Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| relationships between force-feeding and some physiological parameters in geese bred for fatty liver. | the susceptibility of geese of different genotypes and sexes to force-feeding, some plasma biochemical parameters (thyroid hormones, cholesterol, retinoids, total protein and albumin) of force-fed geese, and the relationship between force-feeding, fat storage and the above-mentioned parameters were studied. sixty (30 male and 30 female) geese of three genotypes (hungarian, landes and their crossbred called babat hybrid) were divided in two groups at 12 weeks of age. geese in one group (5 males a ... | 2000 | 11402679 |
| near infrared spectrophotometry for the diagnosis of vasculogenic erectile dysfunction. | a specialized near infrared spectrophotometry instrument for noninvasive, continuous monitoring of the hemodynamic events of erection in the human penis has been developed. its potential application for the diagnostic evaluation of erectile dysfunction was investigated. thirty-eight patients and 18 volunteer subjects underwent penile near infrared spectrophotometry using an optical sensor probe with wavelength selectivity for hemoglobin absorption spectra. penile blood volume changes and their t ... | 2000 | 11424961 |
| [lumbar radical nephrectomy. a retrospective analysis of 186 cases]. | 186 cases of nephrectomy for renal cell cancer are studied retrospectively. the overall 5-year survival rate was 77.2%. according to the 4th edition of the "tnm" classification system of uicc the survival rates of patients with t2-(n = 97), t3a (n = 58) and t3b-tumors (n = 25) were 80.9%, 79.3% and 65.6%, respectively. no patient with a stage t4 tumor (n = 6) survived longer than 20 months. the 5-year survival rate of patients with n1-lymph node metastases was 83.3% (n = 8); without lymph node m ... | 2000 | 10768226 |
| clinical significance of autoimmune thyroid disease in myasthenia gravis. | we investigated thyroid function and autoimmunity in 74 (61% females) consecutive patients with mg. 30 of these patients were tested twice: the time between the investigations ranging from 1 to 4 years. mg was diagnosed on the basis of typical clinical symptoms, a positive tensilone-test, and/or detectable acetylcholine antibodies and/or repetetive stimulation tests. eye involvement was present in 86%, concurrent thymomas in 56%. the following parameters were measured in the serum of these patie ... | 2000 | 10768835 |
| metallothionein expression in transplantable mouse mammary tumors. | the metal binding protein, metallothionein (mt) is involved in various physiological processes. in various human tumors, moreover, mt is reported to play an important role in carcinogenesis. | 2000 | 10769683 |
| cervical coupling during lateral head translations creates an s-configuration. | to determine cervical coupling during the posture of lateral head translation relative to a fixed thoracic cage. | 2000 | 10771122 |
| developing chicken oligodendrocytes express the type iv oligodendrocyte marker t4-o in situ, but not in vitro. | accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. we recently reported that a polyclonal antiserum against an unknown antigen, the t4-o molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type iv variety of del rio hortega. the present study examines the developmental expression of the t4-o molecule in situ and in vitro. the results show that t4-o immunoreactive cells first appear at e15 in the vent ... | 2000 | 10771152 |
| [results of a survey of 549 patients regarding long-term clinical outcome and quality of life four years after ptca]. | quality control becomes increasingly important in interventional cardiology. since in most health care systems, clinical treatment of patients who underwent percutaneous transluminal coronary angioplasty (ptca) is left to general practitioners, important information on the clinical long-term outcome is lost for the cardiologic centers. aim of this study was to evaluate the clinical status of these patients 4 years after treatment with a ptca at our institution. | 2000 | 10771558 |
| the central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. | prolonged fasting is associated with a downregulation of the hypothalamo-pituitary thyroid (h-p-t) axis, which is reversed by administration of leptin. the hypothalamic melanocortin system regulates energy balance and mediates a number of central effects of leptin. in this study, we show that hypothalamic melanocortins can stimulate the thyroid axis and that their antagonist, agouti-related peptide (agrp), can inhibit it. intracerebroventricular (icv) administration of agrp (83-132) decreased pl ... | 2000 | 10749579 |
| azu-1: a candidate breast tumor suppressor and biomarker for tumor progression. | to identify genes misregulated in the final stages of breast carcinogenesis, we performed differential display to compare the gene expression patterns of the human tumorigenic mammary epithelial cells, hmt-3522-t4-2, with those of their immediate premalignant progenitors, hmt-3522-s2. we identified a novel gene, called anti-zuai-1 (azu-1), that was abundantly expressed in non- and premalignant cells and tissues but was appreciably reduced in breast tumor cell types and in primary tumors. the azu ... | 2000 | 10749935 |
