Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| coexpression of interleukin-4 and b7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant. | to improve the vaccine potency of gene-modified tumor cells, using retroviruses, we have expressed the b7.1 gene in j558l cells and a subline previously transfected with the gene for interleukin-4 (il-4). complete longterm tumor eradication occurred in only 73-82% of syngeneic balb/c mice injected with il-4 or b7.1 transfectants or tumor cells mixed with the adjuvant corynebacterium parvum. in contrast, none of the mice injected with j558-il4/b7.1 cells developed a tumor, thus demonstrating that ... | 1996 | 8800747 |
| susceptibility testing of propionibacterium acnes comparing agar dilution with e test. | propionibacterium acnes has been identified as a significant agent of nosocomial infections, including endophthalmitis. data concerning susceptibility of p. acnes to newer beta-lactam antibiotics and fluoroquinolones are limited. recent reports suggest that quinolones have activity against these organisms sufficient to warrant further study. we undertook a study to select appropriate antimicrobial agents for use in a rabbit model of p. acnes endophthalmitis. we compared the antibiotic susceptibi ... | 1996 | 8815076 |
| failure of gram stain to detect propionibacterium acnes in specimens from clinically significant infections. | 1996 | 8818915 | |
| propionibacterium acnes isolated from sternal osteitis in a patient with sapho syndrome. | a woman presented with palmar pustulosis and deep chest pain in association with osteitic lesions in the lower part of the sternum. propionibacterium acnes was isolated and grew in pure culture from 6 surgically obtained bone specimens. the patient received clindamycin treatment for 6 months. synovitis in both her wrists persisted and, based on a clinical suspicion of seronegative rheumatoid arthritis, she was treated with intramuscular gold and methotrexate with no apparent benefit. subsequentl ... | 1996 | 8823714 |
| critical comments on "propionibacterium acnes in the cortex of patients with alzheimer's disease" by h.h. kornhuber (eur arch psychiatry clin neurosci, 1996, 246:108-109) | 1996 | 8832202 | |
| role of ifn gamma on tnf alpha, il-1 beta and il-6 release during hhv-6 infection. | the release of monokines such as tumor necrosis factor a (tnf alpha), interleukin-1 beta (il-1 beta) and interleukin-6 (il-6) by activated monocytes/macrophages is an important step in the immune as well as in the inflammatory response. in this study the production of tnf alpha, il-1 beta and il-6 by human monocytes (hm) and peripheral blood mononuclear cells (pbmc) was evaluated after hhv-6 infection. our results demonstrate that hhv-6 can selectively regulate monokine synthesis, in a time-depe ... | 1996 | 8841033 |
| orbital infections in patients with human immunodeficiency virus infection. | opportunistic infections frequently involve the anterior and posterior segments of the eye but rarely occur in the orbit in patients with human immunodeficiency virus (hiv) infection. the authors managed eight patients with hiv and unilateral orbital infections who presented between july 1988 and march 1995. | 1996 | 8841310 |
| infection of a total knee joint prosthesis by peptostreptococcus micros and propionibacterium acnes in an elderly ra patient: implant salvage with longterm antibiotics and needle aspiration/irrigation. | we describe the favourable long-term outcome after late total knee joint prosthesis infection in an elderly ra patient. peptostreptococcus micros and propionibacterium acnes were cultured from the synovial fluid, and the finding of a coexistent abscess at the root of a wisdom tooth suggested a dental origin to the joint infection. long-term antibiotics in conjunction with aspiration/irrigation resulted in salvage of the implant and an excellent functional outcome. | 1996 | 8853177 |
| protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries. | hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of celosia argentea, was investigated using chemical and immunological liver injury models. celosian inhibited the elevation of serum enzyme (gpt, got, ldh) and bilirubin levels on carbon tetrachloride (cc1(4))-induced liver injuries in rat. in addition, the hepatoprotective effect of celosian was also observed in this model of liver injury by histopathological findings. moreover, celosian s ... | 1996 | 8860960 |
| experimental extrinsic allergic alveolitis and pulmonary angiitis induced by intratracheal or intravenous challenge with corynebacterium parvum in sensitized rats. | extrinsic allergic alveolitis and pulmonary sarcoidosis are granulomatous diseases of the lung for which clinical presentation and anatomic site of granuloma formation differ. extrinsic allergic alveolitis is caused by inhaled antigens, whereas the nature and source of the inciting antigen in sarcoidosis is unknown. to test the hypothesis that the route via which antigen is introduced to the lung contributes to the clinicopathological presentation of pulmonary granulomatous disease, rats immuniz ... | 1996 | 8863677 |
| influence of hemodilution on cefuroxime levels and bacterial contamination of intra- and postoperative processed wound blood during hip replacement. | materials and methods: in a prospective randomized study we investigated the effect of hemodilution on cefuroxime levels and bacterial contamination of processed shed blood during hip arthroplasty. 10 patients received cefuroxime 1,5 g as single shot prophylaxis before (group a), 10 after hemodilution (15 ml/kg) (group b). cefuroxime levels in serum 1 h after administration, at the end of operation, after 12 h and in drainage-blood after 12 h were assessed by hplc. bacteriological study was perf ... | 1996 | 8865946 |
| intervertebral diskitis caused by propionibacterium acnes: a report of four cases. | 1996 | 8879798 | |
| ifn-gamma-inducing factor up-regulates fas ligand-mediated cytotoxic activity of murine natural killer cell clones. | nk cells, non-t non-b immune effector lymphocytes, are localized in many organs, including liver, as well as in the circulation. to investigate the regulatory mechanism of killing apparatus in hepatic nk cells, we established il-2-dependent nk cell clones from liver lymphocytes of balb/c nude mice. to generate the nk cell clones, we incubated liver lymphocytes with a high dose of il-2 in the presence of irradiated kupffer cells, as feeder cells and as the source of il-12, originally identified a ... | 1996 | 8892629 |
