Publications

listeria monocytogenes cerebritis, bacteremia, and cutaneous lesions complicating hairy cell leukemia.	hairy cell leukemia is a lymphoreticular malignancy characterized by a chronic course and multiple defects in host defense mechanisms. infections are the major cause of morbidity and mortality in this malignancy. opportunistic infections due to pathogens normally controlled by cell-mediated immune mechanisms have been increasingly described but have not included listerial infections. this report describes a case of disseminated listeria monocytogenes infection including the uncommon manifestatio ...	1986	3799637
abilities of human oligodendroglial cells and mouse schwann cells to phagocytose mycobacterium leprae and other mycobacteria.	human oligodendroglial kg-1-c cells derived from human cerebral mixed glioma and mouse schwann cells derived from dorsal root ganglion were studied with respect to their abilities to phagocytose various mycobacteria, especially mycobacterium leprae, and other microorganisms. kg-1-c cells phagocytosed m. leprae at a markedly higher rate than balb/3t3, bhk 21, hela s3, mks-a tu-7, xc, tsv-5, n-18, and schwann cells but at a lower rate than peritoneal macrophages. schwann cells also exhibited subst ...	1986	3510165
effects of suramin on the in vivo antimicrobial resistance against listeria monocytogenes and mycobacterium bovis (bcg) in mice.	following one intraperitoneal injection of suramin (400 mg/kg) in mice, biphasic alterations of the resistance to listeria monocytogenes were observed, depending on the timing of the drug administration in relation to the intravenous challenge. treatment with suramin, concomitantly or 1 day before, enhanced markedly the bacterial growth in spleen and liver, detected as early as 3 to 6 h after the challenge, the maximum being observed at 48 h in the liver. in contrast, an increased resistance was ...	1986	3514011
treatment of listeria monocytogenes infection with trimethoprim-sulfamethoxazole: case report and review of the literature.	a 55-year-old female recipient of an orthotopic liver transplant, who was receiving azathioprine, prednisone and cyclosporin, developed bacteremia due to listeria monocytogenes. because of a penicillin allergy, the patient was treated primarily with trimethoprim-sulfamethoxazole, to which she responded well. the prior literature on use of trimethoprim-sulfamethoxazole in listeria infections is reviewed, and future recommendations are considered. on the basis of the experience described in this c ...	1986	3523699
macrophage suppression by a low-molecular-weight fraction of murine spleen cell culture supernatant.	macrophage suppression has been reported to be mediated by a component of murine serum. the present investigation involves in vitro production of this macrophage modulator (suppressor) by concanavalin a-stimulated murine spleen cells. spleen cell culture supernatant containing this suppressor, which has been called macrophage suppressor factor (msf), caused a significant decrease in in vitro phagocytosis of listeria monocytogenes by resident murine peritoneal macrophages. the molecular weight of ...	1986	3527448
increased phagocytic activity in mice treated by a mouse granuloma protein.	intravenous injection of a protein extracted from a talc-induced granuloma (mgp) enhanced the blood clearance of a highly virulent strain of salmonella typhimurium. this protein was able to enhance mouse resistance to systemic infection with listeria monocytogenes when injected one or two days prior to infection. furthermore, since mgp-treated athymic mice were also protected against listeria infection, mature t cells were most likely not involved in this enhanced resistance. these findings sugg ...	1986	3530114
immunotoxicity studies in mice exposed to methyl isocyanate.	the effects of methyl isocyanate (mic) on systemic immunity were evaluated in female b6c3f1 mice exposed via inhalation to 0, 1, or 3 ppm for 6 hr per day on four consecutive days. humoral immunity, measured as the antibody response to sheep erythrocytes, and natural killer cell activity were not affected by mic. furthermore, resistance to the infectious agents listeria monocytogenes, mouse malaria parasite, and influenza virus, or to b16f10 transplantable tumor cells, was not compromised by mic ...	1986	3532429
complement split product c5a mediates the lipopolysaccharide-induced mobilization of cfu-s and haemopoietic progenitor cells, but not the mobilization induced by proteolytic enzymes.	intravenous (i.v.) injection of mice with lipopolysaccharide (lps), and the proteolytic enzymes trypsin and proteinase, mobilizes pluripotent haemopoietic stem cells (cfu-s) as well as granulocyte-macrophage progenitor cells (gm-cfu) and the early progenitors of the erythroid lineage (e-bfu) from the haemopoietic tissues into the peripheral blood. we investigated the involvement of the complement (c) system in this process. it appeared that the early mobilization induced by lps and other activat ...	1986	3533267
bacterial meningitis in infants two to six weeks old.	we reviewed our experience with bacterial meningitis in older neonates (2 to 6 weeks of age) during a five-year period. seventeen patients with bacterial meningitis were diagnosed and treated. bacteria recovered from the cerebral spinal fluid (csf) included pneumococci (29%), e. coli and meningococci (23% each), group b streptococci (12%), enterobacter and h. influenzae (6% each). there were no cases of listeria monocytogenes. the mean duration of symptoms before admission was 3.1 days. the mort ...	1986	3539885
functions of mononuclear phagocytes in mice exposed to diethylstilbestrol: a model of aberrant macrophage development.	administration of the synthetic estrogen diethylstilbestrol (des) lowers the systemic resistance of mice to challenge with either tumor cells or the facultative intracellular parasite listeria monocytogenes. to assess the potential role of impaired mononuclear phagocyte system (mps) function in this depression of host resistance, we addressed the question of systemic perturbations of the mps induced by administration of des. a panel of objective quantitative markers which have been previously sh ...	1986	3802203
