Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| emergence of ndm-1-positive capsulated escherichia coli with high resistance to serum killing in japan. | the new delhi metallo-+¦-lactamase-1 (ndm-1) gene, bla (ndm-1), is an emerging plasmid-borne drug resistance gene, which encodes for exceptionally broad-spectrum +¦-lactamase, being able to hydrolyze a wide variety of +¦-lactams, including carbapenems, and was first reported in klebsiella pneumoniae from a swedish patient of indian origin in 2009. it is widely distributed among enterobacteriacae and has geographically exhibited extremely rapid and global spread. in this study, we characterized t ... | 2011 | 21437680 |
| treatment and outcomes in carbapenem-resistant klebsiella pneumoniae bloodstream infections. | carbapenem-resistant klebsiella pneumoniae (cr-kp) is an emerging multidrug-resistant nosocomial pathogen. this is a retrospective chart review describing the outcomes and treatment of 60 cases of cr-kp bloodstream infections. all cr-kp isolated from blood cultures were identified retrospectively from the microbiology laboratory from january 2007 to may 2009. clinical information was collected from the electronic medical record. patients with 14-day hospital mortality were compared to those who ... | 2011 | 21396529 |
| evaluation of antimicrobial susceptibility for +¦-lactams against clinical isolates from 51 medical centers in japan (2008). | this antimicrobial resistance surveillance study was performed in 51 medical centers in japan over an 11-year period. the susceptibilities of 4228 strains including escherichia coli (491 strains), klebsiella spp. (462 strains), enterobacter spp. (459 strains), citrobacter freundii (358 strains), indole-positive proteus spp. (386 strains), serratia spp. (443 strains), acinetobacter spp. (327 strains), pseudomonas aeruginosa (473 strains), oxacillin-susceptible staphylococcus aureus (481 strains), ... | 2011 | 21396543 |
| molecular epidemiology of kpc-2- producing klebsiella pneumoniae isolates in brazil: the predominance of sequence type 437. | the aim of this study was to investigate the genetic relatedness of 57 kpc-2-producing klebsiella pneumoniae isolates from 5 states in brazil, during 2006-2009. pulse-field gel electrophoresis analysis identified 10 pulsotypes. the pulsotype designated as kp-rj (klebsiella pneumoniae-rio de janeiro) was the dominant clone found in the states of rio de janeiro and esp+¡rito santo. multilocus sequence typing of kp-rj assigned it to st 437. sequence types st11, st16, st25, st70, st101, st105, st423 ... | 2011 | 21397425 |
| prevalence and contributing factors of nonsusceptibility to imipenem or meropenem in extended-spectrum +¦-lactamase-producing klebsiella pneumoniae and escherichia coli. | among the extended-spectrum +¦-lactamase (esbl)-producing klebsiella pneumoniae and escherichia coli, 3.9% of k. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of esbl and/or plasmid-mediated ampc +¦-lactamase production and porin loss. the presence of bla(ctx-m-14) and loss of ompk36 were associated with higher carbapenem mics. | 2011 | 21397426 |
| carbapenem therapy for bacteremia due to extended-spectrum +¦-lactamase-producing escherichia coli or klebsiella pneumoniae. | for 244 patients with bacteremia due to extended-spectrum +¦-lactamase (esbl)-producing escherichia coli or klebsiella pneumoniae treated by ertapenem (73, 29.9%) or either imipenem or meropenem (171, 70.1%), the therapeutic efficacy was evaluated. ertapenem therapy was effective for patients with esbl-producing e. coli or k. pneumoniae bacteremia in terms of mortality and microbiological responses, as compared with imipenem or meropenem. | 2011 | 21398070 |
| emergence of ndm-1-producing acinetobacter baumannii in china. | to investigate the prevalence of bla(ndm-1) in gram-negative bacilli in china. | 2011 | 21398294 |
| spatiotemporal development of the bacterial community in a tubular longitudinal microbial fuel cell. | the spatiotemporal development of a bacterial community in an exoelectrogenic biofilm was investigated in sucrose-fed longitudinal tubular microbial fuel cell reactors, consisting of two serially connected modules. the proportional changes in the microbial community composition were assessed by polymerase chain reaction-denaturing gradient gel electrophoresis (dgge) and dna sequencing in order to relate them to the performance and stability of the bioelectrochemical system. the reproducibility o ... | 2011 | 21400098 |
| role of shv ß-lactamase variants in resistance of clinical klebsiella pneumoniae strains to ß-lactams in an algerian hospital. | three clinical klebsiella pneumoniae strains, kparg74, kparg220 and kparg185, isolated from a hospital in algeria, carried the novel ß-lactamases shv-98, shv-99 and shv-100, respectively, and co-expressed tem-1 and either ctx-m-3 or ctx-m-15. in contrast, transformed cells possessing the genes for these novel ß-lactamases, i.e. ecdh5a-shv-98, ecdh5a-shv-99 and ecdh5a-shv-100, respectively, carried unique sequence features of bla(shv) gene variants, enabling oxyimino-cephalosporin susceptibility ... | 2011 | 21415202 |
| comparison of the diversity of the bacterial communities in the intestinal tract of adult bactrocera dorsalis from three different populations. | to (i) identify the bacterial communities in the gut of oriental fruit fly (bactrocera dorsalis) adult and (ii) determine whether the different surroundings and diets influence the bacteria composition. | 2011 | 21395953 |
| prevalence of ß-lactamases and 16s rrna methylase genes amongst clinical klebsiella pneumoniae isolates carrying plasmid-mediated quinolone resistance determinants. | to characterise the prevalence of ß-lactamases and 16s rrna methylase genes amongst clinical klebsiella pneumoniae isolates carrying plasmid-mediated quinolone resistance (pmqr) determinants in china, 59 non-duplicate k. pneumoniae isolates harbouring at least one pmqr gene were screened for common ß-lactamases and 16s rrna methylases genes. the genetic relatedness of the isolates was analysed by pulsed-field gel electrophoresis (pfge). most of pmqr gene-positive isolates carried no substitution ... | 2011 | 21376540 |
| assessment of hypermucoviscosity as a virulence factor for experimental klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. | klebsiella pneumoniae displaying the hypermucoviscosity (hv) phenotype are considered more virulent than hv-negative strains. nevertheless, the emergence of tissue-abscesses-associated hv-negative isolates motivated us to re-evaluate the role of hv-phenotype. | 2011 | 21385400 |
