Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| Overexpression of histidine-rich calcium binding protein in equine ventricular myocardium. | Histidine-rich calcium binding protein (HRC) is a high capacity, low affinity Ca(2+) binding protein, specifically expressed in striated muscles of mammals. In rabbit skeletal and cardiac muscles, HRC binds to sarcoplasmic reticulum (SR) membranes via triadin, a junctional SR protein. Recently, a potential role in heart failure and arrhythmogenesis has been assigned to HRC due to its activity as regulator of SR Ca(2+) uptake and Ca(2+) release. HRC might play a particularly relevant role in the ... | 2011 | 22040806 |
| Toxicity of essential and non-essential oils against the chewing louse, Bovicola (Werneckiella) ocellatus. | The toxicity of six plant essential oils to the chewing louse, Bovicola (Werneckiella) ocellatus collected from donkeys, was examined in laboratory bioassays. The oils examined were: tea-tree (Melaleuca alternifolia), lavender (Lavandula angustifolia), peppermint (Mentha piperita), eucalyptus (Eucalyptus globulus Labillardiere), clove bud (Eugenia caryophyllata) and camphor (Cinnamomum camphora). All except camphor oil showed high levels of toxicity, with significant dose-dependent mortality and ... | 2011 | 22177577 |
| synthesis, characterisation and biological evaluation of copper and silver complexes based on acetylsalicylic acid. | metalcarbonyl complexes with ligands derived from acetylsalicylic acid demonstrated high cytotoxic potential against various tumor cell lines and strong inhibition of the cyclooxygenase enzymes cox-1 and 2. in this study we tried to achieve comparable effects with [alkyne]silver or copper trifluoromethanesulfonate complexes which are more hydrophilic then the uncharged metalcarbonyl derivatives. all compounds were evaluated for growth inhibition against breast (mcf-7, mda-mb 231) and colon cance ... | 2011 | 21984018 |
| effects of transcranial direct current stimulation of the primary sensory cortex on somatosensory perception. | transcranial direct current stimulation (tdcs) is able to modify cortical excitability and activity in humans. | 2011 | 22032740 |
| PARTIAL DELETION OF ARGININOSUCCINATE SYNTHASE PROTECTS FROM PYRAZOLE PLUS LIPOPOLYSACCHARIDE-INDUCED LIVER INJURY BY DECREASING NITROSATIVE STRESS. | Background & Aim: Argininosuccinate synthase is the rate-limiting enzyme in the urea cycle. Along with nitric oxide synthase-2, argininosuccinate synthase endows cells with the L-citrulline/nitric oxide salvage pathway to continually supply L-arginine from L-citrulline for sustained nitric oxide generation. Because of the relevant role of nitric oxide synthase-2 in liver injury, we hypothesized that down-regulation of argininosuccinate synthase could decrease the availability of intracellular su ... | 2011 | 22052013 |
| short-term and long-term outcome of anti-jo1-positive patients with anti-ro52 antibody. | objectives: the aims of the present study were to (1) assess clinical features and long-term outcome in anti-jo1-positive patients with anti-ro52 antibody; (2) compare characteristics of anti-jo1-positive patients with and without anti-ro52 antibody; and (3) compare features of anti-ro52-positive patients with and without anti-jo1 antibody. methods: the medical records of 89 consecutive anti-jo1-positive patients with antisynthetase syndrome (ass) were reviewed; 36 of these patients had coexiste ... | 2011 | 22078416 |
| mri apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade ii gliomas. | the apparent diffusion coefficient (adc) determined from mr diffusion tensor imaging (dti) has shown promise for distinguishing world health organization grade ii astrocytoma (as) from the more prognostically favorable grade ii oligodendroglioma (od). since mixed oligoastrocytomas (oas) with codeletions in chromosomes 1p and 19q confer prognoses similar to those of od, we questioned whether a previously determined adc-based criterion for distinguishing od and as would hold on an independent set ... | 2011 | 21865401 |
| arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat. | background/aims: reduced renal l-arginine (l-arg) synthesis/transport, induction of arginases and increased endogenous nos inhibitor, asymmetric dimethylarginine (adma) will inhibit no production. this study investigated pathways of l-arg synthesis/uptake/utilization, adma degradation and oxidant/antioxidants in puromycin aminonucleoside (pan) chronic kidney disease (ckd). methods: rats were given low- (ld) or high-dose (hd) pan and followed for 11 weeks for proteinuria. bp was measured and bloo ... | 2011 | 22179117 |
| xuhuai goat h-fabp gene clone, subcellular localization of expression products and the preparation of transgenic mice. | the aim of this study was to clone the heart-type fatty acid binding protein (h-fabp) gene of xuhuai goat, to explore it bioinformatically, and analyze the subcellular localization using enhanced green fluorescent protein (egfp). the results showed that the coding sequence (cds) length of xuhuai goat h-fabp gene was 402 bp, encoding 133 amino acids (genbank accession number ay466498.1). the h-fabp cdna coding sequence was compared with the corresponding region of human, chicken, brown rat, cow, ... | 2011 | 22149926 |
| tricyclodecan-9-yl-xanthogenate (d609) mechanism of actions: a mini-review of literature. | tricyclodecan-9-yl-xanthogenate (d609) is known for its antiviral and antitumor properties. d609 actions are widely attributed to inhibiting phosphatidylcholine (pc)-specific phospholipase c (pc-plc). d609 also inhibits sphingomyelin synthase (sms). pc-plc and/or sms inhibition will affect lipid second messengers 1,2-diacylglycerol (dag) and/or ceramide. evidence indicates either pc-plc and/or sms inhibition affected the cell cycle and arrested proliferation, and stimulated differentiation in va ... | 2011 | 22101393 |
| potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis e virus in human and various animals in beijing, china. | the aim of this study was to further investigate the prevalence of infection and genotype of hepatitis e virus (hev) among different species of animals, people whose works are related to pigs and the general population in the suburb of beijing, china. serum and faecal samples were collected from 10 animal species and humans. anti-hev was detected by enzyme immunoassays (eia); hev rna was amplified by reverse transcription-nested polymerase chain reaction (rt-npcr) method. pcr products were clone ... | 2011 | 21914080 |
| occurrence of water-borne enteric viruses in two settlements based in eastern chad: analysis of hepatitis e virus, hepatitis a virus and human adenovirus in water sources. | hepatitis e virus (hev) is a common cause of water-borne acute hepatitis in areas with poor sanitation. in 2004 an outbreak of hev infection affected around 2,000 people in eastern chad (dar sila). this paper describes the decrease in the incidence of acute jaundice syndrome (ajs) from 2004 until 2009 when a mean incidence of 0.48 cases/1,000 people/year was recorded in the region. outbreaks of ajs were identified in some of the camps in 2007 and 2008. moreover, water samples from drinking water ... | 2011 | 21976198 |