transfer of enhanced resistance against listeria monocytogenes induced with ribosomal rna and the adjuvant dimethyldioctadecylammonium bromide.	in this study we investigated the mechanism of enhanced resistance against listeria monocytogenes induced with listeria ribosomal rna and the adjuvant dimethyldioctadecylammonium bromide (dda). mice immunized with dda alone (which were not protected against listeria-infection) were used as negative controls. mice immunized with rna plus dda were found to have an increased capacity to mobilize polymorphonuclear leukocytes (pmns) and macrophages to the inflamed peritoneal cavity compared to mice i ...	1986	3804382
bactericidal activity and killing rate of serum in volunteers receiving ciprofloxacin alone or in combination with vancomycin.	ten healthy volunteers received the following regimen on different days: vancomycin, 500 mg intravenously; ciprofloxacin, 200 mg intravenously; vancomycin plus ciprofloxacin. concentrations in serum measured microbiologically at the end of infusion and 1 and 6 h after the end of infusion were, respectively (mean [standard deviation] in milligrams per liter): 32.3 (5.5), 14.2 (2.6), and 4 (0.9) for vancomycin and 3.12 (0.86), 0.78 (0.18), and 0.19 (0.05) for ciprofloxacin. vancomycin concentratio ...	1986	3813515
dissociation between enhanced resistance and delayed hypersensitivity induced with subcellular preparations from listeria monocytogenes and the adjuvant dimethyl-dioctadecyl-ammonium bromide.	in this study we investigated the relation between enhanced resistance and delayed hypersensitivity (dh) induced with subcellular preparations from listeria monocytogenes and the adjuvant dimethyldioctadecylammonium bromide (dda). ribosomal rna as well as cell envelope fragments (fraction i) protected mice against lethal listeria infection. however, only fraction i induced dh against killed listeria. for the induction of protection with fraction i or rna as well as for the induction of dh with f ...	1986	2425734
localization of antigen-specific lymphocytes following lymph node challenge.	the effect of subcutaneous injections of brucella abortus strain 19 antigen on the specific localization of autologous lymphocytes in the regional nodes of calves was analysed by fluorescent labelling and flow cytometry. both in vitro and in vivo fitc labelling of lymphocytes indicated the preferential migration of lymphocytes from a previously challenged lymph node to a recently challenged lymph node. however, lymphocytes from a lymph node challenged with b. abortus failed to localize preferent ...	1986	2426183
[effect of lipid fractions isolated from listeria monocytogenes on rna and protein biosynthesis in the liver and spleen of rats].		1986	2431599
induction of an atypical interferon by bacteroides fragilis and escherichia coli in experimental infections and in leukocyte cultures.	previous reports have shown that bacteroides fragilis may enhance the pathogenicity of coinfecting enterobacteriaceae by interfering with the host's immune response. with the present study, we have investigated the possible role of interferons (ifn) in mediating these effects. mice injected with b. fragilis developed moderate serum levels of ifn that appeared just prior to alterations of the animals' immunity described earlier. the ifn was neutralized by treatment with anti-ifn-alpha/beta-antibo ...	1986	2434431
septicemia due to listeria monocytogenes in a newborn foal.		1987	17422889
mechanism of recovery from acute virus infection. iv. questionable role of mononuclear phagocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.	after intravenous infection of mice with 10(3) infectious units (iu) the we strain lymphocytic choriomeningitis (lcm) virus multiplied in the spleens (as in all other major organs), reaching more than 10(8) iu/g of tissue on days 4 to 5. subsequently, the virus was quickly eliminated, being below detectability usually by day 10. during the time of virus clearance, the mononuclear phagocytes (mnp) of the spleen were activated as revealed by suppression of growth of listeria monocytogenes and incr ...	1987	2435795
antigen-specific augmentation factor involved in murine delayed-type footpad reaction. ii. augmentation of delayed-type footpad reaction and acquired resistance to listeria monocytogenes by transfer of listeria-immune serum.	we previously found an antigen-specific factor capable of augmenting delayed-type hypersensitivity (dth) in the culture supernatant of the mixture of immune spleen cells and erythrocyte antigen, or in the serum of mice immunized with heterologous erythrocytes and exhibiting delayed-type footpad reaction. to elucidate whether this kind of factor (dth-augmentation factor; daf) participates in the establishment of dth to various kinds of antigen besides erythrocyte antigen, we chose a bacterial ant ...	1987	2443824
induction by killed listeria monocytogenes of effector t cells mediating delayed-type hypersensitivity but not protection in mice.	using a local passive transfer system, we found that effector t cells mediating delayed-type hypersensitivity (dth) but not acquired cellular resistance (acr) to listeria monocytogenes (strain egd) were generated in mice immunized with killed listeria, although immunized mice did not express dth or acr. when non-adherent cells of peritoneal, lymph node, or spleen cells from mice immunized with killed listeria were transferred into the footpad of naive recipient mice along with eliciting antigen, ...	1987	2445666
depression of murine hepatic mixed function oxidase during infection with listeria monocytogenes.	the level of cytochrome p-450 and the oxidation of aminopyrine and benzo(a)pyrene hydroxylase were depressed in hepatic microsomes prepared from mice infected with the gram positive bacteria listeria monocytogenes. maximum depression of mixed function oxidase occurred on the 2nd day of infection. this loss in drug biotransformation capacity in the liver was correlated directly with the number of organisms found in that organ. the ability of mice to metabolize drugs in vivo also was impaired duri ...	1987	2447264