| morphometric x-ray absorptiometry and morphometric radiography of the spine: a comparison of prevalent vertebral deformity identification. | prevalent vertebral deformities are associated with a substantially increased risk of subsequent vertebral and nonvertebral fractures. knowledge of vertebral fracture status is an important component in the prediction of further fractures in patients with osteoporosis. this study reports a comparison of the quantitative identification of vertebral deformities on morphometric x-ray absorptiometry (mxa) scans and conventional radiographs (mrx) in 161 postmenopausal women (mean age +/- sd, 64 +/- 7 ... | 2000 | 10750572 |
| combined resection of t4 lung cancer with invasion of the descending thoracic aorta. | 2000 | 10750808 | |
| dual thyroid ectopy: case report and review of the literature. | dual ectopic thyroid glands rarely occur, and only six cases have been reported in the literature. the authors describe a 14-year-boy who had a midline neck swelling for 8 to 9 years. the swelling increased gradually, but he had no pressure symptoms. the thyroid hormone profile showed a moderately increased thyroid-stimulating hormone value and normal t3 and t4 levels. a tc-99m sodium pertechnetate thyroid scan showed dual ectopic thyroid glands in the sublingual and subhyoid regions. | 2000 | 10750961 |
| [study on the p53 gene mutation and microsatellite instability of gastric carcinoma]. | to observe the relationship between p53 gene mutation and microsatellite instability (msi) of the preoperative staging of gastric carcinoma by endoscopic ultrasonography(eus). | 2000 | 10751531 |
| evidence for colorectal cancer micrometastases using reverse transcriptase-polymerase chain reaction analysis of muc2 in lymph nodes. | poor survival in patients following resection for early stage colorectal cancer is thought to be due in part to the presence of occult micrometastases at the time of surgery. the muc2 mucin gene is highly expressed in the colon and associated colorectal tumors and may be a candidate marker for colorectal cancer micrometastases. we have used rt-pcr to detect expression of muc2 mrna transcripts in order to identify possible lymph node micrometastases in node negative (stage i and ii, or dukes a an ... | 2000 | 10757125 |
| association of the antidiabetic effects of bromocriptine with a shift in the daily rhythm of monoamine metabolism within the suprachiasmatic nuclei of the syrian hamster. | bromocriptine, a dopamine d2 agonist, inhibits seasonal fattening and improves seasonal insulin resistance in syrian hamsters. alterations in daily rhythms of neuroendocrine activities are involved in the regulation of seasonal metabolic changes. changes in circadian neuroendocrine activities that regulate metabolism are believed to be modulated by central circadian oscillators within the hypothalamic suprachiasmatic nuclei (scn) of seasonal animals. we examined the association of metabolic resp ... | 2000 | 10757461 |
| comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty. | hypotensive epidural anaesthesia (hea) is a technique for reducing peroperative blood loss by significantly lowering mean arterial pressure (map). | 2000 | 10757582 |
| the use of carboplatin and paclitaxel with daily radiotherapy in patients with locally advanced squamous cell carcinomas of the head and neck. | unresectable squamous cell carcinomas of the head and neck (scchn) continue to pose a significant therapeutic challenge. this report defines the toxicities, efficacy, and prognostic factors associated with the combination of carboplatin (cbdca), paclitaxel, and once-daily radiation for patients with locally advanced disease. additionally, the pharmacokinetics of paclitaxel were investigated. | 2000 | 10758304 |
| surgery for t4 breast carcinoma: implications for local control. | despite increasing public awareness and widespread availability of mammography, many patients will present with locally advanced breast cancers. the role of surgery remains controversial. between 1993 and 1998, 47 of 393 (11.9%) breast cancer patients presented with t4 (inflammatory or locally advanced) carcinoma. we reviewed multimodality management, clinical response to neoadjuvant therapy, perioperative course and complications, and local control. forty-six women and one man were diagnosed wi ... | 2000 | 10759194 |
| missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. | previous studies on the rdw rat have suggested that its dwarfism is caused primarily by dysfunction of the thyroid gland. in this study, rat thyroid glands were analyzed endocrinologically and morphologically to clarify the primary cause of dwarfism in the rdw rat. the rdw rat showed lowered thyroid hormone (t4 and t3) levels but elevated tsh in serum. the rdw thyroid gland was almost proportional in size and it was not goiter in gross inspection. our histological investigation produced three re ... | 2000 | 10760744 |
| spinal subdural tuberculous abscess. | spinal subdural abscess is rare and only 48 cases have been described to date. in this report, we present an additional spinal subdural tuberculous abscess. | 2000 | 10762199 |
