Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [techniques applicable to broncho-alveolar lavage fluid in hospital laboratory for the diagnosis of parasitic and fungal pneumopathies in immunosuppressed patients]. | parasitic and fungal organisms which are likely to cause pulmonary infections in immunosuppressed patients can be detected in broncho-alveolar fluid (bal fluid). single and standard methods, such as direct examination of the pellet, eosine-methylene blue fast (ral 555), cultures in usual mediums of mycology must be systematically applied to this sample and may help detect these organisms without further exploration. if the results are negative, more recent techniques can be used if they present ... | 1991 | 2064088 |
| pneumocystis carinii pneumonia: new approaches to diagnosis, treatment and prevention. | 1991 | 2067889 | |
| pneumocystis carinii pneumonia: effect of corticosteroid treatment on radiographic appearance in a patient with aids. | dramatic radiographic and clinical resolution of pneumocystis carinii pneumonia occurred in a patient with acquired immunodeficiency syndrome after corticosteroids were added to his standard antimicrobial treatment regimen. no cause other than p carinii infection could be demonstrated for the patient's pulmonary disease, and his clinical and radiographic abnormalities waxed and waned in synchrony with decreases and increases in his dose of corticosteroids. | 1991 | 2068305 |
| pneumocystis carinii is rare in aids in central africa. | pneumocystis carinii occurs in 60-65% of cases of acquired immunodeficiency syndrome (aids) in europe and north america. its prevalence in africa is unknown, however, due to a lack of suitable investigative techniques. initial studies suggest that this parasitic complication may be lower in africa. an investigation of aids case in harare, zimbabwe, revealed pneumocystosis in only 22%. reported here are the results of a study of 45 congolese patients with aids conducted at the brazzavile universi ... | 1991 | 2068770 |
| pneumocystis carinii pneumonia after heart transplantation. | five patients with pneumocystis carinii pneumonia after heart transplantation are reported. four had severe clinical symptoms, whereas 1 was asymptomatic. mechanical ventilatory support was necessary in 1 because of respiratory distress. pneumocystis carinii infection developed in 4 patients within the first 4 postoperative months, and 1 patient had clinical disease 1 year after transplantation with a recurrence 9 months later. all were treated with trimethoprim-sulfamethoxazole either orally or ... | 1991 | 2069436 |
| [pathomorphology of experimental pneumocystosis and cytogenesis of the pathogen pneumocystis carinii]. | a lung pneumocystosis model has been developed in white non-inbred rats (83 animals). the pathological process develops during 1 month versus 2-3 months in other models. pathomorphology is in principle similar to human pneumocystosis. bauer's method appeared to be the simplest and adequate for the detection of mature pneumocysts in the lung sections among many other methods used. | 1991 | 2069524 |
| pneumocystis carinii, an opportunist in immunocompromised patients. | pneumocystis carinii has been recognized as a cause of pneumonia in immunocompromised patients for over 40 years. until the 1980s, pneumocystis pneumonia (pneumocystosis) was most often seen in patients undergoing chemotherapy for malignancy or transplantation. infection could be prevented by trimethoprim-sulfamethoxazole prophylaxis; thus, it was an uncommon clinical problem. with the onset of the aids epidemic, pneumocystis pneumonia has become a major problem in the united states because it d ... | 1991 | 2070342 |
| optimising technetium 99m diethylene triamine penta-acetate lung clearance in patients with the acquired immunodeficiency syndrome. | pneumocystis carinii pneumonia (pcp) has become a major cause of morbidity and mortality due to infectious diseases, largely as a result of the acquired immunodeficiency syndrome (aids) epidemic. since the mortality from recurrent infection is between 40% and 60%, early diagnosis and therapy are the keys to survival. the role of technetium 99m diethylene triamine penta-acetate (dtpa) aerosol pulmonary clearance was studied in 81 patients with aids. the mathematical technique of curve stripping w ... | 1991 | 2070802 |
| adult respiratory distress syndrome complicating pneumocystis carinii pneumonia. | 1991 | 2071131 | |
| cost differentials in the treatment of pneumocystis carinii pneumonia. | 1991 | 2071913 | |
| [ultrasonic nebulised pentamidine for pneumocystis carinii pneumonia]. | our retrospective study for ultrasonic nebulised pentamidine in 13 patients shows that 7 of 8 patients with pneumocystis carinii pneumonia (pcp), proven by biopsy examination, were cured (recovery rate, 88%). two of these 8 patients were mainly treated by nebulised pentamidine and the other 5 patients were administered parenteral pentamidine before the nebulised pentamidine therapy and the final 1 patient died on day 9 without clinical improvement with nebulised pentamidine as well as convention ... | 1991 | 2071948 |
| pneumocystis carinii pneumonia in simian immunodeficiency virus infection: immunohistological and scanning and transmission electron microscopical studies. | pneumocystis carinii pneumonia occurred in 6 of 17 rhesus monkeys infected with simian immunodeficiency virus and was studied by immunohistochemistry and by scanning and transmission electron microscopy. a monoclonal antibody/streptavidin-biotin-peroxidase staining method was highly sensitive for detecting the organisms in small, early lesions and was much more sensitive and specific than traditional silver impregnation methods. reprocessing of paraffin wax-embedded lung tissue for scanning elec ... | 1991 | 2072217 |
| [multiple pitted nodule images in aids. apropos of a case]. | a new semiological aspect of pneumocystis carinii pneumonia is reported in an aids patient. this pneumopathie is unusual because of its pitted nodules and its occurrence in a patient under prophylactic aerosol pentamidine therapy. | 1991 | 2072343 |
