Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| thyroid hormone-induced oxidative damage on lipids, glutathione and dna in the mouse heart. | oxygen radicals of mitochondrial origin are involved in oxidative damage. in order to analyze the possible relationship between metabolic rate, oxidative stress and oxidative damage, of1 female mice were rendered hyper- and hypothyroid by chronic administration of 0.0012% l-thyroxine (t4) and 0.05% 6-n-propyl-2-thiouracil (ptu), respectively, in their drinking water for 5 weeks. hyperthyroidism significantly increased the sensitivity to lipid peroxidation in the heart, although the endogenous le ... | 2001 | 11697138 |
| thyroid function tests, serum lipids and gender interrelations in a middle-aged population. | to study the value of screening for thyroid function in a screening program for hyperlipidaemia. | 2001 | 11697562 |
| the role of the left temporal region under the cognitive motor demands of shooting in skilled marksmen. | a number of investigators have reported elevated left temporal alpha power in marksmen during response preparation. this finding has been interpreted to indicate the suppression of irrelevant cognitive processes. however, lower-order motor processes have not been excluded as a possible explanation. event-related alpha power (11-13 hz) was examined at sites t3, t4, c3, and c4 in eight skilled marksmen during shooting and two control tasks varying in perceptual-motor complexity. over an 8-s period ... | 2001 | 11698117 |
| percutaneous ethanol injection of autonomous thyroid nodules with a volume larger than 40 ml: three years of follow-up. | autonomous thyroid nodules are conventionally treated by surgery or radioiodine. percutaneous ethanol injection is a recognized alternative approach. an assessment of the long-term success and safety was conducted. | 2001 | 11603892 |
| predictive value of altered p27kip1 and p21waf/cip1 protein expression for the clinical prognosis of patients with localized prostate cancer. | the p21waf/cip and the p27kip1 genes have been identified as inductors of cell cycle arrest at the g1-checkpoint. alterations of both genes have been suggested to be involved in the development of a variety of human malignancies due to a loss of critical antiproliferative mechanisms. to evaluate the prognostic importance of these alterations for patients with clinically localized prostate cancer, in 86 specimens (t1-t4) from 86 patients undergoing radical prostatectomy at the department of urolo ... | 2001 | 11605074 |
| the ul6 gene product forms the portal for entry of dna into the herpes simplex virus capsid. | during replication of herpes simplex virus type 1 (hsv-1), viral dna is synthesized in the infected cell nucleus, where dna-free capsids are also assembled. genome-length dna molecules are then cut out of a larger, multigenome concatemer and packaged into capsids. here we report the results of experiments carried out to test the idea that the hsv-1 ul6 gene product (pul6) forms the portal through which viral dna passes as it enters the capsid. since dna must enter at a unique site, immunoelectro ... | 2001 | 11602732 |
| the minimum effective dose of 0.5% hyperbaric spinal bupivacaine for cesarean section. | the aim of this prospective, blind study was to determine the minimum effective dose of hyperbaric bupivacaine required for cesarean section. | 2001 | 11602876 |
| a tale of two hsv-1 helicases: roles of phage and animal virus helicases in dna replication and recombination. | helicases play essential roles in many important biological processes such as dna replication, repair, recombination, transcription, splicing, and translation. many bacteriophages and plant and animal viruses encode one or more helicases, and these enzymes have been shown to play many roles in their respective viral life cycles. in this review we concentrate primarily on the roles of helicases in dna replication and recombination with special emphasis on the bacteriophages t4, t7, and a as model ... | 2001 | 11642367 |
| involvement of level i neck lymph nodes in advanced squamous carcinoma of the larynx. | this study was performed to evaluate the incidence of metastasis at level i in patients with squamous laryngeal cancer. one hundred consecutive patients with squamous carcinoma of the larynx were submitted to surgical treatment including radical neck dissection. the tumor stage was t3 or t4, and the neck stage was n1-n2c. lymph node metastases were pathologically confirmed in 80 patients. metastases were concentrated within level ii in 59% of cases, level iii in 17% of cases, level iv in 11% of ... | 2001 | 11642434 |
| [screening for thyroid disease. occurrence of hypothyroidism and hyperthyroidism in patients admitted to a geriatric department]. | the aim of this study was to evaluate whether screening of all geriatric patients for thyroid disorders should be recommended and to assess the prevalence of thyroid dysfunction in a geriatric population. | 2001 | 11665469 |
| intrathecal baclofen for generalized dystonia. | the aim of this study was to evaluate the effects of intrathecal bacolfen (itb) on patients with severe generalized dystonia. eighty-six participants ranging in age from 3 to 42 years (median age 13 years) with generalized dystonia refractory to oral medications were offered treatment with itb. dystonia was associated with cerebral palsy in 71% of participants. response to itb was tested by continuous infusions in 72%, and by bolus injections in 17% of participants who had both dystonia and spas ... | 2001 | 11665821 |
| identification of a novel truncated isoform of trkb in the kitten primary visual cortex. | neurotrophins have been shown to play important roles in development and plasticity of the visual cortex (vc). since signal transduction of neurotrophins is mediated through neurotrophin receptors, we attempted to analyze neurotrophin receptors in the vc. in this study, we isolated cdnas encoding the intracellular regions of truncated isoforms of the trkb receptor from 30-d-old kitten primary vc. two distinct truncated isoforms of trkb were isolated and characterized by sequence analyses. one of ... | 2001 | 11665865 |
| endoscopic thoracic sympathetic block by clipping for palmar and axillary hyperhidrosis in children and adolescents. | endoscopic thoracic sympathectomy or sympathicotomy is a safe and effective method of treating primary hyperhidrosis (ph), but postoperative compensatory sweating may be a problem. there are few reports of sympathetic blockade by clipping for ph. we present our experience of endoscopic thoracic sympathetic block (etsb) by clipping in treating palmar (pah) and axillary hyperhidrosis (ah) in children and adolescents. between may 1997 and june 1998, a total of 78 patients with pah or ah underwent e ... | 2001 | 11666053 |
