Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| triple therapy with sucralfate is not effective in eradicating helicobacter pylori and does not reduce duodenal ulcer relapse rates. | the most used therapeutic schedule to eradicate helicobacter pylori is the "triple therapy," which is based on the simultaneous use of a bismuth salt and two antibiotics. sucralfate, a basic aluminum salt of sucrose sulfate, is supposed to have an antibacterial activity and is said to reduce the bacterial density of h. pylori. this randomized, prospective clinical trial compares the efficacy of an alternative oral triple therapy consisting of sucralfate, tinidazol, and tetracycline with a conven ... | 1994 | 8079927 |
| helicobacter pylori and refractory duodenal ulcers: cross-over comparison of continued cimetidine with cimetidine plus antimicrobials. | to determine the distribution of helicobacter pylori in the antral and duodenal mucosa of patients with duodenal ulcers refractory to 12 wk of treatment with cimetidine and to evaluate the effect of adding antimicrobial agents to cimetidine on the healing of refractory duodenal ulcers. | 1994 | 8079928 |
| effect of eradication of helicobacter pylori on serum pepsinogen i, gastrin, and insulin in duodenal ulcer patients: a 12-month follow-up study. | to understand the short-term and long-term effects of the eradication of helicobacter pylori on serum pepsinogen i, gastrin, and insulin concentration, we studied 53 patients with endoscopically proven duodenal ulceration and h. pylori infection. | 1994 | 8079929 |
| resolution of protein-losing hypertrophic lymphocytic gastritis with therapeutic eradication of helicobacter pylori. | lymphocytic gastritis (lg) is a recently described histological entity characterized by increased lymphocytes in the superficial gastric epithelium and foveolae. it includes a subgroup of patients with giant gastric folds and, often, a protein-losing state, a condition termed hypertrophic lymphocytic gastritis (hlg). despite close endoscopic and clinical similarities to classical menetrier's disease, the histopathological features of these two diseases are sufficiently distinct that they are reg ... | 1994 | 8079936 |
| maintenance treatment with ranitidine. | 1994 | 8079955 | |
| acid hypersecretion in duodenal ulcer patients. | 1994 | 8079956 | |
| short-term omeprazole oral/amoxicillin intravenous therapy for helicobacter pylori eradication: a lack of therapeutic effect. | 1994 | 8079960 | |
| helicobacter pylori in patients with rosacea. | 1994 | 8079962 | |
| ascorbic acid, helicobacter pylori and lewis phenotype among blacks and whites in new orleans. | gastric juice ascorbic acid concentrations were examined in black and white patients. significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin c between races. blacks had higher prevalence of helicobacter pylori infection, higher gastric ph, more severe acute and chronic inflammation of the gastric mucosa and higher frequency of lewis (a-b-) phenotype. although most of these factors have been related to low ascorbi ... | 1994 | 8080590 |
| examining the surface of a gastric pathogen. | 1994 | 8081647 | |
| helicobacter pylori: molecular basis for host recognition and bacterial adherence. | the bacterium helicobacter pylori is tropic for epithelial cells and the mucus layer in the stomach lining, and is associated with the development of gastritis, ulcers and possibly also gastric malignancies. adherence to the gastric epithelial cells is mediated by fucosylated blood-group antigens associated with blood-group o phenotype, which could explain the higher prevalence of ulcerative disease in individuals with this blood group. | 1994 | 8081648 |
| peptic ulcer surgery in 1994. | despite successful medical treatment of peptic ulcer disease regarding both acid reduction and eradication of helicobacter pylori, there is still an increasing number of emergency operations for complications and no decrease of mortality. elective surgery after complete physiologic work-up can improve the results for a certain group of patients. in cases requiring acid reduction only, laparoscopic procedures such as posterior truncal vagotomy and anterior seromyotomy can be offered. the minimal ... | 1994 | 8081937 |
| current aspects of gastroduodenal ulcer disease: diagnosis of pathophysiologic background and indications for operative therapy. | the management of gastroduodenal ulcer disease has changed because of new evidence of its pathophysiologic background and the introduction of new medication and operative techniques. proximal gastric vagotomy (pgv) was abandoned by some as the treatment of choice because of high recurrence rates. with the advent of minimally invasive surgery, laparoscopic vagotomy has renewed interest in vagotomy as a treatment option for gastroduodenal ulcer disease. in view of this development, a study was per ... | 1994 | 8081938 |
| primary antral gastritis in young american children. low prevalence of helicobacter pylori infections. | although helicobacter pylori (h. pylori) is considered by many to be the major cause of primary antral gastritis (pag), several important questions concerning its pathogenetic role remain unanswered. the most basic unresolved issue relates to the low prevalence of h. pylori in children in developed countries. if h. pylori is the cause of pag, the prevalence of pag should also be low, but previous studies have not provided data on this issue. to answer this question, we prospectively studied 408 ... | 1994 | 8082491 |