| characterization of n-acylhomoserine lactone-degrading bacteria associated with the zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in acinetobacter and burkholderia. | cell-to-cell communication (quorum sensing (qs)) co-ordinates bacterial behaviour at a population level. consequently the behaviour of a natural multi-species community is likely to depend at least in part on co-existing qs and quorum quenching (qq) activities. here we sought to discover novel n-acylhomoserine lactone (ahl)-dependent qs and qq strains by investigating a bacterial community associated with the rhizosphere of ginger (zingiber officinale) growing in the malaysian rainforest. | 2011 | 21385437 |
| extended-spectrum beta-lactamase-producing bacterial infections in adult solid organ transplant recipients. | limited research is available evaluating infections due to extended-spectrum +¦-lactamase (esbl)-producing organisms in adult recipients of solid organ transplant (sot). | 2011 | 21386016 |
| antimicrobial susceptibility profiles of aerobic and facultative gram-negative bacilli isolated from patients with intra-abdominal infections in the asia-pacific region according to currently established susceptibility interpretive criteria. | the study for monitoring antimicrobial resistance trends (smart) was intended to reveal the evolving profiles of antimicrobial resistance among gram-negative pathogens causing intra-abdominal infections (iais) from asia-pacific region in 2009. | 2011 | 21382411 |
| high burden of antimicrobial resistance in asia. | antimicrobial resistance is associated with high mortality rates and high medical costs. marked variations in the resistance profiles of bacterial and fungal pathogens as well as the quality of public hygiene have had a considerable impact on the effectiveness of antimicrobial agents in asian countries. in asia, one of the epicentres of antimicrobial drug resistance, there is an alarming number of antibiotic-resistant species, including penicillin- and erythromycin-resistant streptococcus pneumo ... | 2011 | 21382699 |
| rapid increase of carbapenemase-producing klebsiella pneumoniae strains in a large italian hospital: surveillance period 1 march - 30 september 2010. | the first case of carbapenemase-producing enterobacteriaceae in italy was reported in 2009. we performed a study over a period of seven months in 2010 to survey the circulation of klebsiella pneumoniae carbapenemases (kpc) ina 1,500-bed university hospital in northern italy and report the presence and rapid increase of these multidrug-resistant bacteria. the results raise a major concern about these pathogens and demonstrate the urgent need for infection control and antibiotic stewardship progra ... | 2011 | 21371414 |
| [mortality risk factors for bloodstream infections caused by extended-spectrum beta-lactamase-producing microorganisms]. | to identify risk factors for mortality in patients with bloodstream infection by extended-spectrum beta-lactamase (esbl)-producing microorganisms. | 2011 | 21371702 |
| microbiological profile of haematogenous osteoarticular infections in children. | introduction: staphylococcus aureus, kingella kingae and ß-hemolytic streptococcus are presently the most frequently identified bacteria in child haematogenous osteoarticular infection. objective: to determine the microbiological profile (bacteria and antibiotic susceptibility) of osteoarticular infections in a paediatric hospital, so as to adapt treatment protocols to the ecology of the bacteria isolated. patients and methods: prospective descriptive study, including children admitted for acute ... | 2011 | 21371961 |
| evaluation of a commercial multiplex pcr test (septifast) in the etiological diagnosis of community-onset bloodstream infections. | the commercial polymerase chain reaction (pcr) test, septifast, is designed to identify the dna of individual bacterial and fungal pathogens in whole blood. we aimed to evaluate the usefulness of the test for the detection of community-onset bloodstream infections. we prospectively included adult patients who were subjected to blood culture (bc) at an infectious diseases department. for the evaluation, one bc/pcr set (two bc bottles and one pcr tube) per patient was used. when several sets were ... | 2011 | 21373774 |
| facultative methylotrophs from the human oral cavity and methylotrophy in strains of gordonia, leifsonia, and microbacterium. | we show that bacteria with methylotrophic potential are ubiquitous in the human mouth microbiota. numerous strains of actinobacteria (brevibacterium, gordonia, leifsonia, microbacterium, micrococcus, rhodococcus) and proteobacteria (achromobacter, klebsiella, methylobacterium, pseudomonas, ralstonia) were isolated, and one strain of each of the eleven genera was studied in detail. these strains expressed enzymes associated with methylotrophic metabolism (methanol, methylamine, and formate dehydr ... | 2011 | 21374057 |
| [prognostic impact of extended-spectrum beta-lactamases (esbl)]. | 2011 | 21367407 | |
| foodborne nosocomial outbreak of shv1 and ctx-m-15-producing klebsiella pneumoniae: epidemiology and control. | we describe a foodborne nosocomial outbreak due to extended-spectrum ß-lactamase (esbl)-producing klebsiella pneumoniae. | 2011 | 21367727 |
| comparison of polymyxin b, tigecycline, cefepime, and meropenem mics for kpc-producing klebsiella pneumoniae by broth microdilution, vitek 2, and etest. | we report mic agreement and error rates between broth microdilution (bmd), vitek 2, and etest against 48 clinical kpc-producing klebsiella pneumoniae isolates for polymyxin b, tigecycline, cefepime, and meropenem. both commercial testing methods were useful for tigecycline testing; etest provided a conservative estimate of polymyxin b susceptibility. we suggest that laboratories consider the supplemental use of reference bmd or etest for cefepime and meropenem for susceptibility testing of kpc-p ... | 2011 | 21367993 |
| clinical and microbiological evaluation of hemodialysis-associated pneumonia (hdap): should hdap be included in healthcare-associated pneumonia? | although hemodialysis-associated pneumonia (hdap) was included among the healthcare-associated pneumonias (hcap) in the 2005 american thoracic society (ats)/infectious diseases society of america (idsa) guideline, little information relevant to clinical epidemiology, especially microbiological characteristics, is available. this study aimed to reveal microbiological characteristics and clinical outcomes of hdap and to assess whether hdap should be included in the hcap category. we retrospectivel ... | 2011 | 21369775 |
| microbiology and antibiotic susceptibility of organisms in bile cultures from patients with and without cholangitis at an asian academic medical center. | to review the epidemiology of microbial isolates from bile cultures taken from patients with and without cholangitis admitted to an asian academic medical center in order to compare antimicrobial sensitivities and to make recommendations for empiric antimicrobial therapy of patients with cholangitis in the philippines. | 2011 | 21348769 |
