Publications

kinetics of the interaction of bovine pancreatic trypsin inhibitor (kunitz) with alpha-chymotrypsin.		1974	4857588
discoidin, a developmentally regulated carbohydrate-binding protein from dictyostelium discoideum. purification and characterization.		1974	4858710
antimicrobial susceptibility of haemophilus influenzae.	selected clinical isolates of haemophilus influenzae were tested for their susceptibility to seven antibiotics by a microtiter broth dilution and an agar diffusion method. eleven of 40 strains tested were resistant to ampicillin, the drug of choice, by both methods. all the strains tested were susceptible to chloramphenicol, and all but one were susceptible to tetracycline. of the other four antibiotics tested, the ranges of minimal inhibitory concentrations (mics) were: 0.5 to 4 mug of gentamic ...	1974	15825316
beta-lactamase activity in ampicillin-resistant haemophilus influenzae.	the specific activity, substrate profile, response to inhibitors, inducibility, and cellular localization of the beta-lactamase produced by an ampicillin-resistant strain of haemophilus influenzae type b were investigated. in these properties the enzyme resembles beta-lactamases produced by other gram-negative bacilli more closely than those produced by gram-positive organisms. it is quite similar to an enzyme found in strains of klebsiella pneumoniae, and differs significantly from those descri ...	1974	15825317
ampicillin resistance in haemophilus influenzae as determined by a rapid test for beta-lactamase production.	a rapid capillary tube method was used to demonstrate beta-lactamase production by ampicillin-resistant strains of haemophilus influenzae.	1974	15825323
in vitro susceptibility of haemophilus influenzae to eight antibiotics.	freshly isolated strains of haemophilus influenzae type b were studied for their in vitro susceptibility to eight antibiotics with a low concentration inoculum. no organisms were identified as being resistant to ampicillin, but minimal inhibiting concentrations for that antibiotic were somewhat higher than reported previously for a similar method. carbenicillin and ticarcillin resembled ampicillin in activity, and the three agents were more effective on a weight basis than the other agents teste ...	1974	15828179
the nucleotide sequence preceding an rna polymerase initiation site on sv40 dna. part 1. the sequence of the late strand transcript.	the nucleotide sequence of the transcript of the "late" strand of the region of sv40 dna preceding the preferred initiation site for escherichia coli rna polymerase has been determined to be u-g-u-a-a-c-c-a-u-u-a-u-a-a-g-c-u-g-c-a-a-u-a-a-a-c-a-a-g-u-u-a-a-c-a-a-c-a-a-c-a-a-u-u-g-cp. hemophilus influenza restriction endonuclease cleaves this region 30 nucleotides (base pairs) before the site of initiation of rna synthesis by rna polymerase.	1974	10793741
the nucleotide sequence preceding an rna polymerase initiation site on sv40 dna. part 2. the sequence of the early strand transcript.	the nucleotide sequence of the rna transcript from the "early" (e) strand of sv40 dna immediately preceding the preferred e. coli rna polymerase start site is g-(a-a-a-c, -a-u-)-a-a-a-a-u-g-a-a-u-g-c-a-a-u-u-g-u-u-g-u-u-g-u-u-a-a-c-u-u-g-u-u-u-a-u-u-g-c-a-g-c-u-u-a-u-a-a-u-g-g-u-u-a-c-ap. the last nucleotide of the sequence is the first nucleotide transcribed by e. coli rna polymerase from the "e" strand. the dna template contains a palindrome of 17 residues that includes the hemophilus influenz ...	1974	10793742
residues of tetrachloronitrobenzene and related compounds in potatoes.		1974	444752
transporting high risk infants.		1974	355691
glyceryl trioleate-water partition coefficients for three simple organic compounds.		1974	444710
screening of common bacteria capable of demethylation of methylmercuric chloride.	in summary, 21 bacteria were capable or degrading methylmercury chloride as measured by the disappearance of that species from the soil culture media. disappearance of the methylated form was also accompanied by loss of total mercury in the culture media--probably as a result of reduction of the initial metabolite to volatile hgo. the role of bacteria in the reduction step is not clear at this time although several authors (summers et al. 1972 and 1973; bisogni and lawrence 1973 ) have suggested ...	1974	444703
a method of decontamination of ultrasonic scalers and high speed handpieces.	the use of contaminated water in high speed handpieces and ultrasonic handpieces presents potential hazards to both dentist and patient. this study has shown that after waterline sterilization, the use of a sterile, disposable membrane filter can eliminate the microflora from the water of an ultrasonic scaler for up to 48 hours. similarly, the water from a high speed handpiece can remain bacteria free for up to 72 hours when a 0.45 micrometer pore size membrane filter is installed into the water ...	1974	355619
[the solution lies in education].		1974	245857
