Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [changes of endocrine hormones during -6 degrees head down bed rest in human]. | objective: to investigate changes of endocrine hormones during 7 d head down bed rest (hdbr). method: six healthy male volunteers served as the subjects and experienced 7 d -6 degrees hdbr. urine was collected from 6:00-22:00 and from 22:00-6:00. serum was collected 48 h before hdbr, 48 h and 120 h during hdbr. then the endocrine indices in urine and serum were determined. result: 1) the levels of serum cort and ald increased at 48 h during hdbr, while serum t3, t4, tp, un decreased but they all ... | 2003 | 14594038 |
| thyroid function tests in preterm infants born to preeclamptic mothers with placental insufficiency. | since preeclampsia causes placental insufficiency, it can be hypothesized that it decreases placental passage of thyroxine (t4) from mother to infant and thus may deepen the transient hypothyroxinemia seen in preterm infants after birth. the aim of this study was to compare thyroid function tests of preterm infants born to preeclamptic mothers with placental insufficiency with preterm infants born to mothers without placental insufficiency. | 2003 | 14594173 |
| diagnostic delay and prognosis in invasive bladder cancer. | to study diagnostic delay in invasive bladder cancer in a population-based material with long-term follow-up, and to evaluate whether delay in diagnosis affects the risk of bladder cancer death. | 2003 | 14594688 |
| [toxic multinodular goiter]. | we report a series of 70 patients with toxic multinodular goiter (tmng) and analyze results after surgical removal. | 2003 | 14595241 |
| hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. case report. | the frequency of myopathy in hypothyroidism ranges from 30 to 80%. the major symptoms related are weakness, muscular cramps and myalgia. the pseudohyperthrophic form is called hoffman's syndrome. the electrophysiological study reveals myopathy, neuropathy or mixed pattern. laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (tsh) elevated. the treatment consists in hormone replacement and the prognosi ... | 2003 | 14595495 |
| prevalence of thyroid dysfunction in patients with acute atrial fibrillation attended at a cardiology emergency room. | atrial fibrillation occurs frequently in patients with thyrotoxicosis, while it has low prevalence in adults of the general population. the prevalence of thyroid dysfunction in subjects with atrial fibrillation is 0 to 24%, a wide variation that is attributed to the different methodologies applied. however, continuous use of amiodarone in patients with previous atrial fibrillation may interfere with these prevalence rates. | 2003 | 14595508 |
| nmr structure and dynamics of the second transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit. | structure and backbone dynamics of a selectively [(15)n]leu-labeled 28-residue segment of the extended second transmembrane domain (tm2e) of the human neuronal nicotinic acetylcholine receptor (nachr) beta(2) subunit were studied by (1)h and (15)n solution-state nmr in dodecylphosphocholine micelles. the tm2e structure was determined on the basis of the nuclear overhauser effects (noes) and the hydrogen bond restraints, which were inferred from the presence of h(alpha)(i)-h(n)(i+3), h(alpha)(i)- ... | 2003 | 14596621 |
| segg endonuclease promotes marker exclusion and mediates co-conversion from a distant cleavage site. | bacteriophages t2 and t4 are closely related t-even phages. however, t4 genetic markers predominate in the progeny of mixed infections, a phenomenon termed marker exclusion. one region previously mapped where the frequency of t2 markers in the progeny is extremely low is located around gene 32. here, we describe segg, a giy-yig family endonuclease adjacent to gene 32 of phage t4 that is absent from phage t2. in co-infections with t2 and t4, cleavage in t2 gene 32 by t4-encoded segg initiates a g ... | 2003 | 14596796 |
| defining the bacteriophage t4 dna packaging machine: evidence for a c-terminal dna cleavage domain in the large terminase/packaging protein gp17. | double-stranded dna packaging in bacteriophage t4 and other viruses occurs by translocation of dna into an empty prohead by a packaging machine assembled at the portal vertex. coordinated with this complex process is the cutting of concatemeric dna to initiate and terminate dna packaging and encapsidate one genome-length viral dna. the catalytic site responsible for cutting, and the mechanisms by which cutting is precisely coordinated with dna translocation remained as interesting open questions ... | 2003 | 14596798 |
| lip cancer treatment with high dose rate brachytherapy. | we present 39 patients with lip carcinoma treated with hdr, (needles) with 5-5.5 gy per 8-10 fractions b.i.d. (total dose 40.5-45 gy). three-year cause-specific survival and local control are 91 and 88% (95% t1-2, 74% t4, p<0.05). acute and chronic reactions are like ldr cases. we think that hdr results are equivalent to ldr. | 2003 | 14597364 |
| intrahepatic cholangiocarcinoma: macroscopic type and stage classification. | the liver cancer study group of japan established a classification of macroscopic type and the tnm staging of intrahepatic cholangiocarcinoma (icc). with the observation of more than 240 resected cases of icc, three fundamental types were established. they were: (1) mass-forming (mf) type, (2) periductal-infiltrating (pi) type, and (3) intraductal growth (ig) type. the mf type forms a definite mass, located in the liver parenchyma. the pi type is defined as icc which extends mainly longitudinall ... | 2003 | 14598147 |
| persistence of mild hyperthyrotropinemia after discontinuation of three-year course of low-dose l-thyroxine therapy in infants with borderline hypothyroidism. | treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. in this study, changes in thyroid function after discontinuation of low-dose l-thyroxine (l-t4) supplement in infants with the condition were evaluated. fourteen infants with hyperthyrotropinemia at neonatal screening had repeated hyperthyrotropinemia (> 8 mu/l) with normothyroxinemia. tsh response was exaggerated at trh testing. the subjects were treated ... | 2003 | 14599110 |
| in vitro studies on dna-photosensitization by different drug stereoisomers. | the possible stereoselectivity in dna-photosensitization by carprofen (a nsaid drug) and ofloxacin (a fluoroquinolone agent) was investigated. the different drug stereoisomers or racemic mixtures were uva-irradiated and the relaxation of the supercoiled circular pbr322 quantified by electrophoresis. formation of single strand breaks was compared for each group of compounds. moreover a mechanistic study by means of repair enzymes: t4 endonuclease v (specific of cyclobutane pyrimidine dimers), e. ... | 2003 | 14599458 |