| [total peptic activity in gastric juice in patients with duodenal ulcer. variations in relation to age and role of helicobacter pylori]. | the aim of this study was to evaluate total peptic activity in gastric juice in duodenal ulcer patients in relation to age and helicobacter pylori infection. in duodenal ulcer patients peptic activity increases significantly in comparison to normal subjects. in relation to age there is no variation. therefore, gastric secretion has an autonomous behaviour independently of any physiological variation in healthy subjects. helicobacter pylori infection is present in 89.4% of duodenal ulcer patients ... | 1994 | 8084432 |
| testing negative for helicobacter pylori after methylene blue spraying of gastric mucosa. | 1994 | 8056268 | |
| development of a technique for detecting antimicrobial susceptibility of unculturable gastric spiral bacterium gastrospirillum hominis. | 1994 | 8056707 | |
| effectiveness of a five times daily triple therapy regimen against helicobacter pylori. | 1994 | 8056709 | |
| manifestation of symptoms in children infected with helicobacter pylori. | 1994 | 8057232 | |
| genetic analysis of the helicobacter pylori vacuolating cytotoxin: structural similarities with the iga protease type of exported protein. | the human gastric bacterial pathogen helicobacter pylori has been implicated in type b gastritis, peptic ulceration and gastric adenocarcinoma. here we report on the cloning and genetic characterization of an h. pylori gene named vaca, which encodes the vacuolating cytotoxin vaca, a novel type of antigenic bacterial toxin that induces the formation of intracellular vacuoles in epithelial cells. the vacuolating cytotoxin activity is expressed by a subset of clinical isolates (vac+), all of which ... | 1994 | 8057855 |
| helicobacter pylori and gastric lymphoma. | 1994 | 8058088 | |
| [helicobacter pylori and ulcer disease]. | 1994 | 8059463 | |
| peptic acid disease: strategies for treatment. | 1994 | 8060797 | |
| peptic ulcer disease--can we change its natural history? | 1994 | 8060798 | |
| difficulty in eradicating helicobacter pylori in a population at high risk for stomach cancer in venezuela. | the bacterium helicobacter pylori (hp) has been implicated in the etiology of precancerous lesions of the stomach and there is evidence suggesting that it may influence the efficacy of chemoprevention of gastric cancer with vitamin c. eradication seldom has been attempted in populations from developing countries, with a high prevalence of hp frequently resistant to metronidazole. a randomized, double-blind, controlled trial to evaluate the efficacy of colloidal bismuth subcitrate (120 mg q.i.d.) ... | 1994 | 8061173 |
| evaluation of two therapeutic regimens for the treatment of helicobacter pylori infection. | in the present study we evaluated the efficacy and tolerability of two different therapeutic schedules in eradicating helicobacter pylori. forty-six consecutive patients (suffering from either peptic ulcer or non-ulcer dyspepsia) with helicobacter pylori infection were randomly allocated to one of the following two groups: group 1 (n = 23) 2 weeks of treatment with bismuth subcitrate tablets (120 mgx4) + amoxycillin capsules (500 mgx4) + metronidazole tablets (250 mgx4); group 2 (n = 23) 2 weeks ... | 1994 | 8061335 |
| the role of helicobacter pylori in gastric carcinogenesis and in gastroduodenal disease. | 1994 | 8061588 | |
| helicobacter pylori: the link with gastric cancer. | gastric cancer is the world's overall second most common cancer, and carries a bad prognosis. in the correa model of gastric carcinogenesis, environmental factors (salt, nitrate, a lack of vitamin c and beta-carotene, bile reflux, bacterial overgrowth in atrophic gastritis with nitrosamine formation) are related to the evolution from normal gastric tissue through superficial gastritis, multifocal atrophic gastritis, intestinal metaplasia and dysplasia to carcinoma. the incidence of h. pylori dec ... | 1994 | 8061590 |
| chronic erosive gastritis on morphological analysis. | the present study was carried out to systematize the histopathological markers of chronic erosive gastritis referred to also as gastritis varioliformis (gv). the study population consisted of 74 patients aged 20 to 69 years with gastroscopic gv. the samples were obtained from the erosion site and representative areas of the prepyloric region and gastric body. in routine microscopic examinations we evaluated the severity, type and location of changes in the gastric mucosa. helicobacter pylori in ... | 1994 | 8062065 |
| human monoclonal antibodies from stomach carcinoma patients react with helicobacter pylori and stimulate stomach cancer cells in vitro. | in recent studies, an increased incidence of gastric adenocarcinomas was observed in patients with helicobacter pylori infection. however, the extent to which this coincidence is caused by immunologic mechanisms is unknown. | 1994 | 8062186 |
| assessment of four rapid urease test systems for detection of helicobacter pylori in gastric biopsy specimens. | an in vitro experiment and an in vivo clinical trial were both performed in order to assess the efficacy of four biopsy urease test systems, including one commercial kit, temmler cut test (temmler pharma, marburg, germany), for the rapid detection of helicobacter pylori. we first evaluated four rapid urease test systems by inoculating bacterial suspensions of different concentrations into urea-containing media and observing the color change at room temperature. we found that the cut test was sup ... | 1994 | 8062534 |