| stable overexpression of arginase i and ornithine transcarbamylase in hepg2 cells improves its ammonia detoxification. | hepg2 is an immortalized human hepatoma cell line that has been used for research into bioartificial liver systems. however, a low level of ammonia detoxification is its biggest drawback. in this work, a recombinant hepg2 cell line with stable overexpression of human arginase i (hargi) and human ornithine transcarbamylase (hotc), hepg2/(hargi + hotc)4, was developed using a eukaryotic dual gene expression vector pbudce4.1. □ the hargi and hotc enzymatic activity in hepg2/(hargi + hotc)4 cells we ... | 2011 | 21938740 |
| [in vivo and in vitro effect of peptide hp-6 derived from donkey serum albumin on hematopoietic system]. | by bioinformatics method, the effect in hematopoietic system of bioactive peptide hp-6, which was obtained from donkey serum albumin and is one of the major protein components from donkey-hide gelatin, was investigated. | 2011 | 22097343 |
| splicing analysis of unclassified variants in col2a1 and col11a1 identifies deep intronic pathogenic mutations. | uk nhs diagnostic service sequence analysis of genes generally examines and reports on variations within a designated region 5' and 3' of each exon, typically 30 bp up and downstream. however, because of the degenerate nature of the splice sites, intronic variants outside the ag and gt dinucleotides of the acceptor and donor splice sites (ass and dss) are most often classified as being of unknown clinical significance, unless there is some functional evidence of their pathogenicity. it is now be ... | 2011 | 22189268 |
| comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. | the sensitivity and specificity of three commercially available complement fixation test (cft) antigens from c.c.pro (c.c.pro), central veterinary institute of wageningen ur (cidc) and the united states department of agriculture (usda) were comparatively evaluated by testing 410 sera collected from glanders-endemic and non-endemic areas (200 true-negative randomly collected sera and 210 sera collected from experimentally immunised animals (12 rabbits, 19 horses), clinically positive (135) and cu ... | 2011 | 21896565 |
| molecular and serological detection of theileria equi and babesia caballi in donkeys (equus asinus) in brazil. | piroplasmosis in donkeys has been recognized as a serious problem of major economic importance, since the affected animals manifest loss of appetite and decreased working capacity. the present work is aimed at detecting infection or exposure of donkeys in são paulo, brazil to theileria (t.) equi and babesia (b.) caballi using molecular and serological approaches. edta-blood and serum samples were collected from 88 donkeys (equus asinus). from 88 sampled donkeys, 65 (73.86%; 95% confidence interv ... | 2011 | 22186194 |
| plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys. | to investigate plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys. | 2011 | 22126692 |
| the epidemiology of cranio-facial injuries caused by animals in southern-central china. | a clinical investigation was conducted to demonstrate the epidemiology of cranio-facial injuries inflicted by animals in southern-central part of china-the world's most populous eastern country. it consisted of a retrospective study of 149 patients and was carried out in our department. all the patients were attacked by animals, such as buffalo, cattle, donkey, horse, dog, cat, and rat. there were 91 males and 58 females patients, aged from 5 to 65 years. 113 patients were from rural areas, and ... | 2011 | 21925891 |
| Gasterophilosis: a major cause of rectal prolapse in working donkeys in Ethiopia. | A retrospective study was conducted to investigate the cause of rectal prolapse in working donkeys in Ethiopia. Analysis of data on rectal prolapse cases obtained from the Donkey Health and Welfare Project clinic at the School of Veterinary Medicine, Addis Ababa University, from 1995 to 2004 revealed that 83.6% (n?=?177) of the cases were associated with Gasterophilus nasalis. The rest 10.7% and 5.7% were associated with work-related (overloading) cause and diarrhoea, respectively. The mean and ... | 2011 | 21870062 |
| cavity enhanced stimulated brillouin scattering in an optical chip for multiorder stokes generation. | we report the first demonstration of on-chip cascaded stimulated brillouin scattering (sbs). cascaded sbs is characterized in a 4 cm long chalcogenide (as₂s₃) rib waveguide where the end facet reflections provide a monolithic fabry-perot (fp) resonator. the presence of the fp cavity reduces the brillouin gain threshold, which enables observation of cascaded sbs at reduced pump powers. we observe up to three orders of stokes waves in the backscattered signal at a coupled peak power of 1.34 w. ant ... | 2011 | 21931433 |
| arginine or citrulline associated with a statin stimulates nitric oxide production in bovine aortic endothelial cells. | nitric oxide (no) is an antiatherogenic vasodilator synthesized from arginine and, indirectly, from citrulline through argininosuccinate synthase (ass) and argininosuccinate lyase (asl). hypercholesterolemia-induced atherosclerosis is usually treated by statins, which decrease cholesterolemia and increase endothelial no synthase (enos) activity. therefore, a treatment associating a statin with arginine or citrulline could be more efficient than statin alone. the aim of this study was to optimize ... | 2011 | 21914450 |
| Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase. | Background:Some cancers have been shown to lack expression of argininosuccinate synthetase (ASS), an enzyme required for the synthesis of arginine and a possible biomarker of sensitivity to arginine deprivation. Arginine deiminase (ADI) is a microbial enzyme capable of efficiently depleting peripheral blood arginine.Methods:Argininosuccinate synthetase expression was assessed in human small cell lung cancer (SCLC) by immunohistochemistry (IHC), with expression also assessed in a panel of 10 huma ... | 2011 | 22134507 |
| combined lysosomal protein transmembrane 4 beta-35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients. | the newly-identified lysosomal protein transmembrane 4 beta-35 (laptm4b-35) plays important roles in tumor progression and metastasis, while argininosuccinate synthetase (ass) provides arginine as an indispensable nutrient for hepatocellular carcinoma (hcc). the present study investigated the clinical significance of the coexpression of laptm4b-35 and ass in hcc patients on determining the prognosis. | 2011 | 21626328 |
| sildenafil restores cognitive function without affecting aß burden in an alzheimer's disease mouse model. | background and purpose: phosphodiesterase (pdes) 5 inhibitors regulate signaling pathways by elevating cgmp, which is a second messenger involved in processes of neuroplasticity. in the present study, the effect of the administration of the pde 5 inhibitor, sildenafil, on the pathological hallmarks of the alzheimer's disease and on memory-related behavior were investigated. experimental approach: sildenafil was administered to the tg2576 transgenic mouse model of alzheimer's disease and to age-m ... | 2011 | 21627640 |