[bronchial asthma associated with primary lung cancer--comparison of extrathoracic malignancies].	regarding 249 bronchial asthma patients having been admitted to our division for the recent 9 years, clinical manifestations of 8 bronchial asthma with primary lung cancer (group a; squamous cell carcinoma--5 cases, adenocarcinoma--2 cases, small cell carcinoma--1 case; 3.2% of 249 cases) and 8 asthma patients with extrathoracic malignancy (group b; gastric cancer--3 cases, malignant lymphoma--2 cases, bladder cancer--1 case, laryngeal cancer--1 case, prostatic cancer--1 case) were investigated. ...	1974	1648900
a condemned man's last wish: organ donation & a 'meaningful' death. commentary.		1974	429055
prevalence of trunk abnormalities in eleven-year-old schoolchildren in rotterdam, the netherlands.	the prevalence of trunk abnormalities was studied in 4,915 children aged 11 years (2,528 boys, 2,387 girls); 33% of the children were of non-dutch origin. the following measurements were recorded: height, weight, signs of puberty, and menarche. trunk abnormality was assessed in the erect child (asymmetry of shoulders, waistline, imbalance of the trunk, scoliosis, lordosis, kyphosis, swayback, and flexibility) and by the forward bending test (rib hump or lumbar prominence, persistence of scoliosi ...	1974	1613091
bilateral severe carotid stenosis or occlusion and computed tomographic scan positive hemispheric stroke with neurologic deficit: immediate contralateral carotid endarterectomy.	in the last 10 years, 13 patients presented with acute, hemispheric, computed tomographic scan-positive stroke; neurologic deficit; and bilateral carotid stenosis greater than 90% (n = 9) or ipsilateral occlusion with contralateral stenosis greater than 90% (n = 4). to improve ipsilateral flow without elevation of pressure to levels causing hemorrhagic infarction, all patients underwent carotid endarterectomy on the side contralateral to the hemispheric stroke from two to 10 days (average 6.6 da ...	1974	1610656
nightmare prevalence in the healthy elderly.	fifty-one healthy elderly subjects (median age = 65) gave retrospective estimates of nightmare frequency in questionnaires and recorded the occurrence of nightmares in daily logs over a 2-week period. (a) mean annual nightmare frequency as estimated from logs was only 65% as high among college student controls. (b) elderly subjects were about 1/5 as likely as college students to report a problem with nightmares. (c) frequency estimates on the basis of logs were over 10 times higher than retrospe ...	1974	1610522
past substance abuse and clinical course of schizophrenia.	to evaluate the effects of previous alcohol and drug use on the course and symptoms of schizophrenia, the authors compared 34 patients with schizophrenia who had histories of substance abuse with 17 patients with schizophrenia who were lifelong abstainers. surprisingly, they did not find that individuals with past histories of abuse were more impaired or had more symptoms.	1974	1554046
rules for ring closure.	the ease of formation of cyclic structures shows some regularity which can be described by a set of 'rules' for ring closure. the restrictions on the endocyclic transfer of groups due to sn2 displacements having linear transition states are exemplified by studied on a biogenetic type synthesis of penicillin and, more generally, on the endocyclic attack of a nucleophile attached by a linking chain to an enone or polarized double bond. the formation of five-memebered rings is considered. in base, ...	1974	246784
bradyarrhythmias requiring pacemaker implantation after orthotopic heart transplantation: association with rejection.	patients with severe sinus-node dysfunction that required pacemaker implantation after orthotopic heart transplantation were reviewed. during a 21-month period, 42 transplantations were performed in 41 patients. five patients (12.2%) required a permanent pacemaker because of severe dysrhythmias. three patients had moderate-to-severe cellular and/or humoral (vascular) rejection, and two of the five patients (40%) died. in the remaining two patients, bradyarrhythmias were due most likely to trauma ...	1974	1610853
[post-puberty endometrial dystrophies].		1974	478099
national academy of clinical biochemistry kodak lectureship award recipient.		1974	1633630
pa2 and receptor differentiation: a statistical analysis of competitive antagonism.		1974	388133
a clinical teacher looks at nurse education.		1974	246572
should employers be given the chance to remedy poor standards of care before a whistleblower goes public?		1974	1633089
evaluation of the impact of dissemination of smoking cessation methods on the low birthweight rate and on health care costs: achieving year 2000 objectives for the nation.	nationwide dissemination of efficacious and cost-effective smoking cessation methods during the 1990s represents an important part of the solution to reducing the low birthweight (lbw) rate and associated health care costs. a minimum of 250,000 lbw births must be prevented during the 1990s to achieve the year 2000 lbw rate objective of 5% of total births. annually 1,500 to 6,000 lbw births might be prevented between 1991 and 2000, and cumulatively 29,000 to 44,000, by dissemination of tested smo ...	1974	1633005
