Publications

mandibular mechanics following osteotomy and appliance placement ii: bone strain on the body and condylar neck.	the purpose of this investigation was to determine if the mechanical environment of the mandible is changed by osteotomy and fixation, as assessed by the measurement of bone strain on the condylar neck and mandibular corpus.	2006	16546641
a randomized comparison of manual, mechanical and high-impulse chest compression in a porcine model of prolonged ventricular fibrillation.	elevated coronary perfusion pressure (cpp) during cpr is associated with return of spontaneous circulation (rosc). we compared cpp achieved with three methods of chest compression: manual (man), mechanical (mech) and high-impulse mechanical (hi) in a porcine model of prolonged ventricular fibrillation (vf). we hypothesized that hi (very rapid acceleration of the down-stroke) would produce greater cpps than man or mech, and that hi would also produce a higher rate of rosc.	2006	16563597
high prevalence of trypanosoma brucei gambiense group 1 in pigs from the fontem sleeping sickness focus in cameroon.	to understand the importance of domestic pigs in the epidemiology of human trypanosomiasis, pcr was used to identify trypanosome populations in 133 pigs from the fontem sleeping sickness focus of cameroon. the results from this study show that 73.7% (98/133) of pigs from the fontem area carry at least one trypanosome species. trypanosoma vivax, t. brucei s.l. and t. congolense forest were found in 34.6% (46/133), 40.0% (53/133) and 46.0% (61/133) of the pigs respectively. t. simiae and t. congol ...	2006	16567049
the postnatal development of neocortical neurons and glial cells in the göttingen minipig and the domestic pig brain.	the first mathematically unbiased estimates of neocortical cell numbers are presented from the developing pig brain, including a full description of tissue processing and optimal sampling for application of the stereological optical fractionator method in this species. the postnatal development of neocortical neurons and glial cells from the experimental göttingen minipig was compared with the postnatal development of neocortical neurons in the domestic pig. a significant postnatal development w ...	2006	16574805
histochemical assessment of early myocardial infarction using 2,3,5-triphenyltetrazolium chloride in blood-perfused porcine hearts.	although the chemical mechanism of the triphenyltetrazolium (ttc) reaction, for macroscopic detection of myocardial infarction, has been described previously, literature reports on correct tissue preparation and the use of this technique in intact large animals are lacking.	2006	16580232
facial injury of infant by domestic pig bite: neglect, ignorance, or house designs defect?		2006	16582824
microwave ablation for atrial fibrillation: dose-response curves in the cardioplegia-arrested and beating heart.	microwave ablation has been used to replace the traditional incisions used in the surgical treatment of atrial fibrillation. however, dose-response curves have not been established in surgically relevant models. the purpose of this study was to develop dose-response curves for the flex 10 (guidant, inc) microwave device in both the acute cardioplegia-arrested heart and on the beating heart.	2006	16368338
vascular closure stapler clip anastomosis decreases aortic cross-clamping time compared to interrupted nonabsorbable and running absorbable sutures in growing pigs.	the latest generation in titanium clip application systems, the vascular closure staples (vcs) system avoids intimal lesions and therefore minimizes the subsequent hyperplastic reaction, while at the same time enhancing distensibility and vascular growth. moreover, vcs clips allow the surgeon to perform vascular anastomosis easily and faster than conventional suture. this system may become the option of choice for vascular reconstruction in pediatric surgery where, as in the case of aortic and t ...	2006	16378146
the epidemiology of human trichinellosis in china during 2000-2003.	the endemic foci of trichinellosis continue to be mainly located in the southwestern, the central and northeastern china. the seroepidemiological surveys of t. spiralis infection in humans were carried out in six provinces or municipals (p/m) of china during 2000-2003, the overall seroprevalence was 3.57%. from 2000 to 2003, 17 outbreaks of human trichinellosis, with 828 cases and 11 deaths, were recorded in 8 p/a of china. all of 11 deaths occurred in the southwestern china (1 case in sichuan, ...	2006	16414006
vascular injury caused by mechanical thrombectomy in porcine arteries: akónya eliminator device versus arrow-trerotola percutaneous thrombolytic device.	to compare vascular injuries induced by a nonrotational thrombectomy device equipped with an adjustable basket (the akónya eliminator [ake] device) and the arrow-trerotola percutaneous thrombolytic device (ptd) in porcine external iliac arteries (eias).	2006	16415141
the elephant knee joint: morphological and biomechanical considerations.	elephant limbs display unique morphological features which are related mainly to supporting the enormous body weight of the animal. in elephants, the knee joint plays important roles in weight bearing and locomotion, but anatomical data are sparse and lacking in functional analyses. in addition, the knee joint is affected frequently by arthrosis. here we examined structures of the knee joint by means of standard anatomical techniques in eight african (loxodonta africana) and three asian elephant ...	2006	16420379
feasibility of real-time magnetic resonance-guided stent-graft placement in a swine model of descending aortic dissection.	to evaluate the pre-clinical feasibility of real-time magnetic resonance imaging (rtmri) to guide stent-graft placement for experimental aortic dissection (ad) and to alleviate disadvantages of ionising radiation and nephrotoxic contrast media. endovascular stent-graft placement for thoracic aortic disease is usually performed under x-ray guidance. the feasibility of rtmri-guided stent-graft placement is currently not known.	2006	16431874
paradoxical effects of aurintricarboxylic acid and rg-13577: acute thrombosis and in-stent stenosis in a passive-coated stent.	to investigate if a platelet inhibitor (aurintricarboxylic acid [ata]) and a heparin-mimicking antagonist (rg-13577) of basic fibroblast growth factor 2 (bfgf2) could be combined as a stable compound and attached to conventional bare metal stents to hinder thrombus formation and inflammatory reactions of stenting.	2006	16445329
chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs.	experimental studies have shown the beneficial effects of antioxidant supplementation on endothelial function in the presence of increased endogenous oxidative stress, whereas limited data are available under normal conditions. the present study tested the hypothesis that in normal pigs long-term antioxidants would have deleterious effects on the cardiovascular system. normal domestic pigs (v, n=6) were studied 12 weeks after dietary supplementation with vitamin e (100 iu/kg per day) and vitamin ...	2006	16446399
myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model.	to develop cardioprotection against peri-operative myocardial ischemia-reperfusion injury, we need animal models where the local metabolism and blood flow are studied concomitantly with the global circulatory consequences during regional coronary occlusion.	2006	16451157
effects of an inspiratory impedance threshold device on blood pressure and short term survival in spontaneously breathing hypovolemic pigs.	the inspiratory impedance threshold device (itd) has been shown to improve hemodynamic variables and survival outcomes during cardiopulmonary resuscitation in animals and humans. we hypothesized that use of an itd, with a resistance of -10 cm h2o, will improve hemodynamics and short-term survival rates during hypovolemic hypotension in spontaneously breathing pigs.	2006	16455176
the characteristics of postcountershock pulseless electrical activity may indicate the outcome of cpr.	when ventricular fibrillation is cardioverted to pulseless electrical activity (pea), pea has been regarded as a non-resuscitatable rhythm. yet, recent reports and our earlier observations suggested otherwise. we therefore investigated outcomes after postcountershock pea, and aimed to develop a scoring system for outcome classification at the onset of initial postcountershock pea.	2006	16459008
a novel model to test accuracy and reproducibility of mdct scan protocols for coronary calcium in vivo.	we compared the accuracy and reliability of prospectively triggered, retrospectively ecg gated, and non-gated ct image reconstruction for measurements of coronary artery calcification (cac) in vivo using a novel animal model.	2006	16374527
fully mr-guided hepatic artery catheterization for selective drug delivery: a feasibility study in pigs.	to demonstrate the feasibility of hepatic catheterization for selective delivery of therapeutic agents using a clinical mri scanner for real-time image guidance.	2006	16374883
people, pigs and parasites in new guinea: relational contexts and epidemiological possibilities.	within papua new guinea the relationship people have with their pigs varies between societies. these differences arise in the earliest phase of rearing piglets and result in domestic animals whose primary attachments are to other pigs, to places or to people. for papua new guineans, different pig management regimes fulfill ecological and social needs. in addition, however, the ways in which pigs are raised and managed, and the presence or absence of a local population of wild pigs, have conseque ...	2006	16337181
molecular cloning, expression and functional characterization of miniature swine cd86.	cd86 is one of the key molecules involved in the co-stimulation of t cells. the complete cdna encoding cd86 molecule of miniature swine was cloned and analyzed. a comparison of two cd86 amino acid sequences of miniature swine and domestic swine showed only three amino acid differences suggesting that it is unlikely to affect the major structural features of the miniature swine cd86 (mscd86). in the expression study, constitutive expression of cd86 mrna was detected in various tissues, and the ab ...	2006	16337491
the ppar-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.	rodent studies suggest that peroxisome proliferator-activated receptor-alpha (ppar-alpha) activation reduces myocardial ischemia-reperfusion (i/r) injury and infarct size; however, effects of ppar-alpha activation in large animal models of myocardial i/r are unknown. we determined whether chronic treatment with the ppar-alpha activator fenofibrate affects myocardial i/r injury in pigs. domestic farm pigs were assigned to treatment with fenofibrate 50 mg.kg(-1).day(-1) orally or no drug treatment ...	2006	16339839
a new method of selective, rapid cooling of the brain: an experimental study.	to determine whether retrograde perfusion of cooled blood into one internal jugular vein (ijv) in the pig can selectively reduce the brain temperature without affecting the core body temperature (cbt).	2006	16362468
healing pattern of bone defects covered by different membrane types--a histologic study in the porcine mandible.	few investigations on guided bone regeneration (gbr) focus on the behaviour of tissues adjacent to barrier membranes. this study was conducted to (1) evaluate the barrier function potential of different resorbable and nonresorbable membranes for gbr, (2) investigate their structural changes after different intervals, and (3) characterize tissue composition and reaction adjacent to the barrier by qualitative histologic evaluation. seven barriers for gbr were used per animal (made of dense or expa ...	2006	16362958
prp modulates expression of bone matrix proteins in vivo without long-term effects on bone formation.	this experimental study (domestic pig) examined the bone formation after filling defined defects of the frontal skull with autogenous bone or a deproteinized bovine bone matrix (dbbm) in combination with platelet-rich plasma (prp). six groups, both materials with and without prp in two different concentrations (4.1x and 6.5x referring to untreated whole blood) were evaluated at 2, 4, 12, and 26 weeks by means of immunohistochemical staining for different bone matrix proteins, microradiography, l ...	2006	16257592
enhanced external counterpulsation improves endothelium-dependent vasorelaxation in the carotid arteries of hypercholesterolemic pigs.	enhanced external counterpulsation (eecp) has been demonstrated to be an effective method for the treatment of atherosclerotic vascular disease. however, the exact mechanism underlying the beneficial effects of eecp is not completely clear. we hypothesized that eecp leads to improvement in endothelial function, contributing to its clinical benefits.	2006	16310261
