Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| radiotherapy management for squamous cell carcinoma of the nasal skin: the princess margaret hospital experience. | to evaluate the outcome of radiotherapy (rt) for squamous cell carcinoma (scc) of the nasal skin. | 2002 | 11958891 |
| clamp loaders and sliding clamps. | a coherent view of the structure and function of dna polymerase processivity factors (sliding clamps and clamp loaders) is emerging from recent structural studies. crystal structures of sliding clamps from the t4 and rb69 bacteriophages, and from an archaebacterium expand the gallery of ring-shaped processivity factors and clarify how the clamp interacts with the dna polymerase. crystallographic and electron microscopic views of clamp loaders from bacteria, archaebacteria and eukaryotes emphasiz ... | 2002 | 11959500 |
| radiation-induced osteochondroma of the t4 vertebra causing spinal cord compression. | a case of a radiation-induced osteochondroma arising from the vertebral body of t4 in an 18-year-old man is reported. the patient presented with a history of progressive left lower extremity weakness. at 7 years of age, he had undergone resection of a cerebellar medulloblastoma and received adjunctive craniospinal irradiation and systemic chemotherapy. both ct and mr imaging revealed an extradural mass contiguous with the posteroinferior endplate of the t4 vertebral body. this case indicates tha ... | 2002 | 11960236 |
| effect of wild-type, s15d and r175h p53 proteins on dna end joining in vitro: potential mechanism of dna double-strand break repair modulation. | balanced regulation of dna double-strand break (dsb) repair is crucial for genetic integrity and cell survival. cells perform dsb repair either by homologous recombination (hr) or by non-homologous end joining (nhej). either option carries risk for dna instability. the presence in the cell of the tumour suppressor p53 has been shown to suppress the levels of hr; however, the effect of p53 on dna ej is less well understood. here we demonstrate dramatically increased dna ej activity in cell-free e ... | 2002 | 11960905 |
| serum soluble interleukin-2 receptor as a predictor of lymph node metastasis in early gastric cancer. | in the present study, we investigated the clinical significance of serum soluble il-2r as a predictor of lymph node metastasis in patients with early gastric cancer. | 2002 | 11961349 |
| [the management of thyrotoxicosis: a schematic approach]. | thyrotoxicosis is a well defined clinical entity, determined by an increase of plasma levels of thyroid hormones (t3 and t4). a number of causes of thyrotoxicosis are known, and it is therefore very important for the treatment to establish its etiology. in fact, metimazole or propylthiouracil are indicated for the thyrotoxic states caused by thyroid gland's hyperfunction (hyperthyroidism), but are not effective when thyrotoxicosis is determined by a follicular damage and disruption with leakage ... | 2002 | 11961503 |
| [clinic-pathologic pattern and survival range in resectable gastric carcinoma]. | the present retrospective study evaluated 180 patients with resectable (group i ) and 128 patients with unresectable (group ii) gastric carcinoma at belen hospital, trujillo, peru, from 1966 to 1998, with the aim to identify the clinical and pathological features, actuarial survival rate and surgical morbidity and mortality rates of both groups. the mean age of the total series was of 58.3 + 14.8 years (range, 18 to 85 years). the most frequent symptoms in both groups were abdominal pain (89.4% ... | 2002 | 11961566 |
| effects of chronic mild stress on lymphocyte proliferative response. participation of serum thyroid hormones and corticosterone. | there is increasing evidence that stress produces changes in various immune processes. some of these changes may be due to neurochemical and hormonal alterations including thyroid hormones levels. this work was carried out to study the impact of chronic mild stress (cms) exposure on proliferative responses and its correlation with serum thyroid hormone levels. in addition, the influence of serum corticosterone levels on these responses was also studied. for this purpose, mice were submitted from ... | 2002 | 11962728 |
| [comparison of nicardipine and isradipine in hypertension following coronary artery bypass graft]. | compare the efficacy of isradipine to that of nicardipine for the control of arterial hypertension following coronary artery bypass graft (cabg). | 2002 | 11963384 |
| thyroid hormones are important for embryonic to larval transitory phase in zebrafish. | in zebrafish, like many other teleost species, the development and differentiation of many major organs continue unabated into the yolk-sac larval stage before culminating in a free-swimming larva capable of exogenous feeding. we investigated the role of thyroid hormone (th) in this important embryonic to larval transitory phase. thyroid hormone receptor (tr) alpha and beta mrnas are expressed during the early stages of zebrafish embryonic development. beginning from the midblastula stage, the l ... | 2002 | 11963654 |
| nucleation and propagation of the collagen triple helix in single-chain and trimerized peptides: transition from third to first order kinetics. | the kinetics of triple helix formation from single non-crosslinked peptide chains were studied for the collagen models (proprogly)10 and (prohypgly)10 in a broad concentration range and compared with those in nucleated trimers. at very low peptide concentrations the reaction order is 3 but decreases at higher concentrations. for (proprogly)10 the third order rate constant is 800 m(-2) x s(-1) at 7 degrees c, which corresponds to a very long half time of 15 hours at 60 microm chain concentration. ... | 2002 | 11922677 |
| malignant astrocytoma of the conus medullaris treated by spinal cordectomy. | we present a case of malignant astrocytoma of the conus medullaris in a 48-year-old man treated by spinal cordectomy. preoperative examination revealed a tumor at the t12 to l1 level, and intraparenchymal invasion up to t8. the spinal cord was amputated caudally to the root entry zones of the t9 sensory roots. additional cordectomies were repeated three times because of tumor infiltration at the cut end. at each procedure, the cord was segmentally transected just caudal to the root entry zones o ... | 2002 | 11922720 |
| sagittal plane correction in idiopathic scoliosis. | patients with idiopathic scoliosis who had undergone posterior fusion by means of posterior multisegmented hook instrumentation were studied retrospectively. | 2002 | 11923669 |
