Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| effects of racing and training on serum thyroid hormone concentrations in racing greyhounds. | to determine the effects of racing and training on serum thyroxine (t4), triiodothyronine (t3), and thyroid stimulating hormone (tsh) concentrations in greyhounds. | 2001 | 11763190 |
| [dynamics of spectral characteristics of theta- and alpha-range eeg during negative emotional reactions]. | power characteristics of the eeg theta and alpha rhythms were studied in a human in neutral state and during a conditioned negative emotional reaction (fp1, fp2, f3, f4, c3, c4, p3, p4, o1, o2, f7, f8, t3, t4, t5, and t6 derivations). a significant increase in the relative spectral power in the narrow theta band of 7.4-8.1 hz in the frontocentral and temporal brain regions was observed during the development of the negative emotional reaction. the alpha-rhythm dynamics during the negative reacti ... | 2001 | 11764515 |
| thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dsfunction in apparently healthy subjects. | in order to establish its usefulness for the diagnosis and follow-up of thyroid autoimmune diseases, thyroid ultrasonography together with free t4 (ft4), free t3 (ft3), tsh, antibodies (tg ab) and thyroperoxidase antibodies (tpo ab) were performed and re-evaluated during a 3-yr follow-up in 482 apparently healthy subjects, living in a borderline iodine-sufficient urban area. thyroid dysfunction was found in 7 out of 12 (58.3%) subjects with circulating thyroid autoantibodies, who also had thyroi ... | 2001 | 11765045 |
| blood levels of atrial natriuretic peptide, endothelin, cortisol and acth in patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass. | previous studies demonstrated a biphasic time course with post-operative dissociation of blood levels of cortisol and acth in patients undergoing major surgery and critically ill patients. a possible role of endothelin and atrial natriuretic peptide (anp) in the dissociation of concentrations of cortisol and acth in critically ill patients has been suggested. in the present study, we investigated the perioperative course of blood levels of endothelin, anp, acth, and cortisol in 13 male patients ... | 2001 | 11765047 |
| mammary gland carcinoma-related increase of type i iodothyronine 5'-deiodinase activity in sprague-dawley rats. | type i, iodothyronine 5'-deiodinase (5'-di) catalyses deiodination of the prohormone thyroxine (t4) to the metabolically active 3,5,3'-triiodo-l-thyronine (t3). the present study was undertaken to investigate the activity of 5'-di in rat mammary gland tumours representing various combinations of histologically defined papillary, cribriform or comedo patterns of ductal carcinomas. female sprague-dawley rats were given two doses 50 mg x kg(-1) 1-methyl-1-nitrosourea (mnu) in abdominal parts on the ... | 2001 | 11765219 |
| effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of angora goats. | forty-eight angora goats (24 wethers and 24 doelings; 5 mo old; 16 +/- 0.5 kg initial bw) were used in an experiment with a 2 x 3 factorial treatment arrangement (n = 8) to evaluate effects of recombinant bovine somatotropin (bst) administration and thyroid hormone status (euthyroid, hypothyroid, and hyperthyroid) on hormone levels, adg, and mohair fiber growth. the bst was a slow-release zinc-based suspension, with sustained delivery (100 microg/[kg bw x d]) over a 14-d period. hyperthyroidism ... | 2001 | 11768122 |
| do different aminobisphosphonates have similar preventive effect on experimental thyroid hormone-induced osteopenia in rats? | we compared similar doses of three different aminobisphosphonates (bp): olpadronate (opd), pamidronate (apd), and alendronate (ale) on osteopenia induced by thyroxine (t4)-treatment in ovx and sham adult rats. female sprague dawley rats (259 +/- 8 g) were treated with vehicle (sham+vh and ovx+vh), 250 microg t4/kg/day (sham+t4 and ovx+t4), 0.3 mg opd/kg/day (sham+opd and ovx+opd), 0.2 mg ale/kg/day (sham+ale and ovx+ale), 1.5 mg apd/kg/day (sham+apd and ovx+apd), t4+opd (sham+t4+opd and ovx+t4+o ... | 2001 | 11768202 |
| triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats. | acute effects of triiodothyronine (t3) on postischemic myocardial stunning and intracellular ca2+ contents were studied in the isolated working hearts of streptozotocin-induced diabetic rats and age-matched controls. after two weeks of diabetes, serum t3 and t4 levels were decreased to 62.5% and 33.9% of control values. basal preischemic cardiac performance did not differ between diabetic and control rats. in contrast, during reperfusion after 20-min ischemia, diabetic rats exhibited an impaired ... | 2001 | 11693271 |
| morphological and functional differentiation of human thyroid cells in collagen gel culture. | cultured human thyroid cells in collagen gel culture were examined on cell morphology and the production of thyroglobulin (tg), triiodothyronine (t3) and thyroxine (t4) which are components of functional differentiation. | 2001 | 11694378 |
| unmasking of childhood hypothyroidism by disseminated xanthomas. | secondary hyperlipidemia is a common laboratory finding in children with nephrotic syndrome, diabetes mellitus, and hypothyroidism. however, clinical signs of hyperlipidemia are extremely rare in childhood. we report on an 11-year-old girl who presented with a disseminated yellow papulomatous rash on the lower limbs and yellow skin creases on the palms of her hands. blood tests yielded an opaque serum with a triglyceride concentration of 820 mg/dl and cholesterol of 1050 mg/dl. skin biopsy of on ... | 2001 | 11694680 |
| effects of dioxins and polychlorinated biphenyls (pcbs) on thyroid function in infants born in japan--the second report from research on environmental health. | dioxins (pcdd + pcdf) and polychlorinated biphenyl (pcb) are potentially hazardous compounds and have structural similarity to thyroid hormones. our research group on "dioxins and pcb in human milk" was organized in 1997 and has been active for the past three years. we collected breast milk from 80 mothers living in tokyo, saitama, ishikawa and osaka prefecture in japan at 5, 30, 150, 300 postpartum days and measured pcdds, pcdfs and pcbs during 1998-1999. we added another 20 prefectures and cit ... | 2001 | 11695630 |
| endoscopic t4-sympathetic block by clamping (esb4) in treatment of hyperhidrosis palmaris et axillaris--experiences of 165 cases. | prevention of postoperative complications becomes relatively important when surgical procedures are easy to learn and perform. endoscopic thoracic sympathetic surgery (ets), which is now more accessible to surgeons after the 2nd international symposium of thoracic sympathicotomy, would be the typical examples in surgery. reflex sweating is one of the famous and annoying complications that surgeons endeavor to avoid but in vain in ets. incidentally, we found that preservation of sympathetic tone ... | 2001 | 11695785 |