antioxidant enzymes in ringed seal tissues: potential protection against dive-associated ischemia/reperfusion.	diving seals experience heart rate reduction and preferential distribution of the oxygenated blood flow to the heart and brain, widespread peripheral vasoconstriction, and selective ischemia in the most hypoxia-tolerant tissues. the first breath after the dive restores the oxygenated blood flow to all tissues and raises the potential for the production of reactive oxygen species (ros). we hypothesized that in order to counteract the damaging effects of ros and to tolerate repetitive cycles of is ...	2006	16269268
genetic characterization of type 2 porcine circoviruses detected in hungarian wild boars.	porcine circoviruses (pcv) are present in pigs worldwide; they are grouped into two types: pcv1 comprising non-pathogenic viruses and pcv2 responsible for several clinical manifestations. both types are frequently detected in domestic pigs, the prevalence and role of pcv in wild boars however, is not well studied. during the years 2002-2003 over 2000 organ samples of hungarian wild boars were collected, grouped and samples from 307 different animals were tested by polymerase chain reaction for t ...	2006	16328152
acute inhibition of the endogenous xanthine oxidase improves renal hemodynamics in hypercholesterolemic pigs.	hypercholesterolemia (hc), a major risk factor for onset and progression of renal disease, is associated with increased oxidative stress, potentially causing endothelial dysfunction. one of the sources of superoxide anion is xanthine oxidase (xo), but its contribution to renal endothelial function in hc remains unclear. we tested the hypothesis that xo modulates renal hemodynamics and endothelial function in hc pigs. four groups (n = 23) of female domestic pigs were studied 12 wk after either no ...	2006	16284087
retroposed elements as archives for the evolutionary history of placental mammals.	reconstruction of the placental mammalian (eutherian) evolutionary tree has undergone diverse revisions, and numerous aspects remain hotly debated. initial hierarchical divisions based on morphology contained many misgroupings due to features that evolved independently by similar selection processes. molecular analyses corrected many of these misgroupings and the superordinal hierarchy of placental mammals was recently assembled into four clades. however, long or rapid evolutionary periods, as w ...	2006	16515367
ten years evidence-based high-tech acupuncture--a short review of peripherally measured effects.	since 1997, the research unit of biomedical engineering in anesthesia and intensive care medicine of graz medical university has been dealing with the demystification of acupuncture and examining, using non-invasive methods, how different stimulation modalities (manual needle acupuncture, laserneedle acupuncture and electro acupuncture) affect peripheral and central functions. laser is also an important instrument for acupuncture. one only needs to mention the treatment of children or of patient ...	2007	18955279
anomalous ion diffusion within skeletal muscle transverse tubule networks.	skeletal muscle fibres contain transverse tubular (t-tubule) networks that allow electrical signals to rapidly propagate into the fibre. these electrical signals are generated by the transport of ions across the t-tubule membranes and this can result in significant changes in ion concentrations within the t-tubules during muscle excitation. during periods of repeated high-frequency activation of skeletal muscle the t-tubule k+ concentration is believed to increase significantly and diffusive k+ ...	2007	17509153
beating heart aortic valve replacement using real-time mri guidance.	: the principal limitations of percutaneous techniques to replace the aortic valve are detailed visualization and durable prostheses. we report the feasibility of using real-time magnetic resonance imaging (mri) to provide precise anatomic detail and visual feedback to implant a proven bioprosthesis.	2007	22436922
rational intraabdominal pressure monitoring: how to do it?	intraabdominal hypertension (iah) is increasingly appreciated by intensivists as an important cause of organ dysfunction, even at pressure levels which were previously thought to be harmless. therefore, the goal of this review is to describe the different methods commonly used in clinical practice for intraabdominal pressure (iap) measurement, the advised methodology for each measurement method, and finally to give a rational approach for iap monitoring in daily clinical practice.	2007	24881697
dental and skeletal characterization of the br-1 minipig.	this study was designed to characterize the development of oral structures in the br-1 minipig and to compare these data with literature reports on domestic swine and other minipig lineages. twelve male minipigs were anesthetized and given physical and radiographic examinations. the presence and chronology of tooth eruption from 3 to 15 months of age were assessed, and the radiographic results were interpreted by two certified researchers, who obtained a high index of agreement (kappa>0.81). the ...	2007	16376127
increased spatial vasa vasorum density in the proximal lad in hypercholesterolemia--implications for vulnerable plaque-development.	vasa vasorum (vv) neovascularization is associated with advanced and ruptured atherosclerotic lesions that occur predominantly within the proximal third of the lad. to investigate further the possible role of vv spatial distribution in determining this predominantly proximal location of complex lesions we analyzed the changes in vv spatial densities along the lad in early atherosclerosis.	2007	16919638
marker vaccine strategies and candidate csfv marker vaccines.	classical swine fever (csf) is an economically important highly contagious disease of swine worldwide. classical swine fever virus (csfv) is its etiological agent, and the only natural hosts are domestic pigs and wild boars. although field csfv strains vary in the virulence, they all result in serious losses in pig industry. highly virulent field strains generally cause acute disease and high mortality; moderately virulent field strains raise subacute or chronic infections; postnatal infection b ...	2007	16934915
