Publications

nasal and paranasal sinus carcinoma: are we making progress? a series of 220 patients and a systematic review.	the authors reviewed treatment results in patients with nasal and paranasal sinus carcinoma from a large retrospective cohort and conducted a systematic literature review.	2001	11753979
[an epidemiological survey of thyroid disorders in an area with high iodine content in water supply].	to investigate the status of thyroid disorders among people aged 14 years and older residing in huanghua county, an iodine excess intake area in north china.	2001	11758239
reference intervals from birth to adulthood for serum thyroxine (t4), triiodothyronine (t3), free t3, free t4, thyroxine binding globulin (tbg) and thyrotropin (tsh).	disorders in thyroid function can impair normal development in children. therefore it was our aim to establish reference intervals for serum triiodothyronine (t3), free t3 (ft3), thyroxine (t4), free t4 (ft4), thyroxine binding globulin (tbg) and thyrotropin (tsh) which are applicable from birth to adulthood by using the non-isotopic automated chemiluminescence immunoassay system, immulite (dpc los angeles, usa). serum samples from 762 euthyroid newborns, children and adolescents (369 female, 39 ...	2001	11758614
diagnosis of congenital hypothyroidism from human anagen scalp hair by infrared microspectroscopy.	a highly efficient fourier transform infrared (ft-ir) microscopy was used to determine the biophysical structure of anagen scalp hair roots of neonates suffering from congenital hypothyroidism (ch) due to ectopic thyroid. the present results indicate that the lower composition near 1,053 cm(-1) (also assigned to the aromatic iodide stretching band) in the infrared (ir) spectra of the hair roots for ch patients was directly associated with the lower serum level of t4 and ft4, and the elevated tsh ...	2001	11758716
treatment of hypothyroidism.	thyroid disease affects up to 0.5 percent of the population of the united states. its prevalence is higher in women and the elderly. the management of hypothyroidism focuses on ensuring that patients receive appropriate thyroid hormone replacement therapy and monitoring their response. hormone replacement should be initiated in a low dosage, especially in the elderly and in patients prone to cardiac problems. the dosage should be increased gradually, and laboratory values should be monitored six ...	2001	11759078
postoperative altered plasma growth hormone levels--a predictor for postoperative complications? a case report.	we compared the onset of predictors for postoperative complications (lactate, total t2 (tt2), total t4 (tt4) and cortisone) retrospectively with the onset of altered growth hormone (gh) concentration in a patient who had had a lethal postoperative outcome and in 13 patients who were without postoperative complications for a period of 24 hours postoperatively. compared with the values of the patients without postoperative complications, gh values were elevated (68-fold) 1 h after surgery to 103 n ...	2001	11759187
morphophysiological status of rat thyroid gland after subchronic exposure to low frequency electromagnetic field.	the objective of this study was to examine the impact of low-frequency electromagnetic field on male rat thyroid gland of mill hill strain. animals were exposed to 50 hz frequency, of decaying intensity from 500 microt to 50 microt and 10 v/m field, beginning 24 hours after birth, 7 hours a day, 5 days a week during three months. results of histological and stereological analysis showed increased volume density of thyroid follicles, decreased thickness of the follicular epithelium, intrafollicul ...	2001	11759202
spontaneous thoracic spinal cord herniation--case report.	a 54-year-old female presented with spontaneous thoracic spinal cord herniation manifesting as chronic progressive motor weakness in both legs. spastic paraparesis (4/5) and pathological reflexes such as ankle clonus were noted. she also had mild bladder dysfunction but no bowel dysfunction. she had no sensory disturbance, including tactile and pinprick sense. magnetic resonance (mr) imaging revealed that the atrophic spinal cord was displaced into the ventral extradural space at the t4-5 interv ...	2001	11760388
[staging of rectal cancer by means of mri. experiences with the first twenty-five patients].	the danish surgical society recommends preoperative radiation for patients with t4 tumours of the rectum. however, the clinical examination with regard to fixation, especially for tumours in the upper part of the rectum, is encumbered by much uncertainty. mr imaging is a new modality in the staging procedure of the patient with rectal cancer. our experience with the first 25 patients is presented.	2001	11760541
thoracic splanchnic nerves: implications for splanchnic denervation.	splanchnic neurectomy is of value in the management of chronic abdominal pain. it is postulated that the inconsistent results of splanchnicectomies may be due to anatomical variations in the pattern of splanchnic nerves. the advent of minimally invasive and video-assisted surgery has rekindled interest in the frequency of variations of the splanchnic nerves. the aims of this study were to investigate the incidence, origin and pattern of the splanchnic nerves in order to establish a predictable p ...	2001	11760889
thyroid function in neonates with severe respiratory failure on extracorporeal membrane oxygenation.	the object was to study thyroid function in neonates with severe respiratory failure on extracorporeal membrane oxygenation (ecmo) and determine whether abnormal thyroid function correlates with prognosis. total and free thyroxine (t4, ft4), total and free triiodothyronine (t3, ft3), reverse triiodothyronine (rt3), thyroid-stimulating hormone, and thyroxine binding globulin were measured in 14 newborn infants with severe respiratory failure (age 1-30 days) from samples collected before anesthesi ...	2001	11761086
thyroidectomy induces neurofilament expression in adenohypophyses of rats.	we studied the effect of thyroidectomy on neurofilament expression in adenohypophyses of rats. the question of whether thyroxine (t4) administration can reduce this effect was also investigated. rats were divided into: 1. euthyroid controls, 2. thyroidectomized 20 d (tx 20 d), 3. thyroidectomized 20 d with replacement of t4 (tx 20 d + t4 20 d), 4. thyroidectomized 40 d (tx 40 d), 5. thyroidectomized 40 d with replacement of t4 20 d after surgery (tx 40 d + t4 20 d). adenohypophyses were studied ...	2001	11762706
cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats.	we evaluated the effects of hyperthyroidism on cardiac structural changes and postischemic myocardial function, and also studied how an angiotensin-converting enzyme (ace) inhibitor, cilazapril, can alter these changes. hyperthyroidism was induced by daily intraperitoneal injection of thyroxine (t4) (600 microg/kg) with or without cilazapril (10 mg/kg per day, orally), and control rats were given by vehicle. after 2 weeks of treatment, t4-treated rats showed increases in blood pressure and heart ...	2001	11762709
effects of racing and training on serum thyroid hormone concentrations in racing greyhounds.	to determine the effects of racing and training on serum thyroxine (t4), triiodothyronine (t3), and thyroid stimulating hormone (tsh) concentrations in greyhounds.	2001	11763190
[dynamics of spectral characteristics of theta- and alpha-range eeg during negative emotional reactions].	power characteristics of the eeg theta and alpha rhythms were studied in a human in neutral state and during a conditioned negative emotional reaction (fp1, fp2, f3, f4, c3, c4, p3, p4, o1, o2, f7, f8, t3, t4, t5, and t6 derivations). a significant increase in the relative spectral power in the narrow theta band of 7.4-8.1 hz in the frontocentral and temporal brain regions was observed during the development of the negative emotional reaction. the alpha-rhythm dynamics during the negative reacti ...	2001	11764515
thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dsfunction in apparently healthy subjects.	in order to establish its usefulness for the diagnosis and follow-up of thyroid autoimmune diseases, thyroid ultrasonography together with free t4 (ft4), free t3 (ft3), tsh, antibodies (tg ab) and thyroperoxidase antibodies (tpo ab) were performed and re-evaluated during a 3-yr follow-up in 482 apparently healthy subjects, living in a borderline iodine-sufficient urban area. thyroid dysfunction was found in 7 out of 12 (58.3%) subjects with circulating thyroid autoantibodies, who also had thyroi ...	2001	11765045
blood levels of atrial natriuretic peptide, endothelin, cortisol and acth in patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass.	previous studies demonstrated a biphasic time course with post-operative dissociation of blood levels of cortisol and acth in patients undergoing major surgery and critically ill patients. a possible role of endothelin and atrial natriuretic peptide (anp) in the dissociation of concentrations of cortisol and acth in critically ill patients has been suggested. in the present study, we investigated the perioperative course of blood levels of endothelin, anp, acth, and cortisol in 13 male patients ...	2001	11765047
mammary gland carcinoma-related increase of type i iodothyronine 5'-deiodinase activity in sprague-dawley rats.	type i, iodothyronine 5'-deiodinase (5'-di) catalyses deiodination of the prohormone thyroxine (t4) to the metabolically active 3,5,3'-triiodo-l-thyronine (t3). the present study was undertaken to investigate the activity of 5'-di in rat mammary gland tumours representing various combinations of histologically defined papillary, cribriform or comedo patterns of ductal carcinomas. female sprague-dawley rats were given two doses 50 mg x kg(-1) 1-methyl-1-nitrosourea (mnu) in abdominal parts on the ...	2001	11765219
effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of angora goats.	forty-eight angora goats (24 wethers and 24 doelings; 5 mo old; 16 +/- 0.5 kg initial bw) were used in an experiment with a 2 x 3 factorial treatment arrangement (n = 8) to evaluate effects of recombinant bovine somatotropin (bst) administration and thyroid hormone status (euthyroid, hypothyroid, and hyperthyroid) on hormone levels, adg, and mohair fiber growth. the bst was a slow-release zinc-based suspension, with sustained delivery (100 microg/[kg bw x d]) over a 14-d period. hyperthyroidism ...	2001	11768122
do different aminobisphosphonates have similar preventive effect on experimental thyroid hormone-induced osteopenia in rats?	we compared similar doses of three different aminobisphosphonates (bp): olpadronate (opd), pamidronate (apd), and alendronate (ale) on osteopenia induced by thyroxine (t4)-treatment in ovx and sham adult rats. female sprague dawley rats (259 +/- 8 g) were treated with vehicle (sham+vh and ovx+vh), 250 microg t4/kg/day (sham+t4 and ovx+t4), 0.3 mg opd/kg/day (sham+opd and ovx+opd), 0.2 mg ale/kg/day (sham+ale and ovx+ale), 1.5 mg apd/kg/day (sham+apd and ovx+apd), t4+opd (sham+t4+opd and ovx+t4+o ...	2001	11768202
responsiveness of the euroqol in breast cancer patients undergoing high dose chemotherapy.	to assess the responsiveness of the euroqol (eq-5d) by comparing it with the functional living index-cancer (flic) and a self-reported rating of health-related quality of life (hrql).	2001	11789549
histological changes of thyroid tissues in patients with liver cirrhosis.	alterations in thyroid hormone regulation and metabolism, such as low serum t3 and t4 with normal tsh, are frequently noted in liver cirrhosis, but few morphological studies have ever been done on thyroid tissue in liver cirrhosis. in this study we analyzed the histological changes of thyroid tissue in the patients with liver cirrhosis. specimens of thyroid gland obtained from autopsies in 16 cirrhotic patients were examined, and compared with those of two control groups. control group i consist ...	2001	11789557
clinical and pathological significance of vitamin d receptor gene polymorphism for prostate cancer which is associated with a higher mortality in japanese.	the purpose of this study was to investigate the taqi vitamin d receptor (vdr) polymorphism in both japanese prostate cancer patients and japanese noncancer controls in order to determine if an association exists between vdr genotype with clinical and pathological risk of prostate cancer patients. this study involved 115 patients with prostate cancer and 133 male age-matched noncancer controls genotyped for a previously described taqi restriction fragment length polymorphism (rflp) at codon 352 ...	2001	11789558
beware the malignant jellyfish.	small pleural effusions that cannot be assessed by thoracentesis prior to surgery may represent a diagnostic challenge in the patient with a resectable, non-small cell cancer of the lung. even if the effusion is drained preoperatively and analyzed, the cytology may be falsely negative. we have found that careful inspection of pleural effusions using a single small 2-cm incision and video-assisted thorascopy may reveal a gelatinous piece of clotlike material that resembles a jellyfish. this cohes ...	2001	11789806
[efficacy of computer tomography in locally disseminated non small cell lung cancer].	the results of computed tomography (ct) staging and surgical data have been compared to assess the former in diagnosing localized lung cancer. the study included 79 patients with locally advanced non-small cell lung cancer who had been treated by surgery. local invasion was adequately diagnosed by ct in 67 (84.8%) and primary tumor stage--51.9%; overdiagnosis--15.2% and underdiagnosis--32.9%. the ct and final diagnosis findings on lymphogenous dissemination matched in 64.6%; overdiagnosis--16.5% ...	2001	11785100
