Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [helicobacter pylori gastritis manifested by acute anemia]. | helicobacter pylori gastritis usually manifests as recurrent abdominal pain but is sometimes discovered upon evaluation for digestive tract bleeding with severe anemia. an 11-year-old who was not under medication and had no history of pain was admitted for isolated regenerative anemia (5.6 g/dl) due to digestive tract bleeding. laboratory tests showed only low serum iron and ferritin levels. endoscopy disclosed hemorrhagic inflammation of the duodenal cap and antritis with a hillocky appearance. ... | 1993 | 8352498 |
| [a study on the relationship between helicobacter pylori and chronic gastritis and peptic ulcer by the case-control method and sequential analysis]. | the association between helicobacter pylori and the chronic gastritis and peptic ulcer was investigated by the case-control method, 1:1 matched study and sequential analysis. the results of three methods showed that the degree of association between helicobacter pylori and the chronic gastritis and peptic ulcer was significant (chi 2 = 22.70, p < 0.001, or = 15.63, 95% ci of or was 5.05, 48.43), especially that between helicobacter pylori and active chronic gastritis (or = 20.92). the results in ... | 1993 | 8353820 |
| [helicobacter pylori infection and ulcer disease]. | 1993 | 8354141 | |
| detection of helicobacter pylori in gastric biopsy tissue by polymerase chain reaction. | to evaluate the sensitivity of a polymerase chain reaction (pcr) assay using nested primers in detecting helicobacter pylori, gastric tissue biopsy specimens were collected on endoscopy from 17 patients with a duodenal ulcer. dna was extracted by phenol/chloroform treatment or boiling in water, and then subjected to a nested pcr using two primer pairs from the urease gene of helicobacter pylori. fourteen of the 17 patients were positive for helicobacter pylori using dna samples extracted by eith ... | 1993 | 8354305 |
| kinetics of specific igg antibodies for monitoring the effect of anti-helicobacter pylori chemotherapy. | a total of 104 patients with recurrent duodenal ulcer were treated with either ranitidine plus amoxicillin plus metronidazole or ranitidine plus placebo. to study the effect of the eradication of helicobacter pylori on the systemic immune response in an igg elisa, sera were drawn from all patients before the onset of therapy and at 6, 16 +/- 2, 32 +/- 2, and 60 +/- 2 weeks after therapy. in patients with eradication of the organism, a significant (p < .001) reduction of the specific igg titer oc ... | 1993 | 8354918 |
| serologic response to helicobacter pylori among children and teenagers in northern chile. | the serologic response to helicobacter pylori was determined in 388 children and teenagers living in iquique, chile by using an igg enzyme-linked immunosorbent assay. serum antibody levels, as measured by optical density, correlated strongly with age. increases in the mean antibody level were seen primarily after age five, with rates of seropositivity increasing to > or = 70% among teenagers. the reasons for this age-related pattern of acquisition of infection remain to be determined. | 1993 | 8357081 |
| [barrett++ esophagus in children. presentation of 12 cases]. | this paper describes 12 cases of barrett's oesophagus selected out of a population of 364 refluxing children studied from 1986 to 1990. their mean age was 14, seven were cared for in special institutions for brain damaged and 2 had been operated upon for oesophageal atresia at birth. excessive acid exposure was documented in 8/10 patient studied and simultaneous gastric and oesophageal ph-monitoring demonstrated massive duodeno-gastric alkaline reflux in 3. histological studies revealed that col ... | 1993 | 8357725 |
| prevalence of helicobacter pylori infection in patients with precancerous changes and gastric cancer. | several papers suggested a role for h. pylori infection in gastric cancer. we evaluated the prevalence of h. pylori infection in an endoscopic population of patients with gastric precancerous conditions and lesions by studying biopsies from 252 patients and recording the presence and degree of h. pylori infection. patients were subgrouped as follows: chronic non-atrophic gastritis (cg), chronic atrophic gastritis (cag), intestinal metaplasia (im), epithelial dysplasia (ed) and gastric cancer (k) ... | 1993 | 8358284 |
| [the effect of omeprazole on healing of duodenal ulcers, helicobacter pylori and gastritis]. | losec (omeprazole) astra co. is a blocker of the proton pump of the parietal cell. it inhibits basal and stimulated hcl secretion. it is used for treatment of gastroduodenal ulcers, reflux oesophagitis and zollinger ellison's syndrome. in a group of 17 patients with duodenal ulcers the authors investigated the effect of omeprazole on (1) healing of duodenal ulcers and bulbitis after 2-4 weeks of therapy, (2) elimination of helicobacter pylori in the antrum, (3) chronic antral gastritis. ad 1. af ... | 1993 | 8358765 |
| one-day therapy for treatment of helicobacter pylori infection. | the present study evaluated the effect of a one-day high-dose combined therapy on helicobacter pylori infection. thirty-two consecutive patients (suffering from either peptic ulcer or nonulcer dyspepsia) with helicobacter pylori infection received omeprazole (40 mg) + bismuth subcitrate (240 mg x 4) + amoxicillin suspension (2000 mg x 4) + metronidazole (500 mg x 4), for only one day. endoscopy, histology, culture, and susceptibility studies were done at entry and 30 and 90 days after the treatm ... | 1993 | 8359079 |
| bismuth subsalicylate suppression of helicobacter pylori in nonulcer dyspepsia: a double-blind placebo-controlled trial. | gastritis caused by helicobacter pylori (hp) is common in patients with nonulcer dyspepsia (nud), but an etiologic relationship between the histologic lesion and clinical symptoms is unproven. hp is inhibited by bismuth subsalicylate (bss), a traditional remedy for dyspeptic complaints. the aim of this study was to assess the short- and long-term effects of bss on hp, gastritis, and symptoms in patients with nud. one hundred twenty-six patients with nud who were shown to be infected with h. pylo ... | 1993 | 8359080 |