| supracricoid partial laryngectomy with cricohyoidoepiglottopexy and cricohyoidopexy for glottic and supraglottic carcinomas. | to review the patients operated in our department with supracricoid partial laryngectomy with either cricohyoidoepiglottopexy (chep) (59 cases) or cricohyoidopexy (chp) (10 cases) technique, for primary or recurrent glottosupraglottic squamous cell carcinoma and compare the technique with other surgical or conservative approaches for treatment of laryngeal carcinoma. | 2000 | 10764009 |
| multilevel thoracic pedicle aplasia causing congenital thoracic kyphosis: case report. | congenital thoracic kyphosis is a rare cause of treatable myelopathy. multilevel thoracic pedicle aplasia as a cause of this deformity has not been previously reported in the literature. we report a case and describe the surgical management and outcome. | 2000 | 10764276 |
| gonadotropin-releasing hormone stimulates thyroid activity in a freshwater murrel, channa gachua (ham.), and carps, catla catla (ham.) and cirrhinus mrigala (ham.). | injections of mammalian gnrh (mgnrh), salmon gnrh (sgnrh), and a homologous murrel, channa punctatus, gnrh (cgnrh) to a murrel, channa gachua, and a carp, catla catla, at a dose of 1 microg/250 g body wt significantly increased plasma thyroxine (t4) levels above control. piscine gnrhs (sgnrh and cgnrh) had significantly greater stimulatory effects compared with mgnrh. to observe whether this stimulatory effect by gnrhs is direct or indirect, thyroid follicles were isolated from hypobranchial mus ... | 2000 | 10764556 |
| endoribonuclease regb from bacteriophage t4 is necessary for the degradation of early but not middle or late mrnas. | the regb endoribonuclease from bacteriophage t4 cleaves early mrnas specifically in the middle of the sequence ggag. we show here that regb is required for the degradation of bulk t4 early mrna. in the absence of regb, the chemical half-life of early transcripts is increased nearly fourfold, whereas their functional half-life is increased twofold. regb also regulates the translation of several prereplicative genes. the synthesis of several early proteins is down-regulated, probably as a conseque ... | 2000 | 10764573 |
| treatment results of esophageal carcinoma of clinical t3, t4m0: historical comparison between neoadjuvant chemoradiotherapy followed by surgery or definitive radiotherapy and conventional surgery. | we investigated results for thoracic t3-t4 esophageal squamous cell carcinoma in two strategies. the protocol group (46 patients) consisted of neoadjuvant chemoradiotherapy (44 gy, cddp, 5-fu), followed by either definitive radiotherapy (total 70 gy) for responders or surgery for non-responders. the surgery group (26 patients) underwent esophagectomy with regional lymph node dissection. nineteen of them received postoperative radiotherapy. surgical candidates in both groups received intraoperati ... | 2000 | 10767370 |
| approaching the upper thoracic vertebrae without sternotomy or thoracotomy: a radiographic analysis with clinical application. | the distribution of the lowest vertebra tangential to the suprasternal notch and the lowest intervertebral disc visualized above the sternum was determined on magnetic resonance imaging (mri) studies. the method is illustrated in seven patients undergoing upper thoracic spinal reconstruction to define a surgical approach without sternotomy or thoracotomy. | 2000 | 10767801 |
| cysteines involved in radical generation and catalysis of class iii anaerobic ribonucleotide reductase. a protein engineering study of bacteriophage t4 nrdd. | class iii ribonucleotide reductase (rnr) is an anaerobic glycyl radical enzyme that catalyzes the reduction of ribonucleotides to deoxyribonucleotides. we have investigated the importance in the reaction mechanism of nine conserved cysteine residues in class iii rnr from bacteriophage t4. by using site-directed mutagenesis, we show that two of the cysteines, cys-79 and cys-290, are directly involved in the reaction mechanism. based on the positioning of these two residues in the active site regi ... | 2000 | 10748010 |
| allosteric regulation of the class iii anaerobic ribonucleotide reductase from bacteriophage t4. | ribonucleotide reductase (rnr) is an essential enzyme in all organisms. it provides precursors for dna synthesis by reducing all four ribonucleotides to deoxyribonucleotides. the overall activity and the substrate specificity of rnr are allosterically regulated by deoxyribonucleoside triphosphates and atp, thereby providing balanced dntp pools. we have characterized the allosteric regulation of the class iii rnr from bacteriophage t4. our results show that the t4 enzyme has a single type of allo ... | 2000 | 10748029 |
| determination of the free-energy change for repair of a dna phosphodiester bond. | the repair of phosphodiester bonds in nicked dna is catalyzed by dna ligases. ligation is coupled to cleavage of a phosphoanhydride bond in a nucleotide cofactor resulting in a thermodynamically favorable process. a free energy value for phosphodiester bond formation was calculated using the reversibility of the t4 dna ligase reaction. the relative number of dna nicks to phosphodiester bonds in a circular plasmid dna, formed during this reaction at fixed concentrations of atp to amp and pp(i), w ... | 2000 | 10748184 |
| results of surgical resection of oesophageal carcinoma in singapore. | the 5-year survival rate after resection of oesophageal cancer is still poor, reported to be between 5% to 34% in the literatures. we conducted this retrospective study to determine the prognostic factors and long-term survival rate for surgical resection of oesophageal carcinoma in singapore. | 2000 | 10748966 |