| [the structural biology and infection mechanism of bacteriophage t4]. | 2002 | 11925940 | |
| preoperative staging of rectal cancer using magnetic resonance imaging with external phase-arrayed coils. | rectal cancer can be accurately staged preoperatively by magnetic resonance imaging (mri) with external phase-arrayed coils. | 2002 | 11926950 |
| assembly of the bacteriophage t4 helicase: architecture and stoichiometry of the gp41-gp59 complex. | the bacteriophage t4 59 protein (gp59) plays an essential role in recombination and replication by mediating the assembly of the gene 41 helicase (gp41) onto dna. gp59 is required to displace the gp32 single-stranded binding protein on the lagging strand to expose a site for helicase binding. to gain a better understanding of the mechanism of helicase assembly, the architecture and stoichiometry of the gp41-gp59 complex were investigated. both the n and c termini of gp41 were found to lie close ... | 2002 | 11927580 |
| advanced proximal colon cancer. | two recent studies have documented that sigmoidoscopy as a screening tool for colorectal cancers may miss advanced proximal colonic neoplasms. the purpose of this study was to assess the prevalence of distal synchronous lesions in patients with proximal colon cancer. we sought to determine if screening sigmoidoscopy would have missed these proximal colon cancers. | 2002 | 11928025 |
| concomitant temporomandibular joint and orthognathic surgery: a preliminary report. | in the present study, we evaluated the outcome of concomitant temporomandibular joint (tmj) and orthognathic surgery in patients with tmj articular disc dislocation and coexisting dentofacial deformities. | 2002 | 11928087 |
| levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. | although the normal thyroid gland secretes both levothyroxine (l-t4) and levotriiodothyronine (l-t3), normalization of serum tsh with l-t4-replacement therapy alone in hypothyroidism is generally believed to result in a normal serum l-t3 and to reflect a euthyroid state. however several recent studies suggest that this may not be the case. accordingly, the relationship between serum free l-t4 and free l-t3 was examined in 20 normal individuals (group a) and in 53 patients with chronic autoimmune ... | 2002 | 11929079 |
| prognostic value of serial serum thyroglobulin determinations after total thyroidectomy for differentiated thyroid cancer. | serial weekly serum samples (for 3 weeks) were obtained from 42 patients with differentiated thyroid cancer (dtc, papillary no.=35, follicular no.=6, hurthle cell no.=1) for serum thyroid hormone, tsh and tg before and after total thyroidectomy. serum specimens were also obtained one month after radioiodine (131i) therapy followed by suppressive dose of l-thyroxine (l-t4, 2.5 microg/kg). the patients were subdivided into four groups: group i: the dtc was confined to a single solid nodule (no.=1 ... | 2002 | 11929080 |
| iopanoic acid rapidly controls type i amiodarone-induced thyrotoxicosis prior to thyroidectomy. | amiodarone-induced thyrotoxicosis (ait) may develop either in apparently normal thyroid glands (type ii ait) or in the presence of sub-clinical thyroid abnormalities (either autonomous goiter or latent graves' disease; type i ait). mixed forms also occur. while type i ait is due to iodine-induced excess thyroid hormone synthesis, type ii ait is a form of amiodarone (possibly iodine) -induced destructive thyroiditis. type i ait is usually treated by combined thionamide and potassium perchlorate t ... | 2002 | 11929091 |
| obligate bacterial endosymbionts of acanthamoeba spp. related to the beta-proteobacteria: proposal of 'candidatus procabacter acanthamoebae' gen. nov., sp. nov. | all obligate bacterial endosymbionts of free-living amoebae currently described are affiliated with the alpha-proteobacteria, the chlamydiales or the phylum cytophaga-flavobacterium-bacteroides. here, six rod-shaped gram-negative obligate bacterial endosymbionts of clinical and environmental isolates of acanthamoeba spp. from the usa and malaysia are reported. comparative 16s rdna sequence analysis demonstrated that these endosymbionts form a novel, monophyletic lineage within the beta-proteobac ... | 2002 | 11931173 |
| highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of t4 bacteriophage fibritin. | the envelope glycoproteins of human immunodeficiency virus type 1 (hiv-1) function as a trimer composed of three gp120 exterior glycoproteins and three gp41 transmembrane proteins. soluble gp140 glycoproteins composed of the uncleaved ectodomains of gp120 and gp41 form unstable, heterogeneous oligomers, but soluble gp140 trimers can be stabilized by fusion with a c-terminal, trimeric gcn4 motif (x. yang et al., j. virol. 74:5716-5725, 2000). to understand the influence of the c-terminal trimeriz ... | 2002 | 11932429 |
| abnormalities of hypothalamic-pituitary-thyroid axis in patients with primary empty sella. | primary empty sella (pes) is a very frequent neuroradiological finding in the general population, that can induce hypopituitarism. some studies focused on the association of pes with gh deficiency (ghd) or hypogonadotropic hypogonadism (hh), while data regarding the involvement of hypothalamic-pituitary-thyroid (hpt) axis, despite sporadic reports of central hypothyroidism, or the occurrence of hypoadrenalism (ha) are scanty. in this study, thyroid function and tsh response to exogenous trh inje ... | 2002 | 11936465 |
| action of thyroid hormone in brain. | among the most critical actions of thyroid hormone in man and other mammals are those exerted on brain development. severe hypothyroidism during the neonatal period leads to structural alterations, including hypomyelination and defects of cell migration and differentiation, with long-lasting, irreversible effects on behavior and performance. a complex regulatory mechanism operates in brain involving regulation of the concentration of the active hormone, t3, and the control of gene expression. mo ... | 2002 | 11936472 |
| [prognosis of primary cutaneous lymphomas]. | the assessment of prognosis is a major step in the management of primary cutaneous lymphomas, as it allows to give patients an accurate information and it directs the treatment choice. | 2002 | 11937927 |
| [factors associated with change in diabetes knowledge from childhood to adolescence]. | a multicentric cohort of 142 children with insulin-dependent diabetes has been longitudinally studied to evaluate if their diabetes knowledge was modified by time and to assess the factors associated to this change. | 2002 | 11938031 |
