Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| listeria antigen-binding cells in the spleens of normal and immunized mice resistant or susceptible to listeriosis. | normal mice of the listeria-resistant c57bl/6 strain contain in their spleens a higher number of cells that bind listeria monocytogenes cell wall fraction antigen (lma) than normal dba/2 mice, which are more susceptible to infection. lma-binding cells are probably b cells, nylon-wool adherent, and inhibited by anti-mouse immunoglobulin antibody but not sensitive to the action of monoclonal anti-mouse macrophage and anti-thy.1.2 antibody. a single intraperitoneal injection of 10(8) listeria monoc ... | 1985 | 3932195 |
| suppression of immune response to listeria monocytogenes: mechanism(s) of immune complex suppression. | we have investigated possible mechanisms underlying immune complex suppression of resistance to listeria monocytogenes. inhibition of resistance was found when immune complexes were formed in vivo in immune mice or in nonimmune mice adoptively transferred with specific antibody. suppression was also found when nonimmune mice were injected with immune complexes preformed in vitro. we investigated the role of complement by decomplementing mice with cobra venom factor purified by high-pressure liqu ... | 1985 | 3932204 |
| phagocytes from flora-defined and germfree athymic nude mice do not demonstrate enhanced antibacterial activity. | in this study we directly compared the in vitro antibacterial activities of resident and inflammatory phagocytes obtained from athymic (nu/nu) and euthymic (nu/+) mice. resident peritoneal macrophages obtained from flora-defined nu/nu and nu/+ mice both demonstrated little ability to restrict the growth of listeria monocytogenes in vitro. inflammatory peritoneal neutrophils and macrophages obtained from flora-defined nu/nu and nu/+ mice did not differ in their ability to kill l. monocytogenes in ... | 1985 | 3932209 |
| protection against facultative intracellular bacteria--role of macrophage activation and granuloma formation. | 1985 | 3932217 | |
| activity of cefotaxime and ceftriaxone alone and in combination with penicillin, ampicillin and piperacillin against neonatal meningitis pathogens. | the activities of penicillin g, ampicillin, piperacillin, cefotaxime and ceftriaxone alone and in combination against 130 isolates of escherichia coli, group b streptococci and listeria monocytogenes from neonatal meningitis were assessed by using agar dilution, checkerboard and time-kill techniques. cefotaxime and ceftriaxone were highly active against e. coli and group b streptococci (mic90 0.05-0.1 mg/1) but not active against list. monocytogenes. penicillin g was more active than ampicillin ... | 1985 | 3932295 |
| therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon. | by exposing human blood-derived macrophages and alveolar macrophages in vitro to dexamethasone, we showed in these studies that glucocorticoids markedly suppress the antimicrobial activity of macrophages but not macrophage activation by lymphokines. as little as 2.5 x 10(-8) mol/liter of dexamethasone prevented macrophages from inhibiting germination of aspergillus spores or from eliminating ingested bacteria such as listeria, nocardia, or salmonella. damage to macrophage function was inhibited ... | 1985 | 3932471 |
| requirement of endogenous interferon-gamma production for resolution of listeria monocytogenes infection. | peritoneal exudate cells and splenic cells of mice infected with listeria monocytogenes show increased production of interferon-gamma (ifn-gamma) after antigen or mitogen stimulation. when an ifn-gamma-specific enzyme-linked immunosorbent assay was used, increased production was first observed 2 days after infection in peritoneal cells and 4 to 6 days after infection in splenic cells. the increased production of ifn-gamma correlated with the clearance of listeria from the peritoneal cavity and s ... | 1985 | 3933006 |
| intra-cellular and extra-cellular growth of l. monocytogenes in chick embryo fibroblast cell culture. | the growth of l. monocytogenes in isolated chick embryo fibroblast cell culture was studied. hanks balanced salt solution and eagles minimal essential medium were shown to support a limited growth of l. monocytogenes. extra-cellular growth on the maintenance medium occurs for 48 h prior to the establishment of intra-cellular organisms. as the uptake of the parasite by the cell culture takes place, intra-cellular replication begins with subsequent release of the organisms into the surrounding med ... | 1985 | 3933211 |
| dissociation between cell-mediated immunity and acquired resistance in systemic murine candidiasis. | mice immunized with 10(7) heat-killed (hk) candida albicans injected subcutaneously with or without bcg, used as an immunoadjuvant, were able to develop strong significant delayed-type hypersensitivity (dth) against c. albicans but without any increase in specific resistance, as measured by median survival time and enumeration of yeasts inside target organ such as lungs, liver, spleen and kidneys after an intravenous (i. v.) challenge of 1 x 10(6) live c. albicans. concomitant activation of the ... | 1985 | 3933406 |
| the effect of phospholipids from listeria monocytogenes and aspergillus fumigatus on degradation of bacterial antigens by mouse peritoneal macrophages. | investigations were carried out on an influence of phospholipids from l. monocytogenes and a. fumigatus on the degradation of streptococcus faecalis cell walls by mouse peritoneal macrophages. it has been found, that macrophages from mice stimulated with phospholipids under studies degraded streptococcal cell walls labeled with dl-alanine-i-14c more efficiently than normal macrophages. activated macrophages degraded also more rapidly antigenic structures of bacterial cell walls reacting with spe ... | 1985 | 3933450 |
| intra-ocular and cns listeriosis following systemic infection in wistar rats with chronic serum sickness. | the relationship of immune complex deposits and cell-mediated immunity to the occurrence of ocular and brain listeriosis following a low (0.007-0.03 ld50) intraperitoneal challenge was investigated in 68 wistar rats with chronic experimental serum sickness and 68 normally resistant controls. the induction of chronic serum sickness involved long continued immunization with bovine serum albumin which resulted in a high level of immune complex entrapment in both the ciliary processes (92%) and chor ... | 1985 | 3933993 |