| predicting nsaid related ulcers--assessment of clinical and pathological risk factors and importance of differences in nsaid. | although ulcers are often associated with non-steroidal anti-inflammatory drugs (nsaids) little is known about the feasibility of predicting their development in patients taking nsaids. in addition, the ulcerogenic potentials of the newer nsaids, taken on long term basis, have not been compared with those of more established preparations. the aim of this study was to identify the clinical and pathological characteristics of patients at a higher risk of nsaid induced ulcers, measure the ulcerogen ... | 1994 | 8063215 |
| polymerase chain reaction assay for the detection of helicobacter pylori in gastric biopsy specimens: comparison with culture, rapid urease test, and histopathological tests. | ulcer recurrence is probably related to residual helicobacter pylori (h pylori). histological examination and culture are considered to be the most specific tests. clo test is a rapid but less specific test, which is usually used as an alternative test to culture. the aim of this study was to investigate the efficiency of a simplified polymerase chain reaction (pcr) assay as a procedure for the diagnosis of gastric h pylori infection of patients. biopsy specimens were obtained from antral mucosa ... | 1994 | 8063217 |
| effect of gastric ph on urease-dependent colonization of gnotobiotic piglets by helicobacter pylori. | thirty-seven gnotobiotic piglets from seven litters were infected with either helicobacter pylori n6 or urease-negative h. pylori n6ureg::km which contains an insertion in the ureg gene and produces inactive urease. to produce achlorhydria, piglets were treated throughout the experiment with omeprazole (5 mg intravenously every 12 h) and ranitidine (75 mg orally every 6 h). treatment resulted in elevation of gastric ph to 7.0 +/- 1.1 throughout the experiment. control piglets were not treated an ... | 1994 | 8063376 |
| interaction of lipopolysaccharides of helicobacter pylori with basement membrane protein laminin. | the ability of hemagglutinating and poorly hemagglutinating strains of the gastroduodenal pathogen helicobacter pylori to bind 125i-radiolabelled laminin was quantitated in a liquid phase assay. although all strains bound laminin, some hemagglutinating strains were good binders of laminin (maximum of 31% binding), whereas poorly hemagglutinating strains bound intermediate to small amounts of laminin (minimum of 6% binding). since a hydrophobic component of the bacterium has been reported to be i ... | 1994 | 8063380 |
| [the effect of superhigh-frequency electromagnetic radiation on the course of helicobacter pylori-associated peptic ulcer]. | the authors studied effects of microwave electromagnetic irradiation on the course of peptic ulcers and dissemination with helicobacter pylori in 60 patients with various severity of the disease. microwave irradiation not only hastens clinico-endoscopical remission of the disease but also considerably reduces dissemination of mucosa with helicobacter pylori. | 1994 | 8067031 |
| seroprevalence and associated risk factors of helicobacter pylori infection in taiwan. | in order to estimate the seroprevalence and explore multiple risk factors associated with helicobacter pylori infection among residents in taiwan, a total of 823 subjects randomly selected from one metropolitan precinct and three townships were studied. serum samples were tested for igg antibodies against h. pylori by enzyme-linked immunosorbent assay using commercial kits. the overall seropositive rate was 54.4% with no gender difference (53.7% for males and 55.2% for females). there was a sign ... | 1994 | 8067711 |
| the humoral immune response to helicobacter pylori infection in children with recurrent abdominal pain. | the systemic humoral immune response to helicobacter pylori antigens was investigated in 36 children with recurrent abdominal pain (rap). h. pylori was cultured and helicobacter-like organisms (hlo) were seen in six children, three of whom had active and two inactive chronic gastritis. none of these children had endoscopic abnormalities. all sex children had increased igg antibodies to heat-stable h. pylori antigens which were of the igg1 and igg3 subclasses. using six other igg tests, four of w ... | 1994 | 8068306 |
| culture of helicobacter pylori under aerobic conditions on solid media. | the aim of the present study was to culture helicobacter pylori under aerobic conditions and to investigate the characteristics of the organism when cultured aerobically. most (22 of 23) of the helicobacter pylori isolates grew under aerobic conditions, but with reduced viable cell counts. blood agar was more suitable than chocolate agar. the morphological and enzymatic characteristics as well as the protein profiles of each organism were identical under aerobic and microaerophilic conditions. h ... | 1994 | 8070454 |
