Publications

the conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type i iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.	triiodothyronine (t3) is the main active hormone, which is derived 20% from the thyroid gland and 80% from peripheral tissues. thyroxin--5' deiodinases play a leading role in maintaining appropriate t3 concentrations in the different cells and organs: including the lung. the deiodinases present in pneumocytes were found to be localised in endoplasmatic reticulum. aims of this study were: 1. to estimate activities of type i and type ii iodothyronine 5' deiodinases (di, dii) in two histological ty ...	2003	14635503
tumour cell and stromal features in metastatic and non-metastatic non-small cell lung carcinomas.	tumour cell behaviour depends on the interactions between nuclear genetic changes in the malignant cells and a stroma favourable for growth, invasion and metastasis. to evaluate such interactions, we studied the relationship between tumour cell and stromal features for proliferative factors, p53, microvessel density and metalloproteinases, controlled for the extent of the primary lesion (t1 to t4), in early (non-metastatic) and late (metastatic) non-small cell lung carcinomas (nsclc).	2003	14636269
age-dependent changes in the response of the stomach to thyroidal signaling in developmentally arrested larval summer flounder.	thyroid-dependent stomach development occurs between approximately 35 and 50 days post-hatch (dph) in laboratory-reared summer flounder larvae. the process can be blocked by thiourea (tu), and tu effects are reversed by exogenous thyroxine (t4). to establish whether a window of sensitivity exists for t4-dependent gastric development, we arrested development of larvae with 0.39 mm tu given from 26 to 61dph, and measured weekly the developmental response of the stomach to 13 nm t4 for 0, 2, or 7 d ...	2003	14636630
blocking the t4 lysis inhibition phenotype.	nonlysogenic escherichia coli k cells exhibit a delay in lysis when infected by t4rii phage termed lysis inhibition (lin). e. coli k cells expressing lambda rexb from either a prophage defective for rexa, or a multicopy plasmid supported t4rii infection, but prevented the establishment of lin. in addition, e. coli null mutations in either the periplasmic "tail-specific protease" tsp, or the 10sa rna ssra, completely blocked the establishment of lin following t4 infections. the expression of rexb ...	2003	14637004
deiodinating activity in the brown adipose tissue of rats following short cold exposure after strenuous exercise.	interscapular brown adipose tissue (ibat) activity is controlled by the sympathetic nervous system, and factors that influence thermogenesis appear to act centrally to modify the sympathetic outflow to ibat. cold exposure produces a rise in ibat temperature as a result of the increase in sympathetic outflow to ibat. this is associated with an increased thyroid activity. 3,5,3'-triiodothyronine (t3) and t4 levels increase during strenuous exercise, and, at the end of the exercise bout, a decrease ...	2003	14637241
afferent pathways and responses of t3-t4 spinal neurons to cervical and thoracic esophageal distensions in rats.	the purposes of this study were to (1) compare responses of t(3)-t(4) spinal neurons to thoracic and cervical esophageal distension (ted, ced) and (2) determine afferent pathways for esophageal input to these neurons. extracellular potentials of single superficial and deeper t(3)-t(4) neurons were recorded in pentobarbital anesthetized male rats. graded ted or ced was produced by water inflation (0.1-0.5 ml) of a latex balloon. ted changed activity of 121/432 (28%) neurons (114 were excited); ce ...	2003	14638308
cervical and high thoracic ligamentum flavum frequently fails to fuse in the midline.	cervical and high thoracic epidural anesthesia and analgesia have gained increasing importance in the treatment of painful conditions and as components of anesthetics for cardiac and breast surgery. in contrast to the hanging-drop technique, the loss-of-resistance technique is thought to rely on the penetration of the ligamentum flavum. however, the exact morphology of the ligamentum flavum at different vertebral levels remains controversial. therefore, the aim of this study was to investigate t ...	2003	14639154
results of surgical treatment of t4 non-small cell lung cancer.	because of location and invasion of surrounding structures, the role of surgical treatment for t4 tumors remains unclear. extended resections carry a high mortality and should be restricted for selected patients. this study clarifies the selection process in non-small cell t4 tumors with invasion of the mediastinum, recurrent nerve, heart, great vessels, trachea, esophagus, vertebral body, and carina, or with malignant pleural effusion.	2003	14643822
is there a role for pre-operative contrast-enhanced magnetic resonance imaging for radical surgery in malignant pleural mesothelioma?	to assess the use of contrast-enhanced magnetic resonance imaging (cemri) in addition to computed tomography in the pre-operative assessment of patients for radical surgery in malignant pleural mesothelioma.	2003	14643823
clinical value of video-assisted thoracoscopy for preoperative staging of non-small cell lung cancer. a prospective study of 105 patients.	this study prospectively evaluated the usefulness of thoracoscopy for staging non-small cell lung cancer in 105 consecutive patients. a comparison was made of tnm stage grouping classification according to clinical disease, thoracoscopic data, and pathological findings. in 40 (38%) patients, thoracoscopy was unreliable for assessing extent of disease due to pleural symphysis. in 13 t1 clinical lesions, thoracoscopy was unreliable in 5, clinical and thoracoscopic staging concurred in 4, but 4 cas ...	2003	14644517
the effect of intraperitoneal melatonin supplementation on the release of thyroid hormones and testosterone in rats with hyperthyroid.	melatonin has a general inhibitory effect on the reproductive system and thyroid functions. testosterone secretion increases in parallel to thyroid hormones in hyperthyroidism. the aim of this study was to investigate the effects of melatonin application on total t3, t4 and testosterone in hyperthyroid rats.	2003	14647010