| sub-species discrimination, using pyrolysis mass spectrometry and self-organising neural networks, of propionibacterium acnes isolated from normal human skin. | curie-point pyrolysis mass spectra were obtained from 30 propionibacterium acnes strains isolated from the foreheads of six healthy humans. multivariate analyses and kohonen artificial neural networks (kanns), employing unsupervised learning, were used successfully to discriminate between the p.acnes isolates from different individual hosts. the classification of the isolates by kanns was compared with the more classical multivariate techniques of canonical variates analysis and hierarchical clu ... | 1996 | 8899970 |
| susceptibility to immunologically mediated fatigue in c57bl/6 versus balb/c mice. | proinflammatory cytokines such as interleukin (il)-1 and tumor necrosis factor (tnf)-alpha have been proposed to play a role in the pathogenesis of fatigue. in the present study we compared the susceptibility of two mouse strains to immunologically induced fatigue. daily running of two strains of mice, balb/c and c57bl/ 6, was assessed after a single injection of corynebacterium parvum antigen (2 mg/mouse). spontaneous running activity of each animal was compared to mean running distance prior t ... | 1996 | 8906747 |
| administration of interleukin-10 at the time of priming protects corynebacterium parvum-primed mice against lps- and tnf-alpha-induced lethality. | several laboratories have described the protective effects of interleukin-10 (il-10) in mouse models of lethal endotoxemia. in most of these experiments, protection was observed in normal mice that were given a lethal dose of lps. however, we failed to observe protection with il-10 in lps-challenged mice that had been primed with corynebacterium parvum (proprionibacterium acnes). we have extended our studies with il-10 in c. parvum-primed mice and in some cases have observed protection that appe ... | 1996 | 8912878 |
| mycotic aneurysm after aortic bifurcation prosthesis. | fever in the presence of an intravascular graft will focus the clinical investigation on an infection of this graft. this case report describes an uncommon cause of fever in a 75-year-old patient, namely a mycotic aneurysm of the aortic stump. | 1996 | 8935752 |
| degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from porphyromonas gingivalis and treponema denticola. | bacterial proteases may participate in the pathogenesis of periodontal diseases through their action on host proteins. in the present study, the ability of selected periodontopathogens, as well as two proteases isolated from porphyromonas gingivalis and treponema denticola, to degrade host protease inhibitors was evaluated. the activation of human plasminogen by the two bacterial proteases was also investigated. proteolytic breakdown of host protease inhibitors (alpha-1-antitrypsin, antichymotry ... | 1996 | 8936322 |
| microbial evaluation: 139 implants removed from symptomatic patients. | possible adverse effects of microbial organisms have been implicated in symptomatic silicone implant patients. in the literature, numerous authors have investigated the possible role of infection with respect to implant problems. to date, various bacterial species have been reported, including staphylococcus aureus, staphylococcus epidermidis, peptostreptococci, and clostridium perfringens. infections in polyurethane-coated prostheses also have been shown to prolong morbidity. antibiotic use has ... | 1996 | 8942908 |
| corynebacterium parvum- and mycobacterium bovis bacillus calmette-guerin-induced granuloma formation is inhibited in tnf receptor i (tnf-ri) knockout mice and by treatment with soluble tnf-ri. | the aim of this study was to examine the role of tnf receptor i (tnf-ri) in the pathogenesis of heat-killed corynebacterium parvum- and live bacillus calmette-guerin (bcg)-induced granulomas. granuloma formation was analyzed in tnf-ri knockout mice and after treatment with soluble tnf-ri (stnf-ri). tnf-ri knockout mice injected with c. parvum or bcg developed fewer and smaller granulomas than wild-type control mice. mice treated with stnf-ri from days 7 to 13 after injection of c. parvum or bcg ... | 1996 | 8943410 |
| use of fura-2/am to measure intracellular free calcium in selenomonas ruminantium. | this paper describes a procedure for loading the acetoxymethyl ester of fura-2 (fura-2/am), and the subsequent measurement of the concentration of intracellular free ca2+ ([ca2+]i) in selenomonas ruminantium (s. ruminantium) using this technique. to ascertain the optimal loading conditions, the effect was examined on the loading of fura-2/am of ethylenediamine-tetraacetic acid (edta), lysozyme, pluronic f127 alone, or the simultaneous application of edta and pluronic f127. individual administrat ... | 1996 | 8944431 |
| sensitivity of propionibacterium acnes isolated from acne patients: comparative study of antimicrobial agents. | the antimicrobial susceptibility of propionibacterium acnes isolated before and after treatment of acne patients was measured. the four female and three male acne patients were treated with an oral acne medication, roxithromycin or minocycline, and/or a topical acne medication, nadifloxacin cream or clindamycin hydrochloride lotion for 1-8 weeks. the isolated strains were tested for their susceptibility to the antimicrobial action of: nadifloxacin, ofloxacin, erythromycin, clindamycin hydrochlor ... | 1996 | 8959531 |
| [roles of inflammatory cells in the pathogenesis of acute lung injury in guinea pigs exposed to heat-killed bacteria]. | to study the contribution of polymorphonuclear (pmn) and mononuclear (mn) phagocytes to the development of acute lung injury, we studied lung injury after intratracheal instillation of lipopolysaccharide (0.02 mg/kg) in guinea pigs previously exposed to heat-killed corynebacterium parvum. in on group, cyclophosphamide was given to deplete peripheral pmns. in another group, gadolinium chloride (gdcl3) was injected to suppress the function of mns. four hours after instillation of lippoly soccharid ... | 1996 | 8965395 |
| bacterial immunomodulator olimunostim inhibits degranulation of mastocytes in vitro. | a bacterial immunomodulator olimunostim (os) is one of the first czech biologic response modifiers, which have been introduced into clinical practice. os activates the mechanisms of non-specific immunity and is used for the most part in chronic infections. since os is indicated in patients suffering from infection complicated allergic diseases (asthma bronchiale, atopic eczema, etc.), (1) the concentration of histamine (hi) and hi-like compounds in os, and (2) the possible role of os in the proc ... | 1996 | 8997641 |