| the effect of low temperature and fasting during the winter on metabolic stores and endocrine physiology (insulin, insulin-like growth factor-i, and thyroxine) of coho salmon, oncorhynchus kisutch. | the objective of this study was to examine the effect of winter feeding and fasting at both high (10 degrees ) and low (2.5 degrees ) temperatures on growth, metabolic stores, and endocrinology of coho salmon. treatments were as follows: warm-fed, warm-not fed, cold-fed, and cold-not fed during the winter (january-february). the following parameters were measured: length, weight, whole body lipid, liver glycogen, hepatosomatic index, and plasma levels of insulin, insulin-like growth factor-i (ig ... | 2001 | 11589631 |
| tsh-receptor antibody measurement for differentiation of hyperthyroidism into graves' disease and multinodular toxic goitre: a comparison of two competitive binding assays. | graves' disease is characterized by stimulating autoantibodies to the tsh-receptor (trab). the aim of this study was to compare the performance of a new trab assay based on competitive binding to recombinant human tsh-receptors (h-trab) with an assay employing purified porcine tsh-receptors (p-trab). furthermore, to evaluate the applicability of the h-trab assay to discriminate between patients with hyperthyroidism due to graves' disease (gd) and multinodular toxic goitre (mntg). | 2001 | 11589682 |
| prevalence of gestational thyrotoxicosis in asian women evaluated in the 8th to 14th weeks of pregnancy: correlations with total and free beta human chorionic gonadotrophin. | the prevalence of gestational transient thyrotoxicosis (gtt) in europeans evaluated during the 8th to 14th weeks of pregnancy is 2-3%. however, there is evidence that gtt may be more common in some asian populations. the aims of this study were to evaluate the prevalence of thyroid hormone abnormalities in asian women in their 8th to 14th weeks of pregnancy using highly sensitive free t4 and tsh assays and to correlate these with total and free beta-hcg levels. | 2001 | 11589683 |
| comparison of immune parameters of sheep with naturally high or low plasma concentrations of melatonin. | studies in rodents and humans have suggested that the pineal gland and its secretory product melatonin play an important role in the modulation of the immune system. in this study, we tested the hypothesis of a difference in immune parameters between ewes with naturally high vs. low circulating melatonin. thus, two comparable groups of 10 ile-de-france sheep were selected from a large flock, for their naturally high and low plasma concentrations of melatonin. the mean plasma melatonin concentrat ... | 2001 | 11589760 |
| alterations in an ire1-rna complex in the mammalian unfolded protein response. | ire1 proteins mediate cellular responses to accumulation of malfolded proteins in the endoplasmic reticulum in the yeast and mammalian unfolded protein responses. a sensitive in vivo u.v. crosslinking assay showed that ire1 proteins are intimately associated with rna in mammalian cells. the ire1-associated rna fragments recovered by this assay were different in stressed and unstressed cells. the amount of rna associated with ire1 that could be revealed by end-labeling with t4 kinase was greater ... | 2001 | 11590247 |
| neonatal goiter caused by expectorant usage. | a female newborn was admitted with the symptoms of mild respiratory distress, protruding tongue, hypotonicity, cutis marmorata, sclerema, myxedema, abdominal distension, and feeding problems on the first day of life. she had a huge neck mass, a large anterior and posterior fontanel, and hoarse cry. she had no umbilical hernia or jaundice. a history of maternal potassium iodine (expectorant) usage without doctor's advice was obtained; the mother had not attended a clinic throughout the pregnancy. ... | 2001 | 11592576 |
| p300 asymmetry in schizophrenia: a meta-analysis. | p300 event-related brain potential (erp) amplitude is smaller in patients with schizophrenia compared to unaffected controls, but whether left temporal component amplitude is also smaller is debated. the present study employed meta-analytical methods to quantitatively assess previous p300 schizophrenia asymmetry findings. all p300 articles on schizophrenia using an auditory oddball paradigm published before january 2000 were obtained by comprehensive literature searches and cross-referencing for ... | 2001 | 11600190 |
| analysis of intracellular didanosine triphosphate at sub-ppb level using lc-ms/ms. | an analytical procedure has been developed for the analysis of intracellular didanosine triphosphate (ddatp). an electrospray ionization tandem mass spectrometer (esi-ms) was interfaced to liquid chromatography (lc) using a mobile phase ch3oh/h2o (25/75) containing 1% formic acid for the analysis of the 5'-triphosphate metabolite of the antiviral didanosine. in this procedure, ddatp was extracted from cem-t4 cells, isolated using an exchange anion solid phase extraction procedure, enzymatically ... | 2001 | 11600293 |
| what is your neurologic diagnosis? osteochondroma of the dorsal process of t4. | 2001 | 11601785 | |
| stepwise deletion of the hiv type 1 glycoprotein 41 n terminus leads to an increasing export of microvesicles containing uncleaved env glycoprotein. | deletion of two or more amino acid residues from the n terminus of hiv-1 gp41 leads to an increasing loss of cleavability of the envelope (env) precursor on introduction of an env-expressing vector into hela-t4+ cells. in protein analysis, this is paralleled by the appearance of a second form of uncleaved env precursor that is terminally sialylated. cell-derived microvesicles that preferentially incorporate this form of env precursor were found in the culture medium. the same applies to a mutant ... | 2001 | 11602045 |
| cloning, sequence and structure of a gene encoding an antifungal glucan 1,3-beta-glucosidase from trichoderma atroviride (t. harzianum). | a gene (gluc78) encoding an antifungal glucan 1,3-beta-glucosidase was cloned from strain p1 of the biocontrol fungus trichoderma atroviride (formerly t. harzianum). a putative regulatory sequence upstream from the coding region was cloned using single-strand extension from a primer in the known portion of the gene, circularized with t4 ligase, and then reamplified with pcr to generate double-stranded dna. the entire genomic dna sequence consisted of 3440 bp, with 559 and 579 bp, respectively, i ... | 2001 | 11602357 |
| postmastectomy radiotherapy in women with breast cancer metastatic to one to three axillary lymph nodes. | the influence of postmastectomy radiotherapy on survival has long been debated. early randomized trials established a clear role for adjuvant postmastectomy chest wall radiotherapy (pmcwrt) in reducing locoregional recurrence (lrr), and pmcwrt became standard therapy for patients at high risk of lrr: those with t3 or t4 tumors and four or more involved lymph nodes. however, without effective systemic therapy, distant metastases limited any effect of improved local control on overall outcome, and ... | 2001 | 11595118 |