long-term evaluation of the porcine xenograft bioprosthesis.		1974	470415
levels of blood glucose and tissue glycogen in two live fish exposed to industrial effluent.		1974	444704
pulp biology conference: a discussion.		1974	355593
who is deprived?		1974	245672
[inclusion of the circumstances and the mental process of the nurse in the nursing record].		1974	246767
'meningitis by the score'.		1975	664
current status of treatment of pneumonia.	proper treatment of pneumonia is dependent upon a correct diagnosis. pneumonia may be due to infectious agents, allergic phenomena, or chemical causes. treatment regimens are outlined for the various types of pneumonia--pneumococcal, staphylococcal, fungal, and pneumonia due to gram-negative and anaerobic gram-negative bacilli, to blastomyces dermatitidis, and to the parasite pneumocystis carinii. in discussing current concepts of treatment, several well-known methods are emphasized, as well as ...	1975	792
comparative study of virological infections in asthmatic and nonasthmatic children.	the author shows complex analyses: clinical, laboratory, x-rays, bronchoscopical, bronchographical and measuring lung function tests as well as the serological examinations in blood serum of both groups of asthmatic and nonasthmatic children with virological infection. the calculation of statistically significant differences between the various diagnostical results of both groups has confirmed that in asthmatic children virological infection of the respiratory tract, pathological findings in x-r ...	1975	884
acute otitis media. a clinical bacteriological and serological study of children with frequent episodes of acute otitis media.	a series of episodes of acute otitis media was studied with reference to bacterial findings and specific serological responses in 48 children with histories of frequent episodes before. d. pneumoniae and h. influenzae were the most frequently isolated pathogens. re-isolations after therapy were often made in episodes with slow healing or therapeutic failure. most children harboured pathogens in nasopharynx even when they had no signs of respiratory tract infections. homologous relapses were seen ...	1975	885
editorial: bronchiectasis today.		1975	1138
the influence of bacterial superinfection on the clinical course of influenza. studies from the influenza epidemics in stockholm during the winters 1969-70 and 1971-72.	during two epidemics of influenza a infection in stockholm 1969-72, 249 cases were selected for a study on the effect of bacterial superinfection. bacterial involvement was demonstrated through cultures and serologic reactions. the occurrence of c-reactive protein in increased amount in serum was significantly more common in the group which had the strongest indication of bacterial infection. an increased duration of fever, and a higher incidence of pneumonia, leukocytosis and erythrocyte sedime ...	1975	1847
evaluation of the antibiotic effect of treatment of maxillary sinusitis.	as the effect of antibiotic treatment of maxillary sinusitis has been questioned, the elimination of bacteria from sinus secretions was studied during antibiotic treatment. penicillin v, azidocillin, tetracycline or doxycycline was administered to 54 patients with maxillary sinusitis. samples of sinus secretion were aspirated both before treatment and 2-3 days after the onset of treatment. when the antibiotic concentration was below the upper limit of mic for sensitivity group 1, bacterial growt ...	1975	1848
proceedings: long-term therapy with antibiotics in chronic bronchitis.	longterm therapy of chronic bacterial bronchitis assumes two forms: (a) therapy of acute exacerbations, and (b) continuous longterm prophylaxis, chiefly during the 4-7 winter months. longterm prophylaxis should be confined exclusively to patients with two or more severe annual exacerbations. the commonest pathogens, haemophilus influenzae and pneumococci, are usually sensitive to ampicillin and amoxycillin, cotrimoxazole (bactrim or eusaprim) and tetracyclines.	1975	2971
bacteriological examinations of bronchial secretion in children with non-specific bronchopulmonary disease (author's transl).	one thousand specimens of bronchial secretion from children with non-specific respiratory diseases have been examined bacteriologically. in spite of the complex nature of acute and especially of chronic respiratory disease the role of bacterial infection should not be underestimated. thirty per cent of the specimens were sterile. more than 20 per cent of the bacterial species isolated from bronchial secretion were pathogenic. relatively frequent was the isolation of e. coli and of pathogenic sta ...	1975	5823
bacterial meningitis in infancy and childhood in lusaka (one year prospective sturdy).	in approximately 10,000 admissions in a 12 months period, at university teaching hospital, lusaka 85 cases of meningitis were recorded. the signs and symptoms in these patients do not greatly differ from other similar studies in africa. the commonest organism isolated was pneumococcus. there was high mortality rate which was to a large extent due to parents not bringing their children to hospital early enough for medical treatment to be instituted. this is borne out by the fact that 50% of the c ...	1975	5834