effect of anti-inflammatory drugs on the production of tumour necrosis factor and lipopolysaccharide induced-mortality in mice.	mice injected with viable listeria monocytogenes or powdered corynebacterium parvum and challenged with endotoxin released tumour necrosis factor (tnf) into the blood. however, the rate of mortality from endotoxin shock was high. administration of the non-steroidal anti-inflammatory drugs acetylsalicylate, indomethacin and phenylbutazone protected the animals against the lethal effect of endotoxin without affecting the ability of animals to produce tnf. the significance of these observations are ...	1987	3828981
an in-vitro comparison of the intraphagocytic bioactivity of erythromycin and roxithromycin.	the binding to human polymorphonuclear leucocytes and the intracellular bioactivity of the macrolide antibiotics erythromycin and roxithromycin on legionella micdadei, listeria monocytogenes and staphylococcus aureus were investigated in vitro by the combination of a fluorochrome microassay and a radioassay. polymorphs with intact or absent membrane-associated oxidative metabolism were used to investigate the interactions which may occur between the intrinsic oxygen-dependent antimicrobial syste ...	1987	3429387
[clinical and therapeutic observations on meningitis caused by listeria monocytogenes].		1987	3431206
remote effects of inflammation on non-specific immunity.	following inflammation induced in mice with non-biodegradable, non-diffusible, and non-antigenic substances, host resistance is increased against bacteria, parasites and malignant cells injected at a distance from the inflammatory focus. this resistance is also increased in germ-free and nude mice. the increased resistance is correlated with (1) an increased leukopoiesis induced, at least in part, by a protein (mw = 40 kda, pi = 5.2) which, in vitro, is able to induce the differentiation of bone ...	1987	3443469
ci-934, a new difluoroquinolone: in vitro antibacterial activity and proposed disk diffusion test interpretive criteria.	the susceptibility of 7,763 clinical isolates at four medical centers to ci-934 and three comparative quinolones was tested. ci-934 was the most active compound against gram-positive isolates, such as staphylococci (mic 90 = 0.25 microgram/ml), and enterococci (mic 90 = 0.5 microgram/ml). ci-934 was the least active of these drugs against pseudomonas spp. (mic 90 = greater than 8.0 micrograms/ml). against all other organisms ci-934 was very effective, being most comparable with enoxacin. with a ...	1987	3471371
in vitro activity of ci-934 compared with ciprofloxacin, enoxacin, norfloxacin, and vancomycin.	the in vitro activity of the quinolone ci-934 was compared with ciprofloxacin, norfloxacin, enoxacin, and vancomycin against 607 gram-positive and -negative isolates. ci-934 inhibited 90% of the enterobacteriaceae, aeromonas hydrophila, and acinetobacter spp. at 1 microgram/ml. decreased activity was observed against pseudomonas aeruginosa. pseudomonas maltophilia, and other pseudomonas spp. with ci-934 mic90 greater than or equal to 8 micrograms/ml. ci-934 activity against gram-positive organis ...	1987	3472704
comparative in vitro activities of pefloxacin, ofloxacin, enoxacin and ciprofloxacin against 256 clinical isolates.	the antibacterial activity of four new fluoroquinolone carboxylic acids, pefloxacin, ofloxacin, enoxacin and ciprofloxacin, against 256 clinical isolates was investigated by means of an agar dilution method. generally, all quinolones tested had a high activity against gram-negative bacteria. more than 90% of enterobacteriaceae strains were inhibited by a quinolone concentration of 0.4 microgram/ml. also strains usually resistant to conventional beta-lactam antibiotics, and sometimes to third-gen ...	1987	3473910
[listeria monocytogenes infection in children].	listeria monocytogenes infection is relatively unusual in children. two cases are reported which illustrate that meningitis and septicemia are the most frequent manifestations at this age. prognosis is especially bad in immunodeficient patients.	1987	3476024
in vitro activity of ciprofloxacin against gram-positive bacteria. an overview.	a review of european data published before july 1986 and data from the authors' laboratory showed very similar activity of ciprofloxacin against gram-positive bacteria in all studies. mean minimal inhibitory concentrations against 50 percent (mic50) and 90 percent (mic90) of staphylococcal strains were 0.32 and 0.59 mg/liter, respectively. the drug was equally active against staphylococcal strains resistant and susceptible to methicillin and/or gentamicin. the range of mic50 and mic90 values for ...	1987	3555058
differential growth of legionella pneumophila in guinea pig versus mouse macrophage cultures.	legionella pneumophila is a facultative intracellular bacterium which replicated well in inbred guinea pig strain 2 peritoneal macrophages at a low infectivity ratio. in contrast, the growth of this organism was markedly restricted in mouse (bdf1) peritoneal macrophages, even at a relatively high infectivity ratio. the initial uptake of l. pneumophila organisms by macrophages was similar in both animal species, and both groups of macrophages supported the growth of listeria monocytogenes. treatm ...	1987	3570468
lack of synergism of ampicillin and gentamicin in experimental listeriosis.	strain slcc 4013 of listeria monocytogenes is susceptible in vitro to ampicillin (mic 0.5 mg/l) as well as to gentamicin (mic 0.5 mg/l). whereas treatment of mice infected with this virulent strain with 0.5 mg ampicillin twice a day resulted in a marked decrease in bacterial counts per spleen, the administration of 2 mg gentamicin twice a day hardly reduced bacterial multiplication. the combination of both drugs was not much more effective than ampicillin alone. thus, a synergistic effect of bot ...	1987	3570481
transient immunologic defect in a case of listeria rhombencephalitis.	we report a case of listeria rhombencephalitis in a previously healthy 60-year-old man. listeria rhombencephalitis is a rare but well-defined clinical syndrome of lower brain-stem involvement caused by listeria monocytogenes. contrary to other listerioses, rhombencephalitis has been mainly observed in patients without predisposing conditions. in our case, however, findings of a detailed immunologic study, performed three months and one year, respectively, after clinical onset of listeria rhomben ...	1987	3579687
[septicemia caused by listeria monocytogenes in the adult].		1987	3586746