| efficacy and safety of thoracoscopic sympathicotomy for hyperhidrosis of the upper limb. results of 734 sympathicotomies. | thoracoscopic sympathicotomy (ts) evolved as treatment of choice in severe hyperhidrosis. the aim of this study was to assess the role of video-assistance in ts (vats) versus conventional ts (cts) for primary hyperhidrosis of the upper limb with regard to safety, side-effects and long-term outcome. | 2001 | 11695794 |
| a unique experience with human pre-immune (12 weeks) and hypo-immune (16 weeks) fetal thymus transplant in a vascular subcutaneous axillary fold in patients with advanced cancer: a report of two cases. | the successful development of fetal cell/tissue transplantation in adults has resulted in the possibility of eventual therapeutic solutions with a variety of intractable diseases. umbilical cord whole blood transplantation appears to be safe in the adult system. in severe forms of digeorge syndrome, cultured thymus transplant can help in the reconstitution of the immune condition of the host. successful fetal tissue transplant in adults has raised the hope of future effective gene transplant and ... | 2001 | 11695808 |
| the diagnostic value of bone scan in patients with renal cell carcinoma. | bone scan is performed as part of the evaluation of bone metastasis. we assessed the diagnostic value of bone scan in patients with renal cell carcinoma. | 2001 | 11696720 |
| thyroid hormone-induced oxidative damage on lipids, glutathione and dna in the mouse heart. | oxygen radicals of mitochondrial origin are involved in oxidative damage. in order to analyze the possible relationship between metabolic rate, oxidative stress and oxidative damage, of1 female mice were rendered hyper- and hypothyroid by chronic administration of 0.0012% l-thyroxine (t4) and 0.05% 6-n-propyl-2-thiouracil (ptu), respectively, in their drinking water for 5 weeks. hyperthyroidism significantly increased the sensitivity to lipid peroxidation in the heart, although the endogenous le ... | 2001 | 11697138 |
| thyroid function tests, serum lipids and gender interrelations in a middle-aged population. | to study the value of screening for thyroid function in a screening program for hyperlipidaemia. | 2001 | 11697562 |
| the role of the left temporal region under the cognitive motor demands of shooting in skilled marksmen. | a number of investigators have reported elevated left temporal alpha power in marksmen during response preparation. this finding has been interpreted to indicate the suppression of irrelevant cognitive processes. however, lower-order motor processes have not been excluded as a possible explanation. event-related alpha power (11-13 hz) was examined at sites t3, t4, c3, and c4 in eight skilled marksmen during shooting and two control tasks varying in perceptual-motor complexity. over an 8-s period ... | 2001 | 11698117 |
| [acinic cell carcinomas of the parotid gland. a retrospective analysis]. | acinic cell carcinoma of the parotid gland is a rare malignant tumor, which is generally regarded as low grade. however, rapidly fatal courses do occur. | 2001 | 11699143 |
| abnormal eeg patterns in treatment-resistant schizophrenic patients. | this study was conducted in order to compare the eeg patterns of schizophrenics who do not respond to typical neuroleptics with those who do respond under typical neuroleptic medication and a group of controls. absolute (ap) and relative power (rp), and inter- and intrahemispheric correlations were calculated. nonresistant schizophrenics showed lower delta rp, higher alpha 1 ap and rp and higher correlation between prefrontal areas than the resistant ones and controls. resistant schizophrenics s ... | 2001 | 11699340 |
| extreme thyroid hormone resistance in a patient with a novel truncated tr mutant. | resistance to thyroid hormone (rth) is a syndrome in which patients have elevated thyroid hormone (th) levels and decreased sensitivity to its action. we describe a child with extreme rth and a severe phenotype. a 22-month-old female presented to the nih with goiter, growth retardation, short stature, and deafness. additionally, the patient had hypotonia, mental retardation, visual impairment, and a history of seizures. brain magnetic resonance imaging showed evidence of demyelination and bilate ... | 2001 | 11701667 |
| atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of total and tree t4 and free t3 with reciprocal increase in tsh. | the present investigation was designed to determine whether atrial natriuretic peptides (anps) consisting of amino acids 1-30 [i.e. long-acting natriuretic hormone (lanh)], 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone [anh]) of the 126-amino acid anh prohormone decrease the circulating concentrations of total and free t4 and/or free t3 in healthy humans (n = 30). vessel dilator, kaliuretic hormone, lanh, and anh decreased the circulating concentratio ... | 2001 | 11701719 |
| patterns of abnormal fdg uptake by various histological types of non-small cell lung cancer at initial staging by pet. | the aim of this study was to identify useful patterns of abnormal fluorine-18 fluorodeoxyglucose (fdg) uptake by different types of non-small cell (nsc) lung cancer and to assess their clinical implications. one hundred and three sequential patients with newly diagnosed, pathology-proven nsc lung cancer were included. fdg positron emission tomography (pet) images were acquired using a dedicated pet scanner. there were 35 squamous cell carcinomas (sqc), 17 large cell cancers (lgc), 38 adenocarcin ... | 2001 | 11702114 |
| validation of a novel high-sensitivity radioimmunoassay procedure for measurement of total thyroxine concentration in psittacine birds and snakes. | to validate a novel high-sensitivity radioimmunoassay (ria) procedure developed to accurately measure the relatively low serum total thyroxine (t4) concentrations of birds and reptiles and to establish initial reference ranges fort4 concentration in selected species of psittacine birds and snakes. | 2001 | 11703019 |
| prognostic significance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in voided urine samples from patients with transitional cell carcinoma of the bladder. | to study the role of urinary matrix metalloproteinase-1 (mmp-1) and tissue inhibitor of metalloproteinase-1 (timp-1) in bladder cancer and their relationship to tumor progression. | 2001 | 11705862 |
| [subclinical thyroid disease in institutionalised healthy geriatric population]. | our aim was to determine the prevalence of subclinical thyroid disease in a healthy institutionalised geriatric population. | 2001 | 11707219 |