postnatal thyroid hormone replacement in very preterm infants.	transient hypothyroxinemia occurs frequently in very preterm infants and is caused by a combination of factors as immaturity of the hypothalamo-pituitary-thyroid system, loss of the maternal thyroxine (t4) contribution, immaturity of thyroid hormone metabolism, and neonatal illness. thyroid hormone is important in maturation of the brain, but also of heart and lungs. low neonatal t4 concentrations in plasma are related to worse clinical and neurodevelopmental outcome. despite these relationships ...	2001	11778912
impaired neurogenic and endothelium-dependent relaxant responses of corpus cavernosum smooth muscle from hyperthyroid rabbits.	we investigated the effect of hyperthyroidism on the responsiveness of the rabbit corpus cavernosum smooth muscle. in male albino rabbits, hyperthyroidism was established by oral feeding of l-thyroxine at increasing dosages (150-450 microg/kg) over an 8-week period. this treatment produced a stable hyperthyroid state as indicated by the increased serum t4 levels. the reactivity of corpus cavernosum tissue from hyperthyroid animals and euthyroid control animals was studied in organ chambers. hype ...	2001	11779026
[local staging of rectal carcinoma--comparison of endorectal ultrasonography and ct].	correct staging of adenocarcinoma of the rectum is mandatory before any therapeutic choice is made. important features are infiltration of the perirectal fatty tissue (t3 and t4) and the presence of locoregional lymphatic spread. computed tomography with rectal air insufflation (ct) was compared with transrectal ultrasonography (trus) in 212 patients. results of the preoperative examinations were compared with histological findings. the ct examination in evaluation of perirectal spread had an ac ...	2001	11787206
separation of 100-kilobase dna molecules in 10 seconds.	long double-stranded dna molecules were separated in microfabricated hexagonal arrays in less than 1 min, several orders of magnitude faster than by using conventional technology. dna samples were first concentrated at the entrance to the array in a thin band by entropic focusing. they were then separated by pulsed field electrophoresis. t4 (168.9 kbp) and lambda (48.5 kbp) dnas could be resolved into two clearly separated bands in approximately 10 s in these experiments. this corresponds to a m ...	2001	11791579
atomic force microscopy analysis of bacteriophages phikz and t4.	bacteriophage phikz was investigated by atomic force microscopy (afm) and transmission electron microscopy (tem). the well-known phage t4 was used as a reference sample. reproducible contact mode afm images of native and partially disintegrated particles of bacteriophage phikz in air were obtained. it was demonstrated that the heads of phikz and t4 phages were compressed differently and depended on adsorption onto highly ordered pyrolytic graphite and mica. we have established a procedure to par ...	2001	11794617
[effect of nitrates on active transport of iodine].	active iodine transport into the thyrocyte is catalyzed by the transmembrane transport protein na+/j- symport (nis) nitrates can expel iodine from the bond with this transport protein which was found not only in the thyrocyte membrane but also in the cell membrane of the gastric mucosa. the weight of the thyroid gland in mg was significantly greater even when calculated in relation to body weight in the nit group of rats who were given for 6 days nitrate by gastric tube (100 mg/kg/day) as compar ...	2001	11795183
newborn screening for congenital hypothyroidism, victoria, australia, 1977-1997. part 2: treatment, progress and outcome.	a controlled longitudinal prospective study is reported of physical and neuropsychological progress up to 12 years in 152 children with congenital hypothyroidism (ch), detected by newborn screening in the australian state of victoria and born between the onset of screening in mid-1977 and december 1988. linear growth of the ch children was normal. throughout they were slightly heavier and the median head circumference was slightly larger compared with reference data. those with thyroid aplasia r ...	2001	11795653
serum concentration of free t3, free t4 and tsh in healthy children.	it is rare that manufacturers report age-related ft3, ft4 and tsh normal ranges in healthy children.	2001	11795654
sea bream sparus aurata, an asymptomatic contagious fish host for nodavirus.	during an epidemiological survey of viral encephalopathy and retinopathy (ver) in diseased sea bass dicentrarchus labrax, a nodavirus isolate was recovered from net pen-reared sea bream sparus aurata harboured in the same farming premises. after the virus was isolated and identified by immunofluorescence on ssn-1 cells, sequence analysis with a pcr product from the t4 region of the capsid protein gene indicated that the virus shared 100% identity with a pathogenic virus strain isolated from sea ...	2001	11797913
[effect of thyroxine upon prevention of recurrence of graves' disease treated with antithyroid drugs].	to investigate the effect of thyroxine upon the prevention of recurrence of graves disease after treatment by antithyroid drugs.	2001	11798886
influence of type ii 5' deiodinase on tsh content in diabetic rats.	the influence of hypothalamic and pituitary type ii 5'deiodinase (5'd-ii) activities and t3 content on pituitary tsh content was investigated in streptozotocin (stz)-induced diabetic rats (d). the results show, first, that hypothalamic and pituitary 5'd-ii activities were lower in neonatal d rats versus control (c) rats, and the normal developmental pattern was altered. secondly, when d and c rats were thyroidectomized (tx) at 25 days of age (d+tx, c+tx), pituitary and hypothalamic 5'd-ii activi ...	2001	11800284
thymidylate synthase expression in stage ii and iii colon cancer: a retrospective review.	this study is a retrospective analysis of thymidylate synthase (ts) levels in patients with stage ii (t3 or t4) and iii colon cancer. two groups of patients were identified: one undergoing surgery alone (98 patients) and the second receiving adjuvant 5-fluorouracil chemotherapy (112 patients). ts analyses were carried out using the 106 monoclonal antibody and a published grading system dividing staining into high and low intensity. the distribution of patients with low versus high ts levels was ...	2001	11801762
radiotherapy, concomitant protracted-venous-infusion 5-fluorouracil, and surgery for ultrasound-staged t3 or t4 rectal cancer.	a prospective study was undertaken to evaluate the response and toxicity of neoadjuvant chemoradiotherapy for ultrasound-staged t3 or t4 rectal cancer.	2001	11805563
