Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| imrt for postoperative treatment of gastric cancer: covering large target volumes in the upper abdomen: a comparison of a step-and-shoot and an arc therapy approach. | data from the randomized intergroup trial 116 suggest effectiveness of adjuvant radiochemotherapy in patients with advanced gastric cancer. late toxicity, however, especially with respect to the kidneys, may pose significant longtime problems. intensity-modulated radiotherapy (imrt) may reduce toxicity to organs at risk. to evaluate the relative merits of different imrt approaches, we performed a plan comparison between a step-and-shoot class solution and an ap-pa setup, a conventional box techn ... | 2004 | 15234061 |
| quality specifications in thyroid diseases. | laboratory tests to support the diagnosis and management of thyroid diseases have undergone significant changes with the introduction of highly sensitive assays for thyroid stimulating hormone (tsh) and free t4 and t3 concentrations in plasma. given the importance of these measurements, quality specifications are needed to ensure accurate results. goals for precision and accuracy are available based on known intraindividual and interindividual biological variation. | 2004 | 15234638 |
| role for postoperative radiation therapy in adenoid cystic carcinoma of the head and neck. | clarify the role for postoperative radiation for adenoid cystic carcinoma (acc) of the head and neck as it relates to tumor site, t-stage, and surgical margin status. | 2004 | 15235347 |
| [potentializing of tricyclics and serotoninergics by thyroid hormones in resistant depressive disorders]. | in response to the increase of resistant depressive disorders and in spite of improved treatments, numerous studies were conducted in the last thirty years aiming at assessing the pre-morbid thyroid state of depressed patients resistant to well conducted tricyclic treatments. "minimal" thyroid abnormalities were evidenced as well as central thyroid disorders which may not be detected by peripheral-i.e plasmatic- dosages. regarding the premorbid thyroid status, the hypothesis of subclinical hypot ... | 2004 | 15235525 |
| thyroid hormone-dependent seasonality in american tree sparrows (spizella arborea): effects of gc-1, a thyroid receptor beta-selective agonist, and of iopanoic acid, a deiodinase inhibitor. | to explore the role of th in the control of seasonality [i.e., photoperiodic testicular growth, photorefractoriness, and postnuptial (prebasic) molt] in american tree sparrows (spizella arborea), we performed experiments in which thx males were simultaneously photostimulated and given th replacement therapy. in the first experiment, equimolar concentrations (1x = 1.3 nmol) of t4, t3, or gc-1, an iodine-free trbeta agonist, were administered s.c. daily during the first 21 days of photostimulation ... | 2004 | 15235810 |
| reconstruction of large composite oromandibulomaxillary defects with free vertical rectus abdominis myocutaneous flaps. | large composite oromandibulomaxillary defects resulting from oncologic resection can be challenging to reconstruct with a single flap, and functional outcomes remain anecdotal. the purpose of this study was to evaluate the authors' surgical experience and scientifically analyze and describe the functional outcomes associated with the use of the vertical rectus abdominis myocutaneous flap for reconstruction of these defects. the records of seven patients (mean age, 62 years) who underwent composi ... | 2004 | 14758209 |
| recognition of dna substrates by t4 bacteriophage polynucleotide kinase. | t4 phage polynucleotide kinase (pnk) displays 5'-hydroxyl kinase, 3'-phosphatase and 2',3'-cyclic phosphodiesterase activities. the enzyme phosphorylates the 5' hydroxyl termini of a wide variety of nucleic acid substrates, a behavior studied here through the determination of a series of crystal structures with single-stranded (ss)dna oligonucleotide substrates of various lengths and sequences. in these structures, the 5' ribose hydroxyl is buried in the kinase active site in proper alignment fo ... | 2004 | 14754987 |
| endoscopic vertical partial laryngectomy. | to explain the significant difference between microlaryngoscopy with cordectomy and endoscopic vertical partial laryngectomy (evpl), to describe the efficacy of evpl on t1b and t2 glottic squamous cell carcinoma, and to evaluate evpl with postoperative irradiation in t2 glottic cancer with impaired true vocal cord mobility. | 2004 | 14755197 |
| effects of recombinant growth hormone therapy on thyroid hormone concentrations. | there are numerous, often contradictory reports on the effects of growth hormone (gh) therapy on thyroid function. the aim of this study was to assess the effect of such therapy on serum concentrations of thyroid hormones in gh-deficient children euthyroid prior to the treatment, and to determine the necessity of thyroid hormone administration in these patients. | 2004 | 14756384 |
| relocation or duplication of the helix a sequence of t4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding. | in t4 lysozyme, helix a is located at the amino terminus of the sequence but is associated with the c-terminal domain in the folded structure. to investigate the implications of this arrangement for the folding of the protein, we first created a circularly permuted variant with a new amino terminus at residue 12. in effect, this moves the sequence corresponding to helix a from the n- to the c-terminus of the molecule. the protein crystallized nonisomorphously with the wild type but has a very si ... | 2004 | 14756565 |
| tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on the activity of 5'-deiodinases i and ii in rats. | thyroid hormones play a complex role in the toxicity of polychlorinated dibenzo-p-dioxins and furans and related compounds. we investigated the toxicological significance of 5'-deiodinases i and ii (5'-di and 5'-dii) in the altered thyroid hormone status of tcdd-treated rats. time courses and dose responses were determined for serum thyroxine (t4) and triiodothyronine (t3) levels, for 5'-di activity in thyroid gland, liver and kidney, and for 5'-dii activity in brown adipose tissue (bat). tcdd-t ... | 2004 | 14757317 |
| bioluminescent immunoassay of thyrotropin and thyroxine using obelin as a label. | solid-phase bioluminescent immunoassay of thyroid hormones, human thyrotropin (htsh) and two forms of thyroxine (t4), whose determinations are vitally important for diagnostics of thyroid diseases and the efficiency of treatment, is described. the recombinant obelin, a ca(2+)-regulated photoprotein originally derived from the luminous marine hydroid obelia longissima, is employed as a bioluminescent label. to produce obelin conjugates with anti-htsh, anti-t4 immunoglobulins (igg), and t4, additi ... | 2004 | 14751258 |
