Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment. | the current study was performed to determine the incidence of central nervous system (cns) metastases and to examine associated disease characteristics in a group of patients with locally advanced breast carcinoma (labc) or inflammatory breast carcinoma (ibc) treated at the university of texas m. d. anderson cancer center (houston, tx). | 2004 | 15386311 |
| differences in health-related quality of life of prostate cancer patients based on stage of cancer. | understanding medical factors that influence quality of life for men with prostate cancer is an important goal. this study analysed the relationship between cancer stage and quality of life, including measures of physical and psychological well-being. | 2004 | 15386638 |
| a long-term study on the expansion effects of the cervical-pull facebow with and without rapid maxillary expansion. | this study evaluates the long-term stability of maxillary expansion achieved by widening the inner bow of a facebow, with or without concurrent rapid maxillary expansion (rme) (haas type), followed by treatment with fixed edgewise appliances. the parent sample included 154 nonextraction patients who started their orthodontic treatment during a defined time period. the exclusion criteria reduced the number of patients to 61 in the cervical-pull facebow group (cfb) and 41 in the rme-cfb group. all ... | 2004 | 15387020 |
| the selenium requirement of the puppy. | current selenium (se) recommendations for the puppy are based on extrapolation from other species (0.11 mg se/kg diet). the purpose of this study was to experimentally determine the se requirement in puppies. thirty beagle puppies (average = 8.8 weeks old) were utilized in a randomized complete block design with age, litter and gender used as blocking criteria. puppies were fed a low se (0.04 mg se/kg diet) torula yeast-based diet for 14 days (pre-test period) after which this same diet was supp ... | 2004 | 15387850 |
| use of an ion-binding site to bypass the 1000-atom limit to structure determination by direct methods. | proteins with more than 1000 non-h atoms and without heavy-atom prosthetic groups are very difficult to solve by ab initio direct methods. t4 lysozyme is being used to explore these limits. the protein has 1309 non-h atoms, seven s atoms, no disulfide bonds and no heavy-atom prosthetic group. it is recalcitrant to structure determination by direct methods using x-ray diffraction data to 0.97 a. it is shown here that it is possible to obtain a truly ab initio structure determination of a variant ... | 2004 | 15388918 |
| pectoralis major and other myofascial/myocutaneous flaps in head and neck cancer reconstruction: experience with 437 cases at a single institution. | pectoralis major and other myofascial/myocutaneous flaps have been recognized as important reconstructive methods in head and neck cancer surgery. even with the worldwide use of free flaps, they are still the mainstay reconstructive procedures in many centers. | 2004 | 15390191 |
| the influence of the pattern of mandibular invasion on recurrence and survival in oral squamous cell carcinoma. | controversy exists over the predictive value of the presence and pattern of tumor invasion of the mandible in oral squamous cell carcinoma (scc). many authors have questioned increasing the classification of small tumors to t4 on the basis of mandibular invasion alone. there are little data on the influence of the pattern of invasion on prognosis. | 2004 | 15390204 |
| [the lanthanide fluorescence immunoassay of the total thyroxin in dried bloodstains on paper]. | the lanthanide fluorescence immunoassay was elaborated for quantitative determination of the total thyroxin t4 in bloodstain dried in filter paper; the fields of its clinical application were defined. the method is based on the hardphase concurrent immunoassay with specific monoclonal antibodies to t4 marked by chelates of europium ions and with conjugate of the t3 heterologous hapten sorbed in plate holes with bovine serum albumin. measurements of the fluorescence intensity were made by a fluor ... | 2004 | 15460993 |
| on the solution structure of the t4 sliding clamp (gp45). | examination by time-resolved fluorescence spectroscopy of the trimeric bacteriophage t4 clamp protein labeled across its three subunit interfaces with a fluorescence resonance energy transfer (fret) pair indicates that the clamp exists in just one state in solution, with one open and two closed interfaces. this is in contrast to what is observed in the x-ray crystal structure. the population distribution of the trfret distance is bimodal, giving 67% as 17 a and 33% as 42 a. this leads to the con ... | 2004 | 15461444 |
| thyroid hormone transport is disturbed in erythrocytes from patients with chronic renal failure on hemodialysis. | to now, there are no studies reporting whether thyroid hormones (ths) transport play a role in thyroid hormone dysfunction observed in chronic renal failure (crf). therefore, the aim of this study was to investigate the transport of ths in erythrocytes from patients with crf on hemodialysis (hd). | 2004 | 15462116 |
| [the supracricoid laryngectomy with cricohyoidopexy. carcinological and functional results. 23 cases report of the centre a. lacassagne (nice)]. | this study is to estimate the survival results, the morbidity and the functional consequences of the supracricoid laryngectomy with cricohyoïdopexy (sl-chp). | 2004 | 15462171 |
| vitamin e prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in pvc blood storage bags. | vitamin e administration prevented dehp induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane na+ - k+ atpase, (iii) decrease in the concentration of insulin, cortisol and tsh, and (iv) the increase in t3 and t4 in female albino rats. the results suggest use of vitamin e to prevent harmful effects of repeated transfusion of dehp containing blood as in thalassemia patient. the possibility of using vitamin e to preven ... | 2004 | 15462179 |
| combined resection of superior vena cava for lung carcinoma: prognostic significance of patterns of superior vena cava invasion. | combined resection of the superior vena cava (svc) for lung carcinoma remains challenging in terms of technical aspect and prognosis. we attempted to clarify the surgical outcome of combined resection and reconstruction of the svc for lung carcinoma. | 2004 | 15464467 |
| escherichia coli detection by gfp-labeled lysozyme-inactivated t4 bacteriophage. | escherichia coli has been used as an indicator of the fecal contamination of water and food, identifying potential health hazards. in this study, an e. coli-specific bacteriophage, t4, was used to detect e. coli bacteria. the t4 phage small outer capsid (soc) protein was used to present green fluorescent protein (gfp), an easily detectable marker protein, on the phage capsid. to inactivate phage lytic activity, we used the t4e(-) phage, which does not produce the lysozyme responsible for host ce ... | 2004 | 15464594 |
