objective of this study is to describe the molecular alterations in squamous cell carcinomas of the oropharynx. twenty-nine oropharyngeal carcinomas, with a minimum follow-up of 36 months, were studied. the molecular alterations analyzed were: the amplification of 11q13 region (in the 29 cases), and the myc and erbb1 oncogen ... | 2001 | 11269875 |
| physical state of hpv16 and chromosomal mapping of the integrated form in cervical carcinomas. | using a procedure based on restriction enzyme cleavage, self-ligation, and inverse polymerase chain reaction (rlipcr), the authors investigated 18 cervical intraepithelial neoplasia iii (cin iii) cases and 37 invasive squamous carcinomas for integration of human papillomavirus type 16 (hpv16). all eighteen cin iii cases (severe dysplasia or high-grade squamous intraepithelial lesion) were found to harbor episomal hpv, but one of the samples contained mixed episomal and integrated forms. seventee ... | 2001 | 11277395 |
| dual growth arrest pathways in astrocytes and astrocytic tumors in response to raf-1 activation. | normal human fibroblasts have been shown to undergo a p16(ink4a)-associated senescence-like growth arrest in response to sustained activation of the ras/raf/mek/erk pathway. we noted a similar p16(ink4a)-associated, senescence-like arrest in normal human astrocytes in response to expression of a conditional form of raf-1. while hpv16 e7-mediated functional inactivation of the p16(ink4a)/prb pathway in astrocytes blocked the p16(ink4a)-associated growth arrest in response to activation of raf-1, ... | 2001 | 11278920 |
| detection of integrated papillomavirus sequences by ligation-mediated pcr (dips-pcr) and molecular characterization in cervical cancer cells. | human papillomavirus (hpv) genomes usually persist as episomal molecules in hpv associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in hpv-related cancers cells. this suggests that malignant conversion of hpv-infected epithelia is linked to recombination of cellular and viral sequences. due to technical limitations, precise sequence information on viral-cellular junctions were obtained only for few cell lines and primary lesions. in order to facilita ... | 2001 | 11279600 |
| investigation of human papillomavirus in transitional cell carcinomas of the urinary bladder in south africa. | to investigate the prevalence of human papillomavirus in transitional cell carcinoma of the urinary bladder in south africa. | 2001 | 11280602 |
| the effect of stopping smoking on cervical langerhans' cells and lymphocytes. | to investigate the effects of stopping smoking on cervical langerhans' cells and lymphocytes. | 2001 | 11281472 |
| detection of high-risk subtypes of human papillomavirus in cervical swabs: routine use of the digene hybrid capture assay and polymerase chain reaction analysis. | human papillomaviruses (hpvs) are major causative agents in the pathogenesis of cervical cancer, and more than twenty types are associated with its development. with the introduction of liquid-based preparation systems, it is envisaged that large-scale hpv testing will be established in the near future. preliminary studies demonstrate the accessibility of these samples for dna testing using both the digene hybrid capture assay (dhca) and polymerase chain reaction (pcr) techniques. this study aim ... | 2001 | 11284220 |
| significance of high-risk human papillomavirus detection by polymerase chain reaction in primary cervical cancer screening. | the purposes of this study were to evaluate the incidence of high-risk human papillomavirus (hpv) infection by polymerase chain reaction (pcr) and to assess its diagnostic usefulness in primary cervical screening. pcr testing for hpv type 16, 18, 31 and 33 was performed on 1305 specimens obtained during routine cervical cancer screening. we analysed the concurrent cervical smears and biopsy, and correlated them with the hpv infection status. we also evaluated histologically-proven cases with asc ... | 2001 | 11284951 |
| herpesvirus infection of seborrheic keratoses. | we present three examples of patients with seborrheic keratoses complicated by necrotizing herpesvirus infection. two patients had localized cutaneous herpetic infections, and the third patient had a generalized cutaneous herpesvirus infection. two of the lesions were thought to be squamous cell carcinoma. the third was clinically identified as inflamed seborrheic keratosis. herpesvirus infection was not clinically suspected in two of the patients. the histologic changes were similar in all case ... | 2001 | 11285412 |