| ass(2)cl-an arsenic(v) compound? formation, stability and structure of gaseous asscl and ass(2)cl-a combined experimental and theoretical study. | by reaction of solid as(4)s(4) with gaseous cl(2) at a temperature of 410 k gaseous asscl and ass(2)cl are formed. unexpectedly in ass(2)cl the arsenic is not of formal oxidation state +v but +iii: the molecular structure of ass(2)cl is arranged as a 1-chloro-dithia-arsirane and comprises an hitherto unknown ass(2) three-membered ring. thermodynamic data on asscl and ass(2)cl are obtained by mass spectrometry (ms). the experimental data are extended and confirmed by ab initio quantum chemical ca ... | 2011 | 21629882 |
| radiological anatomy of the donkey's foot: objective characterisation of the normal and laminitic donkey foot. | reasons for performing study: anatomical change within a laminitic foot is of diagnostic and prognostic importance. a lateromedial radiograph represents the current 'gold standard' by which these changes are identified. detection of anatomical change is dependent upon a priori knowledge of normality and subjective assessment alone may not identify modest change. normal baseline data is, therefore, needed against which objective comparisons can be made. there is little information regarding the r ... | 2011 | 21631583 |
| the role of working equines to livelihoods in current day campesino hill-slope communities in central mexico. | small-holder campesino agriculture is based on the diversified use of resources and off-farm work. working equines have a multifunctional character and sustain the diversification of livelihoods having different values as assets or providing services. the objective was to identify the role of working equines in current diversification strategies in the livelihoods of campesino families in a hill-slope community in central mexico within livelihoods analysis. thirty-one variables related to owners ... | 2011 | 21637993 |
| poppea's bath liquor: the secret proteome of she-donkey's milk. | donkey's milk is today categorized among the best mother's milk substitute for allergic newborns, due to its much reduced or absent allergenicity, coupled to excellent palatability and nutritional value. however, up to the present, only a handful of proteins had been characterized, just about the standard eight to ten major ones known in all types of milk. by exploiting the combinatorial peptide ligand library technology, and treating large volumes (up to 300ml) of defatted, de-caseinized (whey) ... | 2011 | 21645650 |
| alternative stable states and phase shifts in coral reefs under anthropogenic stress. | ecosystems with alternative stable states (ass) may shift discontinuously from one stable state to another as environmental parameters cross a threshold. reversal can then be difficult due to hysteresis effects. this contrasts with continuous state changes in response to changing environmental parameters, which are less difficult to reverse. worldwide degradation of coral reefs, involving "phase shifts" from coral to algal dominance, highlights the pressing need to determine the likelihood of di ... | 2011 | 21661558 |
| stability of behavioral estimates of activity-dependent modulation of pain. | temporal sensory summation of pain (tssp) is a proxy measure of windup in humans and results in increased ratings of pain caused by a repetitive, low-frequency noxious stimulus. aftersensations (ass) are pain sensations that remain after tssp has been induced. we examined the within-session and across-session variability in tssp and as estimation in healthy participants and in participants with exercise-induced muscle pain in order to determine whether the presence of pain affected the stability ... | 2011 | 21811390 |
| a gene catalogue of the euchromatic male-specific region of the horse y chromosome: comparison with human and other mammals. | studies of the y chromosome in primates, rodents and carnivores provide compelling evidence that the male specific region of y (msy) contains functional genes, many of which have specialized roles in spermatogenesis and male-fertility. little similarity, however, has been found between the gene content and sequence of msy in different species. this hinders the discovery of species-specific male fertility genes and limits our understanding about msy evolution in mammals. here, a detailed msy gene ... | 2011 | 21799735 |
| successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases. | reasons for performing study: sarcoids are the commonest form of equine skin tumour. several therapeutic measures have been described but none is considered to be universally effective. electrochemotherapy (ect) is a new anticancer therapy that utilises electrical field pulses to induce increased cell membrane permeability to antitumour hydrophilic drugs, such as cisplatin. the increased intracellular concentration of the drugs has a significant therapeutic benefit. the procedure has not been pr ... | 2011 | 21793876 |
| pharmacogenetics of escitalopram and mental adaptation to cancer in palliative care: report of 18 cases. | aims and background. in palliative care, few data are available on the diagnosis and treatment of mood disorders and of difficulties of mental adaptation to cancer for patients in the advanced phases of the disease. ssri antidepressants are the treatment of choice; the 5-httlpr genetic polymorphism of the serotonin transporter (sert) has been shown in psychiatry to significantly determine the therapeutic response and the incidence of adverse effects. the aim of the present investigation has been ... | 2011 | 21789016 |
| detection of cow milk in donkey milk by chemometric procedures on triacylglycerol stereospecific analysis results. | stereospecific analysis is an important tool for the characterization of lipid fraction of food matrices, and also of milk samples. the results of a chemical-enzymatic-chromatographic analytical method were elaborated by chemometric procedures such as linear discriminant analysis (lda) and artificial neural network (ann). according to the total composition and intrapositional fatty acid distribution in the triacylglycerol (tag) backbone, the obtained results were able to characterize pure milk s ... | 2011 | 21774859 |
| chromosomal assignment of six genes (eif4g3, hsp90, rbbp6, il8, tert, and terc) in four species of the genus equus. | we mapped six genes (eif4g3, hsp90, rbbp6, il8, tert, and terc) on the chromosomes of equus caballus, equus asinus, equus grevyi, and equus burchelli by fluorescence in situ hybridization. our results add six type i markers to the cytogenetic map of these species and provide new information on the comparative genomics of the genus equus. | 2011 | 21774619 |
| nandrolone and stanozolol induce leydig cell tumor proliferation through an estrogen-dependent mechanism involving igf-i system. | several substances such as anabolic androgenic steroids (aas), peptide hormones like insulin-like growth factor-i (igf-i), aromatase inhibitors and estrogen antagonists are offered via the internet, and are assumed without considering the potential deleterious effects that can be caused by their administration. in this study we aimed to determine if nandrolone and stanozolol, two commonly used aas, could have an effect on leydig cell tumor proliferation and if their effects could be potentiated ... | 2011 | 21769864 |