listeria monocytogenes and the acquired immunodeficiency syndrome.		1987	3800521
immunomodulation of gvh reaction in mice by listeria monocytogenes.	in the first part of experiments the gvhr activity of the spleen cell suspensions from normal parental donors (balb/c) or infected with listeria monocytogenes was compared. gvhr was examined in (balb/c x akr) f1 mice. full suspensions from these donors or depleted of adherent cells or with addition of macrophages were studied. it has been proved that adherent cells population plays a significant role in the gvhr development. the addition of syngeneic macrophages from f1 hybrids results in a grea ...	1987	3128245
[congenital listeriosis].		1987	3131937
in vitro sensitivity of 65 listeria monocytogenes isolates to new and old antibiotics.		1987	3151351
vaccination with a listeria strain of reduced virulence against experimental listeria abortion in goats.	a live listeria monocytogenes strain of reduced virulence, strain aer, obtained by three successive mutations in regard to streptomycin and erythromycin, was used as vaccine on goats in two successive experiments. animals were vaccinated either once or twice by subcutaneous route with doses varying from 6 x 10(8) to 1.5 x 10(10) cfu. no side effect was observed, except in one goat, vaccinated as pregnant, that aborted and from which the vaccinal strain was reisolated. the goats were challenged b ...	1987	3132075
particulate antigens may be reprocessed after initial phagocytosis for presentation to t cells in vivo.	macrophages were pulsed with listeria monocytogenes antigens by intraperitoneal injection prior to harvesting and thoroughly washing the cells. the pulsed macrophages were injected into the feet of listeria-immune or naive mice to elicit a delayed hypersensitivity reaction. where soluble listeria antigen was used, presentation by donor macrophages to host t cells required identity within the i region of the h-2 complex. however, presentation of alcohol-killed listeria organisms or of a living, t ...	1987	3129365
purified human and recombinant murine interleukin-1 alpha induced accumulation of inflammatory peritoneal neutrophils and mononuclear phagocytes: possible contributions to antibacterial resistance.	interleukin-1 (il-1) mediates a number of proinflammatory biological responses that are thought to contribute to antibacterial resistance. in the present study we examined the ability of il-1 to recruit inflammatory neutrophils and mononuclear phagocytes in vivo; a function that has been reported to be closely related to antibacterial resistance. intraperitoneal injection of small amounts (1-10 laf units) of purified human or recombinant murine il-1 alpha (ril-alpha) resulted in an increased inf ...	1987	3143888
modulation of cell-mediated resistance to listeriosis in mice given t-2 toxin.	the modulating effect of preinoculation and postinoculation treatment with a single oral 4.0 mg/kg dosage of t-2 toxin on cell-mediated resistance was studied in mice inoculated with listeria monocytogenes. toxin treatment caused significant decreases in thymus and spleen weights, bone marrow cellularity, and in the total number of circulating leukocytes, lymphocytes, and neutrophils. enhancement or suppression of resistance to listeriosis was dependent on the time of toxin administration relati ...	1987	3603564
listeria monocytogenes infection and hairy cell leukemia.		1987	3605174
corneal ulcer due to listeria monocytogenes.	we present a patient with a corneal ulcer due to listeria monocytogenes, which has not previously been considered to be a feature of human listeriosis. the ulcer responded to topical and subconjunctival gentamicin and cephaloridine. subsequent management was complicated by the development of a fibrinous pupillary membrane leading to pupillary block requiring iridotomy and later vitrectomy with trabeculectomy. listeria monocytogenes may be confused with diphtheroid contaminants seen in corneal ul ...	1987	3608514
[recent trend of childhood bacterial meningitis in japan (1979-1984). part 4. a classification of prognosis and antibiotic treatment based on causative agents].	nine hundred seventy cases of childhood bacterial meningitis treated at 107 institutions in japan from 1979 through 1984 were studied using questionnaire. the number of cases that underwent antimicrobial monotherapy remained nearly constant during the study period, but cases of therapies with beta-lactam combined with aminoglycosides (ags) decreased in number and a gradual increase in the use of beta-lactam combined with non-ags antibiotics including beta-lactam (non ags) was observed. a trend s ...	1987	3613093
comparative in vitro activity of ci934, a new fluoroquinolone, alone and in combination with coumermycin, against gram-positive bacteria.	the in vitro activity of cl934, a new quinolone antimicrobial agent, was studied against 314 strains of gram-positive bacteria representing 6 genera: staphylococcus aureus, streptococcus faecalis, s. agalactiae, s. pyogenes, s. pneumoniae, s. milleri, viridans streptococci, listeria monocytogenes, corynebacterium jk, mycobacterium fortuitum and bacillus spp.; and compared with that of enoxacin, ciprofloxacin, penicillin g, ampicillin, coumermycin, oxacillin, vancomycin, teicoplanin, rifampin, ri ...	1987	3622241
in vitro evaluation of the new paulomycin antibiotic paldimycin.	the comparative in vitro activity of paldimycin, a new antibiotic, was evaluated against 215 gram-positive bacteria. activity of the compound was greater in nutrient agar of ph 6.8 than in mueller-hinton agar. all strains of staphylococci, streptococci, enterococci and listeria monocytogenes were inhibited at concentrations less than or equal to 2 micrograms/ml. activity of the new drug was generally comparable to that of vancomycin.	1987	3622497
mri of listeria rhombencephalitis.	a case of listeria rhombencephalitis in a patient, who was evaluated by mri, is reported. mri showed areas of high signal intensity on t2-weighted images in the rhombencephalon and confirmed the clinical diagnosis of a brainstem affection by listeria monocytogenes.	1987	3627425