| vasoactive intestinal peptide can modulate immune and endocrine responses during lipopolysaccharide-induced acute inflammation. | in many studies, it has been reported that vasoactive intestinal peptide (vip) may play an important role in modulation of the immunological response. vip can be produced by immunological cells, and also the receptors for this neuropeptide are present in many of these cells. the aim of our study was to estimate the effects of the administration of exogenous vip on serum concentrations of proinflammatory cytokines [interleukin (il)-6 and tumor necrosis factor (tnf)-alpha] and an anti-inflammatory ... | 2004 | 15467350 |
| efficacy of routine bilateral neck dissection in the management of supraglottic cancer. | in a previous study, we reported that the contralateral undissected neck was the most common site of failure in patients treated for squamous cell carcinoma of the supraglottic larynx. since then, we have altered our treatment of all patients with t2-t4 supraglottic cancer and selective t1 cases to include routine bilateral neck dissection. in the present study, we compare the long-term efficacy of routine bilateral neck dissections to historic controls in the treatment of patients with supraglo ... | 2004 | 15467622 |
| is the delay in starting postoperative radiotherapy a key factor in the outcome of advanced (t3 and t4) laryngeal cancer? | to identify factors influencing the outcome of postoperative radiotherapy in patients with advanced laryngeal cancer. | 2004 | 15467623 |
| trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays. | accurate assessment of the pregnant woman's thyroid status is critical, for both the initiation of thyroid hormone therapy and for the adjustment of thyroid hormone dose in those already receiving thyroid hormone. trimester-specific intervals are especially important during pregnancy when thyroid insufficiency may be associated with adverse obstetric outcome and fetal neurodevelopmental deficits. we defined pregnancy-specific reference intervals for thyroxine (t4) and 3,5,3'-triiodothyronine (t3 ... | 2004 | 15469872 |
| multi-organic endocrine disrupting activity of the uv screen benzophenone 2 (bp2) in ovariectomized adult rats after 5 days treatment. | the chemical industry has developed sun protection factor products, which contain a variety of so-called "uv screens", among others, benzophenones (bp). based on the structure it can be assumed, that the variant bp2 may be a potent estrogenic endocrine disrupter (ed). only very limited data are available in the literature about such action of bp2, which focussed on the uterotrophic effect in immature rats. however, determination of ed activity in the uterus is only a restricted approach with the ... | 2004 | 15458793 |
| endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney. | to assess interference with endocrine regulation of the thyroid axis, rats (female, ovariectomised) were treated for 12 weeks with the suspected endocrine active compounds (eac) or endocrine disrupters (ed) 4-nonylphenol (np), octyl-methoxycinnamate (omc) and 4-methylbenzylidene-camphor (4-mbc) as well as 17beta-estradiol (e2) and 5alpha-androstane-3beta,17beta-diol (adiol) on the background of a soy-free or soy-containing diet, and endpoints relevant for regulation via the thyroid axis were mea ... | 2004 | 15458794 |
| long-term follow-up of a pilot phase ii study with neoadjuvant epidoxorubicin, etoposide and cisplatin in gastric cancer. | the prognosis in t3-t4 or n+ gastric cancer is dismal, and the role of adjuvant therapy remains uncertain. neoadjuvant chemotherapy could improve both resectability and survival. here, we report the results of the long-term follow-up of a pilot study aimed at evaluating a neoadjuvant treatment in a group of patients carefully staged by computed tomography (ct), endoscopic ultrasound and laparoscopy. | 2004 | 15459495 |
| evaluation of arm-leg coordination in flat breaststroke. | this study proposes a new method to evaluate arm-leg coordination in flat breaststroke. five arm and leg stroke phases were defined with a velocity-video system. five time gaps quantified the time between arm and leg actions during three paces of a race (200 m, 100 m and 50 m) in 16 top level swimmers. based on these time gaps, effective glide, effective propulsion, effective leg insweep and effective recovery were used to identify the different stroke phases of the body. a faster pace correspon ... | 2004 | 15459828 |
| co2 laser surgery: a larynx preservation alternative for selected hypopharyngeal carcinomas. | transoral co2 laser surgery (tls) has demonstrated good oncologic results and low morbidity in the treatment of selected laryngeal carcinomas, but experience in hypopharyngeal carcinomas (hc) is limited. the aim of this study was to evaluate the usefulness of tls in the treatment of selected hc. | 2004 | 15459928 |
| effect of hypothyroidism on the blood lipid response to higher dietary fat intake in mares. | blood lipid and lipoprotein concentrations were measured and compared between euthyroid and thyroidectomized mares on low-fat or high-fat diets to test the hypothesis that hypothyroidism alters the blood lipid response to higher dietary fat intake. four healthy adult mares and four adult mares that had been thyroidectomized 3 to 6 mo earlier were placed on low-fat or high-fat diets according to a replicated 2 x 2 latin square design consisting of two 5-wk feeding periods separated by a 2-wk wash ... | 2004 | 15446481 |
| nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized controlled trial. | very low birth weight infants (<1500 g) have high nutritional needs. deficiencies of minerals, trace elements (especially zinc) may develop as a result of rapid growth, low body stores and low content of these substances in human milk we hypothesized that fortification of human milk might prevent deficiencies. | 2004 | 15448423 |
| thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. | oligodendrocyte development and myelination are under thyroid hormone control. in this study we analysed the effects of chronic manipulation of thyroid status on the expression of a wide spectrum of oligodendrocyte precursor cells (opcs) markers and myelin basic protein (mbp) in the subventricular zone (svz), olfactory bulb and optic nerve, and on neural stem cell (nsc) lineage in adult rats. hypo- and hyperthyroidism were induced in male rats, by propyl-thio-uracil (ptu) and l-thyroxin (t4) tre ... | 2004 | 15450085 |