| induction of alpha/beta interferon and gamma interferon in mice infected with listeria monocytogenes during pregnancy. | alpha/beta interferon (ifn-alpha/beta) was induced in the bloodstream of mice 48 h after intravenous infection with listeria monocytogenes, whereas ifn-gamma was induced in the bloodstream 6 h after stimulation with specific antigen on day 5 of infection in virgin mice. in contrast, no ifn-alpha/beta or ifn-gamma was produced in the bloodstream of pregnant mice after l. monocytogenes infection. however, unusual acid-labile ifn-alpha/beta instead of ifn-gamma was produced in some of the pregnant ... | 1985 | 3934081 |
| relationship of macrophage ia and membrane il 1 expression to antigen presentation. | 1985 | 3934262 | |
| immune complex effects on murine macrophages. i. immune complexes suppress interferon-gamma induction of ia expression. | we have studied the effects of immune complexes on the expression of macrophage surface proteins in vitro. increased expression of the h-2 molecules i-a, i-e, and k on the macrophage membrane was induced by in vitro culture with crude lymphokine or interferon-gamma. expression of all three of the molecules was additionally increased by stimulating the cultures with heat-killed listeria monocytogenes. addition of soluble immune complexes to the cultures did not have any effect on macrophage expre ... | 1985 | 3934266 |
| protective effect of lipoteichoic acid from lactobacillus casei and lactobacillus fermentum against pseudomonas aeruginosa in mice. | lipoteichoic acid (lta) from lactobacillus casei yit 9018 or lactobacillus fermentum yit 0159 augmented the resistance of c57bl/6 mice to infection with pseudomonas aeruginosa, but conferred no resistance to listeria monocytogenes. it is suggested that lta was unable to activate macrophages. | 1985 | 3934337 |
| enzyme release of antigen from streptococcus faecalis and listeria monocytogenes cross-reactive with lancefield group g typing reagents. | enzyme extraction methods are commonly used to release antigen for lancefield serogrouping of streptococci. recently, up to 47% of enterococci have been found to possess antigens cross-reactive with both the group d and the group g grouping reagents. we investigated whether the organisms had recently emerged or whether changes in extraction methods (enzyme extraction) have resulted in our awareness of their existence. we found that approximately 20% of our enterococcal isolates released material ... | 1985 | 3935666 |
| [biochemical characterization of species in the genus listeria]. | seventy listeria strains, including l. monocytogenes (30 strains), l. ivanovii (9), l. innocua (11), l. welshimeri (6), l. seeligeri (10), l. grayi (2) and l. murrayi (2) were subjected to biochemical characterization. the biochemical tests selected comprised: api 50ch, api 20e and api zym strips, hydrolysis of dna and tween 20, 40, 60, 80, egg yolk agar reaction, growth in the presence of 7,5 and 10% nacl, growth at 42 degrees c and 45 degrees c, and susceptibility to antibiotics and trypaflavi ... | 1985 | 3936309 |
| effects of cyclosporin a on experimental infection with listeria monocytogenes. | the effects of cyclosporin a on primary and secondary infection of mice with listeria monocytogenes was studied both at the microbiological and the histomorphological level. this drug, when given in a dose of 100 mg/kg/day, was found to inhibit the development of protective immunity after primary infection as well as the expression of acquired immunity to challenge infection as determined by counting of bacterial numbers in the spleen. the manifestation of delayed type hypersensitivity was also ... | 1985 | 3936654 |
| sequential production of alpha and beta interferons and gamma interferon in the circulation of listeria monocytogenes-infected mice after stimulation with bacterial lipopolysaccharide. | sequential production of interferon (ifn)-alpha/beta and ifn-gamma in the circulation of mice which had been previously infected with viable listeria monocytogenes was induced by injection of lipopolysaccharide (lps) derived from salmonella typhimurium. ifn-alpha/beta production occurred 2 hr after injection of lps, thereafter ifn-gamma appeared and the maximum titer was demonstrated at 6 hr. at that time, almost all of the ifn was ifn-gamma. ifn-gamma production in response to lps was observed ... | 1985 | 3937032 |
| wild birds and silage as reservoirs of listeria in the agricultural environment. | a method for the isolation of listeria which enabled a more rapid detection of the organism was used to examine samples of silage and bird faeces. faecal samples indicated that seagulls feeding at sewage works had a higher rate of carriage than those elsewhere. faecal samples from rooks generally suggested a low incidence of listeria except on one occasion when eight of twenty samples contained listeria monocytogenes: this coincided with the nesting season and the peak period for listeriosis in ... | 1985 | 3938452 |
| [intraocular listeriosis]. | listeria monocytogenes endophthalmitis is an uncommon localization. its evolution is usually complicated by disabling functional visual loss. we report a case occurring in a peculiar epidemiological context. early diagnosis by paracentesis allowed consequent antibiotic therapy. the evolution has been dramatically favorable. early treatment allowed an excellent functional recovery when compared to the reported cases of the literature. | 1985 | 3938786 |
| reverse camp phenomenon of gardnerella vaginalis (a note). | gardnerella vaginalis strains inhibit the haemolysis by listeria monocytogenes on human blood agar incubated in 5-10% co2 atmosphere or under anaerobic conditions. | 1985 | 3939073 |
| some aspects of murine experimental listeriosis. | 1985 | 3939176 | |
| [hemolysins of listeria monocytogenes demonstrable by activation with 2-mercaptoethanol]. | jones and seeliger with the endorsement of the international committee on systematic bacteriology, subcommittee on the taxonomy of listeria, are considering to replace l. monocytogenes atcc 15313 as prototype strain of species because of the lack of hemolytic activity in conventional agar blood media. we demonstrate in this work that atcc 15313 strain is able to induce hemolysis in conventional media under microaerophilic conditions and also has a definite hemolytic activity when supernatants of ... | 1985 | 3939691 |
| the relative importance of other infections. bacterial infections. | 1985 | 3939699 | |