| will new human papillomavirus diagnostics improve cervical cancer control efforts? | with the causal link between specific types of human papillomavirus (hpv) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering hpv testing in screening, triage, and posttreatment management. many unanswered questions remain, but a growing body of evidence supports a role for hpv testing in cervical cancer prevention programs. already, clinical centers that serve thousands of women in europe and the united states have incorporated hpv dna tests ... | 2001 | 11286660 |
| human papilloma virus (hpv) and p53 immunostaining in advanced tonsillar carcinoma--relation to radiotherapy response and survival. | human papilloma virus (hpv), which is frequently present in tonsillar carcinoma seems to be a prognostically favourable factor for patient survival and also for low risk of relapse. since hpv may abrogate the function of wild type p53 and hence influence radiosensitivity we attempted to analyse if hpv and p53 status in tonsillar carcinoma affected tumour response to radiotherapy (rt) and patient survival. | 2001 | 11299799 |
| a murine model for the effects of pelvic radiation and cisplatin chemotherapy on human papillomavirus vaccine efficacy. | therapeutic human papillomavirus (hpv) vaccines for cervical cancer depend on a competent immune system to be effective. however, cancer patients are often found to be immunosuppressed, which could be attributable to prior radiation, chemotherapy, or the tumor burden itself. this study investigated whether pelvic radiation or cisplatin treatment affected the efficacy of an hpv vaccine and how long these effects lasted. mice were given pelvic radiation, 2 gy/day to a total dose of 45 gy, or 5 mg/ ... | 2001 | 11300486 |
| bladder cancer in africa: update. | carcinoma of the bladder is the most prevalent cancer in egypt and in most african countries. at the national cancer institute (nci), cairo, it constitutes 30.3% of all cancers. the median age at diagnosis is 46 years, with a male preponderance of 5:1. whether in egypt or other african countries such as sudan, kenya, uganda, gold coast, and senegal, it is mostly of the squamous cell type, and arises in a background of schistosomiasis or bilharziasis. tumors are usually advanced at the time of pr ... | 2001 | 11301380 |
| cervical cancer in latin america. | cervical cancer is a common cause of morbidity and mortality in developing countries. in latin america, the incidence rates in several cities are among the highest worldwide, probably due to a high frequency of risk factors and/or a low screening coverage for cervical cancer. epidemiologic studies conducted in latin america (and some in the caribbean), that have investigated the main risk factors for the disease, as well as screening coverage by papanicolaou (pap) smear, were reviewed. the preva ... | 2001 | 11301382 |
| acquired immunodeficiency syndrome-associated cancers in sub-saharan africa. | sub-saharan africa is considered home to more than 60% of all human immunodeficiency virus (hiv) infected cases, with an estimated adult prevalence of 8.0%. it is stated that this region has contributed more than 90% of childhood deaths related to hiv infection and about 93% of childhood acquired immunodeficiency syndrome (aids)-related deaths. although no country in africa is spared of the infection, the bulk is seen in east and south africa, with the highest recorded rates of 20% to 50% in zim ... | 2001 | 11301383 |
| human papillomavirus testing and the management of women with mildly abnormal cervical smears: an observational study. | 2001 | 11302900 | |
| a high frequency of allelic loss in oral verrucous lesions may explain malignant risk. | verrucous carcinoma (vc), a variant of squamous cell carcinoma (scc), is distinct from scc in morphology and behavior. the underlying genetic changes involved in the development of vc and its precursor verrucous hyperplasia (vh) are unknown. this study determined whether chromosomal regions frequently lost during the development of scc are also lost in the vh/vc variant. twenty-five vh and 17 vc were analyzed for loss of heterozygosity (loh) at 19 loci on 7 chromosome arms using microsatellite a ... | 2001 | 11304582 |
| the association of human papillomavirus 16/18 infection with lung cancer among nonsmoking taiwanese women. | lung cancer is the leading cause of cancer death in taiwanese women since 1982. high lung cancer mortality ratio of male:female in taiwan (2:1) was observed, although less than 10% of female lung cancer patients are smokers. until now, the etiological factor remains unknown. we hypothesize that high-risk human papillomavirus (hpv) 16/18 may be associated with lung cancer development based on high prevalence of p53 negative immunostainings in female lung tumors compared with that of male lung tum ... | 2001 | 11306446 |
