Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| resection of cancer of the tongue base and tonsil via the transhyoid approach. | to assess whether transhyoid resection of the tongue base and tonsil lesions is an effective approach to tumors involving this region compared with more traditional anterior surgical approaches that arbitrarily involve either segmental resection or division of the mandible. | 2000 | 11081588 |
| [amiodarone-induced hyperthyroidism]. | amiodarone is extensively used in cardiology practice because of its excellent antiarrhythmic properties. it produces alterations in thyroid functional because it contains 37% iodine and it is structurally similar to the thyroid hormones. amiodarone inhibits 5'-deiodinase in the liver. the incidence of amiodarone-induced hyperthyroidism is between 6% and 12% of treated patients. the figures for pediatric patients are similar. determination of tri-iodothyronine (t3), thyroxine (t4) and thyroid-st ... | 2000 | 11083993 |
| [positive antithyroglobulin antibodies in patients with differentiated thyroid carcinoma. what significance?]. | the aim of this retrospective study was to determine the predictive value of antithyroglobulin antibodies (tgab) in 238 patients with undetectable thyroglobulin after whole thyroidectomy for differentiated cancer and ablative dose of radioiodine. tgab titers were elevated in 30 patients with undetectable tg level after withdrawal of t4 treatment. in 21 patients, initially positive tgab titers became undetectable without clinical event within 3-84 months after therapy (median 12 months). in 2 cas ... | 2000 | 11084393 |
| effect of hyperthyroidism on insulin-like growth factor-i (igf-i) and igf-binding proteins in adolescent children. | a study was performed on adolescent hyperthyroid patients to determine the effects of hyperthyroidism on insulin-like growth factor (igf)-i and its binding proteins. serum concentrations of immunoreactive total and free igf-i, and igf binding protein (igfbp)-2 and igfbp-3 were determined before and after correction of hyperthyroidism in eight patients with grave's disease and compared to control patients matched for age, sex and pubertal stage. the concentration of serum total igf-i was not sign ... | 2000 | 11085184 |
| the somatostatin analogue octreotide modulates iodothyronine deiodinase activity and pituitary neuromedin b. | somatostatin inhibits growth hormone and thyrotropin (tsh) secretion. it also enhances the inhibitory effect of thyroid hormone (th) on tsh by poorly understood mechanisms. we investigated the acute effect of the long-acting somatostatin analogue, octreotide (oct), on anterior pituitary type 1 (d1) and 2 (d2) deiodinase activity, on liver d1, and on pituitary content of neuromedin b (nb), an autocrine inhibitor of tsh secretion, which is positively regulated by thyroid hormones. euthyroid or hyp ... | 2000 | 11014308 |
| [an effective case of intraperitoneal and intra-arterial combined chemotherapy for unresectably advanced borrmann type iv gastric carcinoma]. | we report an effective case of intraperitoneal and intra-arterial combined chemotherapy for unresectably advanced borrmann type iv gastric carcinoma. a 59-year-old man was admitted with advanced borrmann type iv gastric carcinoma in june 1999. with informed consent, the patient underwent laparotomy, which revealed far advanced stage iv gastric carcinoma of t4, n3, p1, h0, m1, cy1 for resection. three ports to both subphrenic pouches and douglas' pouch were placed for intraperitoneal infusion che ... | 2000 | 11086465 |
| t4 early promoter strength probed in vivo with unribosylated and adp-ribosylated escherichia coli rna polymerase: a mutation analysis. | the consensus sequence of t4 early promoters differs in length, sequence and degree of conservation from that of escherichia coli sigma(70) promoters. the enzyme interacting with these promoters, and transcribing the t4 genome, is native host rna polymerase, which is increasingly modified by the phage-encoded adp-ribosyltransferase, alt. t4 early transcription is a very active process, possibly out-competing host transcription. the much stronger t4 promoters enhance viral transcription by a fact ... | 2000 | 11021939 |
| modeling hiv transfer between dendritic cells and t cells: importance of hiv phenotype, dendritic cell-t cell contact and t-cell activation. | to study the requirements for hiv transfer between dendritic cells (dc) and cd4 t cells, using an in vitro model, combined with flow cytometry. | 2000 | 11089618 |
| analysis of the okazaki fragment distributions along single long dnas replicated by the bacteriophage t4 proteins. | rolling circle replication from m13 dna circles was previously reconstituted in vitro using purified factors encoded by bacteriophage t4. the products are duplex circles with linear tails >100 kb. when t4 dna polymerase deficient in 3' to 5' exonuclease activity was employed, electron microscopy revealed short single-stranded dna "flaps" along the replicated tails. this marked the beginning of each okazaki fragment, allowing an analysis of the lengths of sequential okazaki fragments on individua ... | 2000 | 11090619 |
| carcinoma of the maxillary antrum: a retrospective analysis of 110 cases. | cancer of the maxillary antrum is a rare disease with a variety of treatment options. the present study was undertaken to review the outcome of patients with carcinoma of the maxillary antrum managed at a single institution. | 2000 | 11054520 |
| hypothyroidism and depression: a therapeutic challenge. | to describe a patient with longstanding depression and hypothyroidism who had marked mood improvement only after triiodothyronine (t3) was added to her thyroxine (t4) replacement therapy. | 2000 | 11054982 |
| pre-steady state kinetics of bacteriophage t4 dam dna-[n(6)-adenine] methyltransferase: interaction with native (gatc) or modified sites. | the dna methyltransferase of bacteriophage t4 (t4 dam mtase) recognizes the palindromic sequence gatc, and catalyzes transfer of the methyl group from s:-adenosyl-l-methionine (adomet) to the n(6)-position of adenine [generating n(6)-methyladenine and s:-adenosyl-l-homocysteine (adohcy)]. pre-steady state kinetic analysis revealed that the methylation rate constant k(meth) for unmethylated and hemimethylated substrates (0.56 and 0.47 s(-1), respectively) was at least 20-fold larger than the over ... | 2000 | 11058118 |
| formation of cis-diamminedichloroplatinum(ii) 1,2-intrastrand cross-links on dna is flanking-sequence independent. | mapping of cis-diamminedichloroplatinum(ii) (cis-ddp, cisplatin) dna adducts over >3000 nucleotides was carried out using a replication blockage assay. the sites of inhibition of modified t4 dna polymerase, also referred to as stop sites, were analyzed to determine the effects of local sequence context on the distribution of intrastrand cisplatin cross-links. in a 3120 base fragment from replicative form m13mp18 dna containing 24.6% guanine, 25.5% thymine, 26.9% adenine and 23.0% cytosine, 166 i ... | 2000 | 11058123 |