| off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. | oxidative stress and renal dysfunction occur in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (on-pump cabg). whether the same adverse effects also occur during off-pump cabg is the question in this study. | 2001 | 11675176 |
| [brain metastases from esophageal cancers: clinical features and treatment results]. | metastatic brain tumors from esophageal cancer are relatively rare. we analyzed the clinical features and results of treatment in 14 cases of brain metastases from esophageal carcinoma. the average time to diagnosis of brain metastases in the 11 patients with metachronous lesions was 13 months. the average age of patients at the diagnosis of brain metastasis was 65 years. most patients had t4 or n1 disease at the time of diagnosis of esophageal cancer. performance status of grade 3 was most freq ... | 2001 | 11676170 |
| characterization and mapping of dna damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) at nucleotide resolution in human genomic dna. | the nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) is an important tobacco-specific carcinogen associated with lung cancer. its complex enzymatic activation, leading to methyl and pyridyloxobutyl (pob)-modified dna, makes dna damage difficult to characterize and quantify. therefore, we use the nnk analogue 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (nnkoac) to induce damage in genomic dna, and to map the sites and frequency of adducts at nucleotide resolution using ... | 2001 | 11676538 |
| oxygen free radical damage to dna. translesion synthesis by human dna polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. | cyclopurine deoxynucleosides are common dna lesions generated by exposure to reactive oxygen species under hypoxic conditions. the s and r diastereoisomers of cyclodeoxyadenosine on dna were investigated separately for their ability to block 3' to 5' exonucleases. the mammalian dna-editing enzyme dnase iii (trex1) was blocked by both diastereoisomers, whereas only the s diastereoisomer was highly efficient in preventing digestion by the exonuclease function of t4 dna polymerase. digestion in bot ... | 2001 | 11677235 |
| the effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. | many hyperthyroid cats referred for thyroid imaging and 131i therapy are concurrently or recently receiving antithyroid medications. the effect of the antithyroid drug, methimazole, on thyroid uptake of 99mtco4 and 123i was evaluated in 8 normal cats. quantitative analysis was used to determine the normal percent dose uptake of 99mtco4 and 123i, the change in thyroid:salivary ratios (t:s) of 99-tco4 over time, and the duration of the methimazole effect on thyroid uptake of 123i. methimazole was ... | 2001 | 11678569 |
| thyroid function in the newborn in relation to maternal thyroid status during labour in a mild iodine deficiency endemic area in sudan. | data on neonatal and maternal thyroid function during labour in a mild iodine deficiency endemic area are lacking. the current study focuses on elucidating the thyroid function during labour, in a group of pregnant women who live in an area of mild iodine deficiency in sudan compared to that observed in their corresponding newborns. | 2001 | 11678831 |
| long-term follow-up of contralateral lobe in patients hemithyroidectomized for solitary follicular adenoma. | since there are no available conclusive studies on the long-term evolution of remnant thyroid tissue after hemithyroidectomy in patients who undergo surgery for solitary follicular adenomas, we searched for such cases in our records to elucidate this issue. | 2001 | 11678834 |
| practical approach to patients presenting with multiple synchronous suspect lung lesions: a reflection on the current tnm classification based on 54 cases with complete follow-up. | to examine the survival after surgical treatment of patients presenting with two synchronous suspect lung lesions, and to reflect on the recent tnm classification, which has upgraded patients with two malignant lung lesions of the same histology into the t4 (both lesions in the same ipsilateral lobe) or m1 (different lobes or lungs) category. | 2001 | 11679175 |
| comparison of hydro-us and spiral ct in the staging of gastric cancer. | the purpose of this study was to compare the diagnostic accuracy of hydro-ultrasonography (us) and spiral computed tomography (ct) in the staging of gastric cancer. forty-three patients with gastric cancers confirmed at surgery underwent hydro-us and spiral ct on the same day prospectively. hydro-us and spiral ct were done after ingestion of water. us and ct images were independently analyzed. after surgery, pathological findings according to tnm classification were compared with us and ct findi ... | 2001 | 11679225 |
| in vivo accuracy of thoracic pedicle screws. | a retrospective observational study of 279 transpedicular thoracic screws using postoperative computed tomography (ct). | 2001 | 11679819 |
| [surgical strategy in rectosigmoidal cancer]. | colorectal cancer is frequent and diagnosed earlier thanks to the screening and to the progresses in the preoperative assessment. the precocity of the surgical resection takes advantage from the complete resection of vascular and nodes involvement. the rectal localisation of the cancer requires to take the reconstruction into account. if preoperative radiotherapy is helpful in t4 and t3 n2 and locally advanced tumour, the surgeon should consider the four approaches of rectal cancer: the anterior ... | 2001 | 11680177 |
| children with non-verbal learning disabilities (nld): coherence values in the resting state may reflect hypofunctional long distance connections in the right hemisphere. | eeg intrahemispheric coherences (hcohs) in the resting state in twenty-four 4 hz frequency windows between 1 and 51 hz were studied in 18 children with "non-verbal learning disorder" (nld) and compared to a group of 18 children with "verbal learning disorder" (vld). new facts were found in the nld group. these concern hemispheric balance, expressed as left minus right (l-r) homologous hcohs: 1a). in the high frequencies (25-51 hz) the number of long-distance hcohs, higher in the right hemisphere ... | 2001 | 11680298 |
| [survival benefits of and indications for extended surgery for advanced gastric cancer]. | the surgical management of locally advanced gastric cancer remains controversial. it is also unclear whether the postoperative survival rate could be improved by extended lymph node dissection. the aim of this paper is to determine the survival benefit of and the indications for extended surgery. lymph node metastasis in the paraaortic area frequently occurs in locally advanced cardiac cancer. in our previous studies, the paraaortic lymph nodes above and below the left renal vein were confirmed ... | 2001 | 11681003 |