| propionibacterium acnes in the cortex of patients with alzheimer's disease. | propionibacterium acnes was found in the cortex of three patients with alzheimer's disease and in one frontal cortex of an elderly patient with cardiovascular risk factors and hypoxia due to a large glioblastoma of the right frontal lobe with severely increased intracranial pressure. propionibacterium acnes is an atypical anaerobic bacterium which is sensitive to cephalosporins, but insensitive to metronidazole. it is concluded that a capillary microangiopathy (in consequence of old age and card ... | 1996 | 9063907 |
| fluorescence photography in the evaluation of acne. | quantification of acne remains a challenge. it may be difficult to identify lesions by standard flash photography. previous studies have shown that foci of light in fluorescence photographs correspond to high protoporphyrin ix production by propionibacterium acnes in open comedones, follicles, and inflammatory lesions. | 1996 | 8682965 |
| [current treatment strategy in malignant pleural effusion]. | malignant pleural effusions are a grave consequence of advanced cancer disease. the successful suppression of pleural fluid reaccumulation can make a major contribution to the management and palliative care of patients with disseminated cancer. many treatment concepts have been reported in the literature. the recommended therapy in malignant pleural effusions consists of intrapleural instillation of a sclerotic agent to produce pleurodesis. different substances have been used, including tetracyc ... | 1996 | 8686317 |
| singlet oxygen (1 delta g) generation from coproporphyrin in propionibacterium acnes on irradiation. | although singlet oxygen has been postulated to be a highly reactive and toxic intermediate, there has been no evidence of considerable generation of singlet oxygen in vivo level except for special cases. in this work, we firstly measured the near-infrared emission spectra corresponding to the o2(1 delta g) --> o2(3 epsilon g-) transition of singlet oxygen of cutaneous propionibacterium acnes (p. acnes) porphyrin under laser excitation. a comparison of the singlet oxygen production of coproporphy ... | 1996 | 8687438 |
| salivacin 140, a novel bacteriocin from lactobacillus salivarius subsp. salicinius t140 active against pathogenic bacteria. | fifteen of 353 environmental isolates of lactic acid bacteria consistently showed activity against listeria monocytogenes, streptococcus mutans, actinomyces viscosus, and/or propionibacterium acnes. strain t140, isolated from the surface of japanese pampas grass leaves and identified as lactobacillus salivarius subsp. salicinius, also had activity against several lactobacillus species, staphylococcus aureus and yersinia enterocolitica. since the antagonistic factor(s) produced by t140 was sensit ... | 1996 | 8695066 |
| effect of silica treatment on resistance to babesia rodhaini infection in immunized mice. | the effect of silica treatment on the course of babesia rodhaini infection was investigated in icr mice pretreated with either a mixture of b. rodhaini parasitized red blood cell hemolysation-sonication (s) antigen and propionibacterium acnes bacterin or p. acnes bacterin alone and not subjected to immunization. in the normal mice (non-immunized), the mean survival time was decreased by approximately 1 day when 5 mg per mouse of silica were intraperitoneally inoculated at 5 h before infection. i ... | 1996 | 8720558 |
| bacterial contamination of anaerobic vitreous cultures: using techniques employed for endophthalmitis. | to investigate the occurrence of contaminated cultures of vitreous specimens from non-infected eyes obtained using anaerobic techniques employed for endophthalmitis. | 1996 | 8670775 |
| a pivotal role of il-12 in th1-dependent mouse liver injury. | intravenous injection of propionibacterium acnes and lipopolysaccharide (lps) with a 7 day interval caused cd4+ t cell-dependent severe liver injury in the c57bl/6 (h-2b) mouse strain. in contrast, balb/c (h-2d) mice were resistant to p. acnes and lps-induced liver injury. the different susceptibilities of the two mouse strains to liver injury appeared to be closely correlated with their different abilities to produce ifn-gamma after p. acnes priming. namely, the sensitive c57bl/6 mouse strain p ... | 1996 | 8671644 |
| anti-lipase activity of kampo formulations, coptidis rhizoma and its alkaloids against propionibacterium acnes. | anti-lipase activity of kampo formulations, coptidis rhizoma (cr), and its alkaloids against propionibacterium acnes were examined in vitro. the amounts of propionic and butyric acids in the medium were measured as growth and lipase activity of p. acnes, respectively. in tributyrin-pyg medium with each concentration of kampo formulation, cr, or the alkaloids added, the production of propionic acid was suppressed remarkably more than that of butyric acid. the suppression of production of these ac ... | 1996 | 8675819 |
| [positive corneal findings of propioni bacterium acnes and keratitis]. | propioni bacterium acnes may be isolated from corneal specimens. its presence usually evokes a neighbouring tissue contamination. nevertheless we have tried to find arguments in favour of a possible pathological responsibility of this microorganism in corneal affections. | 1996 | 8729835 |
| activity of eleven kampo formulations and eight kampo crude drugs against propionibacterium acnes isolated from acne patients: retrospective evaluation in 1990 and 1995. | we reviewed the susceptibility of propionibacterium acnes to eleven kampo formulations and to eight kampo crude drugs that had been studied by examining their minimum inhibitory concentrations (mic) in 1990 and 1995. p. acnes strains were most sensitive to oren-gedoku-to (ogt) among these kampo formulations. coptidis rhizoma (cr) and phellodendri cortex (pc) inhibited the growth of p. acnes significantly among the eight kampo crude drugs examined. the patterns of distribution of mic of kampo for ... | 1996 | 9037918 |
| presumed noninfectious endophthalmitis after cataract surgery. | to study the clinical features and results of conservative management in cases of presumed noninfectious endophthalmitis after cataract surgery. | 1996 | 9051508 |
| electrophoresis of whole-cell soluble proteins of microorganisms isolated from bacteremias in endodontic therapy. | we have previously demonstrated that anaerobic bacteria are the microorganisms most frequently isolated from blood following endodontic therapy of teeth with apical periodontitis. phenotypic characterisation of the isolates suggested that the bacteria in the blood originated from the root canal. the present experiment using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) was carried out in an effort to verify these findings, and to further study the microorganisms involved i ... | 1996 | 9021323 |