influence of severity of congenital hypothyroidism and adequacy of treatment on school achievement in young adolescents: a population-based cohort study.	to evaluate whether precociously treated subjects with congenital hypothyroidism (ch) are at risk of poor school performance in early adolescence, and to investigate which factors affect their school achievement.	2001	11808894
endocrinological study on growth retardation in rett syndrome.	to determine whether primary or secondary growth hormone (gh) deficiency has a causative role in linear growth retardation, a key feature in rett syndrome (rtt).	2001	11808895
immunological effects of long-term lead exposure among taiwanese workers.	exposure to lead has been shown to have a deleterious effect on the immune system. however, the findings of previous studies have been inconsistent. this may have been due to the increased susceptibility to intracellular pathogens and increased polyclonal and antigen-specific responses on exposure to lead. the objective of the current study was to evaluate the immune function of long-term workers with lead in a battery manufacturing plant. junior high school teachers were used as a control group ...	2001	11808916
effect of xenogenic repair enzymes on photoimmunology and photocarcinogenesis.	exposure to ultraviolet b (uvb) radiation leads to an increased generation of uvb-induced skin damage in humans. the most important uvb-induced side effects are uvb-induced immunosuppression and photocarcinogenesis and there is a large body of evidence that cyclobutane pyrimidine dimers (cpd) induced by uvb radiation play a pivotal role in both processes. the topical application of dna repair enzymes is a new innovative strategy to reduce the amount of cpds in human skin. two different methods h ...	2001	11809366
does age affect liver function and the hepatic acute phase response after major abdominal surgery?	the liver plays a key role in the inflammatory response during major surgery or infection. the influence of age on liver function and hepatic acute phase protein (app) synthesis should be serially studied in elderly patients undergoing major abdominal surgery.	2001	11810120
[change in vascular endothelial growth factor level in serum and urine of esophageal carcinoma patients].	the purpose of this study was to determine the serum and urine vascular endothelial growth factor (vegf) level in patients with esophageal carcinoma and to elucidate their significance of pre-operative vegf levels.	2001	11810770
the controversy of the treatment of critically ill patients with thyroid hormone.	there is currently a vast literature available on the changes in thyroid function tests that occur during non-thyroidal illness. the aetiology of these changes is, however, controversial, especially with respect to whether they play an adaptive role for the organism in order to cope with stress or whether they represent primary pathology of the pituitary-thyroid axis. this is particularly true for critically ill patients, in whom the most significant changes in thyroid function are observed. the ...	2001	11800518
[testosterone and shbg levels in blood serum in women with anorexia nervosa].	the reports concerning serum levels of sex hormone binding globulin (shbg) and testosterone in women with anorexia nervosa are controversial and few in number. the aim of the study was to assess the levels of fsh, lh, prl, unbound and bound testosterone, shbg, estradiol, free t4, tsh in women with anorexia nervosa. the tfi (testosterone free index) used to assess shbg ability to bind testosterone was also calculated. the studied group consisted of 29 women with anorexia nervosa: 15 women untreat ...	2001	11816297
elements in erythrocytes of population with different thyroid hormone status.	the contents of elements k, ca, fe, cu, zn, se, and rb in erythrocytes of 78 cases with different thyroid hormone status have been measured by proton-induced x-ray emission and neutron activation analysis. according to the status of thyroid hormones t3, t4, tsh, ft3, and ft4 detected by radioimmunoassay, the experiment subjects were divided into four groups (i.e., hyperthyroid, hypothyroid, critical [one of thyroid hormones was abnormal], and normal). elements contents and hormones levels of fou ...	2001	11817694
assessment of the ability of mononuclear blood cells to produce ifn-gamma in patients with laryngeal cancer.	the ability of mononuclear blood cells (pbmc), derived from patients with cancer of the larynx, to produce ifn-gamma in vitro was assessed in this paper. thirty patients (27 male, 3 female) were qualified to the study. their mean age was 65 (range: 41 to 78 years), tumour sizes found in the group were from t2 to t4, levels of pathologic malignancy g2 or g3. the percentage rates different blood cells phenotypes (cd3+, cd3+ hladr+, cd4+, cd8+, cd14+ hladr+, cd19+, cd56+) were evaluated by means of ...	2001	11820561
vascular endothelial growth factor and basic fibroblast growth factor in patients with squamous cell oesophageal cancer.	it is suggested that vascular endothelial growth factor (vegf) and basic fibroblast growth factor (bfgf) play an important role in tumor-induced angiogenesis. the purpose of this study was to estimate the correlation between vegf and bfgf levels and tumor pathological status according to ptnm classification in patients with squamous cell oesophageal cancer. a group of 25 healthy controls and 32 consecutive patients with oesophageal cancer were included in this study. serum vegf and bfgf levels w ...	2001	11820569
effects of thyroid hormones on inner mitochondrial membrane fluidity.	authors studied the effects of thyroid hormones and their diasteroisomers and 3,5-diiodothyronine (lt2) on the fluidity properties of inner mitochondrial membrane (imm) by specifical fluorescent probe for the internal zone of biological membranes, the 1,6-diphenyl-1,3,5-hexatriene (dph). the studied parameters are arrhenius and perrin plots. the dph shows a decreased fluorescence quenching in the presence of both t3 and t4. the maximum effect is observed with 2 nm lt2. lt2 is more effective than ...	2001	11822198
preliminary results on mood state, salivary testosterone:cortisol ratio and team performance in a professional soccer team.	mood, as measured by the profile of mood states questionnaire (poms), salivary cortisol (f) and testosterone (t) levels, and performance were examined in 17 male soccer players 4 times during a season. soccer players provided three saliva samples when getting up (resting values, 8 a.m.), before breakfast (11.30 a.m.), and between 4.00 p.m. and 6.00 p.m. the initial measures were performed 1 day following the start of season training (t1). they were then performed before and after a high-intensit ...	2001	11822478