| hyperthyroidism modifies ecto-nucleotidase activities in synaptosomes from hippocampus and cerebral cortex of rats in different phases of development. | here we investigate the possible effects of the hyperthyroidism on the hydrolysis of the atp to adenosine in the synaptosomes of hippocampus, cerebral cortex and blood serum of rats in different developmental phases. manifestations of hyperthyroidism include anxiety, nervousness, tachycardia, physical hyperactivity and weight loss amongst others. the thyroid hormones modulate a number of physiological functions in central nervous system, including development, function, expression of adenosine a ... | 2003 | 14599486 |
| definitive radiotherapy alone or combined with a planned neck dissection for squamous cell carcinoma of the pharyngeal wall. | in the current study,the authors analyzed the results of definitive radiotherapy for squamous cell carcinoma of the pharyngeal wall. | 2003 | 14601093 |
| temporal and topographic ultrastructural alterations of rat heart myofibrils caused by thyroid hormone. | in order to further our understanding regarding the temporal and topographic ultrastructural aspects of the myocardium under thyrotoxicosis, thyroxine (t4; 25 and 100 microg/100 g bw) was administered to young rats 24 hours after birth until 15 days. the animals were then sacrificed, the hearts excised and weighed, and the ventricle tissue samples were then processed for confocal and transmission electron microscopy. at 48/72 hours and 1 week after initiation of t4 treatment with 100 microg/100 ... | 2003 | 14601151 |
| [influence of inhaled nitric oxide on surfactant in the total cardiopulmonary bypass pig model]. | to study whether or not inhaled nitric oxide (ino) can improve surfactant production and pulmonary mechanics after cpb in pigs, and to seek the mechanism of lung injury during mechanical ventilation. | 2003 | 14601318 |
| soluble hla-g molecules are increased in lymphoproliferative disorders. | the immunomodulatory properties of soluble human leukocyte antigen g (shla-g) explain its potential interest in malignancies. hla-g frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. in this article, we will demonstrate that the plasmatic level of soluble hla-g was significantly increased in 70% of b chronic lymphocytic leukemia, 53% of non-hodgkin b lymphoma (b-nhl), and 45% of t-nhl. to explain this variable secretion, the hla-g secreting cell was sear ... | 2003 | 14602240 |
| radical radiation vs surgery plus post-operative radiation in advanced (resectable) supraglottic larynx and pyriform sinus cancers: a prospective randomized study. | survival in head and neck cancers reflect loco-regional control. with an aim of organ and function preservation the present study was undertaken to compare local failure and survivals. | 2003 | 14602495 |
| comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid. | euthyroid goiter is usually treated with tsh-inhibitory doses of levo-t(4) (l-t(4)). because triiodothyroacetic acid (triac) decreases tsh levels, the following study was perfomed: 36 euthyroid goitrous female patients (no cancer or chronic thyroiditis) were randomized to triac (19.6 micro g/kg) (n = 19) or l-t4 (1.7 microg/kg) (n = 17) treatment during 11 months. goiter volume; lumbar and femoral bone mineral density; serum osteocalcin; deoxypyridinoline; tsh; free t(4); total, high-density lip ... | 2003 | 14602763 |
| the syndrome of resistance to thyroid stimulating hormone. | resistance to thyroid stimulating hormone (tsh) is a syndrome of reduced sensitivity to a biologically active tsh molecule. subjects have elevated tsh levels but no goiter. however, thyroid hormone concentration may vary from normal to very high, depending on the severity of the resistance. individuals with very high tsh, low thyroxine (t4) and hypoplastic thyroid glands can be mistakenly diagnosed as having primary hypothyroidism due a defective development of the thyroid gland. those with norm ... | 2003 | 14604307 |
| perioperative chemotherapy in advanced bladder cancer - part ii: adjuvant treatment. | despite radical cystectomy, 40% of the patients with locally advanced disease and more than 80% of the patients with lymphatic metastases die tumor related. this provides the rationale for additional effective systemic therapy following surgery. in addition, previous surgery and consecutive histopathological or cell-based evaluation offers the advantage to expose only those patients to adjuvant systemic chemotherapy, who belong to a defined high-risk group. regional lymph node metastases range f ... | 2003 | 14605467 |
| recombinant human tsh changes the multidisciplinary approach to patients with differentiated thyroid carcinoma. two-year experience. | recombinant human tsh (rhtsh) is available for monitoring differentiated thyroid carcinoma. rhtsh testing modifies the guidelines for this disease. | 2003 | 14605601 |
| the thyroid during pregnancy: a physiological and pathological stress test. | pregnancy and the postpartum are times of marked and rapid change in the thyroid gland. normal physiological changes include enhanced thyroid hormone production, modulation of thyroid hormone metabolism by placental deiodinases, and decreasing titers of thyroid antibodies in thyroid antibody positive women. hyperemesis gravidarum is associated with suppressed thyroid stimulating hormone levels and free t4 elevations. graves' disease typically becomes quiescent during pregnancy, followed by a pos ... | 2003 | 14605605 |
| [indications for neoadjuvant therapy in rectal carcinoma]. | pre- and postoperative adjuvant treatments for locally advanced, operable (r0 resection) rectum carcinoma have led to improved results. in principle, according to the interdisciplinary consensus of the german cancer society, the recommended treatment for rectum carcinoma (t3/4; n0; m0; any t stage; n+; m0) is still postoperative adjuvant radiochemotherapy. in the meantime, however, based on the good results obtained from various clinical trials preoperative adjuvant treatment is favored internat ... | 2003 | 14605730 |
| evening and morning eeg differences between young men and women adults. | evening and morning waking eeg (eyes closed) was recorded in 16 women and 13 men aged 18-26 years old. participants were fitted with a 13-electrode montage (fp1, fp2, fz, f7, f8, c3, c4, t3, t4, p3, p4, o1, and o2) referred to linked ears. for each recording electrode, eeg total spectral amplitude power (microv/hz, 0.75-19.75 hz) was compared using 2 (gender) x 2 (moments) analyses of variance for repeated measures and lsd post-hoc tests. we found significant simple gender effects, with women di ... | 2003 | 14607135 |