| aldosterone induces electrical remodeling independent of hypertension. | background: treatment of heart failure patients with aldosterone antagonists has been shown to reduce the occurrence of sudden cardiac death. therefore we aimed at determining the consequences of chronic exposure to aldosterone and the aldosterone antagonists eplerenone and spironolactone on the electrophysiological properties of the heart in a rat model. methods and results: male wistar rats were chronically treated (4weeks) with aldosterone (ald) via an osmotic minipump. spironolactone (spi) o ... | 2011 | 21764470 |
| unexpected stable dimerisation of an anionic imidopyrrolecarboxylate in polar solution. | the imidopyrrolecarboxylate 3(-) unexpectedly forms stable dimers (k(ass) = 130 m(-1) in chcl(3)/dmso, 1?:?1, v/v) despite the fact that two anions have to interact. the dimer is more stable than an analogous neutral amidopyrrolecarboxylic acid dimer (k(ass) < 10 m(-1)) underlining the importance of charged h-bonds compared to neutral ones. | 2011 | 21761036 |
| polymorphic organization of constitutive heterochromatin in equus asinus (2n = 62) chromosome 1. | in the karyotype of equus asinus (domestic donkey, 2n = 62), non-centromeric heterochromatic bands have been described in subcentromeric and telomeric positions. in particular, chromosome 1 is characterised by heterochromatic bands in the proximal region of the long arm and in the short arm; it has been shown that these regions are polymorphic in size. here we investigated the variation in the intensity and distribution of fluorescence signals observed on donkey chromosome 1 after in situ hybrid ... | 2011 | 21756256 |
| serum metal ion levels after rotating-hinge knee arthroplasty: comparison between a standard device and a megaprosthesis. | purpose: the effects of systemic metal ion exposure in patients with implants made of common prosthetic alloys continue to be a matter of concern. the aim of the study was to determine the measurement values of cobalt (co), chromium (cr) and molybdenum (mo) in serum following rotating-hinge knee arthroplasty. methods: blood was taken from 25 patients [mean follow-up 35 (range nine to 67) months] treated with megaprostheses (n=17) or standard rotating-hinge devices (n=8) and analysed using electr ... | 2011 | 21755331 |
| innovative zoning to support equine influenza eradication from new south wales, australia. | following detection of equine influenza (ei) in new south wales, a complete standstill was imposed the next morning on the movement of all horses and donkeys within the state. premises' biosecurity guidelines became progressively more stringent with time in an effort to stop local spread. the standstill was highly effective as a primary response to stop ei becoming widespread across australia, but did not prevent spread to properties contiguous to infected premises in areas of high horse density ... | 2011 | 21711306 |
| vertebral artery injuries following cervical spine trauma: a prospective observational study. | purpose: the purpose of this study was to report on the incidence, diagnosis and clinical manifestation of vai following cervical spine injuries observed in a prospective observational study with a standardized clinical and radiographical protocol. methods: during a 16-year period, 69 (mean age: 43-á-¦-á20.7-áyears; 25 female, 44 male) of 599 patients had cervical spine injury suspicious for vai due to facet luxation and/or fractures extending into the transverse foramen. diagnosis and managemen ... | 2011 | 21717238 |
| surveillance programme for important equine infectious respiratory pathogens in the usa. | the prevalence and epidemiology of important viral (equine influenza virus [eiv], equine herpesvirus type 1 [ehv-1] and ehv-4) and bacterial (streptococcus equi subspecies equi) respiratory pathogens shed by horses presented to equine veterinarians with upper respiratory tract signs and/or acute febrile neurological disease were studied. veterinarians from throughout the usa were enrolled in a surveillance programme and were asked to collect blood and nasal secretions from equine cases with acut ... | 2011 | 21676986 |
| cascaded raman shifting of high-peak-power nanosecond pulses in asôéésôéâ and asôééseôéâ optical fibers. | we report efficient cascaded raman scattering of near-ir nanosecond pulses in large-core (65 ++m diameter) asôéésôéâ and asôééseôéâ optical fibers. raman scattering dominates other spectral broadening mechanisms, such as four-wave mixing, modulation instability, and soliton dynamics, because the fibers have large normal group-velocity dispersion in the spectral range of interest. with ~2 ns pump pulses at a wavelength of 1.9 ++m, four stokes peaks, all with peak powers greater than 1 kw, have be ... | 2011 | 21686017 |
| mitochondrial genome sequence of the tibetan wild ass (equus kiang). | the tibetan wild ass, or kiang (equus kiang) is endemic to the cold and hypoxic (4000-7000-ám above sea level) climates of the montane and alpine grasslands of the tibetan plateau. we report here the complete nucleotide sequence of the e. kiang mitochondrial genome. our results show that e. kiang mitochondrial dna is 16,634-ábp long, and predicted to encode all the 37 genes that are typical for vertebrates. | 2011 | 21732718 |
| activation of pkr causes amyloid ß-peptide accumulation via de-repression of bace1 expression. | bace1 is a key enzyme involved in the production of amyloid ß-peptide (aß) in alzheimer's disease (ad) brains. normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'utr) in the bace1 promoter. bace1 expression is activated by phosphorylation of the eukaryotic initiation factor (eif)2-alpha, which reverses the inhibitory effect exerted by bace1 5'utr. there are four kinases associated with different types of stress that could phosphorylate eif2 ... | 2011 | 21738672 |
| african horse sickness in the gambia: circulation of a live-attenuated vaccine-derived strain. | summaryafrican horse sickness virus serotype 9 (ahsv-9) has been known for some time to be circulating amongst equids in west africa without causing any clinical disease in indigenous horse populations. whether this is due to local breeds of horses being resistant to disease or whether the ahsv-9 strains circulating are avirulent is currently unknown. this study shows that the majority (96%) of horses and donkeys sampled across the gambia were seropositive for ahs, despite most being unvaccinate ... | 2011 | 21733265 |
| human scca serpins inhibit staphylococcal cysteine proteases by forming classic "serpin-like" covalent complexes. | proteolytic enzymes secreted by staphylococcus aureus are considered important virulence factors. here, we present data showing that staphylococci-derived cysteine proteases (staphopains) are efficiently inhibited by squamous cell carcinoma antigen 1 (scca1), a serpin abundant on the epithelial surfaces. the high association rate constant (k(ass)) for inhibitory complex formation (1.9 +ù 10ôü¦ and 5.8 +ù10ôü¦ môü+-¦ sôü+-¦ for staphopain a and staphopain b interaction with scca1, respectively) a ... | 2011 | 21683261 |