| effects of non-specific immunopotentiators in experimental schistosoma mansoni infection. ii. corynebacterium parvum. | the effects of corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in schistosoma mansoni infected mice were studied. the c. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). the host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.01 ... | 1996 | 9293078 |
| pleural malignancies. | carcinoma of the lung, metastatic breast carcinoma, and lymphoma are responsible for approximately 75% of all malignant pleural effusions. the presence of malignant cells in the pleural fluid or in the parietal pleura confirms the diagnosis. recently, several authors have proposed the combination of morphometric procedures and quantitative analysis of nucleolar organizer regions stained by silver nitrate. videothoracoscopy is recommended for patients suspected of having a malignant pleural effus ... | 1996 | 9363162 |
| severe infections caused by propionibacterium acnes: an underestimated pathogen in late postoperative infections. | propionibacterium acnes belongs to the cutaneous flora of humans and is rarely considered a pathogen in human diseases. it is a frequent contaminant in blood cultures; however, in some patients it has been identified as the causative agent of life-threatening infections. within the last years we have observed an abrupt increase in severe p. acnes infections which prompted us to study in detail the clinical and microbiological features, risk factors, and outcomes of these cases. in a retrospectiv ... | 1996 | 9436290 |
| [effect of silymarin on mouse liver damage, production and activity of tumor necrosis factor]. | tumor necrosis factor (tnf) has been well-characterized as a prominent mediator in the development of liver injury. effects of silymarin (sb) on mouse liver damage, tnf production and activity were studied. pretreatment with sb (25-50 mg.kg-1, i.p., bid x 3 d) before the lipopolysaccharides (lps) injection markedly alleviated liver injury and diminished lps-induced tnf production in propionibacterium acnes (pa)-primed mice. sb (12.5-50 micrograms.ml-1) significantly inhibited lps-induced tnf rel ... | 1996 | 9772703 |
| [effect of matrine on mouse hepatitis and tumor necrosis factor production induced by propionibacterium acnes/lipopolysaccharides]. | the effect of matrine (mat) on lipopolysaccharides (lps)-induced fatal hepatitis and tumor necrosis factor (tnf) production in propionibacterium acnes (pa)-primed mice were studied. mice were injected i.p. lps (10 micrograms/mouse) 7 d after i.p. pa (0.5 ml/mouse) to induce fatal hepatitis. after i.p. lps, serum tnf activity rose to 1657 +/- 406 ku.l-1 at 1.5 h and alt activity increased up to 1,496 +/- 890 u.l-1 at 5 h. six of 8 mice died within 5 h and the massive hemorrhagic necrosis of the l ... | 1996 | 9863231 |
| aerobic and anaerobic microbiology of superficial suppurative thrombophlebitis. | to study the aerobic and anaerobic microbiologic characteristics of superficial suppurative thrombophlebitis. | 1996 | 8546586 |
| role of adhesion molecules in the development of massive hepatic necrosis in rats. | massive hepatic necrosis develops after endotoxin administration in rats pretreated with heat-killed propionibacterium acnes as a result of microcirculatory disturbance caused by endothelial cell destruction by activated macrophages in the hepatic sinusoids. immunohistochemical hepatic expression of intercellular adhesion molecule-1 (icam-1) and lymphocyte function-associated antigen 1 alpha (lfa-1 alpha) and the effect of monoclonal antibodies against both adhesion molecules on liver necrosis p ... | 1996 | 8591859 |
| purification, characterization and anti-tumor activity of a new cytokine, histiocyte-secreted-factor (hsf). | purification of cytokines was carried out while monitoring their in vivo anti-tumor activity and in vitro cytotoxic activities. as a result, purified new cytokines were obtained from culture supernatant of a histiocytic cell line from rabbit serum. briefly, a new cytokine (hsf, histiocyte-secreted-factor) was purified from the culture of supernatant of the histiocytic cell line (tyh) which we established from the peripheral blood of a malignant-lymphoma patient. the purified samples exhibited su ... | 1996 | 8603813 |
| novel insight into molecular mechanism of endotoxin shock: biochemical analysis of lps receptor signaling in a cell-free system targeting nf-kappab and regulation of cytokine production/action through beta2 integrin in vivo. | lipopolysaccharide (lps), a constituent of gram-negative bacteria cell wall, plays an essential role in the pathogenesis of septic shock by generating endogenous mediators such as cytokines, nitrous oxide, superoxide anions, and lipid mediators. in vitro, lps induces the transcription of a set of genes involved in inflammatory reactions by activating several types of transcription factors, particularly nuclear factor-kappab (nf-kappab). an analysis of nf-kappab activation using a cell-free syste ... | 1996 | 8603986 |
| distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. | mycothiol [2-(n-acetylcysteinyl)amido-2-deoxy-alpha-d-glucopyranosyl- (1-->1)-myo-inositol] (msh) has recently been identified as a major thiol in a number of actinomycetes (s. sakuda, z.-y. zhou, and y. yamada, biosci. biotech. biochem. 58:1347-1348, 1994; h. s. c. spies and d. j. steenkamp, eur. j. biochem. 224:203-213, 1994; and g. l. newton, c. a. bewley, t. j. dwyer, r. horn, y. aharonowitz, g. cohen, j. davies, d. j. faulkner, and r. c. fahey, eur. j. biochem. 230:821-825, 1995). since thi ... | 1996 | 8606174 |
| alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. | alpha-melanocyte-stimulating hormone (msh) is a potent anti-inflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. we showed previously that alpha-msh inhibits nitric oxide (no) production in cultured macro-phages. to determine how alpha-msh acts in vivo, we induced acute hepatic inflammation by administering endotoxin (lps) to mice pretreated with corynebacterium parvum, alpha-msh prevented liver inflammation eve ... | 1996 | 8621792 |
| heat-killed corynebacterium parvum enhances endotoxin lung injury with increased tnf production in guinea pigs. | corynebacterium parvum (cp) is known to increase susceptibility to endotoxin, which is associated with increased production of tumor necrosis factor (tnf). we investigated the effect of cp-priming on the pathogenesis of acute lung injury caused by intratracheal escherichia coli endotoxin (lipopolysaccharide [lps]). guinea pigs were divided into four groups: (1) control (n=6), (2) cp-alone (n=6), (3) lps-alone (n=6) and (4) cp + lps (n=6). a cp dose of 4 mg/kg was injected intraperitoneally 7 d b ... | 1996 | 8630544 |
| efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from european clinical trials and experimental reports. | azelaic acid cream (20 percent) is a new topical treatment for acne with an additional therapeutic potential in rosacea and hyperpigmentation disorders. azelaic acid (aza; hooc-(ch2)7-cooh) is a naturally occurring compound that interferes with acne pathogenesis by virtue of its antikeratinizing, antibacterial, and anti-inflammatory properties. vehicle-controlled studies have verified that aza exercises a significant and clinically relevant effect on both non-inflammatory and inflammatory acne l ... | 1996 | 8654128 |
| an overview of acne and its treatment. | the pathophysiology of acne vulgaris results from the interplay of follicular hyperkeratinization, the presence of propionibacterium acnes bacteria in the follicular canal, and sebum production. several anti-acne agents are currently available that affect one or more of these pathogenic factors and are effective against one or more acne lesion types. the only currently available agent that is directly effective against comedones is tretinoin. agents effective against inflammatory lesions include ... | 1996 | 8654131 |
| all-trans retinoic acid suppresses liver injury induced by propionibacterium acnes and lipopolysaccharide in rats. | all-trans retinoic acid (atra) has been reported to exert major effects on the immune system, including monocytes/macrophages. the present study was designed to determine whether atra would modulate macrophage-associated liver injury induced by propionibacterium acnes and lipopolysaccharide (lps) in rats. all-trans retinoic acid administration alleviated the liver injury and reduced the incidence of death following hepatic failure. serum alanine aminotransferase (alt) levels 5 h after, and survi ... | 1997 | 9504902 |
| possible implication of sterile connecting device in contamination of pooled platelet concentrates. | considering the possibility that a pooled random donor platelet concentrate could become contaminated by welding with a sterile connecting device, we undertook a study to determine the influence of pooling on the contamination rate. as a control group, apheresis platelets were examined. bacteriological testing was done with a sensitive co2 detecting culture system, the bact/ alert. out of 1105 pooled platelet concentrates prepared by the buffy coat method, 15 (1.4%) were confirmed as contaminate ... | 1997 | 10175151 |
| [an analysis of the cause of misdiagnosis with ocular opportunistic infection]. | to evaluate the causes of misdiagnosis with ocular opportunistic infection. | 1997 | 10437001 |
| current options for the topical treatment of acne vulgaris. | the etiopathogenesis of acne vulgaris, a common disorder of youth and adolescence, includes four primary processes: hyperkeratinization (plugging) of the pilosebacous follicles, increased testosterone levels, bacterial colonization with propionibacterium acnes, and inflammation. no single agent has yet been developed that addresses all of these factors. combination regimens, therefore, which usually include an antibiotic and an agent to reduce follicular plugging, have become the mainstay of tre ... | 1997 | 9436851 |
| an outbreak of foal yersiniosis in poland: pathological and bacteriological examination. | in the springtime of 1995, 10 per cent of foals at a stud-farm died due to suppurative lesions. three dead foals were examined. the manifestations of watery diarrhoea and pneumonia were observed. a profuse growth of an enterotoxigenic strain of yersinia pseudotuberculosis was obtained from the internal organs of the foals. the foals with clinical symptoms of pneumonia and watery diarrhoea were immunized with propionibacterium acnes t. ii. all mares and their offspring from the stud were treated ... | 1997 | 9440204 |
| [diagnosis and treatment of neurosurgical shunt infections]. | 1997 | 9441323 | |
| fibronectin binding by propionibacterium acnes. | strains of propionibacterium acnes, isolated from different kinds of orthopaedic and biomaterial-associated infections and from skin flora were shown to express binding of soluble as well as immobilized fibronectin. among these 7 strains isolated from orthopaedic infections, 2 from breast prostheses, and 9 skin isolates, 2, 2, and 5 strains respectively bound immobilized fibronectin. the fibronectin binding was sensitive to protease and heat treatment, and was inhibited by a cell surface extract ... | 1997 | 9453395 |
| evaluation of root canal bacteria and their antimicrobial susceptibility in teeth with necrotic pulp. | this study aimed to evaluate the microbiota of necrotic pulp in teeth without carious lesions where the crown and root were intact and to test the sensitivity of this microbiota to antibiotics in order to improve treatment. the necrotic pulp was sampled from 26 single-rooted teeth in intact pulp chambers. a total of 84 strains were isolated. the number of species isolated per tooth varied from 2 to 8, with a strong component (81%) of anaerobic bacteria. the most commonly represented species were ... | 1997 | 9467386 |
| prevalence and identity of translocating bacteria in healthy dogs. | bacterial translocation is characterized by the passage of intestinally derived bacteria across the intestinal mucosa to local or regional tissues. this phenomenon is believed to be important in the pathogenesis of gram-negative bacteremia and septicemia; however, the pathway or route of translocation remains unclear. to define the route of translocation better, mesenteric lymph nodes from 50 apparently healthy dogs undergoing elective ovariohysterectomies were cultured aerobically and anaerobic ... | 1997 | 9470154 |
| [acute endocarditis of the native aortic valve caused by propionibacterium acnes]. | propionibacterium acnes is often considered to be a contaminant but it has also been found to be the principal pathogen in serious infections. p. acnes is a rare cause of infective endocarditis. it has been suggested that aortic root abscesses are caused by bacteria that are particularly virulent. the strongest risk factor for serious infections by this bacteria is the presence of foreign bodies. a case is presented in which endocarditis of a native aortic valve caused by p. acnes was associated ... | 1997 | 9470457 |
| investigation of the mechanism of action of 2% fusidic acid lotion in the treatment of acne vulgaris. | we describe the results of a single-centre, double-blind, vehicle-controlled, parallel group study on the quantitative effects of 2% fusidic acid lotion (fucidin lotion) in facial acne vulgaris. the trial was completed by 52 patients aged 15-25 years with mild to moderate acne who had been randomized to either fucidin lotion (n = 25) or its base (n = 27). primary outcome measures included colony counts of propionibacterium acnes and micrococcaceae and measurements of skin surface lipid free fatt ... | 1997 | 9536540 |