bacteriologic flora of aspiration-induced pulmonary infections.	the role of anaerobic and aerobic microorganisms in the genesis of pneumonia or lung abscess in patients with historical, clinical, and radiologic findings suggestive of aspiration was compared to their role in similar patients without these findings. bacterial specimens were obtained by transtracheal aspiration or thoracentesis. anaerobes were isolated in 100% of the patients who were aspiration-prone as contrasted with only 20% of those who were not. isolation of a single species or no growth ...	1975	28705
thermal denaturation of dna in situ as studied by acridine orange staining and automated cytofluorometry.		1975	46199
editorial: antimicrobial treatment of chronic bronchitis.		1975	46968
letter: chloramphenicol resistance in haemophilus species.		1975	47130
ampicillin-resistant haemophilus influenzae type b possessing a tem-type beta-lactamase but little permeability barrier to ampicillin.	ampicillin-resistant haemophilus influenzae type b have been reported only during the past year. five clinical isolates from the u.s. and germany all had the tem-type beta-lactamase which is known to be transferred widely among other gram-negative bacilli. unlike those bacilli, however, the h. influenzae cell had very little barrier to entry of penicillins. this greater permeability of the h. influenzae cell to penicillins appeared to reduce the protective effect of its beta-lactamase, in that a ...	1975	47483
induction of serum haemophilus influenzae type b capsular antibodies in adult volunteers fed cross-reacting escherichia coli 075:k100:h5.	serum haemophilus influenzae type b (hitb) anticapsular antibodies were induced in adult volunteers by feeding of either of two strains of a cross-reacting escherichia coli 075:k100:h5. in all the fed volunteers colonization for a finite period lasting up to eight weeks occurred, without adventitious reactions. nine of 14 normal volunteers and one of two volunteers previously immunized with the type 6 h.influenzae polysaccharide responded with a greater than twofold increase in serum type 6h. in ...	1975	48191
release of histamine from rat mast cells by the complement peptides c3a and c5a.	suspensions of rat mast cells were used to study the histamine-releasing actions of anaphylatoxins c3a and c5a in vitro. the peptides, derived from human or porcine complement proteins c3 and c5, were less potent than 48/80 but more potent than bradykinin in stimulating release of histamine from mast cells. the pattern of release resembled that of the anaphylactic release action, e.g. release was limited to less than 30 per cent of the cell histamine, the reaction was calcium-dependent and was p ...	1975	48505
[determination of proteolytic activity of human stomach and duodenum in situ].		1975	48576
letter: ampicillin-resistant haemophilus influenzae in otitis media.		1975	49485
editorial: prevention of haemophilus influenzae meningitis.		1975	49657
immunological study of anthranilate synthetase.	an immunological study of anthranilate synthetase (asase) has been initiated using quantitative precipitation, enzyme neutralization, and immunodiffusion methods. cross-reactivity of anthranilate synthetase-anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase (asase-prtase) from escherichia coli, klebsiella aerogenes, and salmonella typhimurium and asase from serratia marcescens and pseudomonas putida was detected with antibodies to ?e. coli trypsin-treated asase. cross-reactivit ...	1975	50316
haemophilus influenzae type b resistant to tetracycline isolated from children with meningitis.	during a three-year-period, 1971-73 inclusive, haemophili isolated from 96 children with severe infections, of whom 73 had meningitis and 19 acute epiglottitis, were serotyped and tested for sensitivity to antibacterial drugs. all strains were identified as haemophilus influezae type b, and were sensitive to ampicillin, chloramphenicol, and trimethoprim. however, 3 isolates--from a boy aged 11 months and a girl aged 1 year with meningitis, and a girl aged 2 years with epiglottitis--were highly r ...	1975	53373
changing patterns of bacterial resistance in relation to prophylactic use of cephaloridine and therapeutic use of ampicillin.	antibiotic sensitivities of 15302 organisms of common pathogenic species isolated in one hospital pathology department in 1971 and 1974 have been studied. resistance to cephaloridine did not change materially. the proportion of strains resistant to ampicillin did, however, increase, and this is attributed to the widespread therapeutic use of the antibiotic. cephaloridine, on the other hand, was largely used in the hospital as a single-dose, intra-incisional prophylactic against surgical wound se ...	1975	53736