anal canal cancer treatment: practical limitations of routine prescription of concurrent chemotherapy and radiotherapy.	this study is an analysis of the criteria considered when prescribing concomitant chemotherapy and radiotherapy, as a routine treatment for patients with anal canal cancer, and related complications. between 1990 and 1996, 67 patients were treated at institut curie for invasive, nonmetastatic cancer of the anal canal. median age was 65 years (range, 35-90 years). tnm stage distribution was as follows: seven t1, 17 t2, 27 t3, 16 t4, and 22 n+ patients. a total of 29 patients (i.e., five t1/t2, an ...	2003	14647138
hmgi(y) gene expression in colorectal cancer: comparison with some histological typing, grading, and clinical staging.	we investigated hmgi(y) gene expression in 81 pairs of frozen samples obtained from colorectal carcinomas and adjacent normal colorectal mucosas and in four samples from colorectal mucosa from patients without neoplastic diseases. in this group, hmgi(y)-positive/-negative expression was compared with some histological features, grading, and clinical staging of neoplasms investigated to assess its potential role as a prognostic marker for colorectal cancer. expression of hmgi(y) gene was found in ...	2003	14666966
enduring challenge in the treatment of nonsmall cell lung cancer with clinical stage iiib: results of a trimodality approach.	stage iiib (t4/n3) non-small-cell lung cancer (nsclc) is considered an inoperable disease and treatment is an enduring challenge. surgery after induction therapy seems to improve locoregional control. we report the results of a phase ii prospective trimodality trial (chemotherapy and concomitant radiotherapy plus surgery) in patients with stage iiib nsclc.	2003	14667587
induction chemoradiotherapy and surgical resection for selected stage iiib non-small-cell lung cancer.	combination chemotherapy using an oral combination of uracil and tegafur (uft) plus cisplatin and concurrent thoracic radiotherapy is reported to have a high response rate and less toxicity for locally advanced non-small-cell lung cancer (nsclc) patients. we performed a phase ii trial using this chemoradiotherapy as an induction treatment.	2003	14667588
acute decrease in circulating t3 levels enhances, but does not normalise, the gh response to ghrp-6 plus ghrh in thyrotoxicosis.	in thyrotoxicosis there is an impaired gh response to ghrh, normal gh responsiveness to ghrp-6 and lack of synergistic gh response after simultaneous administration of both peptides. we have previously shown that the ghrh-induced gh release in these patients increases after an acute reduction of circulating t3 values with administration of iopanoic acid, a compound that inhibits peripheral conversion of t4 to t3. we have now studied the effect of a decrease in serum t3 levels on the gh response ...	2003	14669827
resistance to thyrotropin.	resistance to tsh is a syndrome of reduced sensitivity to a biologically active tsh molecule. subjects have elevated tsh levels but no goiter. however, thyroid hormone concentration may vary from normal to very high, depending on the severity of the resistance. individuals with very high tsh, low t4 and hypoplastic thyroid glands can be mistakenly diagnosed as having primary hypothyroidism due to a defective development of the thyroid gland. those with normal or slightly decreased t4 can be misd ...	2003	14669836
cerebral oximetry monitoring during carotid endarterectomy: effect of carotid clamping and shunting.	cerebral oximetry is a simple method of measuring regional cerebral oxygen saturation (rso(2)). one promising application is its use during carotid endarterectomy (cea) to help minimize the risk of perioperative stroke. the authors used the invos-4100 cerebral oximeter at several steps during cea to measure the effect of carotid clamping and shunting on rso(2). the authors prospectively evaluated 42 consecutive ceas in 40 patients. all had cea under general anesthesia with the routine use of a j ...	2003	14671695
[continuous epidural infusion of ropivacaine hydrochloride (naropin) during postoperative analgesia in cardiosurgical patients].	an efficiency and safety of continuous infusion of naropin in the epidural analgesia of 38 patients after coronary artery bypass grafting were demonstrated. a variation of combined anesthesia, which was elaborated at the russian research center of surgery of the russian academy of medical sciences and which comprises (as a basic component of anesthetic management) a high thoracal epidural block (t2-t4) by continuous infusion of a 2% solution of naropin at a velocity of 5 +/- 2 ml/h. anesthesia w ...	2003	14671915
patterns of recurrence after sentinel lymph node biopsy for cutaneous melanoma.	previous sentinel lymph node (sln) studies for cutaneous melanoma have shown that the sln accurately reflects the nodal status of the corresponding nodal basin. however, there are few long-term studies that describe recurrence site patterns, predictors for recurrence, and overall survival and disease-free survival after sln biopsy.	2003	14672778
treatment of palmar hyperhidrosis by endoscopic clipping of the upper part of the t4 sympathetic ganglion. preliminary results.	endoscopic thoracic sympathetic surgery is a safe and effective method of treating palmar hyperhidrosis. although hand dryness is the positive outcome of surgery, a residual amount of moisture in the hand is believed to improve the quality of life. reflex sweating is a well-recognized and annoying complication that surgeons endeavor to avoid. from may 1, 2002 to july 31, 2002, 52 patients suffering from palmar hyperhidrosis were operated on by means of endoscopic clipping of the upper part of th ...	2003	14673674
experience with limited endoscopic thoracic sympathetic block for hyperhidrosis and facial blushing.	endoscopic thoracic sympathetic block (esb) has recently become a popular modification of sympathetic surgery, as it offers the potential chance of reversibility. in order to reduce side effects such as compensatory sweating limited esb at the levels of the t2, t3 or t4 ganglia has been recommended (lin/telaranta classification). we present our experience and initial results with this technique. from 6/2001 to 2/2003, 184 esb procedures were performed in 94 patients. esb4 was carried out in 53 p ...	2003	14673675
microinvasive resectional sympathectomy using the harmonic scalpel. a more effective procedure with fewer side effects for treating essential hyperhidrosis of the hands, face or axillae.	compensatory sweating remains one of the most unpredictable and debilitating complications of sympathectomy for hyperhidrosis. there appears to be a significant difference in compensatory sweating rates seen between the different techniques utilized to treat hyperhidrosis. resectional techniques have historically resulted in excellent symptom relief with relatively low levels of severe post-op compensatory sweating. the advent of video-assisted approaches to the treatment of hyperhidrosis has le ...	2003	14673678