| current concepts in gastric cancer surgery. | current problems in gastric cancer surgery concern the extent of gastric resection, the need for abdominal evisceration, the degree of lymphadenectomy, and an optimal preoperative tumor staging procedure. | 2002 | 11938366 |
| simplified staging for hepatocellular carcinoma. | the current american joint committee on cancer (ajcc) staging system for hepatocellular carcinoma (hcc) fails to stratify patients adequately with respect to prognosis. | 2002 | 11896101 |
| modified immunoenriched (32)p-hplc assay for the detection of o(4)-ethylthymidine in human biomonitoring studies. | increased excretion of ethylated dna bases has been reported in the urine of cigarette smokers. to study dna ethylation in the target organs of smokers, an immunoenriched (32)p-postlabeling assay for o(4)-ethylthymidine (o(4)-ett) was developed. o(4)-ett-3'-monophosphate (o(4)-ett-3'p) was synthesized, purified, and characterized by lc-ms, esi-ms, and nmr. dna was enzymatically digested to 2'-deoxynucleoside-3'-monophosphate followed by immunoprecipitation of o(4)-ett-3'p using specific monoclon ... | 2002 | 11896692 |
| protein turnover, lipolysis, and endogenous hormonal secretion in critically ill children. | the catabolic state is a major contributor to morbidity and mortality of critical illness and may be related to endocrine changes. we studied whether protein and lipid turnover correlate with insulin and growth and thyroid hormone plasma levels in critically ill infants. | 2002 | 11902289 |
| intestinal epithelial lesions associated with signet ring cell carcinoma of the colon and small intestine. | the purpose of this study was to investigate the epithelial lesions associated with signet ring cell carcinoma (srcc) of the colon and small intestine and the possible mechanism of tumour development. | 2002 | 11902446 |
| identification of two middle promoters upstream dna ligase gene 30 of bacteriophage t4. | bacteriophage t4 dna ligase gene 30 lies in the cluster of prereplicative genes located counterclockwise from map units 149 to 121. based on the early transcription studies this gene has been considered as a typical early gene of bacteriophage t4. in agreement with this assignment, two strong t4 early promoters, p(e )30.8 (128.6) and p(e )30.7 (128.2), located about 3.1 and 2.7 kb upstream from gene 30 have been revealed by promoter mapping and sequence analysis. in addition, the existence of a ... | 2002 | 11902835 |
| [strategy of neck dissection in parotid cancer]. | we conducted definitive surgery on 45 patients with untreated primary parotid cancer from 1975 to 1995, and evaluated methods of neck dissection and results of treatment. all 14 with clinical neck lymph node metastasis underwent ipsilateral radical neck dissection and only 1 developed neck lymph node recurrence at the peripheral dissected site. of 31 patients without clinical neck lymph node metastasis, 27 of 19 of 36 with high-grade malignancy and 12 of 24 with t3 or t4 did not undergo prophyla ... | 2002 | 11905056 |
| a low-selenium diet increases thyroxine and decreases 3,5,3'triiodothyronine in the plasma of kittens. | the effect of a low-selenium diet on thyroid hormone metabolism was investigated in growing kittens. twelve specific-pathogen-free kittens with ages ranging from 16 to 18 weeks were divided into two groups of equal number with equal sex distribution in each group. one group was fed a yeast-based low-selenium diet (0.02 mg se/kg diet) while the other group was fed the same diet supplemented with na2seo3 at 0.4 mg se/kg diet for 8 weeks. food intake, body weight and body weight gain were not affec ... | 2002 | 11906571 |
| effect of strand orientation on the interaction of berenil with dna triple helices. | using circular dichroism spectroscopy the ability of berenil, a minor groove binding drug, to induce triple helix formation was investigated with two oligonucleotides designed to form two intramolecular triplexes containing t*a:t and g*g:c triplets, which differ only by the orientation of their third strand: 5'-d(g4a4g4-[t4]-c4t4c4-[t4]-g4t4g4), and 5'-d(g4t4g4-[t4]-g4a4g4-[t4]-c4t4c4), where [t4] represents a stretch of four thymine residues. we demonstrate that when added to the duplex form of ... | 2002 | 11908854 |
| renal na-k-cl cotransporter nkcc2 in dahl salt-sensitive rats. | dahl salt-sensitive (ds) rats are characterized by enhanced nacl reabsorption in the loop of henle, but the responsible ion transport protein is unknown. | 2002 | 11910309 |
| gastric phytobezoar associated with impaired gastric motility in a patient with spinal cord injury. | impaired gastrointestinal motility as a result of interruption of sympathetic outflow is a common occurrence in the spinal cord injury (sci) population. in addition, frequent use of medications with anticholinergic properties in this population results in further impairment of peristalsis resulting in gastrointestinal stasis. since sci patients often lack sensation below the level of injury, they may present with vague symptoms, which complicates the diagnosis of intestinal obstruction. we repor ... | 2002 | 11939466 |
| iodine species and the endocrine system: thyroid hormone levels in adult danio rerio and developing xenopus laevis. | recently a new approach for the analysis of iodinated organic species in human serum has been developed using liquid chromatography-inductively coupled plasma-mass spectrometry (lc-icp-ms). this method enables quantification of iodide, t4 and t3, as well as reverse t3 (rt3) and the synthetic precursors of th, monoiodotyrosine (mit), and diiodotyrosine (dit) in a single injection. in this work, the lc-icp-ms approach was used to analyze whole-body homogenates of adult male and female zebrafish (d ... | 2002 | 11939537 |
| manganese substantially alters the dynamics of translesion dna synthesis. | the effect of metal ion substitution on the dynamics of translesion dna synthesis catalyzed by the bacteriophage t4 dna polymerase was quantitatively evaluated through steady-state and transient kinetic techniques. substitution of mn(2+) for mg(2+) enhances the steady-state rate of dnmp misinsertion opposite an abasic site by 11-34-fold. at the molecular level, the enhancement in translesion dna synthesis reflects a substantial increase in the rate of the conformational change preceding phosphor ... | 2002 | 11939771 |
| a case of idiopathic spinal epidural lipomatosis presented with radicular pain caused by compression with enlarged veins surrounding nerve roots. | to report a case of idiopathic spinal epidural lipomatosis (sedl) presented with unique radicular pain most likely caused by enlarged veins surrounding nerve roots. | 2002 | 11939947 |