cell-mediated immune response in mice treated with steroidal contraceptives.	the splenomegaly assay (simonsen, 1962) was standardized using different strains of rats and mice. male wistar rat (donor)-female swiss mouse (host) was found to be the suitable combination that could be employed in subsequent experiments to study the potential of contraceptive steroids to alter cmir. the index of splenomegaly appeared to increase in case of mice treated with combination oral contraceptives (ovulen, ovral or enovid). the differences observed, however, neared significance only in ...	1975	55327
retention and redistribution of proteins in mammalian nerve fibres by axoplasmic transport.	fast axoplasmic transport is characterized by a crest of labelled activity moving down nerve fibres after injection of the l7 dorsal root ganglion with the amino acid precursor (3h) leucine, the crest followed by a plateau which represents in part a later egress of labelled components from compartments in the cell bodies and in part materials left behind the advancing crest. 2. after making ligations just below the ganglia at different times after injection of the precursor, a small downward slo ...	1975	55480
[microflora of sputum from patients with acute pneumonia].		1975	56516
inhibition of leucyl-trna synthetase in escherichia coli by the cytostatic 5,8-dioxo-6-amino-7-chloroquinoline.	at concentrations of 1-1.6 mug/ml, 5,8-dioxo-6-amino-7-chloroquinoline causes auxotrophy for leucine in escherichia coli mre 600. with increasing concentrations of this quinone additional amino acids are required for growth. the amount of leucine in the pool of free amino acids is not decreased after treatment of e. coli with the quinone. transfer rnaleu, however, is charged with leucine less than 10% in quinone-treated cells of e. coli, whereas in control cells the degree of aminoacylation is a ...	1975	95889
[exploration of parotid saliva proteins by means of one-and-two-dimensional immunelectrophoresis, immunodiffusion and discelectrophoresis (author's transl)].	the protein composition of human parotid saliva was explored by means of one- and two-dimensional immunelectrophoresis as well as by a modified ouchterolony-technique and discelectrophoresis, where usually at least 14 components of parotid-saliva-proteins can be differentiated. according to the results of immunelectrophoresis and discelectrophoresis, the kind and number of protein components are interindividually constant, yet, there are great interindividual differences concerning the concentra ...	1975	123615
micrococcus lysodeikticus atpase. purification by preparative gel electrophoresis and subunit structure studied by urea and sodium dodecylsulfate gel electrophoresis.	micrococcus lysodeikticus atpase was purified by preparative gel electrophoresis after its "shodk wash" release from the membrane. the method afforded the highest yield of pure protein in the minimum time as compared with former purification procedures. the pure protein had a specific activity of 7 mumol pi-min- minus 1-mg- minus 1 with incubation times not longer than 3 min, 345 000 mol. wt and was not stimulated by trypsin. by gel electrophoresis at alkaline ph (8.5) in 8 m urea or in sokiu ...	1975	123783
evidence that the deferential vein acts as a local transport system for androgen in the rat and the dog.	ligation of the deferential vein of the rat has been shown to bring about a reduction in the androgen-dependent activity of the prostatic rna polymerase enzyme. in the dog, the content of androgens in this vein is of the order of that found in the testicular vein and many times higher than that of peripheral plasma. it seems that the cauda epididymidis alone is sufficient to maintain the ipsilateral lobes of the prostate and seminal vesicles providing an intact ductus deferens and contralateral ...	1975	123961
fatal immune complex glomerulonephritis without deposits.	repeated intravenous injections of egg albumin in rabbits produced small antigen-excess complexes and severe glomerulonephritis. immunoglobulins and complement in the glomeruli were not clearly demonstrated by immunofluorescence; deposits were found to be sparse by electron microscopy. this study demonstrates that soluble immune complexes are responsible for the glomerular reaction. the apparent absence of deposits is thus not sufficient to exclude an immune complex pathogenesis.	1975	123971
fenfluramine-induced enhancement of confinement motor activity: an indirect 5-hydroxytryptamine-like action?		1975	124023
an (8;12) translocation, balanced, 46 chromosomes. repository identification no. gm-213.		1975	124242
suspected "b"-vitamin deficiency of sheep fed a protein-free urea containing purified diet.		1975	124720
editorial: acne, soap and chocolate.		1975	125375
inhibition not facilitation of sexual behavior by pcpa.	it has been proposed that estrous behavior in the female rat may be under tonic inhibition by a central serotonergi system. studies conbining estrogen priming and the pharmacological depletion of serotonin have provided some support for this hypothesis. some evidence, however, is not consistent with this hypothesis. in the present study estrogen primed ovariectomized-adrenalectomized rats were administered p-chlorophenylalanine and were tested for lordosis behavior 66 and 70 hr later. lordosis w ...	1975	125426