| helicobacter pylori infection, abo blood group, and effect of misoprostol on gastroduodenal mucosa in nsaid-treated patients with rheumatoid arthritis. | our aim was to investigate the effect of misoprostol on nsaid-induced gastroduodenal mucosal damage in patients with rheumatoid arthritis. the study included 40 patients, and it was designed as a double-blind, placebo-controlled trial. misoprostol significantly reduced the gastroduodenal mucosal lesions found at endoscopy (p < 0.05) and prevented the development of ulcers. the cumulative incidence of ulcers at four weeks was 5% in the placebo group and 0% in the misoprostol group. the basal and ... | 1993 | 8359082 |
| production of chemoattractant by helicobacter pylori. | helicobacter pylori is present in the antral region of the stomach in a majority of patients with gastritis type b. the specific mechanism whereby the organism participates in the development of disease remains uncertain. since the organism is not invasive, we postulate that h. pylori produces a chemoattractant that recruits inflammatory cells to the antral region of the stomach. h. pylori was grown under microaerophilic conditions at 37 degrees c for 72 hr in brucella broth containing 1% fetal ... | 1993 | 8359083 |
| congestive gastropathy versus chronic gastritis: a comparison of some pathophysiological aspects. | in order to investigate some pathophysiological aspects of the two diseases, 15 patients with congestive gastropathy and 15 with chronic gastritis have been studied and compared with 15 healthy controls. gastric blood flow as determined during endoscopy by means of laser doppler flowmetry was found to be significantly increased (p < 0.001) in congestive gastropathy, whereas a significant reduction (p < 0.001) was noted in chronic gastritis. on the other hand, helicobacter pylori was detected in ... | 1993 | 8359558 |
| epidemiology and genetics of peptic ulcer. | at the turn of the century, duodenal ulcer rose from rarity to affect 10% of males in their life time, subsequently declining in some countries such as uk, levelling off in others such as germany, and continuing to increase in still others such as hong kong. the annual incidence per 1000 population varies from about 1 in japan to 1.5 in norway, 1.8 in usa and 2.7 in scotland, and the frequency also varies within many individual countries, such as australia, china and india, and among races such ... | 1993 | 8359624 |
| the role of helicobacter pylori in peptic ulcer disease. | the linking of relapse of duodenal as well as gastric ulcers with helicobacter pylori (h. pylori) has been a considerable advance in managing patients with peptic ulcer disease. however, pathogenetic role of h. pylori in peptic ulcer still remains unclear. the aim of this study was to assess the relationship between h. pylori infection and inflammatory cell infiltration in gastric mucosa in peptic ulcer disease. sixty-four patients with endoscopically proven gastric ulcer and 26 patients with du ... | 1993 | 8359625 |
| an immunofluorescent stain for helicobacter pylori. | we prepared a murine monoclonal antibody that recognized the helicobacter pylori urease. monoclonal antibody, u2, reacted with purified native urease in enzyme linked immunosorbent assay but it did not react in western immunoblot analysis. urease was immunoprecipitated with u2 bound to staphylococcus aureus protein a, followed by elution and visualization by sodium dodecyl-sulfate polyacrylamide gel electrophoresis. the species and strain specificity of u2 were determined by biodot reaction with ... | 1993 | 8359826 |
| [the role of helicobacter pylori in the etiology of peptic ulcer and its therapy]. | the isolation of helicobacter pylori from human gastric mucosa by warren and marshall in 1984, has given new approaches in etiology of peptic ulceration. approximately all of duodenal ulcer patients have displayed antral gastritis with helicobacter pylori, made strong suspicion of the bacteria in the etiology of duodenal ulcer. in therapy, combination of antibiotics to acid suppressive therapy should be preferred to antibiotics only. | 1993 | 8361417 |
| the role of helicobacter pylori in peptic ulcer disease. | the pathophysiology of peptic ulcer disease (pud) is often described as an imbalance between aggressive factors such as acid and pepsin and alterations in the mucosal protective mechanisms. helicobacter pylori is a gram-negative organism that has been identified as a potential causative agent in the pathogenesis of pud. the exact mechanism by which it contributes to mucosal damage is unknown. it is thought that the organism may disrupt the protective mucous layer, allowing the underlying epithel ... | 1993 | 8361859 |
| helicobacter pylori and peptic ulcer disease. reexamining the therapeutic approach. | now that helicobacter pylori has been strongly implicated as a causative factor in peptic ulcer disease, the dictum "no acid--no ulcer" may no longer be valid. however, h pylori has proved difficult to eradicate, and the approach to treatment of peptic ulcer is undergoing changes. at present, a triple-drug combination of bismuth and antibiotics is advised, and cultures should be obtained before and after treatment to monitor its efficacy. side effects include pseudomembranous colitis and drug re ... | 1993 | 8361941 |
| helicobacter pylori infection in peptic ulcer disease. | 1993 | 8362207 | |
| long-term helicobacter pylori recurrence after successful eradication with triple therapy. | to establish the rate of helicobacter pylori recurrence after a standard triple-therapy regimen (bismuth subsalicylate, tetracycline, metronidazole) and determine which clinical factors affect reinfection, we prospectively followed 118 patients after successful h. pylori eradication. elimination of h. pylori was confirmed by repeat endoscopy and urea breath test 4 wk after completion of therapy. serial [13c]urea breath tests were performed at 3-month intervals; antral biopsies were used to verif ... | 1993 | 8362830 |
| gastric mucosal hydrophobicity and helicobacter pylori: response to antimicrobial therapy. | the hydrophobic properties of the gastric mucosa are reduced by nsaids and by helicobacter pylori infection. our investigation was to determine whether this abnormality was due to the bacteria or to the inflammatory response. contact angle measurements were made on gastric antral and corpus biopsies taken from 10 h. pylori-infected volunteers before eradication therapy, after 2 and 14 days of therapy, and 4 weeks after therapy. the contact angle improved steadily and statistically throughout the ... | 1993 | 8362831 |
| evaluation of new therapy for eradication of h. pylori infection in nude mouse model. | developing a new therapy for eradication of h. pylori by using the nude mouse model. | 1993 | 8362832 |