| phylogenetic groups among klebsiella pneumoniae isolates from brazil: relationship with antimicrobial resistance and origin. | the objectives of this study were to determine the distribution of phylogenetic groups among klebsiella pneumoniae isolates from recife, brazil and to assess the relationship between the groups and the isolation sites and resistance profile. ninety four isolates of k. pneumoniae from hospital or community infections and from normal microbiota were analyzed by gyra pcr-rflp, antibiotic susceptibility, and adonitol fermentation. the results revealed the distinction of three phylogenetic groups, as ... | 2011 | 21350801 |
| real-time pcr assay and a synthetic positive control for the rapid and sensitive detection of the emerging resistance gene new delhi metallo-ß-lactamase-1 (bla(ndm-1)). | carbapenems are important last-line antibiotics for the treatment of hospital infections. enterobacteriaceae (such as klebsiella pneumoniae or escherichia coli) expressing the "new delhi metallo-ß-lactamase" gene bla(ndm-1) are resistant to carbapenems and were predicted to become a major global health problem. to cope with this emerging threat, there is a need for rapid and sensitive molecular assays to detect bla(ndm-1) in carbapenem-resistant enterobacteriaceae from clinical isolates. in diag ... | 2011 | 21350860 |
| prevalence and characteristics of ertapenem-resistant klebsiella pneumoniae isolates in a taiwanese university hospital. | this study was conducted to investigate the prevalence and characteristics of ertapenem-resistant (etp-r) klebsiella pneumoniae isolates at a taiwanese hospital. the disk-diffusion tests revealed that the rate of ertapenem resistance among all isolates collected in 2008 was 13.5%, and the resistance rate among bloodstream isolates increased from 0% to 13.6% between 2001 and 2008. eighty-two nonduplicate etp-r isolates collected in 2008 were examined. seventy-four (90.2%) isolates of them had ext ... | 2011 | 21352075 |
| broad-spectrum antimicrobial efficacy of peptide a3-apo in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved. | although the designer proline-rich antimicrobial peptide a3-apo has only modest activity against escherichia coli and acinetobacter baumannii in vitro, in mouse models of systemic and wound infections it shows superior efficacy compared with conventional antibiotics. in this study, the efficacy of a3-apo in several additional mouse models was investigated, including staphylococcus aureus wound infection, mixed klebsiella pneumoniae-a. baumannii-proteus mirabilis wound infection and k. pneumoniae ... | 2011 | 21353493 |
| prevalence of antimicrobial resistant pathogens from blood cultures from canadian hospitals: results of the canward 2007-2009 study. | this study assessed the epidemiology and antimicrobial resistance of pathogens associated with bloodstream infections in canadian hospitals between 2007 and 2009. tertiary-care medical centers representing 8 of 10 canadian provinces submitted bloodstream infection pathogens from patients attending hospital clinics, emergency rooms, medical/surgical wards, and intensive care units. over 8,000 blood culture pathogens were collected. the 10 most common pathogens (representing 80.9% of all isolates) ... | 2011 | 21353958 |
| in vitro activity of ceftobiprole against frequently encountered aerobic and facultative gram-positive and gram-negative bacterial pathogens: results of the canward 2007-2009 study. | the in vitro activity of ceftobiprole was evaluated against 15 011 clinical isolates obtained from patients in canadian hospitals between 2007 and 2009. all staphylococcus aureus were susceptible to ceftobiprole (mic(90)'s for methicillin-susceptible staphylococcus aureus and methicillin-resistant staphylococcus aureus of = 1 µg/ml and 2 µg/ml, respectively). ceftobiprole was active against penicillin-susceptible streptococcus pneumoniae (mic(90), = 0.06 µg/ml), penicillin-resistant streptococcu ... | 2011 | 21353964 |
| spontaneous eradication of a ndm-1 positive klebsiella pneumoniae that colonized the intestine of an asymptomatic carrier. | 2011 | 21354091 | |
| activity of nxl104 in combination with beta-lactams against genetically characterized escherichia coli and klebsiella pneumoniae isolates producing class a extended-spectrum beta-lactamases and class c beta-lactamases. | the novel non-ß-lactam ß-lactamase inhibitor nxl104, in combination with cefepime, ceftazidime, ceftriaxone, amdinocillin, and meropenem, was tested against 190 extended-spectrum ß-lactamase (esbl)-producing escherichia coli and klebsiella pneumoniae isolates, 94 ampc-hyperproducing e. coli isolates, and 8 ampc/esbl-coexpressing e. coli isolates. nxl104 restored 100% susceptibility to the partner cephalosporins for all isolates tested. amdinocillin and meropenem mics were modestly improved (2 to ... | 2011 | 21357295 |
| transcriptional regulation of the gene cluster encoding allantoinase and guanine deaminase in klebsiella pneumoniae. | purines can be used as the sole source of nitrogen by several strains of k. pneumoniae under aerobic conditions. the genes responsible for the assimilation of purine nitrogens are distributed in three separated clusters in the k. pneumoniae genome. here, we characterize the cluster encompassing genes kpn_01787 to kpn_01791, which is involved in the conversion of allantoin into allantoate and in the deamination of guanine to xanthine. these genes are organized in three transcriptional units, hpxs ... | 2011 | 21357483 |
| confirmation of hiv-like sequences in respiratory tract bacteria of cambodian and kenyan hiv-positive pediatric patients. | bacteria and yeasts isolated from respiratory tracts of 39 cambodian and 28 kenyan hiv-positive children were tested for the presence of hiv-1 sequences. | 2011 | 21358602 |
| prevalence of fecal carriage of extended-spectrum ß-lactamase-producing enterobacteriaceae among healthy adult people in japan. | in japan, the prevalence of extended-spectrum ß-lactamase (esbl) producers in hospital settings has shown an increasing trend. in the present study, we investigated the prevalence of the fecal carriage of esbl-producing enterobacteriaceae among healthy adults. stool samples were collected for the phenotypic and genotypic identification of esbl-producing enterobacteriaceae. we found the prevalence of esbl producers to be 6.4% by phenotypic identification, and 92.9% of them possessed the bla (ctx- ... | 2011 | 21359543 |