| adaptation of helicobacter pylori to aerobic growth. | two of 23 strains of helicobacter pylori adapted from microaerobic to aerobic growth on blood agar plates incubated in humidified air. the air-adapted strains remained urease and phenylalanine deaminase positive and did not require the buffering effect of an enriched co2 atmosphere for growth. the significance of this phenomenon remains to be determined as the two strains capable of aerobic metabolism were laboratory-adapted. | 1994 | 8070455 |
| [optimal or maximum acid inhibition in ulcer therapy? a decision guide for routine general practice based on personal studies]. | the mucosal barrier in the stomach is complete only when the mucous layer has become saturated with bicarbonate. the latter arises as a waste product, as it were, of acid production in the parietal cell, but is then actively secreted via the surface epithelial cells and tight junctions. if the acid secretion is inhibited by means of drugs, the bicarbonate concentration also decreases. this situation probably occurs only when the bicarbonate batteries in the mucous layer and the surface epithelia ... | 1994 | 8070748 |
| duodenal ulcer treatment: progress from ph to hp. | the treatment of duodenal ulcer has evolved from ineffective medical treatments through an era of surgical management, back to increasingly effective medical treatment. the advent of h2-receptor antagonists changed the outlook for ulcer patients. more recently, helicobacter pylori, an organism which inhabits gastric mucosa exclusively, has been implicated in the pathogenesis of peptic ulcer. this bacterium is found in the stomachs of around 95% of duodenal ulcer patients. its eradication is show ... | 1994 | 8071396 |
| prevalence of helicobacter pylori in neonates and young infants undergoing ercp for diagnosis of neonatal cholestasis. | this study was carried out to determine the prevalence of helicobacter pylori infection in 20 neonates and young infants from lower socioeconomic background undergoing endoscopic retrograde cholangiopancreatography (ercp) examination for diagnosis of neonatal cholestasis. one young asymptomatic infant (5%) who was breast-feeding with complementary formula had h. pylori infection. endoscopy showed a normal appearing mucosa and histology demonstrated mild superficial acute gastritis. a follow-up g ... | 1994 | 8071783 |
| helicobacter pylori: trick or treat? | 1994 | 8071909 | |
| [importance of helicobacter pylori infection and pepsinogen titer in hemodialysis and renal transplantation patients in japan]. | helicobacter pylori (hp) infection is thought to play an important role in for the pathogenesis of atrophic gastritis and even gastric carcinoma. the ratio of pepsinogen i/ii (p i/ii) also shows good correlation with atrophic gastritis and gastric ulcer. since many hemodialysis (hd) and renal transplantation patients suffer from gastrointestinal problems, we investigated the importance of hp infection and p i/ii in these patients. serum hp igg was measured by eia. pepsinogen titer was measured w ... | 1994 | 8072224 |
| nucleotide sequence of the wolinella succinogenes flagellin, which contains in the antigenic domain two conserved regions also present in campylobacter spp. and helicobacter pylori. | wolinella succinogenes possesses one polar flagellum, which shows a characteristic surface pattern of parallel lines along the axis of the filament in electron microscopic images. we determined the gene sequence of the wolinella flagellin, which is, as in most other bacteria, the only structural component of the filament. sequence comparison with other members of the proteobacteria revealed two highly conserved regions in the central part of the flagellin molecule among campylobacter spp. and he ... | 1994 | 8051032 |
| serological detection of helicobacter pylori antibodies in children and their parents. | the antibody response to helicobacter pylori was examined in 56 children (ages 5 to 18) to determine whether serological tests can be used for diagnosis. twenty-four children (43%) were h. pylori positive and 32 children (57%) were h. pylori negative by culture and histological examination of endoscopic biopsy specimens. the immune response was also examined in 39 nonendoscoped parents of the children. h. pylori-specific immunoglobulin g (igg) and iga antibodies were detected by the flow microsp ... | 1994 | 8051244 |
| helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. | a bacterium with a spiral shape and bipolar, single, sheathed flagella was isolated from the livers of mice with active, chronic hepatitis. the bacteria also colonized the cecal and colonic mucosae of mice. the bacterium grew at 37 degrees c under microaerophilic and anaerobic conditions, rapidly hydrolyzed urea, was catalase and oxidase positive, reduced nitrate to nitrite, and was resistant to cephalothin metronidazole. on the basis of 16s rrna gene sequence analysis, the organism was classifi ... | 1994 | 8051250 |
| [helicobacter pylori and stomach cancer: "the signs should be traced all the way!"]. | 1994 | 8051996 | |
| [primary stomach lymphoma of the malt type. diagnosis and therapy. gastrointestinal lymphoma study group]. | primary gastric lymphoma are nowadays considered as a distinct lymphoma entity. their classification is based on the concept of malt (mucosa-associated lymphoid tissue). within the gastrointestinal tract, the stomach is most frequently involved. in the pathogenesis of gastric lymphoma, helicobacter pylori-associated gastritis plays an important, conditioning role. usually, the diagnosis of gastric lymphoma can be established on the basis of endoscopic biopsies. endoscopic ultrasound seems highly ... | 1994 | 8052089 |