differential effects of surgical sympathetic block at the t2 and t4 level on vasoconstrictor function.	endoscopic sympathetic block (esb) is used as a treatment of excessive palmar sweating. in a prospective study we compared the effect of esb at the level of the second (t2) and fourth thoracic ganglion (t4) on vasoconstriction and sweating of the hands. sympathetic vasoconstriction was measured by computerassisted infrared thermography following ice water immersion of the hands in 22 hyperhidrosis patients before, two days and 3 months post op. in addition, palmar sweating before and 3 months po ...	2003	14673681
complications of gastrectomy following cpt-11-based neoadjuvant chemotherapy for gastric cancer.	potential benefits of neoadjuvant therapy for locally advanced gastric cancer include tumor downstaging and an increased r0 resection rate. potential disadvantages include increased surgical complications. this study assesses postoperative morbidity and mortality by comparing patients undergoing gastrectomy with and without neoadjuvant chemotherapy. from october 1998 to july 2002, a total of 34 patients with locally advanced gastric cancer were placed on a phase ii neoadjuvant chemotherapy proto ...	2003	14675711
cyclic gmp protein kinase activity is reduced in thyroxine-induced hypertrophic cardiac myocytes.	1. we tested the hypothesis that the cgmp-dependent protein kinase has major negative functional effects in cardiac myocytes and that the importance of this pathway is reduced in thyroxine (t4; 0.5 mg/kg per day for 16 days) hypertrophic myocytes. 2. using isolated ventricular myocytes from control (n = 7) and t4-treated (n = 9) rabbit hypertrophic hearts, myocyte shortening was studied with a video edge detector. oxygen consumption was measured using o2 electrodes. protein phosphorylation was m ...	2003	14678234
gastrectomy, peritonectomy, and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer.	gastric cancer disseminates by hematogenous, lymphatic, and transcoelomic routes. for maximal containment of the malignant process, perioperative intraperitoneal chemotherapy is necessary in two groups of patients in whom the primary cancer can be resected. those patients who have been resected for cure and have a high likelihood of microscopic residual disease require intraperitoneal chemotherapy. this includes all t3 and t4 patients, and patients with n2 nodes present. a series of randomized a ...	2003	14648781
preoperative chemoradiation for locally advanced rectal cancer: rationale, technique, and results of treatment.	over the past decade, 392 patients with stage ii and iii rectal cancer have been managed with preoperative chemoradiation and surgery at the m. d. anderson cancer center (mdacc). aggressive surgical techniques such as total mesorectal excision, proctectomy with coloanal anastamosis, and multivisceral excisions have been used. initial pelvic chemoradiation is also used in patients who present with metastases. preoperative chemoradiation followed by surgery has resulted in excellent sphincter pres ...	2003	14648785
the effect of thyroid hormones on blood insulin level and metabolic parameters in diabetic rats.	the effect of exogenous thyroid hormones on blood insulin and metabolic parameters in diabetic rats was investigated. three groups of rats were treated with streptozotocin (stz; 50 mg/kg b.w., intravenously) and one group receiving only saline served as control. beginning with the third day after stz treatment, until the last day before decapitation, i.e. for 11 days, two groups of diabetic rats were treated with t3 (50 microg/kg b.w., i.p.) or t4 (250 microg/kg b.w., i.p.). after two weeks, stz ...	2003	14649872
newborn screening for congenital hypothyroidism in khon kaen university hospital, the first three years, a preliminary report.	between january 2000 and december 2002, 9,558 of 10,868 live births at srinagarind hospital, khon kaen university, khon kaen, thailand, were screened for congenital hypothyroidism (ch). dried blood spot thyroid stimulating hormone (tsh) was collected at age 48 hours or older. the cut-off tsh level for recall test was > 25 mu/l. serum thyroxine (t4), free t4 and tsh were performed during the confirmatory test. six of 24 infants recalled for confirmatory thyroid function tests had abnormal tests. ...	2003	14650705
[amiodarone and thyroid dysfunction: a pending problem].	amiodarone is an antiarhytmic drug used in many clinical situations for its probed effect; it is also preferred in particular groups of patients (heart failure, post-ischemical) for its safe and its prognostic benefits. however, a substantial proportion of amiodarone treated patients develop either hypothyroidism or thyrotoxicosis. both abnormalities may occur in apparently normal glands or in glandes with pre-existed abnormalities. it may be difficult to recognize the dysfunction because of the ...	2003	14650817
[autoimmune phenomena during interferon-alpha therapy for hematopoietic disorders].	the development of various kinds of autoimmune disease as a result of interferon-alpha (ifn-alpha) therapy has been reported among chronic myeloproliferative disorders(cmpd) including chronic myeloid leukemia(cml). therefore, we investigated the frequency of autoimmune disorders in 33 patients with hematopoietic diseases treated with ifn-alpha in our department. thirty-three patients (12 females, 21 males) included cases of cml (n = 23), essential thrombocythemia (et) (n = 1), multiple myeloma ( ...	2003	14650958
esthesioneuroblastoma: endoscopic nasal and anterior craniotomy resection.	the objective was to illustrate the use of endoscopic techniques as an evolving surgical modality in excision of esthesioneuroblastoma. the authors advocate this method with excision with anterior craniotomy for removal of cribriform plate or anterior cranial fossa tumor extension.	2003	14660907
[mri staging of prostate cancer with the combined endorectal body phased-array coil and histologic correlation].	evaluation of the diagnostic value of the combined endorectal body-phased array technique regarding the staging of prostate cancers, especially in the differentiation between stages t2 and t3.	2003	14661137