| [digestive manifestations and metabolic acidosis secondary to intravenous administration of cotrimoxazol]. | digestive features and metabolic acidosis have been observed in patients with pneumocystis carinii pneumonia treated with intravenous high dose co-trimoxazole. | 1991 | 2072774 |
| [kaposi's sarcoma with primary pulmonary involvement in a parenteral drug addict with acquired immunodeficiency syndrome]. | pulmonary kaposi's sarcoma (ks) was diagnosed by pulmonary biopsy in a heterosexual parenteral drug abuser (pda). the patient had previously been diagnosed of pneumocystis carinii pneumonia and pulmonary tuberculosis. thoracic computed tomography (ct) showed bilateral nodular lesions which were less apparent in conventional radiological study and which increased in size in spite of correct therapy. as cutaneous lesions suggesting ks subsequently appeared, the possibility of pulmonary ks was cons ... | 1991 | 2072777 |
| in-vitro interaction of human macrophages with pneumocystis carinii. | pneumocystis carinii is an important opportunistic pathogen in patients with compromised cell-mediated immunity. t-cell and macrophage function are believed to be of prime importance in defence against this organism. the present ultrastructural study is aimed at the analysis of the interaction between human macrophages and p. carinii in vitro. adherent peripheral blood mononuclear cells from healthy volunteers were exposed in vitro to pneumocystis derived from lungs of steroid-treated rats. the ... | 1991 | 1742212 |
| recombinant human granulocyte-macrophage colony-stimulating factor ameliorates zidovudine-induced neutropenia in patients with acquired immunodeficiency syndrome (aids)/aids-related complex. | to evaluate the effect of recombinant granulocyte-macrophage colony-stimulating factor (gm-csf) on patients with acquired immunodeficiency syndrome (aids) or aids-related complex (arc) who were intolerant to zidovudine because of neutropenia, we performed a randomized, open-label study in which patients were assigned to one of two groups. zidovudine was discontinued in group a patients before instituting gm-csf treatment and was restarted in a graduated fashion over 4 weeks. group b patients con ... | 1991 | 1742482 |
| scintigraphic distribution of pneumocystis carinii pneumonia in aids treated with prophylactic inhaled pentamidine. | 1991 | 1742934 | |
| growth and metabolism of pneumocystis carinii in axenic culture. | 1991 | 1742950 | |
| cutaneous ulceration: an unusual complication of intravenous pentamidine therapy. | pentamidine is one of two agents currently used to treat infections with pneumocystis carinii. the intramuscular route of administration is associated with cutaneous side effects such as dermal necrosis, sterile abscesses and ulcer formation at the injection site, while urticaria may develop near the site of intravenous drug infusion. this is a report of a renal transplant patient with pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intraven ... | 1991 | 1743388 |
| [pulmonary scintigraphy with gallium-67 in the early detection of pneumocystis carinii pneumonia]. | 1991 | 1745091 | |
| impact of treatment guidelines on the use of aerosolized pentamidine for prevention of pneumocystis carinii pneumonia. | 1991 | 1746581 | |
| blastomycosis and opportunistic infections in patients with acquired immunodeficiency syndrome. an autopsy study. | patients with acquired immunodeficiency syndrome (aids) are subject to a host of opportunistic infections, but to our knowledge a predisposition to blastomycosis has not previously been established. autopsies of two patients with aids revealed disseminated blastomycosis with massive pulmonary involvement, blastomyces meningoencephalitis, and widespread dissemination. the massive systemic involvement and rapid terminal course in both cases may reflect the state of acquired immunodeficiency. an an ... | 1991 | 1747031 |
| disseminated pneumocystosis without pulmonary involvement during prophylactic aerosolized pentamidine therapy in a patient with the acquired immunodeficiency syndrome. | pneumocystosis, the most common opportunistic infection associated with the acquired immunodeficiency syndrome, is usually restricted to the lungs and results in severe bilateral pneumonia, which is fatal unless vigorously treated. rare cases have been reported in which involvement of other organs or disseminated disease occurred in addition to the pulmonary lesions. pentamidine, an efficient drug used intravenously for the treatment of pulmonary pneumocystosis, has also recently been used in ae ... | 1991 | 1747032 |
| pneumocystis carinii pneumonia causing hypertrophic osteoarthropathy. | 1991 | 1747709 | |
| a pilot study of epirubicin and chlorambucil in the treatment of chronic lymphocytic leukemia (cll). | in a pilot study of the combination of epirubicin and chlorambucil in the treatment of chronic lymphocytic leukemia (cll), 10 patients with advanced or progressive disease were treated in four centres. up to a total of 15 courses in individual patients were given. toxicity was relatively mild with nausea due to epirubicin being the most commonly reported side-effect. one patient developed a probable septicemia during a period of neutropenia. in another patient who died from probable pneumocystis ... | 1991 | 1748398 |
| trimethoprim-sulfamethoxazole. | the antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against various gram-positive and gram-negative bacteria. clinically, it is useful for prophylaxis and treatment of selected infections of the genitourinary, respiratory, and gastrointestinal tracts. trimethoprim-sulfamethoxazole by itself or in combination with other antimicrobial agents is indicated for most nocardia asteroides infections and is the antimicrobial agent of choice for pneumocystis carinii pneum ... | 1991 | 1749295 |
| diagnostic value of lung clearance of 99mtc dtpa compared with other non-invasive investigations in pneumocystis carinii pneumonia in aids. | various non-invasive investigations were carried out in patients infected with hiv who had respiratory symptoms with and without pneumocystis pneumonia (with pneumonia, n = 13 (five smokers); without pneumonia, n = 22 (13 smokers]. these included chest radiography; lung function tests (forced expiratory volume in one second, forced vital capacity; transfer factor and coefficient for carbon monoxide); arterial blood gas tensions; arterial oxygen saturation at rest and on exercise; and lung cleara ... | 1991 | 1750019 |