| [significant role of cisplatin and 5-fu combination chemotherapy for first-line intensive treatment for advanced esophageal cancer]. | we evaluated the efficacy of first-line chemotherapy consisting of cisplatin and 5-fluorouracil combination therapy (in the following, fp) in intensive treatment for esophageal cancer. this first-line chemotherapy was administered to 18 patients with squamous cell carcinoma. three patients had t2 tumor, 10 had t3 and 5 had t4. lymph node metastasis was detected in 10 patients and not detected in 8 patients. five patients had distant metastasis. ten patients showed a partial response and the resp ... | 2001 | 11707991 |
| [efficacy of intraperitoneal chemotherapy for peritoneal recurrence of gastric carcinoma]. | we report a patient in whom intraperitoneal chemotherapy was effective against peritoneal recurrence of gastric carcinoma. a 74-year-old woman underwent total gastrectomy with splenectomy and transverse colectomy for borrmann type iv gastric carcinoma (curability b) in january 2000. the diagnosis was stage iv gastric carcinoma (t4, n2, p1, h0, m0 and cy0). in july 2000, peritoneal recurrence occurred along with slight elevation of cea. in september, two ports were inserted into the upper and low ... | 2001 | 11708002 |
| familial and sporadic forms of central core disease are associated with mutations in the c-terminal domain of the skeletal muscle ryanodine receptor. | central core disease (ccd) is an autosomal dominant congenital myopathy. diagnosis is based on the presence of cores in skeletal muscles. ccd has been linked to the gene encoding the ryanodine receptor (ryr1) and is considered to be an allelic disease of malignant hyperthermia susceptibility. however, the report of a recessive form of transmission together with a variable clinical presentation has raised the question of the genetic heterogeneity of the disease. analyzing a panel of 34 families e ... | 2001 | 11709545 |
| caveolin-1 expression is associated with high-grade bladder cancer. | to assess the levels of caveolin-1 in a series of bladder tumor specimens of varying stage and grade and to identify possible links between caveolin-1 status and clinical behavior. caveolae have emerged as sites of important regulatory events at the cell membrane in many different cell types. caveolins are the main structural components of caveolae and belong to a family of highly conserved integral membrane proteins. the function of caveolin-1 appears to be intrinsically linked to cell signalin ... | 2001 | 11711373 |
| pelvic wall involvement denotes a poor prognosis in t4 rectal cancer. | an aggressive surgical approach with en bloc resection of involved structures is often possible with anterior rectal cancers that invade adjacent visceral organs, but is rarely possible in tumors that invade the pelvic wall. however, most staging systems include both situations in the same group of t4 rectal cancers. we performed a retrospective study of patients with stage t4 rectal cancer undergoing surgery to assess the influence of different organ involvement on resectability and survival. | 2001 | 11711741 |
| identifying patients with t3-t4 node-negative colon cancer at high risk of recurrence. | adjuvant chemotherapy is effective for node-positive colon cancer patients. in node-negative patients, it could be justified in high-risk patients. the purpose of this study was to determine clinical and pathological findings associated with tumor recurrence in t3-t4 node-negative colon cancer patients. | 2001 | 11711742 |
| skin melanoma in saarland: incidence, survival and mortality 1970-1996. | over the past few decades, the incidence of cutaneous malignant melanoma has been rising in both sexes in almost all developed countries, notably those with fair-skinned populations. detailed population-based time trend analyses of skin melanoma incidence and survival in germany accounting for stage have not been published until now. we analysed skin melanoma data from the population-based saarland cancer registry in germany from 1970 to 1996. incidence rates were age-standardized. we estimated ... | 2001 | 11711755 |
| off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. | oxidative stress and renal dysfunction occur in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (on-pump cabg). whether the same adverse effects also occur during off-pump cabg is the question in this study. | 2001 | 11675176 |
| [brain metastases from esophageal cancers: clinical features and treatment results]. | metastatic brain tumors from esophageal cancer are relatively rare. we analyzed the clinical features and results of treatment in 14 cases of brain metastases from esophageal carcinoma. the average time to diagnosis of brain metastases in the 11 patients with metachronous lesions was 13 months. the average age of patients at the diagnosis of brain metastasis was 65 years. most patients had t4 or n1 disease at the time of diagnosis of esophageal cancer. performance status of grade 3 was most freq ... | 2001 | 11676170 |
| characterization and mapping of dna damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) at nucleotide resolution in human genomic dna. | the nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) is an important tobacco-specific carcinogen associated with lung cancer. its complex enzymatic activation, leading to methyl and pyridyloxobutyl (pob)-modified dna, makes dna damage difficult to characterize and quantify. therefore, we use the nnk analogue 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (nnkoac) to induce damage in genomic dna, and to map the sites and frequency of adducts at nucleotide resolution using ... | 2001 | 11676538 |
| oxygen free radical damage to dna. translesion synthesis by human dna polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. | cyclopurine deoxynucleosides are common dna lesions generated by exposure to reactive oxygen species under hypoxic conditions. the s and r diastereoisomers of cyclodeoxyadenosine on dna were investigated separately for their ability to block 3' to 5' exonucleases. the mammalian dna-editing enzyme dnase iii (trex1) was blocked by both diastereoisomers, whereas only the s diastereoisomer was highly efficient in preventing digestion by the exonuclease function of t4 dna polymerase. digestion in bot ... | 2001 | 11677235 |
| the effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. | many hyperthyroid cats referred for thyroid imaging and 131i therapy are concurrently or recently receiving antithyroid medications. the effect of the antithyroid drug, methimazole, on thyroid uptake of 99mtco4 and 123i was evaluated in 8 normal cats. quantitative analysis was used to determine the normal percent dose uptake of 99mtco4 and 123i, the change in thyroid:salivary ratios (t:s) of 99-tco4 over time, and the duration of the methimazole effect on thyroid uptake of 123i. methimazole was ... | 2001 | 11678569 |