| unique ligation properties of eukaryotic nad+-dependent dna ligase from melanoplus sanguinipes entomopoxvirus. | the eukaryotic melanoplus sanguinipes entomopoxvirus (msepv) genome reveals a homologous sequence to eubacterial nicotinamide adenine dinucleotide (nad(+))-dependent dna ligases [j. virol. 73 (1999) 533]. this 522-amino acid open reading frame (orf) contains all conserved nucleotidyl transferase motifs but lacks the zinc finger motif and brct domain found in conventional eubacterial nad(+) ligases. nevertheless, cloned msepv ligase seals dna nicks in a nad(+)-dependent fashion, while adenosine 5 ... | 2004 | 15450174 |
| directional ligation of long-flanking homology regions to selection cassettes for efficient targeted gene-disruption in candida albicans. | pcr-product directed gene disruption with a marker cassette having short homology regions is often used in candida albicans. however, it is quite inefficient due to the high frequency of non-homologous recombination at non-targeted loci, which necessitates extensive screening to identify the correct disruptants. thus, many pcr-based methods to introduce long flanking homology regions have been developed to increase the frequency of integration at the targeted loci. however, these methods are not ... | 2004 | 15450191 |
| mediastinoscopic ultrasonography (mus). | correct pre-therapeutic t4 staging is mandatory for neo-adjuvant studies and for the decision on surgical therapy of high-risk patients. t4-staging of centrally located lung-cancer by means of non-invasive imaging techniques is either of low accuracy (ct and nmr) or important regions are not accessible due to air interference with the tracheo-bronchial tree (trans-esophageal-endosonography, tee). we here describe for the first time the new technique of mediastinoscopic ultrasonography (mus). a f ... | 2004 | 15450590 |
| bag-1 expression as a prognostic factor in tongue squamous cell carcinomas. | to investigate the prognostic significance of the antiapoptotic protein bag-1. in addition, the relationship between bag-1 expression, other apoptosis-related and proliferative parameters. | 2004 | 15454773 |
| acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia: role of nadph oxidase. | we examined the effects of acute hyperglycemia on the function of rabbit cerebral arteries in vitro. it was hypothesized that increased formation of reactive oxygen species (ros) could occur, which could explain how hyperglycemia aggravates certain pathologic situations such as cerebral ischemia. three-millimeter basilar artery segments were incubated in either normoglycemic (ng, 5.5 mm d-glucose) or hyperglycemic (hg, 25 mm d-glucose) solution containing 3.10(-6) m indomethacin. after 90 minute ... | 2004 | 15454861 |
| [membranous nephropathy associated to autoimmune thyroiditis, chronic pancreatitis and suprarrenal insufficiency]. | a 33 year old female was admitted to the hospital to study aedema and bocio, a nephrotic syndrome was diagnosed and the renal biopsy demonstrated membranous glomerulonephritis, stage ii. she was also diagnosed of hashimoto's autoinmmune thyroiditis: tsh (41.5 uul/ml), t4 (0.07 ng/dl), antithyroglobuline (1/2560) and antimicrosome (1/6400). four year latter she was diagnosed of autoinmmune pancreatitis, without evidence of diabetes mellitus or exocrine pancreatic insufficiency. eight years latter ... | 2004 | 15455500 |
| association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and tsh-suppressed nodular goitre patients. | low serum paraoxonase (pon) activity is thought to be a risk factor for the development of atherosclerosis. the present study was designed to evaluate pon1 activity and its relationship with preatherosclerotic markers such as lipid peroxidation and insulin resistance in hyperthyroid patients before and after propylthiouracil (ptu) treatment and in subjects with iatrogenic subclinical hyperthyroidism. | 2004 | 15473886 |
| developmental changes of thyroid hormones in the fathead minnow, pimephales promelas. | the fathead minnow is widely used in ecotoxicological studies and such investigations have begun to focus on potential disruption of the thyroid axis. however, normal levels of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) and their developmental patterns are unknown. to provide these baseline data, radioimmunoassays were developed and validated for analysis of t4 and t3 after extraction from plasma or whole fish. female fish showed consistently higher plasma levels of t4 than male fish. analy ... | 2004 | 15474536 |
| histone deacetylase 1 mrna expression in lung cancer. | histone deacetylases (hdacs) play a crucial role in tumorigenesis, however, the expression status of hdacs in lung cancer tissues has not been reported. we have investigated that hidac 1 mrna levels and other clinico-pathological data, including mta 1 mrna expression in lung cancer. the study included 102 lung cancer cases. the hdac1 mrna levels were quantified by real time reverse transcription-polymerase chain reaction (rt-pcr) using lightcycler (roche molecular biochemicals, mannheim, germany ... | 2004 | 15474665 |
| delayed spinal cord injury following electrical burns: a 7-year experience. | although delayed spinal cord injury following high-voltage electrical burn is not a life-threatening sequelae, complete recovery is not the rule and the morbidity is high. in this study, we conducted a detailed analysis of clinical characteristics, radiographic findings and clinical outcomes in 13 patients with delayed spinal cord injury following electrical burns. the following features were notable. in 11 patients whose entry sites were the head and neck area, paraplegia was detected in cases ... | 2004 | 15475144 |
| chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment. | the purpose of this research was to identify factors predicting response to preoperative chemotherapy. | 2004 | 15475452 |
| interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. | proinflammatory cytokines are involved in the pathogenesis of non-thyroidal illness (nti), as shown by studies with il-6-/- and il-12-/- mice. interleukin (il)-6 changes peripheral thyroid hormone metabolism, and il-12 seems to be involved in the regulation of the central part of the hypothalamic-pituitary-thyroid (hpt) axis during illness. il-18 is a proinflammatory cytokine which shares important biological properties with il-12, such as interferon (ifn)-gamma-inducing activity. | 2004 | 15476451 |
| phage-induced change in the stability of mrnas. | the stability of mrna in escherichia coli cells changed after phage t4 infection. stable e. coli mrnas such as lpp and ompa were drastically destabilized immediately after infection. in contrast, t4 phage soc mrna that had been unstable before infection became stabilized after infection. the host rnases e and g both contributed to the destabilization of these mrnas. accordingly, these rnases may alter their target rnas before and after infection. an rna chaperon, hfq, and polyadenylation at 3' e ... | 2004 | 15476881 |