| cpap, effective respiratory support in patients with aids-related pneumocystis carinii pneumonia. | human immunodeficiency virus (hiv) related pneumocystis carinii pneumonia (pcp) associated with severe respiratory failure is an increasingly common problem in major centres and is associated with a high mortality in previous and recent studies. early in the epidemic, alternatives to invasive intensive care treatment were utilized in our institution and found to be successful. when respiratory failure developed, mask cpap was used instead of intubation and ventilation. a retrospective review of ... | 1991 | 1750639 |
| pulmonary nocardiosis concurrent with pneumocystis carinii pneumonia in two patients undergoing immunosuppressive therapy. | two cases with concomitant pulmonary nocardiosis and pneumocystis carinii pneumonia are described. the first patient developed pneumonia 3 months after heart transplantation while undergoing standard immunosuppressive therapy with cyclosporin, azathioprine and prednisone. the second patient was treated with chemotherapy and subsequent radiotherapy of the mediastinum for a malignant epithelial tumour. he also received prednisone for paraneoplastic dermatomyositis. chest x-rays of both patients sh ... | 1991 | 1753118 |
| pediatric hiv infection. an update. | human immunodeficiency virus infection is a leading cause of immunodeficiency in children. the epidemic in children parallels that in women since most infected women are in the child-bearing age groups. the risk of vertical transmission of hiv from an infected mother to her infant ranges from 13% to 39%. diagnosis of infection in the infant is complicated by the passive transfer of antibody across the placenta, making the use of standard serologic tests to confirm infection difficult. in childre ... | 1991 | 1753232 |
| [the effect of inhaled pentamidine in the radiology of pneumocystis carinii pneumonia]. | 1991 | 1753825 | |
| microculture screening assay for primary in vitro evaluation of drugs against pneumocystis carinii. | pneumocystis carinii inoculated into 96-well filtration plate assemblies was shown to synthesize radiolabeled folates de novo from [para-3h]aminobenzoic acid ([3h]paba). at the end of each incubation with [3h]paba, a vacuum manifold was used to remove the medium and wash p. carinii. the membrane at the base of each well was dried and punched out, and the level of 3h retained was determined by direct scintillation counting. high-pressure liquid chromatography analysis of duplicate filters confirm ... | 1991 | 1759815 |
| cellular and molecular biology of pneumocystis carinii. | 1991 | 1761385 | |
| severe combined immune deficiency presenting with cyclic hematopoiesis. | at age 2 months a male infant presented with a cyclic clinical syndrome every 14-21 days that included pharyngeal aphthous ulcers, high fever, lymphadenopathy, pallor, and malaise. serial blood studies indicated cycling of all blood cell elements, compatible with a diagnosis of cyclic hematopoiesis (ch). he also manifested a progressively severe immune deficiency, not described before in human ch. when first studied at age 5 months, he was hypogammaglobulinaemic with normal b lymphocyte numbers. ... | 1991 | 1761643 |
| opportunistic parasitic infections in immunocompromised hosts. | parasitological and serological examination was done for 111 cases with various types of malignancies under immunosuppressive therapy and another 20 apparently healthy individuals as a control group to determine the prevalence of opportunistic parasitic infections among immunocompromised patients. single examination showed that 74 (66.7%) harboured infection with different parasites: strongyloides stercoralis infection was found in 4 (3.64%) cases; 3 cases (2.7%) had pneumocystis carinii infecti ... | 1991 | 1765676 |
| correlation between the level of iga and pneumocystis carinii infection. | sputum examination for detection of p. carinii pneumonia (pcp) can be substituted for more invasive techniques. there was a significant correlation between pcp and the increased level of iga in serum (p less than 0.01) and sputum. the increase in iga level in sputum was much more higher than that in the serum. this supports the concept that local antibody formation by the lung may have a more important role in the immune and inflammatory response to p. carinii. | 1991 | 1765690 |
| lung cavities from pneumocystis carinii in a patient with systemic lupus erythematosus. | a patient with sle developed pneumonia due to pneumocystis carinii. the unusual presentation was the multiple lung cavities. there appeared to be a temporal relationship between the lung infection and reducing steroid intake in this patient. | 1991 | 1765749 |
| pneumocystis carinii pneumonia in a human immunodeficiency virus 1-infected neonate with meconium aspiration. | 1991 | 1766715 | |
| a simple method of separation of pneumocystis carinii from rat lung. | existing methods for purification of pneumocystis carinii are unsatisfactory. dialysis is a simple, non-stressful treatment which aided purification of organisms from rat cells. yields were quantitated using a petroff-hausser chamber and nuclear staining. following dialysis overnight, three times the yields of similar, undialysed preparations were obtained, with less than 0.2% contamination by lung cells. overnight incubation at 4 degrees c also improved separation, but yields were only half tho ... | 1991 | 1768612 |
| pneumocystis carinii in fna of the thyroid. | we report the diagnosis of pneumocystis carinii (pc) in a fine-needle aspirate (fna) from the thyroid of a human immunodeficiency virus infected (hiv+) male receiving aerosolized pentamidine as prophylaxis for pneumocystis carinii pneumonia (pcp). the clinical diagnosis prior to fna was multinodular goiter. the patient did not have pulmonary symptoms nor previous diagnosis of pcp at the time of the aspirate diagnosis. recently, extrapulmonary pneumocystis carinii (epc) has been reported with inc ... | 1991 | 1769291 |