| helicobacter pylori: a fickle germ. | the morphologic changes from bacillary to coccoid forms of helicobacter pylori were studied. these form changes were analyzed by bacterial growth in brucella broth plus 2% fetal calf serum. the coccoid forms were observed at five days of incubation and a rapid decrease of cfu/ml was recorded. at two weeks of microaerophilic incubation, all coccoid forms observed were not culturable in vitro. the coccoid morphology was observed earlier when the culture of h. pylori was incubated in aerobic condit ... | 1994 | 8052159 |
| [endoscopic findings in volunteers and dyspeptic patients]. | although more than a fourth of the adult population reports dyspeptic complaints, little is known about the prevalence of clinically relevant ugi endoscopic findings in these patients in comparison with asymptomatic volunteers. this type of information is required in order to assess the relative risks of organic dyspepsia and the sensitivity and specificity of dyspeptic complaints for peptic lesions. in an attempt to fill this gap, the authors compared two trials carried out in the german-speaki ... | 1994 | 8052829 |
| helicobacter pylori: consensus reached: peptic ulcer is on the way to becoming an historic disease. | 1994 | 8053422 | |
| double-blind comparison of lansoprazole, ranitidine, and placebo in the treatment of acute duodenal ulcer. lansoprazole study group. | to study in a double-blind controlled manner the effects of lansoprazole 15 mg or 30 mg daily compared with ranitidine 300 mg once daily and placebo in the relieving of symptoms and healing of acute duodenal ulceration. | 1994 | 8053433 |
| clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for helicobacter pylori infection. | metronidazole resistance has become an increasing problem that has limited the usefulness of the original triple therapy. our objective was to evaluate clarithromycin, a new macrolide compound active against helicobacter pylori. | 1994 | 8053435 |
| helicobacter pylori infection and serum pepsinogen a, pepsinogen c, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication. | to study the relationship between helicobacter pylori infection, gastric inflammatory scores, and fasting gastrin and pepsinogen a and c concentrations, and to evaluate the effect of treatment on these parameters. | 1994 | 8053437 |
| [evaluation of 4 media for the isolation of helicobacter pylori from gastric biopsies]. | different culture mediums were used for the isolation of helicobacter pylori. in this study three mediums commonly used for the culture of this microorganism were evaluated: chocolate agar, martin-lewis medium and cp of dent medium as well as a new selective medium pylori agar. | 1994 | 8031887 |
| helicobacter pylori alcohol dehydrogenase. | we have recently shown that 34 different helicobacter pylori strains of human and three of animal origin contain alcohol dehydrogenase (adh). isoelectric focusing of the enzyme showed activity bands with pi at 7.1-7.3, a pattern different from that of gastric mucosal adhs. the km value of h. pylori adh for ethanol oxidation ranges from 64 to 104 mm. although h. pylori adh was capable of utilizing both nadp and nad as cofactors in alcohol oxidation, it showed a strong preference for nadp over nad ... | 1994 | 8032149 |
| humoral and cellular immune recognition of helicobacter pylori proteins are not concordant. | helicobacter pylori is a major cause of chronic antral gastritis and peptic ulcer disease. further definition is needed of the factors that determine whether infected individuals remain asymptomatic, or ultimately develop ulceration of the mucosa or transformation to malignancy. to explore the possibility that host response to h. pylori may play a role in the outcome of this infection, we have examined humoral and cellular recognition of several h. pylori proteins by seropositive and seronegativ ... | 1994 | 8033409 |
| epidemiology and etiology of "autonomous" nonspecific duodenitis. | in this prospective study we looked for possible epidemiological and etiological factors in "autonomous" nonspecific duodenitis. of 136 dyspeptic patients who entered the study, duodenitis was found in 25.6% (94.4% chronic duodenitis and 5.6% isolated active duodenitis). men predominated with a significant prevalence of 74%; 49% of them had white-collar jobs, but age, psychological factors, and the season of the year played no role. we found that smoking and alcohol and coffee intake bore no rel ... | 1994 | 8034914 |
| helicobacter pylori and the anatomoclinical spectrum of duodenal ulcer disease. | 1994 | 8034924 | |
| is it infectious? | the autumn meeting of the english branch of the british society for the study of infection was held at the zoological society of london. speakers from a breadth of specialties re-examined the clinical features and pathology of some remarkably diverse illnesses and addressed the question 'is it infectious?' | 1994 | 8035006 |