| where next with preoperative radiation therapy for rectal cancer? | purpose: the basic question for radiation oncologists is what we hope to achieve from treatments that are adjuvant to surgery: better local (pelvic) control and, hopefully, because of that, fewer metastases. chemotherapy could add to the local effect of irradiation and may also decrease distant metastases directly. selection criteria for individual treatment could enhance the therapeutic index. local control: total mesorectal excision reduces the incidence of local recurrence, but preoperative ( ... | 2004 | 14751533 |
| preoperative staging of gastric adenocarcinoma: comparison of helical ct and endoscopic us. | to compare the performance of helical computed tomography (ct) and endoscopic ultrasonography (us) in the preoperative staging of gastric cancer. | 2004 | 14752188 |
| thoracic pedicle morphometry in vertebrae from scoliotic spines. | a morphometric analysis of thoracic pedicles in vertebrae from scoliotic specimens. | 2004 | 14752344 |
| free hand pedicle screw placement in the thoracic spine: is it safe? | a retrospective study. | 2004 | 14752359 |
| the patterns of relapse in osteosarcoma: the memorial sloan-kettering experience. | with the introduction of intensive high-dose chemotherapy for the treatment of osteosarcoma, changes in the pattern of metastases observed at relapse have been reported. to further investigate this hypothesis, the relapse patterns among groups receiving chemotherapy regimens of variable intensity at memorial sloan-kettering cancer center were analyzed. | 2004 | 14752794 |
| [summary of the practice guideline 'pregnancy and puerperium' from the dutch college of general practitioners]. | during the first trimester of pregnancy, obstetric care concentrates particularly on assessment of gestational age (by history taking or if menstrual history is unclear, ultrasonography) and on the assessment of obstetric or medical risk factors necessitating a referral for specialist care. tracing hereditary conditions in relatives is important as this is a reason for antenatal screening for congenital abnormalities. in comparison to the previous guideline, blood testing in the first trimester ... | 2004 | 14753127 |
| chemical synthesis of selenium-modified oligoribonucleotides and their enzymatic ligation leading to an u6 snrna stem-loop segment. | the derivatization of nucleic acids with selenium is highly promising to facilitate nucleic acids structure determination by x-ray crystallography using the multiwavelength anomalous dispersion (mad) technique. the foundation for such an approach has been laid by huang, egli, and co-workers and was exemplified on small dna duplexes. here, we present a comprehensive study on the preparation of rnas containing 2'-se-methylpyrimidine nucleoside labels. this includes the synthesis of a novel 2'-se-m ... | 2004 | 14746483 |
| reference dose for perchlorate based on thyroid hormone change in pregnant women as the critical effect. | the most relevant data for developing a reference dose (rfd) for perchlorate exposures comes from human epidemiology and clinical studies, supplemented with available and extensive information on experimental animals. specifically, serum t4 decrease is the critical effect of perchlorate, based on a mode-of-action analysis and the evidence provided by the body of rodent studies on perchlorate. however, no t4 decreases have been observed in human populations following perchlorate exposure at non-t ... | 2004 | 14746779 |
| predicting the node-negative mesorectum after preoperative chemoradiation for locally advanced rectal carcinoma. | preoperative chemoradiation therapy (crt) in patients with locally advanced rectal cancer allows for radical surgery with sphincter preservation in many patients. to determine whether patients downsized with preoperative crt may be potential candidates for local excision, we investigated residual disease patterns after neoadjuvant treatment. a retrospective analysis was carried out of patients with t3 or t4 rectal adenocarcinoma who were treated with neoadjuvant crt. clinical and pathologic data ... | 2004 | 14746836 |
| the poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile. | the aim of this study was to determine the chemosensitivity of infiltrating lobular breast carcinoma (ilc) in comparison with infiltrating ductal carcinoma (idc). between 1987 and 1995, 457 patients with invasive t2>3 cm-t4 breast carcinomas were treated with primary chemotherapy (ct), surgery, radiation therapy. clinical response, the possibility of breast preservation, pathological response and survival were evaluated according to the histological type. in order to evaluate the biological diff ... | 2004 | 14746851 |
| characterization of a baculovirus enzyme with rna ligase, polynucleotide 5'-kinase, and polynucleotide 3'-phosphatase activities. | the end-healing and end-sealing steps of the phage t4-induced rna restriction-repair pathway are performed by two separate enzymes, a bifunctional polynucleotide 5'-kinase/3'-phosphatase and an atp-dependent rna ligase. here we show that a single trifunctional baculovirus enzyme, rna ligase 1 (rnl1), catalyzes the identical set of rna repair reactions. three enzymatic activities of baculovirus rnl1 are organized in a modular fashion within a 694-amino acid polypeptide consisting of an autonomous ... | 2004 | 14747466 |
| effects of levothyroxine suppressive therapy on bone mineral density in premenopausal women. | levothyroxine (l-t4) is widely prescribed for treating thyroid disorders, but its effect on bone mineral density (bmd), is being debated. | 2004 | 14748891 |
| distribution of anterior cortical shear strain after a thoracic wedge compression fracture. | vertebral compression fractures (vcfs) are a common clinical problem and may follow trauma or be pathological. osteoporosis increases susceptibility to fracture by reducing bone mass and weakening bone architecture. approximately 2.5 million osteoporotic fractures occur worldwide annually, usually involving the vertebrae, wrist and hip. in the united states 700,000 vcfs occur annually, causing significant morbidity, mortality and economic burden. an initial vcf often leads to subsequent vcfs. th ... | 2004 | 14749196 |