| effects of n-nitrosodimethylamine on cell-mediated immunity. | dimethylnitrosamine (dmn) exposure altered the cell-mediated immune response of b6c3f1 adult female mice as assessed by several immunological assays. following 14 daily exposures (i.p.) to 1.5, 3.0, or 5.0 mg dmn/kg, mice exhibited a depression in their lymphoproliferative response to the t-cell mitogens concanavalin a and phytohemagglutinin, and in their mixed lymphocyte response to mitomycin-treated dba-2 spleen cells. the delayed hypersensitivity response (dhr) to keyhole limpet hemocyanin (k ... | 1985 | 3156199 |
| involvement of suppressor cells induced with membrane fractions of trypanosomes in immunosuppression of trypanosomiasis. | we showed that infection with trypanosoma congolense in mice led to suppression of listeria-induced delayed type hypersensitivity (dth). mice were pre-treated with irradiated t. evansi, which caused rapid and effective suppression of dth. a membrane fraction obtained by homogenizing t. evansi variant in a hypotonic buffer solution and centrifuging it at 150,000g produced suppression of listeria-induced dth when injected i.p. into mice as early as 1 day before listeria immunization. furthermore, ... | 1985 | 3158865 |
| influence of hydroxyethyl starch on humoral and cell-mediated immune responses in mice. | the immunotoxicity of hydroxyethyl starch (hes), a reagent used in leukocytapheresis or as a plasma expander, was assessed. hes did not significantly alter host resistance to listeria monocytogenes or streptococcus pneumoniae. hes (4-32 ml/kg), as well as a physiological saline solution (32 ml/kg), did inhibit the in vitro lymphoproliferation of spleen cells from mice intravenously injected 1 hour prior to removal of the spleens; the proliferation induced by a t-cell and b-cell mitogen was suppr ... | 1985 | 2408361 |
| modifications of host defence mechanisms by an acute non-immunological inflammatory reaction. | mice developing an acute non-immunological inflammatory reaction were examined for modification of specific and non-specific defence mechanisms on the basis of previous observations that these animals displayed an increased resistance to bacterial and parasitic infections but an impaired resistance to neoplasia. local acute inflammation was induced by injection into the pleural cavity of a non-antigenic, endotoxin-free irritant--calcium pyrophosphate microcrystals or low-molecular-weight dextran ... | 1985 | 2408650 |
| killed listeria-induced suppressor t cells involved in suppression of delayed-type hypersensitivity and protection against listeria infection. | pretreatment of mice by intravenous injection with killed listeria provided neither delayed-type hypersensitivity to listeria protoplasm nor protection against listeria infection. assuming that this suppression is due to suppressor cells, we attempted to clarify their induction and characterization. pretreatment with killed bcg instead of killed listeria suppressed the induction of dth and protection in subsequent listeria-immunized mice. conversely, pretreatment with killed listeria suppressed ... | 1985 | 2410356 |
| increased local complement levels upon intraperitoneal injection of mice with listeria monocytogenes and regulation by polyanions. | alternative complement pathway activity in mouse peritoneal fluid was determined by a sensitive microtiter assay with rabbit erythrocytes as target cells and cobra venom factor as the inducer of bystander hemolysis. the intra- and interstrain variations in five mouse strains were 30% and, maximally, 64%, respectively. no activity was detected in genetically c5-deficient mice. in c5-sufficient mice, intraperitoneal injection of heat-inactivated listeria monocytogenes resulted in a 250% increase i ... | 1985 | 2411663 |
| rnase-sensitive and rnase-insensitive protective components isolated from listeria monocytogenes. | crude ribosomes were isolated from listeria monocytogenes serotype 4b and separated into two fractions by molecular sieve chromatography. chemical analysis indicated that fraction i contained cell envelope components while fraction ii contained the ribosomes. both fractions protected mice against listeria, but only in combination with the adjuvant dimethyldioctadecylammonium bromide (dda). rnase-treatment, but not proteinase k-treatment destroyed the protective properties of fraction ii, and rna ... | 1985 | 2412492 |
| antigen recognition by effector t cells in antileishmanial defense. | we have observed that t cells (ly1+2-) from draining lymph nodes of mice that have footpad infections with leishmania major activate macrophages for antileishmanial effects in vitro in an apparently contact-dependent, noncytotoxic manner. the nature of antigenic specificity in this system was investigated. whereas lymphocytes sensitized to l. major induced antileishmanial effects in macrophages infected with l. major, lymphocytes sensitized to listeria monocytogenes were ineffective. when macrop ... | 1985 | 2413143 |
| t cell clones and their products: experimental clues for the immunoprophylaxis and immunotherapy of intracellular bacterial infections? | in this paper experimental models utilizing murine t cell clones specific for the intracellular bacterium listeria monocytogenes are described and some matters of possible relevance to the development of novel immunological strategies against intracellular bacterial infections discussed. improved vaccines against intracellular bacteria should be selected for their expression of a maximum amount of immunoprotective epitopes and their lack of immunosuppressive epitopes. analysis of these epitopes ... | 1985 | 2414224 |
| antibacterial resistance, macrophage influx, and activation induced by bacterial rrna with dimethyldioctadecylammonium bromide. | intraperitoneally injected rrna from pseudomonas aeruginosa combined with dimethyldioctadecylammonium bromide (dda) increased nonspecifically the resistance of mice against an intraperitoneal challenge with extracellular (p. aeruginosa, escherichia coli) and intracellular (listeria monocytogenes) bacteria. this study concerns the mechanism underlying the nonspecific resistance. rna with dda (rna-dda) induced a cell influx and activated peritoneal macrophages (m phi) as judged by the decreased 5' ... | 1985 | 2415454 |
| listeriosis. | 1985 | 2863612 | |