| acanthamoeba keratitis in non-contact lens wearers in india: dna typing-based validation and a simple detection assay. | to establish that the protozoan acanthamoeba is one of the causative organisms associated with non-contact lens-related keratitis in the indian population and to develop a simple and sensitive diagnostic assay for clinical testing. | 2004 | 15477452 |
| urolithiasis associated with indinavir in a patient with spinal cord injury. | to report a case of indinavir-induced urolithiasis, and the greater risk of this occurrence in individuals with spinal cord injury (sci) who require fluid restriction for an intermittent catheterization program (icp). | 2004 | 15478531 |
| neonatal chemical hypothyroidism in nigeria. | to investigate the level of neonatal chemical hypothyroidism (nch), thyroid function was measured in the cord blood of 271 neonates in an area with a high prevalence of endemic goitre, bassa (n = 140), and a nonendemic area, jos (n = 131), in plateau state, nigeria. nch was defined as t4 < 40 nmol/l and tsh > 49 mu/l and borderline compensated nch as t4 31-50 nmol/l and tsh 41-49 mu/l. nch was detected in 16.4% of neonates in bassa and in 3.8% in jos. borderline compensated nch was detected in a ... | 2004 | 15479573 |
| vertebral wedging characteristic changes in scoliotic spines. | a morphometric analysis of vertebral wedging in vertebrae from scoliotic specimens. | 2004 | 15480123 |
| long term changes in serum t4, t3, and tsh in benign thyroid disease: proof of a narrow individual variation. | the diagnosis of abnormalities of thyroid function is generally based on the measurement of thyroid hormones and tsh in blood. the recommended reference ranges for serum t4 and t3 as well as tsh are quite wide as the result of large differences in thyroid function tests in healthy persons. it has been proven that the individual variation within an individual is small, compared with the variation between individuals. we investigated long term variations of these parameters in patients with and wi ... | 2004 | 15480504 |
| isolation and characterization of a cellulolytic geobacillus thermoleovorans t4 strain from sugar refinery wastewater. | a novel, cellulolytic, bacterial thermophilic strain, t4, was isolated from sugar refinery wastewater in southern taiwan. this isolate, a gram-negative, motile, aerobically growing sporulating rod, can secrete thermostable endocellulase (endo-1,4-beta-d-glucanase, ec 3.2.1.4) and hydrolyze carboxymethylcellulose (cmc), phosphoric acid-swollen cellulose, avicel, filter paper, and salicin. when strain t4 was grown in cmc medium, the cellulolytic enzyme activity in culture supernatants was stable u ... | 2004 | 15480864 |
| free thyroxine measured with equilibrium dialysis and nine immunoassays decreases in late pregnancy. | we measured free thyroxine in sera from 29 women in the ninth month of pregnancy. we used the reference method, equilibrium dialysis, and nine immunoassays. the bias between immunoassay and dialysis results was insignificant or modest. with all methods, the results were in the lower part of the non-pregnant female reference interval or below the lower limit of this interval: 10 results with the equilibrium dialysis assay and from 4 to 18 results with the nine immunoassays. method-specific refere ... | 2004 | 15481634 |
| case report: spontaneous spinal epidural haematoma during pregnancy: case report and review of the literature. | spontaneous epidural haematoma is rare in pregnancy and only five cases have been reported. we present a case of a 31-year-old female g2p1 who at 32 weeks of gestation developed progressive ascending paralysis and numbness to a level of approximately t4. an urgent mri of the spine was performed, which demonstrated a posterior epidural lesion at t1-t4 level. the lesion showed signal changes consistent with an epidural haematoma in the hyperacute stage. an emergency cesarean section was performed ... | 2004 | 15483004 |
| [factors associated with postoperative mortality following gastric adenocarcinoma surgery at the edgardo rebagliati martins hospital]. | this study is a retrospective, descriptive and observational evaluation aimed at defining the factors associated with postoperative mortality due to gastric adenocarcinoma and evaluating postoperative morbidity at the edgardo rebagliati martins hospital. | 2004 | 15483682 |
| performance of mouse lines divergently selected for heat loss when exposed to different environmental temperatures. i. reproductive performance, pup survival, and metabolic hormones. | mouse populations differing in metabolic rate have been developed through selection for high (mh) and low (ml) heat loss, along with the unselected controls (mc). objectives of the study were to compare the mh, ml, and mc lines for reproductive performance, pup survival, and metabolic hormones when reared at 12, 22, and 31 degrees c, and to search for line x environment interactions. conception and litter size were recorded on the parent generation mice introduced to the environments at 11 wk of ... | 2004 | 15484937 |
| effect of se on selenoprotein activity and thyroid hormone metabolism in beef and dairy cows and calves. | although se is essential for antioxidant and thyroid hormone function, factors influencing its requirement are not well understood. a survey and two experiments were conducted to determine the influence of cattle breed and age on selenoprotein activity and the effect of maternal se supplementation on cow and calf selenoprotein activity and neonatal thyroid hormone production. in our survey, four cowherds of different ages representing three breeds were bled to determine the influence of breed an ... | 2004 | 15484952 |
| the sequences and activities of regb endoribonucleases of t4-related bacteriophages. | the regb endoribonuclease encoded by bacteriophage t4 is a unique sequence-specific nuclease that cleaves in the middle of ggag or, in a few cases, ggau tetranucleotides, preferentially those found in the shine-dalgarno regions of early phage mrnas. in this study, we examined the primary structures and functional properties of regb ribonucleases encoded by t4-related bacteriophages. we show that all but one of 36 phages tested harbor the regb gene homologues and the similar signals for transcrip ... | 2004 | 15486207 |