| effects of thyroid hormone on the cardiovascular system. | increased or reduced action of thyroid hormone on certain molecular pathways in the heart and vasculature causes relevant cardiovascular derangements. it is well established that overt hyperthyroidism induces a hyperdynamic cardiovascular state (high cardiac output with low systemic vascular resistance), which is associated with a faster heart rate, enhanced left ventricular (lv) systolic and diastolic function, and increased prevalence of supraventricular tachyarrhythmias - namely, atrial fibri ... | 2004 | 14749496 |
| noninflammatory breast carcinoma with skin involvement. | according to the tnm supplement, only breast carcinoma with macroscopic 'classic' skin changes (e.g., edema, peau d'orange, ulceration) should be placed in the t4 category; the classification of tumors with histologically proven skin involvement but no clinical skin changes or only discreet changes should be based on the size of the tumor (t1-3). to the authors' knowledge, no data supporting these recommendations have been reported to date. | 2004 | 14745862 |
| should decisions on internal mammary lymph node irradiation be based on current lymphoscintigraphy techniques for sentinel lymph node identification? | treatment of internal mammary lymph node (imn) metastases remains controversial because of the difficulty in predicting involvement, potential treatment-related morbidity, and questionable efficacy. lymphoscintigraphy with sentinel lymph node biopsy offers a means to identify occult involvement of imn, allowing appropriate patient selection for imn treatment. | 2004 | 14745867 |
| preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance. report of the 22921 randomised trial conducted by the eortc radiotherapy group. | the european organisation for research and treatment of cancer (eortc) 22921 four-arm randomised trial questioned the value of preoperative chemoradiation (xrt-ct) versus preoperative radiation (xrt) and the value of additional postoperative chemotherapy (ct) versus none in t3-t4 m0 resectable rectal cancer patients. we report on the preoperative toxicity, treatment compliance and early deaths (all deaths up to 30 days after surgery) of the two treatment modalities in patients who were entered i ... | 2004 | 14728936 |
| expression of type ii iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in xenopus laevis. | the thyroid gland synthesizes thyroxine (t4), which passes through the larval tadpole's circulatory system. the enzyme type ii iodothyronine deiodinase (d2) converts thyroxine (t4) to the active hormone 3,5,3'-triiodothyronine (t3) in peripheral tissues. an early response to thyroid hormone (th) in the xenopus laevis tadpole is the stimulation of cell division in cells that line the brain ventricles, the lumen of the spinal cord, and the limb buds. these cells express constitutively high levels ... | 2004 | 14729480 |
| bacteriophage t4 32 protein is required for helicase-dependent leading strand synthesis when the helicase is loaded by the t4 59 helicase-loading protein. | in the bacteriophage t4 dna replication system, t4 gene 59 protein binds preferentially to fork dna and accelerates the loading of the t4 41 helicase. 59 protein also binds the t4 32 single-stranded dna-binding protein that coats the lagging strand template. here we explore the function of the strong affinity between the 32 and 59 proteins at the replication fork. we show that, in contrast to the 59 helicase loader, 32 protein does not bind forked dna more tightly than linear dna. 32 protein dis ... | 2004 | 14729909 |
| recurrent advanced (t3 or t4) head and neck squamous cell carcinoma: is salvage possible? | salvage surgery is often the only curative option for recurrent cancer. in patients whose initial tumor is stage t3 or t4, the primary therapy often makes salvage even more difficult. we therefore analyzed the outcome in patients who were originally treated for t3 or t4 squamous cell carcinoma of the oral cavity, larynx, oropharynx, or hypopharynx and who then had a recurrence and chose to undergo further therapy for cure. | 2004 | 14732765 |
| binding of destabilized betab2-crystallin mutants to alpha-crystallin: the role of a folding intermediate. | age-related changes in protein-protein interactions in the lens play a critical role in the temporal evolution of its optical properties. in the relatively non-regenerating environment of the fiber cells, a critical determinant of these interactions is partial or global unfolding as a consequence of post-translational modifications or chemical damage to individual crystallins. one type of attractive force involves the recognition by alpha-crystallins of modified proteins prone to unfolding and a ... | 2004 | 14761939 |
| [benign childhood epilepsy with centrotemporal spikes: high and low central focus]. | twenty children with benign childhood epilepsy with centrotemporal spikes were studied. anamnesis, neurological exam, "columbia" scale (1993) application and digital electroencephalogram were carried out. the digital electroencephalogram was recorded with electrodes according to 10-20 international system, and a supplementary electrode, between c3 and t3 or c4 and t4-c5 or c6, respectively, at the side with a higher number of spikes. the averaging of the spikes was carried. localization and the ... | 2004 | 14762601 |
| predictive values for aspiration after endoscopic laser resections of malignant tumors of the hypopharynx and larynx. | co2-laser surgery is a relatively new treatment for selected carcinomas of the upper aerodigestive tract. the purpose of our study was to evaluate prospectively the functional results for swallowing after co2-laser resections. | 2004 | 14762878 |
| production and characterization of hemicellulase activities from trichoderma harzianum strain t4. | xylan and mannan are the major constituent groups of hemicellulose in the cell wall of higher plants. the mesophilic fungus trichoderma harzianum strain t4 produces extracellular xylanase and mannanase activities when grown in the presence of oat (avena sativa)-spelt xylan and wheat bran as the carbon sources respectively. after the growth procedure, the crude extracts were submitted to ultrafiltration in an amicon system fitted with a 10 kda-cut-off membrane. mannanase activity was only detecte ... | 2004 | 14763904 |
| change in von willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy. | this study examined whether levothyroxine (l-t4) replacement might affect serum markers of endothelium injury, including von willebrand factor (vwf), factor viii activity and thrombomodulin (tm), during normalization of increased intima-media thickness (imt) in the common carotid artery (cca) in hypothyroid patients after l-t4 replacement therapy. | 2004 | 14763909 |