| [contribution of the renin-angiotensin system to blood pressure variability in hyperthyroid rats]. | to produce a chronical thyrotoxicosis model in rat, and to evaluate, using spectral analysis, the involvement of the renin-angiotensin system (ras) in short-term variability of blood pressure (bp) in experimental hyperthyroidism. | 2000 | 10989728 |
| the relationship between thyroxine, oestradiol, and postnatal alopecia, with relevance to women's health in general. | post-partum hair loss is possibly due to a reduction in the levels of oestradiol and thyroxine postnatally. alopecia and/or a persistent loss of hair condition postnatally is associated with a group of symptoms (a syndrome), wherein postnatal depression is significant, as a result of physiologically inadequate levels of thyroxine (t4) and oestradiol (e2), secondary to physiological postnatal anterior pituitary dysfunction. using this hypothesis, the author began to apply the same hypothesis to o ... | 2000 | 11058426 |
| synthesis of dinucleoside polyphosphates catalyzed by firefly luciferase and several ligases. | the findings presented here originally arose from the suggestion that the synthesis of dinucleoside polyphosphates (np(n)n) may be a general process involving enzyme ligases catalyzing the transfer of a nucleotidyl moiety via nucleotidyl-containing intermediates, with release of pyrophosphate. within this context, the characteristics of the following enzymes are presented. firefly luciferase (ec 1.12. 13.7), an oxidoreductase with characteristics of a ligase, synthesizes a variety of (di)nucleos ... | 2000 | 11007993 |
| investigation of the relationship between low apgar scores and early neonatal thyroid function. | the aim of the present study was to assess the effects of low apgar scores on perinatal thyroid function. | 2000 | 11059541 |
| administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. | radioiodine (131i) is increasingly used as treatment for volume reduction of nontoxic, nodular goiter. a high dose of 131i is often needed because of low thyroid radioiodide uptake (raiu). we investigated whether pretreatment with a single, low dose of recombinant human tsh (rhtsh; thyrogen, genzyme transgenics corp.) enhances raiu in 15 patients with nontoxic, nodular goiter (14 women and 1 man; aged 61+/-11 yr). four patients were studied twice, and 1 patient was studied 3 times. raiu was meas ... | 2000 | 11061507 |
| detection of recurrent thyroid cancer by sensitive nested reverse transcription-polymerase chain reaction of thyroglobulin and sodium/iodide symporter messenger ribonucleic acid transcripts in peripheral blood. | to investigate whether circulating thyroglobulin (tg) messenger ribonucleic acid (mrna) and sodium/iodide symporter (nis) mrna transcripts in peripheral blood are valuable in the follow-up of patients with thyroid cancer, we developed highly sensitive nested tg and nis mrna detection assays and compared their accuracy with serum thyroglobulin (stg) and whole body scan with 131i during the monitoring of 34 patients with well differentiated thyroid carcinoma who had undergone total thyroidectomy ( ... | 2000 | 11061512 |
| functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. | frequent blood sampling via intraatrial cannula revealed daily rhythms of tsh and thyroid hormones in both male and female wistar rats. thermic ablation of the biological clock, i.e. the suprachiasmatic nucleus (scn), eliminated the diurnal peak in circulating tsh and thyroid hormones. in addition, scn lesions produced a clear decrease of 24-h mean t4 concentrations. a more pronounced effect of scn-lesions on thyroid hormones, as opposed to tsh, suggested routes of scn control additional to the ... | 2000 | 11014240 |
| a novel mutation causing complete thyroxine-binding globulin deficiency (tbg-cd-negev) among the bedouins in southern israel. | t4-binding globulin (tbg) is the major thyroid hormone transport protein in human serum. inherited tbg abnormalities do not usually alter the metabolic status and are transmitted in x-linked inheritance. a high prevalence of complete tbg deficiency (tbg-cd) has been reported among the bedouin population in the negev (southern israel). in this study we report a novel single mutation causing complete tbg deficiency due to a deletion of the last base of codon 38 (exon 1), which led to a frame shift ... | 2000 | 11061524 |
| hashimoto's thyroiditis: countrywide screening of goitrous healthy young girls in postiodization phase in india. | countrywide salt iodization, to prevent nutritional iodine deficiency, has been achieved in india recently. the current study was planned to evaluate the prevalence of goiter and thyroid autoimmunity and assess thyroid functional status in a cohort of 6283 healthy schoolgirls from different parts of the country in the postiodization phase. goitrous girls (n = 1810; 28% of subjects) were investigated for serum t4 and tsh, antithyroid microsomal antibody (tma) and antithyroglobulin antibody (tga), ... | 2000 | 11061541 |
| comparison of a linear miniature ultrasound probe and a radial-scanning echoendoscope in tn staging of esophageal cancer. | endoscopic ultrasonography is a precise method for tn staging of esophageal cancer. we explored the staging properties of a linear miniprobe as compared with a radial-scanning echoendoscope. | 2000 | 11063164 |
| localization of initial lymph node metastasis from carcinoma of the thoracic esophagus. | most surgeons consider esophageal carcinoma with lymph node involvement a systemic disease. however, it is possible that the disease may be localized in the earlier phases of lymphatic metastasis. the distribution of involved lesions in the initial phase of lymph node metastasis has not been thoroughly investigated yet. | 2000 | 11064342 |
| congruent spinopelvic alignment on standing lateral radiographs of adult volunteers. | radiographs of 75 healthy volunteers were measured to decide parameters and ranges for "congruent" sagittal spinopelvic alignments using the pelvic radius technique. a subset of 30 of the volunteers subsequently had a second radiograph to assess for changes in the repeated measurements. | 2000 | 11064527 |
| the perception of lexical tone in mambila. | the issue of the perception of lexical tone has been addressed mainly through studies of southeast asian languages which feature phonological contour tones as well as level tones. little attention has been paid to african languages which have, almost exclusively, only level tones. this paper examines tone perception in mambila, a benue-congo language with four level lexical tones. a categorization experiment was run to determine some of the salient aspects of the perceptual nature of these tones ... | 2000 | 11064955 |