prevalence of streptococcus suis genotypes in wild boars of northwestern germany.	invasive serotype 2 (cps2+) strains of streptococcus suis cause meningitis in pigs and humans. four case reports of s. suis meningitis in hunters suggest transmission of s. suis through the butchering of wild boars. therefore, the objective of this study was to investigate the prevalence of potentially human-pathogenic s. suis strains in wild boars. s. suis was isolated from 92% of all tested tonsils (n=200) from wild boars. a total of 244 s. suis isolates were genotyped using pcr assays for the ...	2007	17085699
molecular identification of trichuris vulpis and trichuris suis isolated from different hosts.	trichuris suis was isolated from the cecum of two different hosts (sus scrofa domestica -- swine and sus scrofa scrofa -- wild boar) and trichuris vulpis from dogs in sevilla, spain. genomic dna was isolated and internal transcribed spacers (its)1-5.8s-its2 segment from the ribosomal dna (rdna) was amplified and sequenced using polymerase chain reaction techniques. the sequence of t. suis from both hosts was 1,396 bp in length while that of t. vulpis was 1,044 bp. its1 of both populations isolat ...	2007	17004099
genetic involvement in skin wound healing and scarring in domestic pigs: assessment of molecular expression patterns in (yorkshire x red duroc) x yorkshire backcross animals.	yorkshire, red duroc, and f1 (first-generation cross) pigs heal with normal, fibroproliferative/hypercontractile, and intermediate levels of scarring, respectively. the purpose of this study was to evaluate the healing phenotype of yorkshire x f1 backcross animals, to address the molecular basis for genetic transmission of the red duroc scarring phenotype. macroscopically and histologically, full-thickness wounds on backcross animals followed the yorkshire phenotype, with one exception; the back ...	2007	16858423
compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs.	subretinal implants aim to replace photoreceptor function in patients suffering from degenerative retinal disease like retinitis pigmentosa by topically applying electrical stimuli in the subretinal space. this study-as a last step before upcoming human trials-explored a newly developed surgical technique for permanent implantation of complex subretinal implants with extra-ocular parts.	2007	16645861
identify the injury implements by sem/edx and icp-aes.	the forensic investigator is frequently confronted with the discrimination and deduction of injury implements, which is one of the most important physical testimonies in courts. the usual method used in actual cases is from points of morphology. in the forensic discrimination of injury implements, such as metal implements, the analysis and comparison of elements are expected to provide excellent results, and simultaneous multi-elemental analysis is required to analyze various kinds of elements. ...	2007	16621384
the epidemiology of animal trichinellosis in china.	the epidemiology of animal trichinellosis in china based mainly upon original chinese literature published between 1937 and 2004 is reviewed. the seroprevalence of trichinella infection in herbivores was 0.7% (2/300) in cattle and 0.8% (4/500) in sheep. the prevalence of trichinellosis in naturally infected cattle was 1.2% (2/163). trichinella larvae were detected in 1.4% (3/215) of sheep and in 2.1% (1/47) of beef cattle sold at markets. canine trichinellosis was recorded in 13 provinces, auton ...	2007	16162414
a one-step, gel-based rt-pcr assay with comparable performance to real-time rt-pcr for detection of classical swine fever virus.	classical swine fever, a notifiable disease to the office international des epizooties (oie), is a highly contagious viral disease affecting both domestic pigs and wild boars. rapid, sensitive, and specific detection of the causing agent classical swine fever virus (csfv) is therefore essential for diagnosis and control of the disease. most protocols for gel-based pcr consist of two steps, reverse transcription followed by pcr. such a protocol is time consuming, laborious and more prone to conta ...	2007	17123637
evaluation of baculovirus-derived recombinant 53-kda protein of trichinella spiralis for detection of trichinella-specific antibodies in domestic pigs by elisa.	the complete gene encoding the 53-kda protein derived from trichinella spiralis was cloned and expressed using a baculovirus-based system. characterization of a purified fusion protein consisting of the 53-kda protein and the glutathione s-transferase protein showed unspecific reactivity with swine pre-immune serum in both enzyme-linked immunosorbent assay (elisa) and western blot analysis. subsequently, a purified c-terminal 6xhis-tagged 53-kda protein was used in an elisa. the evaluation of th ...	2007	17016726
molecular epidemiology of trichinella spp. in three baltic countries: lithuania, latvia, and estonia.	meat of domestic pigs and wild boars has been the significant source of emerged human trichinellosis in lithuania, latvia, and estonia over the past two decades. however, there is very little known on the occurrence of trichinella spp. in main wildlife reservoirs and its transmission in domestic and sylvatic cycles in these countries. the present study demonstrated considerably higher endemicity of trichinella spp. in main sylvatic reservoirs (28.9-42% in foxes (vulpes vulpes) and raccoon dogs ( ...	2007	17013647
nutrient losses from manure and fertilizer applications as impacted by time to first runoff event.	nutrient losses to surface waters following fertilization contribute to eutrophication. this study was conducted to compare the impacts of fertilization with inorganic fertilizer, swine (sus scrofa domesticus) manure or poultry (gallus domesticus) litter on runoff water quality, and how the duration between application and the first runoff event affects resulting water quality. fertilizers were applied at 35 kg p ha-1, and the duration between application and the first runoff event varied betwee ...	2007	17029684
laparoscopic ice slurry coolant for renal hypothermia.	we assessed the safety and efficacy of microparticulate ice slurry for laparoscopic hypothermia during renal ischemia in a single kidney porcine model.	2007	17162095
chinese white rongchang pig does not have the dominant white allele of kit but has the dominant black allele of mc1r.	the mast/stem cell growth factor receptor (kit) and melanocortin receptor 1 (mc1r) mutations are responsible for coat color phenotypes in domestic pigs. rongchang is a chinese indigenous pig breed with a white coat color phenotype. to investigate the genetic variability of the kit and mc1r genes and their possible association with the coat color phenotype in this breed, a gene duplication and splice mutation of kit were diagnosed in a sample of 93 unrelated rongchang animals. the results show th ...	2007	17150979