| first structural investigation of the restriction ribonuclease regb: nmr spectroscopic conditions, 13c/15n double-isotopic labelling and two-dimensional heteronuclear spectra. | the bacteriophage t4 genome-encoded ribonuclease regb is the unique well-defined restriction endoribonuclease. this protein cleaves with an almost absolute specificity its rna substrate in the middle of the ggag tetranucleotide mainly found in the shine-dalgarno sequence (required for the prokaryotic initiation of the translation). this protein has no significant homology to any known ribonuclease and its structure has never been investigated. the extreme toxicity of this ribonuclease prevents t ... | 2004 | 14766312 |
| ultra-fast-track anesthesia in off-pump coronary artery bypass grafting: a prospective audit comparing opioid-based anesthesia vs thoracic epidural-based anesthesia. | to examine the feasibility of immediate extubation after off-pump coronary artery bypass grafting (opcab) using opioid based analgesia or high thoracic epidural analgesia (tea) and compare postoperative analgesia with continuous tea vs patient-controlled analgesia (pca). | 2004 | 14766694 |
| prostate cancer radiotherapy dose response: an update of the fox chase experience. | the effectiveness of increasing radiotherapy dose for men with prostate cancer was evaluated with reference to prognostic groups as defined by pretreatment serum prostate specific antigen (psa), gleason score, t stage and perineural invasion. | 2004 | 14767286 |
| the identification of free-living environmental isolates of amoebae from bulgaria. | a survey was carried out in bulgaria to determine the presence of free-living amoebae (fla) from environmental sources. in 171 (61.1%) of 280 samples, isolates of acanthamoeba with group ii or iii morphology, as well as hartmannella spp. were recovered. five isolates named "6" (artificial lake), ep (lake), g2 (soil), r4* (river) and pk (spring water)--all exhibiting a highly efficient proliferation in axenic cultures--were subsequently cloned and subjected to molecular analyses for identificatio ... | 2004 | 14760525 |
| surgical salvage therapy of anal cancer. | to evaluate the results of salvage resection in the management of persistent or locally recurrent anal canal cancer. | 2004 | 14760771 |
| dual functions of single-stranded dna-binding protein in helicase loading at the bacteriophage t4 dna replication fork. | semi-conservative dna synthesis reactions catalyzed by the bacteriophage t4 dna polymerase holoenzyme are initiated by a strand displacement mechanism requiring gp32, the t4 single-stranded dna (ssdna)-binding protein, to sequester the displaced strand. after initiation, dna helicase acquisition by the nascent replication fork leads to a dramatic increase in the rate and processivity of leading strand dna synthesis. in vitro studies have established that either of two t4-encoded dna helicases, g ... | 2004 | 14871889 |
| dna photosensitization by indoprofen - is dna damage photoinduced by indoprofen or by its photoproducts? | the in vitro photosensitizing activity of indoprofen, a non-steroidal anti-inflammatory drug, toward dna has been studied by gel sequencing experiments using (32)p-end labelled synthetic oligonucleotides in phosphate buffered solution. upon irradiation at [small lambda] > 320 nm, piperidine-sensitive lesions were induced in single- and double-stranded dna, exclusively at the position of guanine bases. in single-stranded dna, all g sites were modified. this pattern of photooxidative damage withou ... | 2004 | 14872241 |
| toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption. | in vitro bioassays are valuable tools for screening environmental samples for the presence of bioactive (e.g., endocrine-disrupting) compounds. they can be used to direct chemical analysis of active compounds in toxicity identification and evaluation (tie) approaches. in the present study, five in vitro bioassays were used to profile toxic potencies in sediments, with emphasis on endocrine disruption. nonpolar total and acid-treated stable extracts of sediments from 15 locations in the rhine meu ... | 2004 | 14768864 |
| endocrine function in thai children infected with human immunodeficiency virus. | most children infected by hiv show manifestations which mimic the clinical features of endocrine dysfunction, such as failure to thrive and hyperpigmentation. our cross-sectional study was designed to assess the endocrine function of thai children infected with hiv and to determine any relationship between disease severity, height and endocrine function. thirty-six prepubertal children infected by hiv, 12 boys and 24 girls, aged 4-12 years (mean +/- sd 7 +/- 2 years), were tested for thyroid fun ... | 2004 | 14960019 |
| structure and mechanism of rna ligase. | t4 rna ligase 2 (rnl2) exemplifies an rna ligase family that includes the rna editing ligases (rels) of trypanosoma and leishmania. the rnl2/rel enzymes are defined by essential signature residues and a unique c-terminal domain, which we show is essential for sealing of 3'-oh and 5'-po4 rna ends by rnl2, but not for ligase adenylation or phosphodiester bond formation at a preadenylated apprna end. the n-terminal segment rnl2(1-249) of the 334 aa rnl2 protein comprises an autonomous adenylyltrans ... | 2004 | 14962393 |
| effects of hypothyroidism on the estrous cycle and reproductive hormones in mature female rat. | the present study was undertaken to examine the systemic role of thyroid hormones by analyzing changes in reproductive functions in hypothyroid female rats. serum concentrations of triiodo-thyronine (t3) significantly decreased 1 week after the initiation of propyl-thiouracil treatment or thyroidectomy. the estrous cycle became irregular 3 and 2 weeks after the initiation of propyl-thiouracil treatment and thyroidectomy, respectively. serum luteinizing hormone (lh) levels significantly reduced i ... | 2004 | 14985057 |
| study of trace elements in blood of thyroid disorder subjects before and after 131i therapy. | both trace elements and thyroid hormones play essential roles in the human body. however, the previous results about the interaction between these two factors are often controversially given. in order to make clear the influence of thyroid hormones on the homeostasis of trace elements, we studied the variation of fe, cu, and zn in erythrocyte and serum from patients with hyperthyroidism before and after 131i therapy by the x-ray fluorescence method. the different thyroid statuses of the patients ... | 2004 | 14985623 |