activation and inactivation of rat liver phosphofructokinase by phosphorylation-dephosphorylation.		1975	126176
variable nature of cartilage proteoglycans.	cartilage proteoglycan aggregates are separated from collagen and other non-proteoglycan protein by preparative rate zonal sedimentation under associative conditions. dissociative rate zonal sedimentation produces sedimented proteoglycan of lower protein content with a corresponding increase in the amount of less sedimentable protein-rich proteoglycan. an extensive number of sequential rate zonal sedimentations discloses that the proceess of disaggregation involves the separation of proteoglycan ...	1975	126234
[changes in ventilatory patterns before and after vagotomy in rabbits].	ventilatory pattern have been investigated during rebreathing experiments. before vagotomy, a linear relation has been found between increasing tidal volume and decreasing inspiratory and expiratory durations. after vagotomy, these relations existed but expiratory duration remained almost constant.	1975	126729
[strontium and calcium metabolism. interaction of strontium and vitamin d].	oral administration of strontium to calcium wellfed rats blocks the intestinal absorption of calcium. when high doses of vitamine d are given over long period, the inhibition of calcium intestinal absorption disapears. under these conditions the absorption of strontium is increased. it is suggested that there is only one absorption mechanism for these two cations. an overdose of the vitamine d increases the renal elimination of strontium but under these conditions the plasma concentration of the ...	1975	126763
[optical microscopic study of the effect of the hypothalamic hormone t.r.h. on certain cell types of rat anterior hypophysis].	a cytological and optical microscopic study of the anterior lobe of hypohysis in the wistar adult rat 10, 30 or 60 minutes after intravenous injection of 50 mug of synthetic trh discloses modifications of thyrotropic cells and prolactin cells. it's possible to recognize a quick degranulation of the prolactin cells (with a maximum at the 10th minute) and a slower degranulation of the thyrotropic cells (perceptible at the 10th minute and very pronounced at the 60th minute). the somatrotopic cells ...	1975	126765
[electrofocusing of hydrolases in rat brush border enterocytes].	different hydrolases (cellobiase, enterokinase, lactase, leucine aminopeptidase, alcaline phosphatase and trehalase) of the brush border's enterocytes of the rat have been studied by electrofocusing. every hydrolase is focused in a single peak, the pi of which is given.	1975	126772
[effect of a beryllium complex on growth of pseudomonas fluorescens (types r and s). i. influence on the lag phase].	the toxicity of beryllium for pseudomonas fluorescens is studied with the aid of an anionic complex of the element which is stable in peptone medium at ph 6 during the period of investigation. the toxic effect is characterized by an increase in the lag phase which is proportional to the square of the beryllium concentration. further, a process of progressive adaptation is observed when the concentration of the beryllium complex is gradually increased.	1975	126778
letter: safety of retinoic acid in acne therapy.		1975	126796
effect of methysergide, a blocker of serotonin receptors, on plasma prolactin levels in lactating and ovariectomized rats.	the effect of methysergide (mes, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. mes caused significant increases in prolactin release in both animals. studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a decrease in the peripheral metabolism of prolactin. in vitro incubations of anterior pituitary fragments with mes failed to demonstrate any increase in prolactin release, suggesting ...	1975	126860
amino-acid sequence of the cyanogen-bromide fragment from human plasminogen that forms the linkage between the plasmin chains.	the complete amino acid sequence of a cyanogen bromide fragment (122 residues) obtained from plasminogen is described. this fragment forms the overlap between heavy (a) and light (b) chains of human plasmin. the particular arginyl-valyl bond cleaved in the second step of the activation process is shown to be arg98-val99 in this fragment. this site is not very similar to the one in the nh2-terminal part of the molecule (arg68-met69). remarkable homologies with the 'triple loops' ('kringle structu ...	1975	126863
elementary particles in isolated rat liver and spleen nuclear membranes.	elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ...	1975	126876