| mutations linked to familial hypokalaemic periodic paralysis in the calcium channel alpha1 subunit gene (cav1.1) are not associated with thyrotoxic hypokalaemic periodic paralysis. | to investigate whether patients with thyrotoxic hypokalaemic periodic paralysis (thpp) have the same molecular defect in the calcium channel gene described in familial hypokalaemic periodic paralysis (fhpp), as the symptoms of both diseases are comparable, we analysed, in patients with thpp, the presence of mutations r528h, r1239h and r1239g on the s4 voltage-sensing transmembrane segment of the alpha1 subunit of the calcium channel gene (cav1.1). | 2002 | 11940049 |
| pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in québec. | concentrations of polychlorinated biphenyls (pcbs), hydroxylated metabolites of pcbs (ho-pcbs) and octachlorostyrene (4-ho-hpcs), and pentachlorophenol (pcp) were determined in umbilical cord plasma samples from three different regions of québec. the regions studied included two coastal areas where exposure to pcbs is high because of marine-food-based diets--nunavik (inuit people) and the lower north shore of the gulf of st. lawrence (subsistence fishermen)--and a southern québec urban center wh ... | 2002 | 11940460 |
| [prognostic value of peritoneal lavage cytology in gastric cancer]. | the microscopic detection of free peritoneal tumour cells in peritoneal lavage fluid in gastric cancer patients is a useful predictor of peritoneal recurrence and poor prognosis. the aim of this study was to verify the prognostic significance of intraoperative peritoneal lavage cytology and its value as a predictor of peritoneal recurrence. we evaluated the presence of free peritoneal tumour cells with extemporary cytological examination in a series of 170 peritoneal washing samples from patient ... | 2002 | 11941998 |
| kinesiological study of the push-up motion in spinal cord injury patients: involving measurement of hand pressure applied to a force plate. | we studied the pressure exerted by hands during push-ups in 21 paraplegic and 2 tetraplegic patients employing 4 different hand positions. in the fingers-spread position, the initial force exerted was a vertical force (fz), followed by a medio-lateral force (fy) and then an antero-posterior force (fx). in the other 3 positions, the order of force type exertion was fz, fx, and then fy. all subjects with neurological injury levels above t4 and subjects between t5 and t10 without spinal instrumenta ... | 2002 | 12002621 |
| the benefit of neurogenic mixed evoked potentials for intraoperative spinal cord monitoring during correction of severe scoliosis: a case study. | a case report is presented. | 2002 | 12004186 |
| ki-67 staining is an independent correlate of biochemical failure in prostate cancer treated with radiotherapy. | to determine the significance of ki-67/mib1 staining as a marker of patient outcome for prostate cancer patients treated with radiotherapy. | 2002 | 12006531 |
| prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-fluorouracil and cisplatin for t4 esophageal cancer with or without fistula. | a prospective trial of concurrent chemoradiotherapy (ct-rt) with a protracted infusion of 5-fluorouracil and cisplatin was performed to evaluate the safety and efficacy of this protocol for t4 esophageal cancer (uicc 1997). | 2002 | 12007951 |
| tsh secretory pattern and thyroid function in children with growth hormone neurosecretory dysfunction. | we evaluated the tsh secretory pattern and free t4 in 10 prepubertal children with short stature, normal response to gh provocative tests, and reduced gh integrated concentration (ic-gh) (gh neurosecretory dysfunction). although their nadir tsh, peak tsh, tsh surge, and free t4 were lower than those of 12 children with short stature and normal ic-gh, none of the differences reached statistical significance. thus, our results suggest that children with low ic-gh (gh neurosecretory dysfunction) ex ... | 2002 | 12008683 |
| neo-adjuvant treatment of infiltrating transitional-cell carcinoma of the bladder with paclitaxel and cisplatin: a phase ii trial. | a phase ii multicentric trial of paclitaxel and cisplatin was conducted in previously untreated patients, with locally advanced transitional-cell carcinoma (tcc) of the bladder, to assess its toxicity and efficiency in preserving the bladder. | 2002 | 12010328 |
| uptake of triiodothyronine and triiodothyroacetic acid in neonatal rat cardiomyocytes: effects of metabolites and analogs. | cellular and nuclear uptake of [125i]tri-iodothyronine (t3) and [125i]triiodothyroacetic acid (triac) were compared in cardiomyocytes of 2-3 day old rats, and the effect of thyroid hormone analogs on cellular t(3) uptake was measured. cells (5-10 x 10(5) per well) were cultured in dmem-m199 with 5% horse serum and 5% fcs. incubations were performed for from 15 min to 24 h at 37 degrees c in the same medium, 0.5% bsa and [125i]t3 (100 pm), or [125i]triac (240 pm). expressed as % dose, t(3) uptake ... | 2002 | 12010632 |
| interleukin-2 and 13-cis retinoic acid in the treatment of minimal residual disease: a phase ii study. | interleukin-2 (il-2) which has no cross-resistance with chemotherapy, has given responses in tumors resistant to chemotherapy, and shown to be more effective when tumor burden is low. 13-cis retinoic acid (ra) has immunomodulatory properties, potentially synergistic with il-2. the objective of this pilot phase ii study was to verify the immunomodulatory properties, activity and toxicity of outpatient immunotherapy with subcutaneous low dose il-2 and oral ra, identified in a previous phase-i stud ... | 2002 | 12012010 |
| transient hypothyroxinemia of prematurity is associated with abnormal cranial ultrasound and illness severity. | transient hypothyroxinemia without elevated thyroid-stimulating hormone (tsh) levels is common in prematurity, especially in very-low-birth-weight (vlbw) infants. the transient hypothyroxinemia of prematurity (thop) has been seen as a "benign" condition not requiring medical treatment. however, some recent large observational studies have revealed a relationship between thop and abnormal neurodevelopment. furthermore, one study showed thop had twice the risk of brain echolucency, which was the b ... | 2002 | 12012289 |