[role of intersphincter resection among the surgical options for cancer of the distal rectum].	the surgical treatment of low rectal cancer has yet to be standardised. the aims of the study were to define the curative role of intersphincteric resection and to evaluate its indications and functional results through a retrospective clinical experience. from 1988 to 2000, out of 783 operations for primary rectal cancers (resectability rate 96%; restorative resections 83% and apr 10%) an intersphincteric resection was performed in 48 patients (31 male, 17 female, average age 62) for tumours lo ...	2001	11824051
the role of whole-body fdg-pet in preoperative assessment of tumor staging in oral cancers.	the aim of this study is to clarify the clinical utility of 2-deoxy-2-[18f]fluoro-d-glucose (fdg) positron emission tomography (pet) in determining the tnm classification in patients with oral cancer.	2001	11831398
development of an acanthamoeba-specific reverse dot-blot and the discovery of a new ribotype.	acanthamoeba is a genus of free-living amoebae, of which some species have been found to cause opportunistic infections in humans. the identification of these amoebae in natural and disease samples is based primarily upon morphological features. while these features are more than adequate for identification to the genus level, they are not useful for species-level identification. this not only leads to difficulty in the diagnosis of infections, but it makes an accurate assessment of the natural ...	2001	11831768
consequences of hypothyroidism on auditory system function in tshr mutant (hyt) mice.	the otological consequences of hypothyroidism and the outcome of thyroxin (t4) administration during the developmental period preceding the onset of hearing were examined in mice that express a point mutation in the gene encoding the thyrotropin receptor (tshr), the so-called hyt mouse. progeny of sires homozygous for the trait and heterozygous dams were injected with t4 or saline placebo from birth through the tenth postnatal day and auditory-evoked brainstem responses (abrs) to acoustic clicks ...	2001	11833606
prevention of auditory dysfunction in hypothyroid tshr mutant mice by thyroxin treatment during development.	based on previous work, it is clear that genetically hypothyroid tshr(hyt) mutant mice are congenitally deaf [o'malley et al. (1995) hear. res. 88: 181-189, sprinkle et al. 2001b, j. assoc. res. otolaryngol. doi: 10.1007/s101620010077]. however, the extent to which auditory development is dependent on the availability of thyroxin (t4) during specific developmental stages is unknown. the aim of this study was to determine the relative importance of prenatal and postnatal thyroxin on the ontogeny ...	2001	11833608
pectoralis major myocutaneous flap: analysis of complications in difficult patients.	the purpose of this study was to assess and discuss the effects of old age and systemic diseases on complications related to the use of a pectoralis major myocutaneous flap (pmmf) for reconstruction in head and neck surgery. eighty-four consecutive patients, operated on between january 1992 and december 1998, were included in the study. of these patients, 47 were in relatively good condition, while 37were old and frail or affected by systemic diseases. patients were monitored for complications d ...	2001	11829193
[classification of a 300,000-year-old dental crown of the upper loamy deposit of the bad canstatter travertine zone].	hominid dental remains were recovered in association with fossil bones and artifacts during systematic excavations in a loamy deposit located between the two travertine zones t4 and t5 at stuttgart-bad cannstatt, southwest germany. direct dating of a hominid tooth crown with thermoluminescence resulted in a date of 300 kya, which is in agreement with the holstein interglacial floral and faunal composition of this layer. the specimen is a lower left canine with hypoplastic morphology. this interp ...	2001	11838044
a study of quetiapine: efficacy and tolerability in psychotic adolescents.	to study the effectiveness, safety, and tolerability of quetiapine in adolescents with psychotic disorders.	2001	11838824
the n-terminal atpase site in the large terminase protein gp17 is critically required for dna packaging in bacteriophage t4.	double-stranded dna packaging in bacteriophages is apparently driven by the most powerful molecular motor ever measured. although it is widely accepted that a translocating atpase powers the dna packaging machine, the identity of the atpase that generates this driving force is unknown. evidence suggests that the large terminase protein gp17, which possesses two consensus atp binding motifs and an atpase activity, is a strong candidate for the translocating atpase in bacteriophage t4. this hypoth ...	2001	11846554
competition of tamoxifen with thyroxine for tbg binding: ligand binding assay and computational data.	tamoxifen, a nonesteroidal antiesterogen, is widely used in the treatment of breast cancer. recently, the effect of tamoxifen on thyroid function has caused considerable concern, yet the results of different studies are controversial and the precise mechanism of such influence is obscure. in view of the fact that some drugs such as furosemide, diclofenac and mefenamic acid, based on the structural similarities to thyroxine could compete for binding to thyroxine binding globulin (tbg) and appears ...	2001	11849618
thyroid dysfunction in children with down's syndrome.	thyroid function tests were carried out on 320 children with down's syndrome aged between 5 d and 10 y. thyroid function was normal in 230 patients (71.9%) and abnormal in 90 (28.1%). six patients (1.8%) had primary congenital hypothyroidism, one patient had acquired hypothyroidism and two had transient hyperthyrotropinaemia of the newborn. sixteen of the remaining 81 patients (25.3%) had compensated hypothyroidism with increased thyroid-stimulating hormone (tsh) levels (11-20 mu l(-1)). their t ...	2001	11853334
[features of hormonal status in men during long-term coma].	serum hormonal profiles were studied in 48 patients during long (6-56 days) coma. low t3 and t4 and an essential increase in the levels of hydrocortisone, prolactin, estradiol, and particularly progesterone (20-fold) in the presence of normal lh concentration and decreased level of fsh were observed on days 7-16. changes in the concentrations of sex hormones, similar to the "false pregnancy" condition, were the most pronounced in the patients who later died.	2001	11855066