[the role of spiral ct in the preoperative evaluation of malignant gastric neoplasms].	the purpose of this study was to evaluate the performance of spiral ct in preoperative staging in patients with gastric cancer.	2003	14661602
high-risk localised prostate cancer: multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy.	for patients with newly diagnosed prostate cancer, clinical tumour stage, gleason score of the diagnostic biopsy specimen and serum prostate-specific antigen (psa) level can be combined to identify a group of men at increased risk of treatment failure after radiotherapy or radical prostatectomy. for these high-risk, but still clinically localised prostate cancers, multimodal treatment strategies may result in improved cancer control outcomes. indeed, in the setting of clinical stage t3 - t4 tumo ...	2003	14661990
thyroid function studies in patients with cancer of the larynx: preliminary evaluation.	our goal was to evaluate thyroid function before and after surgery only or radiotherapy plus surgery for laryngeal neoplasms.	2003	14663443
development of severe complications caused by stent placement followed by definitive radiation therapy for t4 esophageal cancer.	esophageal stenting in previously irradiated patients is known to cause more severe complications than those in patients who were not irradiated. but there are few reports regarding the results of stent placement before radiation therapy. three patients with stage t4 esophageal cancer with direct invasion to the trachea and/or aorta underwent radiation therapy after stent placement. two of the three patients had received systemic chemotherapy before radiation therapy. fifty-one to 66 gy of radia ...	2003	14663644
total syntheses of amphidinolide t1, t3, t4, and t5.	a concise, flexible, and high yielding entry into the family of amphidinolide t macrolides, a series of cytotoxic natural products of marine origin, has been developed. all individual members, except amphidinolide t3 (3), derive from compound 39 as a common synthetic intermediate which is formed from three building blocks of similar size and complexity. the fragment coupling steps involve a highly diastereoselective sncl(4) mediated reaction of the furanosyl sulfone derivative 11 with the silyl ...	2003	14664598
combined t4 and t3 therapy--back to the drawing board.		2003	14665664
histogram analysis of computed tomography numbers of clinical t1 n0 m0 lung adenocarcinoma, with special reference to lymph node metastasis and tumor invasiveness.	to predict lymph node metastasis and tumor invasiveness in lung adenocarcinoma from computed tomography findings, we examined computed tomography number histograms of clinical t1 n0 m0 lung adenocarcinomas.	2003	14666037
preoperative chemotherapy for esophageal cancer with paclitaxel and carboplatin: results of a phase ii trial.	paclitaxel has one of the highest response rates when used as a single agent in patients with esophageal cancer. the combination of paclitaxel and carboplatin has been shown to be a well-tolerated and safe regimen in non-small cell lung cancer. the objective of this study was to determine the efficacy of preoperative paclitaxel and carboplatin in patients with carcinoma of the esophagus.	2003	14666040
cephalometric evaluation of the craniofacial complex in patients treated with an intraoral distraction osteogenesis device: a preliminary report.	the purpose of this pilot study was to evaluate cephalometrically the efficacy of an intraoral distraction osteogenesis device in treating patients with unilateral mandibular hypoplasia. six patients with hemifacial microsomia underwent unilateral mandibular distraction. posteroanterior and 45 degrees lateral oblique cephalograms were measured, and changes in maxillary width and height, occlusal height, ramus height, mandibular length, and chin position were quantified. measurements were taken p ...	2003	14666076
role of video-assisted thoracoscopic sympathectomy in the treatment of primary hyperhidrosis.	essential hyperhidrosis is a frequent disorder causing significant functional impairment. the advent and development of video-assisted thoracoscopic techniques now allows thoracic sympathectomy to be carried out precisely and safety with good results and minimal morbidity.	2003	14666290
the activity in the cns catecholaminergic systems covaries with thyroid hormone metabolism in humans.	do the cns monoaminergic (ma) systems regulate thyroid hormone metabolism in humans? in 23 unmedicated, male, violent offenders without signs of thyroid disease, we found positive correlations between the catecholaminergic csf metabolites hva and mhpg and the peripheral t3/t4 ratio (rho=0.55, p=0.010 and 0.51, p=0.018), indicating that increased activity in the brain ma systems, especially the dopaminergic, is associated with increased peripheral thyroid hormone activity.	2003	14666409
[effects of esmolol- and sodium nitroprusside-induced controlled hypotension on hepatocellular integrity in patients undergoing endonasal sinus surgery].	controlled hypotension (ch) is an established method to reduce intraoperative bleeding. the aim of the study was to investigate the influence of ch induced by sodium nitroprusside (sn) or esmolol on hepatocellular integrity.	2003	14666441
relationships between s-100 protein-positive cells and clinicopathological factors in patients with colorectal cancer.	an increased number of dendritic cells (dcs), as indicated by positive s-100 protein staining, has been shown to correlate with good prognosis in several malignancies. the clinicopathological significance of s-100 protein-positive cells in human colorectal cancer is unclear and was thus examined.	2003	14666729
tnm classification for lung cancer.	the international tumor-node-metastasis (tnm) staging system is the "international language" in cancer diagnosis and treatment. six revisions of the tnm staging system for lung cancer have been repeated over the past 35 years after the beginning of uicc-tnm classification in 1968. the 1997 revision for lung cancer has undergone an extensive correction for many deficiencies of the old staging system. as a result, the new staging system appears to be a great improvement over previous editions. the ...	2003	15003094
iodine supplementation restores fertility of sheep exposed to iodine deficiency.	the aims of the study were to monitor sheep iodine intake in different sheep breeding farms in abruzzo and to evaluate the effects of iodine supplementation on ovine fertility. the urinary iodine concentrations (uic) in animals of 8 out of the 11 breeding farms analyzed were borderline (uic 100-150 microg/l) or very low (uic < or = 50 microg/l). only animals bred in 3 farms showed an adequate iodine intake with a mean uic > or = 300 microg/l. animals with very low iodine intake had lower t4 and ...	2003	15008245