| radical radiotherapy for inoperable non-small cell lung cancer: what factors predict prognosis? | we set out to determine the factors that predict the outcome of conventional radical radiotherapy for inoperable non-small cell lung cancer. a retrospective casenote review was carried out of all 69 patients treated between 1986 and 1992 at the northern ireland centre for clinical oncology, belfast, with radical radiotherapy for inoperable non-small cell lung cancer. the tumour dose ranged from 45 gy to 67.5 gy, delivered in 15-30 fractions, 5 days per week over 3-6 weeks. all patients were foll ... | 2000 | 10749020 |
| [new possibilities in the diagnosis and documentation using 3d power doppler ultrasound with carcinoma of the floor of the mouth as illustration]. | to evaluate a novel 3d power doppler ultrasound-technique (3d pdus) in the diagnosis and documentation of tumours of the floor of the mouth. | 2000 | 10746281 |
| long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes. | we have developed a ruminant model to study long-term alterations in adiposity on the expression of appetite-regulating peptides in the hypothalamus. in this model endocrine and metabolic status are fully defined as well as body composition. the current study sought to define the effects of altered adiposity on the expression of genes for neuropeptide y (npy), pomc, enkephalin (enk), and melanin-concentrating hormone (mch). ovariectomized ewes with high (60 +/- 1 kg) (fat) or low (37 +/- 3 kg) b ... | 2000 | 10746657 |
| cutting edge: activation of hiv-1 transcription by the mhc class ii transactivator. | both macrophages and activated cd4+ t cells can be productively infected by hiv-1, and both cell types express mhc class ii molecules. expression of mhc class ii proteins in these cells is regulated by a specific transcriptional coactivator, the class ii transactivator (ciita). in this study, we report for the first time that ciita expression profoundly influences hiv-1 replication. stable expression of ciita in jurkat cells markedly increased 1) hiv-1 replication as assessed by the p24 ag produ ... | 2000 | 10754282 |
| quantitative eeg in schizophrenic patients before and during pharmacotherapy. | the aim of the study was to determine the possible differences in quantitative eeg parameters of schizophrenic patients before and during therapy with neuroleptics. first eeg recordings were obtained from schizophrenic patients (n = 50) who had not been taking any medicaments during the preceding 2 months. second eeg recordings were obtained during the administration of neuroleptic therapy. amplitude values of particular spectral segment, i.e. delta, theta, alpha 1, alpha 2, beta 1 and beta 2 (a ... | 2000 | 10754432 |
| loss of heterozygosity analysis on chromosome 5p defines 5p13-12 as the critical region involved in tumor progression of bladder carcinomas. | we have previously observed loss of heterozygosity (loh) at a single locus (del-27) on human chromosome 5p13-12 to correlate with bladder tumor progression. in this study, we examined 33 bladder tumors for their pattern of allelic loss on chromosome 5p using 7 microsatellite markers. in 14 of 15 bladder tumors with loh at locus del-27, allelic loss was confined to chromosomal region 5p13-12. this region included the microsatellite marker d5s2025 that showed loh in 5 of 11 (45%) informative cases ... | 2000 | 10754499 |
| recombination-dependent dna replication in phage t4. | studies in the 1960s implied that bacteriophage t4 tightly couples dna replication to genetic recombination. this contradicted the prevailing wisdom of the time, which staunchly supported recombination as a simple cut-and-paste process. more-recent investigations have shown how recombination triggers dna synthesis and why the coupling of these two processes is important. results from t4 were instrumental in our understanding of many important replication and recombination proteins, including the ... | 2000 | 10754548 |
| the incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium. | residual neuromuscular block caused by vecuronium alters pharyngeal function and impairs airway protection. the primary objectives of this investigation were to radiographically evaluate the swallowing act and to record the incidence of and the mechanism behind pharyngeal dysfunction during partial neuromuscular block. the secondary objective was to evaluate the effect of atracurium on pharyngeal function. | 2000 | 10754616 |
| effect of hypothyroidism on the testes in mature rats and treatment with levothyroxine and zinc. | this study was performed to investigate the effect of propylthiouracil (ptu) on rat testis, and to compare the results of the different treatment regimens of levothyroxine and zinc. twenty sexually mature wistar albino rats were subjected to ptu for 14 days intraperitoneally to make them hypothyroidic. the effect of ptu on testicular function was assessed histopathologically after unilateral orchiectomy on day 15, and treatment was evaluated by measuring serum thyroid-stimulating hormone (tsh), ... | 2000 | 10755190 |
| inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet. | propylthiouracil (ptu) or low-iodine diet (lid) treatment increases thyroid-follicular-cell proliferation, possibly by disrupting the movement of small molecules (< 1.2 kd) through membrane channels called gap junctions. numerous tumor promoters and proliferative disease states exhibit inhibited gap-junctional-intercellular communication (gjic) prior to the induction of cell proliferation, yet the association between gjic and apoptosis is unclear. in the present study, we used an ex vivo method ... | 2000 | 10755705 |
| spectroscopic studies on ethidium bromide binding to intramolecular parallel and antiparallel triple helices containing t*a:t and g*g:c triplets. | the interaction of ethidium bromide (eb), a dna intercalator, with two intramolecular triplexes 5'd(g4a4g4-[t4]-c4t4c4-[t4]-g4t4g4), 5'd(g4t4g4-[t4]-g4a4g4-[t4]-c4t4c4) ([t4] represents a stretch of 4 thymine residues) and their precursor duplexes has been investigated by circular dichroism, fluorescence and uv absorption spectroscopy. binding of eb induces a circular dichroism band in the region around 310 nm which is positive for the duplex forms but negative for the triplex forms. we observed ... | 2000 | 10798532 |
| haemodynamic changes during minimally invasive coronary artery bypass surgery using high-dose esmolol. | we aimed to investigate the effects of high-dose esmolol on haemodynamics and oxygen extraction in minimally invasive direct coronary artery bypass (midcab) surgery patients. | 2000 | 10799829 |
| high prevalence of thyroid abnormalities in a chilean psychiatric outpatient population. | the aim of the present study was to establish the prevalence of thyroid disturbances in patients consulting for panic and mood disorders. these data may be relevant because thyroid functional alterations affect the success of treatment in these pathologies. we studied prospectively 268 psychiatric outpatients (204 females and 64 males) diagnosed by dsm-iv criteria. we excluded patients with addictive disorders and major medical disease. we measured tsh, free t4 (ft4) and antimicrosomal antibodie ... | 2000 | 10800763 |
| identification of initiation sites for t4 lysozyme folding using cd and nmr spectroscopy of peptide fragments. | using cd and 2d (1)h nmr spectroscopy, we have identified potential initiation sites for the folding of t4 lysozyme by examining the conformational preferences of peptide fragments corresponding to regions of secondary structure. cd spectropolarimetry showed most peptides were unstructured in water, but adopted partial helical conformations in tfe and sds solution. this was also consistent with the (1)h nmr data which showed that the peptides were predominantly disordered in water, although in s ... | 2000 | 10801343 |
| the major head protein of bacteriophage t4 binds specifically to elongation factor tu. | the lit protease in escherichia coli k-12 strains induces cell death in response to bacteriophage t4 infection by cleaving translation elongation factor (ef) tu and shutting down translation. suicide of the cell is timed to the appearance late in the maturation of the phage of a short peptide sequence in the major head protein, the gol peptide, which activates proteolysis. in the present work we demonstrate that the gol peptide binds specifically to domains ii and iii of ef-tu, creating the uniq ... | 2000 | 10801848 |
| 3d conformal radiation therapy (3dcrt) for high grade prostate cancer: a multi-institutional review. | to evaluate the results of 3dcrt and the effect of higher than traditional doses in patients with high grade prostate cancer, we compiled data from three institutions and analyzed the outcome of this relatively uncommon subset of prostate cancer patients. | 2000 | 10802357 |
| chemoradiotherapy for muscle invading bladder carcinoma. final report of a single institutional organ-sparing program. | chemoradiotherapy is becoming an alternative to radical cystectomy among patients with muscle invading bladder cancer. we began a prospective study in 1988 to determine the possibilities of conservative treatment and aiming to improve the results obtained by cystectomy alone in invasive bladder cancer. a combination of methotrexate, vinblastine, adriamycin, and cisplatin (m-vac), followed by radiotherapy and concomitant cisplatin was used. | 2000 | 10802362 |
| skull-base invasion of nasopharyngeal carcinoma: magnetic resonance imaging findings and therapeutic implications. | to evaluate the value of skull-base abnormality on mri for predicting local recurrence in nasopharyngeal carcinoma. | 2000 | 10802365 |
| locally advanced nasopharyngeal carcinoma: computed tomography findings, clinical evaluation, and treatment outcome. | we present our experience with computed tomography (ct) for delineating the extent of bone erosion in nasopharyngeal carcinoma (npc) and propose that a new subdivision of stage t4 disease be added to the staging criteria for cases of minimal bone disease, defined as erosion of the base of the sphenoid or the pterygoid without cranial nerve (cn) involvement. | 2000 | 10802366 |
| local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma. | to evaluate the treatment outcome, patterns of failure, and prognostic factors for patients with unresectable hepatocellular carcinoma (hcc) treated with local radiotherapy alone or as an adjunct to transcatheter arterial chemoembolization (tace). | 2000 | 10802371 |