| adventitious sounds identification and extraction using temporal-spectral dominance based features. | respiratory sound (rs) signals carry significant information about the underlying functioning of the pulmonary system by the presence of adventitious sounds (ass). although many studies have addressed the problem of pathological rs classification, only a limited number of scientific works have focused in the analysis of the evolution of symptom related signal components in joint time-frequency (tf) plane. this paper proposes a new signal identification and extraction method for various ass based ... | 2011 | 21712152 |
| coagulation profiles of healthy andalusian donkeys are different than those of healthy horses. | coagulation disorders are frequently diagnosed, especially in hospitalized equidae, and result in increased morbidity and mortality. however, hemostatic reference intervals have not been established for donkeys yet. | 2011 | 21736621 |
| space availability influence laterality in donkeys (equus asinus). | cerebral lateralization is the portioning of the cognitive functions between the two cerebral hemispheres. several factors, like embryological manipulations, light exposure, health conditions, sex and age can influence the left-right brain asymmetries and contribute to increasing the variability in the strength and direction of laterality within most species. we investigated the influence of an environmental constraint, namely space availability, as a new source of variation on laterality in an ... | 2011 | 21741459 |
| Activation of a7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus. | Nicotinic acetylcholine receptors mediate fast cholinergic modulation of glutamatergic transmission and synaptic plasticity. Here we investigated the effects of subtype selective activation of the a7 nicotinic acetylcholine receptors on hippocampal transmission and the inhibition of synaptic long-term potentiation by the Alzheimer's disease associated amyloid ß-protein (Aß). The a7 nicotinic acetylcholine receptor agonist "compound A" ((R)-N-(1-azabicyclo[2.2.2]oct-3-yl)(5-(2-pyridyl))thiophene- ... | 2011 | 22200627 |
| ultrasonographic features of the mule embryo, fetus and fetal-placental unit. | the aim of this study was to establish baseline ultrasound data concerning the mule conceptus during gestation. ten multiparous trotter mares were artificially inseminated with chilled semen from an amiatino jack donkey. daily transrectal ultrasonography was carried out from the day of ovulation until day 50 of gestation to determine the following: first detection of the embryonic vesicle (ev), mobility phase, ev diameter, day of ev fixation, changes in ev shape, date of yolk sac regression and ... | 2011 | 21958639 |
| Nutritional Stress and Arginine Auxotrophy Confer High Sensitivity to Chloroquine Toxicity in Mesothelioma Cells. | The correlation between cells' sensitivity to autophagy inhibitors such as chloroquine (CQ) and the expression/activity of molecules involved in the control and execution of autophagy is well documented. However, tumor cells with comparable autophagic potentials may display variable degrees of autophagy addiction due to the differential expression of molecular determinants still scarcely defined. In this study we investigated the effects of CQ on growth, death and autophagic activity of malignan ... | 2011 | 22074703 |
| sources and leaching of manganese and iron in the saigon river basin, vietnam. | high concentrations of manganese and iron in the saigon river are major problems for the water supply in ho chi minh city (hcmc), viet nam. to identify their sources and leaching processes, we surveyed water quality along the saigon river and ran batch leaching tests using soil and sediment samples. two important leaching processes were identified: acidic leaching from acid sulfate soil (ass) in the middle reaches of the river, and mn dissolution and fe reduction from sediments in the downstream ... | 2011 | 21977643 |
| Psychological essentialist reasoning and perspective taking during reading: A donkey is not a zebra, but a plate can be a clock. | In an eyetracking study, we examined whether readers use psychological essentialist reasoning and perspective taking online. Stories were presented in which an animal or an artifact was transformed into another animal (e.g., a donkey into a zebra) or artifact (e.g., a plate into a clock). According to psychological essentialism, the essence of the animal did not change in these stories, while the transformed artifact would be thought to have changed categories. We found evidence that readers use ... | 2011 | 22037846 |
| hyperlipemia in a population of aged donkeys: description, prevalence, and potential risk factors. | hyperlipemia is a common disorder of the donkey, with mortality rates of up to 80% reported. such a poor prognosis makes prevention of this disorder or amelioration in the early stages crucial. | 2011 | 22092637 |
| donkey-assisted rehabilitation program for children: a pilot study. | bonding with animals grants access to the sphere of affectivity and facilitates therapeutic engagement. the methodological approach of donkey-assisted programs is based on mediation, which is characterized by multidirectional relationships (patient-donkey-therapist). the donkey is an excellent facilitator in the motivation-building process, being able to stimulate the child's development by way of active and positive forces that foster psycho-affective and psycho-cognitive development processes. ... | 2011 | 22194074 |
| lactation curve and effects of milking regimen on milk yield and quality, and udder health in martina franca jennies (equus asinus). | three experiments were conducted on martina franca jennies. experiment 1 tested wood's model for evaluating the lactation curve. data from the entire lactation period of 12 jennies were used. the results showed that wood's model was able to recognize the shape of the lactation curve from pooled data (r(2) = 0.11; p < 0.01), with the lactation peak occurring at 48 d. individual curves showed wide variability. experiment 2 aimed to evaluate the effects of the daily number of milkings (1, 3, or 6) ... | 2011 | 21965450 |
| x-ray absorption and photoelectron spectroscopic study of the association of as(iii) with nanoparticulate fes and fes-coated sand. | iron sulfide (fes) has been demonstrated to have a high removal capacity for arsenic (as) in reducing environments. however, fes may be present as a coating, rather than in nanoparticulate form, in both natural and engineered systems. frequently, the removal capacity of coatings may be different than that of nanoparticulates in batch systems. to assess the differences in removal mechanisms between nanoparticulate fes and fes present as a coating, the solid phase products from the reaction of as( ... | 2011 | 21911241 |