| [recurrent micro-satellite stable colonic cancer: prolonged survival of 16 years without adjuvant therapy]. | long-term survival in malignant disease is often linked to intensified therapeutic interventions. we report the case of a colonic cancer in a 78 years old female patient, who underwent her first operation in 1987 for a symptomatic t4 carcinoma. since then, the patient has always denied any form of follow-up examination and adjuvant therapy. recently, she has undergone her fourth operation, which for the first time demonstrated peritoneal carcinosis, and is still in very good health.clinical expe ... | 2004 | 15486798 |
| extending low-dose epidural analgesia for emergency caesarean section using ropivacaine 0.75%. | we compared ropivacaine 0.75% and bupivacaine 0.5% for extending low-dose epidural analgesia for emergency caesarean section, using a prospective double-blind randomised controlled trial design. the trial was halted after 45 patients were studied (23 ropivacaine; 22 bupivacaine) because bupivacaine was replaced by levobupivacaine in our unit. time to reach t4 for loss of cold sensation was similar in both groups, although analgesic supplementation was required less often in the ropivacaine group ... | 2004 | 15488058 |
| lactobacillus plantarum bacteriophage lp65: a new member of the spo1-like genus of the family myoviridae. | the virulent lactobacillus plantarum myophage lp65 was isolated from industrial meat fermentation. tail contraction led to reorganization of the tail sheath and the baseplate; a tail tube was extruded. in ultrathin section the phage adsorbed via its baseplate to the exterior of the cell, while the tail tube tunneled through the thick bacterial cell wall. convoluted membrane structures were induced in the infected cell. progeny phage was detected 100 min postinfection, and lysis occurred after ex ... | 2004 | 15489418 |
| moda and modb, two adp-ribosyltransferases encoded by bacteriophage t4: catalytic properties and mutation analysis. | bacteriophage t4 encodes three adp-ribosyltransferases, alt, moda, and modb. these enzymes participate in the regulation of the t4 replication cycle by adp-ribosylating a defined set of host proteins. in order to obtain a better understanding of the phage-host interactions and their consequences for regulating the t4 replication cycle, we studied cloning, overexpression, and characterization of purified moda and modb enzymes. site-directed mutagenesis confirmed that amino acids, as deduced from ... | 2004 | 15489438 |
| thyroid hormone binding protein abnormalities in patients referred for thyroid disorders. | thyroid hormone binding protein (thbp) abnormalities are the major cause of discordance in commonly performed total thyroxine (t4) and thyrotropin (tsh) estimations, though these do not interfere with thyroid hormone action. determination of such abnormalities in patients showing discordant thyroid function tests (tfts) is diagnostically important as it eliminates equivocal assessment of thyroid function and treatment especially where proper methodology for free t4 (ft4) estimation is not availa ... | 2004 | 15489553 |
| clinical analysis of thyroid cancer in adult patients exposed to ionizing radiation due to the chernobyl nuclear accident: 5-year comparative investigations based on the results of surgical treatment. | the aim of study was to compare clinical and pathologic findings of surgically removed thyroid tumors in adults with or without history of irradiation due to the chernobyl accident. from 1990 to 2003, 2363 adults with no evidence of radiation influence in their history (group a) have undergone operation for thyroid nodules. during the same period, 311 patients (born before 1969) with strict evidence of chernobyl irradiation also underwent operation (group b). both groups were similar in age, sex ... | 2004 | 15490064 |
| prognostic factors of maxillary sinus malignancies. | analysis of a series of tumors of the maxillary sinus show contradictory outcome data. the purpose of this article was to study the prognostic factors that may have implications for patient management. | 2004 | 15490570 |
| genotypic diversity of oral actinomyces naeslundii genospecies 1 and 2 in caries-active preschool children. | a total of 991 isolates of actinomyces naeslundii were obtained from sound approximal tooth sites in either caries-active (n = 35) or caries-free (n = 20) preschool children. from this group of isolates, 101 strains were chosen to study the genotypic diversity of a. naeslundii genospecies 1 (n = 30), catalase-positive (n = 30), and catalase-negative genospecies 2 (n = 41). polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp), with a pair of primers targeting the 16s ribo ... | 2004 | 15491462 |
| local recurrence after radical cystectomy for invasive bladder cancer: an analysis of predictive factors. | to examine which clinicopathologic parameters predict clinically detectable local recurrence after radical cystectomy. local recurrence after radical cystectomy for invasive bladder cancer was infrequently observed until 20 years ago because of the lack of adequate diagnostic tools. the recent development and use of pelvic computed tomography has allowed us to detect local recurrence more precisely. however, only a few studies have investigated the rate and pattern of local recurrence in the com ... | 2004 | 15491713 |
| association of nucleophosmin/b23 mrna expression with clinical outcome in patients with bladder carcinoma. | to determine whether nucleophosmin/b23 mrna expression in bladder carcinoma predicts recurrence, progression, and survival. | 2004 | 15491744 |
| synthesis and properties of monodisperse oligofluorene-functionalized truxenes: highly fluorescent star-shaped architectures. | this paper describes the strategy toward novel monodisperse, well-defined, star-shaped oligofluorenes with a central truxene core and from monofluorene to quaterfluorene arms. introduction of solubilizing n-hexyl groups at both fluorene and truxene moieties results in highly soluble, intrinsically two-dimensional nanosized macromolecules t1-t4. the radius for the largest oligomer of ca. 3.9 nm represents one of the largest known star-shaped conjugated systems. cyclic voltammetry experiments reve ... | 2004 | 15493927 |
| analysis of gaa/ttc dna triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry. | the formation of a gaa/ttc dna triplex has been implicated in friedreich's ataxia. the destabilization of gaa/ttc dna triplexes either by ph or by binding to appropriate ligands was analyzed by nuclear magnetic resonance (nmr) and positive-ion electrospray mass spectrometry. the triplexes and duplexes were identified by changes in the nmr chemical shifts of h8, h1, h4, 15n7, and 15n4. the lowest ph at which the duplex is detectable depends upon the overall stability and the relative number of ho ... | 2004 | 15494127 |