| ["i don't see medical reasons for a change". dr. h. busch, münster, takes a position on prevention of pneumocystis carinii pneumonia with pentamidine aerosol. interview by wilma mahler]. | 1991 | 1769644 | |
| detection of pneumocystis carinii sequences by polymerase chain reaction: animal models and clinical application to noninvasive specimens. | pneumocystis carinii is a eukaryotic microbe which causes fatal pneumonia in patients with aids. oligonucleotide primers were used to amplify the 5s rdna sequence of p. carinii by the polymerase chain reaction (pcr) in various clinical and animal samples. of 35 independent lung specimens tested, pcr detected the p. carinii sequence in all 23 cases which were known to be p. carinii infected, i.e., 15 from mice, 1 from rat, 3 from human autopsy, and 4 from biopsy of aids patients by needle aspirat ... | 1991 | 1774325 |
| [lung diseases and treatment with methotrexate in rheumatoid arthritis]. | methotrexate (mtx) is used as sequential treatment of rheumatoid arthritis in doses ranging from 5 to 20 mg per week, but its effectiveness is impaired by undesirable and sometimes severe side-effects, notably on the lungs. we report three cases of lung disease in patients with rheumatoid arthritis under mtx therapy. two patients had a lung infection caused by escherichia coli and pneumocystis carinii respectively and the third patient was a case of fatal pneumonia imputed to mtx. the signs and ... | 1991 | 1775874 |
| trimethoprim-sulfamethoxazole reaction simulating pneumocystis carinii pneumonia. | 1991 | 1777163 | |
| transmission of pneumocystis carinii from aids patients to other immunosuppressed patients: a cluster of pneumocystis carinii pneumonia in renal transplant recipients. | five renal transplant recipients developed pneumocystis carinii pneumonia (pcp) over a 22-month period, while no cases had been observed over a 5-year period in 114 transplanted patients treated with the same immunosuppressive protocol. all patients were hiv-negative, and no modification in diagnostic techniques for p. carinii could account for this observation. all five patients developed pcp within 2 months of an acute graft rejection episode. all of them attended the same outpatient facility ... | 1991 | 1777173 |
| latent haemophilus influenzae pneumonia in patients infected with hiv. | pneumonia caused by common pyogenic bacteria occurs frequently in hiv-infected patients. its clinical presentation has been described as being similar to that seen in non-immunosuppressed hosts but clearly different to that of opportunistic pneumonias. an atypical presentation has rarely been seen. in a 10-month period, we saw 12 hiv-infected patients who presented with haemophilus influenzae pneumonia which was clinically and radiologically indistinguishable from pneumocystis carinii pneumonia. ... | 1991 | 1777177 |
| [the radiological pictures of pulmonary tuberculosis in hiv+ patients]. | mycobacterial infections can be found in 10% of aids patients. seventy cases with hiv+ infection were examined: they exhibited clear alterations of the chest and contemporaneous isolation and identification of mycobacteria. primary tuberculosis is the most frequent manifestation in these patients. alveolar parenchymal mono/bilateral infiltrates are the radiographic patterns of this pulmonary condition; they usually present without excavation (45.7%). hilar and/or mediastinal lymph nodes are usua ... | 1991 | 1780458 |
| [inadequate adh secretion syndrome associated with acquired immunodeficiency syndrome]. | within the numerous complications of aids, we want to point out the appearance of inadequate adh secretion syndrome (iadhss) in 9 out of; patients, which constitutes a higher percentage than in the general population. in all cases iadhss was associated to lung or central nervous system pathology. in one patient, iadhss preceded the appearance pneumocystis carinii pneumonitis. therefore, if hyponatremia is founding aids patients, the existence of adrenal pathology or iadhss should be suspected. | 1991 | 1780508 |
| admission for hiv-1 related disease in a dublin hospital 1987-1990. | between january 1987 and december 1990, 179 patients (131 men, 48 women) infected with human immunodeficiency virus type 1 (hiv-1) were admitted 408 times to st james's hospital, dublin. one hundred and thirty-two (73.7%) patients were intravenous drug users. the commonest cause of admission was bacterial lower respiratory tract infection (84 patients, 21%). at the time of study 95 (53%) patients fulfilled centers for disease control (cdc) criteria for stage iv disease. hiv antibody status in 26 ... | 1991 | 1782235 |
| [pneumocystis carinii pneumonia]. | we present twelve cases of pneumocystis carinii pneumonia (pcp) hospitalized at the internal medicine service of the hospital clínico de valencia between 1989 and 1990. all patients were infected by hiv-1, with ages between 25 and 32 years, with circulating cd4 lymphocytes lower than 25% or 200 cells per cubic millimeter and with positive p24 antigen. ten of them were parenterally drug addicts and two of them, homosexuals. diagnosis was made by fibrobronchoscopy (fb) with bronchoaspiration (bas) ... | 1991 | 1782311 |
| pharmacokinetic justification of antiprotozoal therapy. a us perspective. | infections with parasitic protozoa have always been problems for the developing world and are becoming of greater importance to the developed world in this age of easy international travel. the major human protozoal diseases are summarised with an emphasis on their presentation in normal hosts and in immunocompromised individuals and current us drug treatment recommendations are discussed. present antiprotozoal regimens are based either on a pharmacokinetic rationale or on clinical trial and err ... | 1991 | 1782741 |
| histone preopsonisation increases the respiratory burst response of phagocytes to pneumocystis carinii. | preincubation of pneumocystis carinii with histone caused an increase in polymorphonuclear leucocyte and macrophage chemiluminescence when parasites were mixed with phagocytes compared with that obtained when unopsonised parasites were used. toxic oxygen moieties released during the respiratory burst may cause tissue damage. | 1991 | 1783287 |