| seasonal variations of thyroid hormone levels in wild fish. | variations in plasma thyroxine (t4) and triiodothyronine (t3) contents of pike, pikeperch, perch, bream and chub from a large reservoir (pareloup, south of france) were investigated before and during the progressive emptying of the reservoir. fish were caught by gill nets, except at the last time of emptying when controls were collected with landing nets. both iodothyronine levels showed desynchronized seasonal cycles resulting in higher t3/t4 ratios in fish stressed by gill-netting in early sum ... | 2000 | 10803347 |
| monitoring iodine following consumption of iodized salt in tehrani inhabitants. | as the production, distribution and consumption of iodized salt has increased in recent years, this study was carried out to assess iodine status in tehran in 1996. 1146 families comprising 5140 subjects in the twenty districts of tehran city from all age groups were randomly selected. thyroid size was examined by palpation and graded according to the who classification. in 163 families selected randomly, thyroid size was determined by ultrasonography and urinary iodine was measured by digestion ... | 2000 | 10804458 |
| pre- and postresection thoracic washings in non-small cell carcinoma of the lung: a cytological study of 44 patients without pleural effusion. | the presence of malignant pleural effusion in patients with non-small cell bronchogenic cancer has a poor prognostic significance and is indicative of advanced disease (t4, iiib). the present study will investigate the role of cytology and identify the various cellular components seen in thoracic washings, in the absence of an effusion, and will identify the potential pitfalls in diagnosing these specimens. the sensitivity, specificity, and positive and negative predictive values will be determi ... | 2000 | 10787140 |
| treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. | differentiated thyroid cancer (dtc) patients, especially the 10% to 15% at high risk of cancer-related death, should have long-term monitoring for detection of recurrence or metastasis. conventional radiologic and ultrasonographic imaging is useful for localization of recurrent or persistent disease. for patients who have had ablation of residual thyroid tissue, measurement of serum thyroglobulin (tg) levels and radioactive iodine (rai) imaging provide highly sensitive tools for early detection. ... | 2000 | 10787191 |
| increased killing of bacillus subtilis on the hair roots of transgenic t4 lysozyme-producing potatoes. | transgenic potato plants expressing the phage t4 lysozyme gene which are resistant to the plant-pathogenic enterobacterium erwinia carotovora subsp. carotovora have been constructed. the agricultural growth of these potatoes might have harmful effects on soil microbiota as a result of t4 lysozyme release into the rhizosphere. to assess the bactericidal effect of roots, we have developed a novel method to associate the cells of bacillus subtilis with hair roots of plants and to quantify the survi ... | 2000 | 10788351 |
| identification and typing of human papillomavirus (hpv) in squamous cell carcinoma of the oral cavity and oropharynx. | recent epidemiological research has raised the possibility of a connection between viral infection by the human papilloma virus (hpv) and the existence of squamous cell carcinoma of the oral cavity and oroharynx (scca). some 60 subtypes have been identified to date, and specific subtypes are associated with lesions or infections at specific tissue sites. twenty-three patients with scca of the oral cavity were studied for the presence of hpv in their tumours. hpv dna (all type 16) was isolated fr ... | 2000 | 10789410 |
| pancreatic or duodenal resection or both for advanced carcinoma of the right colon: is it justified? | the role of extended resections for locally advanced carcinomas of the right colon infiltrating duodenum and pancreas remains unclear. this investigation was undertaken to review our experience with pancreatic head or duodenal resections for advanced right-sided colon cancer. | 2000 | 10789739 |
| evaluation of the liaison thyroid chemiluminescence immunoassays. | the liaison thyroid hormone assays tsh, ft4, ft3, t4 and t3 were evaluated by determining the imprecision, the reference ranges, the functional sensitivity (tsh), the dilution characteristics (accuracy) (ft4, ft3), and the recovery after spiking (tsh, t4, t3). furthermore, inter-method comparisons were performed with following methods: elecsys (roche diagnostics; tsh), axsym (abbott diagnostics; tsh, ft4, ft3, t4), acs:180 (bayer diagnostics; all analytes), amerlex-m (johnson & johnson; t4) and ... | 2000 | 10791127 |
| postoperative results of left upper abdominal evisceration for advanced gastric cancer. | in spite of the improvement of surgical techniques, the prognosis of patients with advanced gastric cancer still remains poor. with the aim of achieving en bloc resection of primary tumor, peritoneal dissemination on the greater omentum and lymph node metastasis, left upper abdominal evisceration (luae) was performed for 75 patients. in this report, we investigated the prognostic difference between the luae group and standard gastrectomy (total gastrectomy + pancreatosplenectomy). | 2000 | 10791241 |
| comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. dutch deep hyperthermia group. | local-control rates after radiotherapy for locally advanced tumours of the bladder, cervix, and rectum are disappointing. we investigated the effect of adding hyperthermia to standard radiotherapy. | 2000 | 10791373 |
| oligomerization, secretion, and biological function of an anchor-free parainfluenza virus type 2 (pi2) fusion protein. | a number of studies indicate that the transmembrane domain, the cytoplasmic domain, or both regions of viral surface glycoproteins are involved in quaternary structure formation. in this report, the transmembrane domain and cytoplasmic tail coding sequence of the fusion (f) glycoprotein gene from parainfluenza type 2 virus was truncated by pcr and the resulting gene (pi2f') was expressed in hela-t4 cells by using the vaccinia virus-t7 transient expression system. pulse-chase experiments indicate ... | 2000 | 10792996 |
| hormonal profiles and estrogen receptors in egyptian female breast cancer patients. | hormones are considered to be an important factor in the etiology of breast cancer. serum hormonal profiles of premenopausal and postmenopausal breast cancer patients as well as estrogen receptor (er) concentrations in breast cancer tissues were examined in an attempt to establish a possible association between hormones and breast cancer risk and to elucidate the biological features of the disease among egyptian female patients. | 2000 | 10778762 |
| the rat hepatic lectin-1 subunit of the asialoglycoprotein receptor is upregulated by thyrotropin and downregulated by neoplastic transformation of thyroid cells. | we have recently shown that the rat hepatic lectin (rhl)-1 subunit of the asialoglycoprotein receptor (asgpr) is expressed in the pc c13 differentiated thyroid cell line. to investigate in vivo the expression of rhl-1 and the ability of thyrotropin (tsh) to modulate its expression, reverse-transcriptase polymerase chain reaction (rt-pcr) and western blot assays have been performed on thyroid extracts from rats treated with thyroxine (t4) or propylthiouracil (ptu), each of which modulates tsh lev ... | 2000 | 10779134 |
| maturation of human hypothalamic-pituitary-thyroid function and control. | measurements of serum thyrotropin (tsh) and free thyroxine (t4) concentrations were conducted in infants, children, and adults to assess maturation of the hypothalamic-pituitary-thyroid (hpt) feedback control axis. serum free t4 and tsh concentration data were collated for cord blood of the midgestation fetus, for premature and term infants, and for peripheral blood from newborn infants, children, and adults. mean values were plotted on a nomogram developed to characterize the reference ranges o ... | 2000 | 10779137 |
| neuropsychological follow-up in early-treated congenital hypothyroidism: a problem-oriented approach. | screening programs for congenital hypothyroidism (ch) dramatically improved the neuropsychological prognosis in affected children. however, mild impairments in cognitive performances, poorer motor skills, defective language abilities, and learning problems have been reported in some studies of early-treated ch children. the occurrence of these defects makes neuropsychological follow-up mandatory. the aim of the present study was to identify those neuropsychological functions that are more freque ... | 2000 | 10779139 |
| a case of sarcoidosis and sarcoid granuloma, papillary carcinoma, and graves' disease in the thyroid gland. | sarcoidosis is a systemic chronic granulomatous disease of unknown etiology most commonly affecting young females. the disease was first described in the thyroid gland in 1938. our patient, a 27-year-old male with known sarcoidosis, was referred to the national university hospital for acute symptoms of thyrotoxicosis (weight loss of 6 kg, tremor, thyroid enlargement, and tachycardia). laboratory findings showed suppressed serum thyrotropin (tsh, <0.03 mu/l [0.5-4.20]), increased total thyroxine ... | 2000 | 10779143 |
| [quality of life after treatment of laryngeal carcinoma: surgery versus radiotherapy]. | radiotherapy and surgery for laryngeal cancer achieve comparable results in patient survival. therefore, the expected quality of life is increasingly influencing the choice of treatment. the aim of this study was to compare the quality of life of patients after surgery or radiotherapy for laryngeal carcinoma. to evaluate quality of life, we used the validated european organization for research and treatment of cancer quality of life questionnaire core 30 (eortc qlq-c30) and the eortc head and ne ... | 2000 | 10780067 |
| [hypothyroidism after combined surgical and radiotherapy treatment of cancer of the orl area]. | hypothyroidism is a well described complication of head and neck cancer treatment, but routine testing of thyroid function is generally not done. the combination of surgery and radiotherapy seems to increase the risk of thyroid hypofunction. | 2000 | 10780072 |
| the effects of long-term caging and molt of single comb white leghorn hens on heterophil to lymphocyte ratios, corticosterone and thyroid hormones. | two commercial strains of 18-wk-old single comb white leghorn (scwl) hens, hyline w-36 and dekalb xl, were housed six hens per cage in layer cages at two densities (361 and 482 cm2 per bird) with two replications each per strain and density combination. the high density treatment contained 24 hens per replication, and the low density treatment contained 18 hens per replication. egg production was measured during the first egg production cycle, a molt (fast) period, and the first 4 wk of the seco ... | 2000 | 10780646 |