| prevalence of the bla (shv) gene in klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in recife, brazil. | the aim of this study was to determine the prevalence of the bla (shv) gene in klebsiella pneumoniae isolates from hospital and community infections and from the normal microbiota of healthy individuals in recife, pe, brazil. fifty-two k. pneumoniae isolates were analyzed regarding the presence of the bla (shv) gene, using pcr, and eight isolates were analyzed by dna sequencing. this gene was detected in 16 isolates from hospital infections, four from community infections, and nine from the norm ... | 2011 | 21359845 |
| antibiotic adjuvants: multicomponent anti-infective strategies. | the unremitting emergence of multidrug-resistant bacterial pathogens highlights a matching need for new therapeutic options. for example, new carbapenemases such as kpc (class a klebsiella pneumoniae) and ndm-1 (new delhi metallo-ß-lactamase 1) are surfacing, resulting in almost total resistance to ß-lactam antibiotics. furthermore, resistance is quickly disseminated, not only in the healthcare sector, but also within the community at large, because many resistance determinants are carried on mo ... | 2011 | 21342612 |
| outbreak of oxa-48-positive carbapenem-resistant klebsiella pneumoniae isolates in france. | seventeen klebsiella pneumoniae isolates producing the oxa-48 carbapenemase, obtained from 10 patients hospitalized from april to june 2010, mostly in the medical intensive care unit of the villeneuve-saint-georges hospital in a suburb of paris, france, were analyzed. seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the blaoxa-48 ... | 2011 | 21343451 |
| multistep resistance development studies of ceftaroline in gram-positive and -negative bacteria. | ceftaroline, the active component of the prodrug ceftaroline fosamil, is a novel broad-spectrum cephalosporin with bactericidal activity against gram-positive and -negative isolates. this study evaluated the potential for ceftaroline and comparator antibiotics to select for clones of streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae, moraxella catarrhalis, klebsiella pneumoniae, staphylococcus aureus, and enterococcus faecalis with elevated mics. s. pneumoniae and s. pyoge ... | 2011 | 21343467 |
| diarrheagenic escherichia coli in acute gastroenteritis in infants in north-west italy. | enteropathogenic escherichia coli may cause diarrhoea in infancy, but it is not routinely detected and regarded as a major causative agent. the aim of the present study was to estimate the incidence of enteropathogenic e. coli infection and to investigate its epidemiology and pathogenesis from faecal specimens in infants hospitalized for acute gastroenteritis. between march 2008 and june 2009, faecal samples were collected and examined to recognize diarrhoeal aetiology, especially for e. coli, b ... | 2011 | 21344146 |
| metabolism of select amino acids in bacteria from the pig small intestine. | this study investigated the metabolism of select amino acids (aa) in bacterial strains (streptococcus sp., escherichia coli and klebsiella sp.) and mixed bacterial cultures derived from the jejunum and ileum of pigs. cells were incubated at 37°c for 3 h in anaerobic media containing 0.5-5 mm select aa plus [u-(14)c]-labeled tracers to determine their decarboxylation and incorporation into bacterial protein. results showed that all types of bacteria rapidly utilized glutamine, lysine, arginine an ... | 2011 | 21344175 |
| synthesis and antibacterial evaluation of novel 8-fluoro norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant staphylococcus aureus. | a series of novel 8-fluoro norfloxacin derivatives and the hybrids of its piperazinyl derivatives incorporated with 1,3,5-triazine and pyrimidine were synthesized. all the above compounds were evaluated for their antibacterial activity against klebsiella pneumoniae, methicillin-resistant staphylococcus aureus and methicillin & vancomycin-resistant s. aureus. among all, compounds having morpholine, n-methyl/phenyl/benzyl/pyrimidinyl piperazines and n-butylamine substitution at c-7 position, have ... | 2011 | 21345548 |
| phenotypic and genotypic screening and clonal analysis of carbapenem-resistant klebsiella pneumoniae at a single hospital. | detection of bla(kpc)-harboring klebsiella pneumoniae (kp) in the clinical laboratory remains a difficult task. decreased ertapenem (ert) susceptibility has been considered one of the most sensitive phenotypic indicators of k. pneumoniae carbapenemase (kpc) production, but has been found to be nonspecific. susceptibility testing using imipenem or meropenem lacks the sensitivity for detection of kpcs, and there is limited experience using doripenem (dor). fifty-five individual ert-nonsusceptible ... | 2011 | 21332362 |
| [microbiological profile of infections in the intensive care units of colombia (episepsis colombia]. | valid and reliable data regarding sepsis is lacking in colombia. our aim was to determine the prevalence of the microorganisms in the main infections treated in intensive care units (icus) in our country. | 2011 | 21334104 |
| symptomatic secondary vesical calculus formed on an intrauterine contraceptive device inserted 25 years previously. | a 57-year-old postmenopausal woman presented with vague lower abdominal symptoms, dysuria and recurrent urinary tract infection of a year's duration. she had an intrauterine contraceptive device (iucd) inserted 25 years previously and denied having any significant gynecological or urinary tract symptoms since the device was inserted. ct scan of her pelvis confirmed the presence of an iucd that had migrated into the urinary bladder and on which a calculus had formed. an attempt at removal of the ... | 2011 | 21335943 |
| degradation of tannic acid by cold-adapted klebsiella sp nacasa1 and phytotoxicity assessment of tannic acid and its degradation products. | the focus of the present study is to know the potential of bacterial isolate for tannic acid degradation at low temperature. also, we tried to evaluate the suitability of phytotoxicity testing protocol for the determination of tannic acid toxicity. | 2011 | 21336632 |
| development of recombinant klebsiella pneumoniae ∆dhat strain for the co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol. | klebsiella pneumoniae converts glycerol to the specialty chemical 1,3-propanediol (1,3-pdo), which is used for the production of polytrimethylene terepthalate (ptt). in this study, an nad(+)-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (puuc) of k. pneumoniae dsm 2026, which oxidizes 3-hydroxypropionaldehyde to a platform chemical 3-hydroxypropionic acid (3-hp), was cloned and overexpressed in k. pneumoniae dsm 2026 for the co-production of 3-hp and 1,3-pdo from glycerol. in a ... | 2011 | 21336929 |
| molecular characterization of antimicrobial resistance in gram-negative bacteria isolated from bovine mastitis in egypt. | the aim of this study was to characterize the genetic basis of multidrug resistance in gram-negative bacteria isolated from bovine mastitis cases in egypt. multidrug resistance phenotypes were found in 34 of 112 (30.4%) gram-negative bacterial isolates, which harbored at least one antimicrobial resistance gene. the most prevalent multidrug-resistant (mdr) species were enterobacter cloacae (8 isolates, 7.1%), klebsiella pneumoniae (7 isolates, 6.3%), klebsiella oxytoca (7 isolates, 6.3%), escheri ... | 2011 | 21338385 |