a case of mediastinal angiomyolipoma.	angiomyolipoma is a common tumor of the kidney but has rarely been found in the mediastinum. we report a case of angiomyolipoma of the posterior mediastinum in a 62-year-old woman. she experienced exertional dyspnea and intermittent cough at admission. computed tomography indicated a tumor located at the left paravertebral and upper posterior mediastinum and mri imaging demonstrated a mass with low signal intensity in t1-weighted image at t4-5 level. thoracotomy was done for surgical removal of ...	2001	11855161
[association of atypical pulmonary tb, polyserositis, severe leukopenia and panniculitis. case report].	many reports have associated tuberculosis with haematological abnormalities. these reports suggest that severe pulmonary tuberculosis, if associated with reduced tissue cellular reaction, may cause blood discrasias. anemia was present in 32 percent of patients. leucopenia with neutropenia and lymphopenia was observed in 15 percent in patients with very severe clinical tuberculosis. active tuberculosis was associated with significant reductions in absolute numbers of total t, t4 and b lymphocytes ...	2001	11977490
thyroid cancer in children and adolescents--consequences in later life.	thyroid cancer is rare below the age of 16 years, with an annual incidence of 0.02-0.3 cases per 100,000. papillary and follicular thyroid cancer in childhood and adolescence is more advanced upon presentation than in adults, as evident from a higher frequency of extra-thyroidal spread. the recurrence rate is also higher. nevertheless, the prognosis for survival in children and adolescents is better than in adults; why this is so remains unclear. an approximately 30-fold increase in the incidenc ...	2001	11964025
chemoenzymatic synthesis of biotinylated nucleotide sugars as substrates for glycosyltransferases.	the enzymatic oxidation of uridine 5'-diphospho-alpha-d-galactose (udp-gal) and uridine 5'-diphospho-n-acetyl-alpha-d-galactosamine (udp-galnac) with galactose oxidase was combined with a chemical biotinylation step involving biotin-epsilon-amidocaproylhydrazide in a one-pot synthesis. the novel nucleotide sugar derivatives uridine 5'-diphospho-6-biotin-epsilon-amidocaproylhydrazino-alpha-d-galactose (udp-6-biotinyl-gal) and uridine 5'-diphospho-6-biotin-epsilon-amidocaproylhydrazino-n-acetyl-al ...	2001	11948877
[surgical treatment of neck lymph nodes in squamous cell carcinoma of the pyriform sinus].	the present study reports the results of 66 patients surgically treated for squamous cell carcinoma of the pyriform sinus between 1984 and 1996. twenty eight patients underwent mono!ateral neck dissection and bilateral neck dissection was performed in 38 cases, for a total of 104 radical neck dissections. of these, 73 (71%) were modified type iii dissections, 17 (16%) were classical, and 14 (13%) were modified type i and ii dissections. the primary lesion was strictly lateralized in 47 cases (71 ...	2001	11938706
a simple way to reduce heat stress in laying hens as judged by egg laying, body weight gain and biochemical parameters.	this study was designed to test the effects of feed withdrawal and darkening on the performance, triiodothyronine (t3), thyroxine (t4), thyroid-stimulating hormone (tsh), adrenocorticotropic hormone (acth), and some blood serum metabolite and mineral concentrations of laying hens reared at high ambient temperatures ranging from 25 to 35 degrees c. ninety, 16-week-old hens (ross brown) were divided into 3 groups, 30 hens each. the first group was used as control. hens in the second group (feed wi ...	2001	11942121
[effect of head-down bed rest on human eeg].	objective. to study the influences of short-term simulated weightlessness on human eeg. method. eeg of 12 male subjects (aged 18-22) was recorded, pre-hdbr (-6 degrees head down bed rest), mid-hdbr (3rd, 4th, 6th day) and post-hdbr (3rd day). then these eeg recordings were analyzed by power spectral analysis. result. during hdbr, peak frequency of eeg gradually slowed down (6th day, p<0.05). alpha-band activities were enhanced (alpha1: p<0.001. alpha2: 3rd and 6th day, p<0.05; 4th day, p<0.001) ...	2001	11892733
parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase iv study.	flavonoids, such as troxerutin, have been shown to be safe and effective agents for the treatment of chronic venous insufficiency. the fixed combination between troxerutin 150 mg and carbazochrome 1.5 mg (fleboside ampoules) was previously shown to have a good efficacy and safety profile in non-surgical patients with acute uncomplicated hemorrhoids. the purpose of this randomized, double-blind, placebo-controlled study was to investigate the efficacy and tolerability of the active combination in ...	2001	11922398
combined resection of invaded organs in patients with t4 gastric carcinoma.	to understand the efficacy of gastrectomy combined with the resection of other organs and to refine the indications for this type of surgery, the records of 156 patients with carcinoma of the stomach directly invading adjacent organs or structures (t4 gastric carcinoma) were analyzed retrospectively.	2001	11846064
correlation of topographic surface and volume data from three-dimensional electron microscopy.	three-dimensional(3d) reconstructions from tilt series in an electron microscope show in general an anisotropic resolution due to an instrumentally limited tilt angle. as a consequence, the information in the z direction is blurred, thus making it difficult to detect the boundary of the reconstructed structures. in contrast, high-resolution topography data from microscopic surface techniques provide exactly complementary information. the combination of topographic surface and volume data leads t ...	2001	11858704
forelimb locomotor generators and quadrupedal locomotion in the neonatal rat.	the spinal localization of the forelimb locomotor generators and their interactions with other spinal segments were investigated on in vitro brainstem-spinal cord preparations of new-born rats. superfusion of the cervicothoracic cord (c1-t4) with high k+/low mg2+ artificial cerebrospinal fluid (acsf) evoked rhythmic motor root activity that was limited to low cervical (c7, c8) and high thoracic (t1) spinal levels. this activity consisted of synchronous, homolateral bursts and a typical alternati ...	2001	11860467
hiv-1 protein tat reduces the glutamate-induced intracellular ca2+ increase in cultured cortical astrocytes.	the trans-activator protein tat of the human immunodeficiency virus type 1 (hiv-1) is regarded as an injurious molecule in the pathogenesis of hiv-1 associated encephalopathy (hive). we investigated the effects of tat on neuroligand-induced intracellular ca2+ increase in cultured astroglial cells. rat cortical astrocytes, human glioblastoma cells and glial restricted precursor cells, from a human embryonic teratocarcinoma cell line, were incubated with recombinant tat (100 ng/ml for 60 min) whic ...	2001	11860474