| [cryptosporidium diarrhea developing in two japanese adults--one in aids and the other in a normal host. research group for infectious enteric diseases, japan]. | case i: a middle-age homosexual male developed aids with pneumocystis carinii pneumonia (pcp) and esophageal candidiasis in 1986 during his stay in an european country about five months prior to transfer to tokyo metropolitan komagome hospital, tokyo, in 1987. he was also diagnosed as having cryptosporidiosis presenting with mild diarrhea a month following the diagnosis of pcp. diarrhea was successfully treated with spiramycin. on transfer to tokyo metropolitan komagome hospital, he was febrile ... | 1991 | 1783813 |
| three-dimensional reconstruction of rabbit-derived pneumocystis carinii from serial-thin sections. i: trophozoite. | the highly complex ultrastructural morphology of the endomembrane system in pneumocystis carinii led us to perform three-dimensional reconstruction from serial-thin sections using the catia (conception assistée tridimensionnelle inter active) dassault system program. the three-dimensional reconstruction of a small trophozoite made it possible to better understand the morphological relationship among organelles and to suggest cytophysiological hypotheses. by reconstructing other parasite stages, ... | 1991 | 1787425 |
| three-dimensional reconstruction of rabbit-derived pneumocystis carinii from serial-thin sections. ii: intermediate precyst. | three-dimensional reconstruction of a binucleate intermediate precyst of pneumocystis carinii was performed from serial-thin sections using the catia (conception assistée tridimensionnelle inter active) dassault system program. the presence of a mitochondrion, complex well-developed endoplasmic structures, and numerous golgi vesicles was established. a better understanding of the ultrastructure of rabbit-derived p. carinii stages made it possible to formulate hypotheses on the evolution and phys ... | 1991 | 1787426 |
| glucan synthesis in pneumocystis carinii. | rat-derived pneumocystis carinii lysed with sodium deoxycholate catalysed the incorporation of uridine diphosphoglucose into an insoluble polymer. this enzyme activity was present in both the pellet and the supernatant when the p. carinii preparations were centrifuged. the polymer whose production was catalysed by the supernatant was examined by mass spectrometry and found to be an alpha 1----4 glucan, which is either unbranched or has relatively few branches. polymer formation was completely in ... | 1991 | 1787429 |
| pneumocystis carinii pneumonia: detection of parasites by immunofluorescence based on a monoclonal antibody. | a monoclonal antibody-based immunofluorescence test for the detection of pneumocystis carinii was evaluated in comparison with the conventional direct staining by grocott's silver methenamine technique. a total of 254 respiratory samples from hiv positive and other immunocompromised patients were examined. cysts were detected in 30 (12%) of samples using the monoclonal test, but only 15 (6%) positives were found using the grocott method. there is need for a speedy and efficient test for detectio ... | 1991 | 1787784 |
| [polymyositis as the first manifestation of acquired immunodeficiency syndrome]. | we present a case of polymyositis (pm) in a patient with no previous relevant medical history, who had received blood transfusion four years ago during surgery. it could be demonstrated that the patient was hiv infected inspite the fact that he did not belong to any other high risk groups. pm was the clinical presentation form of hiv infection, the patient dying five months later due to a pneumocystis carinii. the main clinical and histologic characteristics of pm in hiv infected patients are de ... | 1991 | 1788459 |
| [bilateral pneumothorax in a patient with aids and pneumocystis carinii pneumonia]. | 1991 | 1788466 | |
| [the biological characteristics of pneumocystis carinii]. | 1991 | 1789040 | |
| pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma. | a 32 year old man with chronic severe asthma, requiring maintenance oral corticosteroids, was started on a weekly dose of methotrexate. eleven weeks later he developed pneumocystis carinii pneumonia. in the two years following treatment there has been no recurrence while oral corticosteroid treatment has been continued. pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia. | 1991 | 1792646 |
| autoradiographic examination of the organ distribution of 14c-labelled pentamidine in rats after intravenous and inhaled administration. | the organ distribution of 14c pentamidine was studied in sprague dawley rats by means of whole-body autoradiography following intravenous and inhaled application of pentamidine (pentacarinat, cas 140-64-7). the distribution time after intravenous administration of 5 mg pentamidine per kg rat was 30 min, 6 h, 24 h, and 7 days, respectively. the corresponding times after administration of aerosolized pentamidine were 30 min and 24 h. the distribution of radioactivity was also determined by measuri ... | 1991 | 1796921 |
| effect of surfactant replacement on pneumocystis carinii pneumonia in rats. | the effect of intratracheal surfactant instillation on pulmonary function in rats with pneumocystis carinii pneumonia (pcp) was investigated. in those animals which developed pcp with severe respiratory failure after administration of cortisone acetate s.c. over 8-12 weeks, pulmonary function was improved by surfactant instillation. pao2 values 30 min after surfactant instillation were significantly higher compared to pretreatment values and also compared to pao2 values of rats 30 min after rece ... | 1991 | 1797892 |