endotoxin shock and tumour necrosis factor release in mannoheptulose-treated mice.	administration of mannoheptulose partially protected mice infected with listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. the ability of these animals to produce tumour necrosis factor was however unaffected. mannoheptulose was observed to reverse the hypoglycaemic effect of endotoxin, possibly through inhibition of insulin secretion. the therapeutic significance of these observations is discussed.	1987	3664450
clinical manifestations of epidemic neonatal listeriosis.	we report the broad spectrum of clinical manifestations in 23 infants with positive cultures for listeria monocytogenes who were treated in our hospital during a recent epidemic. the majority of infants (70%) were preterm and none was small for gestational age. thirteen (56%) had respiratory distress at birth with evidence of congenital pneumonia. four of the 5 deaths occurred among these infants. four infants considered healthy after resuscitation developed fever and lethargy within 36 hours af ...	1987	3670948
[listeria monocytogenes spontaneous peritonitis of the cirrhotic patient].		1987	3671852
arterial occlusion due to listeria meningoencephalitis in an immunocompromised boy.	sequential cat scan studies of the brain were performed in a 7-year-old boy with listeria monocytogenes serotype 1 meningoencephalitis. the infection occurred while he was receiving maintenance chemotherapy for t-cell non-hodgkin lymphoma. a lesion in the right hemisphere during the infection resulted in an excessive enlargement of the right ventricle 10 months later, most probably caused by arterial occlusion.	1987	3672054
listeriosis in diacetoxyscirpenol-treated mice.	mice were treated with the trichothecene mycotoxin diacetoxyscirpenol (das) and subsequently were inoculated intraperitoneally with listeria monocytogenes. the effect of the mycotoxin on the course of the infection was monitored by observing the resultant mortality and the bacterial content of the spleens from inoculated mice. mice given 3 mg of das/kg of body weight, po, at days -2 and -1 before inoculation had increased mortality and splenic listeria counts. in these mice, thymus weights were ...	1987	3674563
listeria monocytogenes infection with rhombencephalitis.		1987	3681320
t-2 toxin effects on the serum amyloid p-component (sap) response of listeria monocytogenes- and salmonella typhimurium-infected mice.	t-2 mycotoxin, given to mice 4 days prior to an intraperitoneal inoculation with listeria monocytogenes egd, increases the acute phase response as determined by measurements of serum amyloid protein-p (sap), and decreases the severity of the infection. conversely, when t-2 toxin is given simultaneously with l. monocytogenes the mice become more susceptible to the infection, and the sap levels attained are diminished relative to the non-toxin-treated listeria-infected controls. t-2 toxin given 4 ...	1987	3686547
the pathologic and immunologic effects of inhaled acrolein in rats.	four groups of 40 male sprague-dawley rats each were exposed by inhalation to target concentrations of 0, 0.1, 1.0, and 3.0 ppm of acrolein 6 h/day, 5 days/week for 3 weeks. subsequent changes in local pulmonary immunity were determined by examining the number of antibody plaque-forming cells in the lung-associated lymph nodes following intratracheal immunization with sheep red blood cells. separate groups of rats were evaluated for blastogenic responsiveness to phytohemagglutinin-p and salmonel ...	1987	3686549
production of tumor necrosis factor during murine listeriosis.	during a lethal murine infection with the gram-positive bacterium, listeria monocytogenes, a factor appears in the serum that is capable of lysing certain tumor cells in vitro. the levels of this serum cytotoxic factor increase with the progression of morbidity. neutralization of listeria-induced cytotoxic factor activity with a monospecific antiserum to recombinant murine tumor necrosis factor (tnf) revealed that the cytotoxic factor was antigenically indistinguishable from natural tnf present ...	1987	3693903
[meningitis caused by listeria monocytogenes: a rare complication of cushing's syndrome].		1987	3695691
parasite accessory cell interactions in murine leishmaniasis. i. evasion and stimulus-dependent suppression of the macrophage interleukin 1 response by leishmania donovani.	interleukin 1 (il 1) is a principal mediator of the host immune response to microbial challenge. accessory cells of the monocyte-macrophage series are a major source of this cytokine and are also chronically parasitized by protozoa of the genus leishmania. this suggests that characterization of the macrophage il 1 response to leishmania would increase our understanding of the regulation of host immunity to these organisms. in the present study, the macrophage il 1 response to leishmania donovani ...	1987	3493291
the effects of an anti-i-ab antibody on murine host resistance to listeria monocytogenes.	infection with listeria monocytogenes stimulates t cell proliferation and t cell-derived lymphokine production. the release of lymphokines, in turn, "activates" macrophages, enhancing their bactericidal capacity. because prior studies suggest that i-a+ accessory cells play a critical role in this pathway, we assessed the effects of an anti-i-a antibody on the murine host resistance to listerial infection. to this end, we infused listeria into control c57bl/6 mice (i-ab haplotype) and mice of the ...	1987	3494082
comparative antibacterial activity of a new oral cephalosporin, bmy-28100.	bmy-28100 is a new oral cephalosporin which had in vitro activity superior to that of cephalexin and cefaclor against staphylococci, beta-hemolytic streptococcal species, and streptococcus pneumoniae. it inhibited beta-lactamase-producing haemophilus influenzae, neisseria gonorrhoeae, 50% of streptococcus faecalis isolates, listeria monocytogenes, and 50 to 75% of escherichia coli and klebsiella species at less than or equal to 8 micrograms/ml, but high producers of beta-lactamase were resistant ...	1987	3495236
differential protein synthesis by murine peritoneal macrophages elicited by various stimuli.	protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2d page) of 35s methionine-labeled proteins. while the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguished them from the other normal non-macrophage cell types examined, unique proteins also characterized each macrophage population from the others. the accumulation by resident macroph ...	1987	3496410