| thyroid function in the newborn in relation to maternal thyroid status during labour in a mild iodine deficiency endemic area in sudan. | data on neonatal and maternal thyroid function during labour in a mild iodine deficiency endemic area are lacking. the current study focuses on elucidating the thyroid function during labour, in a group of pregnant women who live in an area of mild iodine deficiency in sudan compared to that observed in their corresponding newborns. | 2001 | 11678831 |
| long-term follow-up of contralateral lobe in patients hemithyroidectomized for solitary follicular adenoma. | since there are no available conclusive studies on the long-term evolution of remnant thyroid tissue after hemithyroidectomy in patients who undergo surgery for solitary follicular adenomas, we searched for such cases in our records to elucidate this issue. | 2001 | 11678834 |
| practical approach to patients presenting with multiple synchronous suspect lung lesions: a reflection on the current tnm classification based on 54 cases with complete follow-up. | to examine the survival after surgical treatment of patients presenting with two synchronous suspect lung lesions, and to reflect on the recent tnm classification, which has upgraded patients with two malignant lung lesions of the same histology into the t4 (both lesions in the same ipsilateral lobe) or m1 (different lobes or lungs) category. | 2001 | 11679175 |
| comparison of hydro-us and spiral ct in the staging of gastric cancer. | the purpose of this study was to compare the diagnostic accuracy of hydro-ultrasonography (us) and spiral computed tomography (ct) in the staging of gastric cancer. forty-three patients with gastric cancers confirmed at surgery underwent hydro-us and spiral ct on the same day prospectively. hydro-us and spiral ct were done after ingestion of water. us and ct images were independently analyzed. after surgery, pathological findings according to tnm classification were compared with us and ct findi ... | 2001 | 11679225 |
| in vivo accuracy of thoracic pedicle screws. | a retrospective observational study of 279 transpedicular thoracic screws using postoperative computed tomography (ct). | 2001 | 11679819 |
| [surgical strategy in rectosigmoidal cancer]. | colorectal cancer is frequent and diagnosed earlier thanks to the screening and to the progresses in the preoperative assessment. the precocity of the surgical resection takes advantage from the complete resection of vascular and nodes involvement. the rectal localisation of the cancer requires to take the reconstruction into account. if preoperative radiotherapy is helpful in t4 and t3 n2 and locally advanced tumour, the surgeon should consider the four approaches of rectal cancer: the anterior ... | 2001 | 11680177 |
| children with non-verbal learning disabilities (nld): coherence values in the resting state may reflect hypofunctional long distance connections in the right hemisphere. | eeg intrahemispheric coherences (hcohs) in the resting state in twenty-four 4 hz frequency windows between 1 and 51 hz were studied in 18 children with "non-verbal learning disorder" (nld) and compared to a group of 18 children with "verbal learning disorder" (vld). new facts were found in the nld group. these concern hemispheric balance, expressed as left minus right (l-r) homologous hcohs: 1a). in the high frequencies (25-51 hz) the number of long-distance hcohs, higher in the right hemisphere ... | 2001 | 11680298 |
| [survival benefits of and indications for extended surgery for advanced gastric cancer]. | the surgical management of locally advanced gastric cancer remains controversial. it is also unclear whether the postoperative survival rate could be improved by extended lymph node dissection. the aim of this paper is to determine the survival benefit of and the indications for extended surgery. lymph node metastasis in the paraaortic area frequently occurs in locally advanced cardiac cancer. in our previous studies, the paraaortic lymph nodes above and below the left renal vein were confirmed ... | 2001 | 11681003 |
| differential expression of na:k:2cl cotransporter, glucose transporter 1, and aquaporin 1 in freshly isolated and cultured bovine corneal tissues. | little is known about whether culturing corneal limiting layers causes changes in the expression of their membrane transporter proteins from those present in fresh tissues. accordingly, we compared mrna abundance of three well-described types of transporters: water channel aquaporin 1 (aqp1), glucose transporter (glut1), and na:k:2cl cotransporter (nkcc), as well as nkcc protein levels in fresh bovine corneal epithelium and endothelium with those in their cultured counterparts. abundance of mrna ... | 2001 | 11682698 |
| bone mineral density in male patients with l-thyroxine suppressive therapy and graves disease. | little is known about the effects of thyroid hormone excess in male patients. our aim was to evaluate bone mineral density (bmd), bone turnover markers, and thyroid function in male patients with treated thyroid cancer on long-term suppressive l-t4 therapy (tc) and in male patients with graves' disease (gd). we studied 49 male patients (aged 45+/-12 years), 17 with tc (29-288 months on l-t4 suppressive therapy; free t4: 1.9+/-0.6 ng/dl [normal< or =2.0]; tsh: 0.2+/-0.3 microu/ml [normal 0.5-5.0] ... | 2001 | 11683428 |
| selenium, selenoproteins and human health: a review. | selenium is of fundamental importance to human health. it is an essential component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defence systems, and immune function. the decline in blood selenium concentration in the uk and other european union countries has therefore several potential public health implications, particularly in relation to the chronic disease prevalence of the western world such as cancer and cardiovascular disease. ten years have elap ... | 2001 | 11683552 |
| intraoperative epidural blockade prevents the increase in protein breakdown after abdominal surgery. | the aim of this study was to investigate the effect of epidural blockade with bupivacaine, restricted to the intraoperative period, on protein catabolism after major abdominal surgery. | 2001 | 11683666 |
| upper tract transitional cell carcinoma following cystectomy for bladder cancer. | we assessed the incidence of upper urinary tract tumors (uutts) after cystectomy for invasive or superficial transitional cell carcinoma (tcc) of the bladder. the risk factors, patients' characteristics and evolution of those who developed uutts are analyzed. | 2001 | 11684849 |
| preoperative radiochemotherapy and sphincter-saving resection for t3 carcinomas of the lower third of the rectum. | to evaluate the complications and oncologic and functional results of preoperative radiochemotherapy and sphincter-saving resection for t3 cancers of the lower third of the rectum. | 2001 | 11685026 |