| relationship between infective load of helicobacter pylori and reactive oxygen metabolite production in antral mucosa. | helicobacter pylori infection has been associated with stimulation of gastric mucosal reactive oxygen metabolite production. to provide further evidence of a causal relationship we looked for a dose-response relationship. we studied antral biopsy material from 110 patients. quantitative h. pylori assessments were made using histologic and microbiologic methods. reactive oxygen metabolite production was measured by luminol-dependent chemiluminescence. the usefulness of timed urease test colour ch ... | 1994 | 8036457 |
| mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with helicobacter pylori infection. | we investigated whether tumor necrosis factor-alpha (tnf-alpha), interleukin-1 beta (il-1 beta), and interleukin-8 (il-8) are involved in the inflammatory reaction of helicobacter pylori infection. in 23 patients with h. pylori infection and 16 patients with negative cultures for h. pylori and normal antral mucosa, the mucosal production of tnf-alpha, il-1 beta, and il-8 was measured in antral biopsy specimens after 23 h of in vitro culture. the levels of tnf-alpha and il-1 beta appeared to be s ... | 1994 | 8036458 |
| [the medical products agency in controversy with modern therapy of stomach ulcer]. | 1994 | 8046957 | |
| acetaldehyde and ethanol production by helicobacter pylori. | by virtue of possessing alcohol dehydrogenase activity, cytosol prepared from helicobacter pylori produces toxic acetaldehyde from ethanol in vitro. to approach the in vivo situation in the stomach, we have now investigation whether intact h. pylori--without addition of exogenous nicotinamide adenine dinucleotide--also forms acetaldehyde. furthermore, to assess the energy metabolism of h. pylori, we determined whether the alcohol dehydrogenase-catalyzed reaction can run in the opposite direction ... | 1994 | 8047804 |
| chronic nonatropic ('superficial') gastritis increases the risk of gastric carcinoma. a case-control study. | atrophic gastritis is a well-known risk condition for gastric carcinoma (gca). less is known about the risk of gca in subjects with nonatrophic ('superficial') gastritis. to investigate this, we estimated the risk of gca in patients with nonatrophic gastritis as compared with that in subjects with normal, nongastritic mucosa. two hundred and forty-three consecutive gca patients and 1408 non-gca outpatients (controls), for whom histologic data (endoscopic biopsy) of gastric mucosa was available, ... | 1994 | 8047808 |
| the role of helicobacter pylori in peptic ulcer disease. | there is now a persuasive body of evidence linking helicobacter pylori infection and peptic ulcer disease. over 90% of duodenal ulcer and 70% of gastric ulcer patients are infected with h. pylori. only a minority of infected patients develop ulcers, however, and host cofactors, rather than h. pylori strain, are probably critical to the development of peptic ulcer in infected individuals. conversely, not all ulcers are associated with h. pylori, and in these cases enterogastric reflux and non-ste ... | 1994 | 8047817 |
| the role of acid inhibition in the treatment of helicobacter pylori infection. | the recognition that helicobacter pylori is a causal factor in the development of most peptic ulcers (and may play a role in the pathogenesis of gastric cancer) has provided an impetus to the search for a suitable regimen that will eradicate the organism. combinations of antibiotics with bismuth (triple therapy) eradicate the organism in around 90% of cases, but the regimens are complicated, and poor compliance and significant side effects are frequently seen. the observation that omeprazole in ... | 1994 | 8047818 |
| the microbiology and epidemiology of helicobacter pylori infection. | helicobacter pylori is part of a genus of specialized bacteria that have adapted to the ecological niche provided by gastric mucus. h. pylori has exploited the human niche, while further species of helicobacter have inhabited the gastric mucosa of other animals. the preferred habitat of h. pylori is the gastric antrum. in humans with normal gastric function, the organism is mainly restricted to the antral surface, where a number of specialized traits allow it to flourish, while causing minimal h ... | 1994 | 8047819 |
| gastric cancer--a long-term consequence of helicobacter pylori infection? | chronic gastritis and chronic atrophic gastritis in particular are risk factors for gastric cancer. in western societies, for example finland, up to 70% of gastric cancer cases are associated with helicobacter pylori-positive chronic non-atrophic or atrophic gastritis, approximately 15% appear in conjunction with autoimmune chronic corpus-limited h. pylori-negative atrophic gastritis, and 15% develop in individuals with a histologically normal stomach. the role of h. pylori infection in chronic ... | 1994 | 8047820 |
| effects of eradication of helicobacter pylori on gastritis in duodenal ulcer patients. | the incidence and mean score of helicobacter pylori-related, active antroduodenitis, lesions of superficial antral epithelium and duodenal gastric-type metaplasia were higher in endoscopic biopsies from a large series of patients with duodenal ulcer, when compared with asymptomatic patients or patients with non-ulcer dyspepsia. in 65 out of 73 patients with duodenal ulcer who could be followed up, h. pylori was eradicated using a combination of amoxycillin, 3 g daily, metronidazole, 1 g daily, a ... | 1994 | 8047821 |