| enhancement of metastatic potential in a murine fibrosarcoma line by exposure to corynebacterium parvum-elicited macrophages; effect of eicosanoid biosynthesis inhibition. | 1997 | 9547624 | |
| kupffer cell activation with bcg. corynebacterium parvum or zymosan protects against acute liver injury induced by carbon tetrachloride in rats. | kupffer cells have been implicated in the pathogenesis of liver injury, but there is controversy about the effects of activation of these cells on the hepatotoxicity of chemicals and endotoxin. it has been shown that injection of corynebacterium parvum in rats induces macrophage activation that protects against toxic effects of carbon tetrachloride and acetaminophen, five days after injection, and this protection is due to inhibition of microsomal oxidizing enzymes and increased production of gl ... | 1997 | 9611293 |
| ph-dependent changes of nitric oxide, peroxynitrite, and reactive oxygen species in hepatocellular damage. | low arterial blood ph and sustained nitric oxide (no) production are critical parameters in inflammatory events such as sepsis, and appropriate treatment is still under debate. because the stability of nitrogen and oxygen intermediates is dependent on the surrounding ph, we investigated whether the relationship among no, peroxynitrite (onoo-), and reactive oxygen species production also depends on the ph value, particularly with respect to their effects on hepatocellular damage. our studies demo ... | 1997 | 9374710 |
| il-18 accounts for both tnf-alpha- and fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. | when lps is administered to heat-killed propionibacterium acnes-primed balb/c nude mice, they develop endotoxin-induced liver injury. as previously reported, this liver injury can be prevented by treatment with an ab against il-18, a novel cytokine with the ability to induce ifn-gamma production and up-regulate functional fas ligand (fasl) expression. to identify the pathologic role of il-18 in this liver injury, we investigated the hepatic cytokine network and fasl induction after lps challenge ... | 1997 | 9378984 |
| multicenter evaluation of the updated and extended api (rapid) coryne database 2.0. | in a multicenter study, 407 strains of coryneform bacteria were tested with the updated and extended api (rapid) coryne system with database 2.0 (biomérieux, la-balme-les-grottes, france) in order to evaluate the system's capability of identifying these bacteria. the design of the system was exactly the same as for the previous api (rapid) coryne strip with database 1.0, i.e., the 20 biochemical reactions covered were identical, but database 2.0 included both more taxa and additional differentia ... | 1997 | 9399506 |
| the relationship between moyamoya disease and bacterial infection. | to examine the relationship between moyamoya disease and bacterial infections, authors studied the serum of 85 cases of moyamoya disease and the influence of propionibacterium acnes (p. acnes) infection on intracranial arteries in rats. the serum levels of p. acnes antibody, igm, transferrin (tf), alpha 2-macroglobulin (alpha 2m) were significantly higher in moyamoya disease than in normal volunteers. moyamoya-like changes of the intracranial internal carotid arteries were histopathologically de ... | 1997 | 9409442 |
| [meropenem: microbiologic perspective]. | meropenem is a beta-lactamic carbapenem derived from thienamycin and is structurally characterized by the presence of a beta-methyl group in position c1 which confers stability to the molecule versus renal dehydropeptidase 1 (dhp-1), thereby making the coadministration of an enzyme inhibitor unnecessary. its esterochemical configuration of the lateral chain in c2 (dimethyl carbomoilpyrrolidenethium) increases the activity versus gram negative bacteria (enterobacteria and pseudomonas) and moreove ... | 1997 | 9410064 |
| [staphylococcal sepsis associated with platelet transfusion: report of a new case and review of the literature]. | bacterial contamination of blood components is an infrequent although potentially fatal event. bacterial contamination rate of platelet concentrates (pc) varies between 1/900 to 1/2,000 random donor units. however the risk of symptomatic bacteriemias is lower (between 1/2,000 to 1/12,000 random donor units). the organisms most commonly implicated in contaminated pc are gram-positive bacteria such as coagulase negative staphylococci, bacillus cereus or propionibacterium acnes, although gram-negat ... | 1997 | 9424743 |
| susceptibility of propionibacterium acnes, staphylococcus aureus and staphylococcus epidermidis to 10 kampo formulations. | we examined the in vitro sensitivities of three bacteria: propionibacterium acnes, and staphylococcus epidermidis, commonly detected in acne lesions, and staphylococcus aureus, a common cause of skin infections, to 10 kampo formulations (chinese herbal medicines; combinations of powdered extracts of crude drugs). both staphylococcus species showed similar sensitivities to all 10 formulations, with minimum inhibitory concentrations (mics) ranging from 25 to 400 mg/ml. p. acnes, however, was parti ... | 1997 | 9427165 |
| bacterial flora of stethoscopes' earpieces and otitis externa. | external otitis caused by staphylococcus aureus was observed in a nurse after extensive use of a stethoscope. the infection recurred and a similar organism was isolated from the stethoscope's earpiece. the infection did not recur after the earpiece was cleansed after each use. in a prospective study, the bacterial flora of 35 earpieces was evaluated. fifty-three isolates, 36 aerobic or facultative and 17 anaerobic, were recovered. the number of organisms per earpiece ranged from 14 to 204 (avera ... | 1997 | 9302906 |
| does oral isotretinoin prevent propionibacterium acnes resistance? | oral and topical antibiotics play a major role in acne therapy. physicians base treatment choices on personal perceptions of efficacy, cost-effectiveness or risk-benefit ratios and rarely take bacterial resistance into account. propionibacterium acnes isolates resistant to one or more anti-acne antibiotics have been reported in europe, the usa, japan and new zealand. therapeutic failure on some but not all antibiotic regimens is an increasing management problem. in leeds, uk, resistant strains a ... | 1997 | 9310739 |
| spread of antibiotic-resistant bacteria from acne patients to personal contacts--a problem beyond the skin? | 1997 | 9329508 | |