| helicobacter pylori and intestinal metaplasia: comparison between british and yemeni patients. | there have been suggestions linking gastric carcinoma with helicobacter pylori on the one hand and type iii intestinal metaplasia on the other hand. this study was aimed at investigating the relationship between intestinal metaplasia and its subtypes, and the presence or absence of h. pylori in gastric biopsies from two geographically different patient populations, one with a much higher prevalence of h. pylori than the other. antral biopsies from 179 british and 123 yemeni patients with dyspeps ... | 1993 | 8362833 |
| local gastric and serum amoxicillin concentrations after different oral application forms. | the high recolonization rate after monotherapy of helicobacter pylori-positive gastritis may be due to insufficient local drug concentrations. to investigate the role of local diffusion, we measured levels of amoxicillin, a drug with good in vitro activity against h. pylori, in the mucosa and serum. one gram of amoxicillin was given to healthy volunteers as a tablet (n = 6) or as water-dissolved, fizzing "tab" (n = 6). gastroscopy with biopsies from the antrum, corpus, and fundus was performed a ... | 1993 | 8363383 |
| helicobacter pylori infection in an hiv-seropositive patient with diarrhoea. | 1993 | 8363772 | |
| gastric anti-secretory, mucosal protective, anti-pepsin and anti-helicobacter properties of ranitidine bismuth citrate. | ranitidine bismuth citrate is a novel compound formed from ranitidine and a bismuth citrate complex. in conscious dogs, ranitidine bismuth citrate had similar activity to ranitidine hydrochloride as an inhibitor of histamine-induced gastric acid secretion when oral doses containing equivalent amounts of ranitidine base (0.1 or 0.3 mg/kg) were compared. in the rat, ranitidine bismuth citrate (3-30 mg/kg p.o.) prevented gastric mucosal damage induced by ethanol (fundic damage) and indomethacin (an ... | 1993 | 8364129 |
| short report: high-dose omeprazole and amoxycillin in the treatment of helicobacter pylori-associated duodenal ulcer. | thirteen consecutive patients with active duodenal ulcer disease were assigned to a treatment schedule with high-dose omeprazole and amoxycillin. duodenal ulcer was diagnosed endoscopically in all patients, at which time antral biopsies were taken for culture and histology. all were positive for helicobacter pylori and histological gastritis. treatment was for 2 weeks: 80 mg omeprazole daily plus 500 mg amoxycillin syrup t.d.s. in the first week, followed by 40 mg omeprazole daily in the second ... | 1993 | 8364136 |
| the need for long-term treatment of peptic ulcer. | some 10% of the population in western countries will suffer a duodenal ulcer or gastric ulcer at some time in their lives. although there has been an improvement in the survival rate of patients with peptic ulcer haemorrhage, the mortality is still approximately 10%. there is evidence to suggest that peptic ulcer disease is a life-long condition and that ulcers remain active with an unchanged potential for complications such as haemorrhage and perforation. over the past 15 years anti-ulcer drugs ... | 1993 | 8364141 |
| high-affinity binding of laminin by helicobacter pylori: evidence for a lectin-like interaction. | laminin, the major glycoprotein of basement membranes, was shown to be bound by the human gastric pathogen helicobacter pylori. binding of 125i-laminin by strain 17874 was time-dependent, specific and saturable. scatchard analysis of specific binding indicated about 2000 binding sites per cell with a dissociation constant of 8.5 pm. treatment of the cells by heat (80 degrees) and with proteolytic enzymes drastically reduced laminin binding, suggesting that the laminin receptors are surface prote ... | 1993 | 8364520 |
| colloidal bismuth subcitrate, ranitidine, and ranitidine plus metronidazole in the treatment of duodenal ulcer and helicobacter pylori infection: a controlled and prospective study. | a controlled, prospective clinical trial of colloidal bismuth subcitrate (cbs), ranitidine and ranitidine plus metronidazole for the treatment of duodenal ulcer (du) is reported here, with evaluation of the possible pathogenic role of helicobacter pylori (hp) on du in a six-month follow-up. a total of 42 patients with active du on endoscopy were randomly selected to receive oral cbs (300 mg 1 hour before each meal, and at bedtime, n = 16), ranitidine (150 mg bid; n = 12) or ranitidine (150mg b.i ... | 1993 | 8364776 |
| the association of helicobacter pylori with differentiated-type early gastric cancer. | recent studies have indicated that infection with helicobacter pylori is closely associated with increased risk for gastric cancer. previous studies, however, usually have been made on cases of advanced gastric cancer. | 1993 | 8364862 |
| granulomatous gastritis: a morphological and diagnostic approach. | the final diagnosis of granulomatous gastritis is based on morphological findings and clinical and laboratory data. detailed analysis of the morphological features of the granulomas together with associated mucosal changes could generate more information on aetiology and pathogenesis. biopsies from 71 patients diagnosed as having granulomatous gastritis were reviewed. thirty-seven of these patients (52%) had crohn's disease. in 18 patients (25%) an isolated granulomatous gastritis was diagnosed. ... | 1993 | 8365714 |
| [natural history of duodenal ulcer]. | the authors have studied the natural history of duodenal ulcer from published data, in an attempt to determine precisely the evolutive potential of this disease both spontaneously and during its treatment. they deal successively with the risk of complication and the short- or long-term influence of medical and surgical treatment on the occurrence of exacerbations and complications. the role played by helicobacter pylori in healing of the ulcer and in the long-term course of the ulcerous disease, ... | 1993 | 8367419 |
| [serologic detection of helicobacter pylori antibodies after surgery for stomach and duodenal ulcer]. | the occurrence of igg antibodies to helicobacter pylori was measured by means of elisa in 175 patients who had undergone surgery for duodenal or gastric ulcer. there was a significant correlation between surgery with resection and the absence of igg to helicobacter pylori in about 80% of cases. in patients undergoing surgery without resection there was no influence of the surgical technique on the presence of helicobacter pylori antibodies. | 1993 | 8367977 |