| sorting of an integral outer membrane protein via the lipoprotein-specific lol pathway and a dedicated lipoprotein pilotin. | the lipoprotein puls is a dedicated chaperone that is required to target the secretin puld to the outer membrane in klebsiella or escherichia coli, and to protect it from proteolysis. here, we present indirect evidence that puld protomers do not assemble into the secretin dodecamer before they reach the outer membrane, and that puls reaches the outer membrane in a soluble heterodimer with the general lipoprotein chaperone lola. however, we could not find any direct evidence for puld protomer ass ... | 2011 | 21338419 |
| riding the trojan horse: combating pest insects with their own symbionts. | insects form an extremely large group of animals and bear a consequently large variety of associated microbes. this microbiota includes very specific and obligate symbionts that provide essential functions to the host, and facultative partners that are not necessarily required for survival. the tephritidae is a large family that includes many fruit pests such as the mediterranean fruit fly (the medfly, ceratitis capitata) and the olive fly (bactrocera oleae). community and functional analyses sh ... | 2011 | 21338477 |
| a new cost-effective, selective and differential medium for the isolation of cronobacter spp. | the objective of the present study was to develop a new selective, differential and cost-effective medium (kim and rhee - kr-medium) for the isolation of cronobacter spp. in this new medium, which contained salicin as a differential agent, cronobacter spp. generated typical colonies with characteristic violet-colored centers surrounded by a transparent to opalescent border, and the growth of other microorganisms (40 strains) was inhibited or produced visually distinguishable colonies. using heal ... | 2011 | 21338629 |
| investigation of pulmonary infection pathogens in neurological intensive care unit. | the purpose of this study is to investigate the distribution and antimicrobial susceptibility of pathogenic bacteria in inpatients with pulmonary infection in the neurological intensive care unit (nicu). | 2011 | 21339939 |
| [investigation of the susceptibilities of extended-spectrum beta-lactamase-producing escherichia coli and klebsiella spp. strains to ertapenem and other carbapenems]. | infections caused by extended-spectrum beta-lactamase (esbl) producing escherichia coli and klebsiella spp. constitute severe problems. carbapenems are commonly used to treat these infections. however, infections caused by carbapenem-resistant gram-negative bacteria show an increasing trend recently. the aim of this study was to investigate the susceptibilities of esbl-producing e.coli and klebsiella spp. to ertapenem and other carbapenems. a total of 239 e.coli, 28 k.pneumoniae and 11 k.oxytoca ... | 2011 | 21341156 |
| [causative agents of intravenous catheter-related infections and their antibiotic susceptibilities]. | intravenous catheterization can lead to colonization as well as a broad spectrum of infections ranging from catheter site infections to catheter-related blood stream infections (crbsis). the aim of this study was to evaluate the distribution of causative agents and their antibiotic susceptibility patterns in crbsis and catheter site infections along with the colonization rates and colonizing microorganisms in zonguldak karaelmas university hospital, turkey. the results of cultures from catheter ... | 2011 | 21341163 |
| [escherichia coli-induced emphysematous pyelonephritis in a diabetic patient with polycystic kidney disease]. | emphysematous pyelonephritis is a rare, necrotizing infection of the kidney and the perirenal space resulting in the formation of gas in both structures and associated with a high mortality rate. in 90% of cases it affects one kidney only; in the remaining 10% with bilateral emphysematous pyelonephritis aggressive surgical intervention may be required. women are much more frequently affected than men, with diabetes mellitus (in 70-90% of cases) and urinary tract obstruction being common predispo ... | 2011 | 21341250 |
| antibacterial activity of the indigenous earthworms lampito mauritii (kinberg) and perionyx excavatus (perrier). | earthworms respond to microbial infection through cellular and humoral defense mechanisms such as antimicrobial protein secretions. most of the humoral defense proteins are synthesized in the skin itself. | 2011 | 21299431 |
| a multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis. | antimicrobial resistance is a global problem and the prevalence is high in many asian countries. | 2011 | 21299688 |
| multiresistant gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. | multilocus sequence typing reveals that many bacterial species have a clonal structure and that some clones are widespread. this underlying phylogeny was not revealed by pulsed-field gel electrophoresis, a method better suited to short-term outbreak investigation. some global clones are multiresistant and it is easy to assume that these have disseminated from single foci. such conclusions need caution, however, unless there is a clear epidemiological trail, as with kpc carbapenemase-positive kle ... | 2011 | 21303394 |
| first case of resistance to tigecycline by klebsiella pneumoniae in a european university hospital. | 2011 | 21304206 | |
| act-6, a novel plasmid-encoded class c ß-lactamase in a klebsiella pneumoniae isolate from china. | the purpose of this study was to investigate the phenotypic and molecular characterization of a novel plasmid-mediated ampc-type ß-lactamase in klebsiella pneumoniae e701 isolated from anhui province in china. in comparison with the act-1, sequence analysis revealed that there were 43 point mutations in the coding gene, and 10 of which led to amino-acid substitution. resistance could be transferred by conjugation or transformation with plasmid dna into e. coli jm109, which was due to the product ... | 2011 | 21304534 |
| identification of pantoea ananatis gene encoding membrane pyrroloquinoline quinone (pqq)-dependent glucose dehydrogenase and pqqabcdef operon essential for pqq biosynthesis. | pantoea ananatis accumulates gluconate during aerobic growth in the presence of glucose. computer analysis of the p. ananatis sc17(0) sequenced genome revealed an orf encoding a homologue (named gcd) of the mgdh (ec 1.1.99.17) apoenzyme from escherichia coli and a putative pyrroloquinoline quinone (pqq) biosynthetic operon homologous to pqqabcdef from klebsiella pneumoniae. construction of ?gcd and ?pqq mutants of p. ananatis confirmed the proposed functions of these genetic elements. the p. ana ... | 2011 | 21306430 |