| differential expression of na:k:2cl cotransporter, glucose transporter 1, and aquaporin 1 in freshly isolated and cultured bovine corneal tissues. | little is known about whether culturing corneal limiting layers causes changes in the expression of their membrane transporter proteins from those present in fresh tissues. accordingly, we compared mrna abundance of three well-described types of transporters: water channel aquaporin 1 (aqp1), glucose transporter (glut1), and na:k:2cl cotransporter (nkcc), as well as nkcc protein levels in fresh bovine corneal epithelium and endothelium with those in their cultured counterparts. abundance of mrna ... | 2001 | 11682698 |
| bone mineral density in male patients with l-thyroxine suppressive therapy and graves disease. | little is known about the effects of thyroid hormone excess in male patients. our aim was to evaluate bone mineral density (bmd), bone turnover markers, and thyroid function in male patients with treated thyroid cancer on long-term suppressive l-t4 therapy (tc) and in male patients with graves' disease (gd). we studied 49 male patients (aged 45+/-12 years), 17 with tc (29-288 months on l-t4 suppressive therapy; free t4: 1.9+/-0.6 ng/dl [normal< or =2.0]; tsh: 0.2+/-0.3 microu/ml [normal 0.5-5.0] ... | 2001 | 11683428 |
| selenium, selenoproteins and human health: a review. | selenium is of fundamental importance to human health. it is an essential component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defence systems, and immune function. the decline in blood selenium concentration in the uk and other european union countries has therefore several potential public health implications, particularly in relation to the chronic disease prevalence of the western world such as cancer and cardiovascular disease. ten years have elap ... | 2001 | 11683552 |
| intraoperative epidural blockade prevents the increase in protein breakdown after abdominal surgery. | the aim of this study was to investigate the effect of epidural blockade with bupivacaine, restricted to the intraoperative period, on protein catabolism after major abdominal surgery. | 2001 | 11683666 |
| upper tract transitional cell carcinoma following cystectomy for bladder cancer. | we assessed the incidence of upper urinary tract tumors (uutts) after cystectomy for invasive or superficial transitional cell carcinoma (tcc) of the bladder. the risk factors, patients' characteristics and evolution of those who developed uutts are analyzed. | 2001 | 11684849 |
| preoperative radiochemotherapy and sphincter-saving resection for t3 carcinomas of the lower third of the rectum. | to evaluate the complications and oncologic and functional results of preoperative radiochemotherapy and sphincter-saving resection for t3 cancers of the lower third of the rectum. | 2001 | 11685026 |
| studying excited states of proteins by nmr spectroscopy. | protein structure is inherently dynamic, with function often predicated on excursions from low to higher energy conformations. for example, x-ray studies of a cavity mutant of t4 lysozyme, l99a, show that the cavity is sterically inaccessible to ligand, yet the protein is able to bind substituted benzenes rapidly. we have used novel relaxation dispersion nmr techniques to kinetically and thermodynamically characterize a transition between a highly populated (97%, 25 degrees c) ground state confo ... | 2001 | 11685237 |
| autonomic dysreflexia and primary afferent sprouting after clip-compression injury of the rat spinal cord. | spinal cord injury leads to many forms of autonomic dysfunction including autonomic dysreflexia, a condition involving recurrent episodes of paroxysmal hypertension and associated bradycardia. this hypertension may reach intensities that are life-threatening. we investigated autonomic dysreflexia and the sprouting of central processes of primary afferent neurons (a potential mechanism for autonomic dysreflexia) in a clinically-relevant calibrated clip-compression model of spinal cord injury in t ... | 2001 | 11686496 |
| [involvement of thyroid hormones in mental recovery following severe craniocerebral trauma]. | to study a role of thyroid hormones in the recovery of mental performance, 71 patients (60 males, 11 females) aged 7 to 66 years (mean age 32.7 +/- 3.5) with severe brain injury (tbi). according to the stage of mental recovery (1--none; 2--elementary acts; 3--verbal contact; 4--spatial orientation; 5--intellectual and mnestic processes and emotional and personality traits), the study was divided into 5 series. immunoradiometric assay of thyroid hormones (t3 and t4) and their free fractions (ft3 ... | 2001 | 11544736 |
| non-painful and painful surface and intramuscular electrical stimulation at the thenar and hypothenar sites: differential cerebral dynamics of early to late latency seps. | little is known about somatosensory evoked potentials (seps) from muscle stimulation compared to that from skin stimulation. the current study examined this issue in the full sep spectrum (0-440 ms). the aims of the study were to (1) establish the dynamics of early to late latency seps from intramuscular stimulation in contrast to surface stimulation, (2) compare the effect of non-painful and painful stimuli on sep latencies and amplitudes of the two methods, and (3) investigate to which extent ... | 2001 | 11545157 |
| influence of root temperature on phytoaccumulation of as, ag, cr, and sb in potato plants (solanum tuberosum l. var. spunta). | three consecutive years of field experiments were carried out to investigate the effect of root temperatures induced by the application of mulches for phytoextraction of as, ag, cr and sb using potato plants (roots, tubers, stems and leaflets). four different plastic covers were used (t1: transparent polyethylene; t2: white polyethylene; t3: white and black coextruded polyethylene; and t4: black polyethylene), taking uncovered plants as control (t0). the different treatments had a significant ef ... | 2001 | 11545361 |
| the addition of fentanyl does not alter the extent of spread of intrathecal isobaric bupivacaine in clinical practice. | fentanyl is commonly added to intrathecal local anesthetic solutions. in vitro data has shown fentanyl to render isobaric local anesthetics hypobaric, and alter the spread in artificial cerebrospinal fluid. this study examined whether the addition of fentanyl to isobaric bupivacaine with morphine leads to a clinically important alteration in the extent of spread of anesthesia. | 2001 | 11546717 |
| analysis of the postprandial lipid metabolism: use of a 3-point test. | the oral fat load tests used to study postprandial lipemia are complex and costly and time consuming. a simplified fat load test could be more convenient and more appropriate in routine clinical practice because of the number of lipid determinations required. | 2001 | 11547218 |