| mice with targeted disruption of the dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. | the dio2 gene encodes the type 2 deiodinase (d2) that activates thyroxine (t4) to 3,3',5-triiodothyronine (t3), the disruption of which (dio2(-/-)) results in brown adipose tissue (bat)-specific hypothyroidism in an otherwise euthyroid animal. in the present studies, cold exposure increased dio2(-/-) bat sympathetic stimulation approximately 10-fold (normal approximately 4-fold); as a result, lipolysis, as well as the mrna levels of uncoupling protein 1, guanosine monophosphate reductase, and pe ... | 2004 | 14988240 |
| increasing incidence of childhood thyrotoxicosis in a population-based area of central sweden. | to study the incidence, prevalence and clinical characteristics of childhood thyrotoxicosis in a population-based area comprising five counties in central sweden. | 2004 | 14989435 |
| pet with [18f]fluorothymidine for imaging of primary breast cancer: a pilot study. | the aim of this study was to evaluate the use of [(18)f]fluorothymidine (flt) as a positron emission tomography (pet) tracer for the diagnosis of breast cancer. to this end, 12 patients with 14 primary breast cancer lesions (t2-t4) were studied by flt-pet. for comparison, [(18)f]fluorodeoxyglucose (fdg) pet scans were performed in six patients. thirteen of the 14 primary tumours demonstrated focally increased flt uptake (suv(mean)=3.4+/-1.1). seven out of eight patients with histologically prove ... | 2004 | 14991243 |
| reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas. | the effects of selenium, an essential nutrient with anti-carcinogenic properties, are mediated by selenium-binding proteins. the protein expression status of human selenium-binding protein 1 (sbp1) in human tumours and the exact function of this protein are not known. in this study, quantitative two-dimensional polyacrylamide gel electrophoresis (2-d page) was used on 93 lung adenocarcinomas and ten uninvolved lung samples. two likely isoforms of a 56 kd protein that showed a significantly decre ... | 2004 | 14991897 |
| rna ligase; picking up the pieces. | in the current issue of structure, ho and coworkers report the crystal structure and mechanism of a t4 rna ligase. these studies provide valuable insights on the mechanism and origin of rna and dna ligases, and rna capping enzymes. | 2004 | 14992715 |
| peripheral intrapulmonary lymph node metastases of non-small-cell lung cancer. | since the development and progress of computed tomographic imaging, peripheral intrapulmonary lymph nodes (iplns) have become increasingly described and well-known entities. intrapulmonary lymph nodes may appear as a solitary pulmonary nodular shadow mimicking a non-small-cell lung cancer (nsclc) or as multiple nodules masquerading as carcinoma metastases. we describe a case in which iplns presented as a clinical "nodular" t4 n0 nsclc that finally proved to be a pathologic t2 n1 nsclc, thus rais ... | 2004 | 14992944 |
| role of endoscopic ultrasonography in preoperative staging of gastric carcinoma. | preoperative staging of tumour extent in upper gastrointestinal malignancy greatly facilitates planning of therapy. the present study was undertaken to see whether preoperative endoscopic ultrasonography (eus) accurately predicts the tumour stage in gastric carcinoma. | 2004 | 14996154 |
| accuracy of eus in staging of t4 lung cancer. | increasingly, eus is being used to stage lung cancer. direct mediastinal invasion (t4) by lung cancer is stage iiib disease. patients in this stage have a 5-year survival of less than 5% and generally are offered chemotherapy without surgery. this study evaluated the accuracy of eus in detecting t4 lung cancer. | 2004 | 14997129 |
| phase ii study of neoadjuvant paclitaxel and cisplatin for operable and locally advanced breast cancer: analysis of 126 patients. | in an earlier study, we have demonstrated a high clinical and pathologic response rate of neoadjuvant paclitaxel (p) and cisplatin (c) for patients with locally advanced breast cancer (labc). the current phase ii study includes larger number of patients who had longer follow-up. a total of 126 consecutive patients with noninflammatory labc (t2 >4 cm, t3 or t4, n0-n3, m0) were included in the study. patients were scheduled to receive three to four cycles of the neoadjuvant pc (paclitaxel 135 mg m ... | 2004 | 14997191 |
| effect of iodinated contrast media on thyroid function in adults. | excess free iodide in the blood (ingested or injected) may cause thyrotoxicosis in patients at risk. iodinated contrast medium solutions contain small amounts of free iodide and may be of significance for patients at risk. the free iodide may also interfere with nuclear medicine diagnostic studies and treatment. therefore the contrast media safety committee of the european society of urogenital radiology reviewed the literature on this subject in order to prepare guidelines. a report and guideli ... | 2004 | 14997334 |
| perioperative levels of interleukin-1beta and interleukin-6 in women with breast cancer. | proinflammatory cytokines, such as interleukin-1beta and interleukin-6, are known to play an important biological role in trauma, sepsis and malignant disease. surgery can modulate the immune system, especially in patients with malignant diseases, by influencing the serum levels of interleukin-1beta and interleukin-6. it is known that cytokine levels depend on the grade of tissue injury. we have investigated the serum levels of interleukin-1beta and interleukin-6 during the perioperative period ... | 2004 | 14998180 |
| assessment of de-71, a commercial polybrominated diphenyl ether (pbde) mixture, in the edsp male and female pubertal protocols. | de-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active chemicals. these protocols are being evaluated for the u.s. epa's endocrine disruptor screening program as part of a tier i screening battery. to examine the ability of these protocols to screen for chemicals that induce the clearance of thyroid hormone, we examined male and female wistar rats following de-71 exposure. rats were gavaged daily with 0, 3, 30, or 60 mg/kg ... | 2004 | 14999130 |
| evaluation of the effects of radiotherapy to the chiasm and optic nerve by visual psychophysical and electrophysiologic tests in nasopharyngeal carcinoma. | to evaluate the effects of high-dose radiotherapy (rt) to the chiasm and optic nerves in locally advanced nasopharyngeal carcinoma patients by visual psychophysical and electrophysiologic tests. | 2004 | 15001256 |