| biochemical and histopathological aspects in duodenogastric reflux gastritis patients with or without prior cholecystectomy. | the aim of this study was to evaluate some biochemical and histopathological aspects in a group of patients with a view to identifying any differences depending on whether the pathology was associated with previous cholecystectomy or idiopathic. the study involved 23 patients (8 post-cholecystectomy cases and 15 ulcer-free dyspeptic patients) with the diagnosis of duodenogastric reflux gastritis confirmed by endoscopic histopathological evaluation. the following parameters were considered: 1. ph ... | 1993 | 8368047 |
| [colloidal bismuth subcitrate and amoxicillin in the treatment of helicobacter pylori infection in children]. | we have analyzed the effect of treatment with colloidal bismuth subcitrate (cbs) and amoxicillin in a series of 60 children (age range: 2.9-18 years) infected by helicobacter pylori (hp). the following results were found: clinical remission 70%; endoscopic normalization 55%; histological normalization 61.6% and hp eradication 53.3%. the improvement of histological activity (100% vs 11.7%) and histological normalization (90.6% vs 28.5%) were significantly more frequent in the hp eradicated group ... | 1993 | 8368681 |
| metronidazole susceptibility testing for helicobacter pylori: comparison of disk, broth, and agar dilution methods and their clinical relevance. | since the methods for metronidazole susceptibility testing of helicobacter pylori have not been standardized or validated, we compared three methods that are used to test the metronidazole susceptibilities of 25 isolates of h. pylori. specifically, we examined the methods of steer's replicator agar dilution, tube broth microdilution, and modified kirby-bauer disk diffusion. the metronidazole disk zone sizes obtained by the disk diffusion method correlated well (r = 0.74) with the mics obtained b ... | 1993 | 8370723 |
| a highly specific and sensitive dna probe derived from chromosomal dna of helicobacter pylori is useful for typing h. pylori isolates. | hindiii-digested dna fragments derived from an ecori-digested 6.5-kb fragment of chromosomal dna prepared from helicobacter pylori atcc 43629 (type strain) were cloned into the puc19 vector. a 0.86-kb insert was identified as a potential chromosomal dna probe. the specificity of the probe was evaluated by testing 166 non-h. pylori bacterial strains representing 38 genera and 91 species which included aerobic, anaerobic, and microaerophilic flora of the upper and lower gastrointestinal tracts. no ... | 1993 | 8370744 |
| detection of immunoglobulin g antibodies to helicobacter pylori in urine by an enzyme immunoassay method. | urine and serum samples from 306 patients undergoing upper endoscopy were evaluated prospectively to determine the presence of immunoglobulin g (igg) antibodies to helicobacter pylori by an enzyme immunoassay method. forty-nine selected urine specimens were also tested by western blotting (immunoblotting). when compared with bioptic methods (culture, stain, urease testing), the sensitivity and specificity of the assay for urine igg to h. pylori were 95.9 and 90%, respectively. results of testing ... | 1993 | 8370747 |
| susceptibility of helicobacter pylori and pharmacokinetic properties in mice of new 5-nitroimidazole derivatives devoid of mutagenic activity in the ames test. | the minimum inhibitory concentrations of metronidazole and four new 5-nitroimidazole derivatives (eu 11100, eu 11102, eu 11103, eu 11104), obtained by the reaction of 1-methyl-5-nitroimidazolyl-2-carboxyaldehyde and terbutyl-phenol, were determined against 25 clinical isolates of helicobacter pylori. three of them (eu 11100, eu 11103, eu 11104) exhibited an antibacterial activity higher than that of metronidazole. the last one, the molecule eu 11102, was less active than metronidazole. in mice, ... | 1993 | 8371126 |
| [costs and effectiveness of diagnosis and treatment of patients with dyspepsia, determined with the aid of a computer model]. | a theoretical investigation was carried out to determine whether the use of an antibody test for helicobacter pylori (hp) and the use of bismuth oxide with optional antibiotics, would be cost effective in the diagnosis and treatment of patients with dyspepsia. with literature data on therapeutic effectiveness a computer simulation was carried out. a quick antibody test reduced the number of gastroscopic investigations necessary. gastroscopic investigation still had to be carried out for patients ... | 1993 | 8371821 |
| [ranitidine therapeutically effective in functional dyspepsia with reflux-like symptoms]. | to investigate the effect of ranitidine in patients with functional dyspepsia according to different subgroups. | 1993 | 8371822 |
| fluorinated probes to measure carboxylesterase activities using 19f nmr spectroscopy: application to erythrocytes and helicobacter pylori. | eight fluorinated compounds were tested as putative probes to measure carboxylesterase activity employing 19f nuclear magnetic resonance spectroscopy. the method takes advantage of the sensitivity of fluorine resonances to the changes in the chemical bonding in the covalent structures where they are located. determination of the kinetic parameters of ethyl fluoroacetate and diethyl fluoromalonate in hemolysates showed that these probes were well suited to study carboxylesterase activities in com ... | 1993 | 8373162 |
| [the clinico-endoscopic characteristics of gastric erosions and their relationship to helicobacter pylori lesions]. | fibrogastroduodenoscopy was carried out in 285 patients. in all cases with gastric erosions chromograstroscopy was done with the purpose of revealing the acid-production function of the stomach. helicobacter pylori was revealed mainly in patients with "complete" erosions against the background of chronic gastritis b. | 1993 | 8379140 |
| use of serum specific immunoglobulin antibodies to determine helicobacter pylori associated gastritis. | a prospective study in 169 consecutive patients referred for upper gastrointestinal endoscopy was initiated to investigate the diagnostic performance of serum helicobacter pylori (hp) specific immunoglobulin (ig) g antibodies. using an enzyme linked immunosorbent assay (elisa) an excellent correlation between serologic evidence of hp and the demonstration of this organism by histology and urease test in 79 hp-positive patients was found. serum igg also correlated with the histological degree and ... | 1993 | 8379229 |