| how an rna ligase discriminates rna versus dna damage. | t4 rna ligase 2 (rnl2) exemplifies a family of rna-joining enzymes that includes protozoan rna-editing ligases. rnl2 efficiently seals 3'-oh/5'-po4 rna nicks in either a duplex rna or an rna:dna hybrid but cannot seal dna nicks. rna specificity arises from a requirement for at least two ribonucleotides immediately flanking the 3'-oh of the nick; the rest of the nicked duplex can be replaced by dna. the terminal 2'-oh at the nick is important for the attack of the 3'-oh on the 5'-adenylated stran ... | 2004 | 15494308 |
| preoperative versus postoperative chemoradiotherapy for rectal cancer. | postoperative chemoradiotherapy is the recommended standard therapy for patients with locally advanced rectal cancer. in recent years, encouraging results with preoperative radiotherapy have been reported. we compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer. | 2004 | 15496622 |
| ["euthanasia"--victims and test subjects. the fate of diseased, disabled children in berlin during world war ii]. | this article shows, through a study of the berlin-brandenburg region, that children and juveniles who were subjected to the killings of diseased and disabled, or mentally retarded, persons during the third reich did not only fall victim to the operations of the "reichsausschuss" ("reich commission for registration of severe disorders in childhood"). many were also included in the gas chamber killings of the "t4"-action and in various decentralized killing actions. furthermore, the co-operation o ... | 2004 | 15497481 |
| electrographic imaging of recognition memory in 34-38 week gestation intrauterine growth restricted newborns. | electrophysiological imaging of recognition memory using event-related potentials (erps) in intrauterine growth-restricted (iugr) newborns allows assessment of recognition memory before the onset of multiple confounding variables. animal models that reproduce the physiologic components associated with iugr have demonstrated adverse effects on the hippocampus, a structure that is essential to normal memory processing. previous electrophysiologic studies have demonstrated shortened auditory-evoked ... | 2004 | 15498545 |
| d(g3t4g4) forms unusual dimeric g-quadruplex structure with the same general fold in the presence of k+, na+ or nh4+ ions. | we have recently communicated that dna oligonucleotide d(g(3)t(4)g(4)) forms a dimeric g-quadruplex in the presence of k(+) ions [j. am. chem. soc.2003, 125, 7866-7871]. the high-resolution nmr structure of d(g(3)t(4)g(4))(2) g-quadruplex exhibits g-quadruplex core consisting of three stacked g-quartets. the two overhanging g3 and g11 residues are located at the opposite sides of the end g-quartets and are not involved in g-quartet formation. d(g(3)t(4)g(4))(2) g-quadruplex represents the first ... | 2004 | 15498650 |
| [familial generalized thyroid hormone resistance. report of one case]. | thyroid hormone resistance is a rare autosomal dominant disease associated, in more than 90% of cases, to mutations in the beta thyroid hormone receptor. we report a 23 years old male that consulted for a psychiatric condition. clinically, the patient was euthyroid in spite of high total and free t4 and t3 concentrations, while tsh remained normal. also, tsh showed a five fold increase under trh stimulation. the mother and one of his brothers had the same pattern of abnormal serum thyroid hormon ... | 2004 | 15543767 |
| bioenergetic remodeling of heart mitochondria by thyroid hormone. | changes in thyroid status are associated with profound alterations in biochemical and physiological functioning of cardiac muscle impacting metabolic rate, contractility and structural hypertrophy. using an in vivo model of chronic treatment with thyroid hormone (t4, 0.3 mg/kg/day), we evaluated how mitochondria are regulated in response to t4, and assessed the relationship of t4-induced mitochondrial biogenesis and bioenergetics to overall cardiac hypertrophy. the role of thyroid hormone in car ... | 2004 | 15543939 |
| foldon, the natural trimerization domain of t4 fibritin, dissociates into a monomeric a-state form containing a stable beta-hairpin: atomic details of trimer dissociation and local beta-hairpin stability from residual dipolar couplings. | the c-terminal domain of t4 fibritin (foldon) is obligatory for the formation of the fibritin trimer structure and can be used as an artificial trimerization domain. its native structure consists of a trimeric beta-hairpin propeller. at low ph, the foldon trimer disintegrates into a monomeric (a-state) form that has similar properties as that of an early intermediate of the trimer folding pathway. the formation of this a-state monomer from the trimer, its structure, thermodynamic stability, equi ... | 2004 | 15544812 |
| sentinel lymph node metastases detected by immunohistochemistry only do not mandate complete axillary lymph node dissection in breast cancer. | the significance of breast cancer sentinel lymph node (sln) metastases detected only by immunohistochemistry staining (ihc) remains poorly understood. this study attempted to quantify the risk of non-sln metastases. | 2004 | 15545503 |
| erythrocyte osmotic fragility and oxidative stress in experimental hypothyroidism. | the present study was planned to explain the relation between erythrocyte osmotic fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. twenty-four spraque dawley type female rats were divided into two, as control (n = 12) and experimental (n = 12), groups weighing between 160 and 200 g. the experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). control group animals ... | 2004 | 15545699 |
| thyrotoxicosis presenting as hypogonadism: a case of central hyperthyroidism. | herein, we present a case of central thyrotoxicosis with well-documented serial therapeutic interventions. thyroid-stimulating hormone (tsh)-secreting pituitary tumors represent a rare cause of hyperthyroidism. it is being diagnosed more frequently with the third-generation tsh assay. many conditions can produce normal or elevated tsh levels in combination with elevated thyroid hormone levels. the differential diagnosis includes resistance to thyroid hormone (rth, refetoff's syndrome), assay int ... | 2004 | 15545848 |
| regional anesthesia as an alternative to general anesthesia for abdominal surgery in patients with severe pulmonary impairment. | it is known that smokers and patients with chronic obstructive pulmonary disease (copd) experience a higher rate of pulmonary-related complications following abdominal surgery. the impact of anesthetic technique (regional [ra] versus general [ga] versus combination of both) on the complication rate has not been established. this study examined the outcomes of abdominal surgery performed using ra (epidural or continuous spinal) as the sole anesthetic technique in patients with severe pulmonary im ... | 2004 | 15546579 |