| [dyshormonal strain bone disease in young people]. | there were studied 453 young servicemen with dyshormonal strain bone disease in whom the hormonal status, state of carbohydrate and protein metabolism were investigated. it was established that in 92.9% of patients the growth hormone--somatotropic hormone (sth) was significantly decreased, production of thyroid hormones necessary for physiologic osteogenesis (t3 and t4) was impaired and albuminous fraction dissociation was revealed. the authors consider that in dyshormonal strain bone disease in ... | 2001 | 11547661 |
| bacteriophage t4 multiplication in a glucose-limited escherichia coli biofilm. | an escherichia coli k-12 biofilm was grown at a dilution rate of 0.028 h(-1) for 48 h in a glucose-limited chemostat coupled to a modified robbins' device to determine its susceptibility to infection by bacteriophage t4. bacteriophage t4 at a multiplicity of infection (moi) of 10 caused a log reduction in biofilm density (expressed as colony forming units (cfu) per cm2) at 90 min postinfection. after 6 h, a net decrease and equilibrium in viral titer was seen. when biofilms were exposed to t4 ph ... | 2001 | 11547890 |
| subtotal laryngectomy with cricohyoidopexy as first treatment procedure for supraglottic carcinoma: institut gustave-roussy experience (146 cases, 1974-1997). | between 1974 and 1997, 297 patients underwent a subtotal laryngectomy at the institut gustave-roussy; 146 of these patients underwent cricohyoidopexy (chp) for a supraglottic primary as their first treatment. the majority of patients were men (137) aged from 33 to 78 years (median 54 years). the tumour stage at presentation was t1 in 2, t2 in 87, t3 in 53 (preepiglottic space involvement), and t4 (minimal thyroid cartilage invasion) in 4 patients. one hundred and twenty-five patients were n0 (86 ... | 2001 | 11548904 |
| thyroid status and leptin in basedow-graves and multinodular goiter patients. | in this study it was of interest to investigate the relationship between plasma leptin levels and thyroid function in recently diagnosed 27 basedow-graves patients and 22 multinodular goiter patients brought to euthyroid state with 1 mo of propylthiouracil (ptu) treatment. a group of 15 control subjects matched for age, gender, and body mass index were also studied. in basedow-graves patients there were significantly higher t4 and t3 levels accompanied by a marked fall in plasma thyroid-stimulat ... | 2001 | 11549117 |
| distinct orders of galnac incorporation into a peptide with consecutive threonines. | mucin o-glycosylation is initiated by a transfer of n-acetyl-d-galactosamine (galnac) to ser and thr residues in polypeptides with a family of udp-galnac:polypeptide n-acetylgalactosaminyltransferases (pp-galnac-ts). in this paper, four human pp-galnac-ts (pp-galnac-t1, t2, t3, and t4) were tested for their preferential orders of galnac incorporation into fitc-ptttpittttk, a portion of the tandem repeat of human muc2. the products were separated by reverse-phase hplc and characterized by maldi-t ... | 2001 | 11549261 |
| altered expression of receptors for thyroid hormone and insulin-like growth factor-i during reconstitution after allogeneic hematopoietic stem cell transplantation. | treatment with neuroendocrine hormones has been suggested to promote reconstitution of the immune system after hematopoietic stem cell transplantation (hsct). we investigated the expression of genes encoding receptors for growth hormone (gh), insulin-like growth factor-i (igf-i) and triiodothyronine (t3), at various time points after hsct in 16 patients and 15 healthy controls. peripheral blood mononuclear cells were isolated and rna for gh receptor (ghr), igf-i receptor (igf-ir) and thyroid hor ... | 2001 | 11551027 |
| characterization of a sea bream (sparus aurata) thyroid hormone receptor-beta clone expressed during embryonic and larval development. | a clone encoding thyroid hormone receptor-beta (tr-beta) was isolated from a sea bream (sparus aurata) ovary cdna library. sea bream (sb)tr-beta is closely related to its counterparts from other vertebrates and, like them, preferentially binds t3 rather than t4. however, the putative sbtr-beta protein contains a nine-amino-acid insert that is also present in the corresponding proteins from flounder and salmon but absent in tr-betas from zebrafish and terrestrial vertebrates. semiquantitative rt- ... | 2001 | 11551120 |
| dynamic protein interactions in the bacteriophage t4 replisome. | the bacteriophage t4 dna replisome is a complex dynamic system employing a variety of proteins to orchestrate the synthesis of dna on both the leading and lagging strands. assembly of the protein complexes responsible for dna synthesis and priming requires the coordination of transient biomolecular interactions. this interplay of proteins has been dissected through the use of small molecules including fluorescent probes and crosslinkers, enabling the development of a complex dynamic structural a ... | 2001 | 11551794 |
| molecular cloning and sequence of sparus aurata skeletal myosin light chains expressed in white muscle: developmental expression and thyroid regulation. | two full-length cdna clones encoding the skeletal myosin light chain 2 (mlc2; 1452bp) and myosin light chain 3 (mlc3; 972bp) were isolated from a cdna library prepared from gilthead sea bream sparus aurata larvae. the mlc2 cdna encoded a predicted protein of 170 residues that was 79% identical to rabbit mlc2 over the entire length and 87% identical within the ca(2+)-binding region. the deduced amino acid sequence of mlc3 was 153 residues in length and was 91% and 69% identical to the zebrafish a ... | 2001 | 11551989 |
| immunohistochemical and clinicopathologic analysis of response to neoadjuvant therapy for esophageal squamous cell carcinoma. | recently, neoadjuvant chemotherapy combined with radiation (nat) has been used in the active treatment of progressive esophageal cancer (t4). however, many patients are resistant to supplemental therapy, and it is necessary to to be aware that side-effects may occur. accordingly, to minimize adverse reactions and cost, it is important to determine the indications for nat. we investigated 34 patients with t4 esophageal squamous cell carcinoma and examined the relation between the effects of nat a ... | 2001 | 11553227 |
| members of the cytophaga-flavobacterium-bacteroides phylum as intracellular bacteria of acanthamoebae: proposal of 'candidatus amoebophilus asiaticus'. | three gram-negative, rod-shaped bacteria that were found intracellularly in two environmental and one clinical acanthamoeba sp. isolates were analysed. two endocytobionts showing a parasitic behaviour were propagated successfully outside their amoebal host cells and were identified subsequently by comparative 16s rrna sequence analysis as being most closely affiliated with flavobacterium succinicans (99% 16s rrna sequence similarity) or flavobacterium johnsoniae (98% 16s rrna sequence similarity ... | 2001 | 11553234 |