recombinant murine interleukin-1 alpha enhancement of nonspecific antibacterial resistance.	in this study we report that treatment with recombinant murine interleukin-1 alpha (ril-1 alpha) significantly enhanced the resistance of mice to infection by the facultative intracellular pathogen listeria monocytogenes. the greatest level of protection was observed at a dose of 1,000 lymphocyte-activating factor units (approximately 0.17 micrograms) of ril-1 alpha per mouse. although ril-1 alpha enhanced antibacterial resistance when administered either intravenously or intraperitoneally, grea ...	1987	3497878
passive transfer of acquired resistance to listeria monocytogenes infection is independent of mononuclear cell granuloma formation.	this study documents the formation of leukocyte foci in the livers of mice infused with either normal or immune t cells and then challenged intravenously with listeria monocytogenes. the results show that the transfer of antilisterial resistance occurred before mononuclear cell granuloma formation and was associated instead with the appearance of foci of infiltrating lymphocytes and neutrophils. numbers of these foci remained low in mice which received immune cells but increased progressively un ...	1987	3500132
augmented nonspecific resistance and simultaneous impairment of specific immunity to listeria monocytogenes in tumor-bearing mice.	meth a tumor-bearing mice were examined for changes in the host defense mechanism against infection with listeria monocytogenes. the resistance of tumor-bearing mice to systemic, i.e., intravenous, infection in an early phase of the infection was suppressed for 1-3 days after tumor implantation (5 x 10(5) cells/mouse, subcutaneously), but was augmented thereafter even on the 35th day as compared with normal mice. suppression and enhancement of the resistance of tumor-bearing mice to primary infe ...	1987	3501807
salmonella-typhimurium-specific difference in rate of intracellular killing by resident peritoneal macrophages from salmonella-resistant cba and salmonella-susceptible c57bl/10 mice.	the aim of the present study was to determine whether the difference between the rate of intracellular killing of salmonella typhimurium by macrophages of salmonella-resistant cba and salmonella-susceptible c57bl/10 mice also holds for other salmonellae and other bacteria species. after in vivo phagocytosis, the initial rate of in vitro intracellular killing of s. typhimurium phagetype 505, s. typhimurium phagetype 510, and s. typhimurium m206 by macrophages of cba mice amounted always to approx ...	1987	3295047
listeria monocytogenes arthritis in a renal transplant recipient.		1987	3298461
[treatment of neuro-meningeal listeriosis in patients over 60 with a combination of ampicillin and trimethoprim-sulfamethoxazole].	an open retrospect study, including five patients, has been entered on, in order to estimate the efficacity and the tolerance in a more than sixty years old person, of the association ampicillin-cotrimoxazole for the treatment of the meningitis due to listeria monocytogenes. in the infectious sphere, all the patients recovered; one death, by pulmonary embolism at the 21sh day of evolution, is to be deplored; two erythematous rashes have been observed. these preliminary results are encouraging an ...	1987	3302872
[rational parameters in the treatment of bacterial meningitis with modern cephalosporins].	modern cephalosporins are by now well established therapeutic drugs in the treatment of bacterial meningitis. particularly for gram-negative meningitis they are valuable therapeutic tools. in most cases, they are very efficient and less toxic than former therapeutic regimens. of course, they cannot replace penicillin g in the therapy of meningitis with penicillin-sensitive bacteria. the advantages and disadvantages of the single compounds, cefotaxime, latamoxef, ceftizoxime, cefmenoxime, ceftazi ...	1987	3312038
chemotherapy for bacterial infections of the central nervous system.	over the past six years, many new agents have become available for the treatment of bacterial central nervous system (cns) infections. certain principles guide the use of these agents for cns infections: first, an antimicrobial agent must be able to penetrate the cns to be effective; second, the cns is a "relatively immunoincompetent site" so that an antimicrobial must achieve levels within the cns capable of killing the offending bacterium. the lack of efficacy of chloramphenicol for meningitis ...	1987	3314156
cephalosporins in the treatment of meningitis.	the synthesis of new cephalosporin antibiotics has provided agents which can effectively be used to treat most of the different forms of meningitis. none of the first generation cephalosporins can be considered acceptable as agents to treat meningitis. cefuroxime can be used to treat meningitis due to streptococcus pneumoniae, haemophilus influenzae and neisseria meningitidis in children. agents such as cefotaxime and ceftriaxone are appropriate for neonatal meningitis due to escherichia coli an ...	1987	3319497
the role of interleukin 1 and 2 in generation of acquired resistance against mouse typhoid infection afforded by dialyzable factor from salmonella typhimurium.	dialyzable factor (df) prepared from a ribosomal fraction of salmonella typhimurium was tested for its ability to induce interleukin 1 (il 1) and 2 (il 2) production, in relation to acquired resistance, after an intraperitoneal injection of df. il 1 production in vitro by peritoneal macrophages of df-treated mice reached the maximum 4 days after injection, at the time when the nonspecific local resistance via macrophages directly activated with df became apparent (kita et al, microbiol. immunol. ...	1987	3323855
[infection by listeria monocytogenes after a renal transplant. report of 6 cases].		1987	3329762
[listeriosis today].		1987	3102201
pharmacokinetic and in vivo studies with azithromycin (cp-62,993), a new macrolide with an extended half-life and excellent tissue distribution.	azithromycin (cp-62,993), a new acid-stable 15-membered-ring macrolide, was well absorbed following oral administration in mice, rats, dogs, and cynomolgus monkeys. this compound exhibited a uniformly long elimination half-life and was distributed exceptionally well into all tissues. this extravascular penetration of azithromycin was demonstrated by tissue/plasma area-under-the-curve ratios ranging from 13.6 to 137 compared with ratios for erythromycin of 3.1 to 11.6. the significance of these p ...	1987	2830841