| [prevalence of helicobacter pylori and gastritis in southern germany. results of a representative cross-sectional study]. | the recent discussions about the relationship between helicobacter-pylori-infection, gastritis and the occurrence of stomach cancer caused us to analyse blood sera of 543 participants randomly selected from the general population in the age of 25 to 34 and of 55 to 64 years from mosbach (neckar-odenwald-kreis), the county of deggendorf (lower-bavaria) and augsburg (upper-bavaria) regarding igg-antibodies against helicobacter pylori and the concentrations of the pepsinogens a and c. the latter we ... | 1993 | 8379230 |
| [qualitative and semiquantitative invasive and noninvasive diagnosis of helicobacter pylori colonization of gastric mucosa]. | in 110 patients with unknown helicobacter pylori status and without anti-bacterial treatment submitted for routine endoscopy of the upper gastrointestinal tract biopsies were taken from the antral and body mucosa, which were assessed for h. pylori colonisation and/or gastritis by an urease test (jatrox h. p.-test), microscopy after methylene-blue staining of a mucosal smear, specific culture and histology (stains: haematoxylin & eosin and warthin-starry). in addition, a simplified 13c-urea breat ... | 1993 | 8379231 |
| [clinico-pharmacologic considerations in helicobacter pylori eradication therapy]. | problems and pitfalls of treatment regimens for eradication of helicobacter pylori (hp) are discussed from a clinical, pharmacological and microbiological point of view. problems concerning the physician who treats the patient consists mainly in inappropriate indication and suboptimal knowledge of drugs, doses and duration of therapy against hp. for successful triple therapy with complicated dosage protocols cooperation with and compliance by the patient is stressed. physicochemical, pharmacolog ... | 1993 | 8379234 |
| [therapy of helicobacter pylori infection: current status]. | h. pylori is closely associated with gastritis, peptic ulcer disease and gastric cancer. a causative role of h. pylori is now established in type b gastritis, its role in non ulcer dyspepsia is unresolved. eradication of h. pylori results in a marked decrease of peptic ulcer relapse rates. gastric cancer risk is 2- to 8-fold increased if gastric mucosa is colonized by h. pylori. treatment of h. pylori infection is difficult although the organism is highly sensitive to several antibiotics in vitr ... | 1993 | 8379235 |
| prevalence of helicobacter pylori in brazilian patients with gastric carcinoma. | investigators have speculated on the role of helicobacter pylori in gastric carcinogenesis. the current study was performed to evaluate prospectively the prevalence of h. pylori infection in the stomachs of brazilian patients with gastric carcinoma. forty patients receiving gastrectomy for gastric carcinoma were studied. h. pylori was examined in four areas without atrophy or with minor atrophic changes. mucosal fragments were obtained for microbiologic studies in 19 cases. h. pylori was detecte ... | 1993 | 8379532 |
| helicobacter acinonyx sp. nov., isolated from cheetahs with gastritis. | four strains of a novel helicobacter species were isolated from the stomachs of cheetahs (acinonyx jubilatus) with gastritis. these isolates were phenotypically similar to helicobacter pylori. the isolates were gram-negative, spiral bacteria which grew under microaerophilic conditions at 37 degrees c, but not at 25 or 42 degrees c, and produced urease, catalase, oxidase, alkaline phosphatase, and gamma-glutamyl transpeptidase. the isolates did not ferment glucose, mannitol, inositol, sorbitol, r ... | 1993 | 8379970 |
| role of gastric ph in isolation of helicobacter mustelae from the feces of ferrets. | helicobacter mustelae colonizes the gastric mucosa of ferrets and causes persistent chronic gastritis. | 1993 | 8380398 |
| comparison of helicobacter pylori and attaching-effacing escherichia coli adhesion to eukaryotic cells. | adhesion of helicobacter pylori was reported previously to be morphologically identical to "attaching and effacing" escherichia coli. therefore, the aim of the present study was to define the adhesion phenotype of h. pylori lc-11 to hep-2, kato-iii, hel, and cho tissue culture cells. by using both staining of f-actin with fluorescein-labeled phalloidin and ultrastructural analysis, diffuse bacterial adhesion to discrete microvillus-denuded regions of the plasma membrane was observed in each of t ... | 1993 | 8380793 |
| an in vitro adherence assay reveals that helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. | helicobacter pylori is a microaerophilic bacterium found in the stomach of asymptomatic humans as well as patients with acid peptic disease and gastric adenocarcinoma. we have developed an in situ adherence assay to examine the cell lineage-specific nature of binding of this organism and to characterize the nature of cell surface receptors that recognize its adhesin. fluorescein isothiocyanate-labeled h. pylori strains were bound to surface mucous cells present in the pit region of human and rat ... | 1993 | 8383333 |
| effect of ph variation on the susceptibility of helicobacter pylori to three macrolide antimicrobial agents and temafloxacin. | the in vitro susceptibility of 27 clinical isolates of helicobacter pylori to erythromycin, clarithromycin, azithromycin and temafloxacin under various ph conditions was evaluated. clarithromycin (mic90 0.03 micrograms/ml) was found to be significantly more active than either erythromycin (mic90 0.125 micrograms/ml) or azithromycin (mic90 0.25 micrograms/ml) at a neutral ph. lowering the ph to 5.75 resulted in a loss in efficacy from 8- to 32-fold for all three macrolides studied. the mic90 of c ... | 1993 | 8388791 |
| prevalence of helicobacter pylori in patients with chronic renal failure. | the prevalence of helicobacter pylori (h. pylori) was investigated in 164 consecutive patients with different degrees of renal function; group i (normal renal function) n = 84, group ii (chronic renal failure, clcr > or = 5 < 90 ml/min) n = 45, group iii (haemodialysis therapy) n = 35, to test the hypothesis that the resulting different concentrations of urea in the gastric juice would have an influence on the colonization of the gastric mucosa by these urea-splitting bacteria. as every individu ... | 1993 | 8390002 |