porcine circovirus type 2 antibody detection in backyard pigs from mexico city.	pcv2 antibodies have been found in pigs from all continents. however, this finding has been mainly studied in domestic swine reared under intensive production conditions. mexico city, with a human population over 19 million in 2005, has both urban and rural areas. the pig production in its rural area is based on small family backyard farms. taking into account this rather unique form of rearing pigs, the objective of this study was to determine the seroprevalence in backyard pigs from the rural ...	2007	17157886
subretinal posterior pole injury induces selective proliferation of rpe cells in the periphery in in vivo studies in pigs.	to study topographical differences in porcine retinal pigment epithelial (rpe) cell proliferation (1) in vivo, after experimental central surgical subretinal injury, and (2) in vitro.	2007	17197554
patent foramen ovale: standards for a preclinical model of prevalence, structure, and histopathologic comparability to human hearts.	this study evaluated and standardized a patent foramen ovale (pfo) preclinical model in gross anatomic and histopathologic features.	2007	17173313
genetic characterisation of african swine fever viruses from outbreaks in southern africa (1973-1999).	african swine fever (asf) is a highly lethal and economically significant disease of domestic pigs in the southern african sub-region, where outbreaks regularly occur. there is anecdotal evidence suggesting that trans-boundary movement of infected animals may have played a role in precipitating widespread outbreaks in the past, however, since the 1970s outbreaks have generally been more localised, particularly in those countries where control of animal movement is strictly regulated. the origin ...	2007	17174485
analysis of the physical properties of costal cartilage in a porcine model.	to determine the impact of interventions on the degree of warping of costal cartilage.	2007	17224486
low tube voltage improves computed tomography imaging of delayed myocardial contrast enhancement in an experimental acute myocardial infarction model.	we sought to evaluate the influence of tube voltage on the visualization of acute myocardial infarction (mi) in cardiac multislice spiral computed tomography (msct).	2007	17220730
acetylcholine injection into the amygdala elicits vocalization in domestic pigs (sus scrofa).	in a pilot study we have injected the amygdala of five female pigs (age 8 weeks) with acetylcholine (ach, 5.5mum/20mul) and recorded short latency utterances. the evoked vocalizations displayed the characteristics of natural screams in sonagram appearance and hearing impression. quantitative analyses, too, revealed the similarity of the ach-evoked vocalizations with natural screaming. the results demonstrate for the first time that aversive vocalizations can be triggered by cholinergic amygdala ...	2007	17215052
progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients.	work in rodents has shown that cultured retinal progenitor cells (rpcs) integrate into the degenerating retina, thus suggesting a potential strategy for treatment of similar degenerative conditions in humans. to demonstrate the relevance of the rodent work to large animals, we derived progenitor cells from the neural retina of the domestic pig and transplanted them to the laser-injured retina of allorecipients. prior to grafting, immunocytochemical analysis showed that cultured porcine rpcs wide ...	2007	17218397
enteric caliciviruses in domestic pigs in hungary.	caliciviruses closely related to human norovirus and sapovirus were recently detected in domestic pigs, causing discussions about the animal reservoir and the potential for zoonotic transmission to humans. to detect porcine caliciviruses, 17 fecal samples collected on two swine farms in southwestern hungary were tested by reverse transcription-polymerase chain reaction. three (17.6%) samples were positive for caliciviruses. this study confirms the presence of caliciviruses, both porcine sapoviru ...	2007	17180626
a history of normal plates, tables and stages in vertebrate embryology.	developmental biology is today unimaginable without the normal stages that define standard divisions of development. this history of normal stages, and the related normal plates and normal tables, shows how these standards have shaped and been shaped by disciplinary change in vertebrate embryology. the article highlights the normal plates of the development of the vertebrates edited by the german anatomist franz keibel (16 volumes, 1897-1938). these were a major response to problems in the relat ...	2007	17183461
an advanced sheep (ovis aries, 2n = 54) cytogenetic map and assignment of 88 new autosomal loci by fluorescence in situ hybridization and r-banding.	presented herein is an updated sheep cytogenetic map that contains 452 loci (291 type i and 161 type ii) assigned to specific chromosome bands or regions on standard r-banded ideograms. this map, which significantly extends our knowledge of the physical organization of the ovine genome, includes new assignments for 88 autosomal loci, including 74 type i loci (known genes) and 14 type ii loci (ssrs/microsatellite marker/stss), by fish-mapping and r-banding. comparison of the ovine map to the catt ...	2007	17433010
[laparoscopic diagnostics of the acute bowel ischemia--first experimental experience].	aim of the study was to prove possibilities of laparoscopic diagnostics of an acute bowel ischemia when using fluorescein dye and the ultra-violet (uv) light.	2007	17436677
effects of an impedance threshold device on hemodynamics and restoration of spontaneous circulation in prolonged porcine ventricular fibrillation.	an impedance threshold device (itd) has been designed to enhance circulation during cpr by creating a negative intrathoracic pressure during the relaxation phase of chest compression.	2007	17454804
pandemic influenza planning: shouldn't swine and poultry workers be included?	recent research has demonstrated that swine and poultry professionals, especially those who work in large confinement facilities, are at markedly increased risk of zoonotic influenza virus infections. in serving as a bridging population for influenza virus spread between animals and man, these workers may introduce zoonotic influenza virus into their homes and communities as well as expose domestic swine and poultry to human influenza viruses. prolonged and intense occupational exposures of huma ...	2007	17459539