| studying excited states of proteins by nmr spectroscopy. | protein structure is inherently dynamic, with function often predicated on excursions from low to higher energy conformations. for example, x-ray studies of a cavity mutant of t4 lysozyme, l99a, show that the cavity is sterically inaccessible to ligand, yet the protein is able to bind substituted benzenes rapidly. we have used novel relaxation dispersion nmr techniques to kinetically and thermodynamically characterize a transition between a highly populated (97%, 25 degrees c) ground state confo ... | 2001 | 11685237 |
| autonomic dysreflexia and primary afferent sprouting after clip-compression injury of the rat spinal cord. | spinal cord injury leads to many forms of autonomic dysfunction including autonomic dysreflexia, a condition involving recurrent episodes of paroxysmal hypertension and associated bradycardia. this hypertension may reach intensities that are life-threatening. we investigated autonomic dysreflexia and the sprouting of central processes of primary afferent neurons (a potential mechanism for autonomic dysreflexia) in a clinically-relevant calibrated clip-compression model of spinal cord injury in t ... | 2001 | 11686496 |
| [anterior chest wall reconstruction with myocutaneous flap after open drainage for infectious bulla and empyema following t4 lung cancer resection via anterior approach]. | a 48-year-old man with t4 lung cancer underwent resection of the right upper lobe, chest wall, and superior vena cava, and reconstruction of the last 2 tissues via anterior approach after induction chemo-radiotherapy. however, a bulla in the apical segment of the lower lobe divided by stapling was infected after the operation, and open drainage through the anterior chest wall was mandatory due to massive air leak and spread of infection to the pleural space. as the incision were fortunately rest ... | 2001 | 11712368 |
| [two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (pas)-induced hypothyroidism]. | two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (pas)-induced hypothyroidism were reported. case 1; a 73-year-old male, complaining of edema, was admitted to our hospital. he had been treated for his multi-drug-resistant pulmonary tuberculosis during the past 1 year with an antituberculous regimen consisting of ethambutol (eb), ethionamide (eth) and pas. a thyroid profile performed when he was admitted to our hospital showed several marked abnormalities: se ... | 2001 | 11712388 |
| loss of heterozygosity and its correlation with clinical outcome and epstein-barr virus infection in nasopharyngeal carcinoma. | sixty-one human nasopharyngeal carcinomas (npc) were examined by allelotype analysis for the purposes of detecting potential association between loss of heterozygosity (loh), clinicopathological parameters and epstein-barr virus (ebv) infection. loh was performed using 257 polymorphic markers on 22 chromosomes. high frequency loh (> or = 60%) was observed on 12 chromosome arms including 1p, 2p, 2q, 3p, 3q, 5q, 9p. 9q, 11q, 13q, 14q and 17q, with the highest loh frequency of 91% on 3p. seventy-th ... | 2001 | 11712805 |
| radiotherapy alone for clinical t4 skin carcinoma of the head and neck with surgery reserved for salvage. | to evaluate the outcomes of definitive radiotherapy in the treatment of clinical stage t4 cutaneous carcinomas of the head and neck. | 2001 | 11713722 |
| cancer of the buccal mucosa: are margins and t-stage accurate predictors of local control? | cancer of the buccal mucosa is an uncommon and aggressive neoplasm of the oral cavity. less than 2% of patients treated for cancer of the oral cavity at roswell park cancer institute (rpci) from 1971 to 1997 had primary buccal cancers. because the majority of these patients did not undergo any adjuvant treatment, this group provided us with the opportunity to assess the relationship between margin status and local recurrence for both small (t1-t2) and large (t3-t4) tumors treated with surgery al ... | 2001 | 11713724 |
| phytoextraction of cd and pb and physiological effects in potato plants (solanum tuberosum var. spunta): importance of root temperature. | three consecutive years of field experiments were carried out to investigate the effect of different root-zone temperatures, induced by the application of mulches, on the concentration and accumulation of cd and pb and on bioindicators (chlorophylls, catalase, peroxidase and cell wall fractions) in different organs of potato plants (roots, tubers, stems, and leaflets). four different plastic covers were employed (t1, transparent polyethylene; t2, white polyethylene; t3, white and black coextrude ... | 2001 | 11714328 |
| epidermoid cyst of the thoracic spine: case history. | epidermoid cysts of the spinal cord are very rare tumors. we report a 31 year-old female who presented with a 5 months history of progressive lower extremity weakness and spasticity. magnetic resonance imaging of the thoracic spine revealed a 2 cm intradural, extramedullary mass at the t4-5 level. a t4 and t5 osteoplastic laminotomy with complete removal of the intradural mass was performed. intraoperative and final histological examination revealed an epidermoid cyst. epidermoid cysts must be a ... | 2001 | 11714565 |
| [target volume in radiotherapy of gastric adenocarcinoma]. | the spread of gastric adenocarcinoma may follow three main patterns: hematogenic, lymphatic and intraperitoneal. a gtv should be considered in preoperative or exclusive radiation therapy. after non-radical surgery, a "residual gtv" will be defined with the help of the surgeon. the ctv encompasses three intricated volumes. a) a "tumor bed" volume. after radical surgery, local recurrences appear as frequent as distant metastases. the risk depends upon the depth of parietal invasion and the nodal s ... | 2001 | 11715304 |
| type 2 iodothyronine deiodinase expression is upregulated by the protein kinase a-dependent pathway and is downregulated by the protein kinase c-dependent pathway in cultured human thyroid cells. | type 1 and 2 iodothyronine deiodinases (d1 and d2) catalyze thyroxine (t4) activation. in human thyroid, unlike rodents', both d1 and d2 are expressed. we have investigated the effects of thyrotropin (tsh), dibutyryl cyclic adenosine monophosphate [(bu)2camp] (an activator of protein kinase a [pka]), 12-o-tetradecanoylphorbor 13-actate (tpa) (an activator of protein kinase c [pkc]), t4, and triiodothyronine (t3) on the d2 mrna levels and activity in cultured human thyroid cells. d2 mrna levels w ... | 2001 | 11716036 |