| enhanced gastric mucosal leukotriene b4 synthesis in patients taking non-steroidal anti-inflammatory drugs. | the effects of longstanding non-steroidal anti-inflammatory drug (nsaid) treatment on gastric mucosal synthesis of leukotriene b4 (ltb4), leukotriene c4 (ltc4), and prostaglandin e2 (pge2) was studied. gastric antral biopsies in 65 patients with arthritis taking nsaids and 23 control patients were taken and eicosanoid concentrations, stimulated by vortex mixing or calcium ionophore, were measured by radioimmunoassay. median gastric mucosal synthesis of ltb4 was increased in patients taking nsaid ... | 1993 | 8390958 |
| studies on the mechanism of action of colloidal bismuth subcitrate. i. interaction with sulfhydryls. | the present study was designed to examine the reaction pathway of colloidal bismuth subcitrate (cbs) with thiols. studies were performed using the monothiol glutathione (gsh), the dithiol dithiothreitol (dtt) and the thiol enzymes papain and h+/k(+)-atpase. uv-vis spectra showed that cbs forms complexes with gsh and dtt. the gsh/cbs complex but not the dtt/cbs complex was cleared by 5,5'-dithiobis-(2-nitrobenzoic acid). cbs inhibited h+/k(+)-atpase (ic50: 23 +/- 6.5 mumol/l) but failed to inhibi ... | 1993 | 8395060 |
| [comparison of acid and helicobacter pylori in ulcerogenesis of duodenal ulcer disease]. | to test the efficacy of short-term ranitidine and antibacterial drugs in patients with h. pylori associated duodenal ulcer disease and to compare the importance of acid and h. pylori in ulcerogenesis, 90 outpatients were randomly assigned to one of five regimens: ranitidine, 150 mg in the morning and at bedtime; gentamicin, 40 mg tid; terramycin, 500 mg tid; furazolidone, 100 mg tid; or berberine, 300 mg tid. the patients were evaluated endoscopically, microbiologically and histologically before ... | 1993 | 8395315 |
| [helicobacter pylori and hiv infection]. | 1993 | 8399480 | |
| evaluation of new antiinfective drugs for helicobacter pylori infection: revisited and updated. | 1993 | 8399892 | |
| effect of helicobacter pylori colonization on quantitative distribution of antral g-cells in apparently healthy subjects and in duodenal ulcer patients. a morphometric study. | to investigate whether antral colonization by helicobacter pylori (hp) modifies gastrin-cell population, the number of g-cells was evaluated in antral biopsy specimens from 22 apparently healthy subjects and from 48 duodenal ulcer patients using a morphometric method. the level of serum immunoreactive gastrin in a sample of fasting serum obtained at the time of biopsy was also measured. in healthy subjects the g-cell count (evaluated according to g/i index) and the serum gastrin levels were not ... | 1993 | 8400368 |
| the relationship between helicobacter pylori and oxygen-derived free radicals in the mechanism of duodenal ulceration. | this prospective randomized study investigated the possibility that duodenal ulcer relapse associated with helicobacter pylori infection is mediated by oxygen-derived free radicals. to this end, the radical scavengers allopurinol (50 mg 4 times daily) and dimethyl sulphoxide (dmso, 500 mg 4 times daily) were administered orally. one hundred and forty-six consecutive patients with previous symptomatic endoscopy proven duodenal ulceration, which had been shown endoscopically to have healed in the ... | 1993 | 8400493 |
| anti-helicobacter pylori antibodies prevalence and gastric adenocarcinoma in portugal: report of a case-control study. | evidence from large cohort studies has established an increased risk of gastric cancer for individuals infected with helicobacter pylori (hp). in low incidence countries, like the united kingdom and sweden, case-control studies suggested that the prevalence of anti-hp antibodies in gastric cancer patients (at the time of cancer diagnosis) is greater than in control populations. we present results from a case-control study of the prevalence of igg anti-hp antibodies in gastric cancer patients and ... | 1993 | 8401171 |
| gastric cancer and helicobacter pylori infection. | 1993 | 8402077 | |
| mnng-induced gastric carcinoma in ferrets infected with helicobacter mustelae. | n-methyl-n-nitro-n'-nitrosoguanidine (mnng) is a gastric carcinogen in several animal species and has been used in a number of systems to dissect the co-carcinogenic potential of various compounds in the induction of gastric adenocarcinoma. recent epidemiological evidence suggests that helicobacter pylori may play a role as a co-carcinogen in the etiology of this tumor in humans and we have been interested in developing an animal model to study this possibility. a related organism, h. mustelae, ... | 1993 | 8403224 |
| [the diagnostic accuracy of gastric urease activity for helicobacter pylori]. | the diagnostic accuracy of gastric urease activity for helicobacter pylori (hp) infection were studied in 98 patients with peptic ulcer, gastritis and chronic renal failure. gastric aspirates were analyzed for urea nitrogen and ammonia. urease activity was calculated as the ratio of gastric ammonia to sum of gastric urea nitrogen and ammonia. gold standard assessments to hp infection were rapid urease test, histology and/or culture. the results showed that the values of urease activity in patien ... | 1993 | 8404318 |
| are routine cleaning methods sufficient to remove helicobacter pylori from endoscopic equipment? | 1993 | 8404717 | |
| transmission of helicobacter pylori by endoscopy? | 1993 | 8404718 | |
| helicobacter pylori and intestinal metaplasia: possible implications in gastric carcinogenesis. | 1993 | 8404719 | |
| in vitro susceptibility of helicobacter pylori to trospectomycin, pirlimycin (u-57930e), mirincamycin (u-24729a) and n-demethyl clindamycin (u-26767a). | the in vitro activity of trospectomycin, pirlimycin, mirincamycin and n-demethyl clindamycin was measured against 46 clinical isolates of helicobacter pylori using an agar dilution technique. the mic50 and mic90 were 4 and 64 micrograms/ml for pirlimycin and n-demethyl clindamycin, and 32 and 128 micrograms/ml for mirincamycin, respectively. all 46 strains were sensitive to trospectomycin with an mic50 of 8 micrograms/ml and an mic90 of 16 micrograms/ml. of seven strains with the highest trospec ... | 1993 | 8404921 |