| Pig specific vascular anatomy allows acute infrarenal aortic occlusion without hind limb ischemia and stepwise occlusion without clinical signs. | In a porcine, aortic graft model we found 5 animals to develop and survive unnoticed, complete infrarenal aortic occlusion and 2 pigs with an acute occlusion but rather unspecific clinical symptoms. We investigated the pigs' vascular system to classify the anatomic capabilities to compensate for an acute abdominal aortic occlusion. | 2011 | 21876245 |
| increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. | we sought to determine whether the aryl hydrocarbon receptor (ahr) and interleukin (il)-22 may be involved in the pathogenesis of the peripheral blood mononuclear cells (pbmcs) in allergic asthmatic patients and whether their expression may be related to the severity of the disease. | 2011 | 22053597 |
| differential proteomic analysis of renal tissue in lupus nephritis using itraq reagent technology. | in clinical practice, it is difficult to monitor the repeating relapse in patients suffering from systemic lupus erythematosus (sle), who usually associated with some potential complications, for example, lupus nephritis (ln), repetition renal biopsy is necessary to determine ln flares. to identify and quantify the total proteins in renal tissue of ln patients, isobaric tags for relative and absolute quantification (itraq) technology was performed. eight-plex itraq coupled with multiple chromato ... | 2011 | 22083613 |
| argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice. | background and aim: argininosuccinate synthase (ass) is the rate-limiting enzyme in both the urea and the l-citrulline/nitric oxide (no·) cycles regulating protein catabolism, ammonia levels and no· generation (1-2). since a proteomics analysis identified ass and nitric oxide synthase-2 (nos2) as co-induced in rat hepatocytes by chronic ethanol consumption, which also occurred in alcoholic liver disease (ald) and in cirrhotic patients, we hypothesized that ass could play a role in ethanol binge ... | 2011 | 22213272 |
| pathological, immunological and molecular diagnosis of rabies in clinically suspected animals of different species using four detection techniques in jordan. | a total of 29 brain tissue samples (bts) were examined for rabies infection by different diagnostic techniques. none of the examined brain tissues were presented as a whole intact brain. twenty-seven brain tissue samples from various animal species - dog (13 cases), cat (one case), fox (one case), pig (one case), cow (three cases), sheep (two cases), goat (one case), camel (one case), horse (one case) and donkey (three cases) - were provided by the vaccine and sera department/al-bashir central h ... | 2011 | 22390575 |
| a serological survey of cystic echinococcosis in equids in east of turkey. | background: cystic echinococcosis (ce), caused by hydatid cysts, is a widespread and hazardous disease in humans and animals worldwide. the disease is very common in turkey, causing serious economic losses and public health problem. in this study, the seroprevalence of equine ce was determined by enzyme-linked immunosorbent assay (elisa). methods: partially purified cyst fluid antigen from sheep hydatid cyst fluid was used as antigen in elisa. a total of 250 equids consisting of 206 donkeys and ... | 2011 | 22347313 |
| Association constants and distribution functions for ion pairs in binary solvent mixtures: application to a cyanine dye system. | The computations of the association constants K(ass) were performed at the microscopic level for the ion pair Cy(+)I(-) composed of the complex cyanine dye cation Cy(+) coupled to the negative iodine counterion. The wide array of K(ass) values is arranged by a variation of the composition of the binary solvent mixtures toluene/dimethylsulfoxide with the accompanying change of the solvent polarity. The potentials of mean force (PMFs) are calculated for a set of interionic separations R in the Cy( ... | 2011 | 22010723 |
| A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. | Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (Aß) that mediates familial Alzheimer's disease pathology. However, given that age is the greatest risk factor for AD, we explored an alternative drug discovery scheme that is based upon efficacy in multiple cell culture models of age-associated pathologies rather than exclusively a ... | 2011 | 22194796 |
| cytotoxicity and glycan-binding profile of a d-galactose-binding lectin from the eggs of a japanese sea hare (aplysia kurodai). | a divalent cation-independent 16 kda d-galactose binding lectin (akl-2) was isolated from eggs of sea hare, aplysia kurodai. the lectin recognized d-galactose and d-galacturonic acid and had a 32 kda dimer consisting of two disulfide-bonded 16 kda subunits. eighteen n-terminus amino acids were identified by edman degradation, having unique primary structure. lectin blotting analysis with horseradish peroxidase-conjugated lectins has shown that akl-2 was a glycoprotein with complex type oligosacc ... | 2011 | 21953532 |
| relationships between the dynamics of iatrogenic dna damage and genomic design in mammalian spermatozoa from eleven species. | the dynamic onset of dna fragmentation in mammalian sperm populations varies widely in different species when the spermatozoa are incubated in vitro at body temperature for several hours, and recent studies have shown that the dynamic rate of dna fragmentation within a species has considerable predictive value in terms of fertility. the reasons for such variation are unclear, but here we show that differences in protamine sequence and identity could be partially responsible. sets of 10 normal se ... | 2011 | 21919111 |
| differences between epididymal and ejaculated sperm characteristics in donkey. | spermatozoa acquire their motility and fertilizing ability during their passage through the epididymal canal. in the epididymal caput and corpus spermatozoa undergo several biochemical and metabolic changes while the cauda of the epididymis should be considered as the primarily site for storage of the spermatozoa. in the horse spermatozoa from cauda epididymis were collected and frozen, and the fertility of semen assessed. however, no studies have detailed semen characteristics of spermatozoa co ... | 2011 | 21996580 |
| ethanolamine oleate in resistant idiopathic achalasia: a novel therapy. | idiopathic achalasia (ia) is a chronic disease without definite therapy. ethanolamine oleate (eo) has multiple biological effects, including inflammatory activities. we investigated the efficacy of eo injection in selected patients with ia. | 2011 | 21971376 |
| Corneal penetration of topical and subconjunctival bevacizumab. | To investigate the ability of bevacizumab to penetrate the cornea after topical application or subconjunctival injection. | 2011 | 22003112 |
| reliability and construct validity of the bahasa malaysia version of transtheoretical model (ttm) questionnaire for smoking cessation and relapse among malaysian adult. | the transtheoretical model (ttm) has been used as one of the major constructs in developing effective cognitive behavioural interventions for smoking cessation and relapse prevention, in western societies. this study aimed to examine the reliability and construct validity of the translated bahasa malaysia version of ttm questionnaire among adult smokers in klang valley, malaysia. the sample consisted of 40 smokers from four different worksites in klang valley. a 26-item ttm questionnaire was adm ... | 2011 | 22126478 |