| the role of dna recombination in herpes simplex virus dna replication. | in many organisms the processes of dna replication and recombination are closely linked. for instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. replication restart is an essential mechanism in which the recombination and repair machinery can be used to continue replication after such a catastrophic event. dna viruses of bacteria such as lambda and t4 also rely heavily on dna recombinati ... | 2003 | 14609200 |
| fruit extract of emblica officinalis ameliorates hyperthyroidism and hepatic lipid peroxidation in mice. | the ethanolic extract from the fruits of emblica officinalis gaertn (euphorbiaceae) was investigated to evaluate its possible ameliorating effects, on the l-thyroxine (l-t4) induced hyperthyroidism and on hepatic lipid peroxidation in mice. while an increase in serum t3 (triiodothyronine) and t4 (thyroxine) concentrations, and in a thyroid dependent parameter, hepatic glucose 6-phospatase (glu-6-pase) activity was observed in l-t4 (0.5 mg/kg/d) treated animals, simultaneous oral administration o ... | 2003 | 14609291 |
| brown-sèquard syndrome produced by cervical disc herniation: report of two cases and review of the literature. | brown-sèquard syndrome is most commonly seen with spinal trauma and extramedullary spinal neoplasm. a herniated cervical disc has rarely been considered to be a cause of brown-sèquard syndrome. | 2003 | 14609700 |
| [the influence of surgical intervention on the functional status of hypophyseal-thyroid system in patients with acute destructive appendicitis]. | the changes of thyrotropin (tsg), thyroxin (t4) and triiodothyronine (t3) blood levels in patients with acute destructive appendicitis and initial decrease of t3, as well as its absorption of t4 by lymphocytes after operation were studied. it is established that "low t3 level syndrome" in surgical patients exceeds the limit of quantitative assessment of the level of thyroid hormones' concentration in peripheral blood. it includes also damage of functional intersystem (endocrine-immune) links. ho ... | 2003 | 14610789 |
| light-induced hormone conversion of t4 to t3 regulates photoperiodic response of gonads in birds. | reproduction of many temperate zone birds is under photoperiodic control. the japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. studies on this animal have suggested that the mediobasal hypothalamus (mbh) is an important centre controlling photoperiodic time measurement. here we report that expression in the mbh of the gene encoding type 2 iodothyronine deiodinase (dio2), which c ... | 2003 | 14614506 |
| structure of dna hexamer sequence d-cgatcg by two-dimensional nuclear magnetic resonance spectroscopy and restrained molecular dynamics. | solution conformation of self-complementary dna duplex d-cgatcg, containing 5' d-cpg 3' site for intercalation of anticancer drug, daunomycin and adriamycin, has been investigated by nuclear magnetic resonance (nmr) spectroscopy. complete resonance assignments of all the protons (except some h5'/h5" protons) have been obtained following standard procedures based on double quantum filtered correlation spectroscopy (dqf cosy) and two-dimensional nuclear overhauser effect (noe) spectra. analysis of ... | 2003 | 14616036 |
| broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the royal marsden hospital. | to determine if it is possible to exclude staging bone scans in a greater proportion of patients if more consideration is given to t stage and gleason score, as recent guidelines from the national institute of clinical excellence state that routine staging bone scans for prostate cancer are unnecessary in patients with a prostate specific antigen level (psa) of < 10 ng/ml and gleason scores of < 8. | 2003 | 14616446 |
| decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function. | this case-control study was carried out to assess whether levothyroxine (l-t4) replacement might cause regression of the enhanced atherosclerosis seen in hypothyroid patients. | 2003 | 14616885 |
| serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. | adipose tissue is a hormonally active system that produces and releases different bioactive substances. leptin, adiponectin and resistin are some of the recently discovered adipocytokines that participate in the regulation of intermediate metabolism. the aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy. | 2003 | 14616887 |
| [an applied anatomy study on bronchial artery and posterior intercostal artery]. | to provide anatomic data for clinical treatment of the right lung cancers at advanced or intermediate advanced stage. | 2003 | 14619589 |
| life-threatening hyponatremia due to cessation of l-thyroxine. | electrolyte disorders in hypothyroidism are frequently subtle and rarely observed in clinical practice. a 50-year-old woman was admitted to the emergency room with complaints of nausea, weakness, and lethargy. her medical history revealed total thyroidectomy two years earlier. she was commenced on l-thyroxine after the surgery. however, the patient stopped the treatment for three months. thyroid function tests showed free t3 0.80 pg/ml (n: 1.8-4.2), free t4 <0.20 ng/dl (n: 0.8-1.9), tsh 56.84 mi ... | 2003 | 14620714 |
| sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster. | oligodendrocytes and myelin in the corpus callosum of black tremor and normal hamsters aged over 1.5 years were ultrastructurally examined to determine the myelination index (ratio of myelin thickness/diameter of axon), percentage of naked axons, and proportions of oligodendroglial subtypes (light, medium and dark). the mutant hamsters were remarkably hypomyelinated, with a low myelination index and a high proportion of naked axons, and high proportions of the dark subtypes. serum concentrations ... | 2003 | 14621228 |
| interaction of the c1 complex of complement with sulfated polysaccharide and dna probed by single molecule fluorescence microscopy. | the complex c1 triggers the activation of the complement classical pathway through the recognition and binding of antigen-antibody complex by its subunit c1q. the globular region of c1q is responsible for c1 binding to the immune complex. c1q can also bind nonimmune molecules such as dna and sulfated polysaccharides, leading either to the activation or inhibition of complement. the binding site of these nonimmune ligands is debated in the literature, and it has been proposed to be located either ... | 2003 | 14622259 |