effects of various drugs on serum free and total tryptophan levels and brain tryptophan metabolism in rats.	various drugs known to bind to serum albumin were examined to determine whether or not they influenced the level of free tryptophan in serum in vitro and in vivo. possible relationships between the serum free tryptophan level and serotonin (5-ht) synthesis in the brain and the hypothermic effects of these drugs were investigated. of the drugs examined, sodium salicylate, sodium benzoate and indomethacin caused a significant increase in the concentration of serum free tryptophan and stimulated th ...	1975	127058
studies of substructure and tightly bound nucleotide in bacterial membrane atpase.	highly purified preparations of streptococcus faecalis atpase contain a similar but inactive protein detected by prolonged polyacrylamide gel electrophoresis. the inactive protein appears to arise by proteolytic cleavage of the major subunits in the enzyme. by use of a new technique, subunit analysis in sds gels was performed on the enzyme band and the inactive protein band excised from a polyacrylamide gel after electrophoresis. the results indicated that the atpase has the composition alpha3be ...	1975	127088
the significance of coronary arterial stenosis during cardiopulmonary bypass.	myocardial infarction may develop during an uneventful open-heart operation. in order to better understand this complication, we undertook an experimental study. the left circumflex coronary artery of 20 dogs was narrowed to 50 per cent of its area by a metal screw clamp to produce a localized coronary stenosis. regional myocardial perfusion in the distribution of both the stenotic circumflex and normal left anterior descending (lad) coronary arteries was measured by injection of a radioactive-l ...	1975	127092
role of mitochondrial calcium metabolism in the altered contractility of pressure-hypertrophied right ventricular myocardium.	pressure-hypertrophied right ventricular myocardium (rvh) demonstrates paradoxically increased oxygen consumption (mvo2) related to increase- in vitro energy-linked mitochondrial calcium flux. the present experiments were designed to measure mitochondrial ca retention in intact rvh and relate changes in mitochondrial ca metabolism to altered rvh contractility and relaxation. sixteen cats were pulmonary artery banded and their hearts plus paired controls were perfused with 45ca-labeled krebs-hens ...	1975	127354
[experiments and theoretical cell kinetic calculations on the problem of in vivo synchronization with vincristine in l 1210 ascites tumor cells and crypt cells of the mouse (author's transl)].	experiments are described on synchronizing l 1210 ascites tumor cells and jejunal crypt cells of the mouse with vincristine. in both cases the percentage of mitoses increases to a peak value 4 hrs after application of vincristine and decreases during the following 8 hrs ("releasing time") to the level of the normal mitotic index. following this first mitotic peak no futher peak of neither the mitotic nor the labeling index was observed during 48 hrs in l 1210 ascites tumor cells and during 38 hr ...	1975	127443
immunosuppressive activity of heterologous antimacrophage sera.	antisera against rat macrophages were raised in rabbits and tested individually, serologically and in vivo, by injecting 1.5 ml/100 g into lew rats 1 and 4 days following a graft of cdf rat skin. 1. erythrocyte absorption reduced the mean lymphocytotoxic titer of antimacrophage sera from 1:16 to 1:1, but yielded strongly immunosuppressive sera. they extended the graft survival time from the normal rate of 11-14 days up to 217 days. 2. additional absorption with lymphocytes reduced this activity ...	1975	127454
the postnatal development of the white pulp in the rat spleen and the onset of immunocompetence against a thymus-independent and a thymus-dependent antigen.	the spleen of the rat contains 5 well delineated compartments: a central and peripheral part of the periarteriolar lymphatic sheath (pals), the marginal zone and the follicle with centre and corona. a study was made on the development of these compartments in correlation with the onset of immunocompetence of the spleen. the spleens of animals in the age range from 1-40 days were studied with the light and electron microscopes. immunocompetence was assessed by measuring serum antibody levels 5 da ...	1975	127464
the cytotoxic activity of mouse t lymphocytes against allogeneic cytotoxic t cells.	using a 51cr cytotoxicity assay, the sensitivity of murine cytotoxic t cells to t cell mediated cytotoxicity has been tested. two experimental approaches have been used. first, cytotoxic t-blast-lymphocytes (ctbl), enriched by the velocity sedimentation at 1 g were used both as cytotoxic effector cells and as 51cr-labelled target cells. it was found that murine ctbl are capable to lyse directly and specifically allogeneic ctbl within 200 minutes. the second approach used was to incubate ctbl tog ...	1975	127466
reaction of yeast phosphofructokinase with succinic and maleic anhydride.	modification of yeast phosphofructokinase by succinic and maleic anhydride influences the catalytic activity and the allosteric behaviour of the enzyme. depending on the degree of succinylation and maleinylation a decrease of maximum activity, an increase of the apparent affinity for fructose-6-phosphate, a decrease of the hill-coefficient and a diminution of atp-inhibition are observed. up to about 40% of the lysyl residues could be succinylated without dissociation of the hexameric protein, ho ...	1975	127493