| a conserved genetic module that encodes the major virion components in both the coliphage t4 and the marine cyanophage s-pm2. | sequence analysis of a 10-kb region of the genome of the marine cyanomyovirus s-pm2 reveals a homology to coliphage t4 that extends as a contiguous block from gene (g)18 to g23. the order of the s-pm2 genes in this region is similar to that of t4, but there are insertions and deletions of small orfs of unknown function. in t4, g18 codes for the tail sheath, g19, the tail tube, g20, the head portal protein, g21, the prohead core protein, g22, a scaffolding protein, and g23, the major capsid prote ... | 2001 | 11553768 |
| screening for thyroid disease of 15-17-year-old schoolchildren in an area with normal iodine intake. | the prevalence of thyroid disease in swedish schoolchildren is today insufficiently known. the aim of the study was therefore to determine the prevalence of abnormal thyroid function and thyroid autoimmunity in teen-age schoolchildren and to compare the findings with a healthy control group of 60-65-year-old inhabitants from the same community. | 2001 | 11555124 |
| evidence for glycosylation-dependent activities of polypeptide n-acetylgalactosaminyltransferases rgalnac-t2 and -t4 on mucin glycopeptides. | we present evidence that site-specific o-glycosylation by recombinant polypeptide n-acetylgalactosaminyltransferases rgalnac-t2 and -t4 is controlled by the primary sequence context, as well as by the position and structure of previously introduced o-glycans. synthetic mucin-type (glyco)peptides corresponding to sections of the tandem repeat regions of muc1, muc2, and muc4 were used as substrates for recombinant polypeptide n-acetylgalactosaminyltransferases, rgalnac-t2 and -t4. by concerted and ... | 2001 | 11555617 |
| risk factors of urethral involvement of bladder cancer after radical cystectomy with orthotopic neobladder in females. | the cystectomy and urethrectomy specimens of 20 females with invasive bladder cancer were studied for evidence of urethral involvement. the bladder showed transitional cell carcinoma in 18 cases (90%) and squamous cell carcinoma in 2 cases (10%). urethral involvement was found in 5 cases (25%). the trigone was the most common site of tumor (50%) which had 33 per cent chance of urethral involvement. bladder neck was the next common site of tumor (15%) and had 66 per cent chance of urethral involv ... | 2001 | 11556471 |
| [sagittal cobb-angle measurements in scoliosis with mri whole spine imaging]. | a newly developed mr procedure allows imaging of the whole spine in coronal and sagittal planes. we studied the use of total spine mr imaging in measuring sagittal cobb angles in scoliosis. | 2001 | 11558047 |
| interpretation of thyroid function tests. | the introduction of sensitive thyrotropin assays and free thyroid hormone measurements has simplified the interpretation of thyroid function tests. however, important pitfalls and difficult cases still exist. in this review, thyroid function test results are grouped into six different patterns. we propose that if assays for thyrotropin, free t3, and free t4 are all done, knowledge of these patterns coupled with clinical details and simple additional tests allow a diagnosis to be made in almost a ... | 2001 | 11558500 |
| galactosyldiacylglycerol, a mammalian dna polymerase alpha-specific inhibitor from a sea alga, petalonia bingbamiae. | the glycolipid galactosyldiacylglycerol (gdg), containing c16:0 and c18:1 fatty acids, was isolated from the sea alga petalonia bingbamiae as a potent inhibitor of the activities of mammalian dna polymerase alpha (pol. alpha). gdg, however, had no effect on pol. alpha from a fish or a higher plant. the inhibition of pol. alpha by gdg was dose-dependent with an ic50 value of 54 microm. the compound did not influence the activities of other replicative dna polymerases such as mammalian pol. delta, ... | 2001 | 11558581 |
| maternal dietary iodide influences turkey embryonic thyroid function. | an experiment was designed to examine a mechanism to improve embryonic survival following maternal thyroid hormone manipulation. commercial turkey breeder hens were fed diets containing supplemental iodide to mimic changes in the maternal thyroid output during an egg production cycle (32 to 48 wk of age). dietary iodide treatment depressed maternal blood thyroxine (t4) concentrations in a time-dependent manner. dietary iodide depressed maternal blood 3, 5, 3'-triiodothyronine (t3) levels across ... | 2001 | 11558913 |
| specific iga antibodies to recombinant early and nuclear antigens of epstein-barr virus in nasopharyngeal carcinoma. | nasopharyngeal carcinoma is a common cancer in taiwan. the epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma. the sera of patients with nasopharyngeal carcinoma have iga antibodies to a variety of ebv latent and replicated antigens. recently, an enzyme-linked immunosorbent assay (elisa) kit, combining both the ebv early antigen (ea) and nuclear antigen (ebna-1) became commercially available. the purpose of this study was to assess its clinical application. serum iga an ... | 2001 | 11559349 |
| a systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma. | endoscopic ultrasound (eus) may be used for preoperative staging of gastro-oesophageal carcinoma but performance values given in the literature differ. | 2001 | 11559651 |
| serum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin concentrations in dogs with nonthyroidal disease. | to determine whether nonthyroidal disease of various causes and severity is associated with abnormalities in baseline serum concentrations of total thyroxine (t4), triiodothyronine (t3), free t4, or thyrotropin (thyroid-stimulating hormone [tsh]) in dogs believed to be euthyroid. | 2001 | 11561650 |
| the role of histological investigation in prognostic evaluation of advanced gastric cancer. analysis of histological structure and molecular changes compared with invasive pattern and stage. | the relative contribution of tumour histology or molecular changes, compared with invasion pattern or stage, to prognostic assessment of gastric cancer was investigated in a series of 185 advanced (t2 to t4, stage ib to iv) cancers that had undergone intentionally curative surgery at varese general hospital. survival analysis of the histological types considered in commonly used classifications, such as lauren, kubo, the world health organization (who) and related classifications, allowed separa ... | 2001 | 11561756 |
| efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. | based on in vitro and on clinical evidence of protection against acute side effects of radiation, a prospective randomized, open study was performed to determine the efficacy of an oral proteolytic enzyme preparation in patients with head and neck cancer receiving conventional fractionated radiation therapy. | 2001 | 11561868 |
| kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive rt-pcr and indirect immunofluorescence. | we have previously shown that classical brain-like kappa opioid receptors (kor) are constitutively expressed in lymphocytic cells. including human cem x174 t-b hybrid cells, jurkat -t4 cells, human peripheral blood mononuclear cells (pbmc), human cd4+ cells and monkey pbmc (biochem. biophys. res. commun. 209 (1995) 1003). the present study further demonstrates that the kor of lymphocytes are activated in the presence of extracellular morphine or u50,488h, a kor selective agonist, and the activat ... | 2001 | 11562065 |
| two-generation reproduction study of ammonium perchlorate in drinking water in rats evaluates thyroid toxicity. | perchlorate is an inorganic ion that has recently been detected in drinking water supplies throughout the country, but little is known about its effects on reproductive function. this two-generation reproductive study examines the effects of ammonium perchlorate on the male and female reproductive systems in rats, and on the growth and development of offspring. adult sprague-dawley rats (30/sex/group) were given continuous access to ammonium perchlorate in their drinking water at doses of 0, 0.3 ... | 2001 | 11563414 |
| oral (drinking water) developmental toxicity study of ammonium perchlorate in new zealand white rabbits. | this developmental toxicity study was conducted to evaluate the embryo-fetal toxicity and teratogenic potential of ammonium perchlorate in new zealand white [hra:(nzw)spf] rabbits. pregnant rabbits were given continual access to ammonium perchlorate in drinking water at target doses of 0, 0.1, 1.0, 10.0, 30.0, and 100.0 mg/kg-day on gestation days 6 through 28. the actual consumed doses in the study were 0, 0.1, 0.9, 10.4, 30.3, and 102.3 mg/kg-day. the rabbits were sacrificed on gestation day 2 ... | 2001 | 11563415 |
| allelotyping in mycosis fungoides and sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p. | allelotyping studies have been extensively used in a wide variety of malignancies to define chromosomal regions of allelic loss and sites of putative tumor suppressor genes; however, until now this technique has not been used in cutaneous lymphoma. we have analyzed 51 samples from patients with mycosis fungoides and 15 with sézary syndrome using methods to detect loss of heterozygosity. micro satellite markers were selected on 15 chromosomal arms because of their proximity to either known tumor ... | 2001 | 11564174 |
| sympathetic innervation of mammary glands mediates suckling-induced reflex inhibition of milk yield in rats. | previous work has shown that physiologic activation of the sympathetic system may inhibit milk yield (me) in rats. thus, adrenal catecholamines (cas) are released by suckling, but it is not known whether such inhibition results also from reflex activation by the same stimulus of neural sympathetics upon the mammary gland. the present experiments were designed to determine whether suckling inhibits me induced by oxytocin (ot) in the urethane-anesthetized lactating rat, and whether such inhibition ... | 2001 | 11564449 |
| elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. | hypoxia shifts the balance of cellular energy production toward glycolysis with lactate generation as a by-product. quantitative bioluminescence imaging allows for the quantitation of lactate concentrations in individual tumors. we assessed the relationship between pretreatment tumor lactate concentrations and subsequent development of metastatic disease in patients with newly diagnosed head-and-neck cancer. | 2001 | 11567808 |
| base-of-tongue cancer: survival, function, and quality of life after external-beam irradiation and brachytherapy. | base-of-tongue cancer has traditionally been treated by surgical resection followed by radiation therapy. primary radiation therapy with brachytherapy has recently been proposed as an alternative. in a prior analysis, we found that patients with advanced tongue-base cancer treated by total glossectomy and postoperative radiation therapy can be cured while potentially maintaining good quality of life. therefore, we designed the current study to assess survival, function, and quality of life in ou ... | 2001 | 11568569 |
| the role of acute decompression and restoration of spinal alignment in the prevention of post-traumatic syringomyelia: case report and review of recent literature. | case report. | 2001 | 11568717 |
| diagnosis of canine hypothyroidism. perspectives from a testing laboratory. | the most common sample received by our endocrine testing laboratory is submitted for the diagnosis of hypothyroidism in a dog. the current tests most frequently employed in our laboratory for thyroid evaluation in dogs are total t4, free t4 by dialysis, and canine tsh measurement. each test has strengths and weaknesses and suffers from the possibility of both false positive and false negative results. this article provides a working description of each test and an approach to interpretation of r ... | 2001 | 11570134 |
| feline hyperthyroidism. diagnostics and therapeutics. | today, hyperthyroid cats are less symptomatic than those 10 or 15 years ago, and early diagnosis impacts the range and severity of the routine clinicopathological abnormalities traditionally associated with this disorder. in addition, a greater range of tests may be required to confirm a diagnosis as cats may be assessed before a serum total t4 concentration exceeds the reference range. curative treatment options may be more desirable in early cases, but renal function may be adversely affected ... | 2001 | 11570135 |
| treatment of severe double spinal cord injuries. | this is a case report describing an injury--sustained by a 25-year-old man during a car accident, and characterized by fracture dislocation of the spine at the level of c7 and t4 accompanied by pulmonary contusion. he had an incomplete spinal cord lesion at the level of c7 and a complete lesion at the level of t4 (t4 asia a). imaging of the spine showed three column fractures with ventral spinal cord compression at both levels. discussants of this case comment on the concept of acute treatment o ... | 2001 | 11571662 |
| hemithyroidectomy: long-term effects on parathyroid function--preliminary report. | early hypocalcemia after thyroid surgery has frequently been reported, whereas data regarding long-term effects on calcium homeostasis are scarce. we have previously studied patients after hemithyroidectomy with an oral calcium load test and found normal parathyroid hormone (pth) suppression. however, the 1,25-dihydroxyvitamin d concentration was decreased and the phosphate concentration increased, implying parathyroid insufficiency. we therefore proceeded to investigate pth secretion and suppre ... | 2001 | 11571952 |