| accuracy of a rapid 10-minute carbon-14 urea breath test for the diagnosis of helicobacter pylori-associated peptic ulcer disease. | urease in the human gastric mucosa is a marker for infection with helicobacter pylori (hp), an organism which is associated with peptic ulcer disease. to detect gastric urease, we examined 184 patients (144 males, 40 females; mean age: 49.8 +/- 15.6 years) with suspected peptic ulcer disease. fasting patients were given orally 5 microci of carbon-14 labelled urea. from each patient only one breath sample was collected in hyamine at 10 min. the amount of 14c collected at 10 min was expressed as f ... | 1993 | 8404959 |
| comparisons between degree of histological gastritis and dna fingerprints, cytotoxicity and adhesivity of helicobacter pylori from different gastric sites. | thirty-six isolates of h. pylori from up to three gastric biopsy sites (antrum, corpus and fundus) from 13 patients in italy with different degrees of histological gastritis were investigated. all strains were tested for motility, cytotoxicity and degree of adhesion, and were typed by analysis of ribosomal rna gene patterns (ribopatterns). seventeen different dna types (ribotypes) were identified, with each patient possessing h. pylori of one or more unique types. only two patients had identical ... | 1993 | 8405318 |
| helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. | helicobacter pylori has been implicated as a possible etiologic factor in gastric cancer. this case control study was performed to determine the association between h. pylori and gastric cancer, taking into account the possibility of confounding by other background factors. | 1993 | 8405854 |
| duodenal histology, ulceration, and helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs. | duodenitis and gastric metaplasia, which is often colonised by helicobacter pylori (h pylori), are increasingly recognised for their importance in the pathogenesis of duodenal ulcers. the situation is not clear in patients receiving non-steroidal anti-inflammatory drugs (nsaids), who have a higher risk of peptic ulceration. the aim of this study was to identify the duodenal histological abnormalities in the presence or absence of nsaids, h pylori, and duodenal ulceration. endoscopic duodenal bio ... | 1993 | 8406146 |
| amoxicillin plus omeprazole versus triple therapy for eradication of helicobacter pylori in duodenal ulcer disease: a prospective, randomized, and controlled study. | treatment with amoxicillin and omeprazole resulted in encouraging helicobacter pylori eradication rates in pilot studies that included medium term follow up. these results were evaluated in a prospective, randomised and controlled study. forty patients with active duodenal ulcer disease and h pylori colonisation of the gastric mucosa were randomly assigned to receive either omeprazole (20 mg twice daily) and amoxicillin suspension (500 mg four times daily) for two weeks (group i) or bismuth subs ... | 1993 | 8406147 |
| gastric adenocarcinoma with ciliated tumor cells. | ciliated metaplasia (cm) of gastric mucosa is common in japanese individuals but rare in whites. we studied 36 consecutive gastrectomies from chinese individuals for the presence of cm. the gastrectomies were performed for adenocarcinoma (n = 22), benign ulcer (n = 13), and malignant lymphoma (n = 1). ciliated metaplasia was found in 16 (44.4%) of the stomachs, with equal distribution between male and female patients. ciliated metaplasia was present in 11 cases (50%) of adenocarcinoma and in fiv ... | 1993 | 8406420 |
| adherence of helicobacter pylori to primary human gastrointestinal cells. | helicobacter pylori adheres only to gastric cells in vivo. however, the organism adheres to a wide variety of nongastric cells in vitro. in this study, we have used flow cytometry to assess the adherence of h. pylori to primary epithelial cells isolated from gastric, duodenal, and colonic biopsy specimens by collagenase digestion. after incubation of bacteria and cells together and subsequent staining with a two-stage fluorescein isothiocyanate-labelled h. pylori antibody method, cells with adhe ... | 1993 | 8406792 |
| helicobacter pylori infection. | the discovery of helicobacter pylori is arguably the most significant advance made in gastroduodenal pathology this century. it is the most important cause of chronic gastritis, and almost certainly the major aetiological factor responsible for duodenal ulcer and probably for gastric ulcer as well. evidence is accumulating which suggests that it may play an important role in the pathogenesis of gastric cancer. h. pylori is thought to be transmitted by the faecal-oral route or possibly oral-oral ... | 1993 | 8407699 |
| enhanced cultivation of helicobacter pylori in liquid media. | to evaluate a technique for culture of helicobacter pylori in large quantities of liquid media and to determine the factors that could influence the results. | 1993 | 8408702 |
| distribution of helicobacter pylori colonisation and associated gastric inflammatory changes: difference between patients with duodenal and gastric ulcers. | to determine the gastric distribution of helicobacter pylori in patients with duodenal and gastric ulcers; and to examine the mucosal inflammatory response. | 1993 | 8408703 |
| are routine duodenal and antral biopsies useful in the management of "functional" dyspepsia? a diagnostic and therapeutic study. | fifty-three patients with previously uninvestigated chronic dyspepsia symptoms in the absence of gastrointestinal or extra-gastrointestinal disease (functional dyspepsia) underwent antral and duodenal mucosal biopsies to detect the role of such samplings in the presence of normal endoscopic findings. patients were enrolled in a randomized, placebo-controlled, double-blind trial, receiving either eradicating treatment (colloidal bismuth subcitrate plus metronidazole) or placebo if they had helico ... | 1993 | 8409311 |
| endoscopy-negative dyspepsia. hold those forceps! | nonulcer dyspepsia (nud) is an enigmatic disorder which likely has heterogeneous etiologies. helicobacter pylori-associated gastritis has been identified in a large number of patients with nud, raising speculation that chronic infection with this organism may cause dyspepsia in some patients. prospective case-control and cohort studies however do not suggest that h. pylori prevalence is greater in nud than in asymptomatic controls. limited therapeutic trials of h. pylori-eradication therapy have ... | 1993 | 8409329 |