| salvage radiotherapy for prostate cancer recurrence after cryosurgical ablation. | to retrospectively determine the outcome of patients treated with salvage three-dimensional conformal radiotherapy (rt) for prostate cancer recurrence after cryosurgical ablation of the prostate (csap). biochemical control rates and morbidity were analyzed. | 2000 | 11068312 |
| [clinical epidemiology of basedow's disease in belgium]. | graves' disease (gd) patients treated with antithyroid drugs (atd) have overall relapse rates of 30-50% after atd discontinuation. conflicting data have been reported with regard to the usefulness of adding thyroxine (i-t4) during and after atd treatment. also, clinicians are still in search of useful factors to predict remission/recurrence after atd withdrawal. eighty two consecutive patients were treated with atd for 15 months, combined with 12 months of i-t4. then, patients were randomized (p ... | 2000 | 11068483 |
| genetic analysis of bacteriophage-encoded cochaperonins. | early genetic studies identified the escherichia coli groes and groel genes because mutations in them blocked the growth of bacteriophages lambda and t4. subsequent genetic and biochemical analyses have shown that groes and groel constitute a chaperonin machine, absolutely essential for e. coli growth, because it is needed for the correct folding of many of its proteins. in spite of very little sequence identity to groes, the bacteriophage t4-encoded gp31 protein and the bacteriophage rb49-encod ... | 2000 | 11092834 |
| accelerated growth signals and low tumor-infiltrating lymphocyte levels predict poor outcome in t4 esophageal squamous cell carcinoma. | little is known about the biological nature of t4 esophageal carcinoma growth signals and host defenses. | 2000 | 11093500 |
| effect of combined treatment with calcitonin on bone densitometry of patients with treated hypothyroidism. | thyroid hormones (th) may affect bone metabolism and turnover, inducing a loss of bone mass among hyperthyroid and in hypothyroid patients under hormone replacement treatment. thyroid dysfunction leads to changes in the dynamics of parathyroid hormone (pth) and calcitonin (ct) secretion. | 2000 | 11022359 |
| exhaustive mutagenesis in silico: multicoordinate free energy calculations on proteins and peptides. | we have extended and applied a multicoordinate free energy method, chemical monte carlo/molecular dynamics (cmc/md), to calculate the relative free energies of different amino acid side-chains. cmc/md allows the calculation of the relative free energies for many chemical species from a single free energy calculation. we have previously shown its utility in host:guest chemistry (pitera and kollman, j am chem soc 1998;120:7557-7567)1 and ligand design (eriksson et al., j med chem 1999;42:868-881)2 ... | 2000 | 11025549 |
| is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? | several recent publications have drawn attention to the role of the thyroid hormone status of the mother on the future neuropsychological development of the child. the screening of pregnant women for clinical or subclinical hypothyroidism based on second trimester elevated maternal tsh values has been proposed. here, we have summarized present epidemiological and experimental evidence strongly suggesting that conditions resulting in first trimester hypothyroxinemia (a low for gestational age cir ... | 2000 | 11095417 |
| a characteristic serpin cleavage product of thyroxine-binding globulin appears in sepsis sera. | t4-binding globulin (tbg), the principal thyroid hormone-binding protein of serum, is a member of the serine protease inhibitor (serpin) superfamily. we report a characteristic serpin cleavage product of tbg in sepsis sera. at 49-50 kda, the tbg remnant is 4-5 kda smaller than the intact protein and is the same molecular mass as a tbg cleavage product produced by incubation with polymorphonuclear elastase. incubation with polymorphonuclear leukocytes also produces the 49- to 50-kda remnant, and ... | 2000 | 11095421 |
| persistent increase in bone turnover in graves' patients with subclinical hyperthyroidism. | hyperthyroid patients exhibit accelerated bone loss by increased bone turnover, and normalization of thyroid function is associated with a significant attenuation of increased bone turnover, followed by an increase in bone mineral density. however, of patients with graves' disease (gd) maintained on antithyroid drug (atd) treatment, some exhibit persistent suppression of tsh long after normalization of their serum free t3 (ft3) and free t4 (ft4) levels. the aim of this study was to examine wheth ... | 2000 | 11095447 |
| the effect of droloxifene and estrogen on thyroid function in postmenopausal women. | estrogen is known to increase serum t4-binding globulin (tbg) concentrations, thereby increasing serum total t4 concentrations. serum free t4 concentrations, however, remain normal. tamoxifen, a selective estrogen receptor modifier (serm), also raises serum tbg concentrations, but whether newer serms with less stimulatory action on the endometrium do so is not known. we, therefore, compared the effect of droloxifene, a serm, and conjugated equine estrogen on pituitary-thyroid function in normal ... | 2000 | 11095487 |
| nucleotide-sequence-specific and non-specific interactions of t4 dna polymerase with its own mrna. | the dna-binding dna polymerase (gp43) of phage t4 is also an rna-binding protein that represses translation of its own mrna. previous studies implicated two segments of the untranslated 5'-leader of the mrna in repressor binding, an rna hairpin structure and the adjacent rna to the 3' side, which contains the shine-dalgarno sequence. here, we show by in vitro gp43-rna binding assays that both translated and untranslated segments of the mrna contribute to the high affinity of gp43 to its mrna tar ... | 2000 | 11095675 |
| thyroid hormone stimulates na, k-atpase gene expression in the hemodynamically unloaded heterotopically transplanted rat heart. | regulation of myocardial na, k-atpase gene expression by thyroid hormone was investigated in the heterotopically transplanted rat heart to distinguish the direct effects of the hormone on the heart from effects secondary to increased hemodynamic workload. in this model, the transplanted heart is histologically normal and spontaneously beating, but hemodynamically unloaded. three days after transplantation, relative contents of ventricular na, k-atpase alpha2- and beta1-mrnas and alpha1- and alph ... | 2000 | 11041452 |
| [role of lymph nodes in rectal carcinoma]. | the significance of the lymph nodes for the therapy and the prognostics of the rectal cancer are reviewed. not only the depth of penetrations, but the probability of lymph node involvement (in our series tumors staged t1 had in 12% positive lymph nodes, t2 in 20% respectively, t3 in 37% and t4 in 80%) determine the possible surgical treatment. the available data of different techniques in lymphadenectomy and lymph node staging are compared and discussed. the aim of this paper is to give the onco ... | 2000 | 11098582 |