| emerging strategies for managing peptic ulcer disease. | the relationship between the inhibition of intragastric acidity and healing has been determined for both duodenal and gastric ulcers, with a stronger correlation being evident in duodenal ulcer. omeprazole is clearly more effective than h2-receptor antagonists in healing duodenal ulcers and in the resolution of attendant symptoms. as the recommended treatment periods are shorter with omeprazole (e.g. 2-4 weeks) than with h2-receptor antagonists (4-8 weeks), omeprazole has also been shown to be m ... | 1994 | 8047824 |
| pathophysiology of helicobacter pylori infection. | helicobacter pylori is now accepted as the major cause of chronic gastritis. the initial response to infection is acute neutrophilic gastritis, which progresses to active chronic gastritis in most people. to confirm the pathogenic role of h. pylori, both the individual histological features of chronic gastritis and its topographical patterns must be shown to be caused by the infection. surface epithelial degeneration is a probable result of direct tissue injury by bacterial products. candidates ... | 1994 | 8047828 |
| helicobacter pylori. | 1994 | 8048402 | |
| [functional dyspepsia, gastric emptying of solids, and helicobacter pylori infection]. | the origin of functional dyspepsia (fd) is unknown, however, abnormal gastric emptying and infection by h. pylori have been suggested as possible causes. | 1994 | 8049101 |
| familial clustering of helicobacter pylori infection. | 1994 | 8050260 | |
| helicobacter pylori is associated with alterations in intestinal gas profile among patients with nonulcer dyspepsia. | the pathogenesis of nonulcer dyspepsia (nud) is unknown. gas and postprandial bloating are frequent symptoms. the role of helicobacter pylori (hp) in the pathogenesis of nud is controversial. we studied the intestinal gas profile of nud patients (n = 34) at baseline and after lactulose administration. the prevalence of hydrogen and methane producers was similar among hp+ and hp- patients. breath h2 concentrations in response to lactulose showed significantly greater rise among hp+ subjects (p < ... | 1994 | 8050308 |
| gastrospirillum hominis prevalence. | 1994 | 8050309 | |
| helicobacter pylori in a costa rican dyspeptic patient population. | gastric biopsies from 65 costa rican dyspeptic patients were investigated for the presence of helicobacter pylori dna by polymerase chain reaction (pcr) amplification of 16s rrna sequences. both frozen and paraffin-embedded samples were used, and the results were compared with bacterial culture and histological examination. helicobacter pylori dna was detected by pcr in 60 (92%) of the patients, and helicobacter pylori strains confirmed by pcr could be isolated from 37 of them. altogether, 59 pa ... | 1994 | 8050440 |
| the entner-doudoroff pathway in helicobacter pylori. | evidence for the presence of the enzymes of the entner-doudoroff pathway in helicobacter pylori was obtained using 1h and 31p nuclear magnetic resonance spectroscopy. bacterial lysates generated 6-phosphogluconate and nadh or nadph in incubations with glucose-6-phosphate and nad+ or nadp+, indicating the presence of glucose-6-phosphate dehydrogenase activities. formation of pyruvate was observed in time courses of incubations of bacterial lysates with 6-phosphogluconate as the only substrate, su ... | 1994 | 8037447 |
| no effect of intramuscular gold therapy on serological parameters of helicobacter pylori infection in patients with rheumatoid arthritis: a 12 month prospective study. | to assess prospectively the influence of intramuscular gold therapy on helicobacter pylori serology in patients with rheumatoid arthritis (ra). | 1994 | 8037498 |
| phospholipase a2 activity in gastric juice from patients with active and h. pylori-eradicated healed duodenal ulcer. | despite the close association between gastric helicobacter pylori infection and duodenal ulcer, little is known about how this organism may promote mucosal damage. a possibility might be that it produces, or induces the host to release, phospholipases that metabolize the protective layer of phospholipids. | 1994 | 8038348 |
| preservation of gastric antral mucus is associated with failure of eradication of helicobacter pylori by bismuth, metronidazole and tetracycline. | forty-three patients positive for helicobacter pylori by histology and culture of antral biopsies (n = 40) or histology alone (n = 3) were investigated. they received either regimen 1--tripotassium dicitrato bismuthate 120 mg q.d.s. and tetracycline 250 mg q.d.s. for 4 weeks, with metronidazole 200 mg q.d.s. for the first 2 weeks, or regimen 2--omeprazole 20 mg b.d., amoxycillin 500 mg t.d.s., tetracycline 500 mg q.d.s. each for 3 weeks. gastric antral biopsies were scored (0-3) histologically f ... | 1994 | 8038349 |
| short report: omeprazole-tetracycline combinations are inadequate as therapy for helicobacter pylori infection. | current triple antimicrobial therapies cure helicobacter pylori infection in 60-90% of cases but are cumbersome. addition of omeprazole to amoxycillin has been shown to enhance effectiveness when compared to amoxycillin alone. | 1994 | 8038358 |
| peripheral neuropathy induced by metronidazole. | 1994 | 8038481 | |
| ulcer wars. | 1994 | 8038665 | |