effect of leukocyte and other tissue dialysates on nbt reduction and prostaglandin production in mice.	the effects of human leukocyte, porcine spleen and bovine liver dialysate fractions on listeria resistance were measured by survival studies and by assessing the capacity of peritoneal macrophages to produce superoxide anion (0-2) and prostaglandins. leukocyte (dle) and other tissue dialysates were fractionated on a sephadex g-10 column. thereafter the significant activities were found in fraction iii of dle, fraction ii of porcine spleen and fraction ii + iii of bovine liver dialysate. the trea ...	1987	2831694
analysis of colony-stimulating factors and macrophage progenitor cells in mice immunized against listeria monocytogenes by adoptive transfer.	experiments were performed to elucidate the role of colony-stimulating factors in host defenses to the intracellular pathogen listeria monocytogenes. mice were protected against listeria sp. by adoptive transfer of immune spleen cells and were then challenged with listeriae intravenously. control mice were injected with spleen cells from uninfected mice. adoptively immunized (immune) mice had significantly fewer listeriae in spleens and livers 2 and 4 days after listeria challenge than did contr ...	1987	2886433
the immunoregulatory role of the macrophage.		1987	2951389
in vitro activity of a-56268 (te-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms.	the in vitro activity of a-56268 was determined and compared with that of erythromycin and clindamycin against a limited spectrum of 401 gram-positive and gram-negative organisms. a-56268 was quite active against erythromycin-susceptible staphylococcus aureus, neisseria gonorrhoeae, listeria monocytogenes, streptococcus pneumoniae, streptococcus pyogenes, and group b streptococci and was moderately active against campylobacter fetus subsp. fetus. a-56268 was consistently bactericidal only for s. ...	1987	2952063
suppression of immune response in the b6c3f1 mouse after dietary exposure to the fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone.	the effect that dietary exposure to the naturally-occurring fusarium graminearum toxins deoxynivalenol (don) and zearalenone (zea) may have on immune function was assessed in the b6c3f1 mouse. dietary don depressed the plaque-forming response to sheep red blood cells, the delayed hypersensitivity response to keyhole limpet haemocyanin and the ability to resist listeria monocytogenes. listerial resistance was similarly decreased in control mice fed restricted diets comparable to the dietary restr ...	1987	2953660
comparative in vitro activity of a-56268 (te-031) against gram-positive and gram-negative bacteria and chlamydia trachomatis.	the in vitro activity of a-56268 (te-031) was determined and compared with that of 13 antibiotics against 401 gram-positive and gram-negative bacteria and 11 strains of chlamydia trachomatis. a-56268 was very active against methicillin-susceptible staphylococcus aureus and neisseria gonorrhoeae, and was among the most active of the agents tested against listeria monocytogenes, streptococci and chlamydia trachomatis. it was moderately active against haemophilus spp., vibrio spp., campylobacter je ...	1987	2954818
regression analysis, proposed interpretative zone size standards, and quality control guidelines for a new macrolide antimicrobial agent, a-56268 (te-031).	a-56268 is a 6-o-methyl derivative of erythromycin a which has a spectrum of activity similar to that of erythromycin and is 1 log2 dilution more potent than erythromycin against most organisms that have been tested. the correlation of zone size diameters and mics of a-56268 for 461 strains of bacteria isolated from clinical specimens was investigated. based on anticipated levels in human serum of 2 micrograms/ml, 15-microgram disks have been recommended with zone size standards of greater than ...	1987	2954995
bactericidal activity and killing rate of serum in volunteers receiving vancomycin or teicoplanin with and without amikacin given intravenously.	we have studied the interaction between vancomycin or teicoplanin and amikacin in two groups of five volunteers randomized to receive either (a) vacomycin, amikacin, vancomycin+amikacin, or (b) teicoplanin, amikacin, teicoplanin+amikacin. each administration was given on separate days, in random order with a 48 hours washout period between each infusion. the serum concentrations measured microbiologically at time 0, 1 and 6 h were: 42.6, 11.4 and 4.1 mg/l respectively for teicoplanin; 27.6, 13.9 ...	1987	2956228
immunological studies on mice exposed subacutely to methyl isocyanate.	the immunotoxicity of methyl isocyanate (mic) was evaluated in female b6c3f1 mice exposed via inhalation to 0, 1, or 3 ppm for 6 hr per day on 4 consecutive days. the antibody response to sheep erythrocytes and natural killer cell activity were found to be unaffected by mic exposure. although lymphoproliferative responses to mitogens were moderately suppressed by mic, the differences were not statistically significant. the response of splenic lymphocytes to allogeneic leukocytes in a mixed leuko ...	1987	2957195
divergent changes in antimicrobial activity after immunologic activation of mouse peritoneal macrophages.	to find out whether activated macrophages display a nonspecific enhancement of antibacterial activity, we determined the intracellular killing of bacteria by peritoneal macrophages from cba and c57bl/10 mice infected with bcg and challenged with mycobacterial antigens (purified protein derivative (ppd]. after in vivo phagocytosis, the rate of in vitro intracellular killing of listeria monocytogenes by bacillus calmette-guérin (bcg)-ppd-activated macrophages from cba mice increased by a factor of ...	1987	2957432