| nmr structure of oxidized glutaredoxin 3 from escherichia coli. | a high precision nmr structure of oxidized glutaredoxin 3 [c65y] from escherichia coli has been determined. the conformation of the active site including the disulphide bridge is highly similar to those in glutaredoxins from pig liver and t4 phage. a comparison with the previously determined structure of glutaredoxin 3 [c14s, c65y] in a complex with glutathione reveals conformational changes between the free and substrate-bound form which includes the sidechain of the conserved, active site tyro ... | 2000 | 11031118 |
| effects of amplification facilitators on diagnostic pcr in the presence of blood, feces, and meat. | the full potential of diagnostic pcr is limited, in part, by the presence of inhibitors in complex biological samples that reduce the amplification efficiency. therefore, different pre-pcr treatments are being used to reduce the effects of pcr inhibitors. the aim of the present study was to investigate the effects of 16 amplification facilitators to enhance dna amplification in the presence of blood, feces, or meat. different concentrations of amplification facilitators and inhibitory samples we ... | 2000 | 11101581 |
| [significance of neoadjuvant chemotherapy for gastric cancer]. | neoadjuvant chemotherapy for high-risk patients with advanced gastric cancer is important to increase the chance for curative resection and make unresectable gastric cancer tumors resectable by down-staging of the tumor. tumors with h0, p0, t3, t4, or n3 are the best candidates for this therapy. randomized controlled phase iii studies are needed in conjunction with accurate staging of the disease by laparoscopy. the results of histopathologic evaluation of resected materials following preoperati ... | 2000 | 11103233 |
| the structure of udp-n-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. | bacterial udp-n-acetylglucosamine 2-epimerase catalyzes the reversible epimerization at c-2 of udp-n-acetylglucosamine (udp-glcnac) and thereby provides bacteria with udp-n-acetylmannosamine (udp-mannac), the activated donor of mannac residues. mannac is critical for several processes in bacteria, including formation of the antiphagocytic capsular polysaccharide of pathogens such as streptococcus pneumoniae types 19f and 19a. we have determined the x-ray structure (2.5 a) of udp-glcnac 2-epimera ... | 2000 | 11106477 |
| the role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase. | human type 2 iodothyronine deiodinase (hd2) catalyzes the activation of t4 to t3. d2, like types 1 and 3 deiodinases, contains selenocysteine (sec) in the highly conserved active center at position 133. to evaluate the contribution of sec133 to the catalytic properties of hd2, we generated mutants in which cysteine (cys) or alanine (ala) replaced sec133. the km (t4) of cys133d2 was 2.1 microm, strikingly higher than that of native d2 (1.4 nm). in contrast, the relative turnover number was 10-fol ... | 2000 | 11108274 |
| [therapy concept in differentiated thyroid gland carcinoma--results of 25 years with 257 patients]. | differentiated thyroid carcinoma is a unique tumour in that a low risk-patient population with a tumour-related death rate of near 0% can be found. yet in these patients the risk and risk factors of curable recurrences must be considered. the question therefore arises, whether in defined subgroups of low risk-patients a reduced extent of treatment (hemithyroidectomy, total thyroidectomy without 131i ablation) may result in cure without recurrence, including low morbidity of treatment and reduced ... | 2000 | 11109916 |
| evaluation of the validity of the 1997 international union against cancer tnm classification of major salivary gland carcinoma. | the tnm classification (international union against cancer) of salivary gland carcinoma was revised in 1997. in this study, the authors have evaluated the validity of this new tnm classification and clinical staging in 1683 patients with parotid gland carcinoma. | 2000 | 11042558 |
| nuclear morphometry for the prediction of regional lymph nodes metastases in patients with cancer of the larynx. | the changes in cell nuclei reflect their activity. quantitative morphometric analyses of tumor nuclei could be instrumental in providing prognostic information. we studied whether, and if so, which specific nuclear parameters and histoclinical factors in patients with cancer of the larynx could be related to the lymph node metastases. specimens were taken from 61 patients surgically treated in the department of otolaryngology, jagiellonian university, cracow, poland, between 1987 and 1988. the p ... | 2000 | 11112977 |
| role of presympathetic c1 neurons in the sympatholytic and hypotensive effects of clonidine in rats. | the rostral ventrolateral medulla (rvlm) may play an important role in the sympatholytic and hypotensive effects of clonidine. the present study examined which type of presympathetic rvlm neuron is inhibited by clonidine, and whether the adrenergic presympathetic rvlm neurons are essential for clonidine-induced sympathoinhibition. in chloralose-anesthetized and ventilated rats, clonidine (10 microg/kg iv) decreased arterial pressure (116 +/- 6 to 84 +/- 2 mmhg) and splanchnic nerve activity (93 ... | 2000 | 11049859 |
| k-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors. | adenocarcinoma of the pancreas is likely to spread into the nerve plexuses around the superior mesenteric artery (sma) at a microscopic level. since there has been no detailed report on how minute cancer invasion is distributed among the peri-sma plexuses or which cases are more vulnerable to such an event, it has long been controversial how to treat this area when resecting the pancreatic head cancer. | 2000 | 11115351 |
| ct or eus for the initial staging of esophageal cancer? a cost minimization analysis. | patients with advanced (t4 and/or m1) esophageal cancer are offered palliative therapy. computed tomography (ct) is sensitive for distant metastases but is less sensitive than endosonography for t4 disease and celiac lymphadenopathy. the aim of this study was to determine whether initial ct or endosonography costs less to diagnose advanced esophageal cancer. | 2000 | 11115901 |
| thyroid hormones and their effects: a new perspective. | the thyroid hormones are very hydrophobic and those that exhibit biological activity are 3',5',3,5-l-tetraiodothyronine (t4), 3',5,3-l-triiodothyronine (t3), 3',5',3-l-triiodothyronine (rt3) and 3,5',-l-diiothyronine (3,5-t2). at physiological ph, dissociation of the phenolic -oh group of these iodothyronines is an important determinant of their physical chemistry that impacts on their biological effects. when non-ionized these iodothyronines are strongly amphipathic. it is proposed that iodothy ... | 2000 | 11117200 |