| the prevention of biofilm colonization by multidrug-resistant pathogens that cause ventilator-associated pneumonia with antimicrobial-coated endotracheal tubes. | ventilator-associated pneumonia (vap) continues to be the nosocomial infection associated with the highest mortality in critically ill patients. since silver-coated endotracheal tubes (ett) was shown in a multicenter prospective randomized trials to decrease the risk of vap, we compared the efficacy of two antiseptic agents such as gardine- and gendine-coated etts with that of silver-coated etts in preventing biofilm. the etts were tested for their ability to prevent the biofilm formation of met ... | 2011 | 21295343 |
| prevalence and phenotypic characterisation of carbapenem resistance in enterobacteriaceae bloodstream isolates in a tertiary care hospital in india. | 2011 | 21295949 | |
| altering the composition of caseicins a and b as a means of determining the contribution of specific residues to antimicrobial activity. | caseicin a (ikhqglpqe) and caseicin b (vlnenllr) are antimicrobial peptides generated through the bacterial fermentation of sodium caseinate, and on the basis of this and previous studies, they are active against many gram-negative pathogens (cronobacter sakazakii, cronobacter muytjensii, salmonella enterica serovar typhimurium, escherichia coli, klebsiella pneumoniae, and pseudomonas fluorescens) as well as the gram-positive organism staphylococcus aureus. here we describe further studies with ... | 2011 | 21296933 |
| an experimentally validated genome-scale metabolic reconstruction of klebsiella pneumoniae mgh 78578, iyl1228. | klebsiella pneumoniae is a gram-negative bacterium of the family enterobacteriaceae that possesses diverse metabolic capabilities: many strains are leading causes of hospital-acquired infections that are often refractory to multiple antibiotics, yet other strains are metabolically engineered and used for production of commercially valuable chemicals. to study its metabolism, we constructed a genome-scale metabolic model (iyl1228) for strain mgh 78578, experimentally determined its biomass compos ... | 2011 | 21296962 |
| synthesis, characterization and biological evaluation of mononuclear co(ii), ni(ii), cu(ii) and pd(ii) complexes with new n2o2 schiff base ligands. | new tetradentate n(2)o(2) donor schiff bases and their mononuclear co(ii), ni(ii), cu(ii), and pd(ii) complexes were synthesized and characterized extensively by ir, (1)h-, (13)c-nmr, mass, esr, conductivity measurements, elemental and thermal analysis. specifically the magnetic and electronic spectral measurements demonstrate the octahedral structures of cobalt(ii), nickel(ii) complexes and square planar geometries of copper(ii), palladium(ii) complexes. all the ligands and complexes were scree ... | 2011 | 21297294 |
| thrombocytes are effectors of the innate immune system releasing human beta defensin-3. | thrombocyte concentrate i.e. platelet-rich plasma (prp) has become a popular adjunct for many surgical procedures. it is believed to improve bone and soft tissue healing. recently antimicrobial effects of the autologous preparation were reported by several groups. in this study we investigated the antimicrobial effect of prp against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery. | 2011 | 21310405 |
| bacterial species associated with sound and botrytis-infected grapes from a greek vineyard. | grape bacterial microbiota plays central roles in the quality of grapes and wine, yet its diversity remains poorly described. in the present study, bacterial species associated with sound and botrytis-infected grapes of two cultivars originating from the same vineyard were assessed. isolates were identified by pcr-denaturing gradient gel electrophoresis (pcr-dgge) and sequence analysis of partial 16s rrna gene. comparable counts were recorded between botrytis-infected and sound grape samples. in ... | 2011 | 21315469 |
| antimicrobial drug resistance in taiwan. | antimicrobial resistance is a major global health threat associated with high mortality rates and high medical costs. geographic variations in resistance profiles of bacterial and fungal pathogens have had a considerable impact on antimicrobial prescription. in taiwan, there is an alarmingly high prevalence of penicillin-resistant streptococcus pneumoniae, multidrug-resistant and extensively drug-resistant (xdr) pseudomonas aeruginosa and acinetobacter baumannii, extended-spectrum ß-lactamase-pr ... | 2011 | 21316007 |
| molecular epidemiology and resistance mechanisms involved in reduced susceptibility to amoxicillin/clavulanic acid in klebsiella pneumoniae isolates from a chronic care centre. | the aim of this work was to investigate the molecular epidemiology and mechanisms responsible for reduced susceptibility to amoxicillin/clavulanic acid (amc) amongst cefazolin-susceptible klebsiella pneumoniae isolates from patients admitted to a chronic care institution. in total, 51 (29.8%) of 171 k. pneumoniae isolates recovered between 2006 and 2008 were non-susceptible to amc, of which 45 were susceptible to cefazolin. nucleotide sequencing analysis revealed that 19 produced irt-11 and the ... | 2011 | 21316198 |
| synthesis, stereochemistry, antimicrobial evaluation and qsar studies of 2,6-diaryltetrahydropyran-4-one thiosemicarbazones. | a series of 2,6-diaryltetrahydropyran-4-one thiosemicarbazones (11-27) were synthesized and characterized for evaluation of potential antibacterial activity against staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, salmonella typhi, bacillus subtilis and klebsiella pneumonia and antifungal activity against cryptococcus neoformans, candida albicans, rhizopus sp., aspergillus niger and aspergillus flavus were evaluated. compounds 21 and 22 showed maximum inhibition potency at low co ... | 2011 | 21316819 |
| emergence of klebsiella pneumoniae st258 with kpc-2 in hong kong. | 2011 | 21316928 | |
| containment of a country-wide outbreak of carbapenem-resistant klebsiella pneumoniae in israeli hospitals via a nationally implemented intervention. | during 2006, israeli hospitals faced a clonal outbreak of carbapenem-resistant klebsiella pneumoniae that was not controlled by local measures. a nationwide intervention was launched to contain the outbreak and to introduce a strategy to control future dissemination of antibiotic-resistant bacteria in hospitals. | 2011 | 21317398 |