rational intraabdominal pressure monitoring: how to do it?	intraabdominal hypertension (iah) is increasingly appreciated by intensivists as an important cause of organ dysfunction, even at pressure levels which were previously thought to be harmless. therefore, the goal of this review is to describe the different methods commonly used in clinical practice for intraabdominal pressure (iap) measurement, the advised methodology for each measurement method, and finally to give a rational approach for iap monitoring in daily clinical practice.	2007	17469698
use of laryngeal mask airway compared to endotracheal tube with positive-pressure ventilation in anesthetized swine.	to compare the ease of placement and ventilatory parameters of a laryngeal mask airway (lma) with an endotracheal tube (ett) in anesthetized swine during positive-pressure ventilation (ppv).	2007	17490468
fibroepithelial hamartoma in a domestic pig.	this case report is the first description of a fibroepithelial hamartoma in a pig. the dysplasia, which covered half of the face of the newborn piglet, did not increase in relative size until the animal was euthanatized at 6 months of age. histologic examination revealed a moderate orthokeratotic hyperkeratosis with variable degrees of epithelial proliferation. the main body of the dysplasia consisted of collagenous fibers. in addition, some proliferating small blood vessels as well as focally g ...	2007	17491090
proof-of-concept study of the aer-o-scope omnidirectional colonoscopic viewing system in ex vivo and in vivo porcine models.	the limited angle of view of standard colonoscopes means that lesions can be missed. a multidirectional viewing system (omnivision) has been developed recently and has been incorporated into the aer-o-scope (gi view ltd., ramat gan, israel), a disposable, self-propelling, and self-navigating colonoscope. the objectives of this study were to qualitatively assess the sensitivity of this viewing system in an ex vivo porcine polyp induction model, and to demonstrate its feasibility and safety in liv ...	2007	17516347
skin changes following minor trauma.	bruises are currently evaluated by visual inspection, and little is known about the first phase after injury. the temporal development of fresh injuries must be accurately described to be able to age bruises in a reliable manner. color changes in a bruise caused by hemoglobin breakdown products will depend on the severity of the trauma, and thus on the local immune response in the skin. it is therefore important to relate the nature of the impact to the temporal tissue responses.	2007	17523178
transgastric cholecystectomy: transgastric accessibility to the gallbladder improved with the semf method and a novel multibending therapeutic endoscope.	transgastric cholecystectomy is thought to technically and anatomically challenge a single entry flexible endoscopic approach.	2007	17531637
an animal training model for endoscopic treatment of zenker's diverticulum.	zenker's diverticulum (zd) is an uncommon disease, which is typically treated surgically. the alternative to surgery is a diverticulotomy, performed endoscopically. given the rarity of this condition, it is not possible to obtain training. there has been no animal model identified that resembles the disease in human beings.	2007	17531640
histological and histomorphometric investigation of the condylar cartilage of juvenile pigs after anterior mandibular displacement.	the condylar cartilage of the mandible is considered a secondary growth center and represents a joint cartilage different from other cartilage structures regarding its histological structure, its histochemical and immunohistochemical properties and its growth pattern. this study aimed to histologically and histomorphometrically investigate the condylar cartilage after anterior mandibular displacement similar to functional orthopedic treatment. a total of 12 pigs (sus scrofa domesticus) aged 10 w ...	2007	17534034
characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs.	the pig, sus scrofa domestica includes both the miniature and commercial domestic breed. these animals have influenced the human life and economies and have been studied throughout history. although the miniature breeds are more recent and have increasingly been used in a variety of biomedical studies, their cell lines have rarely been established. therefore, we sought to establish primary and immortal cell lines derived from both the miniature and domestic pig to better enable insight into poss ...	2007	17543094
treating ischemic left ventricular dysfunction with hypertonic saline administered after coronary occlusion in pigs.	the effects of hypertonic saline on ventricular function are controversial, whether it is increasing contractility or preload. there are no data, however, on the influence of hypertonic saline in a stunned myocardium.	2007	17544894
the quality of chest compressions during cardiopulmonary resuscitation overrides importance of timing of defibrillation.	we address the quality of chest compressions and the impact on initial defibrillation or initial chest compressions after sudden death.	2007	17550931
cytochrome p450arom, androgen and estrogen receptors in pig sperm.	androgens and estrogens are crucial for mammalian sperm differentiation but their role in biology of mature male gamete is not still defined. the expression of proteins involved in the biosynthesis and action of these steroid hormones has been demonstrated in human spermatozoa, but very few data have been reported in mature sperm from non human species. the purpose of the current study was to investigate the expression of aromatase (p450arom), estrogen (eralpha/erbeta) and androgen (ar) receptor ...	2007	17553131
[sex-linked erythrocyte antigens of the domestic pig].	it has been demonstrated that the domestic pig has a blood group systems whose haplotypes (complex alleles) are formed by at least three closely linked loci that are located, like the mic2 locus of human blood group systems, in the homologous region of sex chromosomes.	2007	17555129
effectiveness and renal tolerance of multidetector helical ct with gadobutrol: results of a comparative porcine study.	to prospectively evaluate the safety and effectiveness of high doses of 1 mol/l gadobutrol as a contrast agent for computed tomography (ct).	2007	17562809