| kinetics and thermodynamics of nick sealing by t4 dna ligase. | t4 dna ligase is an mg2+-dependent and atp-dependent enzyme that seals dna nicks in three steps: it covalently binds amp, transadenylates the nick phosphate, and catalyses formation of the phosphodiester bond releasing amp. in this kinetic study, we further detail the reaction mechanism, showing that the overall ligation reaction is a superimposition of two parallel processes: a 'processive' ligation, in which the enzyme transadenylates and seals the nick without dissociating from dsdna, and a ' ... | 2003 | 14622296 |
| regulation of translation of the head protein of t4 bacteriophage by specific binding of ef-tu to a leader sequence. | recent evidence indicates that translation elongation factor tu (ef-tu) has a role in the cell in addition to its well established role in translation. the translation factor binds to a specific region called the gol region close to the n terminus of the t4 bacteriophage major head protein as the head protein emerges from the ribosome. this binding was discovered because ef-tu bound to gol peptide is the specific substrate of the lit protease that cleaves the ef-tu between amino acid residues gl ... | 2003 | 14623179 |
| detection of endocrine-modulating effects of the antithyroid acting drug 6-propyl-2-thiouracil in rats, based on the "enhanced oecd test guideline 407". | the antithyroid acting drug propylthiouracil (ptu) was administered to male and female wistar rats at 0, 0.1, 1, or 10mg/kg body weight for 4 weeks according to the draft protocol of the "enhanced oecd test guideline 407" (enhanced tg 407) in order to investigate its suitability to detect endocrine-mediated effects. the study was conducted with two identical subsets of five animals per sex and dose each to provide data on sensitivity. the modified protocol includes the investigation of additiona ... | 2003 | 14623486 |
| letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy. | letrozole, a third generation aromatase inhibitor, has been compared with tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy. in a first-line trial in advanced disease, 939 post menopausal women were randomised double blind to receive treatment with letrozole 2.5 mg daily or tamoxifen 20 mg daily. letrozole was significantly superior in terms of median time to progression (9.4 months versus 6.1 months, p=0.0001), objective response (30% versus 20%, p=0.0006), and cli ... | 2003 | 14623523 |
| prognostic factors affecting the outcome of nasopharyngeal carcinoma. | the aim of the study is to evaluate patients with nasopharyngeal carcinoma treated with multisegmental intensity-modulated radiotherapy with or without chemotherapy and analyze patient, tumor and treatment characteristics, determining outcome. | 2003 | 14623917 |
| neo adjuvant tamoxifen in post menopausal patients with operable breast cancer. | tamoxifen is widely used as adjuvant therapy in receptor positive post menopausal breast cancer. little is known about its efficacy as neo adjuvant therapy in terms of breast conservation and improved survival. | 2003 | 14624772 |
| sage mrna expression in advanced-stage lung cancers. | sage and hage are recently isolated genes, which were thought to be expressed tumour-specifically, and are potentially coding for tumour-specific antigens recognized by t lymphocytes. the expression of these genes may serve as a useful diagnostic marker in detecting malignant disease. we report the correlation of sage and hage expression with clinicopathological features in patients with lung cancer who had undergone surgery. | 2003 | 14624785 |
| establishment of an hiv cell-cell fusion assay by using two genetically modified hela cell lines and reporter gene. | infection of human cells with the human immunodeficiency virus type i (hiv-1) can be mimicked by a fusion process between cells expressing the hiv envelope protein (env) and cells expressing both human cd4 together with the appropriate human chemokine receptors. in this study, a t-tropic hiv cell-cell fusion assay was established that utilized cd4, human cxcr4 and hiv nl4-3 gp160 as fusion components and a t7 polymerase-activated luciferase as a reporter system. the hela t4 cells used, expressed ... | 2003 | 14625051 |
| structure and morphogenesis of bacteriophage t4. | bacteriophage t4 is one of the most complex viruses. more than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic dna, a 'tail,' and fibers, attached to the distal end of the tail. the fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. the tail also serves as a channel for delivery of the phage dna from the head into the host cell cytoplasm. the ... | 2003 | 14625682 |
| the treatment of cutaneous t-cell lymphoma with photopheresis. | photopheresis or extracorporeal photochemotherapy (ecp) is an immunomodulating procedure that has been available for the treatment of cutaneous t-cell lymphoma (ctcl) since 1987. a concentrated white blood cell (wbc) sample spiked with 8-methoxypsoralen (methoxsalen) is exposed to an ultraviolet a light source, then all blood components are returned to the patient. treatment of mycosis fungoides (mf) and sézary syndrome (ss) with ecp has been reported in over 400 patients. the combined overall r ... | 2003 | 14686977 |
| gene therapy for human immunodeficiency virus infection in the humanized scid mouse model. | the humanized scid mouse model is an attractive tool for testing gene therapy to combat human immunodeficiency virus infection in vivo. | 2003 | 14689754 |
| evaluation of the impact of an iodine supplementation programme on severely iodine-deficient schoolchildren with hypothyroidism. | northern rural areas of tehran have been shown to have severe iodine deficiency in our previous studies. in 1989 the inhabitants of these villages received an injection of iodised oil, followed by iodised salt distribution in 1993. the aim of the present study was to evaluate the effect of the iodine supplementation on iodine-deficient schoolchildren with hypothyroidism in these villages. | 2003 | 14690034 |
| successful management of a pregnant woman with a tsh secreting pituitary adenoma with surgical and medical therapy. | we described a 39-yr-old asian female who was initially diagnosed with prolactinoma and presented with increase nervousness and weight loss. laboratory evaluation revealed an inappropriately normal tsh level with elevated free t4, total t3, alpha-subunit and prolactin level. the alpha-subunit/tsh molar ratio was 4. mri showed a macroadenoma extending to the suprasellar cistern. treatment was begun with propylthiouracil and bromocriptine. after 5 months of therapy, she became pregnant. at 27 week ... | 2003 | 14703021 |