| successful withdrawal of thyroid hormone therapy in nursing home patients. | studies of community-dwelling patients have indicated that substantial numbers of patients might have had thyroid hormone therapy prescribed inappropriately and that thyroid hormone therapy in some can be discontinued without adverse effects or evidence of clinical hypothyroidism. we wanted to find out whether thyroid hormone therapy in selected nursing home patients could be withdrawn without adverse effect. | 2000 | 11117336 |
| allelic deletions of cell growth regulators during progression of bladder cancer. | cell growth regulators include proteins of the p53 pathway encoded by the genes cdkn2a (p16, p14arf), mdm2, tp53, and cdkn1a (p21) as well as proteins encoded by genes like rb1, e2f, and mycl. in the present study we investigated allelic deletions of all these genes in each recurrent bladder tumor from well-defined clinical material with more than 3 years of follow-up. we followed three groups (22 or 23 patients/group) of patients with: (a) recurrent noninvasive tumors (ta); (b) primary muscle-i ... | 2000 | 11118045 |
| changes in serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs receiving phenobarbital for one year. | a multicentric prospective study was conducted to monitor the effect of phenobarbital on serum total thyroxine (t4) and thyroid-stimulating hormone (tsh) concentrations in epileptic dogs. serum t4 concentrations were determined for 22 epileptic dogs prior to initiation of phenobarbital therapy (time 0), and 3 weeks, 6 months, and 12 months after the start of phenobarbital. median t4 concentration was significantly lower at 3 weeks and 6 months compared to time 0. thirty-two percent of dogs had t ... | 2000 | 11126325 |
| reduced ligation during dna base excision repair supported by brca2 mutant cells. | the breast cancer predisposing genes brca1 and brca2 appear to be involved in dna repair. in particular, the sensitivity of brca2-deficient mouse embryonic fibroblasts to ionizing radiation and the demonstrated interaction of the brca2 protein with rad51, a major factor in recombinational repair, indicate that brca2 is important for double strand break repair. the human brca2-deficient human cell line capan-1, whilst being sensitive to ionizing radiation, is also sensitive to the alkylating agen ... | 2000 | 11126365 |
| assessment of sex hormone-binding globulin and osteocalcin in patients undergoing coronary artery bypass graft surgery. | to determine sex hormone-binding globulin (shbg) and osteocalcin (oc) levels in patients undergoing coronary artery bypass graft surgery to clarify the status of peripheral thyroid metabolism and to correlate shbg and oc with thyroid hormones and adverse postoperative events. | 2000 | 11052436 |
| the auditory threshold in a school-age population is related to iodine intake and thyroid function. | the aim of this study was to determine the relationship between auditory capacity and urinary iodine, taking into account thyroid volume and function, in a population of school-age children. audiometry was carried out in 150 children (ages 6-14 years), together with measurements of thyroid volume, thyrotropin (tsh), free t3, free t4, thyroglobulin, antiperoxidase and anti-tsh receptor antibodies, as well as iodine in a casual urine sample. children with a tsh >5 microu/ml were excluded from the ... | 2000 | 11128728 |
| prognostic value of lymph node involvement in oral cancers: a study of 137 cases. | the aim of this study was to assess the prognostic value of lymph node involvement in patients with squamous cell carcinoma of the oral cavity. | 2000 | 11129021 |
| preoperative staging of rectal cancer with mri: accuracy and clinical usefulness. | preoperative staging is essential for planning of optimal therapy for patients with rectal cancer. recently, magnetic resonance imaging (mri) is used frequently because of its benefits of clear pelvic image are better than other diagnostic methods. the purpose of this study was to determine accuracy rates and clinical usefulness of mri in preoperative staging of rectal cancer. | 2000 | 11129420 |
| the effect of atrazine on puberty in male wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. | since atrazine (atr), a chlorotriazine herbicide, has been shown previously to alter the secretion of luteinizing hormone (lh) and prolactin (prl) through a direct effect on the central nervous system (cns), we hypothesized that exposure to atr in the edstac male pubertal protocol (juvenile to peripubertal) would alter the development of the male rat reproductive system. we dosed intact male wistar rats from postnatal day (pnd) 23 to 53 and examined several reproductive endpoints. atr (0, 12.5, ... | 2000 | 11053540 |
| myxedema coma: diagnosis and treatment. | myxedema coma, the extreme manifestation of hypothyroidism, is an uncommon but potentially lethal condition. patients with hypothyroidism may exhibit a number of physiologic alterations to compensate for the lack of thyroid hormone. if these homeostatic mechanisms are overwhelmed by factors such as infection, the patient may decompensate into myxedema coma. patients with hypothyroidism typically have a history of fatigue, weight gain, constipation and cold intolerance. physicians should include ... | 2000 | 11130234 |
| vasoactive intestinal polypeptide in rat heart atria: the effect of hyperthyroidism. | the effects of transient and sustained hyperthyroidism on vasoactive intestinal polypeptide-like immunoreactivity (vip-li) levels were studied in the heart atria of developing and adult rats. newborn rats were divided into 5 groups. neo-t animals were treated with thyroxine (t4) during postnatal days 1-8 and sacrificed at the age of 60 days. neo-s rats were treated with t4 during postnatal days 1-60 and sacrificed one day later. adult-1 and adult-2 animals received t4 during days 52-60 and were ... | 2000 | 11072802 |
| radiology of the retropharyngeal space. | the retropharyngeal space extends from the skull base to the t4 vertebral level and contains the retropharyngeal nodes superiorly and fatty tissue elsewhere. this space is important as it is a potential route for the spread of infection and malignancy. this pictorial essay outlines the anatomy of the retropharyngeal space and illustrates the various disease processes that may be seen in region.chong, v. f. h., fan, y. f. (2000). clinical radiology55, 740-748. | 2000 | 11052873 |
| self-cleavage of p2sp1 rna with mg2+ and non-ionic detergent (brij 58). | the precursor of an rna molecule from t4-infected e. coli cells (p2sp1 rna) has the capacity to cleave itself at specific positions [(upa (139-140) and cpa (170-171)], within a putative loop and stem structure. this sequence-specific cleavage requires at least a monovalent cation and non-ionic detergents. we studied the self-cleavage reaction of an rna fragment (guuucguacaaac) (r1) with the sequence corresponding to the p2sp1 rna in the presence of mg2+ and non-ionic detergents. it requires mg2+ ... | 2000 | 11132630 |