| preoperative chemoradiation therapy and anal sphincter preservation with locally advanced rectal adenocarcinoma. | preoperative irradiation has been used to produce tumor regression and allow complete resection of rectal cancer with a sphincter-saving procedure. to evaluate the associated toxicity, the response in the primary tumor, and the postsurgical morbidity in a group of patients with locally advanced rectal cancer treated with preoperative chemoradiation therapy and low anterior resection, 120 patients were treated with 45 gy of preoperative radiotherapy and a bolus infusion of 5-fluorouracil 450 mg/m ... | 2001 | 11571965 |
| parotid gland carcinoma: surgical strategy based on local risk factors. | to evaluate the best surgical strategy in cases of parotid gland carcinoma, local risk factors (t, n, histology, and treatment) were analyzed in a series of 134 patients. the efficacy of the facial nerve sacrifice in case of macroscopic tumor infiltration was tested by means of survival analyses (kaplan-meier and cox algorithms). this study demonstrated that nerve preservation resulted in a better prognostic value when compared with resection only in the group of patients having a t1 or t2. in p ... | 2001 | 11572247 |
| thyroid function and aging: gender-related differences. | the effects of aging on human or animal thyroid function are still not well defined. we evaluated some aspects of thyroid function during aging using an animal model (young and old dutch-miranda rats). in old rats of both genders, serum thyroxine (t4) decreased but serum thyrotrophin (tsh) remained unaltered, suggesting a disturbance in the pituitary-thyroid feedback mechanism during aging. serum tri-iodothyronine (t3) only decreased in old males, possibly because female rats are almost twice as ... | 2001 | 11572803 |
| a study of insulin resistance in subjects with acanthosis nigricans. | to study the prevalence of insulin resistance (ir) and its sequelae in patients with acanthosis. | 2001 | 11573555 |
| infusion of amino acid enriched solution hastens recovery from neuromuscular block caused by vecuronium. | we investigated the effect of an amino acid infusion on neuromuscular block produced by vecuronium, and on rectal temperature and surface temperature over the adductor pollicis muscle. sixty adult patients undergoing general anaesthesia were randomly divided into four groups of 15 patients each: amino acid (aa)-post-tetanic count (ptc); aa-train-of-four (tof); control (c)-ptc; or c-tof group. in the aa-ptc and aa-tof groups, after a bolus of vecuronium 0.1 mg kg(-1), a continuous infusion of an ... | 2001 | 11573589 |
| rate of injection through whitacre needles affects distribution of spinal anaesthesia. | a prospective, randomized, double-blind study was performed to investigate whether altering the rate of injection of local anaesthetic through a whitacre needle had any effect on the spinal block achieved. twenty patients scheduled for elective urological surgery under spinal anaesthesia received an injection of 3 ml of 0.5% plain bupivacaine either by hand (fast) over 10 s (18 ml min(-1)) or by infusion pump (slow) over 3 min (1 ml min(-1)). all patients were in the sitting position both during ... | 2001 | 11573668 |
| treatment of inoperable stage iii and iv non-small-cell lung cancer: the 'average' radiotherapist's point of view. | stage iii non-small-cell lung cancer (nsclc) presents a major therapeutic problem for the radiation oncologist who treats patients outside of clinical trials. it is a heterogeneous disease with great variation of the clinical extent, and the optimal therapeutic decision must be based on various parameters: the most important unfavorable characteristics are represented by a low karnofsky performance status, weight loss > 5%, locally too advanced disease (e.g. t4, positive pleural effusion), inten ... | 2001 | 11574760 |
| hemodynamic and catecholamine responses to laryngoscopy and tracheal intubation in patients with complete spinal cord injuries. | endotracheal intubation in patients undergoing general anesthesia often causes hypertension and tachycardia, which may be altered when the efferent sympathetic fiber to the cardiovascular system is interrupted. the aim of the current study was to investigate the effects of different levels of spinal cord injury on the cardiovascular responses to intubation. | 2001 | 11575537 |
| genotyping of simple and compound short tandem repeat loci using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. | the utility of electrospray ionization fourier transform ion cyclotron resonance (esi-fiicr) mass spectrometry as a new approach for genotyping short tandem repeats (strs) is demonstrated. strs are currently valued as a powerful source of genetic information with repeats that range in structure from simple to hypervariable. two tetranucleotide str loci were chosen to evaluate esi-fticr mass spectrometry as a tool for genotyping: hum-th01, a simple str with nonconsensus alleles, and vwa, a compou ... | 2001 | 11575801 |
| thyroxine and illness severity in very low-birth-weight infants. | the objective of this study was to determine the relationship between thyroxine (t4) and illness severity in a population of preterm infants. we investigated a cohort of infants with birth weights 1,500 g or less from a single level iii neonatal intensive care unit who received a minimum of one cranial sonogram to screen for intraventricular hemorrhage (ivh) and one newborn screen for t4 during a 2-year period, (n = 284). the score for neonatal acute physiology (snap) was used to measure illness ... | 2001 | 11575857 |
| severe thyrotoxicosis induced by thyroid metastasis of lung adenocarcinoma: a case report and review of the literature. | a 50-year-old woman who had undergone lung lobectomy because of lung adenocarcinoma presented with thyrotoxicosis, neck swelling, and cervical lymphadenopathy one month after the operation. the total serum triiodothyronine (t3) and thyroxine (t4) levels were markedly elevated to 514 ng/dl and 26.4 microg/dl, respectively, and serum thyrotropin (tsh) was suppressed to less than 0.005 microu/ml. although the thyroid gland had been normal before surgery, chest computed tomography (ct) scan revealed ... | 2001 | 11575859 |
| hemofiltration reduces the serum priming activity on neutrophil chemiluminescence in septic patients. | priming of the polymorphonuclear neutrophil (pmn) response has been implicated in the activation of oxidative burst and tissue injury in patients with septic shock and acute renal failure (arf). this study evaluated whether hemofiltration (hf) removes substances able to enhance the oxidative burst of pmns. | 2001 | 11576379 |
| [primary hypothyroidism in the adult older than 60 years. characteristics and follow-up after initiation of replacement treatment in hospital]. | primary hypothyroidism is common in the elderly. yet its care remains unclear. | 2001 | 11577594 |