| [cytotoxic effect of ammonia produced by helicobacter pylori urease on the cultural cells]. | we investigated the action of the ammonia produced by helicobacter pylori urease on the cultured cells. the urease was purified from supernatant fluid of sonicated cell of h. pylori cultured on blood agar for 2 days at 37 degrees c under microaerophilic condition. purification was carried out by deae-sepharose chromatography, phenyl-sepharose chromatography, sephacryl s-200 sf chromatography and fast protein liquid chromatography on mono-q. vero, hela and intestin 407 cells with or without the a ... | 1993 | 8409583 |
| [a study on the detection of helicobacter pylori in children with gastric and duodenal diseases]. | infection of hellcobacter pylori (h. pylori) in the gastric mucosa is said to participate in the pathogenesis of gastric and duodenal ulcers as well as gastritis. the detection rate of h. pylori in tissue specimens endoscopically taken from adult patients with these diseases was 75.2% (408/542). in affected children (2-15 yrs), on the other hand, 27 biopsies were performed in 22 cases but the initial positive rats was as low as 45.5%. according to the diagnosis, it was 75% for acute gastric muco ... | 1993 | 8409589 |
| [antibacterial activity of cefdinir and omeprazole against helicobacter pylori and their inhibition on h. pylori-producing urease]. | since helicobacter pylori is isolated very frequently from gastric ulcer specimens, the combination therapy of antimicrobial agent and proton pump inhibitor has recently been used. a study was made on whether cefdinir (cfdn), amoxicillin (ampc), metronidazole (mnz), omeprazole (opz), and omeprazole-m (opz-m) have antimicrobial activity against h. pylori and whether they can inhibit h. pylori-producing urease. 1) cfdn, ampc and mnz showed a potent antimicrobial activity against h. pylori, and esp ... | 1993 | 8409593 |
| [availability of determination of serum anti-helicobacter pylori igg antibody in diagnosis of helicobacter pylori infection]. | we studied on clinical availability of determination of serum anti-helicobacter pylori (hp) igg antibody in diagnosis of hp infection compared with bacterial culture. the population of this study consisted of patients who underwent endoscopic examination in our hospital. detection and quantification of hp were made by the culture of biopsy specimens taken from the antrum and the body of the stomach. and, simultaneously, serum anti-hp antibody (hp-ab) was measured by elisa. the levels of hp-ab in ... | 1993 | 8411745 |
| cloning, expression and sequencing of helicobacter felis urease genes. | urease genes from helicobacter felis were cloned and expressed in escherichia coli cells. a genomic bank of sau3a-digested h. felis chromosomal dna was created using a cosmid vector. cosmid clones were screened for urease activity following subculture on a nitrogen-limiting medium. subcloning of dna from an urease-positive cosmid clone led to the construction of pill205 (9.5 kb) which conferred a urease activity of 1.2 +/- 0.5 mumole urea min-1 mg-1 bacterial protein to e. coli hb101 bacteria gr ... | 1993 | 8412683 |
| more on the eradication of helicobacter pylori and the recurrence of duodenal ulcer. | 1993 | 8413426 | |
| [association and concordance of parameters of helicobacter pylori infection of gastric antrum mucosa]. | 1993 | 8415437 | |
| growth of helicobacter pylori in media containing cyclodextrins. | we show that solid and liquid media, supplemented only with cyclodextrins and free of blood and its derivatives, support the growth of helicobacter pylori. these media can be used for primary isolation of the bacteria from biopsy samples, routine laboratory growth, and large-scale industrial fermentation. | 1993 | 8417026 |
| helicobacter pylori serology. | 1993 | 8417028 | |
| adherence of helicobacter pylori to cultured human gastric epithelial cells. | experiments were performed to demonstrate that adherence of helicobacter pylori to gastric epithelial cells causes alterations in the cell cytoskeleton. h. pylori intimately attached to cultured human gastric epithelial cells on small cellular projections, while there was no intimate association of h. pylori with cultured human esophageal epithelial cells. fluorescein-conjugated phalloidin staining of gastric epithelial cells showed that h. pylori adherence stimulated actin polymerization; this ... | 1993 | 8418061 |
| biotype and molecular fingerprints of metronidazole-resistant strains of helicobacter pylori from antral gastric mucosa. | biotypes, ribosomal rna gene restriction patterns (ribopatterns), whole-cell protein patterns and plasmid profiles of paired helicobacter pylori isolates from 17 patients were examined. each pair comprised a pre- and a post-treatment isolate; nine of the 17 post-treatment isolates were obtained after treatment with tripotassium dicitrate bismuthate (de-nol) and metronidazole. all strains of h. pylori had identical biotypes, but exhibited diversity between pairs in their molecular fingerprints. e ... | 1993 | 8418295 |
| gastric interleukin-8 and iga il-8 autoantibodies in helicobacter pylori infection. | gastric infection with helicobacter pylori is frequently characterized by neutrophil infiltration. the production of the neutrophil-activating peptide (nap-1/il-8) and mucosal iga autoantibodies to il-8 by human antral biopsies have been examined during short-term in vitro culture. detectable il-8 was secreted by 84% of h. pylori-negative patients with normal antral mucosa (range < 0.07-61.5 ng/mg biopsy protein, n = 19). concentrations in 4 patients with reactive gastritis and 10 with inactive ... | 1993 | 8418474 |
| the helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin. | the gastric pathogen helicobacter pylori has been shown to produce a 19.6-kda protein with apparent binding activity for erythrocytes, human buccal epithelial cells, and laminin. in this report we demonstrate that it is an iron-binding protein, resembling ferritin both structurally and biochemically. also, because its binding activity for laminin, erythrocytes, and buccal cells was abolished by low concentrations of tween 20, binding is likely nonspecific. | 1993 | 8419304 |
| effect of ranitidine and amoxicillin plus metronidazole on the eradication of helicobacter pylori and the recurrence of duodenal ulcer. | persistent infection with helicobacter pylori is associated with the recurrence of duodenal ulcer. whether the efficacy of bismuth therapy in reducing the rate of recurrence of duodenal ulcer is due to its antimicrobial effects on h. pylori or to a direct protective action on the mucosa is still a matter of debate. | 1993 | 8419816 |
| treatment of peptic ulcers caused by helicobacter pylori. | 1993 | 8419823 |