| effect of 131 iodine therapy on the course of graves' ophthalmopathy: a quantitative analysis of extraocular muscle volumes using orbital magnetic resonance imaging. | there remains uncertainty as to the effect of radioactive iodine (131i) therapy on the associated ophthalmopathy (go). twenty newly diagnosed patients with graves' hyperthyroidism treated with 131i (median dose, 15.5 mci) were followed with ophthalmologic evaluations (oe) and magnetic resonance imaging (mri) at baseline, 2, and 6 months, and with oe alone at 3 years. for mri, the superior, inferior, and medial rectus muscle volumes and total muscle volumes (tmv) were measured. replacement levoth ... | 2001 | 11716044 |
| the acute effect of calcium carbonate on the intestinal absorption of levothyroxine. | to determine the acute effect of calcium, we measured levothyroxine absorption after ingestion of thyroxine (t4) with and without simultaneous ingestion of calcium (as calcium carbonate) in seven volunteers without thyroid disease. serum total t4, total triiodothyronine (t3), free t4, and thyrotropin (tsh) levels were measured after ingestion of 1,000 microg of levothyroxine on two separate visits at 4-week intervals: (1) levothyroxine alone and (2) levothyroxine together with 2.0 g of calcium a ... | 2001 | 11716045 |
| aggressive metastatic follicular thyroid carcinoma with anaplastic transformation arising from a long-standing goiter in a patient with pendred's syndrome. | in this article we describe detailed pathological and molecular genetics studies in a consanguineous kindred with pendred's syndrome. the index patient was a 53-year-old female patient with congenital deafness and goiter. her parents were first-degree cousins. she had a large goiter (150 g) that had been present since childhood. one of her sisters and a niece are also deaf and have goiter as well. the presence of pendred's syndrome was confirmed by a positive perchlorate test and the demonstrati ... | 2001 | 11716048 |
| invasive staging of lung cancer by mediastinoscopy and video-assisted thoracoscopy. | accurate evaluation of the outcomes of clinical trials using preoperative chemotherapy in a multimodality treatment protocol may require invasive pretreatment staging for pathologic confirmation of the clinical tnm. mediastinoscopy and videothoracoscopy complement each other to provide appropriate staging of lung cancer. invasive staging utilizing both methods may accurately determine the presence or absence of n2 and n3 disease, and identify t3 or t4 or thoracic m1 disease. | 2001 | 11740986 |
| cooperativity in drug-dna recognition: a molecular dynamics study. | nmr studies have shown that the minor groove-binding ligand hoechst 33258 binds to the two t4/a4 tracts within the duplex d(cttttcgaaaag)2 in a highly cooperative manner, such that in titration experiments no intermediate 1:1 complex can be detected. the nmr-derived structures of the free dna and the 2:1 complex have been obtained, but can shed little light on what the origins of this cooperativity may be. here we present the results of a series of molecular dynamics simulations on the free dna, ... | 2001 | 11741431 |
| impact of modified radical neck dissection on biochemical cure in medullary thyroid carcinomas. | this study evaluated the outcome of total thyroidectomy and modified radical neck dissection in primary treatment of patients with medullary thyroid carcinoma (mtc). | 2001 | 11742336 |
| contact heat evoked potentials as a valid means to study nociceptive pathways in human subjects. | contact heat evoked potentials (cheps) have been difficult to elicit due to slow temperature rise times. a recently developed heat-foil technology was used to elicit pain and cheps. two groups of subjects were separately stimulated at the left arm with contact heat via one fast-acting (70 degrees c/s) heat-foil thermode. a set of cheps was recorded, each at three subjective intensities: warm; slight; and moderate pain. in cheps, the 3d topography exhibited four components: t3-t4/n450; cz/n550; c ... | 2001 | 11742720 |
| flipping a genetic switch by subunit exchange. | the bacteriophage t4 asia protein is a multifunctional protein that simultaneously acts as both a repressor and activator of gene expression during the phage life cycle. these dual roles with opposing transcriptional consequences are achieved by modification of the host rna polymerase in which asia binds to conserved region 4 (sr4) of sigma(70), altering the pathway of promoter selection by the holoenzyme. the mechanism by which asia flips this genetic switch has now been revealed, in part, from ... | 2001 | 11742991 |
| congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (r218h) in the human albumin gene. | we found familial dysalbuminemic hyperthyroxinemia (fdh) in a 5-month-old boy with congenital hypothyroidism (ch) who had a blood thyrotropin (tsh) level of 479 mu/l but normal total serum thyroxine (t4) and higher than normal total triiodothyronine (t3) levels. thyroid hormone substitution began at 5 weeks of age when t4 and t3 concentrations were below normal. until the age of 5 months, treatment with levothyroxine was suboptimal on the basis of high serum tsh levels despite above-normal t4 le ... | 2001 | 11743520 |
| crystal structure of a heat and protease-stable part of the bacteriophage t4 short tail fibre. | adsorption of t4 bacteriophage to the escherichia coli host cell is mediated by six long and six short tail fibres. after at least three long tail fibres have bound, short tail fibres extend and bind irreversibly to the core region of the host cell lipopolysaccharide (lps), serving as inextensible stays during penetration of the cell envelope by the tail tube. the short tail fibres consist of a parallel, in-register, trimer of gene product 12 (gp12). the 1.9 a crystal structure of a heat and pro ... | 2001 | 11743729 |
| equi-lasting doses of rocuronium, compared to mivacurium, result in improved neuromuscular blockade in patients undergoing gynecological laparoscopy : [des doses de durée équivalente de rocuronium, comparé au mivacurium, améliorent la curarisation chez des patientes qui subissent une laparoscopie gynécologique]. | to compare equi-lasting doses of a short-acting (mivacurium) to an intermediate-acting (rocuronium) neuromuscular relaxant, with regard to intubating conditions, efficacy, number of maintenance doses, hemodynamic alterations, adverse events and costs, in patients undergoing laparoscopic gynecological surgery. | 2001 | 11744584 |
| surgical treatment of stage iii non-small cell lung cancer. | the resectability of nsclc is determined by its stage. the surgical treatment in stage i and ii nsclc remains a golden standard. stage iiia nsclc constitutes a non-homogenous group, and many patients are potentially non-resectable. the patients in stage iiia nsclc also constitute a non-homogenous group. the patients in stage t3n1 usually undergo surgical resection, but many patients with n2 disease are disqualified from surgical treatment due to the negative prognostic factors. the negative prog ... | 2001 | 11720755 |