| three cases of acquired immunodeficiency syndrome complicated with toxic epidermal necrolysis. | co-trimoxazole (trimethoprim-sulfamethoxazole) and pyrimethamine-sulfadoxine have been recommended for treatment and prophylaxis, respectively, of pneumocystis carinii pneumonia (pcp). however, toxic epidermal necrolysis (ten) occurred in three of four patients with acquired immunodeficiency syndrome (aids) during the course of treatment or prophylaxis of pcp with these agents. on the other hand, 14 patients with pcp treated with pentamidine never developed ten. because the incidence of adverse ... | 1991 | 1798215 |
| [adverse effects of cotrimoxazole in spanish patients with aids and pneumonia caused by pneumocystis carinii]. | we retrospectively analyze the untoward effects due to cotrimoxazole (cmx) when this drug was used as initial therapy in 37 spanish aids patients with pneumocystis carinii pneumonia (pcp). a total of 46% of patients developed an adverse reaction, that was considered severe in 24.3% of cases, and prompted to stop cmx therapy in 10.8% of patients. the most frequent untoward effects were low white blood cells count (29.7%), skin rash (16.2%) and low platelet count (13.5%). the overall compliance an ... | 1991 | 1799610 |
| [advances in the diagnosis pneumocystis carinii pneumonia]. | 1991 | 1802443 | |
| [pneumocystis carinii pneumonia as a manifestations of aids]. | 1991 | 1803144 | |
| spontaneous remission of acute myeloid leukemia in a patient with concurrent pneumocystis carinii pneumonia. | we present a case of acute myeloid leukemia which went into complete remission during the course of concurrent interstitial pneumonia caused by pneumocystis carinii. as no antileukemic, cytostatic chemotherapy had been given, it is assumed that the infection played a major role in inducing this remission, which was however of only 6 months duration. brief reference is made to the literature concerning the effects of infections on the course of leukemia. | 1991 | 1803326 |
| serologic response to pneumocystis carinii of seoul national university hospital patients. | a total of 2,580 sera of the patients who were consulted to the serology laboratory of the seoul national university hospital were collected in 1990. the sera were screened by micro-elisa to detect igg antibody reacting with pneumocystis carinii antigen. the absorbances were 0.00 to 1.41 and mean 0.27 +/- 0.253. as the positive criterion was set absorbance 0.2 or more with 70% sensitivity, total positive rate was 44.4%. mean absorbances and positive rates were higher in children than in adults; ... | 1991 | 1804299 |
| [aids and myopathy: report of a case and review of the literature]. | report of an unusual case of myopathy in an hiv infected patient, responsive only to the immunosuppressor drug methotrexate. the patient was a 39 year old homosexual male with no past history of hiv-related manifestations. one month prior to admission he noticed that his left thigh was swollen and painful. two weeks later both arms became enlarged and tender. a few days before admission he noticed intermittent fever and progressive dyspnea. upon admission, oral thrush, dyspnea and global enlarge ... | 1991 | 1807240 |
| nurses' perspectives on problems of hospitalized pcp patients: implications for the development of a nursing taxonomy. | the phenomena of interest in nursing informatics research are the data, information and knowledge related to nursing. this study presents nurses' perspectives on the problems of patients hospitalized for pneumocystis carinii pneumonia from four data sources: nurse interview, intershift report, care plan, and nurses' notes. even within this narrowly specified sample, patient problems showed variation across sources of data. the results of this study demonstrate the difficulties inherent in develo ... | 1991 | 1807582 |
| [clinicopathologic study of various lung diseases with bronchiolitis obliterans organizing pneumonia (boop) pattern in open lung biopsy]. | the histologic findings of boop are nonspecific, and the diagnosis of idiopathic boop is one of exclusion. we studied the clinicopathologic features of various lung diseases with histopathological appearance of bronchiolitis obliterans organizing pneumonia (boop) pattern in open lung biopsy specimens. the 17 patients with boop pattern studied included idiopathic boop (n = 7), unclassified interstitial pneumonia (n = 1), collagen vascular disease (n = 3, ra 1, pm/dm 2), hypersensitivity pneumonit ... | 1991 | 1808381 |
| dissemination of pneumocystis carinii in patients with aids. | extrapulmonary pneumocystis carinii infections in aids are still rare although the number of cases is increasing. we present 2 cases of extrapulmonary pneumocystosis detected at our institution during an 8-month period. the first was a patient treated for p. carinii pneumonia (pcp) disseminated to liver, spleen and kidneys. the second patient had widely dissemination of p. carinii diagnosed at autopsy. both patients had received aerosolised pentamidine (ap) for pcp prophylaxis. totally we have t ... | 1991 | 1815330 |
| cerebral toxoplasmosis in danish aids patients. | we estimate the frequency of central nervous system (cns) toxoplasmosis in danish aids patients and evaluate the diagnostic accuracy using the following criteria for acceptance of the diagnosis: either (1) the demonstration of toxoplasma gondii in brain tissue or (2) one or more hypodense or ring-enhancing lesions on computerized axial tomography (cat) scan and a neurologic and cat scan improvement in response to 2 weeks of treatment. from 1981 until july 1990 266 patients were diagnosed with ai ... | 1991 | 1815332 |
| the neutrophil chemiluminescence response to pneumocystis carinii is stimulated by gm-csf and gamma interferon. | the interaction of pneumocystis carinii purified from rat lung with human polymorphonuclear leukocytes (pmn) was studied using amplified chemiluminescence. pre-incubation of pmn with granulocyte-macrophage stimulating factor or gamma interferon resulted in phagocyte stimulation. | 1991 | 1815709 |
| pneumocystis carinii pleuropneumonia after aerosolized pentamidine prophylaxis. | we observed an atypical pneumocystis infection with spontaneous pneumothorax, bronchopleural fistulae, an apical cyst and pneumocystis pleuritis after aerosolized pentamidine prophylaxis in an aids patient. these findings suggest a failure of pentamidine aerosol in controlling active pneumocystis infection in peripheral pulmonary areas. a relapse of pneumocystis carinii pneumonia (pcp) must be suspected when pneumothorax occurs during secondary prophylaxis with aerosolized pentamidine. it should ... | 1991 | 1816116 |