| lipids of human gastric mucosa: effect of helicobacter pylori infection and nonalcoholic cirrhosis. | gastric mucosa phospholipids play an important protective role against exogenous and endogenous toxic agents. recently, we described a significant alteration of phospholipid profile in patients with chronic atrophic gastritis without helicobacter pylori infection. the aim of the present study was to assess the phospholipid composition of gastric biopsy specimens in 41 subjects with chronic gastritis in relation to h. pylori infection (no. 26) and nonalcoholic cirrhosis (no. 18). | 1994 | 8039613 |
| a urease-negative mutant of helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. | the urease of helicobacter pylori has been proposed to be one of its pathogenic factors. a kanamycin resistance determinant was inserted in a cloned urease gene, and transformation-mediated allelic exchange mutagenesis was carried out to introduce the disrupted gene into the corresponding wild-type chromosomal region of a clinical isolate of h. pylori, cpy3401. the resulting mutant, hpt73, had the null activity of urease. nude mouse stomachs were challenged with these two isogenic strains to exa ... | 1994 | 8039935 |
| successful immunization against gastric infection with helicobacter species: use of a cholera toxin b-subunit-whole-cell vaccine. | in previous studies we found that immunizing mice with a sonicate of helicobacter felis and adjuvant cholera toxin (ct; 10 micrograms) protected the animals against challenge with viable h. felis. the aim of this study was to determine whether a low dose of ct or its nontoxic b subunit (ctb) was effective as an adjuvant in helicobacter oral vaccines. significant protection against viable h. felis challenge was achieved in the animals immunized with h. felis antigen plus the combination of 0.5 mi ... | 1994 | 8039937 |
| parasitism by the "slow" bacterium helicobacter pylori leads to altered gastric homeostasis and neoplasia. | 1994 | 8040281 | |
| chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel helicobacter species. | in the autumn of 1992, a novel form of chronic, active hepatitis of unknown etiology was discovered in mice at the national cancer institute-frederick cancer research and development center (nci-fcrdc), frederick, md. a high incidence of hepatocellular tumors occurred in affected animals. the disease entity was originally identified in a/jcr mice that were untreated controls in a long-term toxicologic study. | 1994 | 8040890 |
| association of gastric metaplasia and duodenitis with helicobacter pylori infection in children. | helicobacter pylori infection causes chronic-active gastritis and is associated with peptic ulceration. however, the link between gastric h pylori colonization and duodenal ulcers is not well understood. therefore, a retrospective, case-controlled study was conducted to determine whether h pylori infection is associated with gastric metaplasia and mucosal inflammation in the duodenum. biopsy specimens from the duodenal bulb were obtained from 31 of 47 children with h pylori-induced gastritis. tw ... | 1994 | 8042587 |
| panel endorses antimicrobial therapy for ulcer disease. | 1994 | 8042627 | |
| [is duodenal ulceration an infectious disease]. | 1994 | 8045185 | |
| helicobacter pylori infection--gastritis, ulcers and gastric cancer. | 1994 | 8045776 | |
| helicobacter pylori infection and chronic active gastritis. | helicobacter pylori (h. pylori) is an s-shaped, gram-negative bacillus that recently has been implicated in the pathogenesis of chronic active gastritis and other peptic ulcer disease. these findings have encouraged gastroenterologists to provide a new rationale for patient management, with hope of providing more successful treatment of peptic ulcer disease, particularly gastritis. therefore, a cooperative diagnostic effort was made at the pathology laboratory of st francis medical center to ado ... | 1994 | 8045778 |
| [helicobacter pylori: a scientific paradigm?]. | it is analyzed from a historic philosophic view, the role which takes the discovery of the helicobacter pylori as an example like the way scientists proceed to build the scientific knowledge. the method for the philosophic interpretation of this find is based on the proposal of thomas kuhn who offers a historical description of the way, that science is taking form and developing. it is concluded that in the discovering of the helicobacter pylori and its theoretical implying concept and therapeut ... | 1994 | 8018903 |
| gastric ulcer in the elderly. | our experience shows that neither basal nor pentagastrin-stimulated acid, pepsin, pepsinogen group a and gastrin secretion significantly change across the age spectrum in subjects with peptic ulcer, even though the typical secretory patterns of patients with gu remain well-defined compared to those with duodenal ulcer (du), even in the later decades of life. very little is currently known about age-related changes in the various components of the gastric mucosal barrier; however, a significant r ... | 1994 | 8018978 |
| helicobacter pylori and pre-neoplastic and neoplastic gastric lesions. | the spiral bacterium helicobacter pylori has gained increasing interest as an important gastroduodenal pathogen since its isolation from the gastric mucosa. the presence of helicobacter pylori in the human stomach is closely associated with chronic gastric inflammatory disease and growing evidence suggests an aetiologic role of this organism in peptic disease. moreover, epidemiological and histological studies suggest that helicobacter pylori may be a risk factor for gastric carcinoma and primar ... | 1994 | 8018983 |