| comparison of serum antibiotic levels in acne patients receiving the standard or a modified release formulation of minocycline hydrochloride. | serum levels of minocycline hydrochloride were determined by bioassay in a total of 223 acne patients (123 male, 100 female) receiving either the recommended dose (100mg/day) or a high dose (200mg/day) of the standard preparation (101 patients) of a modified release formulation (132 patients). sera were collected within 6 h of the morning dose 7-10 days after the start of treatment. mean minocycline serum levels were consistently higher in females than in males, irrespective of dose or formulati ... | 1997 | 9330069 |
| effects of exercise on the macrophage mhc ii response to inflammation. | the purpose of this investigation was to determine the effects of different doses of exercise on the ability of propionibacterium acnes (p. acnes) to induce major histocompatibility complex (mhc) ii antigen expression on macrophages (m phi's). pathogen-free male balb/c mice were exercised on a treadmill moderately (mod, 15-17 m/min, 5% grade, 30 min/day) or exhaustively (exh, 15-40m/min, 5% grade, 2-4hr/day) for a period of 7 days during p. acnes-induced inflammation. a control group (con) consi ... | 1997 | 9351697 |
| delayed infection after elective spinal instrumentation and fusion. a retrospective analysis of eight cases. | a retrospective analysis of eight cases of delayed spinal infection after elective posterior or combined anterior and posterior spinal instrumentation and fusion. | 1997 | 9355228 |
| lethal effect of recombinant human fas ligand in mice pretreated with propionibacterium acnes. | fas ligand (fasl) is a type ii membrane protein. binding of fasl to its receptor, fas, induces apoptosis. matrix metalloproteinase cleaves the membrane-bound human fasl to yield the active soluble form. here, we have produced a large amount of human soluble rfasl using the yeast, pichia pastoris. the purified rfasl was found to be glycosylated and to exist as a trimer. the rfasl was effective in inducing apoptosis in a fas-expressing t cell or a fibroblast cell line. the id50 of rfasl for mouse ... | 1997 | 9036978 |
| porphyrin sensitization and intracellular calcium changes in the prokaryote propionibacterium acnes. | photosensitization induces intracellular free calcium changes ([ca2+]i) in some eukaryotic cell systems which either contribute to or protect against cell inactivation. we have investigated whether or not similar changes can be induced in prokaryotes. the skin bacterium propionibacterium acnes was sensitized using protoporphyrin ix (pp ix) or 5-aminolevulinic acid (ala). exogenous ala resulted in either a preferential accumulation of protoporphyrin (ala-pp) or of coproporphyrin and/or uroporphyr ... | 1997 | 9432522 |
| propionebacterium acnes in cultures from ventriculo-peritoneal shunts: infection or contamination? | we have examined the accuracy of our present csf sampling technique in 14 referred patients with suspect shunt dysfunction. the study was performed comparing culture results from shunt reservoir punctures and sham samples from skin tissue fluid close to the reservoirs. propionebacterium acnes (p acnes) was found in five of fifteen cultures from reservoir punctures and in five of fifteen sham procedures. positive cultures correlated in two cases. thirteen of the fourteen patients included in the ... | 1997 | 9059709 |
| enhancement of lung-colonizing potential of murine tumor cell lines co-cultivated with activated macrophages. | in order to explore the influence of activated macrophages on tumor cells, we cultured a series of weakly metastatic clones isolated from the murine t3 fibrosarcoma line (t3 clones) and the b16-f10 melanoma cells on feeder layers of c. parvum- or thioglycollate-elicited macrophages, or 'resident' (unstimulated) macrophages. co-cultivation with c. parvum-elicited macrophages, but not with resident macrophages, induced an increase of the lung-colonizing potential of t3 clones and b16-f10 cells. an ... | 1997 | 9062385 |
| preoperative disinfection of the conjunctival sac in cataract surgery. | conjunctival cultures were obtained from 488 patients undergoing cataract extraction. bacterial isolation rates from the lids and conjunctiva were 84.6 and 36.7, respectively. propionibacterium acnes was the only anaerobic organism identified. a significantly lower incidence of p. acnes was observed in the eyes after preoperative conjunctival irrigation using povidone-iodine solution (9%) compared with those using benzetonium chloride solution (30%). topical use of ofloxacin and cefmenoxime for ... | 1997 | 9065940 |
| immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around propionibacterium acnes-induced granulomas in the rat liver. | stellate cells embrace the hepatic sinusoids as pericytes. to demonstrate their activation in juxta-sinusoidal location, we induced hepatic granulomatous inflammation, which did not accompany liver injury nor fibrosis, by administrating a low dose (10 mg/kg b.w.) of heat-killed propionibacterium acnes into rats. macrophages and lymphocytes migrated out of the sinusoid and made compact granulomas in the space of disse. stellate cells which faced on the granulomas were closely attached to the sinu ... | 1997 | 9066151 |
| [propionibacterium acnes empyema]. | 1997 | 9091110 | |
| essential roles of the fas ligand in the development of hepatitis. | the fas ligand (fasl) is expressed in activated t cells and induces apoptosis in fas-bearing cells. a cytotoxic t lymphocyte (ctl) clone specific for hepatitis b surface antigen (hbsag) causes an acute liver disease in hbsag transgenic mice. here we observed that the ctl clone killed hepatocytes expressing hbsag in a fas-dependent manner. administration of the soluble form of fas into hbsag transgenic mice prevented the ctl-induced liver disease. in the second model, mice were primed with propio ... | 1997 | 9095174 |
| therapy for acne vulgaris. | 1997 | 9099661 | |
| cloning and sequencing of the hyaluronate lyase gene from propionibacterium acnes. | the hyaluronate lyase (hyaluronidase) gene from propionibacterium acnes was cloned and sequenced. the gene was isolated on an ecori-generated 3-kb piece of dna. expression was less in escherichia coli than in p. acnes; in e. coli, active enzyme was only cell associated and not secreted. the gene is 2256-pb long and codes for a protein of 82 kda. amino terminal sequencing of the protein of the partially purified gene indicated the presence of a 32-amino-acid leader sequence. the leader sequence s ... | 1997 | 9115089 |