| trichophyton bullosum: a new zoonotic dermatophyte species. | we report the first human case of dermatophytosis caused by trichophyton bullosum in a 21-year-old male who had a skin lesion located on his forearm. the dermatophyte was isolated in culture and further identified by sequence analysis of internal transcripted spacer regions. the species t. bullosum is a zoophilic dermatophyte rarely isolated from the coat of horses in africa and asia. in the present case, it was probably transmitted by contact with an infected donkey in a rural area in france. a ... | 2011 | 21905949 |
| disease progression and treatment response of idiopathic epilepsy in australian shepherd dogs. | idiopathic epilepsy (ie) in australian shepherds (ass) occurs worldwide but there is a lack of description of the epilepsy syndrome in this breed. the abcb1-1δ mutation is more prevalent in ass than in many other dog breeds. | 2011 | 22182230 |
| Colonization of turbot tissues by virulent and avirulent Aeromonas salmonicida subsp. salmonicida strains during infection. | Preventing disease outbreaks in cultured turbot Psetta maxima L. caused by Aeromonas salmonicida subsp. salmonicida (ASS) requires a better understanding of how this pathogen colonizes its host. Distribution of 1 virulent and 2 avirulent ASS strains in turbot tissues was investigated during early and late stages of infection following an immersion challenge. To track bacteria within the turbot, the ASS strains were tagged with green fluorescent protein (GFP). Both virulent and avirulent strains ... | 2011 | 21848125 |
| chronological age impacts immunotherapy and monocyte uptake independent of amyloid load. | one vexing issue in biomedical research is the failure of many therapies to translate from success in animal models to effective treatment of human disease. one significant difference between the animal models and the human disease is the age of the subject. cancer, stroke and alzheimer's occur mainly in humans beyond the 75% mean survival age, while most mouse models use juvenile or young adult animals. here we compare two mouse models of amyloid deposition, the tg2576 app model and the more ag ... | 2011 | 22198698 |
| embryo quality and transcervical technique are not the limiting factors in donkey embryo transfer outcome. | embryo transfer (et) in the donkey resulted in a very low recipient pregnancy rates. the aim of these studies was to investigate if nonsurgical transfer techniques or donkey embryo quality affect donkey recipient pregnancy failure. in study 1, the impact of transfer technique was investigated by evaluating if cervical catheterization is associated with prostaglandin release and suppression of luteal function and if donkey recipients would become pregnant after nonsurgical transfer of horse embry ... | 2011 | 22056016 |
| My fat ass: a miniature donkey teaches lessons on helping patients fight obesity. | 2011 | 21957814 | |
| meta-Tyrosine in Festuca rubra ssp. commutata (Chewings fescue) is synthesized by hydroxylation of phenylalanine. | m-Tyrosine is a non-protein amino acid that is structurally similar to the common protein amino acids p-tyrosine and phenylalanine. Copious amounts of m-tyrosine can be found in root exudates of the fine fescue cultivar, Festuca rubra L. ssp. commutata (Chewings fescue). The phytotoxicity of m-tyrosine may contribute to the allelopathic potential of F. rubra. m-Tyrosine in Euphorbia myrsinites (donkey-tail spurge), was previously shown to be synthesized via transamination of m-hydroxyphenylpyruv ... | 2011 | 22192329 |
| comparative morphometric and glycohistochemical studies on the epididymal duct in the donkey (equus asinus) and dromedary camel (camelus dromedarius). | the present study was undertaken to compare morphometric and glycohistochemical differences in the epididymal duct of the donkey and the dromedary camel. paraffin-embedded sections from the different regions of the duct (caput, corpus and cauda) of both species were stained conventionally for general histology and histomorphometry and also with fluorescein isothiocyanate (fitc) conjugated lectins for glycohistochemical mapping. morphometric data (means±se) showed that the luminal diameter was wi ... | 2011 | 21906788 |
| Composition of milk from minor dairy animals and buffalo breeds: a biodiversity perspective. | A comprehensive review is presented of the nutrient composition for buffalo, mare, and dromedary camel milks at the level of breed, and species-level data for yak, mithun, musk ox, donkey, Bactrian camel, llama, alpaca, reindeer and moose milks. Average values of nutrients were calculated and compared. Interspecies values (g 100 g(-1) ) were 0.7-16.1 for total fat, 1.6-10.5 for protein, 2.6-6.6 for lactose, and 67.9-90.8 for water. Reindeer and moose milks had the highest fat and protein concent ... | 2011 | 22083874 |
| disordering of human telomeric g-quadruplex with novel antiproliferative anthrathiophenedione. | linear heteroareneanthracenediones have been shown to interfere with dna functions, thereby causing death of human tumor cells and their drug resistant counterparts. here we report the interaction of our novel antiproliferative agent 4,11-bis[(2-{[acetimido]amino}ethyl)amino]anthra[2,3-b]thiophene-5,10-dione with telomeric dna structures studied by isothermal titration calorimetry, circular dichroism and uv absorption spectroscopy. new compound demonstrated a high affinity (k(ass)∼10⁶ m⁻¹) for h ... | 2011 | 22102877 |
| molecular detection of bartonella species in ticks from peru. | a total of 103 ticks, collected from canines, horses, donkeys, and snakes from peru, were screened for the presence of bartonella dna by polymerase chain reaction analysis. bartonella dna was detected in two ticks using bartonella 16s-23s intergenic spacer region primers and in an additional two ticks using bartonella nadh dehydrogenase gamma subunit gene (nuog) primers. bartonella rochalimae eremeeva et al., b. quintana schmincke, and b. elizabethae daly et al. dna was detected in a rhipicephal ... | 2011 | 22238888 |
| prevalence of hydatidosis in donkeys from central jordan. | one hundred and twenty-two donkeys from central jordan were necropsied during the months of june, july and august 1985 and 21 (17.2%) showed evidence of hydatidosis. no donkeys less than 3 years of age were infected, whereas 36.8% (21/57) aged greater than or equal to 3 years were infected. among the infected donkeys 57.1% (12/21) were hepatic infections, 33.3% (7/21) were hepatopulmonary and 9.5% were pulmonary. fertile cysts were observed in 47.6% (10/21) of cases. the majority of cysts observ ... | 2011 | 3245105 |
| immunotherapy for alzheimer's disease. | in the year 1999, a vaccine approach was found to reduce amyloid deposits in transgenic mice overproducing the amyloid precursor protein. this was followed closely by demonstrations that vaccines or passive immunotherapy could rescue memory deficits in these mice. initial human clinical trials revealed apparent autoimmune reactions in a subset of patients, but also some cases of cognitive benefit and amyloid clearance. further work with passive immunotherapy in mouse models confirmed exceptional ... | 2011 | 21158978 |