| the cytokines tumor necrosis factor-alpha (tnf-alpha ) and tnf-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 e7 oncoprotein. | keratinocytes are the natural target cells for infection by human papillomaviruses (hpvs), most of which cause benign epithelial hyperplasias (warts). however, a subset of papillomaviruses, the "high risk" hpvs, cause lesions that can progress to carcinomas. inflammatory mediators such as tumor necrosis factor-alpha (tnf-alpha) and tnf-related apoptosis-inducing ligand (trail) are produced by cells in response to a viral infection. to determine the effects of tnf-alpha and trail on keratinocytes ... | 2001 | 11306566 |
| clinical and prognostic significance of human papillomavirus in a chinese population of cervical cancers. | to investigate the clinical and prognostic significance of human papillomavirus (hpv) in a chinese population of cervical cancers. | 2001 | 11306910 |
| aberrant expression of cyclin d1 is associated with poor prognosis in early stage cervical cancer of the uterus. | many investigators have studied the expression of g1 phase regulatory protein in uterine cervical cancer. however, it is unclear which step of the genetic expression participates in cyclin d1 expression and what its prognostic meaning is. the aims of this study were to evaluate the regulatory level of cyclin d1 expression and the relationship between the expression of cyclin d1 and its inhibitor, p21waf1/cip1, and to evaluate their impact on the prognosis of early stage cervical cancer. | 2001 | 11371120 |
| human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in anyang area of china. | to investigate the potential role of human papillomavirus (hpv) infection in the pathogenesis of esophageal carcinomas in the anyang area of china, we have evaluated specimens collected by balloon cytology examination from volunteers in two regions with significantly different incidences of esophageal carcinoma. 138 donors were from a village in a county with an esophageal carcinoma (ec) age-adjusted mortality rate of 132x10(5), the remaining 68 were resident in a second village from another cou ... | 2001 | 11375901 |
| pathogenesis of esophageal squamous cell carcinoma with lymphoid stroma. | lymphocyte infiltration in esophageal cancer, especially when beneath intraepithelial carcinoma, is frequently seen. however, cases of esophageal cancer with a dense stromal infiltration of lymphocytes are rare and the pathogenesis of such cases has yet to be clearly demonstrated. the objective of this study is to clarify its pathogenesis. | 2001 | 11379332 |
| histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. | recent studies of the p53 homologue p63 indicate that this gene is preferentially expressed in basal and immature cervical squamous epithelium. this study correlated p63 expression with morphologic phenotype and human papillomavirus (hpv) type in a wide range of cervical neoplasms. two hundred fifty cases of cervical carcinoma, including squamous cell carcinoma (scca; n = 178), adenocarcinoma (adca; n = 28), adenosquamous carcinoma (asca; n = 8), neuroendocrine carcinoma (neca; n = 15), and othe ... | 2001 | 11381365 |
| women's knowledge of pap smears, risk factors for cervical cancer, and cervical cancer. | to review the literature on women's knowledge of pap smears, risk factors for cervical cancer, and cervical cancer. | 2001 | 11383953 |
| [type i and iv collagenases and their endogenous regulators in immortalized and transformed fibroblasts]. | to elucidate the role of matrix metalloproteinases (mmp) in carcinogenesis, the expression of collagenases of types i (mmp-i) and iv (mmp-2 and mmp-9) as well as the behaviour of urokinase-like plasminogen activator (upa) and of tissue mmp inhibitors (timp) in immortalized (if) and transformed (tf) fibroblasts were investigated. the study was carried out using embryo rat fibroblasts, sequentially immortalized with the lt gene of human papilloma virus and transformed with the e7 gene of human pap ... | 2001 | 11386000 |
| much higher risk of premalignant and malignant cervical diseases in younger women positive for hpv16 than in older women positive for hpv16. | human papillomavirus (hpv), particularly hpv16, is strongly associated with premalignant lesions of the uterine cervix and cervical cancer. however, hpv infection is a common sexually transmitted disease and only a few women develop cervical cancer. although the presence of hpv and abnormal cytology are independent risk factors for cervical diseases, implementing both tests on every woman is argued not to be recommended mainly in terms of cost-effectiveness. during a 20-month period between octo ... | 2001 | 11386424 |