hypothyroidism associated with anti-human chorionic gonadotropin antibodies secondarily produced by gonadotropin therapy in a case of idiopathic hypothalamic hypogonadism.	we report a 22-yr-old male patient with idiopathic hypothalamic hypogonadism who showed secondary resistance to gonadotropin (gn) therapy over 3 yr after successful treatment with hcg combined with human menopausal gn. the patient simultaneously developed subclinical hypothyroidism. endocrine examination revealed low levels of testosterone (0.3 ng/ml), free t4 (0.91 ng/dl), and increased levels of tsh (31.1 microu/ml) in the serum. serum autoantibodies to thyroid gland were all negative. interes ...	2003	15008254
[psychiatric manifestations of vitamin b12 deficiency: a case report].	psychiatric manifestations are frequently associated with pernicious anemia including depression, mania, psychosis, dementia. we report a case of a patient with vitamin b12 deficiency, who has presented severe depression with delusion and capgras' syndrome, delusion with lability of mood and hypomania successively, during a period of two months. case report - mme v., a 64-year-old woman, was admitted to the hospital because of confusion. she had no history of psychiatric problems. she had histor ...	2003	15029091
chronic glue sniffing with transient central hypothyroidism and hypergonadotropism.	neuropsychiatric, gastrointestinal and muscular disorders associated with glue sniffing have been widely reported, but endocrinologic abnormalities of glue exposure are rarely mentioned in the literature. we report a 26-year old male patient, a chronic glue sniffer, who presented with weakness of both lower limbs. on physical examination, he had reduced muscle strength of his 4 limbs, especially in his lower limbs. laboratory examination revealed hypokalemia with hyperchloremic metabolic acidosi ...	2003	15015825
isoflavone supplements do not affect thyroid function in iodine-replete postmenopausal women.	despite the safety review conducted by the u.s. food and drug administration in the process of awarding a health claim for the cholesterol-lowering properties of soy protein, concerns about the possible goitrogenic effects of soybean isoflavones persist. concerns are based primarily on in vitro research, animal studies, and older reports of goiter in infants fed soy formula not fortified with iodine. in a randomized, double blind, placebo-controlled study, we investigated the effect on thyroid f ...	2003	14977438
symptomatic relief of patients with advanced bladder carcinoma after regional intra-arterial chemotherapy.	thirty-two patients (30 men, 2 women), median age 68 years (range 47-85) with histologically confirmed advanced bladder carcinoma (stages t3 and t4 according to the international union against cancer staging system), who were poor surgical candidates, were prospectively treated with 1-6 (median 4) cycles of intra-arterial epirubicin (60 mg/cycle) delivered through two infusion pumps that were surgically implanted to each internal iliac artery, along with intravenous leucovorin 200 mg per day and ...	2003	14981980
the effects of alpha interferon on the development of autoimmune thyroiditis in the nod h2h4 mouse.	alpha interferon (alphaifn) therapy is known to induce thyroid autoimmunity in up to 40% of patients. the mechanism is unknown, but th1 switching has been hypothesized. the aim of our study was to examine whether alphaifn accelerated the development of thyroiditis in genetically susceptible mice. we took advantage of nod-h2h4, a genetically susceptible animal model, which develops thyroiditis when fed a high iodine diet. six to eight week old male nod h2h4 mice were injected with mouse alphaifn ...	2003	14768947
[the cotransduction of pet system plasmids by mutants of t4 and rb43 bacteriophages].	the study of the cotransduction of the plasmid pairs pet-3a-plyse and pet-3a-plyss by the mutant phage t4alc7 showed that the antibiotic resistance markers of the plasmids were cotransduced with a high frequency. the analysis of the plasmid dna of cotransductants and cotransformants showed that the mutant phage t4alc7 can be used for obtaining the monomeric and oligomeric forms of plasmids and for the cotransduction of two-plasmid overproduction systems into e. coli strains. the plaque mutants r ...	2003	14768546
clinical application of proton beams in the treatment of uveal melanoma: the first therapies carried out in italy and preliminary results (catana project).	the first italian proton therapy facility was realized in catania, at the infn-lns. with its energy (62 mev proton beam), it is ideal for the treatment of shallow tumors like those of the ocular region: uveal melanoma, first of all (the most common primary intraocular malignancy of adults) and other less frequent lesions like choroidal hemangioma, conjunctiva melanoma, and eyelid tumors.	2003	14870772
effect of polychlorinated biphenyl, aroclor 1254 on rat epididymis.	polychlorinated biphenyls (pcb), the synthetic chlorinated organic compounds, are known to decrease thyroid function, sperm count and fertility, and increase the risk of testicular cancer may cause serious effect on male reproduction. the objective of the present study was to study the effect of pcb, aroclor 1254 on rat epididymal structure and function.	2003	14870796
thyroid indices and response to fluoxetine and nortriptyline in major depression.	we investigated: (i) the status of thyroid hormones and their clinical correlates in patients with major depression; (ii) changes in thyroid hormone status after treatment with fluoxetine versus nortriptyline; and (iii) whether blunted thyrotropin-stimulating hormone (tsh) response to thyrotropin-releasing hormone (trh) challenge predicts improvement after 6 weeks of fluoxetine versus nortriptyline treatment. patients with major depression entering a treatment trial were assessed with the struct ...	2003	14870956
effects of a mixture of polychlorinated biphenyls (aroclor 1254) on the transcriptional activity of thyroid hormone receptor.	polychlorinated biphenyls (pcbs) are environmental contaminants which may affect thyroid function. pcbs may reduce serum thyroid hormone (th) concentrations by either displacing t4 from th transport proteins or increasing its hepatic metabolism. the reduced serum t4 causes neurological and growth defects in animals exposed to pcbs during the perinatal period, which can partially be reverted by t4 administration. in addition to a hypothyroid-like syndrome, a direct action of pcbs on th-sensitive ...	2003	14759069