| binding of nucleotides by t4 dna ligase and t4 rna ligase: optical absorbance and fluorescence studies. | the interaction of nucleotides with t4 dna and rna ligases has been characterized using ultraviolet visible (uv-vis) absorbance and fluorescence spectroscopy. both enzymes bind nucleotides with the k(d) between 0.1 and 20 microm. nucleotide binding results in a decrease of absorbance at 260 nm due to pi-stacking with an aromatic residue, possibly phenylalanine, and causes red-shifting of the absorbance maximum due to hydrogen bonding with the exocyclic amino group. t4 dna ligase is shown to have ... | 2001 | 11721015 |
| [thyroid hormones, obesity and brown adipose tissue thermogenesis]. | brown adipose tissue (bat) is the main site for hormone-dependent (non-shivering) thermogenesis in response to cold in lower mammals. the hypothalamus controls the cold-induced bat activation by stimulating the sympathetic nerves and the secretion of norepinephrine (ne) in bat. mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (t3), ne promotes the synthesis of the uncoupling protein 1 (ucp1). ucp1 is a 32 kda protein located in the inner membrane of bat mitochond ... | 2001 | 11721329 |
| influence of feeding level during postweaning growth on circulating concentrations of thyroid hormones and extrathyroidal 5'-deiodination in steers. | an experiment was conducted with 42 growing montbéliard steers to study the effect of feed restriction, followed by refeeding, on circulating concentrations of thyroxine (t4) and triiodothyronine (t3) and on hepatic and muscle activities of 5'-deiodinase (5'd). at 9 mo of age, 21 steers were diet-restricted for 3 mo (adg, 641 g/d), prior to a 4-mo compensatory growth period with ad libitum access to the same diet (adg, 1,240 g/d). they were compared to 21 control steers continuously gaining 1,10 ... | 2001 | 11721848 |
| combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of lung cancer. | this study seeks to assess the safety and usefulness of combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of patients with lung cancer. | 2001 | 11722067 |
| thyroid function test abnormalities in newly admitted psychiatric patients residing in an iodine-deficient area: patterns and clinical significance. | the prevalence of abnormal in-vitro thyroid function tests in psychiatric in-patients may be as high as 24%. thus far, however, there is only limited data addressing the underlying causes of these abnormal test results, i.e. how often they can be attributed to genuine thyroid disease. | 2001 | 11722306 |
| effect of mivacurium 200 and 250 &mgr;g/kg in infants during isoflurane anesthesia: a randomized controlled trial [isrctn07742712]. | background: infants usually respond differently to a neuromuscular relaxant compared to children or adults. isoflurane is commonly used as an anesthetic gas in infants. in an rct design, we investigated whether a dose of mivacurium 250 &mgr;g/kg results in faster onset of action than 200 &mgr;g/kg in infants under isoflurane anesthesia. spontaneous recovery times and cardiovascular response were also evaluated. methods: twenty-four low surgical risk children, aged 6-24 months, undergoing an elec ... | 2001 | 11722796 |
| comparison of dna damage photoinduced by ketoprofen, fenofibric acid and benzophenone via electron and energy transfer. | ketoprofen (kp) and fenofibrate, respectively, anti-inflammatory and hypolipidemiant agents, promote anormal photosensitivity in patients and may induce photoallergic cross-reactions correlated to their benzophenone-like structure. here, their ability to photosensitize the degradation of biological targets was particularly investigated in dna. the photosensitization of dna damage by kp and fenofibric acid (fb), the main metabolite of fenofibrate, and their parent compound, benzophenone (bz), was ... | 2001 | 11723794 |
| outcomes of radiotherapy for inoperable locally advanced (t4) esophageal cancer-retrospective analysis-. | to assess the treatment outcome after radiotherapy with or without chemotherapy for inoperable locally advanced (t4) esophageal cancer (ec), a retrospective analysis was performed. we enrolled 37 patients with t4 ec and analyzed 35 patients. a total of 28 patients were treated with radiotherapy and chemotherapy (median dose, 60 gy) and seven patients were treated with radiation alone (median dose, 60 gy). many mainly received high-dose cisplatin (cddp) and 5-fluorouracil (fu) or continuous infus ... | 2001 | 11724253 |
| [treatment of euthyroid goiter in the elderly]. | a study was conducted to evaluate the effectiveness of the medical therapy with synthetic hormone levothyroxine (l-t4) in the elderly subjects with multinodular euthyroid goiter. | 2001 | 11725614 |
| huge response to letrozole in inoperable t4 breast cancer: a case report. | a 73 years-old woman presented with locally advanced breast cancer (ct4b cn1 m0, stage iiib) and atrial flutter. because of the arrhythmia, chemotherapy or tamoxifen, although malignancy was hormone-sensitive, were discarded. letrozole was started. two months later, the breast nodule and skin ulceration cleared up. surgery was performed. nowadays, 24 months later, patient does fine, continuing letrozole as adjuvant treatment. | 2001 | 11725620 |
| nasopharyngeal carcinomas: analysis of patient, tumor and treatment characteristics determining outcome. | the present study reviews the experience in treatment of 447 patients with nasopharyngeal carcinomas, analyzing patient, tumor and treatment characteristics determining outcome. | 2001 | 11730993 |
| ablation of tralpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice. | thyroid hormone governs a diverse repertoire of physiological functions through receptors encoded in the receptor genes alpha and beta, which each generate variant proteins. in mammals, the alpha gene generates, in addition to the normal receptor tralpha1, a non-hormone-binding variant tralpha2 whose exact function is unclear. here, we present the phenotype associated with the targeted ablation of tralpha2 expression. selective ablation of tralpha2 resulted in an inevitable, concomitant overexpr ... | 2001 | 11731613 |
| thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. | mice homozygous for the targeted disruption of the glycoprotein hormone alpha-subunit (alphagsu) display hypertrophy and hyperplasia of the anterior pituitary thyrotropes. thyrotrope hyperplasia results in tumors in aged alphagsu(-/-) mice. these adenomatous pituitaries can grow independently as intrascapular transplants in hypothyroid mice, suggesting that they have progressed beyond simple hyperplasia. we used magnetic resonance imaging to follow the growth and regression of thyrotrope adenoma ... | 2001 | 11731614 |