| temporal and spatial variation in plasma thyroxine (t4) concentrations in juvenile alligators collected from lake okeechobee and the northern everglades, florida, usa. | we examined variation in plasma thyroxine (t4) in juvenile american alligators (alligator mississippiensis) collected from three sites within the kissimmee river drainage basin (fl, usa). based on historical sediment data, moonshine bay served as the low contaminant exposure site, water conservation area 3a served as an intermediate contaminant exposure site, and belle glade served as the high contaminate exposure site. in may 1999, alligators (n = 22) from water conservation area 3a exhibited h ... | 2002 | 12013137 |
| activation of stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis. | the jak/stat signaling pathway transmits signals from many cytokines and growth factor receptors to target genes in the nucleus. constitutive activation of stat-3 recently has been observed in many tumor cells, and dysregulation of the stat signaling pathway has been proposed to be implicated in malignant transformation. in the current study for the first time to the authors's knowledge, the expression of stat-3 was analyzed in various stages and sites of squamous cell carcinoma of the head and ... | 2002 | 12015764 |
| [paraparesis and sensory spinal cord transection caused by an nk-cell lymphoma]. | a 42-year-old man of russian origin was admitted because of fever, nocturnal sweating and weight loss. within 2 days a paraparesis of the legs and a bladder-colon disorder had developed. neurological examination suggested a spinal cord lesion at t4 and hypaesthesia from t9 downward. | 2002 | 12016554 |
| backbone assignments for endonuclease v from bacteriophage t4 with deuterium labeling. | 2002 | 12018491 | |
| thoracic myelopathy complicating acute meningococcal meningitis: mri findings. | spinal cord dysfunction is a rare complication of neisseria meningitidis (meningococcal) meningitis. we report a 17-year-old patient who had a 3-day history of fever, headache and vomiting, agitation, and unresponsiveness. cerebrospinal fluid showed a marked polymorphonuclear pleocytosis. latex particle agglutination was positive for meningococci. the patient was given intravenous antibiotics and intravenous dexamethasone. over the next 4 days, he developed weakness of the lower extremities, wit ... | 2002 | 12018669 |
| neck dissection prior to radiation therapy for squamous cell carcinoma of tongue base. | squamous cell carcinoma of the tongue base can be treated with comparable control and survival rates when neck dissection (nd) is performed before radiation therapy (rt). | 2002 | 12019481 |
| influences of early thyroid hormone manipulations: delays in pup motor and exploratory behavior are evident in adult operant performance. | the effects of thyroid hormone depletion and enhancement on litter size, survival, body mass, ambulation, quadrant crossing, home orientation, day of eye opening, and free serum t3 and t4 levels were examined in study 1. in study 2, the effects of the timing of prenatal insult and the level of thyroid hormone depletion on litter size, survival, body mass, and free serum t3 and t4 levels were examined. upon the completion of study 1, randomly selected pups were maintained on ad-libitum water and ... | 2002 | 12020735 |
| clinical, hormonal, and hematologic characteristics of bovine calves derived from nuclei from somatic cells. | although healthy animals are born after nuclear transfer with somatic cells nuclei, the success of this procedure is generally poor (2%-10%) with high perinatal losses. apparently normal surviving animals may have undiagnosed pathologies that could develop later in life. the gross pathology of 16 abnormal bovine fetuses produced by nuclear transfer (nt) and the clinical, endocrinologic (insulin-like growth factors i and ii [igf-i and igf-ii], igf binding proteins, post-acth stimulation cortisol, ... | 2002 | 12021036 |
| unusual survival for more than 2 years with peritoneal metastases of gastric cancer. | we report a patient with peritoneal metastases who was successfully treated with a novel oral fluoropyrimidine anticancer drug, ts-1, as first-line chemotherapy. the patient was a 72-year-old man who had undergone curative resection for type 4 gastric cancer with peritoneal dissemination that was located only at the greater omentum. final findings were p1, t4, n1, and stage iv. eighteen months after the gastrectomy, his cancer recurred with peritoneal metastases; these were diagnosed by the pres ... | 2002 | 12021860 |
| usefulness of videothoracoscopic intrapericardial examination of pulmonary vessels to identify resectable clinical t4 lung cancer. | discrepancies in predicting resectability by imaging techniques (computed tomography and magnetic resonance imaging) compared with actual intraoperative findings have persuaded us to perform systematic exploratory videothoracoscopy (evt) as the first step in the surgical evaluation of patients with lung cancer. resectability of centrally located primary tumors with intrapericardial extension (clinical t4), however, can be established only by direct examination of the pericardial sac contents. th ... | 2002 | 12022550 |
| one hundred consecutive cases of sentinel lymph node mapping in early colorectal carcinoma: detection of missed micrometastases. | almost one third of patients with "node-negative" colorectal carcinoma (crc) develop systemic disease. this implies that these patients have occult disease that is inadequately treated by surgery alone. we have coupled sentinel lymph node mapping and a focused pathologic examination to detect occult nodal micrometastases in crc. since 1996, sentinel lymph node mapping has been performed in 100 consecutive patients undergoing colectomy for crc. peritumoral injection of 0.5 to 1.0 ml of isosulfan ... | 2002 | 12022982 |
| improvement of local control of t3 and t4 nasopharyngeal carcinoma by hyperfractionated radiotherapy and concomitant chemotherapy. | when the primary tumor of nasopharyngeal carcinoma (npc) is treated at the base of skull and intracranium with conventional radiotherapy, the result is generally poor. in this report, we investigated whether hyperfractionated radiotherapy (hfrt) and concomitant chemotherapy (cct) could achieve better local control and survival in npc patients with t3 and t4 lesions. | 2002 | 12023138 |
| goiter in rural area of aligarh district. | the survey of iodine deficiency disorder (idd) and an inquiry about intake of goitrogenic items in two villages of the aligarh district with a population of 1819 was done. out of 1152 subjects examined, 348 had goiters but no other abnormality related to the idd could be found in these subjects. the goiter positivity was 30.2% with visible goiter (grade ii & iii) rate 8.5%. six of the subjects had multi nodular goiter of grade iii. urinary iodine levels in 316 of the goitrous subjects were lower ... | 2002 | 12024947 |