t4 but not t3 administration is associated with increased recurrence of graves' disease after successful medical therapy.	tsh has been incriminated in graves' disease for increasing the production of antibodies against tsh receptor (trab). it has been, therefore, suggested that t4 administration after successful antithyroid drug (atd) treatment may indirectly decrease the production of trab and, therefore, the frequency of recurrence of hyperthyroidism. to study the role of t4 and t3 on the recurrence rate of graves' disease 108 patients with graves' disease (22 males, age: 49.8 +/- 14.3 yr, mean +/- sd, and 86 fem ...	2003	14759070
three-week thyroxine withdrawal thyroglobulin stimulation screening test to detect low-risk residual/recurrent well-differentiated thyroid carcinoma.	measurement of serum tsh-stimulated thyroglobulin (tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (wdtc) in patients previously treated by surgery and radioactive iodine (rai) ablation therapy. wdtc patients who have an undetectable serum tg on thyroid hormone therapy (tht) in the absence of tg-antibody interference are considered to be at low risk for residual/recurrent disease. traditional management has been to withdraw t4 for 4- ...	2003	14759077
influence of bone invasion and extent of mandibular resection on local control of cancers of the oral cavity and oropharynx.	the aim of this paper was to evaluate the influence of bone invasion on treatment outcome among patients with cancers of the oral cavity and oropharynx and to determine whether or not outcome was influenced by the extent of mandibular resection. a review of 127 prospectively documented patients who were treated with marginal or segmental resection for oral (n = 110) and oropharyngeal (n = 17) cancers was undertaken. there were 97 males and 30 females with a median age of 61 years. clinical t sta ...	2003	14759107
[manifestations of selective visual attention in human parietal and temporal cortex according to evoked potentials].	the event-related potentials (erps) in visual discrimination task in parietal and temporal cortical areas were recorded in 11 young adults during passive observation (involuntary attention) and target selection (voluntary attention). the voluntary selective attention resulted in: 1) increased erp correlation between the parietal; and temporal cortical areas; 2) increased correlation of sequential erps in monopolar leads (p3, p4, t3, t4, t5, t6); and 3) increased correlation of sequential erps in ...	2003	14758613
[effect of lead acetate on the nerve growth factor protein expression and the regulation of thyroid hormone].	to study the effect of lead acetate on the expression of nerve growth factor (ngf) protein in rat brain and the regulation of thyroid hormone.	2003	14761347
[the expression and clinical implication of inducible nitric oxide synthase mrna in laryngeal carcinoma and hypopharyngeal carcinoma].	to study the expression of inducible nitric oxide synthase(inos) mrna in laryngeal carcinoma and hypopharyngeal carcinoma and its clinical significance.	2003	14727435
intraoperative effects of combined versus general anesthesia during major liver surgery.	the study compares the intraoperative effects of combined versus general anesthesia during major liver surgery.	2003	14743120
[application of bi-pedicel and bi-muscle flaps for the expanded partial laryngectomy in the patients with t3t4 laryngeal cancer].	to evaluate the application of bi-pedicel and bi-muscle flaps for the expanded partial laryngectomy in the patients with t3t4 larynx cancer.	2003	14743641
[preliminary study on the correlation factors of cervical lymphatic metastasis of glottic carcinoma].	to investigate the incidence of occult nodal in glottic carcinoma and access the correlation between the cervical lymph nodes metastases and originals of tumor.	2003	14743645
effects of maternal exposure to diethylstilbestrol on the development of the reproductive system and thyroid function in male and female rat offspring.	diethylstilbestrol (des) was administered subcutaneously at 1.5 or 15 microg/kg/day (des 1.5 group, des 15 group) to pregnant sd rats daily on days 7-21 of gestation to investigate its effects on the development and functions of the reproductive system and thyroid gland in their offspring. of the 11 pregnant rats in the des 15 group, only one delivered a live pup. rat pups in the des 1.5 group were autopsied at 1, 3, or 6 weeks after birth. in the des 1.5 group, the plasma t4 concentrations at a ...	2003	14746342
pcbs, hexachlorobenzene and dde are not associated with recurrent miscarriage.	a case-control study was designed to evaluate any associations between high exposure to polychlorinated biphenyls (pcb), hexachlorobenzene (hcb) and the 1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane (ddt) metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (dde) and recurrent miscarriage and immunoendocrine abnormalities.	2003	14750556
[treatment of the no neck in supraglottic cancer].	occult regional metastases in supraglottic cancer no are the object of classical controversies. the aim of our study is to provide our experience in order to determine how neck treatment affects on regional recurrence of no supraglottic cancer.	2003	14755919
mr staging of primary colorectal carcinoma: comparison with surgical and histopathologic findings.	we retrospectively evaluated the accuracy of magnetic resonance (mr) imaging in staging colorectal cancer and assessing local tumor extent, nodal involvement, and distant abdominal and pelvic metastases.	2003	14753591
flavonoids and thyroid disease.	the most potent natural plant-derived compounds that can affect thyroid function, thyroid hormone secretion and availability to tissues is the group of flavonoids, i.e. plant pigments. they are present in our daily food, such as vegetables, fruits, grains, nuts, wine, and tea. epidemiological studies suggest beneficial effects on health of flavonoids, which are commonly attributed to their activity as antioxidants. experimental studies in vitro, however, showed inhibition of organification in th ...	2003	14757961