| modulation of the immune response to listeria monocytogenes by benzene inhalation. | benzene is a potent bone marrow toxicant. while all blood cell types are targets for benzene poisoning, lymphocytes are particularly sensitive. the immunotoxic consequences of benzene or its metabolites have been demonstrated in a number of in vitro studies; however, little data exist regarding the effects of benzene on host resistance to infectious agents. this investigation examined the effects of benzene on murine resistance to an infectious agent, listeria monocytogenes. four concentrations ... | 1985 | 2863880 |
| [the saprophytic phase in the ecology of the causative agents of infectious diseases]. | 1985 | 2863907 | |
| migration of natural suppressor cells from bone marrow to peritoneal cavity by live bcg. | delayed-type hypersensitivity (dth) responses were suppressed in mice inoculated with bone marrow cells from mice that had been injected with 10(8) colony-forming units (cfu) of live bcg. upon analysis of this dth-suppression by the use of a macrophage migration inhibition (mi) assay, the in vitro correlate of dth, suppressor macrophages in the peritoneal cavity were found to play an important role in dth suppression. however, neither suppression of dth nor production of suppressor macrophages w ... | 1985 | 2933452 |
| induction by immunomodulatory agents of a macrophage antigen recognized by monoclonal antibody 158.2 and correlation with macrophage function. | ma158.2, a rat monoclonal antibody with binding specificity for cells of the monocyte-macrophage lineage, reacts with an antigen (158.2) whose expression is enhanced on mononuclear cells activated to the tumoricidal phenotype by treatment with lymphokine supernatant containing macrophage activating factor (maf). the functional relevance of enhanced expression of this antigen has been examined in mouse peritoneal macrophages treated with a variety of immunomodulatory agents and assayed for augmen ... | 1985 | 3013425 |
| generation of oxygen species and virulence of listeria monocytogenes. | listeria monocytogenes strains differing in virulence were examined for production of oxygen species. virulent strains a4413 and jh-h exhibited maximal generation of hydrogen peroxide and superoxide, whereas the avirulent strain 9037-7r was least active. the virulence was confirmed by the in vitro assessment of the intracellular fate of the microorganisms in resident macrophages. | 1985 | 2982741 |
| listeria monocytogenes sepsis and small cell carcinoma of the rectum: an unusual presentation of the acquired immunodeficiency syndrome. | a 26-year-old male homosexual initially presented with listeria monocytogenes sepsis and a small cell carcinoma of the rectum. his subsequent course included esophageal candidiasis, pneumocystis carinii pneumonia, and severe t-lymphocyte abnormalities on immunologic testing, consistent with the acquired immunodeficiency syndrome (aids). this represents the first case of aids associated with this unusual tumor and listeria infection. | 1985 | 2983527 |
| [isolation of unbalanced growth forms from listeria and their ultrastructure]. | as the result of the action of penicillin, licl and uv irradiation on listeria culture in the logarithmic phase, unbalanced growth forms (ugf) were obtained. their viability was determined by the number of colony-forming units per ml. in this investigation the action of the above factors in a single cultivation and in consecutive subcultures was studied. viable ugf were obtained under the action of all the above factors. ugf obtained under the action of penicillin were found to convert easily in ... | 1985 | 2986393 |
| are inflammatory phagocytes responsible for resistance to facultative intracellular bacteria? | at least 38 deaths from listeriosis in the united states in recent months have drawn attention to how little we know about resistance to facultative intracellular bacteria. much more is known about resistance to obligate intracellular parasites. macrophages, activated by t cell-derived macrophage activating factors (maf), are able to kill obligate intracellular parasites and tumor cells(1-10) including leishmania, certain trypanosomes, toxoplasma, the obligate intracellular bacterium rickettsia, ... | 1986 | 25289573 |
| opsonic receptor function is reduced on the surface of newborn alveolar macrophages. | neonates have an increased susceptibility to infections. because optimal phagocytosis of offending organisms by alveolar macrophages (am) requires recognition and attachment of opsonized organisms to the am cell membrane, the expression of opsonic receptors on the surface of newborn and adult rat am was investigated using immunologic techniques, cell culture, and flow cytometry. we investigated the expression of fc, c3b, fibronectin, and lectin receptors on newborn (1 to 5 wk) am and compared th ... | 1986 | 3004272 |
| transposon mutagenesis as a tool to study the role of hemolysin in the virulence of listeria monocytogenes. | the role of hemolysin in the virulence of listeria monocytogenes was studied by using transposon mutagenesis. the 26-kilobase conjugative transposon tn1545, originally found in streptococcus pneumoniae, was transferred to a hemolytic virulent strain of l. monocytogenes. the frequency of transfer was estimated to be about 10(-8) per recipient. this allowed us to isolate a nonhemolytic mutant which most likely harbors a single copy of tn1545. loss of hemolysin production was associated with loss o ... | 1986 | 3007363 |
| enhanced resistance against listeria monocytogenes at an early phase of primary infection in pregnant mice: activation of macrophages during pregnancy. | we investigated the pregnancy-induced changes in macrophage activity which are important in the expression of host defense against infections. several macrophage functions were examined by using listeria monocytogenes. in pregnant mice, prolonged survival and enhanced in vivo elimination of bacteria were observed in the early phase of primary infection. functions of peritoneal macrophages, including in vitro phagocytosis intracellular killing, glucose consumption, generation of superoxide anion, ... | 1986 | 3011673 |
| identity between human interferon-gamma and "macrophage-activating factor" produced by human t lymphocytes. | human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (ifn-gamma) as shown by enhanced killing of listeria monocytogenes and increased production of h2o2 in response to phorbol myristate acetate. half-maximal stimulation for macrophage activation (maf) was observed with 10-20 antiviral u/ml of purified recombinant ifn-gamma. these maf activities were found to correlate with the antiviral activity dependent on ... | 1986 | 3102242 |