the no donor sin-1 improves intestinal-arterial p(co(2)) gap in experimental endotoxemia: an animal study.	dysfunction of the microcirculation is a prominent feature of sepsis and endotoxemia. recently, it has been shown that microcirculatory alterations are completely reversed by local or systemic application of vasodilators in severely septic patients. therefore, we investigated the influence of vasodilator therapy on microcirculatory dysfunction of the ileum during endotoxic shock in a prospective, controlled animal study.	2007	17567269
alternative splicing and expression profile analysis of expressed sequence tags in domestic pig.	domestic pig (sus scrofa domestica) is one of the most important mammals to humans. alternative splicing is a cellular mechanism in eukaryotes that greatly increases the diversity of gene products. expression sequence tags (ests) have been widely used for gene discovery, expression profile analysis, and alternative splicing detection. in this study, a total of 712,905 ests extracted from 101 different non-normalized est libraries of the domestic pig were analyzed. these est libraries cover the n ...	2007	17572361
first isolation of haemophilus parasuis and other nad-dependent pasteurellaceae of swine from european wild boars.	haemophilus parasuis is a colonizer of the upper respiratory tract of pigs and the etiological agent of glässer's disease, which is characterized by a fibrinous polyserositis, meningitis and arthritis. glässer's disease has never been reported in wild boar (sus scrofa), although antibodies against h. parasuis have been detected. the goal of this study was to confirm the presence of this bacterium in wild boar by bacterial isolation and to compare the strains to h. parasuis from domesticated pigs ...	2007	17574352
microwave ablation with multiple simultaneously powered small-gauge triaxial antennas: results from an in vivo swine liver model.	to prospectively investigate the ability of a single generator to power multiple small-diameter antennas and create large zones of ablation in an in vivo swine liver model.	2007	17581900
identification of genotype 4 hepatitis e virus strains from a patient with acute hepatitis e and farm pigs in bali, indonesia.	a previous study revealed that antibodies to hepatitis e virus (hev) (anti-hev) are highly prevalent among healthy individuals and farm pigs in bali, indonesia, and suggested that hev infection may occur via zoonosis among balinese people. however, there were no reports of acute hepatitis e in bali. to elucidate whether balinese hev strains recovered from infected humans and pigs have significant sequence similarity, serum samples obtained from 57 patients (age, mean +/- standard deviation, 31.1 ...	2007	17596841
positive effect of darbepoetin on peri-infarction remodeling in a porcine model of myocardial ischemia-reperfusion.	erythropoietin (epo) has anti-apoptotic and pro-angiogenic effects in rodent models of myocardial infarction (mi). we tested the hypothesis that a long-acting epo derivative (darbepoetin) has a beneficial effect on infarct size and peri-infarct remodeling in a clinically relevant large animal model of ischemia-reperfusion. a human acute mi scenario was simulated in 16 domestic pigs by inflating an angioplasty balloon in the proximal left circumflex (lcx) artery for 60 min. the animals were rando ...	2007	17597149
analysis of the full-length genome of hepatitis e virus isolates obtained from farm pigs in mongolia.	although no outbreaks of hepatitis e have been reported in mongolia, a significant proportion of the general population had antibodies to hepatitis e virus (hev). to investigate whether pigs are possible reservoirs of hev in mongolia, serum samples obtained from 243 2- or 3-month-old pigs on four swine farms surrounding ulaanbaatar, the capital city of mongolia, were tested for the presence of anti-hev antibodies and hev rna. overall, 223 pigs (91.8%) tested positive for anti-hev, while 89 pigs ...	2007	17597486
differential anti-influenza activity among allelic variants at the sus scrofa mx1 locus.	a promising way to oppose infectious challenges would be to improve the resistance of the target species through genetic selection. theoretically, a candidate gene is available against influenza viruses since a resistance trait was fortuitously discovered in the a2g mouse strain. this trait was demonstrated to be correlated with the expression of a specific isoform of the type i interferon (ifn)-dependent protein mx, an isoform coded by a specific allele at the mouse mx1 locus. two allelic polym ...	2007	17316142
bloodless laparoscopic liver resection using radiofrequency thermal energy in the porcine model.	the aim of this study was to assess the feasibility and safety of laparoscopic hepatectomy using radiofrequency (rf) thermal energy in a porcine model. fifteen female domestic pigs weighing 29.3 kg (range 25 to 35 kg) were used. five transversal abdominal incisions (3 of 1 cm and 2 of 0.5 cm) were made for the introduction of the video camera and the other laparoscopic instruments. with the porta hepatis not clamped, the liver was inspected and the preferred lobe each time was divided using rf ( ...	2007	17318049
sero-survey on aino, akabane, chuzan, bovine ephemeral fever and japanese encephalitis virus of cattle and swine in korea.	vector-borne arboviruses produce mild to severe symptoms in domestic animals. bovine ephemeral fever (bef), akabane, aino, and chuzan virus have been primarily attributed to reproductive disorders or febrile diseases in cattle, and japanese encephalitis virus (jev) is mainly associated with reproductive failures in swine. we investigated antibody titers from domestic swine against four bovine arboviruses (bef, akabane, aino, and chuzan virus) and from cattle against jev in korea. while the posit ...	2007	17322773
anesthesia for cardiovascular interventions and magnetic resonance imaging in pigs.	large animal models are still required for many experimental purposes. the aim of the current study was to define a viable narcotic procedure for experimental cardiovascular interventions and imaging in pigs. a total of 32 domestic pigs were used. animals received propofol, midazolam, and fentanyl as continuous intravenous infusion anesthesia for complex vascular interventions, angiographic x-ray imaging, and magnetic resonance imaging (mri). anesthesia was maintained for 6 to 10 h. the initial ...	2007	17343350