[lipid abnormalities in elderly patients with subclinical hyperthyroidism].	sensitive thyroid-stimulating hormone (tsh) assays provide identification of many patients with subclinical hyperthyroidism resulting from excessive production or excessive replacement of thyroid hormone. subclinical hyperthyroidism is defined by a tsh below normal (suppressed) with normal serum t3 and t4 levels. subclinical hyperthyroidism is the goal of thyroid hormone therapy in patients with thyroid cancer, solitary thyroid nodules, multinodular or diffuse goiters, or a history of head and n ...	2003	15080051
osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism.	hyperthyroidism is characterized by increased bone turnover and resorptive activity. raised levels of serum osteoporotic cytokines, such as interleukin (il) -1beta, il-6 and tumor necrosis factor (tnf)-alpha have been demonstrated previously in hyperthyroidism. these elevations are controversial and it is difficult to differentiate the contribution of thyroid hormones to the elevation of cytokines from that of the autoimmune inflammation in graves' disease (gd) and follicular cell damage in thyr ...	2003	15074839
[functional properties of sphagnum magellanicum fiber and its direct use in formulation of bakery products].	characterization of functional properties of sphagnum magellanicum fiber were investigated. water absortion (wac) and water retention (wrc) capacities, swelling capacity (sc); organic molecule absortion capacity (omac) and cationic interchange capacity (cic) were evaluated, as well as its incorporation as fiber source to bakery produts. diferent particles sizes were selected to evaluate their effects on the functional properties of moss fiber: t1(1.4 mm);t2(1.0 mm); t3(0.42 mm); t4(0.18 mm). bes ...	2003	15125083
[adenoid cystic carcinoma of the head and neck: a review of 30 cases].	to evaluate treatment results and identify prognostics factors which determine local and regional treatment failure and crude survival in adenoid cystic tumours (act) in the head and neck.	2003	15038566
[effects of 7-oxo-dhea treatment on the immunoreactivity of balb/c mice subjected to chronic mild stress].	to determine whether 7-oxo-dehydroepiandrosterone (7-oxo-dhea) can reverse the hypoimmunity in balb/c mice exposed to chronic mild stress.	2003	15040075
[tracheoesophageal shunt for voice reconstruction after total laryngectomy to prevent from deglutition disorders].	to observe the effect of tracheoesophageal shunt on voice reconstruction after total laryngectomy.	2003	15040105
oromandibular reconstruction with simultaneous free flaps: experience on 10 cases.	composite defects resulting from surgery for advanced oral cancer represent a difficult reconstructive problem and, in some cases, tissutal defects are extensive requiring multiple free flaps. personal experience is reported with double free-flap technique in the reconstruction of large complex defects in 10 patients treated for t4 oral squamous-cell carcinoma. fibula osteo-cutaneous free flap was used in association with forearm free flap in 5 cases, fibula osseous-forearm in 3 cases, fibula os ...	2003	15046417
circulating nitric oxide is modulated by recombinant human tsh administration during monitoring of thyroid cancer remnant.	during the administration of recombinant human tsh (rhtsh) to monitor differentiated thyroid carcinoma, mild side effects, such as nausea and headaches, often occur. the origin of these is not clear. since changes in tsh and thyroid hormones can modulate some endothelial-derived factors, we aimed at testing whether rhtsh administration induces changes in nitric oxide. we studied 25 patients (56.6+/-12.6 yr) who had undergone thyroidectomy followed by ablative radioiodine for papillary thyroid ca ...	2003	15055471
[xeroderma pigmentosum: children of the moon].	xeroderma pigmentosum is based on a genetic defect in the dna repair system, which is diagnosed in early childhood. xeroderma pigmentosum is a rare disorder, which is transmitted in an autosomal recessive manner. children with xeroderma pigmentosum display hypersensitivity to ultraviolet (uv) radiation. these patients experience serious sunburns with minimal exposure and then develop poikiloderma in the sun-exposed areas. squamous cell carcinomas, basal cell carcinomas and malignant melanomas al ...	2003	16285494
bexarotene--an alternative therapy for progressive cutaneous t-cell lymphoma? first experiences.	a standard therapy for advanced cutaneous t-cell lymphomas has not yet been defined. bexarotene is a new retinoid x receptor-specific retinoid that has been approved for systemic second-line therapy for cutaneous t-cell lymphomas in the usa and europe. in order to evaluate the efficacy of bexarotene in cutaneous t-cell lymphomas, a pilot trial was initiated.	2003	16281814
newborn screening in indonesia.	in indonesia, newborn screening is not yet a policy, and the incidence of preventable causes of mental retardation detected by newborn screening is not known. congenital hypothyroidism (ch) is not infrequent. without a screening program, unrecognized ch patients were neglected for years. since may 1999, the international atomic energy agency (iaea) has assisted in starting a ch newborn screening project to estimate the local incidence of ch and to evaluate the problems associated with the screen ...	2003	15906701
national neonatal hypothyroid screening program in mongolia.	this study was motivated by the desire to identify patients with congenital hypothyroidism for early treatment. a pilot project was developed by the department of nuclear medicine and initial screening was began at 2 of the maternity houses in ulaanbaatar. the methodology used for these activities involved collecting samples by heel prick at 3-4 days of age and analysed for tsh by immunoradiometric testing (skybio ltd, united kingdom). from july 2000 to september 2001, 1,529 babies were screened ...	2003	15906704
the utility of ft4 serum in newborns at risk for congenital hypothyroidism (ch).	thyrotropin (tsh) stimulates hormonogenesis using the iodate substrate and tyrosine amino acid. after various enzymatic reactions, thyroxine (t4) and triiodothyronine (t3) are released. part of the hormone freely circulates in serum as free t3 (ft3) and free t4 (ft4). tsh is released after feedback. a study was undertaken to determine cut-off levels of ft4 to verify hypothalamic and pitutitary hypothyroidism. both tsh and t4 were determined on blood spots by chemoluminescence and radioimmunology ...	2003	15906723