inability of recombinant interferon-gamma to activate the antibacterial activity of mouse peritoneal macrophages against listeria monocytogenes and salmonella typhimurium.	the effect of recombinant murine interferon-gamma (rifn-gamma) as single stimulus for the activation of antibacterial activity of macrophages was investigated on the basis of the rate of intracellular killing of listeria monocytogenes and salmonella typhimurium by normal and rifn gamma-activated peritoneal macrophages of cba and c57bl/10 mice, which differ in natural resistance to infection by these bacteria. eighteen hours after i.p. injection of 10 to 1 x 10(4) u rifn-gamma, resident and exuda ...	1987	2957433
possible role of helper and cytolytic t lymphocytes in antibacterial defense: conclusions based on a murine model of listeriosis.	murine t cell clones with specificity for the intracellular bacterium listeria monocytogenes were used in an attempt to analyze the relative roles of helper and cytolytic t lymphocytes in antibacterial immunity. after stimulation by antigen and accessory cells, l. monocytogenes-specific, l3t4+, class ii-restricted t cells produced multiple lymphokines, including interleukin 2 and interferon-gamma (ifn-gamma). cloned t cells could help b lymphocytes differentiate into antibody-secreting cells and ...	1987	2961041
listeria brain abscess associated with steroid therapy: successful non-surgical treatment.	a patient is reported who developed a brain abscess due to listeria monocytogenes while on long-term steroid therapy and who was successfully treated medically without surgical intervention. the literature on listeria brain abscess is reviewed, and the importance of early recognition of this infection in any immunocompromised patient who develops focal cerebral dysfunction is emphasised.	1987	3077339
pathogenicity test for listeria monocytogenes using immunocompromised mice.	the lethality of listeria isolates was determined with normal adult mice and mice that were immunocompromised by treatment with 20 mg of carrageenan per kg. the mean 50% lethal doses (ld50s) of the pathogenic isolates were significantly lower (alpha = 0.05) in the immunocompromised mice than in the untreated mice, with an average reduction of 5.8 log10 units. in contrast, the mean ld50s of the nonpathogenic isolates were lower in the immunocompromised mice by an average of only 0.4 log10 unit, a ...	1987	3121665
listeria monocytogenes atcc 35152 and nctc 7973 contain a nonhemolytic, nonvirulent variant.	listeria monocytogenes nctc 7973 and this same strain deposited as atcc 35152 contain two phenotypes: hemolytic virulent colonies and nonvirulent colonies that show no zones of hemolysis when streaked on heart infusion agar containing 5% rabbit blood. results of examinations of these virulent and nonvirulent strains by investigators at the centers for disease control, atlanta, ga., the pasteur institute, paris, france, and the university of würzburg, federal republic of germany, support the conc ...	1987	3121669
[congenital listeriosis].		1987	3122163
control of listeria in the dairy plant.		1987	3111073
t-2 toxin-enhanced resistance against listeriosis in mice: importance of gastrointestinal lesions.	the role of t-2 toxin-induced gastrointestinal lesions in t-2 toxin-enhanced resistance to listeriosis in mice was evaluated. the t-2 toxin-induced lesions did not cause a starvation effect sufficient to enhance resistance to listeriosis. administration of polymyxin e markedly reduced the gram-negative intestinal microflora and did not eliminate the toxin-induced resistance to listeriosis. the t-2 toxin did not cause an increased expression of ia surface antigens on peritoneal macrophages. thus, ...	1987	3111316
comparison of media and methods for detecting and enumerating listeria monocytogenes in refrigerated cabbage.	direct plating, selective enrichment, and cold enrichment followed by secondary selective enrichment procedures were compared for detecting and enumerating listeria monocytogenes in chopped cabbage stored at 5 degrees c for up to 64 days. addition of fe3+ to solid media enhanced detection of the organism. cold enrichment (5 degrees c) in nutrient broth and brain heart infusion broth followed by secondary enrichment (48 h, 30 degrees c) in trypticase soy-yeast extract-antibiotic broth and thiocya ...	1987	3111369
3rd forum de microbiology. virulence of listeria monocytogenes.		1987	3111507
purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin o from listeria monocytogenes.	we purified and characterized an extracellular hemolysin produced by listeria monocytogenes. hemolysin production was greatly enhanced by growing bacteria in resin (chelex)-treated medium. this hemolysin was separated as a homogeneous protein of 60,000 daltons by using thiol-disulfide exchange affinity chromatography. this protein was a sulfhydryl-activated toxin, termed listeriolysin o, which shared the classical properties of other bacterial sulfhydryl-activated toxins: inhibition by very low ...	1987	3110067
immunosuppressive effect of cyclosporin a on mycobacterium bovis bcg infections in mice.	the effect of increasing doses of cyclosporin a (csa) given to mice infected intravenously with mycobacterium bovis bcg was investigated. development of both tuberculin hypersensitivity and acquired antituberculous resistance was suppressed in a dose-responsive manner. daily dosages at 100 mg/kg of body weight prevented any reduction in the bcg counts within the lungs, liver, or spleen. this effect was associated with lowered nonspecific resistance to a listeria monocytogenes challenge and a dec ...	1987	3110069
failure of recombinant murine gamma-interferon to cure chronic listerosis of nude, athymic mice.	the bacterial counts per spleen of athymic, nude mice chronically infected with listeria monocytogenes could not be reduced by treatment with high doses of recombinant murine gamma-interferon.	1987	3122379
[fulminant hepatitis in listeria septicemia].	we report on a 44-year-old male patient admitted with acute severe icteric hepatitis. listeria monocytogenes was isolated from blood cultures. the further course was complicated by meningitis and the patient finally died of multiorgan failure. autopsy revealed nodular cirrhosis of the liver with cholestatic hepatitis and focal subacute liver dystrophy, as well as granulating meningitis. the case is discussed in the context of five previously published observations on hepatitis due to listeria mo ...	1987	3124266
a simple method for evaluation of delayed hypersensitivity in mice.		1987	3125573