phylogeny and ancient dna of sus provides insights into neolithic expansion in island southeast asia and oceania.	human settlement of oceania marked the culmination of a global colonization process that began when humans first left africa at least 90,000 years ago. the precise origins and dispersal routes of the austronesian peoples and the associated lapita culture remain contentious, and numerous disparate models of dispersal (based primarily on linguistic, genetic, and archeological data) have been proposed. here, through the use of mtdna from 781 modern and ancient sus specimens, we provide evidence for ...	2007	17360400
genetic variability and evolution of hepatitis e virus.	hepatitis e virus (hev) is the sole member of the genus hepevirus in the family hepeviridae. hev is transmitted primarily by the fecal-oral route, and water-borne epidemics are characteristic of hepatitis e in many developing countries in asia, africa and latin america where sanitation conditions are suboptimal. accumulating lines of evidence indicate that hev-associated hepatitis also occurs domestically among individuals in industrialized countries, that there are animal reservoirs of hev such ...	2007	17363102
optical coherence tomography: a noninvasive method to assess wound reepithelialization.	accurate assessment of wound healing may require invasive tissue biopsies, limiting its clinical usefulness in humans. optical coherence tomography (oct) is a novel, high-resolution method using light reflection to obtain noninvasive cross sectional imaging of biological tissues.	2007	17363766
skin decontamination of mustards and organophosphates: comparative efficiency of rsdl and fuller's earth in domestic swine.	research in skin decontamination and therapy of chemical warfare agents has been a difficult problem due to the simultaneous requirement of rapid action and non-aggressive behaviour. the aim of this study was to compare the performance of two decontaminating systems: the canadian reactive skin decontaminant lotion (rsdl) and the fuller's earth (fe). the experiment was conducted with domestic swine, as a good model for extrapolation to human skin. rsdl and fe were tested against sulphur mustard ( ...	2007	17370872
microbubbles in the pulmonary artery generated during experimental hepatic radiofrequency ablation is correlated with increased pulmonary arterial pressure.	microbubbles in hepatic veins during hepatic radiofrequency (rf) ablation is a well-known observation. in this experimental study, we examined the association between microbubbles in the pulmonary artery and alterations in mean pulmonary arterial pressure (mpap) during hepatic rf ablation with a perfusion electrode system.	2007	17377191
assessment of the lapraty clip for facilitating reconstructive laparoscopic surgery in a porcine model.	to assess the efficacy, reliability, and performance of the lapraty clip (ltc) as a substitute for knot tying during reconstructive surgery in a porcine model.	2007	17382183
assessment of cu-ets as a pet radiopharmaceutical for evaluation of regional renal perfusion.	the copper(ii) complex of ethylglyoxal bis(thiosemicarbazone) (cu-ets) was evaluated as a positron emission tomography (pet) radiopharmaceutical for assessment of regional renal perfusion.	2007	17383574
advances in swine biomedical model genomics.	this review is a short update on the diversity of swine biomedical models and the importance of genomics in their continued development. the swine has been used as a major mammalian model for human studies because of the similarity in size and physiology, and in organ development and disease progression. the pig model allows for deliberately timed studies, imaging of internal vessels and organs using standard human technologies, and collection of repeated peripheral samples and, at kill, detaile ...	2007	17384736
cardiac effects of endothelin receptor antagonism in endotoxemic pigs.	myocardial depression in sepsis is frequently encountered clinically and contributes to morbidity and mortality. increased plasma levels of endothelin-1 (et-1) have been described in septic shock, and previous reports have shown beneficial effects on cardiovascular performance and survival in septic models using et receptor antagonists. the aim of the current study was to investigate specific cardiac effects of et receptor antagonism in endotoxicosis. sixteen domestic pigs were anesthetized and ...	2007	17400719
preweaning housing effects on behavior and physiological measures in pigs during the suckling and fattening periods.	the effect of the preweaning housing system on the stress response of pigs before weaning and during fattening was studied in 33 litters of domestic pigs. three preweaning housing systems were compared: barren crate (standard farrowing crate without straw), enriched crate (20% larger crate, with straw), and as a control, a farrowing pen (pen, 60% larger than the barren crate, with straw). at 25 d of age, pigs were tested with an isolation test and 1 d later with a human approach test (humant). p ...	2007	17400972
high prevalence of unusual genotypes of toxoplasma gondii infection in pork meat samples from erechim, southern brazil.	toxoplasmosis is the most common cause of infectious uveitis in brazil, with a higher frequency in the south of the country. we have collected samples from porcine tongue and diaphragm obtained in both large and small abattoirs and used molecular biological technique to determine the prevalence of infection and rflp analysis to type the parasites. seventeen out of 50 (34%) samples from the diaphragm and 33 out of 50 (66%) samples from the tongue demonstrated a positive pcr reaction for t. gondii ...	2007	17401480
is all ventricular fibrillation the same? a comparison of ischemically induced with electrically induced ventricular fibrillation in a porcine cardiac arrest and resuscitation model.	the standard porcine cardiac arrest model uses electrical induction of ventricular fibrillation. reported restoration of spontaneous circulation and survival rates in this model are as high as 90% for ventricular fibrillation durations of 7-10 mins, values substantially greater than rates in the clinical population (i.e., 20% to 30%). a high first shock success rate, infrequent refibrillation, and short times for restoration of spontaneous circulation are typical of the model. the purpose of thi ...	2007	17414084