| enhancement of 2,3-butanediol production by klebsiella oxytoca ptcc 1402. | optimal operating parameters of 2,3-butanediol production using klebsiella oxytoca under submerged culture conditions are determined by using taguchi method. the effect of different factors including medium composition, ph, temperature, mixing intensity, and inoculum size on 2,3-butanediol production was analyzed using the taguchi method in three levels. based on these analyses the optimum concentrations of glucose, acetic acid, and succinic acid were found to be 6, 0.5, and 1.0 (% w/v), respect ... | 2011 | 21318172 |
| splenic abscess: a single institution study and review of the literature. | the aim of this study was to review our experience with splenic abscesses, with respect to the relevant aspects of splenic abscesses and treatment outcomes. | 2011 | 21319348 |
| transport and bacterial interactions of three bacterial strains in saturated column experiments. | the impact of bacteria-solid and bacteria-bacteria interactions on the transport of klebsiella oxytoca, burkholderia cepacia g4pr1, and pseudomonas sp. #5 was investigated in saturated sand column experiments (l = 114 mm; ø = 33 mm) under constant water velocities (~ 5 cm · h(-1)). bacterial strains were injected into the columns as pulses either individually, simultaneously, or successively. a one-dimensional mathematical model for advective-dispersive transport and for irreversible and reversi ... | 2011 | 21319738 |
| rapid genotyping of achromobacter xylosoxidans, acinetobacter baumannii, klebsiella pneumoniae, pseudomonas aeruginosa and stenotrophomonas maltophilia isolates using melting curve analysis of rapd-generated dna fragments (mcrapd). | typing of bacteria is important for monitoring newly emerging pathogens and for examining local outbreaks. we evaluated the randomly amplified polymorphic dna technique in combination with melting curve analysis (mcrapd) of the amplified dna fragments to genotype isolates from five gram-negative species, i.e. achromobacter xylosoxidans, acinetobacter baumannii, klebsiella pneumoniae, pseudomonas aeruginosa and stenotrophomonas maltophilia. by determining the melting temperature peaks of the ampl ... | 2011 | 21320595 |
| high prevalence of kpc-2-type carbapenemase coupled with ctx-m-type extended-spectrum beta-lactamases in carbapenem-resistant klebsiella pneumoniae in a teaching hospital in china. | 2011 | 21321140 | |
| in vitro interactions of antimicrobial combinations with fosfomycin against kpc-2-producing klebsiella pneumoniae and protection of resistance development. | using time-kill methodology, we investigated the interactions of fosfomycin with meropenem or colistin or gentamicin against 17 genetically distinct klebsiella pneumoniae clinical isolates carrying blakpc-2. synergy was observed with meropenem or colistin against 64.7 and 11.8% of tested isolates, while the combination with gentamicin resulted in indifference. all studied combinations showed improved bactericidal activity, compared to fosfomycin alone and prevented the development of fosfomycin ... | 2011 | 21321144 |
| antimicrobial activity of cxa-101, a novel cephalosporin tested in combination with tazobactam against enterobacteriaceae, pseudomonas aeruginosa, and bacteroides fragilis strains having various resistance phenotypes. | cxa-101, a novel oxyimino-aminothiazolyl cephalosporin, cxa-201 (cxa-101 combined with tazobactam), and various comparators were susceptibility tested by broth microdilution methods against 1,301 well-characterized clinical strains collected worldwide, including ceftazidime-resistant members of the family enterobacteriaceae and klebsiella pneumoniae carbapenemase (kpc)- and extended-spectrum ß-lactamase (esbl)-producing strains of pseudomonas aeruginosa and bacteroides fragilis. cxa-201 was 2- t ... | 2011 | 21321149 |
| mutation in fucose synthesis gene of klebsiella pneumoniae affects capsule composition and virulence in mice. | the emerging pathogenicity of klebsiella pneumoniae (kp) is evident by the increasing number of clinical cases of liver abscess (la) due to kp infection. a unique property of kp is its thick mucoid capsule. the bacterial capsule has been found to contain fucose in kp strains causing la but not in those causing urinary tract infections. the products of the gmd and wcag genes are responsible for converting mannose to fucose in kp. a kp strain, kpl1, which is known to have a high death rate in infe ... | 2011 | 21321319 |
| bilateral klebsiella pneumoniae (k1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection. | the authors report a rare presentation of bilateral klebsiella pneumoniae endophthalmitis in an ambulatory patient without other known medical conditions. a 51-year-old chinese woman presented with severe bilateral reduction in vision, photophobia, pain, and eyelid swelling. hospital admission and evaluation revealed vitreous, blood, and urine cultures positive for k. pneumoniae (k1 serotype). additional work-up revealed endocarditis, multiple liver abscesses, brain abscesses, and left lobar pne ... | 2011 | 21323188 |
| comparison of in vitro activity of ertapenem with other carbapenems against extended-spectrum beta-lactamase-producing escherichia coli and kleibsella species isolated in a tertiary children's hospital. | the purpose of this study was to evaluate the susceptibility of extended-spectrum beta-lactamase (esbl)-producing enterobacteriaceae clinical isolates to ertapenem in a tertiary pediatric care center in turkey. | 2011 | 21323503 |
| assessing the effect of different ultrasonic frequencies on bacterial viability using flow cytometry. | aims: this research investigated the effect of sonication at frequencies of 20, 40 and 580 khz and approximately the same acoustic intensity on the viability and declumping of two micro-organisms (escherichia coli and klebsiella pneumonia). methods and results: two analytical methods were employed; viable plate counts (cfu ml(-1) ) and flow cytometry to identify and quantify both live/viable and dead bacteria in the bulk liquid. flow cytometry results for e. coli and kl. pneumonia indicated a ... | 2011 | 21324052 |
| sequence analysis of a group of low molecular-weight plasmids carrying multiple is903 elements flanking a kanamycin resistance aph gene in salmonella enterica serovars. | a group of low molecular-weight cole1-like plasmids carrying the aph sequence type aph(ii) from three different salmonella serovars were sequenced. these plasmids carry two or more copies of is903 elements, with up to 21bp sequence differences to one another, two of which flank the aph gene. this group of plasmids did not appear to carry any known mobilization genes and instead carry three open reading frames encoding hypothetical proteins of unknown function possibly organized in an operon. the ... | 2011 | 21324339 |