| a self-splicing group i intron in dna polymerase genes of t7-like bacteriophages. | group i introns are inserted into genes of a wide variety of bacteriophages of gram-positive bacteria. however, among the phages of enteric and other gram-negative proteobacteria, introns have been encountered only in phage t4 and several of its close relatives. here we report the insertion of a self-splicing group i intron in the coding sequence of the dna polymerase genes of phii and w31, phages that are closely related to t7. the introns belong to subgroup ia2 and both contain an open reading ... | 2004 | 15547290 |
| ropivacaine produces sensory blockade in the lumbar sacral region more frequently than mepivacaine in lower thoracic epidural anesthesia. | the first sacral nerve has the largest diameter among the spinal nerves and is resistant to local anesthetics. ropivacaine is a newly developed local anesthetic. there is a possibility that a difference in chemical properties between ropivacaine and other local anesthetics produces a difference in the blockade of the s1 dermatome by lower thoracic epidural anesthesia. mepivacaine, 2%, is frequently used for epidural anesthesia and produces a level of blockade similar to that of bupivacaine, 0.5% ... | 2004 | 15549466 |
| noninvasive detection of alterations in chromosome numbers in urinary bladder cancer cells, using fluorescence in situ hybridization. | bladder cancers have a high potential for recurrence and sometimes become invasive even in superficial cases. in this process, gene mutations in tumor suppressor genes such as p53, on chromosome 17, or p16, on chromosome 9, are thought to be important. in order to investigate whether the detection of alterations in chromosome number might be used as an alternative to invasive techniques for the assessment of clinical bladder cancer, fluorescence in situ hybridization (fish) was employed to analy ... | 2004 | 15549587 |
| merkel cell carcinoma in a malignant pleural effusion: case report. | background: merkel cell (neuroendocrine) carcinoma is a small round blue cell malignant neoplasm that primarily presents in the skin. the diagnosis of merkel cell carcinoma in a pleural fluid is challenging because of the morphological similarity to many other malignant neoplasms. immunohistochemical stains can be essential to establish the diagnosis of merkel cell carcinoma. case presentation: a 77 year-old woman presented with a mass in her right buttock thought clinically to be a boil or seba ... | 2004 | 15550173 |
| fatal intra-alveolar hemorrhage after rituximab in a patient with non-hodgkin lymphoma. | a 65-year-old male developed progressive dry cough and digital clubbing after starting rituximab-chop chemotherapy for non-hodgkin lymphoma. a lung biopsy showed loose non-necrotic granulomas in a background of mild fibrosis and rare eosinophils, compatible with a drug-induced hypersensitivity pneumonia. associated manifestations of this hypersensitivity reaction were a high eosinophil count, elevated serum levels of immunoglobulin e, and a skin rash consistent with pigmented purpuric dermatitis ... | 2004 | 15512824 |
| the genome of bacteriophage t4: an archeological dig. | 2004 | 15514035 | |
| prognostic indications for hürthle cell cancer. | hürthle cell carcinoma (hcc) has been reported to have variable clinical behavior. the objective of this study was to determine the important prognostic factors in patients with hcc. it was a retrospective investigation of 33 patients with hcc treated in our institution from 1976 to 2002. the average age of our 33 patients with hcc was 55.2 years (range 20-82 years; 23 women, 10 men). fifteen patients (45.5%) presented with a t2 tumor, 7 (21.2%) with a t3 tumor, and 8 (24.2%) with a t4 tumor; th ... | 2004 | 15517492 |
| respiratory symptoms and bronchoalveolar lavage abnormalities in molybdenum exposed workers. | to detect an adverse effect of chronic inhalative molybdenum trioxide (moo3) exposure in a group of symptomatic moo3 exposed workers. | 2004 | 15518088 |
| ecto-atpases of clinical and non-clinical isolates of acanthamoeba. | acanthamoeba are opportunistic protozoan parasites that can cause fatal granulomatous amoebic encephalitis and eye keratitis, however the pathogenic mechanisms of acanthamoeba remain unclear. in this study, we described the ability of live acanthamoeba to hydrolyse extracellular atp. both clinical and non-clinical isolates belonging to genotypes, t1, t2, t3, t4 and t7 exhibited ecto-atpase activities in vitro. using non-denaturing polyacrylamide gel electrophoresis, ecto-atpases were further cha ... | 2004 | 15519044 |
| multi-slice ct of thyroid nodules: comparison with ultrasonography. | to evaluate the usefulness of multi-slice computed tomography (msct) in comparison with ultrasonography (us) for the differentiation of benign from malignant thyroid nodules and the evaluation of tumor extension. | 2004 | 15553016 |
| [effects of repeated intraperitoneal cddp chemotherapy for the prevention of t3 and t4 gastric cancer]. | we studied the significance of repeated intraperitoneal cddp administration, as adjuvant chemotherapy, for the prevention of t3 and t4 gastric cancer. fifty-two patients who had been operated as curability b were divided into the following two groups, and the data on survival rate, median survival time and interval of "free of recurrence" were accumulated and analyzed. group a consisted of nineteen patients treated with intraperitoneal cddp administration and oral anticancer drugs. group b were ... | 2004 | 15553694 |
| [a case of scirrhous carcinoma of the stomach with malignant pleural and peritoneal carcinomatosis responding to the local administration of docetaxel (txt)]. | we report the case of a 34-year-old woman who underwent total gastrectomy for scirrhous carcinoma in the stomach (t4, n0, h0, cy1, p1, stage iv). despite adjuvant chemotherapy with ts-1 and/or cddp, ascites caused by peritoneal carcinomatosis increased four months after gastrectomy. therefore, intraperitoneal administration of docetaxel (txt) at a dosage of 45 mg/m2 was applied. this therapy successfully maintained her good quality of life by inhibiting the increase of ascites without any severe ... | 2004 | 15553736 |
| [study on relationship among thyroid hormone relativity and syndrome differentiation-types of tcm in patients with congestive heart failure]. | to study the relationship between the tcm syndrome differentiation-types of congestive heart failure (chf) and thyroid hormones, including triiodothyronine (t3), thyroxine (t4) and thyroid stimulating hormone (tsh), and atrial natriuretic peptide (anp), as well as cardiac function parameters, including left ventricular ejection fraction (lvef), mean velocity of circumferentid fiber shortening (mvcf) and a peak/e peak (a/e). | 2004 | 15553815 |