| side rail use and bed-related fall outcomes among nursing home residents. | to analyze the effect of physical restraint reduction on nighttime side rail use and to examine the relationship between bilateral side rail use and bed-related falls/injuries among nursing home residents. | 2002 | 12028252 |
| [m protein gene (emm) typing of streptococcus pyogenes]. | t-agglutination typing and m protein gene (emm) typing were determined on the isolates of streptococcus pyogenes taken from patients in osaka and neighboring districts during 1996-2000. a total of 701 isolates were classified to 15 kinds of t types and type untypable. in all isolates, t 12 was revealed as the most dominant serotype, followed by t1, t4 and t2. the isolation rates of t 12 strains were high through these five years, and these of t1 or t4 strains formed epidemic waves showing the pe ... | 2002 | 12030021 |
| blood coagulation and fibrinolysis in patients with hyperthyroidism. | several papers concerning abnormalities of blood coagulation and fibrinolysis during hyperthyroidism, have been published. increased von willebrand factor (vwf) activity and high fibrinogen levels have been reported. however, there is controversy concerning the presence of a hypercoagulable state in hyperthyroidism. we investigated various hemostatic parameters in 41 hyperthyroid patients and compared them to 20 euthyroid controls. prothrombin time (pt), activated partial thromboplastin time (ap ... | 2002 | 12030606 |
| comparison of the mechanisms of nongenomic actions of thyroid hormone and steroid hormones. | steroids and thyroid hormone are thought primarily to act via binding to hormone-specific nuclear receptor superfamily members. the nuclear ligand-receptor complexes then initiate transcriptional activity. actions of steroids and iodothyronines that are nongenomic or extranuclear in mechanism have been recognized recently and new insights into such mechanisms are available. despite their distinct structures and biologic effects, the two families of hormones have similarities in the mechanisms of ... | 2002 | 12030612 |
| the quantity of thyroid hormone in human milk is too low to influence plasma thyroid hormone levels in the very preterm infant. | thyroid hormone is crucial for brain development during foetal and neonatal life. in very preterm infants, transient low levels of plasma t4 and t3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. we investigated whether breast milk is a substantial resource of thyroid hormone for very preterm neonates and can alleviate transient hypothyroxinaemia. both the influence of breast feeding on plasma thyroid hormone levels and the thyroid hormone concentratio ... | 2002 | 12030913 |
| the combined administration of gh-releasing peptide-2 (ghrp-2), trh and gnrh to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with ghrp-2 alone. | central hyposomatotrophism, hypothyroidism and hypogonadism are present concomitantly in men with prolonged critical illness. this study evaluated the impact of combined treatment with gh-releasing peptide-2 (ghrp-2), trh and gnrh for 5 days compared with ghrp-2 + trh and with ghrp-2 alone. | 2002 | 12030918 |
| involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. | the efficient repair of double-strand breaks (dsbs) in dna is critical for the maintenance of genome stability. in mammalian cells, repair can occur by homologous recombination or by non-homologous end joining (nhej). dna breaks caused by reactive oxygen or ionizing radiation often contain non- conventional end groups that must be processed to restore the ligatable 3'-oh and 5'-phosphate moieties which are necessary for efficient repair by nhej. here, using cell-free extracts that efficiently ca ... | 2002 | 12032095 |
| biosensor for the enantioselective analysis of the thyroid hormones (+)-3,3',5-triiodo-l-thyronine (t3) and (+)-3,3',5,5'-tetraiodo-l-thyronine (t4). | an amperometric biosensor based on l-aminoacid oxidase is proposed for enantioselective assay of (+)-3,3',5-triiodo-l-thyronine (l-t3) and (+)-3,3',5,5'-tetraiodo-l-thyronine (l-t4), due to the fact that only the l enantiomer has the hormonal activity. the construction of the amperometric biosensor is simple and reproducible. the analytical information obtained from enantioselective analysis are reliable. the rsd <1% assured by using the amperometric biosensors for l enantiomers assay as raw mat ... | 2002 | 12033642 |
| effects of edta and sodium citrate on hormone measurements by fluorometric (fia) and immunofluorometric (ifma) methods. | background: measurements of hormonal concentrations by immunoassays using fluorescent tracer substance (eu3+) are susceptible to the action of chemical agents that may cause alterations in its original structure. our goal was to verify the effect of two types of anticoagulants in the hormone assays performed by fluorometric (fia) or immunofluorometric (ifma) methods. methods: blood samples were obtained from 30 outpatients and were drawn in edta, sodium citrate, and serum separation vacutaine&rc ... | 2002 | 12033989 |
| thyroid hormone autoantibodies in primary sjögren syndrome and rheumatoid arthritis are more prevalent than in autoimmune thyroid disease, becoming progressively more frequent in these diseases. | to verify the greater prevalence of circulating thyroid hormone autoantibodies (thab) in primary sjogren syndrome (ss) vs hashimoto's thyroiditis (ht) and graves' disease (gd), we measured thab in the serum of patients with these 3 diseases who were sampled from 1998-1999 (no.=20, 88, 25) and 1990-1992 (no.=13, 75, 31). patients with rheumatoid arthritis (ra) (no.=23 and 16) and other collagenoses (no.=20 and 16) were also studied. a third series of patients with these 5 diseases was studied fro ... | 2002 | 12035942 |
| hypothyroid hashimoto's thyroiditis with scintigraphic and echo-color doppler features mimicking autonomous adenoma. | we investigated a 48-yr-old woman on l-t4 therapy (100 microg/d) for primary autoimmune hypothyroidism, diagnosed 15 yr earlier, presenting a firm oval lump in the right thyroid lobe and symptoms of mild thyrotoxicosis. free t4, free t3, tsh, anti-thyroperoxidase, anti-tg and anti-thyroid microsomal antibodies were determined. thyroid us and color flow doppler sonography (cfds), 99mtechnetium (99mtc), radioiodine scintiscan and us guided fine needle aspiration cytology (fnac) were performed. on ... | 2002 | 12035946 |