| nebulized pentamidine as prophylaxis for pneumocystis carinii pneumonia. | 1991 | 1817486 | |
| isolation and characterization of rat lung pneumocystis carinii gp120. | the principal glycoprotein (gp120) of pneumocystis carinii obtained from infected rat lung was isolated by differential extraction and size-exclusion chromatography. the purified glycoprotein was cleaved with cnbr to two peptides of approximately 27 and 33 kda. amino acid sequences were obtained from both peptides. proteolytic digestion with v8 protease yielded several peptides and sequences were obtained from peptides of 10 and 19 kda. the cyanogen bromide cleavage results led to the conclusion ... | 1991 | 1818123 |
| attempts at in vitro cultivation of pneumocystis carinii from human bronchoalveolar lavage fluids without feeder cells. | we attempted to cultivate pneumocystis carinii obtained from two bronchoalveolar lavage fluids of aids patients with p. carinii pneumonia, in a system wherein cysteine and 2-mercaptoethanol were substituted for the feeder cells. the presence of p. carinii cysts was monitored for 11 days under conditions of continuous culture. moderate increase in cyst forms was observed until day 11. further study with this system would be required to determine if the observed increase in cyst numbers is reprodu ... | 1991 | 1818129 |
| morphologic and biochemical studies of chitin expression in pneumocystis carinii. | tomato lectin, which binds oligosaccharides of n-acetyl-d-glucosamine, and an antiserum against macromolecular chitin were used to probe sections of human and murine lungs infected with pneumocystis carinii. by light, fluorescence and electron microscopy, lectin and antiserum binding patterns indicated that both human and murine strains of p. carinii express chitin at all identifiable stages of their life cycles. light microscopic autoradiographs of murine p. carinii cultured in vitro with 3h-gl ... | 1991 | 1818131 |
| overview of animal models of pneumocystis carinii pneumonia. | 1991 | 1818132 | |
| introduction of pneumocystis carinii in a colony of scid mice. | pneumocystis carinii-free scid mice were housed closely exposed to corticosteroid-treated non-scid mice in a conventional area of our laboratory animal facilities. a one-day exposure was sufficient for p. carinii transmission. the lung infection increased thereafter. irradiation or splenectomy of scid mice at the beginning of the exposure resulted in a marked increase of parasite multiplication. extrapulmonary foci of pneumocystosis were detected in heart and spleen of scid mice infected by p. c ... | 1991 | 1818133 |
| establishment of pneumocystis carinii in various mouse strains using natural transmission to initiate infection. | a mouse model for pneumocystis carinii has now been established in several strains of mice: c3heb/fej, c3hen, balb/c, dba/2n and athymic. in lieu of using invasive methods for initiating p. carinii infections, mice infected with p. carinii (seed mice) transmitted the disease to mice without latent infection via short term co-habitation. acute infections in recipient mice developed approximately 5-6 wk after c3heb/fej seeds were removed, while control unseeded litter-mates remained uninfected. th ... | 1991 | 1818134 |
| pneumocystis carinii--animal production perspective. | pneumocystis carinii is an important cause of pneumonia in immunocompromised human patients. the organism is also found as a saprophyte in the lungs of many species of animals. animal models have been used as a source of p. carinii organisms for study of the disease. the rat model has been especially useful. initially, the infection was latent in most colonies, and p. carinii pneumonia readily developed when animals were immunosuppressed. today, many barrier raised rodent colonies are free of ad ... | 1991 | 1818135 |
| inoculated mouse model of pneumocystis carinii pneumonia. | a transtracheally inoculated mouse model of pneumocystis carinii has been developed using balb/c mice, a widely available strain free of latent p. carinii infection. the mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. an inoculated mouse model of p. carinii infection provides both a source of organisms from a different host and a ... | 1991 | 1818136 |
| a review of common infectious disease agents of laboratory mice and rats: potential influence on pneumocystis carinii. | the influence of viruses and bacteria on pneumocystis carinii pneumonia (pcp) is suspected but not known for certain. a number of adventitious viruses and bacteria are common among commercially available and institutionally raised rodents, which may impact upon, or interfere with, the induction of pcp in rodents in several ways. based upon the biological behavior and prevalence of certain rodent agents, the potential for such impact is great. infectious agents can directly interfere with researc ... | 1991 | 1818137 |
| pneumocystis carinii pneumonia in the rat model. | groups of barrier-raised but not certified virus-free sprague-dawley rats, obtained from the same source over the course of several years, were placed on an identical immunosuppressive regimen. this caused reactivation of latent pneumocystis carinii infection, manifest as p. carinii pneumonia (pcp) of varying severity. rats were euthanized after 9-12 wk of immunosuppression. an assessment of the severity of the induced pcp was made, based on the total number of organisms extracted from the lungs ... | 1991 | 1818139 |
| an improved rat model of pneumocystis carinii pneumonia: induced infections in pneumocystis-free animals. | an immunosuppressed rat model of pneumocystis carinii pneumonia (pcp) is described that results in a predictable course of disease development which includes moderate p. carinii (pc) infections in 2 to 3 weeks, heavy infections in 4 to 5 wk, and a high percentage of mortality due to pcp in 6 wk. the model also provides uninfected, immunosuppressed contemporary controls, an experimental compartment that is needed to correctly interpret results obtained from many different studies. non-invasive in ... | 1991 | 1818140 |