| a specific serine proteinase is inducible in lyt-2+,l3t4- and lyt-2-,l3t4+ t cells in vitro but is mainly associated with lyt-2+,l3t4- effector cells in vivo. | recently, we and others reported on the expression of a serine proteinase in long-term cultured murine t lymphocyte cell lines. in an attempt to explore the distribution and possible regulation of this enzyme in t lymphocyte subsets, we performed the presented detailed study. we found that the proteinase is not expressed by thymocytes and resting t cells but can be induced by lectin or antigen in combination with lymphokine sources in vitro in macrophage-depleted unselected t cells as well as in ... | 1986 | 3102247 |
| depression of delayed-type hypersensitivity in mice with hypothalamic lesion induced by monosodium glutamate: involvement of neuroendocrine system in immunomodulation. | delayed-type hypersensitivity (dth) was depressed in mice that had been treated with monosodium glutamate (msg) in their suckling period. analysis of the dth depression by use of the macrophage migration inhibition assay showed dysfunction of dth effector t cells. the neuronal loss of nuclei in the hypothalamus, which elaborates the corticotropin-releasing factor and the hypersecretion of adrenocorticotrophic hormone, was observed in the msg-treated mice. therefore, dth response may be modulated ... | 1986 | 3015779 |
| the role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages. | the in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of listeria monocytogenes egd (listeria) by peritoneal macrophages (pm) was investigated. generation of superoxide anion by pm stimulated with phorbol myristate acetate (pma) was significantly increased by intraperitoneal injection of lactobacillus casei yit 9018 (lc9018) or corynebacterium parvum (cp), but not by injection of peptone. however, superoxide anion generation by lc9018-elicited pm stimulated with li ... | 1986 | 3020680 |
| relation of cytosolic calcium to the microbicidal activation of blood monocytes by recombinant gamma interferon. | oxygen metabolism and calcium ion (ca++) handling in blood monocytes were greatly affected by treatment with recombinant gamma interferon (rifn-gamma). incubating the monocytes with rifn-gamma resulted in increased basal production of superoxide anion, as well as a significantly enhanced respiratory burst in response to concanavalin a (con a). a concomitant increase in microbicidal activity against listeria monocytogenes was observed, and cell membrane permeability to ca++ was enhanced by treatm ... | 1986 | 3021865 |
| in vitro and in vivo activity of ly 146032, a new cyclic lipopeptide antibiotic. | the in vitro activity of ly 146032, a cyclic lipopeptide antibiotic belonging to the class of agents designated a21978c, was compared with those of vancomycin, cefpirome, cefotaxime, and clindamycin against selected gram-positive bacteria. the new drug inhibited all staphylococcal isolates, including methicillin-resistant strains, at concentrations of less than or equal to 1.0 microgram/ml. the activity of ly 146032 was comparable to that of vancomycin against most streptococci, but the latter d ... | 1986 | 3024560 |
| improved listeria monocytogenes selective agar. | by increasing the licl concentration to 5 g/liter and adding 20 mg of moxalactam per liter to modified mcbride agar base, it was possible to inhibit the growth of many bacteria which interfered with the recovery of listeria monocytogenes from beef. | 1986 | 3024563 |
| silica decreases phagocytosis and bactericidal activity of both macrophages and neutrophils in vitro. | silica, or silicon dioxide, has been shown to be toxic for macrophages. this is probably because it damages phagolysosomal membranes, allowing lysosomal enzymes to disrupt the cell. neutrophils also take up particles such as silica and in addition they contain lysosomes. the purpose of this study was to determine whether incubation in vitro with silica inhibits function not only of mouse macrophages, but also of mouse neutrophils. the data show that incubation with silica for 1-3 hr decreases vi ... | 1986 | 3026960 |
| transposable multiple antibiotic resistance in streptococcus pneumoniae. | a mobile genetic element, designated tn1545, was detected in the chromosome of streptococcus pneumoniae bm4200, a clinical isolate multiply resistant to antibiotics. the 25.3 kb element conferred resistance to kanamycin and structurally related aminoglycosides by synthesis of a 3'-aminoglycoside phosphotransferase type iii (apha-3), to macrolide-lincosamide-streptogramin b-type antibiotics (ermam), and to tetracycline (tetm). tn1545 was self-transferable to a recombination deficient s. faecalis ... | 1986 | 3027505 |
| protective effect of nocardia rubra cell wall skeleton on experimental infection in normal and immunosuppressed mice. | the protective effect of nocardia rubra cell wall skeleton (n-cws) on experimental infections was investigated in normal and immunosuppressed mice. pretreatment with n-cws provided protection against acute systemic infections due to pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae, serratia marcescens and listeria monocytogenes in normal mice. n-cws administered before or after challenge also showed protective activity against herpes simplex virus infection in normal mice. n-cws w ... | 1986 | 3028434 |
| inhibitory effect of liposome-encapsulated penicillin g on growth of listeria monocytogenes in mouse macrophages. | administration of penicillin g encapsulated in liposomes inhibited the proliferation of listeria which infected mouse intraperitoneal resident macrophages whereas free penicillin g and/or liposomes did not. this result suggests that administration of antibiotics encapsulated in liposomes is an effective treatment for the intracellular infection. | 1986 | 3103258 |
| [causes of lamb losses with special reference to listeriosis on a large-scale farm]. | epizootiological studies on lamb losses on a large scale farm (4.5 thousand mothers) were carried out. the results of the studies denied the direct effect of maize silage on the genesis of enzootia of listeriosis. the earlier reports were confirmed, i.e. that the direct cause of enzootia of listeriosis is the weakening of an animal organism due to other microbiological, zoohigienical, nutritional factors (e.g. not proper content of mineral compounds). maize silage has a destructive effect on the ... | 1986 | 3111517 |