| [molecular enzymology of phage t4 dam dna-methyltransferase]. | the review reflects results of studies on the molecular mechanism of phage t4 dam dna-methyltransferase action. the enzyme (t4dam) catalyzes methyl group transfer from s-adenosyl-l-methionine (adomet) to n6-adenine position in the palindromic recognition sequence gatc (ec 2.1.1.72). the enzyme subunit structure, substrate-binding and kinetic parameters for a wide range of native and modified oligonucleotide duplexes, as well as steady-state reaction kinetic scheme, included t4dam isomerization t ... | 2004 | 15554189 |
| [plasmid spectra and phagotypes of escherichia coli strains isolated from patients with large intestine tumours]. | the work deals with connection between plasmid spectra and phagotypes of escherichia coli strains isolated from patients with tumours in large intestine. it has been established that 70 % of this bacterium isolates from the normal tissue, intestine lumen and tumours are characterized by multiple content of plasmids. sometimes large endogenic plasmids are accompanied by the closed ring dna with discrete sizes: 3.2; 3.8 and 4.0 kb. other extrachromosomal factors have the size of 63-119 kb and are ... | 2004 | 15554295 |
| effects of vitamin supplementation on pcb (aroclor 1254)-induced changes in ventral prostatic androgen and estrogen receptors. | the objective of this study was to determine the impact of the polychlorinated biphenyl (pcb) aroclor 1254 and vitamin c and e on ventral prostatic testosterone and estradiol receptor concentration. a group of 30 rats were treated with aroclor 1254 [2 mg/kg body weight (bwt) /day/ip] for 30 days; 10 rats were treated as aroclor 1254 control. the remaining 20 rats were subdivided into the following two subgroups of 10 animals each. one group was given vitamin c (500 mg/kg bwt/day/oral) for 10 day ... | 2004 | 15554362 |
| effect of thyroid function on ldl oxidation in hypothyroidism and hyperthyroidism. | oxidized low-density lipoproteins (ldl) are highly suspected of initiating the atherosclerosis process. hypothyroidism is frequently associated with hypercholesterolemia and carries increased risk for atherosclerosis. in contrast to hypothyroidism, hyperthyroidism is not associated with increased ldl cholesterol, but is associated with increased oxidized ldl. this study was designed to evaluate the changes in ldl oxidation in subjects with hypothyroidism or hyperthyroidism, and to reveal the eff ... | 2004 | 15554363 |
| role of thyroid hormone during early brain development. | the present comments are restricted to the role of maternal thyroid hormone on early brain development, and are based mostly on information presently available for the human fetal brain. it emphasizes that maternal hypothyroxinemia - defined as thyroxine (t4) concentrations that are low for the stage of pregnancy - is potentially damaging for neurodevelopment of the fetus throughout pregnancy, but especially so before midgestation, as the mother is then the only source of t4 for the developing b ... | 2004 | 15554884 |
| surgical issues in rectal cancer: a 2004 update. | rectal cancer is a major health concern in the united states, with an estimated 40,570 new cases diagnosed in 2004. there are 4 major goals in the treatment of a patient with rectal cancer: local control; long-term survival; preservation of anal sphincter, bladder, and sexual function; and maintenance or improvement in quality of life. recent advances have been made in preoperative staging, local and radical surgical therapy, the importance of distal and circumferential resection margins, postop ... | 2004 | 15555204 |
| bone mineral density during maintenance treatment with supraphysiological doses of levothyroxine in affective disorders: a longitudinal study. | this prospective study was designed to determine whether patients with prophylaxis-resistant affective disorders, receiving adjunctive maintenance therapy with supraphysiological doses of levothyroxine (l-t4), show evidence of accelerated bone loss compared to the reference population database. | 2004 | 15555712 |
| adenocarcinoma of the gastric cardia: what is the optimal surgical approach? | the incidence of adenocarcinoma of the gastric cardia is rising in western countries. this study evaluates prognostic factors associated with surgical management of this cancer. | 2004 | 15555971 |
| the prognostic relevance of fascin expression in human gastric carcinoma. | fascin, an actin-bundling protein that is found in membrane ruffles, microspikes, and stress fibers, induces membrane protrusions and increases cell motility in various transformed cells. the expression of fascin in epithelial neoplasms has been described only recently, and its role in gastric cancer is still unknown. | 2004 | 15557788 |
| overexpression of sparc gene in human gastric carcinoma and its clinic-pathologic significance. | gastric cancer is the second most common cancer in the world and the fifth leading cause of cancer-related death in taiwan. to improve the survival of gastric cancer patients, biomarkers for early detection and effective anticancer therapy are required. an essential first step is to profile gene expression in gastric cancer and identify genes that are aberrantly expressed, and to do this cdna microarrays were performed. the clinic-pathologic correlation and prognostic significance of the aberran ... | 2004 | 15558074 |
| [effects of inorganic nitrates on thyroid gland activity and morphology in female rats]. | the present study was undertaken to determine the effects of intake of inorganic nitrates in drinking water on thyroid gland activity and morphology in female rats. during 5 months of treatment, nitrates 50, 150 and 500 mg/l induced a significant dose-dependent decrease in bodyweight gain, compared with the control rats. at the end of the experiment, nitrates 150 and 500 mg/l induced hypertrophy of the thyroid gland, accompanied by an increase in the size of the thyroid follicles and hyposecreti ... | 2004 | 15559551 |
| ribonuclease activity of the peptides with alternating arginine and leucine residues conjugated to tetrathymidilate. | rna cleaving conjugates have been prepared by attachment of oligodeoxyribonucleotide tttt to peptides containing arginine, leucine, proline and serine residues. the highest activity was displayed by the conjugates containing peptides with alternating arginine and leucine residues (lr)4g-amide. ribonuclease activity of the conjugates pep-t4 decreases in the order t4-(lr)4g > t4-(lr)2g > t4-(llrr)2g > t4-(lr)2prlrg > s2r3-hmda-t4 > or = r5 double dagger (lr)3. according to cd spectra, the free pep ... | 2004 | 15560077 |