| effect of short-term feed restriction and calorie source on hormonal and metabolic responses in geldings receiving a small meal. | the metabolic effects of short-term feed restriction and dietary calorie source were studied in horses receiving high-roughage or high-concentrate diets. four thoroughbred geldings were assigned to four treatment groups in a 4 x 4 latin square experiment. the four treatments were 1) a nutritionally adequate high-roughage ration (70% roughage, 30% concentrate; ahr), 2) a nutritionally adequate high-concentrate ration (40% roughage, 60% concentrate; ahc), 3) 70% of the intake of the ahr diet (rhr) ... | 2000 | 11132825 |
| comparison of two different anesthesia regimens in patients undergoing aortocoronary bypass grafting surgery: sufentanil-midazolam versus remifentanil-propofol. | to compare intraoperative hemodynamics and depth of anesthesia using sufentanil-midazolam (sm) versus remifentanil-propofol (rp) anesthesia. | 2000 | 10972607 |
| neuro-cognitive activity during a self-paced visuospatial task: comparative eeg profiles in marksmen and novice shooters. | log-transformed eeg power spectral estimates (6-7, 9,10-11,18-22, and 36-44 hz), obtained from skilled marksmen and novice shooters at sites f3, f4, c3, c4,t3, t4, p3, p4, o1, and o2 during the aiming period (6 s) of a target shooting task for each of 40 trials up to the moment of trigger pull, were contrasted to determine regional differences in cortical activation. the eeg power obtained from both groups during the preparatory aiming period was also compared to that observed for a similar time ... | 2000 | 10967230 |
| clinical staging of esophageal carcinoma. ct, eus, and pet. | ct is readily available to all patients. it is relatively inexpensive and fees are usually reimbursed. it provides exquisite anatomic detail of the chest and abdomen in patients with esophageal cancer. the only reliable use of ct in the determination of t is the exclusion of t4 tumors, which is suggested by the preservation of fat planes. enlarged lymph nodes are suspicious for metastatic disease but require further study or tissue sampling if nodal metastases will determine treatment. its major ... | 2000 | 10967751 |
| expression of insulin-like growth factor binding proteins (igfbps) before and during the hormone sensitive period of adipose tissue development in the fetal pig. | the present study examined the influence of fetal age and thyroxine (t4) and growth hormone (gh) treatment, on the expression of insulin-like growth factor binding proteins (igfbps) in fetal pigs. on day 70 of gestation fetuses were either hypophysectomized (hypox), hypox and implanted with t4 pellets, or left intact, and were recovered 5, 10, 15 and 20 days following hypox and t4 pellet placement. intact fetuses were also recovered from several dams at 50 days of gestation. in additional dams, ... | 2000 | 10969885 |
| glycosyltransferase structure and mechanism. | the high-resolution x-ray crystal structures of a new form of bacteriophage t4 beta-glucosyltransferase, escherichia coli murg, bacillus subtilis spsa, bovine beta-1,4-galactosyltransferase 1 and rabbit n-acetylglucosaminyltransferase i have now been solved. these glycosyltransferase structures have provided the first detailed view of the structural basis of catalysis, as well as new insight into glycosyltransferase classification. | 2000 | 11042447 |
| structure and folding of bacteriophage t4 gene product 9 triggering infection. ii. study of conformational changes of gene product 9 mutants using monoclonal antibodies. | gene product 9 (gp9) of bacteriophage t4, whose spatial structure we have recently solved to 2.3 a resolution, is a convenient model for studying the folding and oligomerization mechanisms of complex proteins. the gp9 polypeptide chain consists of 288 amino acids forming three domains. three monomers, packed in parallel, assemble to a functionally active protein. the main aim of this work was to study conformational changes and trimerization of gp9 deletion mutants using monoclonal antibodies (m ... | 2000 | 11042500 |
| modeling protein-small molecule interactions: structure and thermodynamics of noble gases binding in a cavity in mutant phage t4 lysozyme l99a. | the complexes of phage t4 lysozyme l99a with noble gases have been studied by molecular dynamics simulation. in a long simulation of the complex with one xe atom, the structure was found to undergo global conformation change involving a reversible opening and closing of the entrance to the substrate-binding site, during which the conformations of the n and c-terminal domains varied little. the distributions of xe positions sampled in dynamics simulations were refined in terms of anisotropic gaus ... | 2000 | 10993736 |
| masses of the tongue and floor of the mouth: findings on magnetic resonance imaging. | the purpose of this study was to determine the value of mr imaging for the demonstration of masses in the tongue and floor of the mouth. nine patients were prospectively examined with mr imaging after physical examination. imaging protocol included t2 and contrast-enhanced and non-contrast-enhanced t1-weighted turbo spin-echo sequences, and the findings were compared with surgical and histopathological results. histopathological examination revealed four squamous cell carcinomas, one adenoid cys ... | 2000 | 11044946 |
| severity of hyperemesis gravidarum correlates with serum levels of reverse t3. | to investigate the possible physiological relevance of extra-thyroidal production of reverse t3 (rt3) in hyperemesis gravidarum, measurements of serum rt3, free t3 (ft3), free t4, (ft4), and nonesterified fatty acids (nefa) were correlated with weight loss of hyperemetic women. all the thyroid hormones, nefas and weight loss were significantly higher in hyperemesis gravidarum than in control subjects, and also higher than in those with milder symptoms of morning sickness (p < 0.05). elevations o ... | 2000 | 11045323 |
| [evaluation of new tnm classification for lung cancer, especially t3n0m0, stage iiia, stage iiib, and pm]. | the purpose of this study was to evaluate the results of new tnm staging system for lung cancer in 1997, especially t3n0m0, stage iiia, stage iiib, and pm. five-year survival rates of the patients with stage iiia and stage iiib were 16% and 18% respectively (ns). five-year survival rates of patients with t3n1m0, t1n2m0, t2n2m0, and t3n2m0 were 40%, 28%, 15%, and 3%, respectively. the prognosis of t3n2m0 was significantly worse than that of t3n1m0, t1n2m0, and t2n2m0. five-year survival rates of ... | 2000 | 11048439 |