| time-kill synergy tests of tigecycline combined with imipenem, amikacin, and ciprofloxacin against clinical isolates of multidrug-resistant klebsiella pneumoniae and escherichia coli. | this study evaluated the activity of tigecycline combined with imipenem, amikacin, and ciprofloxacin against clinical isolates of multidrug-resistant klebsiella pneumoniae and escherichia coli co-producing extended-spectrum ß-lactamases and acquired ampc ß-lactamases. broth microdilution tests were performed for cefotaxime, ceftazidime, cefepime, imipenem, amikacin, ciprofloxacin, and tigecycline. time-kill synergy studies were tested for tigecycline plus imipenem, tigecycline plus amikacin, and ... | 2011 | 21325253 |
| new delhi metallo-ß-lactamase (ndm-1)-producing klebsiella pneumoniae: case report and laboratory detection strategies. | the spread of antimicrobial resistance among enterobacteriaceae is a significant clinical threat. we report the first case of an enterobacteriaceae strain harboring the ndm-1 metallo-ß-lactamase in a pediatric patient in the united states. we describe strategies for the detection of this novel resistance mechanism encountered in an isolate of klebsiella pneumoniae. | 2011 | 21325558 |
| isolation and characterisation of kp34--a novel fkmv-like bacteriophage for klebsiella pneumoniae. | bacteriophage kp34 is a novel virus belonging to the subfamily autographivirinae lytic for extended-spectrum ß-lactamase-producing klebsiella pneumoniae strains. its biological features, morphology, susceptibility to chemical and physical agents, burst size, host specificity and activity spectrum were determined. as a potential antibacterial agent used in therapy, kp34 molecular features including genome sequence and protein composition were examined. phylogenetic analyses and clustering of kp34 ... | 2011 | 21327407 |
| isolation of a selected microbial consortium capable of degrading methyl parathion and p-nitrophenol from a contaminated soil site. | a bacterial consortium with the ability to degrade methyl parathion and p-nitrophenol, using these compounds as the only carbon source, was obtained by selective enrichment in a medium with methyl parathion. samples were taken from moravia, medellin; an area that is highly contaminated, owing to the fact that it was used as a garbage dump from 1974 to 1982. acinetobacter sp, pseudomonas putida, bacillus sp, pseudomonas aeruginosa citrobacter freundii, stenotrophomonas sp, flavobacterium sp, prot ... | 2011 | 21328125 |
| extended-spectrum ß-lactamases of escherichia coli and klebsiella pneumoniae screened by the vitek 2 system. | the vitek 2 automated system (biomérieux) is one of the most widely used instruments in clinical microbiology laboratories for the identification and evaluation of the susceptibility profiles of bacteria including the detection of extended-spectrum ß-lactamases (esbls) produced by escherichia coli, klebsiella pneumoniae and klebsiella oxytoca. currently, the clinical and laboratory standards institute recommends the use of esbl confirmatory tests in addition to standard susceptibility testing. i ... | 2011 | 21330411 |
| acute klebsiella pneumoniae interface keratitis after deep anterior lamellar keratoplasty. | 2011 | 21331700 | |
| plasmid typing and genetic context of ampc β-lactamases in enterobacteriaceae lacking inducible chromosomal ampc genes: findings from a spanish hospital 1999-2007. | to gain insights into ampc transmission between bacterial strains. | 2012 | 21980067 |
| in vivo comparison of cxa-101 (fr264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms. | cxa-101 is a novel antipseudomonal cephalosporin with enhanced activity against gram-negative organisms displaying various resistance mechanisms. this study evaluates the efficacy of exposures approximating human percent free time above the mic (%ft > mic) of cxa-101 with or without tazobactam and piperacillin-tazobactam (tzp) against target gram-negative organisms, including those expressing extended-spectrum β-lactamases (esbls). sixteen clinical gram-negative isolates (6 pseudomonas aeruginos ... | 2012 | 22064538 |
| Emergence of carbapenem-resistant clinical Enterobacteriaceae isolates from a teaching hospital in Shanghai, China. | Carbapenems such as imipenem and meropenem are first-line agents for the treatment of serious nosocomial infections caused by multidrug-resistant clinical isolates of bacteria belonging to the family Enterobacteriaceae. However, resistance to carbapenems has increased dramatically among members of the family Enterobacteriaceae isolated from a teaching hospital in Shanghai, China. In the present study, we investigated the prevalence and molecular characteristics of carbapenem-resistant clinical i ... | 2012 | 21903823 |
| Simultaneous production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol by a recombinant strain of Klebsiella pneumoniae. | In this study, an aldehyde dehydrogenase (ALDH) was over-expressed in Klebsiella pneumoniae for simultaneous production of 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PDO). Various genes encoding ALDH were cloned and expressed in K. pneumoniae, and expression of Escherichia colialdH resulted in the highest 3-HP titer in anaerobic cultures in shake flasks. Anaerobic fed-batch culture of this recombinant strain was further performed in a 5-L reactor. The 3-HP concentration and yield re ... | 2012 | 22055092 |
| pharmacodynamics of β-lactamase inhibition by nxl104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases. | new broad-spectrum β-lactamases such as kpc enzymes and ctx-m-15 enzymes threaten to markedly reduce the utility of our armamentarium of β-lactam agents, even our most potent drugs, such as carbapenems. nxl104 is a broad-spectrum non-β-lactam β-lactamase inhibitor. in this evaluation, we examined organisms carrying defined β-lactamases and identified doses and schedules of nxl104 in combination with the new cephalosporin ceftaroline, which would maintain good bacterial cell kill and suppress res ... | 2012 | 22024819 |
| Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48. | Complete sequencing of plasmid pOXA-48a carrying the bla(OXA-48) gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla(OXA-48) gene had been integrated through the acquisition of the Tn1999 composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids. | 2012 | 22083465 |
| comparison of plasmid-mediated quinolone resistance and extended-spectrum β-lactamases in third-generation cephalosporin-resistant enterobacteriaceae from four irish hospitals. | in this study, the frequency of extended-spectrum β-lactamases (esbl) and plasmid-mediated quinolone resistance (pmqr) mechanisms were investigated in 206 clinical isolates of third-generation cephalosporin (3gc)-resistant enterobacteriaceae in four hospitals in the republic of ireland. bla(ctx-m-15) was the predominant esbl gene. of these 3gc resistant isolates, 54 % were also resistant to ciprofloxacin. investigation of the pmqr mechanisms revealed that the aac(6')ib-cr gene predominated in fl ... | 2012 | 21903826 |