| reflex choroidal blood flow responses of the eyeball following somatic sensory stimulation in rats. | the effect of cutaneous mechanical stimulation on choroidal blood flow (chbf) of the eyeball measured using a laser doppler flowmeter was examined in anesthetized rats. noxious pinching stimulation of a forepaw for 20 s produced increases in chbf and mean arterial blood pressure (map), whereas brushing of a forelimb produced no changes in either parameter. after spinal transection at the fourth thoracic (t4) level, forepaw pinching stimulation did not produce any map changes in 9 of 11 spinalize ... | 2002 | 12036184 |
| [canine panosteitis--an idiopathic bone disease investigated in the light of a new hypothesis concerning pathogenesis. part two: biochemical aspects and investigations]. | the pilot study included serum analysis of ionized calcium, copper, zinc, various hormones and amino acid profiles from dogs affected with panosteitis, as well as protein electrophoresis performed on bone biopsies. results of these analyses are as follows: ionized calcium, copper, zinc and hormones (parathyroid hormone, igf-1, t3 and t4) were within reference ranges. eleven of 23 serum amino acids from panosteitis-affected dogs were found to be significantly increased (p = 0.05). sds-polyacrylam ... | 2002 | 12038214 |
| leptin and thyroxine during sexual development in male monkeys: effect of neonatal gonadotropin-releasing hormone antagonist treatment and delayed puberty on the developmental pattern of leptin and thyroxine secretion. | neonatal treatment of male monkeys with a gonadotropin-releasing hormone antagonist (ant) increased the incidence of delayed puberty. using blood samples that had been collected from monkeys with normal or delayed puberty, we assessed the potential involvement of leptin and thyroxine (t4) in sexual development. | 2002 | 12039711 |
| salvage cryotherapy for recurrent prostate cancer after radiotherapy: variables affecting patient outcome. | to determine the long-term disease-specific survival (dss) and disease-free survival (dfs) rates after salvage cryotherapy for locally recurrent adenocarcinoma of the prostate and to identify pretreatment factors that have an impact on dss and dfs. | 2002 | 12039928 |
| oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: the di.n.a.s. randomized trial. | diabetic nephropathy may be effectively prevented and treated by controlling glycemia and administering angiotensin-converting enzyme (ace) inhibitors. however, strict metabolic control can be difficult, and ace inhibitors may be poorly tolerated and only partially effective, particularly in diabetes mellitus type 2 (dm2), warranting the search for ancillary treatment. sulodexide is a glycosaminoglycan, a new class of drug that has demonstrated nephroprotective activity in experimental investiga ... | 2002 | 12039991 |
| effects of chronic oral amiodarone on left ventricular function, ecgs, serum chemistries, and exercise tolerance in healthy dogs. | amiodarone, a class iii antiarrhythmic with beta-adrenergic blocking and antimuscarinic properties, has a wide spectrum of clinical use in humans. this study was conducted to establish the effects of a 25 mg/kg q12h loading dose and a 30 mg/kg q24h maintenance dose of amiodarone, each given po for 3.5 weeks, on systemic arterial pressure, echocardiographic (echo) indices of left ventricular function, ecgs, exercise tolerance, and serum biochemistries in adult, clinically normal dogs. means were ... | 2002 | 12041653 |
| [hypothalamic-pituitary-thyroid axis in depression]. | depressed patients, although viewed as chemically euthyroid, have alterations in the function of hypothalamic-pituitary-thyroid axis including slight elevation of the serum thyroxine (t4), loss of the nocturnal tsh rise, blunted thyrotropin (tsh) response to thyrotropin-releasing hormone (trh) stimulation and predisposition to autoimmune thyroiditis. both hypothyroid and depressed patients share a number of clinical features in common. this is the reason that some research workers use the "brain ... | 2002 | 12043045 |
| [non-small cell lung cancer (nsclc)]. | the goal of radiation therapy for non-small cell lung cancer (nsclc) is to improve the survival rate of patients without increasing treatment-related toxicity and to improve patients' quality of life. several prospective randomized trials have demonstrated a survival advantage in combined modality treatment over radiotherapy or chemotherapy alone when a cisplatin-based chemotherapy regimen is utilized in the treatment plan. combined modality treatment of cisplatin-based chemotherapy and radiothe ... | 2002 | 12043221 |
| bilateral breast cancer. | the aim of this study was to evaluate the clinical and pathological features of breast cancer patients with bilateral breast cancer and to assess the impact of the second breast cancer on their prognosis. thirty six breast cancer patients with bilateral (metasynchronous) cancer were treated in greatpoland cancer center from 1983 to 1995. it constituted 4.1% of all breast cancer patients treated in those years. 5-year survival rates were compared with clinical data (age, clinical stage, histologi ... | 2002 | 12044060 |
| importance of lymph node metastases in follicular thyroid cancer. | there are many concepts of risk and prognostic factor analysis for differentiated thyroid cancer. the prognostic role of lymph node metastases in follicular thyroid cancer (ftc), however, is still controversial. we performed a retrospective trial in 186 patients with ftc (124 women, 62 men; mean follow-up 5.5 years) questioning whether lymph node metastases and radical thyroid surgery with neck dissection contribute to the prognosis of ftc. univariate analysis demonstrated that lymph node metast ... | 2002 | 12045860 |
| tgf beta1 expression and angiogenesis in colorectal cancer tissue. | transforming growth factor tgf beta1 is involved in a variety of important cellular functions,including cell growth and differentiation, angiogenesis, immune function and extracellular matrix formation. however, the role of tgf beta(1) as an angiogenic factor in colorectal cancer is still unclear. we investigate the relationship between transforming growth factor beta(1) and angiogenesis by analyzing the expression of transforming growth factor tgf beta(1) in colorectal cancer, as well as its as ... | 2002 | 12046078 |
| influence of kappa-rhythm when assessing drowsiness. | kappa-rhythm appears at the highest amplitude on a bipolar t3-t4 derivation and its frequency range is 7-10 hz. when a contra-lateral earlobe is used as a reference, the kappa-rhythm causes serious problems in assessing drowsiness. assessment of drowsiness using contra- and ipsi-lateral earlobes as references in 129 subjects who showed kappa-rhythm was compared. drowsiness could be assessed properly in only 26% of subjects using the contra-lateral earlobe and in 90% of subjects using the ipsi-la ... | 2002 | 12047587 |