| non-systematic screening for prostate cancer in sweden--survey from the national prostate cancer registry. | the large increase in the incidence of prostate cancer is largely due to testing of serum levels of prostate-specific antigen (psa). little is known about how psa testing is used in clinical practice outside of screening programmes. essentially, psa can be used in the health check-ups of men without symptoms as a form of non-systematic screening or in the work-up of symptomatic patients. the aim of this study was to investigate the cause of initiating a work-up leading to a diagnosis of prostate ... | 2003 | 14675917 |
| validation of a transfusion prediction model in head and neck cancer surgery. | allogeneic transfusions are necessary in 14% to 80% of patients undergoing major head and neck cancer surgery. defining the risk for receiving allogeneic transfusion allows for informed decisions regarding appropriateness of type and crossmatch, preoperative autologous blood donation, and priming with erythropoietin. based on logistic regression analysis of transfusion risk factors in 438 patients, we developed a transfusion prediction risk assessment (tpra) model to determine the need for trans ... | 2003 | 14676155 |
| fgfr3 and tp53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder. | fgfr3 and tp53 mutations are frequent in superficial papillary and invasive disease, respectively. we used denaturing high-performance liquid chromatography and sequencing to screen for fgfr3 and tp53 mutations in 81 newly diagnosed urothelial cell carcinomas. tumors were classified as follows: 31 pta, 1 carcinoma in situ, 30 pt1, and 19 pt2-t4. tumor grades were as follows: 10 g1, 29 g2, and 42 g3. fgfr3 mutations were associated with low-stage (p < 0.0001), low-grade (p < 0.008) tumors, wherea ... | 2003 | 14678961 |
| monthly changes in some reproductive parameters and in testosterone and thyroxine values of rams throughout one year under continental climate conditions. | ten sexually mature rams were used in this study. blood and semen was collected monthly from rams for one period of 12 months to study semen characteristics and to determine serum testosterone and thyroxine (t4) hormones. results showed that all of the rams are continuous breeders as they show sexual desire and produce semen throughout the whole year. however, monthly variations in reproductive and semen characteristics were detected. relative testes volume, ejaculate volume, sperm motility, spe ... | 2003 | 14679837 |
| plasma total homocysteine concentrations in adults with growth hormone (gh) deficiency: effects of gh replacement. | growth hormone (gh) deficiency is associated with increased cardiovascular morbidity and mortality. gh treatment improves the profile of many cardiovascular risk markers in individuals with gh deficiency (ghd). the aim of the present was to assess whether gh replacement may decrease plasma total homocysteine, an independent cardiovascular risk factor, thus potentially contributing to benefits of gh replacement in adult subjects with ghd. twenty-five patients (17 female, 8 male), mean age 39-year ... | 2003 | 14680980 |
| relationships existing between the serum cytokine levels and bone mineral density in women in the premenopausal period affected by graves' disease with subclinical hyperthyroidism. | we examined the relationships existing between serum cytokine levels and bone mineral density (bmd) in women of premenopausal age affected by graves' disease with subclinical hyperthyroidism. the study population consisted of 21 women with untreated hyperthyroid graves' disease (group h) (age, 36 +/- 2 years), eight women with untreated subclinical hyperthyroid status (group sh) (age, 33 +/- 5 years) and 10 healthy women (group n) (age, 35 +/- 3 years). the following measurements were made in al ... | 2003 | 14682468 |
| pinealectomy and zinc deficiency have opposite effects on thyroid hormones in rats. | the present study was conducted to investigate how pinealectomy and zinc deficiency separately or in combination affected thyroid hormones in rats. the study was carried out on 40 sprague-dawley male rats. the rats were equally allocated to four groups: group 1 (control group), group 2 (zinc-deficient group), group 3 (pinealectomized group) and group 4 (pinealectomized and zinc-deficient group). at the end of a 4-week study period, the rats were decapitated and blood samples were taken. the samp ... | 2003 | 14682476 |
| [agranulocytosis and acute coronary syndrome in apathetic hyperthyroidism]. | tissue expose to excessive levels of circulating thyroid hormones results in thyrotoxicosis. in most cases, thyrotoxicosis is due to hyperactivity of the thyroid gland. cardiovascular and myopathic manifestations are predominant clinical features in most hyperthyroid patients, aged 60 years and older. some of patients have apathetic hyperthyroidism which presents with weight loss, small goiter, severe depression and without clinical features of increased sympathetic activity [3, 6]. about 50% of ... | 2003 | 14692133 |
| the combined effects of trigonella and allium extracts in the regulation of hyperthyroidism in rats. | the combined effects of trigonella foenum-graecum and allium sativum extracts were evaluated for their ameliorative potential in the l-thyroxine-induced hyperthyroidic rat model to contribute to an understanding of interaction between the two extracts. the investigation was carried out using two different doses. a comparison was made with the response of individual plant extracts at the previously studied effective dose in adult wistar rats rendered hyperthyroidic by daily injections of l-thyrox ... | 2003 | 14692727 |
| cd4 is expressed by epidermal langerhans' cells predominantly as covalent dimers. | langerhans' cells (lc) of skin are cd4 expressing, dendritic, antigen-presenting cells, that are essential for activation of primary immune responses and are productively infected by hiv. we have shown previously that lymphocytes and monocytes express cd4 both as monomers and covalently linked homodimers. in those cells the 55-kda monomer structure predominates. lc in un-fractionated human epidermal cell (ec) suspension also expresses both forms of cd4, but in ec the dimer form is predominant. b ... | 2003 | 14705812 |
| the effect of propranolol, atenolol and metoprolol on the serum levels of thyroxin (t4) and triiodothyronine (t3). | 2003 | 14699907 | |