| the importance of aprotinin and pentoxifylline in preventing leukocyte sequestration and lung injury caused by protamine at the end of cardiopulmonary bypass surgery. | protamine has adverse effects on pulmonary gas exchange during the postoperative period. the objective of this study was to investigate the importance of aprotinin and pentoxifylline in preventing the leukocyte sequestration and lung injury caused by protamine administered after the termination of cardiopulmonary bypass (cpb). | 2004 | 15002070 |
| clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients. | the presence of tumor cells in bone marrow has been reported to represent an important prognostic indicator in breast cancer, but the clinical significance of circulating cells in peripheral blood is less well known. the aim of this study was to evaluate the feasibility of identifying cytokeratin (ck)-expressing cells in peripheral blood with an automat-assisted immunohistochemical detection system and to compare it with detection of tumor cells in bone marrow samples. | 2004 | 14977842 |
| correlation between oxygen consumption calculated using fick's method and measured with indirect calorimetry in critically ill patients. | to compare the oxygen consumption index measured by using indirect calorimetry (vo2i delta) with a portable metabolic cart and calculated according to fick's principle (vo2 i fick) in critically ill patients. | 2004 | 14978596 |
| [vertebral hemangioma extending into the spinal canal: case report]. | a 73-year-old woman was admitted to our hospital presenting slowly progressive hypoesthesia below the 5th thoracic dermatome and spastic paraparesis. computed tomography (ct) and magnetic resonance imaging (mri) revealed a mass lesion in the t3 vertebral body extending into the spinal canal. the spinal cord was compressed to the left side and right t3 and t4 nerve roots were encased in the mass lesion. one week after admission, t2-t4 laminectomy was performed to relieve the spinal cord compressi ... | 2004 | 14978923 |
| laparoscopic gastric bypass in patients on thyroid replacement therapy for subnormal thyroid function - prevalence and short-term outcome. | hypothyroidism is associated with increased body weight. weight gain may occur despite normal levels of serum thyroid stimulating hormone (tsh) and thyroxine (t4) achieved by replacement therapy. we evaluated the prevalence of patients on thyroid replacement for subnormal thyroid function who were operated on for morbid obesity and monitored their postoperative weight loss pattern. | 2004 | 14980041 |
| l-homoserylaminoethanol, a novel dipeptide alcohol inhibitor of eukaryotic dna polymerase from a plant cultured cells, nicotina tabacum l. | we found a novel inhibitor specific to eukaryotic dna polymerase epsilon(pol epsilon) from plant cultured cells, nicotina tabacum l. the compound (compound 1) was a dipeptide alcohol, l-homoserylaminoethanol. the 50% inhibition of pol epsilon activity by the compound was 43.6 microg/ml, and it had almost no effect on the activities of the other eukaryotic dna polymerases such as alpha, beta, gamma and delta, prokaryotic dna polymerases, nor dna metabolic enzymes such as human telomerase, human i ... | 2004 | 14980608 |
| thyroid function and the development of endothermy in a marsupial, the tasmanian bettong, bettongia gaimardi (demarest 1822). | the tasmanian bettong (bettongia gaimardi) is a small rat-kangaroo (marsupial) found only in tasmania, australia. the duration of pouch life is 15 weeks. adults and older young display non-shivering thermogenesis and this paper examines the role of thyroxine in the development of endothermy in pouch young. free thyroxine (t4) concentrations varied throughout pouch life. the mean (+/-se) concentration was 6.2+/-1.9 pmol l(-1) in week 7, increased and peaked at 19.2+/-4.3 pmol l(-1) in week 12, an ... | 2004 | 14980792 |
| low dose exposure to sodium arsenite synergistically interacts with uv radiation to induce mutations and alter dna repair in human cells. | inorganic arsenic is a known human carcinogen, yet its mechanism of action remains poorly understood. epidemiological data suggest that arsenic exposure interacts with uv radiation exposure to increase the risk of skin cancer. studies have suggested that arsenic is able to impair dna repair enzymes and alter the repair of uv-induced dna damage. here we have tested the hypothesis that arsenite [as(iii)] and uv interact synergistically to enhance mutagenesis. tk6 human lymphoblastoid cells that ar ... | 2004 | 14981161 |
| initial experience using intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma. | to report our initial experience on the feasibility, toxicity, and tumor control using intensity-modulated radiotherapy (imrt) for retreatment of recurrent nasopharyngeal carcinoma (npc). | 2004 | 14967420 |
| characterization of bacteriophage kvp40 and t4 rna ligase 2. | bacteriophage t4 rna ligase 2 (rnl2) exemplifies a subfamily of rna strand-joining enzymes that includes the trypanosome rna editing ligases. a homolog of t4 rnl2 is encoded in the 244-kbp dna genome of vibriophage kvp40. we show that the 335-amino acid kvp40 rnl2 is a monomeric protein that catalyzes rna end-joining through ligase-adenylate and rna-adenylate (apprna) intermediates. in the absence of atp, pre-adenylated kvp40 rnl2 reacts with an 18-mer 5'-po(4) single-strand rna (prna) to form a ... | 2004 | 14967495 |
| postoperative adjuvant chemoradiotherapy in older patients with head and neck cancer. | in head and neck cancer, the locoregional failure of patients with positive margins, vascular or perineural invasion, and extracapsular spread is high and results in poor survival. | 2004 | 14967744 |
| models of phage growth and their applicability to phage therapy. | phage therapy is complicated by the self-replicating nature of phage. it is difficult to extrapolate from in vitro phage growth data to in vivo expectations, difficult to interpret in vivo data and difficult to generalize from one in vivo situation to another. various generic models of phage growth have been used as the theoretical basis for understanding the kinetics of phage therapy. here, we have experimentally tested the efficacy of such simple models to predict, qualitatively and quantitati ... | 2004 | 14969703 |
| recurrent carcinoma of the head and neck: treatment strategies and survival analysis in a 20-year period. | following clinical diagnosis of a recurrent tumor, curative treatment is seldom available. depending on the size of the recurrent tumor and the patient's general health condition extensive surgical resections and reconstructions are avoided in favor of non-surgical palliative intended treatment modalities. according to the literature location of the tumor, tumor size, as well as r-1- and r-2-resection rates are the most frequent reasons for the development of recurrent tumors. in a retrospective ... | 2004 | 14969822 |