| superior vena cava resection with prosthetic replacement for non-small cell lung cancer: long-term results of a multicentric study. | superior vena cava (svc) resection with prosthetic replacement for non-small cell lung cancer (nsclc) is infrequently performed and oncological results are unclear. to establish a historical benchmark for this extended surgery, we have updated and reviewed data from four international centers. | 2002 | 12048089 |
| length of esophageal cancer and degree of luminal stenosis during upper endoscopy predict t stage by endoscopic ultrasound. | endoscopic ultrasonography (eus) is considered to be the most accurate modality for t staging of esophageal cancer. this study attempted to determine whether endoscopic features such as the length and degree of luminal stenosis in esophageal cancer can predict the t stage on eus. | 2002 | 12048628 |
| the influence of the root zone temperatures on the phytoextraction of boron and aluminium with potato plants growing in the field. | the effect of different root zone temperatures on the concentration and content of b and al in potato plants was examined using four different treatments of plastic mulches: t1: transparent polyethylene; t2: white polyethylene; t3: coextruded black and white polyethylene; t4: black polyethylene. an open-air treatment (t0) was used as control. the results showed significantly positive effects of the plastic covers on the root-zone temperatures: t0 = 16 degrees c, t1 = 20 degrees c, t2 = 23 degree ... | 2002 | 12049127 |
| a bipartite bacteriophage t4 soc and hoc randomized peptide display library: detection and analysis of phage t4 terminase (gp17) and late sigma factor (gp55) interaction. | hoc and soc are dispensable t4 capsid proteins that can be used for phage display of multiple copies of peptides and proteins. a bipartite phage t4 peptide library was created by displaying on tetra-alanine linker peptides five randomized amino acids from the carboxyl-terminus of soc and five randomized amino acids from the amino terminus of hoc. the bipartite library was biopanned against the phage t4 terminase large subunit gp17 to identify t4 gene products that may interact with the terminase ... | 2002 | 12051907 |
| structural differences in the noe-derived structure of g-t mismatched dna relative to normal dna are correlated with differences in (13)c relaxation-based internal dynamics. | detailed description of the characteristics of mismatched dna that are distinct from normal dna is vital to the understanding of how mismatch repair proteins are able to recognize and repair these dna lesions. to this end, we have used nuclear overhauser effect spectroscopy (noesy)-based distance restraints and (13)c relaxation measurements to solve the solution structures and measure some of the internal dynamics of the g-t mismatched dna oligomer d(ccatgcgtgg)(2) (gt) and its parent dna sequen ... | 2002 | 12051946 |
| heat capacity of folding of proteins corrected for disulfide cross-links. | the heat capacities (deltac(p,f)) for the temperature-induced folding of proteins: barnase, lysozyme t4, papain, trypsin, ribonuclease t1, chymotrypsin, lysozyme and ribonuclease a have been calculated from the change in solvent accessible surface area between the native state and extended polypeptide chain. to visualize the effect of disulfide cross-links on molar heat capacity, loops of varying number of alanine residues and extended alanine chains with terminal cystein are modeled. the differ ... | 2002 | 12052496 |
| significance of vitamin d receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in japanese. | recent studies have demonstrated an association between vitamin d receptor (vdr) genotype and prostate cancer. currently, there is a scarcity of data regarding the association of vdr genotype with benign prostatic hyperplasia (bph). the purpose of this study was to investigate the taqi vdr polymorphism in japanese prostate cancer patients, japanese bph patients and japanese controls in order to determine if an association exists between vdr genotype and the risk of developing prostate cancer and ... | 2002 | 12053022 |
| higher morbidity and mortality after combined total gastrectomy and pancreaticosplenectomy for gastric cancer. | total gastrectomy with pancreaticosplenectomy for gastric cancer has been proposed for facilitating lymph node dissection or for resection of direct tumor invasion to the pancreas, especially for t4 lesions. its effectiveness in improving patient survival is still controversial, and higher morbidity and mortality with this procedure have been reported in several series. such risks to patient survival were not observed in the japanese series. based on a prospective gastric cancer database maintai ... | 2002 | 12053218 |
| nonthyroidal illness syndrome: evaluation of thyroid function in sick patients. | altered thyroid function tests as a consequence of illness have been recognized for many years, yet the cause and clinical implications remains uncertain. the routine testing of thyroid function in hospitalized patients should be discouraged, as the results are less predictive of primary thyroid disease than in ambulatory patients. clinicians should be aware of the methods used for thyroid function testing, as the effect of illness on thyroid function varies among the different tests. the most c ... | 2002 | 12055987 |
| effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion. | obesity and starvation have opposing affects on normal physiology and are associated with adaptive changes in hormone secretion. the effects of obesity and starvation on thyroid hormone, gh, and cortisol secretion are summarized in table 1. although hypothyroidism is associated with some weight gain, surveys of obese individuals show that less than 10% are hypothyroid. discrepancies have been reported in some studies, but in untreated obesity, total and free t4, total and free t3, tsh levels, an ... | 2002 | 12055988 |
| p300 amplitude over temporal regions in schizophrenia. | to examine the left temporal scalp area reductions of p300 amplitude, event-related potentials (erps) during a standard oddball task were recorded in 57 schizophrenic patients and 33 normal controls. the p300 amplitude at t3 was not significantly smaller than that at t4 in schizophrenic patients. in the anova analysis of the p300 peak amplitude and pca factor scores, significant lateral topographical differences in p300 were not present between patients and controls. however, in schizophrenia, p ... | 2002 | 12056575 |