screening for congenital hypothyroidism--a new era in bangladesh.	neonatal screening is a new concept in bangladesh. currently a pilot program is ongoing where newborns are screened for congenital hypothyroidism (ch). in a country like bangladesh, where people are still fighting childhood problems like malnutrition, diarrhea and other communicable diseases with a high infant and child mortality rate, instituting a newborn screening program is a challenge. tsh is measured on filter paper using irma methods. both cord and heel prick blood are used. a cut off val ...	2003	15906726
thyroid function in patients with amyotrophic lateral sclerosis.	amyotrophic lateral sclerosis (als) is a neurodegenerative disease affecting motor neurons. etiopathogenesis of the disease is not known. it is supposed that immunological disturbances play a role, which is among others confirmed by coexistence of als with autoimmunological disorders, including thyroid diseases. the aim of the study was to investigate the thyroid function in als through the measurement of triiodothyronine (t3), thyroxine (t4), and thyroid stimulating hormone (tsh) in the serum o ...	2003	15315012
effect of dosing and sampling time on serum thyroxine, free thyroxine, and thyrotropin concentrations in dogs following multidose etodolac administration.	thirty-eight dogs with orthopedic disorders received etodolac, an nsaid, at 10.0 to 13.3 mg/kg po once daily for 14 to 19 days. mean total thyroxine (t4), free thyroxine (ft4), and canine thyrotropin (ctsh) values before and after etodolac administration were compared using paired t-tests. a significant (p <.05) decrease in t4 values occurred after etodolac administration with 21% of these values falling below the reference range. a significant (p <.05) increase in ctsh following etodolac admini ...	2003	15136976
a comparative study on diagnostic differentials of t3 and t4 hormones for thyroid disorders.	results of thyroid function tests of 671 individuals have been studied. the analysis shows that t3 and t4 hormone tests are not efficacious as compared to tsh test (p < 0.001) and in diagnosing hypothyroid cases t3 and t4 lead to almost same results while in detecting hyperthyroid cases t3 is superior to t4 (p < 0.01).	2003	15129853
mixed mold mycotoxicosis: immunological changes in humans following exposure in water-damaged buildings.	the study described was part of a larger multicenter investigation of patients with multiple health complaints attributable to confirmed exposure to mixed-molds infestation in water-damaged buildings. the authors present data on symptoms; clinical chemistries; abnormalities in pulmonary function; alterations in t, b, and natural killer (nk) cells; the presence of autoantibodies (i.e., antinuclear autoantibodies [ana], autoantibodies against smooth muscle [asm], and autoantibodies against central ...	2003	15143854
evaluation of downstaging as leading concept in sphincter-saving surgery for rectal cancer after preoperative radio-chemotherapy (preop rct).	to evaluate the downstaging of rectal cancer after preop r +/- ct.	2003	15139712
metabolic effects of dietary lactose in adult female rats.	as an outgrowth of our interest in the potential toxicity of dietary galactose, we investigated the metabolic effects of high lactose diets in long-evans female rats. seventy-five long-evans female rats (25-day-old) were randomized to receive one of 3 diets for 7 months: glucose diet (con); low lactose diet (10.5%, lld); or a high lactose diet (41.9%, hld). necropsy was performed seven months after randomization. hld animals had significantly lower body weights than controls (p < 0.01). these an ...	2003	15141440
relation between helicobacter pylori infection, thyroid hormone levels and cardiovascular risk factors on blood donors.	the aim of this study was to assess the relationship between helicobacter pylori (hp) infection, serum thyroid hormone levels and certain cardiovascular risk factors in normal volunteers. in 110 blood donors (85 men, 25 women, aged 35.6 +/- 9.76) the serum levels of igg antibodies against hp were estimated using a sensitive immunoassay. serum estimation of t3, t4, tsh, ft3, ft4, thyroid (microsomial) autoantibodies, c-reactive-protein, a1-acid-glycoprotein, vitamin b12, folic acid, cholesterol, ...	2003	15244214
correlation of autonomic indices with thyroid status.	the autonomic status in female thyroid patients was compared with healthy, age matched normal females taken as controls. the patients (29 +/- 7 years) were categorised into two groups: hyperthyroid and hypothyroid. the valsalva manoeuvre, standing to lying ratio (s/l ratio) and immediate heart rate response to standing (30:15 ratio) to assess the parasympathetic status while the galvanic skin response (gsr) was recorded to assess the sympathetic status. statistical analysis was done using studen ...	2003	15255619
the management of glottic and supraglottic cancers of the larynx in relation to neck metastasis.	we evaluated the management of glottic and supraglottic laryngeal cancers in relation to neck metastasis.	2003	15542939
can selective retroperitoneal lymphadenectomy be better than unilateral retroperitoneal lymphadenectomy?	to propose a new modality of retroperitoneal lymphadenectomy as a complementary treatment for patients with high risk, stage i nonseminomatous testicular tumor.	2003	15745585
united arab emirates national newborn screening programme: an evaluation 1998-2000.	to evaluate the united arab emirate national newborn screening programme we compared coverage, timeliness of programme indicators (age at sampling, recall and treatment initiation, timing of specimen delivery and laboratory results) and specimen quality with international standards. recall rate, sensitivity, specificity, positive predictive values and relative incidence rates for phenylketonuria (pku) and congenital hypothyroidism (ch) were calculated. investigations for hypothyroidism included ...	2003	15751925
low dose interleukin-2 and 13-cis-retinoic acid as maintenance therapy in patients with solid tumors responsive to chemotherapy.	after aggressive surgery and chemotherapy, patients (pts) with advanced solid tumors have often an impaired immune function that may facilitate tumor relapse. we have demonstrated, in a phase ib study, that administering low-dose interleukin-2 (il-2) and 13-cis retinoic acid (ra), there was a significant improvement of the immune function, with low toxicity, in pts with advanced tumors that had been treated with aggressive surgery and chemotherapy (clin cancer res 7: 1251-1257, 2001). a further ...	2003	16767920