| the piglet as a potential model of pneumocystis carinii pneumonia. | spontaneous pneumocystis carinii infections occur in piglets. in this report we describe the symptoms, pathology and predisposing conditions of p. carinii pneumonia in the pig. we also discuss the advantages and disadvantages of the pig as an experimental system to study p. carinii pneumonia. | 1991 | 1818142 |
| 566c80, an antimalarial hydroxynaphthoquinone with broad spectrum: experimental activity against opportunistic parasitic infections of aids patients. | hydroxynaphthoquinone 566c80 was synthesised and initially developed as an antimalarial with potent activity against drug-resistant strains of the human malaria parasite, plasmodium falciparum. subsequent studies have revealed that in addition, this compound has experimental activity, both in vitro and in vivo, against pneumocystis carinii and toxoplasma gondii; the data obtained thus far for cryptosporidium parvum are equivocal. currently 566c80 is being assessed clinically not only against mal ... | 1991 | 1818143 |
| a radiometric method for objectively screening large numbers of compounds against pneumocystis carinii in vitro. | a relatively simple method is reported for accurately quantitating the incorporation of [3h]para aminobenzoic acid (paba) into the folates of pneumocystis carinii cultured in vitro, and the subsequent development of a highly sensitive and reproducible 96-well microtitre plate drug screening system. incorporation of [3h]paba under optimized conditions has been utilized as a selective indicator of the in vitro viability of p. carinii against which the inhibitory effects of potential drugs were qua ... | 1991 | 1818144 |
| treatment of experimental pneumocystis carinii pneumonia with 1,3-di(4-imidazolino-2-methoxyphenoxy)propane lactate. | an analogue of pentamidine, 1,3-di(4-imidazolino-2-methoxyphenoxy)propane (dmp) lactate, was tested against rat pneumocystis carinii pneumonia (pcp). the drug was found to be highly active in the treatment of rat pcp at a dose of 1.75 mg/kg (parent molecule) when administered by intravenous (i.v.) injection (daily for 2 wk). the compound was also active against pcp when given orally, however, significantly higher doses of dmp were necessary when compared to the i.v. dosing regimen. prophylactic ... | 1991 | 1818146 |
| treatment and prevention of pneumocystis carinii pneumonia and further elucidation of the p. carinii life cycle with 1,3-beta-glucan synthesis inhibitor l-671,329. | two different classes of 1,3-beta-glucan synthesis inhibitors, the echinocandins and papulacandins, have anti-pneumocystis activity in an immunosuppressed rat model for acute p. carinii pneumonia (pcp). this activity combined with potent anti-candida activity makes the echinocandins attractive agents for treating both pneumocystis and candidiasis in the immunocompromised patient. natural product echinocandin l-671,329 rapidly eliminates greater than 99% of the p. carinii cysts after 4 days of tr ... | 1991 | 1818147 |
| macrolide-antifol synergism in anti-pneumocystis carinii therapeutics. | the synergistic activities of anti-pneumocystis drugs were investigated. macrolide antibiotics alone and in combination with sulfonamides were tested for their effects on p. carinii pneumonia in rats. | 1991 | 1818149 |
| the effect of primaquine on the ultrastructural morphology of pneumocystis carinii. | ultrastructural examination of pneumocystis grown on wi-38 human embryonic lung fibroblasts and treated with primaquine indicated progressive deterioration of cellular morphology. thus, primaquine had a cidal effect on the organisms. | 1991 | 1818151 |
| immunologic comparisons of pneumocystis carinii strains obtained from rats, ferrets, and mice using convalescent sera from the same sources. | pneumocystis carinii (pc) infections were developed in animals immunosuppressed by dexamethasone treatment either from activation of latent infection (ferret) or trans-tracheal inoculation of pc obtained from infected lungs of the homologous species (rat, mouse). convalescent antisera were obtained by stopping dexamethasone treatment after 2-4 wk and allowing 5-8 wk for recovery. parasites from infected lungs were purified by differential filtration, solubilized in loading buffer, subjected to s ... | 1991 | 1818152 |
| new rapid method for the study of pneumocystis carinii interaction with alveolar macrophages. | understanding the pathophysiology of pneumocystis carinii infection has been limited by the availability of methods for precisely measuring the interaction of p. carinii with host cells. here we describe a new method which allows for the rapid assessment of p. carinii binding to, and internalization by, adherent alveolar macrophages. the method is based on the detection of fluorescein-labelled p. carinii by an automated fluorescence measurement system. | 1991 | 1818154 |
| host-parasite relationship in pneumocystis carinii infection: activation of the plasmalemmal vesicular system in type i alveolar epithelial cells. | ultrastructural studies of the attachment zone between pneumocystis carinii (pc) and type i alveolar epithelial cells showed a new aspect of the host-parasite relationship, i.e. an activation of the plasmalemmal vesicular system in the alveolar cells associated with pc trophozoites in close apposition. this phenomenon may be involved in the nutrition of the trophozoite. | 1991 | 1818155 |
| identification and purification of a soluble species of gp120 released by zymolyase treatment of pneumocystis carinii. | purified zymolyase containing beta-glucanase activity releases a soluble species of the gp120 component of the high molecular weight surface antigen complex of rat- and human-derived pneumocystis carinii. we have purified the soluble gp120 from rat-derived p. carinii by concanavalin a-affinity- and hydrophobic-interaction liquid chromatography. a single band was detected in this fraction by silver staining and immunoblotting. we have also partially purified a soluble form of the corresponding hi ... | 1991 | 1818156 |