ampicillin resistant hemophilus influenzae meningitis in arkansas.		1975	127777
effect of essential phospholipids on the properties of atpases of isolated rat liver plasma membranes of young and old animals.	"essential" phospholipids (epl), rich in dilinoleyl-phosphatidylcholine were given orally to young and 780-800 day-old rats. the double-labelled (14c/32p) dilinoleyl-phosphatidylcholine was incorporated in plasma membranes and the amounts incorporated into different organs investigated. old animals incorporated higher radioactivity than young. the 14c/32p ratio however decreased in comparison with the substance administered. the amount of (na+-k+)-atpase in rat liver plasma membranes of old anim ...	1975	127894
monoaminergic mechanisms in aversive brain stimulation.	in these experiments we have examined the role of brain monoamines in the fearlike aversive responses produced by the electrical stimulation of the dorsal midbrain tegmentum (dmt). chronic bipolar stimulating electrodes were bilaterally implanted into the dmt of 77 rats. electrical stimulation via 34 of these electrodes produced fearlike, escape seeking responses. these animals were then trained for stable stimulus escape using a decremental bar pressing paradigm. in this paradigm, each bar pre ...	1975	128009
influence of age on orthostatic changes in plasma renin activity and urinary catecholamines in man.	the authors studied plasma renin activity (pra), urinary epinephrine, norepinephrine and dopamine excretion and their mutual relationships in 54 healthy subjects under basal (recumbent) conditions and age-related orthostatic changes in these parameters. the test subjects were divided into six 10-years groups, according to their year of birth (1901-1910 to 1951-1960). in the oldest groups (1901-1910 and 1911-1920), both basal pra values and norephrine and epinephrine excretion and their postural ...	1975	128010
the effect of constant light and chemical sympathectomy on the development of serotonin, n-acetyltransferase and monoamine oxidase activities in the rat epiphyses.	the daytime activity of n-acetyltransferase per mg epiphysis decreased to 1/10 the newborn level by the age of 13 days, and subsequently remained unchanged. the night activity was equal to the day activity at the age of 3 days, was higher at the age of 6 days and was 20 x that of the day level at the age of 40 days. keeping animals in constant light after birth depressed the development of these diurnal differences in n-acetyltransferase activity and slowed down the decrease in enzyme activity a ...	1975	128012
identification and actions of gastric inhibitory polypeptide.		1975	128084
[biology and classification position of chlamydia].		1975	128097
in vitro fertilisation of human oöcytes.	this paper describes attempts to cure infertility due to irremediable fallopian tube lesions by the laparoscopic recovery of pre-ovulatory ovarian oöcytes, their fertilisation in vitro, and their subsequent reimplantation into the uterine cavity.	1975	128140
inhibition of atp synthesis associated with 6-aminonicotinamide (6-an) teratogenesis in rat embryos.	pregnant rats were injected ip with 6 mg/kg 6-aminonicotinamide (6-an) at day 12 of gestation. embryos removed between 1 and 48 h later had reduced adenosine triphosphate (atp) concentrations, of about 50% of control values. all fetuses examined near term were malformed. nicotinamide (nam, 100 mg/kg) given ip 1 h after 6-an afforded protection: malformations occurred in only 15% of the survivors; and there was minimal atp reduction, 15% below control values. nam given 2 and 4 h after 6-an produc ...	1975	128147
normal and aberrant neuronal development in the cerebral cortex of human fetus and young infant.	several approaches utilized in ontogenetic investigations in laboratory animals have been explored in preliminary studies of morphogenetic events in the human cerebral cortex. 1. golgi studies of dendritic growth cones, filopodia, and other developmental processes have permitted specification of the maximal phase of dendritic growth and differentiation of pyramidal neurons in the hippocampus. this period spans the twentieth to twenty-eighth week of fetal development. 2. studies of the temporal p ...	1975	128168
[availability of mg2+, na+, and k+-atpase in the nuclei of the skeletal muscles of rabbits normally and during experimental muscular dystrophy].	a comparative study was carried out in the properties of atpase system of the skeletal muscle nuclei in the rabbits in norm and with experimental muscular dystrophy conditioned by e-avitaminosis. it is shown that in the system, containing 1.5 mm of mgcl2, atpase system of the nuclei is activated by sodium and potassium ions. in norm maximum activation is observed with their presence in the medium, the concentration being 80 and 70 mm, respectively. with experimental muscular dystrophy maximum a ...	1975	128169