| bacterial lipopolysaccharide rapidly inhibits expression of c-c chemokine receptors in human monocytes. | the present study was designed to investigate the effect of bacterial lipopolysaccharide (lps) on c-c chemokine receptors (ccr) expressed in human mononuclear phagocytes. lps caused a rapid and drastic reduction of ccr2 mrna levels, which binds mcp-1 and -3. ccr1 and ccr5 mrnas were also reduced, though to a lesser extent, whereas cxcr2 was unaffected. the rate of nuclear transcription of ccr2 was not affected by lps, whereas the mrna half life was reduced from 1.5 h to 45 min. as expected, lps- ... | 1997 | 9120403 |
| a retrospective analysis of microbial contaminants in outdated random-donor platelets from multiple sites. | platelet components contaminated with bacteria are an important source of transfusion-associated bacterial sepsis. estimates of contamination rates vary widely (0-10%) and are highly controversial. the present study, designed with stringent testing regimens, retrospectively determined the prevalence of microbial contaminants in platelets from four collection regions. | 1997 | 9122897 |
| tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. | accumulating evidence implicates tumor necrosis factor (tnf) and fas systems in liver injury, although the interaction between these two systems remains to be investigated. in this study, we examined propionibacterium acnes-primed tnf receptor p55-deficient (tnfrp55-/-) or fas-deficient mrl/mpj lpr/lpr mice challenged with lipopolysaccharide (lps). priming with p. acnes caused mononuclear cell infiltration into the hepatic lobules and granuloma formation in the livers of tnfrp55 wild-type mice. ... | 1997 | 9125577 |
| preventive effect of cyclosporin a on experimentally induced acute liver injury in rats. | we examined the effect of cyclosporin a (csa) on the pathogenesis of acute experimental liver injury in rats induced by injection of heat-killed propionibacterium acnes (p. acnes) and subsequent injection of lipopolysaccharide (lps). pretreatment with csa significantly reduced serum alanine aminotransferase (alt), serum tumor necrosis factor-alpha (tnf-alpha) production, without changing the tnf-alpha mrna level in the liver, and plasma interferon-gamma (ifn-gamma), following lps injection in th ... | 1997 | 9138282 |
| chronic propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. | although the pathogenesis in most cases of intermediate uveitis is unknown, a small minority of cases is associated with a variety of specific inflammatory etiologies: sarcoidosis; multiple sclerosis; lyme disease; syphilis; ocular lymphoma; and as a rare manifestation of behçet's disease and aids. a 61-year-old woman developed pars planitis after cataract surgery. a vitrectomy was performed after ten months when a white capsular plaque and an hypopyon developed. propionibacterium acnes was isol ... | 1997 | 9145695 |
| [propionibacterium acnes infection in patients with csf shunts]. | propionibacterium acnes is a common inhabitant of human skin rarely associated with clinical disease. however it has been recognized as a cause of shunt and postneurosurgical infections. from january 1992 to june 1995, 5,947 cerebrospinal fluid (csf) samples were cultured in our laboratory. we carried out a clinical-epidemiological study in patients where p. acnes was isolated from csf. | 1997 | 9147504 |
| exocellular phospholipase c activity from a propionibacterium acnes strain isolated from a periodontal pocket. | the culture supernatant of a strain of propionibacterium acnes was investigated for its phospholipase (pl) activity. the microorganism was isolated from a periodontal pocket of a patient with periodontal disease. supernatants from cultures of this microorganism were used as a source to obtain enzymes. proteins from the supernatants were concentrated, and their enzymatic activity was partially purified through molecular sieving. the procedure yielded two peaks of activity. this activity was shown ... | 1997 | 9150042 |
| bacteraemia caused by periodontal probing. | bacteraemia of oral origin may result in infective endocarditis in susceptible individuals. the aim of this pilot study was to investigate the occurrence of bacteraemia due to periodontal probing. thirty patients (15 male, 15 female; mean age 42.7 years) with untreated periodontitis were investigated. all were free of significant medical disorders and none had taken antibiotics in the previous month. prior to and immediately following periodontal probing, 20 ml of venous blood were obtained from ... | 1997 | 9153833 |
| adjuvant therapy for melanoma. | the search for effective adjuvant therapy for melanoma has resulted in the testing of a remarkably broad spectrum of therapeutic agents. until recently, there was little evidence to suggest a benefit for any adjuvant therapy. the demonstration of activity for adjuvant high-dose interferon alfa in a cooperative group trial resulted in food and drug administration approval and has dramatically changed the melanoma landscape. this article reviews all the randomized adjuvant trials conducted to date ... | 1997 | 9161800 |
| propionibacterium acnes, a resident of lipid-rich human skin, produces a 33 kda extracellular lipase encoded by geha. | five independent clones of the propionibacterium acnes p-37 lipase gene (geha) were obtained in escherichia coli, and the gene was localized to a 2.75 kb xhol fragment by subcloning. the five clones were shown to contain the same gene by southern blotting with a dig-labelled probe to geha. the nucleotide sequence of geha was determined, and shown to contain a single orf of 1017 kb, encoding a protein of 339 amino acids. the predicted molecular mass was 36 kda. a 33 kda (page) radiolabelled polyp ... | 1997 | 9168624 |
| [pharma clinics. drug of the month. benzamycin, an up-date on topical treatment of acne]. | 1997 | 9173479 | |
| experimental hepatitis in neonatally thymectomized mice: transfer of disease and the role of t cells. | using neonatally a/j thymectomized mice, we have produced chronic hepatitis by administration of sublethal doses of propionibacterium acnes and lipopolysaccharide (lps). our goal in this unique model was to evaluate the effector cell population required to generate chronic hepatitis by transferring spleen cells or splenic subpopulations derived from donor thymectomized mice with chronic hepatitis into congenic recipient nonimmunized thymectomized or sham-thymectomized animals. several key observ ... | 1997 | 9175920 |
| ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. | 1. ro 32-3555 (3(r)-(cyclopentylmethyl)-2(r)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (ki values of 3.0, 4.4 and 3.4 nm, respectively). the compound is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases a and b (ki values of 527, 154 and 59 nm, respectively). 2. ro 32-3555 inhibited interleukin-1 alpha (il-1 a ... | 1997 | 9179398 |