tumor angiogenesis as a prognostic factor in oral cavity carcinomas.	currently, lymph node metastasis and thickness of the tumor are the gold standard as a predictor of survival in patients with oral cavity squamous cell carcinoma (oscc). however, there is a significant correlation between microvessel density and the development of cervical metastases or recurrence. previous studies have demonstrated that head and neck cancers are able to induce an angiogenic response in experimental models. this factor shows a strong correlation with regional recurrence. in this ...	2001	11876537
safety of oral nicorandil before coronary artery bypass graft surgery.	nicorandil is a k(atp) channel opener used to treat angina. it is cardioprotective and a vasodilator. we conducted a prospective, randomized, double-blind, placebo-controlled study to assess oral nicorandil in patients undergoing coronary artery bypass grafting (cabg) with cardiopulmonary bypass (cpb). twenty-two patients received nicorandil (10 mg twice a day) and 23 patients received placebo. haemodynamic data were recorded before induction of anaesthesia (t0), 5 and 20 min after starting mech ...	2001	11878685
lateralizing and localizing values of ictal onset recorded on the scalp: evidence from simultaneous recordings with intracranial foramen ovale electrodes.	the value of scalp recordings to localize and lateralize seizure onset in temporal lobe epilepsy has been assessed by comparing simultaneous scalp and intracranial foramen ovale (fo) recordings during presurgical assessment. the sensitivity of scalp recordings for detecting mesial temporal ictal onset has been compared with a "gold standard" provided by simultaneous deep intracranial fo recordings from the mesial aspect of the temporal lobe. as fo electrodes are introduced via anatomic holes, th ...	2001	11879346
[aspects of thyroxin-bound globulin metabolism in preterm infants in certain pathological conditions].	a comprehensive evaluation has been undertaken of the functional status of the thyroid gland in premature infants presenting with sepsis. the content of the thyroid hormones t4, t3 was studied together with aspects of the thyroxin-bound globulin metabolism that proved to be of diagnostic value in the evaluation of abnormalities of metabolism in those premature infants presenting with sepsis.	2001	11881386
[epidemiology of acoustic neuromas in poland].	in 1996 the polish skull base surgery society was founded and assembled mainly otolaryngologists and neurosurgeons from several dozen clinics and hospital wards. its main aim was to encourage co-operation between those two specialties. for this reason among others a common project entitled: "epidemiology of acoustic neuromas in poland" was launched in 1997. information was collected from questionnaires in seven neurosurgery and in three laryngology centres in the years from 1997-1998. so far, no ...	2001	11868328
t2 tumors larger than five centimeters in diameter can be upgraded to t3 in non-small cell lung cancer.	among the tnm criteria, tumor size is a well-assessed factor in the prognosis of small tumors. a 3-cm cutoff point separates t1 from t2 tumors, whereas a size larger than 3 cm is not ascribed any prognostic value. instead, n2 is considered to be the worst prognostic factor for intrathoracic extended disease.	2001	11689795
chemoradiotherapy followed by surgery for thoracic esophageal cancer potentially or actually involving adjacent organs.	the objective of this study was to evaluate the therapeutic usefulness of chemoradiotherapy (crt) followed by surgery in patients with clinically t4 (ct4) esophageal cancer involving adjacent organs such as the trachea, main bronchi, and large vessels. thirty-seven patients with ct4 squamous cell carcinoma of the thoracic esophagus were enrolled in this study. the crt regimen comprised cisplatin (70 mg/m2) on day 1, 5-fluorouracil (700 mg/m2) on days 1-4 and external irradiation (200 cgy/day, to ...	2001	11869319
effects of zinc and vitamin a supplements on plasma levels of thyroid hormones, cholesterol, glucose and egg yolk cholesterol of laying hens.	the effects of zinc and vitamin a supplementation to the diet on some blood metabolites were evaluated in hisex brown laying hens from 56 weeks to 68 weeks of age. a total of 130 birds were divided into two main groups according to vitamin a treatment (0 and 3.44 mg retinyl acetate kg(-1) feed, respectively), each consisting of 65 hens. hens in both of the main groups were then divided into five zinc treatment groups (0, 25, 50, 100 and 200 mg zinc kg diet(-1) respectively) of 13 hens each. it w ...	2001	11883892
a unique group of self-splicing introns in bacteriophage t4.	we describe in this review, the salient splicing features of group i introns of bacteriophage t4 and propose, a hypothetical model to fit in the self-splicing of nrdb intron of t4 phage. occurrence of non-coding sequences in prokaryotic cells is a rare event while it is common in eukaryotic cells, especially the higher eukaryotes. therefore, t4 bacteriophage can serve as a good model system to study the evolutionary aspects of splicing of introns. three genes of t4 phage were found to have stret ...	2001	11886074
thyroid hormones in treatment of mood disorders.	although lithium carbonate is still the best validated and most preferred drug used for augmenting treatment of depression, t3 is perhaps the next best agent in this regard. equivocal evidence, clinical skepticism and lack of data with ssris have prevented its widespread use. on the basis of whatever evidence is available it appears to be safe and effective. t4 is useful for replacement purpose and in high doses may have a role in augmenting mood stabilizers. evidence for other therapeutic effec ...	2001	11887301
postpartum thyroid dysfunction and postpartum depression: are they two linked disorders?	postpartum has been considered as a period of risk for developing postpartum depression (pd) by some but not all authors, and this pd has been linked with postpartum thyroid dysfunction (pptd). the major aim of this study was to evaluate the relation between the presence of pptd and pd. design and	2001	11895224
chemotherapy with vinorelbine, cisplatin and continuous infusion of 5-fluorouracil in locally advanced breast cancer: a promising low-toxic regimen.	primary chemotherapy for locally advanced breast cancer, usually an anthracycline-containing regimen, improves local disease control allowing for an initially inoperable tumour to be resected. the feasibility and efficacy of a regimen containing vinorelbine (v), cisplatin (p) and 5-fluorouracil (5-fu) as continuous infusion (vifup regimen) for patients with locally advanced breast cancer were evaluated. twenty-six patients with a t4 breast cancer presentation (eight also had synchronous distant ...	2001	11911307