| immunomodulatory effect of listeria monocytogenes infection. i. allotransplantation reaction in infected mice. | the rejection reaction of skin graft in listeria monocytogenes infected mice was examined in the allogeneic system: recipient balb/c mice (haplotype h-2d) and donor g3h mice (haplotype h-2k). it was observed that this reaction was significantly potentiated when skin allograft was transplanted in the period of the highest monocytosis and the strongest delayed type hypersensitivity to listeria monocytogenes antigen in the infected recipients. this finding suggests that the allotransplantation reac ... | 1986 | 3109348 |
| immunomodulatory effect of listeria monocytogenes infection. ii. natural cell cytotoxicity in infected mice. | the natural cell cytotoxicity of blood leukocytes, splenocytes and peritoneal cells derived from balb/c mice being on day 1, 3, 5, 7, 9 of listeriosis to allogeneic fibroblast l 929 was examined. the intensity of cytotoxic reaction was assessed by the per cent of specific 51cr release from target cells. to check if this reaction correlates with the level of monocyte-macrophage lineage cells present in the effector cells of if it depends on the development of delayed type hypersensitivity to list ... | 1986 | 3109349 |
| listeria meningitis resistant to ampicillin. | 1986 | 3110504 | |
| [obtaining dicloxacillin-resistant mutants in listeria monocytogenes]. | we obtained ten dicloxacillin resistant mutants from listeria monocytogenes atcc: 15313 (29-ccm-a: 454). none of the mutants could be differentiated from the parental strain (except for their increased resistance) neither using conventional biochemical assays nor by analysis of the electrophoretic pattern of their detergent-soluble proteins (figure 1). the wild type strain and some of these mutants were tolerant for dicloxacillin and/or penicillin g, but no rigorous correlation with each decreas ... | 1986 | 3120240 |
| evaluation of anti-listeria monocytogenes antibodies by elisa. | a new elisa test using the purified listeria monocytogenes-derived antigen lm 84 ag is described together with its application in the diagnosis of listeriosis. fifty-seven human sera were titrated by the elisa and the complement fixation method and compared for specificity and sensitivity. the problem of possible cross-reactions with other antigens is discussed. | 1986 | 3135221 |
| [listeria monocytogenes encephalitis without meningitis. value of monitoring by cerebral x-ray computed tomography]. | 1986 | 2935846 | |
| synergy of ciprofloxacin and azlocillin in vitro and in a neutropenic mouse model of infection. | combinations of ciprofloxacin with azlocillin, piperacillin and ticarcillin were tested in vitro against clinical isolates. azlocillin plus ciprofloxacin showed synergy against 30% of pseudomonas aeruginosa isolates; it was either synergistic or additive against 78% of all isolates tested even those resistant to the beta-lactam. synergism was rarely noted for klebsiella pneumoniae, escherichia coli, enterobacter spp. or branhamella spp. isolates. minimum inhibitory concentrations of ciprofloxaci ... | 1986 | 2938945 |
| in-vitro activity of newer quinolones against aerobic bacteria. | nalidixic and five newer 4-quinolones, ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin were tested against 576 recent clinical aerobic bacterial isolates. the 4-quinolones were regularly active (mic90 less than 4 mg/l) against the following bacteria: staphylococcus aureus, s. epidermidis, s. saprophyticus, different enterobacteriaceae, haemophilus influenzae, campylobacter jejuni, pseudomonas aeruginosa, agrobacter spp., aeromonas spp., plesiomonas spp., neisseria meningitidis. ot ... | 1986 | 2940214 |
| why is listeria monocytogenes not a pathogen in the acquired immunodeficiency syndrome? | 1986 | 2940988 | |
| [pregnancy and the status of the fetus and newborn infant of women with a positive complement fixation test with listeria monocytogenes antigen]. | 1986 | 2945480 | |
| [external lumbar drainage in listeria monocytogenes meningitis]. | 1986 | 2950425 | |
| anti-bacterial immunity to listeria monocytogenes in allogeneic bone marrow chimera in mice. | protection and delayed-type hypersensitivity (dth) to the facultative intracellular bacterium listeria monocytogenes (l.m.) were studied in allogeneic and syngeneic bone marrow chimeras. lethally irradiated akr (h-2k) mice were successfully reconstituted with marrow cells from c57bl/10 (b10) (h-2b), b10 h-2-recombinant strains or syngeneic mice. irradiated akr mice reconstituted with marrow cells from h-2-compatible b10.br mice, [br----akr], as well as syngeneic marrow cells, [akr----akr], showe ... | 1986 | 2871109 |
| protection of mice against intestinal amoebiasis with bcg, corynebacterium parvum and listeria monocytogenes. | treatment with corynebacterium parvum or bcg, or infection with live listeria monocytogenes was found to protect mice against subsequent infection with entamoeba histolytica. complete protection was obtained in mice treated with 10(7) (colony forming units) of bcg but not with 10(5). partial protection was achieved with 10(6) of bcg. these data provide evidence that non-specific immunity plays an important role in the host defense against amoebic infection. | 1986 | 2880331 |
| antimicrobial activity of various immunomodulators: independence from normal levels of circulating monocytes and natural killer cells. | the effects of 89sr treatment on the natural host resistance of cd-1 mice and the enhancement of resistance by immunomodulators to infection with listeria monocytogenes or herpes simplex virus type 2 (hsv-2) were determined. in the cd-1 mouse, single-dose treatment with 89sr caused a profound decrease in the number of circulating monocytes (mo), lymphocytes, and polymorphonuclear leukocytes (pmn) within 1 week. there was also marked functional impairment of the mo inflammatory response, as well ... | 1986 | 2416693 |
| production of listeriolysin by beta-hemolytic strains of listeria monocytogenes. | listeriolysin was isolated from target rabbit erythrocyte membranes after lysis of the cells with partially purified toxin derived from a culture supernatant of listeria ivanovii. the membrane form of the toxin exhibited properties similar to those previously found for streptolysin o. detergent-solubilized, delipidated listeriolysin was found to comprise a heterogeneous population of partially and fully circularized, amphiphilic oligomers whose embedment within the lipid bilayer generated large ... | 1986 | 3079734 |