| authentication of the 31 species of toxic and potent chinese materia medica by microscopic technique assisted by icp-ms analysis, part 4: four kinds of toxic and potent mineral arsenical cmms. | toxic and potent chinese materia medica (t/pcmm) is a special and very important category of chinese medicines. they have long been used in traditional medical practice and are being used more and more widely throughout the world in recent years. as there may be many fatal toxic effects caused by misusing or confusion of t/pcmm, their quality and safety control arouse increasing attention internationally. researches on the accurate identification to ensure the safe use of t/pcmm are acquired; ho ... | 2011 | 21181703 |
| a randomized triple blind trial to assess the effect of an anthelmintic programme for working equids in morocco. | gastro-intestinal parasitism has been identified as a significant cause of disease in working equids in many countries. this randomized triple-blind trial was designed to assess the impact of an anthelmintic treatment programme (using oral ivermectin and fenbendazole) comparing treated and placebo control populations of working donkeys, mules and horses in field conditions in morocco. in particular, we assessed animal body weight and condition score, together with a questionnaire-based owner eva ... | 2011 | 21208398 |
| kinetics and solvent-dependent thermodynamics of water capture by a fullerene-based hydrophobic nanocavity. | kinetic and thermodynamic properties of water encapsulation from organic solution by an open-cage [60]fullerene derivative have been investigated. 2d exchange nmr spectroscopy (exsy) measurements were employed to determine the association and dissociation constants at 300-330 k (k(a) = 4.3 m(-1) × s(-1) and k(d) = 0.42 s(-1) at 300 k) in 1,1,2,2-tetrachloroethane-d(2) as well as the activation energies (e(a,ass) = 27 kj mol(-1), e(a,diss) = 50 kj mol(-1)). the equilibrium constants and thermodyn ... | 2011 | 21214281 |
| efficacy of eprinomectin pour-on against dictyocaulus arnfieldi infection in donkeys (equus asinus). | a trial to assess the efficacy of eprinomectin (epm) against the lungworm dictyocaulus arnfieldi was carried out on 15, naturally-infected donkeys. ten animals were treated with a 'pour-on' epm preparation (at a dose of 0.5mg/kg bodyweight), and five animals acted as controls. faecal larval counts were carried out two days before treatment, on day of treatment and 7, 14, 21 and 28days post-treatment with the anthelmintic. epm was 100% effective in eliminating faecal larvae from day 7, until the ... | 2011 | 21216164 |
| on the in vivo early toxic properties of a-beta 25-35 peptide in the rat hippocampus: involvement of the receptor-for-advanced glycation-end-products and changes in gene expression. | amyloid-beta peptide (aβ) deposition is assumed to play a pathogenic role in the brain of alzheimer's disease patients. to date, the precise mechanisms underlying aβ toxicity are not fully understood. a recent hypothesis suggesting that the receptor-for-advanced-glycation-end-products (rage)-a trans-membrane protein signaling for oxidative stress-is involved in aβ toxicity is gaining attention. early aβ toxicity could indeed help to explain the deleterious events further produced by this molecul ... | 2011 | 21216281 |
| evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (rbc) additive solutions on in vitro rbc measures. | whole blood (wb) can be held at room temperature (18-25°c) up to 8 hours after collection; thereafter the unit must be refrigerated, rendering it unsuitable for platelet (plt) production. overnight hold at room temperature before processing has logistic advantages, and we evaluated this process in an international multicenter study for both buffy coat (bc)- and plt-rich plasma (prp)-based blood components and compared three red blood cell (rbc) additive solutions (ass) for their ability to offse ... | 2011 | 21223291 |
| assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach. | sugammadex is a γ-cyclodextrin that binds with high affinity to the neuromuscular blocking agents (nmbas) rocuronium (bromide) and vecuronium (bromide) by encapsulation. cyclodextrins are known to form inclusion complexes with other compounds. | 2011 | 21067251 |
| extended phylogeny of the equine arteritis virus sequences including south american sequences. | to perform genetic analysis of the orf5 of equine arteritis virus (eav) may provide new insights into the genetic evolution and origin of the argentinean eav sequences. | 2011 | 20689314 |
| haemosiderin deposition in donkey (equusasinus) liver: comparison of liver histopathology with liver iron content. | histopathological examination was carried out on post mortem samples of liver from 12 donkeys (equus asinus), aged 21-57 years (4 females, 1 stallion, 7 geldings). variable amounts of haemosiderin were present in kupffer cells, portal macrophages and hepatocytes in all cases. in all cases there was infiltration of connective tissue around portal tracts by variable numbers of inflammatory cells (lymphocytes, plasma cells and macrophages) but obvious portal fibrosis was present in only four animal ... | 2011 | 20656308 |
| ancient dna from nubian and somali wild ass provides insights into donkey ancestry and domestication. | genetic data from extant donkeys (equus asinus) have revealed two distinct mitochondrial dna haplogroups, suggestive of two separate domestication events in northeast africa about 5000 years ago. without distinct phylogeographic structure in domestic donkey haplogroups and with little information on the genetic makeup of the ancestral african wild ass, however, it has been difficult to identify wild ancestors and geographical origins for the domestic mitochondrial clades. our analysis of ancient ... | 2011 | 20667880 |
| overlapping juvenile idiopathic arthritis and systemic lupus erythematosus: a case report. | hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. rheumatoid factor was positive, and juvenile idiopathic arthritis (jia) was diagnosed. after a poor response to dmards, an anti-tnf agent (infliximab) was initiated, but to be discontinued due to an allergic reaction. the same complication was observed with the fully human derivative, adalimumab. at the age of 22, the patient presented septicemia with severe anemia and subsequent ... | 2011 | 20676642 |
| equine hyperlipidemias. | hyperlipidemia is the presence of elevated lipid concentrations in the blood and is associated with periods of negative energy balance and physiologic stress. in increased concentrations, circulating lipids typically occur in the triglyceride form, which may interfere with numerous normal physiologic functions, particularly by reducing insulin sensitivity. although the hyperlipidemia risk is greatest in ponies, miniature horses, and donkeys, all equids are at risk if they are in a situation invo ... | 2011 | 21392654 |