expression of choline oxidase gene (coda) enhances salt tolerance of the tobacco.	the coda gene for choline oxidase, which converts choline into betaine. this enzyme, cloned from a soil bacterium arthrobactor globiformis, has been transferred and expressed in tobacco by the agrobatcterium-method transformation through the binary plasmid pgah/coda. the pgah/coda carried with km(r) and hyg(r),and coding sequence for a transit peptide from rubisco small subunit gene (rbcs) was inserted between 35 s promoter and coda, so that the cod could be introduced into the chloroplast by th ...	2001	12040392
taxonomy of trichinella and the epidemiology of infection in the southeast asia and australian regions.	seven species belonging to the trichinella genus (five with encapsulated larvae and two with non-encapsulated larvae in host muscles) and three additional genotypes have been described to date: t. spiralis (genotype t1), a cosmopolitan species with a high infectivity to swine and rats; t. nativa (t2), etiological agent of sylvatic trichinellosis in arctic and subarctic areas of the holarctic region, and its related genotype (trichinella t6), detected in alaska, idaho, montana, pennsylvania, wyom ...	2001	12041576
cerebellar parameters in developing 15 day old rat pups treated with propylthiouracil in comparison with 5 and 24 day old.	to investigate and quantify structural parameters in the developing cerebellum during hypothyroidism in pre and postnatal stages in 15 day old rat pups in comparison with 5 and 24 day old.	2001	12002112
[hypothyroidism in hodgkin's disease patients]	purpose: study of thyroid function in hodgkin's disease patients in complete remission. patients and methods: we examined the thyroid function of 160 hodgkin's disease patients in complete remission for at least one year, and determined the values of supersensitive thyroid stimulating hormone (stsh), free t4 (ft4), free t3 (ft3) hormones. results: normal values were observed in 117 patients, subclinical change (only elevated stsh) in 28 patients, clinical hypothyroidism in 14 patients (also low ...	2001	12050689
low dose preoperative radiation in the treatment of carcinoma of the rectum.	recent advances in the treatment of cancer of the rectum show a steady improvement in survival. newer surgical techniques and expanding options for adjunctive therapy appear to have had a significant impact on improving both local control and distant disease. five-year survival of patients now ranges from 85-90% for stage i cancers and 50-55% for stage iii cancers. local recurrence of disease following curative surgical resections is dependent on the stage of the tumor and for some high-risk pat ...	2001	11975407
[thyroid function tests in viral chronic hepatitis].	one hundred and twenty five patients with virus b or c chronic active hepatitis and postnecrotic cirrhosis and different degrees of liver dysfunction were studied.	2001	12068536
[contribution of ultrasonography in the evaluation of subacute thyroiditis].	ultrasonography is a useful tool in diagnosing and monitoring thyroid pathology. the aim of this study was to evaluate the value of thyroid ultrasonography in the follow-up of subacute thyroiditis (sat). the study group included 48 subjects with clinical and biological diagnosis of subacute thyroiditis. all patients were evaluated by ultrasonography and followed-up for a mean period of 12 months. the evaluation protocol included biological data (tsh, t4, erythrocyte sedimentation rate--esr) and ...	2001	12092232
the emergence of erythromycin-resistant streptococcus pyogenes in seoul, korea.	high frequencies of erythromycin-resistant streptococci were reported in japan in the mid-1970s, and in finland in the late 1980s, related to an increase in the consumption of macrolide antibiotics in these countries. the frequency of erythromycin-resistant streptococcus pyogenes was reported to be only 2% in 1994, but we know that the susceptibility of the strains to antibiotics had not been tested routinely. we studied the resistance rates of streptococcus pyogenes to various antibiotics in se ...	2001	11455497
measurement of slow (micros-ms) time scale dynamics in protein side chains by (15)n relaxation dispersion nmr spectroscopy: application to asn and gln residues in a cavity mutant of t4 lysozyme.	a new nmr experiment is presented for the measurement of micros-ms time scale dynamics of asn and gln side chains in proteins. exchange contributions to the (15)n line widths of side chain residues are determined via a relaxation dispersion experiment in which the effective nitrogen transverse relaxation rate is measured as a function of the number of refocusing pulses in constant-time, variable spacing cpmg intervals. the evolution of magnetization from scalar couplings and dipole-dipole cross- ...	2001	11456632
ti location in the mfi framework of ti-silicalite-1: a neutron powder diffraction study.	the first direct evidence that ti atoms are not equally distributed in the 12 crystallographically independent t sites of the mfi framework is presented on the basis of neutron diffraction data collected at the hrpd instrument of the isis pulsed neutron source. we found strong evidence indicating that t6, t7, and t11 are the most populated sites and weak evidence that ti may be hosted in t10. ti occupancy can be excluded for sites t1, t2, t4, t5, t9, and t12. the occupancy of the remaining sites ...	2001	11456866
probing slow time scale dynamics at methyl-containing side chains in proteins by relaxation dispersion nmr measurements: application to methionine residues in a cavity mutant of t4 lysozyme.	a relaxation dispersion-based nmr experiment is presented for the measurement and quantitation of micros-ms dynamic processes at methyl side-chain positions in proteins. the experiment measures the exchange contribution to the 13c line widths of methyl groups using a constant-time cpmg scheme. the effects of cross-correlated spin relaxation between dipole-dipole and dipole-csa interactions as well as the effects of scalar coupling responsible for mixing of magnetization modes during the course o ...	2001	11457242
20 a cd4in16s35(14-) supertetrahedral t4 clusters as building units in decorated cristobalite frameworks.		2001	11457310
historical overview: searching for replication help in all of the rec places.	for several decades, research into the mechanisms of genetic recombination proceeded without a complete understanding of its cellular function or its place in dna metabolism. many lines of research recently have coalesced to reveal a thorough integration of most aspects of dna metabolism, including recombination. in bacteria, the primary function of homologous genetic recombination is the repair of stalled or collapsed replication forks. recombinational dna repair of replication forks is a surpr ...	2001	11459950