| differences in initial rate of intracellular killing of salmonella typhimurium by granulocytes of salmonella-susceptible c57bl/10 mice and salmonella-resistant cba mice. | the contribution of granulocytes to differences in the innate susceptibility of mouse strains to infection by salmonella typhimurium was assessed on the basis of the size and composition of the inflammatory exudate after i.p. injection of bacteria and the intracellular killing of the bacteria by exudate peritoneal cells and blood granulocytes of resistant cba and susceptible c57bl/10 mice. the increase in the numbers of both peritoneal granulocytes and macrophages 24 hr after i.p. injection of v ... | 1986 | 3079795 |
| [listeria sepsis in aids]. | 1986 | 3081316 | |
| isolation of listeria monocytogenes from an eastern wild turkey. | 1986 | 3081738 | |
| [acute purulent listeria seelingeri meningitis in an immunocompetent adult]. | within the genus listeria, the species l. monocytogenes most frequently causes disease in animals and humans. l. seeligeri, a species recently described, has been considered experimentally nonpathogenic so far. the authors report the first case of human infection in a previously healthy adult presenting with acute purulent meningitis due to l. seeligeri. the patient recovered promptly after a course of ampicillin and gentamicin, but developed severe neurological sequelae (epilepsy, hydrocephalus ... | 1986 | 3082004 |
| isolation of listeria monocytogenes from raw milk. | during a recent outbreak of listeriosis, we examined 121 raw milk samples and 14 milk socks (filters). listeria monocytogenes was recovered from 15 (12%) of 121 milk specimens and 2 (14%) of 14 milk socks. the optimal processing method consisted of cold enriching diluted milk for 1 month with culture to selective broth, followed by plating. | 1986 | 3082282 |
| monoclonal antibody analysis of listeria monocytogenes-induced cytotoxic lymphocytes. | an immunizing infection with listeria monocytogenes provides a potent stimulus for the formation of prekiller lymphocytes. their cytolytic potential is revealed when the cells are restimulated in vitro by listeria antigens. listeria monocytogenes-induced cytotoxic lymphocytes and the prekiller cells from which they are derived were characterized in respect to their surface antigenic markers. using monoclonal antibodies, b-cell depleted lymphocytes from the thoracic duct of listeria immune rats w ... | 1986 | 3082747 |
| enhancement of hematopoietic response of mice by subcutaneous administration of lactobacillus casei. | mice that had received heat-killed lactobacillus casei (lc 9018) subcutaneously (s.c.) showed enhanced resistance to systemic (i.e., intravenous) infection with listeria monocytogenes, but the antilisterial resistance of mice was less augmented by s.c. administration of propionibacterium acnes ("corynebacterium parvum"). though there was little change in the total number of splenic leukocytes after s.c. administration of lc 9018, the monocyte-macrophage ratio increased after treatment, reaching ... | 1986 | 3082755 |
| enhanced resistance to listeriosis induced in mice by preinoculation treatment with t-2 mycotoxin. | the effect of t-2 toxin on cell-mediated resistance to bacterial infection was evaluated in mice challenge exposed with listeria monocytogenes. mice were treated orally on days -5, -4, -3, -2, -1, +1, and +3 with 2.0, 1.0, 0.5, or 0 mg of t-2 toxin/kg of body weight and were exposed to 10(6) (ld100) or 10(5) (ld50) l monocytogenes by intraperitoneal injection on day 0. necrosis and depletion of lymphocytes in the thymus and spleen, decrease in thymus weight, reductions in the number of circulati ... | 1986 | 3083736 |
| [listeria monocytogenes in pasteurized milk]. | an haemolytic listeria monocytogenes strain pathogenic to mice was isolated from 6 out of 28 (21.4%) pasteurized milk samples (3.2% fat milk treated at 78 degrees c for 15 s) marketed by a madrid processing plant. listeria grayi was recovered from 25 of the samples (89.2%) and l. innocua from 3 samples (10.7%). one milk sample was contaminated with l. welshimeri. no strains of l. ivanovii, l. seeligeri, l. murrayi, or l. denitrificans were isolated. these results show that pathogenic listeria st ... | 1986 | 3084052 |
| isolation and characterization of protective t cells induced by listeria monocytogenes. | rats convalescing from a recent infection with listeria monocytogenes generate t cells which can protect recipient rats against a challenge infection with that organism. using monoclonal antibodies that react with some but not all rat peripheral t cells, the t-cell mediators of acquired resistance to infection (tcri) were isolated by panning and characterized by using a fluorescence-activated cell sorter. many l. monocytogenes-immune tcri were relatively large cells as judged by their light-scat ... | 1986 | 3084382 |
| opsonization of listeria monocytogenes type 4b by human adult and newborn sera. | we studied the requirements for opsonization of listeria monocytogenes type 4b with chemiluminescence and bactericidal assays and electron microscopy. preopsonization with 3% adult serum had good opsonic activity (27,300 +/- 11,000 [standard deviation] counts, chemiluminescence assay), while 3% newborn cord serum was not opsonically active (820 +/- 530 counts, p less than 0.001 versus adult serum). in addition, organisms opsonized with cord serum were not killed (0% bacterial killing) and were l ... | 1986 | 3084384 |
| structural studies on teichoic acids in cell walls of several serotypes of listeria monocytogenes. | structural studies were carried out on the teichoic acids in cell walls of listeria monocytogenes serotypes 3a, 4b, 4f, 6, and 7. the structure of the dephosphorylated repeating units, obtained by treatment with 46% hydrogen fluoride or alkaline hydrolysis, was examined by methylation analysis, acetolysis, and 1h-nmr spectroscopy. the results of smith degradation of the teichoic acids and 13c-nmr spectroscopy led to the following most likely structures of the repeating units of the teichoic acid ... | 1986 | 3084460 |
| isolation of corynebacterium aquaticum from spinal fluid of an infant with meningitis. | a 4-week-old female was hospitalized because of vomiting, irritability, and nuchal rigidity. a spinal fluid culture yielded corynebacterium aquaticum. the diagnosis of c. aquaticum meningitis in this infant was supported by the following cerebrospinal fluid findings: gram stain, elevated protein, hypoglycorrhachia, positive c-reactive protein, and polymorphonuclear leukocytosis. antigen studies for common bacterial causes of meningitis were negative. c. aquaticum is a rare cause of human disease ... | 1986 | 3084551 |