| cost-effectiveness of monolayers and human papillomavirus testing compared to that of conventional papanicolaou smears for cervical cancer screening: protocol of the study of the french society of clinical cytology. | the french society of clinical cytology is conducting a study to compare the cost-effectiveness of monolayers and human papillomavirus (hpv) testing with that of conventional papanicolaou (pap) smears for cervical cancer screening. the protocol of this study is presented. it includes 3,000 women who will be evaluated by the three methods (conventional pap smears, or monolayers with or without hpv testing) and by the reference method: colposcopy followed, in cases with abnormalities, by cervical ... | 2001 | 11391824 |
| prevalence of human papillomavirus infection among prostitutes in calcutta. | we investigated the presence of human papilloma virus (hpv) 16/18 and herpes simplex virus-1,-2 (hsv-1,-2) infections in buccal mucosal cells of prostitutes of calcutta, india, by in situ dna hybridization and immunocytochemical technique. in some of them, we also examined the prevalence of viral infections in uterine cervical cells. the women were also tested for venereal disease research laboratory antigen (vdrl) positivity. oral infections with hsv-1, -2 and hpv 16/18 were detected in 24.6%, ... | 2001 | 11394709 |
| acceptability of a human papillomavirus (hpv) trial vaccine among mothers of adolescents in cuernavaca, mexico. | a scenario that must be considered when testing prophylactic human papillomavirus (hpv) vaccines in teenagers is the parents' acceptability of their daughters' participation in the study. | 2001 | 11395192 |
| pre-clinical safety and efficacy of ta-cin, a recombinant hpv16 l2e6e7 fusion protein vaccine, in homologous and heterologous prime-boost regimens. | human papillomavirus (hpv) e6 and e7 oncoproteins are attractive targets for t-cell-based immunotherapy of cervical intraepithelial neoplasia (cin) and cancer. a newly designed vaccine, comprising the hpv16 l2, e6 and e7 as a single fusion protein (ta-cin), was shown to elicit hpv16-specific ctl, t-helper cells and antibodies in a pre-clinical mouse model. these immune responses effectively prevented outgrowth of hpv16-positive tumour cells in a prophylactic setting as well as in a minimal resid ... | 2001 | 11395199 |
| human papillomavirus as a risk factor for oral squamous cell carcinoma: a meta-analysis, 1982-1997. | human papillomavirus (hpv) infection is a significant risk factor for uterine cervical carcinoma. however, the role of hpv infection in oral squamous cell carcinoma (oscc) is less well defined. to determine the significance of the relationship of this virus in the progressive development of oral cancer, we estimated the risk of hpv detection in normal oral mucosa, precancerous oral tissue, and oral carcinoma using meta-analysis. | 2001 | 11402272 |
| efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in hiv-infected persons. | treatment options for anogenital warts in patients with hiv-1 are unsatisfactory because they fail to eradicate latent human papillomavirus. | 2001 | 11403192 |
| a simple and efficient method for the monitoring of antigen-specific t cell responses using peptide pool arrays in a modified elispot assay. | in this study, we describe a simple and efficient method for both the monitoring of antigen-specific cd4 and cd8 t cell responses as well as the identification of novel cd4 and cd8 t cell epitopes using a modified elispot assay and pools of 20mer peptides. we have demonstrated that pools containing as many as 64 20mer peptides may be used to screen for cd4 and cd8 t cell responses to hpv16 l1, e1, and e7 in mice. using arrays of pools of overlapping 20mer peptides, we have identified novel cd4 a ... | 2001 | 11406153 |
| tetrasomy is induced by human papillomavirus type 18 e7 gene expression in keratinocyte raft cultures. | we have demonstrated previously that oncogenic human papillomaviruses (hpvs) induce basal cell tetrasomy in low-grade squamous intraepithelial lesions of the cervix. to identify hpv genes and growth conditions involved in this process, we analyzed: (a) organotypic raft cultures of primary human keratinocytes transfected with whole hpv-18 genomes; and (b) organotypic raft cultures acutely infected with recombinant retroviruses expressing the hpv-18 e6, e7, or e6/e7 genes from the differentiation- ... | 2001 | 11406563 |
| risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. | low-grade squamous intraepithelial lesions (lsils) have been described as a benign cytological consequence of active human papillomavirus (hpv) replication. several studies have reported that certain behavioral and biological risks exist for lsil, suggesting that hpv alone is not sufficient for the development of lsil. however, because most of these studies have been cross-sectional, it is not known whether behavioral and biological risks are simply risks for hpv infection itself. | 2001 | 11410098 |
| natural history of cervical human papillomavirus infections. | 2001 | 11410184 | |
| biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. | high-risk human papillomaviruses (hpvs) have been proposed to be associated with a subset of head and neck cancers (hnsccs). however, clear biological evidence linking hpv-mediated oncogenesis to the development of hnscc is hardly available. an important biological mechanism underlying hpv-mediated carcinogenesis is the inactivation of p53 by the hpv e6 oncoprotein. in the present study we investigated this biological relationship between hpv and hnscc. in total 84 hnscc tumors were analyzed for ... | 2001 | 11410871 |
| human papillomavirus infection, risk for subsequent development of cervical neoplasia and associated population attributable fraction. | human papillomavirus (hpv) is the major cause of cervical neoplasia but estimates of the population attributable fraction (par%), of hpv vary. par% has not been derived from longitudinal studies although assessment of hpv exposure prior to the neoplasia diagnosis should increase validity of such estimates. | 2001 | 11418359 |
| both e6 and e7 oncoproteins of human papillomavirus 16 inhibit il-18-induced ifn-gamma production in human peripheral blood mononuclear and nk cells. | cervical carcinoma is the predominant cancer among malignancies in women throughout the world, and human papillomavirus (hpv) 16 is the most common agent linked to human cervical carcinoma. the present study was performed to investigate the mechanisms of immune escape in hpv-induced cervical cancer cells. the presence of hpv oncoproteins e6 and e7 in the extracellular fluids of hpv-containing cervical cancer cell lines siha and caski was demonstrated by elisa. the effect of hpv 16 oncoproteins e ... | 2001 | 11418688 |
| genital squamous cell carcinoma in men treated by photochemotherapy. a cancer registry-based study from 1978 to 1998. | one single report from the u.s. 16-centre-trial indicated that psoralen and ultraviolet a radiation (puva) therapy may induce an increased risk of genital tumours in men, and protection of the genital area is, therefore, recommended. | 2001 | 11422042 |
| epidemiology of aids-related tumours in developed and developing countries. | aids-associated illnesses include kaposi's sarcoma (ks), non-hodgkin's lymphoma (nhl), and, since 1993, invasive cervical cancer (icc). between 1988 and 1998, among aids cases reported in western europe, 9.6% had ks and 3.9% had nhl as aids-defining illnesses. between 1988 and 1998, the frequency of ks decreased from 13.4 to 6.4%, while nhl increased from 3.8 to 5.3%. estimates of the relative risk (rr) of neoplasms in hiv-seropositive populations came from population-based cancer and aids regis ... | 2001 | 11423251 |
| human papillomavirus in conjunctival papilloma. | to examine conjunctival papillomas for the presence of human papillomavirus (hpv) and koilocytosis. | 2001 | 11423448 |
| high prevalence of oncogenic human papillomavirus in the genital tract of women with human immunodeficiency virus. | the goal of this study was to determine the prevalence of human papillomavirus (hpv) and squamous intraepithelial lesions (sils) in women infected with human immunodeficiency virus (hiv) in mexico. | 2001 | 11426958 |
| synthetic peptides induce a cytotoxic response against human papillomavirus type-18. | over 90% of cervical carcinomas express human papillomavirus (hpv) e6 and e7 proteins. these unique antigens are ideal targets for the development of cytotoxic t-lymphocytes (ctl) for antitumor immunotherapy. in this study we identify peptides from hpv-18 e6 and e7 proteins that bind to hla class i molecules. we further show that these peptides are able to induce peptide-specific ctl from an hla-a2-positive (+) peripheral blood donor in vitro. | 2001 | 11426965 |