| plasma levels of tumor necrotic factor-alpha and interleukin-6, -8 during orthotopic liver transplantation and their relations to postoperative pulmonary complications. | pulmonary complications after orthotopic liver transplantation (olt) include high morbidity and mortality. experimental data have suggested hepatic ischemia and reperfusion are induced by pro-inflammatory cytokines. the high level of inflammatory cytokines might additionally influence pulmonary capillary fluid filtration. the objectives of this study were to measure the concentrations of tumor necrotic factor-alpha (tnf-alpha), interleukin-6 (il-6) and interleukin-8 (il-8) during olt and to inve ... | 2004 | 14969835 |
| changes in exercise performance and hormonal concentrations over a big ten soccer season in starters and nonstarters. | as a consequence of the physiological demands experienced during a competitive soccer season, the antagonistic relationship between anabolic and catabolic processes can affect performance. twenty-five male collegiate soccer players were studied throughout a season (11 weeks) to investigate the effects of long-term training and competition. subjects were grouped as starters (s; n = 11) and nonstarters (ns; n = 14). measures of physical performance, body composition, and hormonal concentrations (t ... | 2004 | 14971972 |
| liver transplantation in patients with hepatocellular carcinoma: factors implicated in tumor relapse. | liver segmental resection and liver transplantation are both treatments intended for healing liver cancer. an adequate selection of patients eligible for transplantation is crucial, since organs available for transplants are usually scarce. for this reason, awareness of the prognostic factors of relapse is of great importance. we present a comprehensive review of our series in order to better understand these prognostic factors. | 2004 | 14971994 |
| portability and fidelity of rna-repair systems. | yeast trna ligase (trl1) is an essential enzyme that converts cleaved trna half-molecules into spliced trnas containing a 2'-po(4), 3'-5' phosphodiester at the splice junction. trl1 also catalyzes splicing of hac1 mrna during the unfolded protein response. trl1 performs three reactions: the 2',3'-cyclic phosphate of the proximal rna fragment is hydrolyzed to a 3'-oh, 2'-po(4) by a cyclic phosphodiesterase; the 5'-oh of the distal rna fragment is phosphorylated by a gtp-dependent polynucleotide k ... | 2004 | 14973195 |
| small renal cell carcinomas: correlation of size with tumor stage, nuclear grade, and histologic subtype. | our goal was to correlate the size of renal cell carcinoma with tumor stage, nuclear grade, and histologic subtype in patients treated using partial or radical nephrectomy. | 2004 | 14975944 |
| enhanced rat hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators. | development of an internationally recognized standard for the hershberger assay as a screening tool to detect potential (anti-)androgenic chemicals is in progress. in the present preliminary study, we evaluated the reliability of the enhanced hershberger assay to detect thyroid hormone modulating activity, while concentrating attention on possible confounding influence on evaluation of (anti-)androgenic activity. castrated or testosterone propionate (tp; 0.2 or 0.25 mg/kg/day)-injected castrated ... | 2004 | 14976338 |
| total laryngectomy and postoperative radiotherapy for t4 laryngeal cancer: a 14-year review. | the most appropriate treatment of locally advanced carcinoma of the larynx remains to be ascertained. management of t4 laryngeal cancer patients with postoperative radiotherapy after total laryngectomy is generally advocated and not often debated. however, the effects of this combined treatment approach are poorly documented. we reviewed the oncologic outcome and long-term survival of individuals treated by total laryngectomy and postoperative radiotherapy (tlpr) for t4 carcinoma of the larynx. | 2004 | 14976652 |
| solution structures of reduced and oxidized bacteriophage t4 glutaredoxin. | 2004 | 15017142 | |
| putative l-triiodothyronine receptors in the liver nuclei of mature tropical toad, bufo melanostictus. | thyroid hormones exert a major role in growth and differentiation of almost all types of tissues in animals, particularly in amphibian metamorphosis, through its specific nuclear receptor activation followed by gene expression. however, its function in mature tropical amphibians is less studied. the present study revealed the existence of a single class of specific nuclear receptor(s) in the liver nuclei of mature tropical toad, bufo melanostictus, with a dissociation constant of (3.7 +/- 0.9) x ... | 2004 | 15018064 |
| altered thyroid status in lake trout (salvelinus namaycush) exposed to co-planar 3,3',4,4',5-pentachlorobiphenyl. | recent studies indicate that co-planar 3,3',4,4',5-pentachlorobiphenyl (pcb) congeners or their metabolites may disrupt thyroid function in fishes. although co-planar pcb have been detected at microgram per kilogram levels in fish from contaminated areas, few studies have examined mechanisms whereby, co-planar pcbs may alter thyroid function in fish. we treated immature lake trout by intraperitoneal (i.p.)-injection or dietary gavage with vehicle containing 0, 0.7, 1.2, 25 or 40 microg 3,3',4,4' ... | 2004 | 15019252 |
| chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. | the cytosine base in dna undergoes hydrolytic deamination at a considerable rate when uv radiation induces formation of a cyclobutane pyrimidine dimer (cpd) with an adjacent pyrimidine base. we have synthesized a phosphoramidite building block of a cis-syn cyclobutane thymine-uracil dimer (t[]u), which is the deaminated form of the cpd at a tc site, and incorporated it into oligodeoxyribonucleotides. the previously reported method for synthesis of the thymine dimer (t[]t) was applied, using part ... | 2004 | 15020710 |
| comparison of plasma epstein-barr virus (ebv) dna levels and serum ebv immunoglobulin a/virus capsid antigen antibody titers in patients with nasopharyngeal carcinoma. | serologic measurement of antibodies to epstein-barr virus (ebv) immunoglobulin a/viral capsid antigen (iga/vca) and early antigen (iga/ea) has been used widely to screen for nasopharyngeal carcinoma (npc) in china. recently, it was found that plasma ebv dna concentration is an indicator for the staging and prognosis of patients with npc. to determine whether there is a correlation between plasma ebv dna levels and serum levels of iga/vca, the authors measured both in patients with npc and in a c ... | 2004 | 15022282 |