| augmented induction of interferons during listeria monocytogenes infection. | mice infected iv with an immunizing dose of the gram-positive bacterium, listeria monocytogenes, produced circulating interferon (ifn) during the inductive phase of the immune response to listeria. listeria infection also dramatically altered the host's responsiveness to ifn-inducing agents. within 24 hr of infection, mice acquired a 50-fold greater than normal capacity to produce the ifn alpha and/or ifn beta classes (ifn alpha/beta) following iv injection of endotoxin. serum levels of ifn alph ... | 1986 | 3084667 |
| isolation of l monocytogenes from ovine brain. | 1986 | 3085320 | |
| rapid quantitative assessment of the distribution of listeria in silage implicated in a suspected outbreak of listeriosis in calves. | a silage clamp was sampled for the presence of listeria species. even though covered by a heavy duty black plastic sheet the top few centimetres of silage were heavily contaminated with listeria species. in the areas nearest the edges of the sheet the pathogenic species listeria monocytogenes was found in numbers in excess of 12,000 organisms/g silage. using the methods of isolation described, pathogenic species of listeria could be differentiated from non-pathogenic species in three to four day ... | 1986 | 3085322 |
| [bacteriophages and bacteriocins of the genus listeria]. | since the discovery of the first listeria bacteriophage by schultz in 1945, more than 219 phages were isolated for l. monocytogenes, l. invanovii, l. innocua, l. seeligeri and l. welshimeri. to date, no phage for l. murrayi and l. grayi is described in the literature. unless two phages found by jasińska in a water sample, all the other phages, when the origin is mentioned, were isolated from lysogenic strains, with or without induction. electron microscopic examination of 55 listeria phages reve ... | 1986 | 3085381 |
| [bacterial septicemia: an unrecognized complication of hemochromatosis. study of 3 cases and review of the literature]. | 1986 | 3085416 | |
| [pathogenicity of listeria]. | 20 different listeria strains which hitherto have been all classed with the same serovar 3 of l. monocytogenes because of common surface markers, differ markedly in respect to their pathogenic capacities. some strains are virulent, because they are able to multiply within a normal, adult mouse. others show only weak virulence, since they survive within the host for several days. multiplication, however, does not occur. still other strains are rapidly eliminated and thus avirulent. these characte ... | 1986 | 3086212 |
| macrophage ia expression in athymic nude versus neonatally thymectomized mice. | the requirement of the thymus for the production of ia-inducing lymphokine was studied in athymic nude, neonatally thymectomized (ntx), and sham-operated (sham) mice. the peritoneal macrophages from ntx mice immunized with viable listeria monocytogenes 14 days previously contained as high a proportion of ia-bearing macrophages as those from sham mice, while those from athymic nude mice contained only a small proportion. intraperitoneal injection of a culture supernatant derived from immune splee ... | 1986 | 3086214 |
| serum amyloid p-component-induced enhancement of macrophage listericidal activity. | purified serum amyloid p component (sap), the major acute-phase reactant of mice, augmented the in vitro listericidal activity of inflammatory (elicited) macrophages, bone marrow-derived monocytes, and macrophages from a subcutaneous site of inflammation. monocytes and macrophages from c57bl/b6 mice, which are relatively resistant to listeria monocytogenes, exhibited a significantly greater enhanced killing capacity for listeria than macrophages from listeria-susceptible a/j mice. sap did not al ... | 1986 | 3086231 |
| immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in b6c3f1 mice--ii. altered cell-mediated immunity and tumor resistance. | we have previously demonstrated that the polycyclic aromatic hydrocarbons benzo[a]pyrene (b[a]p) and 7,12-dimethylbenz[a]anthracene (dmba) produce a marked decrease in spleen weight, spleen and bone marrow cellularity and the number of igm plaque forming cells generated in response to a t-dependent antigen. exposure to dmba, but not b[a]p, increased susceptibility to challenge with pyb6 tumor cells and listeria monocytogenes suggesting that dmba produces immune impairment involving cell-mediated ... | 1986 | 3086244 |
| detection and enumeration of listeria monocytogenes in a sewage treatment plant in iraq. | listeria monocytogenes was isolated from a sewage treatment plant in baghdad, iraq, at all stages of treatment. the treatment processes did not yield a sewage sludge cake or a final discharge free of listerias. the agricultural practice of using such sewage products as fertilizers could become a route of spreading the organism in iraq, particularly by infecting animals that consume vegetation in fields spread with such sewage. dewatering of sewage reduced the number of l. monocytogenes but long ... | 1986 | 3086271 |
| in vivo and in vitro expression of macrophage membrane interleukin 1 in response to soluble and particulate stimuli. | we examined the expression of a membrane form of interleukin 1 (il 1) by macrophages. murine peritoneal macrophages fixed immediately after harvesting, in suspension, did not show membrane il 1. membrane il 1 was expressed after a 3-hr culture on plastic dishes. these findings allowed us to examine some conditions in vivo that may trigger the expression of this protein; that is, by fixing the macrophages in suspension we could determine if a given stimulus had an effect. we found that membrane i ... | 1986 | 3086442 |
| regulation of macrophage ia expression in mice with severe combined immunodeficiency: induction of ia expression by a t cell-independent mechanism. | we have studied the expression of ia molecules by macrophages from mice with severe combined immunodeficiency (cb-17 scid) that lack demonstrable t cell and b cell functions. cb-17 scid mice had approximately normal numbers of ia-bearing macrophages in the peritoneal cavity, spleen, and liver. peritoneal macrophages responded in culture to t cell-derived lymphokines with enhanced expression of ia molecules. however, unlike immunocompetent controls, scid mice could not enhance ia expression in an ... | 1986 | 3086456 |
| [a case of meningitis infected with listeria monocytogenes type 3b]. | 1986 | 3086601 |