| negative predictive value of human papillomavirus test following conization of the cervix uteri. | the goal of this study was to determine/evaluate the negative predictive value of human papillomavirus (hpv) testing following conization of cervix uteri. | 2001 | 11426982 |
| policy analysis of cervical cancer screening strategies in low-resource settings: clinical benefits and cost-effectiveness. | cervical cancer is a leading cause of cancer-related death among women in developing countries. in such low-resource settings, cytology-based screening is difficult to implement, and less complex strategies may offer additional options. | 2001 | 11427139 |
| androgen induces differentiation of a human papillomavirus 16 e6/e7 immortalized prostate epithelial cell line. | androgen signaling is crucial for the growth and development, as well as for tumorigenesis of the prostate. however, many of the prostate epithelial cell lines developed previously, either normal or tumorigenic, do not express androgen receptor (ar) or respond to androgen. in order to advance our understanding on how androgen signaling regulates the growth and the differentiation status, and affects tumorigenicity of the epithelial cell, we performed experiments on hpr-1, a prostate cell line re ... | 2001 | 11431162 |
| formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. | the formation of human malignant gliomas is thought to involve the accumulation of multiple genetic alterations. to define the function of specific alterations in glioma formation, we serially introduced genetic alterations functionally equivalent to those noted in human malignant gliomas into normal human astrocytes (nhas). we then monitored the ability of each of these alterations to contribute to the growth of otherwise genetically stable nhas into intracranial malignant gliomas. using this m ... | 2001 | 11431323 |
| low serum and red blood cell folate are moderately, but nonsignificantly associated with increased risk of invasive cervical cancer in u.s. women. | previous observational epidemiologic studies of folate and cervical cancer, as well as folate supplementation trials for cervical dysplasia, have produced mixed results. we examined the relationship between serum and rbc folate and incident invasive cervical cancer in a large, multicenter, community-based case-control study. detailed in-person interviews were conducted, and blood was drawn at least 6 mo after completion of cancer treatment from 51% of cases and 68% of controls who were interview ... | 2001 | 11435527 |
| characterization of adriamycin-induced g2 arrest and its abrogation by caffeine in fl-amnion cells with or without p53. | we investigated the effect of adriamycin on fl-amnion (fl) cells. after treatment with the drug, the cells arrested at g2, but we did not detect an increase in the p21 levels. we established a p53-deficient derivative of these cells, in which g2 arrest also occurred after treatment with adriamycin, suggesting that the arrest we observed in these cells is independent of the p53 pathway. low doses of adriamycin (100-200 ng/ml) induced g2 arrest, while late s-phase arrest was observed at high doses ... | 2001 | 11120603 |
| in vitro models to study cellular differentiation and function in human prostate cancers. | in vitro models to study cellular differentiation and function in human prostate cancers. to augment the currently available models of human prostate cancer in vitro, we have established extended life-span epithelial cultures from biopsies of well-differentiated prostate cancers. the genetic identity of the target cells was assessed by allelotyping, using microsatellites located on chromosome 8p, and microdissection of tissues and primary cell cultures. cells with an extended life span (pxe6) we ... | 2001 | 11121225 |
| oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 e2 and e7 proteins. | human papillomavirus (hpv) type 16 infects the genital tract and is generally acknowledged to be a causative agent of cervical cancer. hpv infection alone is not sufficient to induce cervical cancer and other factors such as steroid hormones are thought to play a role in the establishment and/or progression of this disease. the hpv-16 e2 protein is required for virus replication and modulates viral gene expression whereas the hpv-16 e7 protein is required for cell transformation. we and others h ... | 2001 | 11125173 |
| human papillomavirus in the oral cavities of children and adolescents. | the purpose of this pilot study was to determine the frequency of human papillomavirus (hpv) in the oral cavities of children and adolescents and to identify potential risk factors for hpv infection. | 2001 | 11174573 |