| [inverted papilloma of the nose and paranasal sinuses. long-term outcome of endoscopic endonasal resection]. | there is still some skepticism about endoscopic endonasal resection of inverted papillomas. we conducted a long-term retrospective study and examined 104 patients (82 male, 22 female) with inverted papilloma who were operated at the ent-department of the university of erlangen between 1974 and 1997. the endoscopic approach was chosen in each case, either alone or in combination with external approaches. in 64.4% (67 cases), tumors of all t-classes were resected by endoscopic approach alone (t1:1 ... | 2000 | 10994167 |
| [the validity and problems of a new staging system for lung cancer from the point of view of surgical results]. | the validity and problems of the new staging system for resected lung cancer were assessed. in the new staging system for primary lung cancer, stage i is divided into two groups (a and b) on the basis of the tumor diameter. the boundary is 30 mm in maximum diameter of the tumor. on the other hand, intrapulmonary satellite nodules in the resected lung (pm1) are considered as t4. this means that a patient with pm1 is classified as stage iiib or iv. the five-year cumulative survival rates of 191 co ... | 2000 | 11048444 |
| atrial natriuretic peptide and thyroid hormones' relation to plasma and heart calcium and magnesium concentrations of wistar rats exposed to cold and hot ambients. | plasma anp (atrial natriuretic peptide), thyroid hormones, and calcium and magnesium levels as well as heart tissue calcium and magnesium concentrations were determined in male wistar rats after exposure of 114 rats at low temperature (4 degrees c) and 95 rats at high temperature (35-36 degrees c) for 28 d. plasma anp, triiodothyronine (t3), thyroxine (t4), thyroid-stimulating hormone (tsh), free t3, and free t4 were estimated by radioimmunoassay, and plasma and heart tissue levels of ca and mg ... | 2000 | 11049208 |
| effects of anesthesia, surgery, and intravenous administration of fluids on plasma antidiuretic hormone concentrations in healthy dogs. | to evaluate effects of anesthesia, surgery, and intravenous administration of fluids on plasma concentrations of antidiuretic hormone (adh), concentration of total solids (ts), pcv, arterial blood pressure (bp), plasma osmolality, and urine output in healthy dogs. | 2000 | 11039560 |
| hypopharyngeal squamous cell carcinoma--treatment results in 138 consecutively admitted patients. | the aim of this study was to evaluate the results of the initial and salvage treatment for hypopharyngeal carcinoma. the study was conducted in 1963 to 1991 and included 138 patients (38 females (28%) and 100 males (73%)). most of the tumours originated in the piriform sinus (86%). tumour stage distribution was t1: 20%, t2: 27%, t3: 37% and t4: 17% and nodal stage distribution was n0: 45%, n1: 25%, n2: 10%, and n3: 20%. primary treatment was delivered with curative intent in 124 out of 138 cases ... | 2000 | 11041117 |
| size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage t4 lysozyme. | to investigate the relative importance of size and polarizability in ligand binding within proteins, we have determined the crystal structures of pseudo wild-type and cavity-containing mutant phage t4 lysozymes in the presence of argon, krypton, and xenon. these proteins provide a representative sample of predominantly apolar cavities of varying size and shape. even though the volumes of these cavities range up to the equivalent of five xenon atoms, the noble gases bind preferentially at highly ... | 2000 | 10993735 |
| changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment. | the aim of this prospective, follow-up study was to examine the influence of overt hypothyroidism (ohp) and subclinical (shp), before and during thyroxine (t4) treatment, on lipoprotein(a) [lp(a)], other lipoproteins, and apolipoproteins. twenty-four patients (17 females, 7 males) with ohp, aged 54 +/- 11.1 years (group a) and 23 patients (females) with shp aged 50.1 +/- 13.2 years (group b) were evaluated and compared to 34 and 38 controls, respectively. all patients received t4 therapy in a st ... | 2000 | 11041458 |
| dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. | biological effects of genistein are currently under investigation by the national toxicology program because of widespread and increasing soy consumption by humans and evidence for modulation of endocrine function. rats were exposed to genistein aglycone in soy-free feed fortified at 0, 5, 100, and 500 ppm starting in utero through 20 weeks. thyroid glands and serum were analyzed for total genistein (aglycone + conjugates) using hplc with electrospray mass spectrometric detection. microsomal thy ... | 2000 | 11042097 |
| studies on thyroid function in rats subjected to repeated oral administration with kojic acid. | to elucidate the effects of kojic acid on thyroid function, the compound was given orally to male rats for 4 weeks at 0, 4, 15, 62.5, 250 and 1,000 mg/kg. in 1,000 mg/kg treatment of kojic acid, the rats showed a slight decrease in motility, inhibition of body weight gain, and a decrease in food consumption. an increase in thyroid weight and a morphological change, i.e., hypertrophy of epithelial cells of the thyroid gland follicles, were observed after 1 week of administration. in addition, the ... | 2000 | 10987123 |
| bilateral open treatment of spontaneous pneumothorax: a new access. | a new technique for bilateral apical bullectomy and pleurectomy via axillary minithoracotomy and transmediastinal access to the contralateral side, was used in 13 patients with bilateral apical blebs and/or pneumothorax. the contralateral space is reached at the posterior superior mediastinum, passing between the first thoracic vertebral bodies (t1-t4) and the oesophagus. the contralateral lung apex is then pulled into the thoracotomy side and apical bullectomy carried out by linear stapler. the ... | 2000 | 11053826 |
| clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. | the objective of our study was to estimate the expected change in serum lipoprotein concentrations after treatment with t4 in patients with mild thyroid failure (i.e. subclinical hypothyroidism). our data sources included medline, between january 1966 and may 1999, and review of references from relevant articles. there were 1,786 published studies identified, 461 abstracts reviewed, 74 articles retrieved, 24 articles evaluated against predetermined entry criteria, and 13 studies systematically r ... | 2000 | 10999775 |
| reversion of arge3 ochre strain escherichia coli ab1157 as a tool for studying the stationary-phase (adaptive) mutations. | adaptive (starvation-associated) mutations occur in non-dividing cells and allow growth under the selective conditions imposed. we developed a new method for the determination of adaptive mutations in escherichia coli. the system involves reversion to prototrophy of the arge3oc mutation and was tested on ab1157 strains mutated in the mutt and/or muty genes. the bacteria that mutated adaptively grow into colonies on minimal medium plates devoid of arginine (starvation conditions) when incubated l ... | 2000 | 11051211 |