| chronic daily ethanol and withdrawal: 5. diurnal effects on plasma thyroid hormone levels. | we previously demonstrated that chronic daily ethanol consumption and daily withdrawal by male rats in a modified ethanol liquid diet paradigm produced (a) chronically increased adrenal glucocorticoid activity; (b) decreased plasma testosterone; (c) decreased forebrain proopiomelanocortin gene expression; and (d) corresponding alterations in plasma leptin levels-all of which are consistent with reported changes during alcohol abuse and alcoholism. each of these systems interact with hypothalamo- ... | 2003 | 14709806 |
| intellectual development and thyroid function in children who were breast-fed by thyrotoxic mothers taking methimazole. | recent studies have shown normal thyroid function in infants whose mothers receive methimazole (mmi) during breast-feeding. this study evaluates the long-term effect of mmi on thyroid function and intellectual development of such children. | 2003 | 14714745 |
| importance of internal mammary artery perfusion in cardiac ischemia and reperfusion. | our purpose was to investigate the changes in antioxidant defense systems due to internal mammary artery (ima) perfusion during coronary artery bypass graft (cabg) operations in which proximal anastomoses were completed under partial bypass with the aid of a side-biting clamp. | 2003 | 14714770 |
| a short latency vestibular evoked potential (vsep) produced by bone-conducted acoustic stimulation. | in this paper data are presented from an experiment which provides evidence for the existence of a short latency, acoustically evoked potential of probable vestibular origin. the experiment was conducted in two phases using bone-conducted acoustic stimulation. in the first phase subjects were stimulated with 6-ms, 500-hz tone bursts in order to obtain the threshold v(t) for vestibular evoked myogenic potentials (vemp). it was confirmed that the difference between bone-conducted auditory and acou ... | 2003 | 14714807 |
| [possible consequences of subclinical hypothyroidism]. | subclinical hypothyroidism is defined as elevated tsh in the presence of normal free t4 and t3 levels. this review discusses the following questions concerning subclinical hypothyroidism that have not been solved yet: 1) does elevated tsh always mean failure of the thyroid gland? 2) do patients with subclinical hypothyroidism always develop overt hypothyroidism? 3) are they symptomatic? 4) does treatment with l-thyroxine cure these symptoms,--if they exist? summarizing the results of the literat ... | 2003 | 14710477 |
| prevalence of thyroid disorders in pregnant women with mild iodine deficiency. | to assess the prevalence of thyroid disorders in a region with mild iodine deficiency, this study was undertaken in a randomized sample of pregnant women during different gestational periods. evaluations were performed in 215 women: thyroid ultrasound scanning, thyroid stimulating hormone (tsh), free thyroxine (t4) and thyroid peroxidase (tpo) antibodies. at the time of participation in the study, some women (90/215) had been receiving 150-200 micrograms iodine. hypothyroidism was found in four ... | 2003 | 14710590 |
| skeletonizing en-bloc gastrectomy for adenocarcinoma in caucasian patients. | the prognostic relevance of a japanese-like lymphadenectomy for gastric adenocarcinoma is caucasian patients is not well establishes. | 2003 | 14716514 |
| laparoscopy significantly improves the perceived preoperative stage of gastric cancer. | the aim of this study was to examine the accuracy of laparoscopy is staging patients with gastric cancer in comparison with preoperative computed tomography (ct) examination. | 2003 | 14716516 |
| effects of methionine deficiencies on plasma levels of thyroid hormones, insulin-like growth factors-i and -ii, liver and body weights, and feed intake in growing chickens. | we showed previously that met deficiency at 0.25% of the diet causes elevations in plasma triiodothyronine (t3) in broilers. in the present study, plasma levels of thyroid hormones as well as insulin-like growth factors (igf)-i and -ii were measured in chicks fed 3 deficient levels of total met. control (0.5%) and met-deficient diets (0.4, 0.3, and 0.2%) were fed to male broilers from 8 to 22 d of age. additional groups of control chicks were pair-fed with the met-deficient ones. chicks receivin ... | 2003 | 14717551 |
| effects of turning duration during incubation on corticosterone and thyroid hormone levels, gas pressures in air cell, chick quality, and juvenile growth. | two peaks of embryo mortality have been identified during incubation of chicken eggs (the first and the final phases of incubation), and both are linked to egg turning. turning in the first week enables proper formation of extra-embryonic membrane and in the final week avoids embryo malpositioning. the hatchability of the eggs, however, may depend on physiological parameters (e.g., hormone levels or gas pressures) that turning may influence to ensure proper embryo development and survival. it is ... | 2003 | 14717556 |
| [laparoscopic surgery of the stomach: state of the art]. | over the past 10 years laparoscopy has been used for the staging of gastric cancer. it has also been used over the past decade for cancer resections, mainly stage i. in addition, it can be used for palliation in advanced stages. we have reviewed the main papers published in the english literature with a view to assessing the validity of laparoscopy in the staging of gastric cancer and in curative resections for cancer. several studies published in the last 5 years have demonstrated the utility o ... | 2003 | 14725220 |
| [ethmoid adenocarcinoma: a series of 17 cases]. | ethmoid adenocarcinoma are and represent rare, 2.5 to 3% of head and neck cancers. the 5-year survival is around 50% for all stages. we present a series of 17 patients treated in our institution. | 2003 | 14726849 |
| [effect of local immunotherapy of interleukin 2(il-2) in combination with chemotherapy upon intratumoral lymphocytes in oral squamous cell carcinomas]. | to evaluate the effect of locoregional immunotherapy of interleukin 2 (il-2) in combination with chemotherapy upon intratumoral lymphocytes in oral squamous cell carcinomas. | 2003 | 14732977 |
| [hypothyroidism in dizygotic premature twins due to excessive prepartal vaginal iodine application]. | in dizygotic premature twins delivered by caesarean section after prolonged efforts to effect premature birth we found markedly enhanced thyroid stimulating hormone levels. the mother had been subjected to local polyvidone iodine therapy for seven weeks with pvp suppositories to prevent vaginal infections. control checks revealed persistently elevated tsh levels, whereas t3/t4 levels were always reduced. greatly pronounced iodine excretion was seen in the urine of both the babies. this raised th ... | 2003 | 14556121 |
| regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (monodelphis domestica). | these studies define the time table and origin of supraspinal axons regenerating across a complete spinal transection in postnatal monodelphis domestica. after lumbar (l1) spinal cord injection of fluorophore-dextran amine conjugate on postnatal (p) day 4, a consistent number of neurons could be labeled. the numbers of labeled neurons remained stable for several weeks, but subsequently declined by p60 in control animals and by p35 in animals with complete spinal transection (t4-t6) performed at ... | 2003 | 14556298 |
| viability of the antigen determines whether dna or urocanic acid act as initiator molecules for uv-induced suppression of delayed-type hypersensitivity. | uv radiation suppresses the immune response, and uv-induced immune suppression contributes to uv-induced photocarcinogenesis. for uv-induced immune suppression to occur, electromagnetic energy (i.e. uv radiation) must be converted to a biological signal. two photoreceptors have been identified in the skin that serves this purpose, epidermal dna and trans-urocanic acid (uca). although compelling evidence exists to support a role for each pathway (uv-induced dna damage or photoisomerization of uca ... | 2003 | 14556308 |
| does a combination regimen of thyroxine (t4) and 3,5,3'-triiodothyronine improve depressive symptoms better than t4 alone in patients with hypothyroidism? results of a double-blind, randomized, controlled trial. | some hypothyroid patients receiving levothyroxine replacement therapy complain of depressive symptoms despite normal tsh measurements. it is not known whether adding t(3) can reverse such symptoms. we randomized 40 individuals with depressive symptoms who were taking a stable dose of levothyroxine for treatment of hypothyroidism (excluding those who underwent thyroidectomy or radioactive iodine ablation of the thyroid) to receive t(4) plus placebo or the combination of t(4) plus t(3) in a double ... | 2003 | 14557420 |
| genetically targeted adenovirus vector directed to cd40-expressing cells. | the success of gene therapy depends on the specificity of transgene delivery by therapeutic vectors. the present study describes the use of an adenovirus (ad) fiber replacement strategy for genetic targeting of the virus to human cd40, which is expressed by a variety of diseased tissues. the tropism of the virus was modified by the incorporation into its capsid of a protein chimera comprising structural domains of three different proteins: the ad serotype 5 fiber, phage t4 fibritin, and the huma ... | 2003 | 14557622 |
| evaluation of intense neuromuscular blockade caused by rocuronium using posttetanic count in male and female patients. | to establish the relationship between train-of-four (tof) nerve stimulation and the number of posttetanic twitches (posttetanic count [ptc]) during neuromuscular blockade caused by rocuronium in males and females. | 2003 | 14652123 |
| alterations in the mitochondrial displacement loop in lung cancers. | alterations of the noncoding displacement (d) loop of mitochondrial dna are present in many cancers. these alterations include numerical changes in a homopolymeric c tract (pct) at positions 303-309 and single base substitutions (sbs). we determined the frequency of d-loop alterations in lung cancer cell lines and tumors, and related them to clinicopathologic features. | 2003 | 14654546 |
| discovery and characterization of a thermostable bacteriophage rna ligase homologous to t4 rna ligase 1. | thermophilic viruses represent a novel source of genetic material and enzymes with great potential for use in biotechnology. we have isolated a number of thermophilic viruses from geothermal areas in iceland, and by combining high throughput genome sequencing and state of the art bioinformatics we have identified a number of genes with potential use in biotechnology. we have also demonstrated the existence of thermostable counterparts of previously known bacteriophage enzymes. here we describe a ... | 2003 | 14654700 |
| virus inactivation in aluminum and polyaluminum coagulation. | inorganic aluminum salts, such as aluminum sulfate, are coagulants that cause small particles, such as bacteria and viruses as well as inorganic particles, to destabilize and combine into larger aggregates. in this investigation, batch coagulation treatments of water samples spiked with qbeta, ms2, t4, and p1 viruses were conducted with four different aluminum coagulants. the total infectious virus concentration in the suspension of floc particles that eventually formed by dosing with coagulant ... | 2003 | 14655704 |
| the structure of escherichia coli rusa endonuclease reveals a new holliday junction dna binding fold. | holliday junction resolution performed by a variety of structure-specific endonucleases is a key step in dna recombination and repair. it is believed that all resolvases carry out their reaction chemistries in a similar fashion, utilizing a divalent cation to facilitate the hydrolysis of the phosphodiester backbone of the dna, but their architecture varies. to date, with the exception of bacteriophage t4 endonuclease vii, each of the known resolvase enzyme structures has been categorized into on ... | 2003 | 14656440 |
| separation and recovery of dna fragments by electrophoresis through a thermoreversible hydrogel composed of poly(ethylene oxide) and poly(propylene oxide). | we have synthesized and characterized a thermoreversible hydrogel of multiplied block copolymers, composed of poly(ethylene oxide) and poly(propylene oxide), for dna electrophoresis. the aqueous solution of block copolymers turned into a hydrogel upon heating at temperatures above 10-11 degrees c, whereas it reverted into a solution upon cooling. linear double-stranded dna molecules migrated through the gel matrices at a rate that was inversely proportional to the logarithm of the dna length. th ... | 2003 | 14656528 |
| serum interleukin-18 and nitric oxide activity in bladder carcinoma. | both interleukin-18 and nitric oxide are multifunctional molecules that are involved in the different steps of carcinogenesis. | 2003 | 14656691 |