| quality of colon carcinoma pathology reporting: a process of care study. | in 1996, the association of directors of anatomic and surgical pathology (adasp) published recommendations for colon carcinoma reporting. since this publication, no study has evaluated physician practice in relation to these recommendations. the objectives of the current study were to describe pathology reporting for colon carcinoma, evaluate potential variations in reporting, and identify areas for improvement. | 2004 | 15022295 |
| [diagnosis and treatment of bladder cancer]. | the authors present a retrospective analysis of the results of transurethral conservative and radical operations in 125 patients with invasive cancer of the urinary bladder (ub) treated in the research institute of urology throughout 1992-2002. transurethral resection (tur) of the ub was made in 72 patients. stages pt2a, pt2b, t3 and t4 were diagnosed in 23 (31.9%), 18 (25%), 14 (19.5%) and 17 (23.6%) cases, respectively. 53 patients with advanced invasive ub cancer have undergone radical cystec ... | 2004 | 15022437 |
| [role of thyroid hormones in regulation of heart function]. | current data on mechanisms of action of thyroid hormones--t3 and t4--on molecular, cellular and organic organs obtained in experimental and clinical conditions are reviewed. the results of examination of patients with hypo- and hyperthyroidism as well as some clinical syndromes (heart arrhythmia, heart failure) have shown physiological and pathophysiological participation of thyroid hormones in regulation of cardiac activity at the level of hemodynamics and myocardial metabolism. | 2004 | 15022589 |
| [hormonal dysregulation of lipid metabolism in pathogenesis of ischemic heart disease]. | the aim of the study was to specify postprandial hyperlipidemia (phl) and the level of hormones which regulate metabolism, lipids in particular, in patients with ischemic heart disease (ihd) vs those in healthy persons and patients with thyrotoxicosis as well as to clarify whether ihd pathogenesis correlates with fat metabolism disturbance. lipid and apoprotein parameters of dyslipoproteinemia, concentrations of insulin, hydrocortisone, t3, t4 and thyrotropic hormone were tested before and 3, 6 ... | 2004 | 15022592 |
| role of radiation therapy for facial skin cancers. | radiation therapy is one of many modalities that should be considered and explained to patients with basal cell carcinomas and squamous cell carcinomas of the head and neck (fig. 2). control rates for appropriately selected patients should exceed 90% and historically are comparable with most surgical resections. for locally advanced t4 lesions, a combined modality approach will give the best chance at local control. postoperative radiation therapy is indicated in patients with advanced lesions, ... | 2004 | 15022791 |
| ligating dna with dna. | cloning dna typically involves the joining of target dnas with vector constructs by enzymatic ligation. a commonly used enzyme for this reaction is bacteriophage t4 dna ligase, which requires atp as the energy source to catalyze the otherwise unfavorable formation of a phosphodiester bond. using in vitro selection, we have isolated a dna sequence that catalyzes the ligation of dna in the absence of protein enzymes. we have used the action of two catalytic dnas, an atp-dependent self-adenylating ... | 2004 | 15025472 |
| differential expression of iodothyronine deiodinase type 2 in growth plates of chickens divergently selected for incidence of tibial dyschondroplasia. | tibial dyschondroplasia (td) is a genetic leg defect in broilers with a lesion of avascular, non-calcified cartilage below the growth plate of the proximal tibiatarsus. this disease is considered to result from the inability of chondrocytes to undergo terminal differentiation. thyroid hormones are required for chondrocyte differentiation. the thyroid gland produces and secrets mostly l-thyroxine or t4 and t4 plays most of its biological activities through conversion to triiodothyronine or t3 in ... | 2004 | 15025570 |
| distribution, sequence homology, and homing of group i introns among t-even-like bacteriophages: evidence for recent transfer of old introns. | self-splicing group i introns are being found in an increasing number of bacteriophages. most introns contain an open reading frame coding for a homing endo-nuclease that confers mobility to both the intron and the homing endonuclease gene (heg). the frequent occurrence of intron/heg has raised questions whether group i introns are spread via horizontal transfer between phage populations. we have determined complete sequences for the known group i introns among t-even-like bacteriophages togethe ... | 2004 | 15026408 |
| prognostic variables for cancer-related survival in node-negative colorectal carcinomas. | the efficacy of adjuvant treatment in node-negative colorectal carcinoma is unproven. the purpose of this study was to analyze the prognostic value of routinely detectable clinicopathological variables in order to identify subgroups of node-negative colorectal cancer patients at a high risk of a recurrence. | 2004 | 15026608 |
| alterations in thyroid hormone concentrations in healthy sled dogs before and after athletic conditioning. | to determine effects of athletic conditioning on thyroid hormone concentrations in a population of healthy sled dogs. | 2004 | 15027682 |
| expression of the p65 gene in patients with colorectal cancer: comparison with some histological typing, grading and clinical staging. | p65 protein/gene is a potential, non-specific tumour marker expressed by different types of neoplasms. in this study p65 gene expression was estimated in a group of colorectal cancers and compared with some histological features, grading and clinical staging of the neoplasms to assess its role as a prognostic marker for colorectal cancer. | 2004 | 15028307 |
| the clinicopathological significance of inferior mesenteric lymph node metastasis in colorectal cancer. | there are few studies reporting survival or recurrence patterns in colorectal cancer patients with inferior mesenteric lymph node metastasis (imln+). the present study evaluated the prognostic significance of patients being imln+ or imln- in colorectal cancer. | 2004 | 15028308 |
| accelerated postoperative radiotherapy with weekly concomitant boost in patients with locally advanced head and neck cancer. | to assess the feasibility and efficacy of accelerated 66-gy postoperative radiotherapy (port) using a single-fraction regimen from mondays to thursdays and a concomitant boost on friday afternoon sessions in patients with locally advanced head and neck cancer (lahnc). | 2004 | 15028406 |