| targeted disruption of the type 2 selenodeiodinase gene (dio2) results in a phenotype of pituitary resistance to t4. | the type 2 deiodinase (d2), a selenoenzyme that catalyzes the conversion of t4 to t3 via 5'-deiodination, is expressed in the pituitary, brain, brown adipose tissue (bat), and the reproductive tract. to examine the physiological role of this enzyme, a mouse strain lacking d2 activity was developed using homologous recombination. the targeting vector contained the neo gene in place of a 2.6-kb segment of the dio2 gene. this segment comprises 72% of the coding region and includes the tga codon tha ... | 2001 | 11731615 |
| liver and renal function after volatile induction and maintenance of anesthesia (vima) with sevoflurane versus tiva with sufentanil-midazolam for cabg surgery. | we compared liver and renal function after volatile induction and maintenance of anesthesia (vima) with sevoflurane and minimal dose sufentanil versus total intravenous anesthesia (tiva) with moderate dose of midazolam and sufentanil in patients undergoing cabg surgery. eighty nine patients were studied retrospectively after vima (44 patients) or after tiva (45 patients). liver and renal function were measured before (t0), then 1 (t1), 2 (t2), 5 (t3) days and 6 weeks (t4) after the operation. se ... | 2001 | 11732384 |
| follicular development and ovulation in hypothyroid rdw rats. | in this paper, we summarized our recent studies on follicular development and ovulation in the presence or absence of thyroxine (t4) and equine chorionic gonadotrophin (ecg) treatment in infertile immature spontaneously hypothyroid rdw rats. t4 therapy once daily from postnatal day 21 to day 29 resulted in increases in ovarian weight on day 30 (p 0.01). similar populations of both healthy and atretic antral follicles ranging in diameter from 101-400 microm were observed in control rdw and normal ... | 2001 | 11732584 |
| the chaperonins of synechocystis pcc 6803 differ in heat inducibility and chaperone activity. | the chaperonins groel and cpn60 were isolated from the cyanobacterium synechocystis pcc 6803 and characterized. in cells grown under optimal conditions their ratio was about one to one. however, the amount of groel increased considerably more than that of cpn60 in response to heat stress. the labile chaperonin oligomer required stabilization by mgatp or glycerol during isolation. use of the e. coli mutant strain, groel44 revealed that the functional properties of the two cyanobacterial chaperoni ... | 2001 | 11735133 |
| a zinc ribbon protein in dna replication: primer synthesis and macromolecular interactions by the bacteriophage t4 primase. | the gene product 61 primase protein from bacteriophage t4 was expressed as an intein fusion and purified to homogeneity. the primase binds one zinc ion, which is coordinated by four cysteine residues to form a zinc ribbon motif. factors that influence the rate of priming were investigated, and a physiologically relevant priming rate of approximately 1 primer per second per primosome was achieved. primase binding to the single-stranded binding protein (1 primase:4 gp32 monomers; k(d) approximatel ... | 2001 | 11735390 |
| bone or cartilage invasion by advanced head and neck cancer: intra-arterial supradose cisplatin chemotherapy and concomitant radiotherapy for organ preservation. | invasion of bony or cartilaginous structures by advanced upper aerodigestive tract cancer has been considered an indication for surgery on the basis of historic experience of poor responsiveness to radiation therapy. at university of tennessee-memphis, patients with advanced head and neck cancer have been treated on a protocol of concomitant intra-arterial (targeted) cisplatin and conventional radiation therapy. | 2001 | 11735813 |
| non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer. | tumour neoangiogenesis can be assessed non-invasively by measuring angiogenic cytokine concentrations in peripheral circulation and by dynamic contrast-enhanced magnetic resonance imaging (dce-mri). the aim of this study was to assess whether these methods can predict and monitor response to treatment in patients with rectal cancer treated with preoperative chemoradiotherapy. | 2001 | 11736977 |
| expense and benefit of neoadjuvant treatment in squamous cell carcinoma of the esophagus. | the effectiveness of neoadjuvant treatment (nt) prior to resection of squamous cell carcinoma of the esophagus (scce) in terms of prolonged survival has not been proven by randomized trials. facing considerable financial expenses and with concerns regarding the consumption of the patient's remaining survival time, this study aims to provide rationales for pretreating resection candidates. | 2001 | 11737874 |
| thyroid hormone substitution therapy rapidly enhances left-ventricular diastolic function in hypothyroid patients. | alterations in thyroid status may lead to changes in both systolic and diastolic function of the heart. pulsed doppler echocardiography is a reliable non-invasive means of assessing left-ventricular (lv) diastolic function. the aim of the present study was to evaluate lv diastolic function in patients with primary hypothyroidism receiving thyroxine therapy. | 2001 | 11740133 |
| percutaneous ethanol injection of autonomous thyroid nodules with a volume larger than 40 ml: three years of follow-up. | autonomous thyroid nodules are conventionally treated by surgery or radioiodine. percutaneous ethanol injection is a recognized alternative approach. an assessment of the long-term success and safety was conducted. | 2001 | 11603892 |
| predictive value of altered p27kip1 and p21waf/cip1 protein expression for the clinical prognosis of patients with localized prostate cancer. | the p21waf/cip and the p27kip1 genes have been identified as inductors of cell cycle arrest at the g1-checkpoint. alterations of both genes have been suggested to be involved in the development of a variety of human malignancies due to a loss of critical antiproliferative mechanisms. to evaluate the prognostic importance of these alterations for patients with clinically localized prostate cancer, in 86 specimens (t1-t4) from 86 patients undergoing radical prostatectomy at the department of urolo ... | 2001 | 11605074 |
| the ul6 gene product forms the portal for entry of dna into the herpes simplex virus capsid. | during replication of herpes simplex virus type 1 (hsv-1), viral dna is synthesized in the infected cell nucleus, where dna-free capsids are also assembled. genome-length dna molecules are then cut out of a larger, multigenome concatemer and packaged into capsids. here we report the results of experiments carried out to test the idea that the hsv-1 ul6 gene product (pul6) forms the portal through which viral dna passes as it enters the capsid. since dna must enter at a unique site, immunoelectro ... | 2001 | 11602732 |