| update on locally advanced breast cancer. | locally advanced breast cancer remains a clinical challenge as the majority of patients with this diagnosis develop distant metastases despite appropriate therapy. patients with locally advanced disease encompass a wide range of clinical scenarios including advanced primary tumors (stage t4), advanced nodal disease (fixed axillary nodes or involvement of ipsilateral supraclavicular, infraclavicular, or internal mammary nodes), and inflammatory carcinomas. the prognoses of women with locally adva ... | 2003 | 14657530 |
| preoperative systemic treatment: prediction of responsiveness. | the use of predictive factors allows a more effective use of available therapies by enabling clinicians to distinguish patients likely to obtain substantial benefit from treatment from those for whom the same therapy is less likely to be effective. a most relevant aspect of clinical research is thus to develop alternative therapeutic approaches which are more efficacious for this latter group, particularly important since treatment effects are likely to be small. in the preoperative setting seve ... | 2003 | 14659132 |
| effects of osteoporotic cytokines in ovary-intact and ovariectomised rats with induced hyperthyroidism; is skeletal responsiveness to thyroid hormone altered in estrogen deficiency? | this experimental study was designed to examine the effects of hyperthyroidism on osteoporotic cytokines such as interleukin (il)-1beta, il-6 and tumor necrosis factor (tnf)-alpha in the physiological concentrations and in the deficiency of estrogen. we investigated the effects of thyroid hormones on cytokines and bone metabolism in l-thyroxine induced ovary-intact and ovariectomised rats, as levels of cytokines were increased in hyperthyroidism. the rats were divided into three groups. in the f ... | 2003 | 14626509 |
| effect of donepezil on eeg spectral analysis in alzheimer's disease. | eeg spectral analysis allows a quantitative analysis of changes in the frequency bands during disease progression in alzheimer's disease (ad) and could be used to monitor treatment and disease progression. eighteen patients with probable ad were evaluated by folstein mini mental state examination (mmse) and eeg spectral analysis before donepezil treatment, 2 months after 5 mg/day and 4 months after the dose was raised to 10 mg/day. eeg evaluations were done in 4 derivations (t3-t5, t4-t6, c3-p3, ... | 2003 | 14626697 |
| thick melanoma in the elderly. | the objective of this analysis is to ascertain the natural history of elderly patients greater than 65 years of age with thick melanoma (t4) who were treated with surgery only. although there are multiple data on elderly patients, there is not a systematic review of survival in elderly patients over 65 years, and with our analysis we tried to enlighten this field in view especially of the growing population of the elderly in the united states. we retrospectively evaluated 112 patients with thick ... | 2003 | 14627262 |
| a novel approach to describe a u1 snrna binding site. | rna duplex formation between u1 snrna and a splice donor (sd) site can protect pre-mrna from degradation prior to splicing and initiates formation of the spliceosome. this process was monitored, using sub-genomic hiv-1 expression vectors, by expression analysis of the glycoprotein env, whose formation critically depends on functional sd4. we systematically derived a hydrogen bond model for the complementarity between the free 5' end of u1 snrna and 5' splice sites and numerous mutations followin ... | 2003 | 14627829 |
| real-time monitoring of nucleic acid ligation in homogenous solutions using molecular beacons. | nucleic acids ligation is a vital process in the repair, replication and recombination of nucleic acids. traditionally, it is assayed by denatured gel electrophoresis and autoradiography, which are not sensitive, and are complex and discontinuous. here we report a new approach for ligation monitoring using molecular beacon dna probes. the molecular beacon, designed in such a way that its sequence is complementary with the product of the ligation process, is used to monitor the nucleic acid ligat ... | 2003 | 14627838 |
| hypofractionated conformal radiotherapy in carcinoma of the prostate: five-year outcome analysis. | recent publications have indicated that the alpha/beta ratios for carcinoma of the prostate are much lower than had originally been thought, suggesting that prostate cancer may be highly sensitive to fraction size. we have reviewed our unique experience of the use of 3.13 gy fractions in a large cohort of men treated homogeneously in a single institute. | 2003 | 14630259 |
| acanthamoeba keratitis update-incidence, molecular epidemiology and new drugs for treatment. | a reliable figure for the expected incidence of acanthamoeba keratitis of one per 30000 contact lens wearers per year has now been obtained from a combination of three cohort and three questionnaire reporting surveys; 88% of cases wore hydrogel lenses and 12% wore rigid lenses. this figure now provides a basis for the expected number of cases against which to judge either epidemic outbreaks or effects of prevention with disinfecting solutions, better hygiene, or the use of disposable lenses. mol ... | 2003 | 14631394 |
| health-related quality of life after radical prostatectomy in japanese men with localized prostate cancer. | we evaluated retrospectively health-related quality of life (hrqol) after radical prostatectomy (rp) in japanese men with localized prostate cancer. | 2003 | 14633067 |
| effect of non-steroidal aromatase inhibitor on blood plasma ovarian steroid and thyroid hormones in laying hen (gallus domesticus). | hyline brown laying hens at 30 weeks of age were treated twice daily with fadrozole, a non-steroidal aromatase inhibitor (ai; 1 mg/kg body weight; i.m.) for six consecutive days; control hens received saline. blood was collected every day 0.5 h after oviposition, i.e. just before ai treatment. ovarian steroids: progesterone (p4), testosterone (t) and estradiol (e2), and iodothyronines: thyroxine (t4), triiodothyronine (t3) and reverse-triiodothyronine (rt3) were measured in blood plasma by radio ... | 2003 | 14633224 |
| the effect of right versus left lateral decubitus positions on induction of spinal anesthesia for cesarean delivery. | induction of spinal anesthesia for cesarean delivery in the left lateral (ll) decubitus position combined with intraoperative left uterine displacement may result in pooling of local anesthetic onto one side of the body. we studied the effect of the right lateral (rl) and ll decubitus positions during placement of spinal anesthesia on the intrathecal spread of 0.5% hyperbaric bupivacaine plus fentanyl in 60 term parturients. though all parturients acquired a loss of cold sensation at t4 15 min a ... | 2003 | 14633562 |