| esophageal dilation for endosonographic evaluation of malignant esophageal strictures is safe and effective. | endoscopic ultrasound (eus) is accepted as the most accurate modality for t- and n-staging of esophageal cancer, but some malignant strictures prevent passage of the echoendoscope beyond the level of the tumor. this incomplete evaluation may decrease staging accuracy. previous studies have yielded conflicting results regarding the safety and efficacy of esophageal dilation for eus. | 2000 | 11051353 |
| [conservative treatment of adenocarcinomas of the anorectal junction by preoperative radiotherapy and intersphincteral resection]. | adenocarcinomas of the anorectal junction, especially t3 lesions, are usually treated by abdominoperineal resection. the aim of this study was to evaluate oncologic and functional results following conservative radiosurgical treatment of cancers of the anorectal junction. | 2000 | 11051690 |
| the lectin domain of udp-n-acetyl-d-galactosamine: polypeptide n-acetylgalactosaminyltransferase-t4 directs its glycopeptide specificities. | the initiation step of mucin-type o-glycosylation is controlled by a large family of homologous udp-galnac:polypeptide n-acetylgalactosaminyltransferases (galnac-transferases). differences in kinetic properties, substrate specificities, and expression patterns of these isoenzymes provide for differential regulation of o-glycan attachment sites and density. recently, it has emerged that some galnac-transferase isoforms in vitro selectively function with partially galnac o-glycosylated acceptor pe ... | 2000 | 10984485 |
| thyroid function and intellectual development of infants nursed by mothers taking methimazole. | for many years, breast-feeding was forbidden if antithyroid drugs were being used. recently, limited studies have shown the relative safety of propylthiouracil and methimazole (mmi). it is not known whether mmi therapy of lactating mothers for 1 yr is safe for breast-fed infants and does not cause alterations in thyroid function and intellectual development. between 1988 and 1998, 139 thyrotoxic lactating mothers and their infants were studied. fifty-one thyrotoxic lactating mothers were treated ... | 2000 | 10999814 |
| drug therapy for hyperthyroidism in pregnancy: safety issues for mother and fetus. | hyperthyroidism (thyrotoxicosis) in pregnancy and the child bearing years is usually attributable to graves' disease. this is an autoimmune condition in which thyroid-stimulating immunoglobulins (tsi) cause hyperthyroidism. as a rule, pregnancy complicates the management of hyperthyroidism, rather than vice versa. however, patients who remain thyrotoxic during pregnancy are at increased risk of maternal and fetal complications, particularly miscarriage and stillbirth. therefore, bodyweight loss, ... | 2000 | 11005705 |
| reevaluation of nonphytate phosphorus requirement of growing pullets with and without phytase. | an experiment was conducted to re-evaluate the nonphytate phosphorus (npp) requirement of growing pullets and to determine to what extent this requirement could be reduced by phytase. six diets in a 3 x 2 factorial design were used. the pullets of the control group (t1) were fed a sequence of 0.4-0.35-0.3% npp for the age periods of 0 to 6, 6 to 12, and 12 to 18 wk, respectively, according to nrc (1994) recommendation. the npp level was reduced by an increment of 0.1% in each phase in t2 and t3. ... | 2000 | 10947183 |
| [the value of spiral ct in the staging of carcinomas of the oral cavity and of the oro- and hypopharynx]. | to compare spiral and conventional ct in the staging of carcinomas of the oral cavity, the oropharynx and hypopharynx. | 2000 | 10955294 |
| effect of subclinical hypothyroidism on body fluid compartments. | the present study was aimed to assess the effects of subclinical hypothyroidism on body composition (bc). | 2000 | 11014384 |
| thermodynamic and structural studies of cavity formation in proteins suggest that loss of packing interactions rather than the hydrophobic effect dominates the observed energetics. | the hydrophobic effect is widely believed to be an important determinant of protein stability. however, it is difficult to obtain unambiguous experimental estimates of the contribution of the hydrophobic driving force to the overall free energy of folding. thermodynamic and structural studies of large to small substitutions in proteins are the most direct method of measuring this contribution. we have substituted the buried residue phe8 in rnase s with alanine, methionine, and norleucine. bindin ... | 2000 | 11015216 |
| impact of lead exposure on pituitary-thyroid axis in humans. | thyroid function tests (serum levels of thyroxine-t4, triiodothyronine-t3 and thyroid stimulating hormone-tsh) were performed in fifty-eight men (mean age: 31.7 +/- 10.6 years; mean duration of lead exposure: 156.9 +/- 122.7 months). these subjects were exposed to lead either as petrol pump workers or automobile mechanics. the mean whole blood lead (pb-b) levels were 2.49 +/- 0.45 micromole/l (51.90 +/- 9.40 microg/dl) in the lead exposed workers and were approximately 5 times higher than in the ... | 2000 | 11016408 |
| radical surgery for gallbladder cancer: current options. | gallbladder carcinoma is the most common malignancy of the biliary tract. there are still many controversies regarding the type of curative surgical treatment for each stage of the disease. the staging system used is the tnm classification of the international union against cancer. different patterns of spread characterize gallbladder cancer but the two main types are direct invasion and lymph node metastases; since only the depth of invasion can be easily recognized by imaging techniques, it be ... | 2000 | 11016462 |
| the success rate of identification of the sentinel lymph node in breast cancer: our training series. | a new phase of breast conserving surgery has started very recently, aimed at eliminating axillary dissection in node-negative patients by using the sentinel lymph node (sn) technique. between november 1998 and january 2000 we performed 151 operations for breast cancer on 145 patients. we performed axillary lymphoscintigraphy using 99tc-labeled human serum albumin microcolloidal particles injected subdermally in 50 patients who met our selection criteria. in this series we focused on the success ... | 2000 | 11016712 |
| cisplatin-epirubicin-paclitaxel weekly administration with g-csf support in advanced breast cancer. a southern italy cooperative oncology group (sicog) phase ii study. | it has been shown in vitro that both cisplatin and epirubicin increase the antitumor activity of paclitaxel. weekly administration could give a substantial improvement in the therapeutic index of cisplatin and paclitaxel. this study was aimed at defining the antitumor activity of a weekly cisplatin-epirubicin-paclitaxel (pet) administration in locally advanced or metastatic breast cancer patients. | 2000 | 11016746 |