| quantitative eeg in 'positive' and 'negative' schizophrenia. | quantitative eeg has yielded different results in schizophrenia. the method of quantitative eeg has been relatively poorly used in the studies of the dichotomy into positive and negative schizophrenia. | 2000 | 10782551 |
| stability of bacteriophage t4 short tail fiber. | adsorption of t-even bacteriophages to the e. coli host cell is mediated by long and short tail fibers. bacteriophage t4 short tail fiber protein p12 was used to investigate the stability against thermal and chemical denaturation. purified p12 is thermostable with a melting point of 78 degrees c. guanidinium chloride-induced denaturation displayed strong hysteresis and an intermediate between 2 and 3 m denaturant. the transitions occur at 1.5 and 3.2 m denaturant as revealed by fluorescence spec ... | 2000 | 10782996 |
| aorto-coronary dissection during angioplasty in a patient with myxedema. | a 67-year-old man with overt hypothyroidism and medically controlled hypertension was admitted for coronary angiography because of exertional angina. his triiodothyronine (t3) and thyroxine (t4) levels had been low for 4 years. although signs and symptoms of hypothyroidism were apparent, his hypercholesterolemia was mild. coronary angiography revealed an eccentric stenosis in the distal portion of the right coronary artery and it was decided to perform angioplasty because his angina had continue ... | 2000 | 10783057 |
| evaluation of a tier i screening battery for detecting endocrine-active compounds (eacs) using the positive controls testosterone, coumestrol, progesterone, and ru486. | after previously examining 12 compounds with known endocrine activities, we have now evaluated 4 additional compounds in a tier i screening battery for detecting endocrine-active compounds (eacs): a weak estrogen receptor (er) agonist (coumestrol; coum), an androgen receptor (ar) agonist (testosterone; test), a progesterone receptor (pr) agonist (progesterone; prog), and a pr antagonist (mifepristone; ru486). the tier i battery incorporates 2 short-term in vivo tests (5-day ovariectomized female ... | 2000 | 10774816 |
| [coliphages inactivation using chitosan derivatives]. | the effect of chitosan fragments with different degrees of polymerization and the chemical derivatives of chitosan differing in the number of amino groups and total molecule charge on phages t2, t4, and t7 was studied. the interaction of chitosan with bacteriophage particles inactivated them to the extent dependent on the chemical properties of chitosan and its concentration. phage t2 was found to be most susceptible to inactivation by chitosan. the polycationic nature of chitosan plays an impor ... | 2000 | 10776628 |
| [circadian rhythms of hypophysis-thyroid hormones secretion in patients with bronchial asthma]. | to examine circadian rhythms of hypophysiothyroid system in patients with bronchial asthma and effects of exogenic glucocorticoids on thyroid function. | 2000 | 10776645 |
| accelerated hyperfractionation for bronchogenic cancer: radiation therapy oncology group 9205. | rtog 92-05 was a phase ii trial developed to evaluate the feasibility, toxicity, and acceptance of a three times daily accelerated hyperfractionation radiation therapy schedule delivering 110 cgy, three times daily, to 79.2 gy uncorrected tumor dose in 72 fractions, in 24 treatment days, in patients with bronchogenic cancer. the radiographically visible tumor received accelerated hyperfractionation and the other radiation volume received standard hyperfractionation. three times a day, a dose of ... | 2000 | 10776986 |
| a t4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5'-triphosphate for activation. | a deoxycytidylate (dcmp) deaminase encoded in t4-bacteriophage dna that is induced on phage infection of escherichia coli was shown earlier (maley, g. f., duceman, b. w., wang, a. m., martinez, j. m., and maley, f. (1990) j. biol. chem. 265, 47-51) to be similar in size, properties, and amino acid composition to the t2-phage-induced deaminase. neither enzyme is active in the absence of dctp or its natural activator, 5-hydroxymethyl-dctp. however, on changing the arginine (arg) at residue 115 of ... | 2000 | 10777550 |
| effect of biocontrol strains of trichoderma on plant growth, pythium ultimum polulations, soil microbial communities and soil enzyme activities. | five strains of trichoderma with known biocontrol activities were assessed for their effect upon pea growth and their antagonistic activity against large pythium ultimum inocula. the effect of trichoderma inocula upon the indigenous soil microflora and soil enzyme activities in the presence and absence of pythium is assessed. in the absence of pythium, trichoderma strain n47 significantly increased the wet shoot weight by 15% but did not significantly affect the dry weight, whilst strains t4 and ... | 2000 | 10735255 |
| aggressive multimodality therapy for stage iii esophageal cancer: a phase i/ii study. | stage iii advanced locoregional esophageal carcinoma is frequently unresectable and inconsistently represented in therapeutic trials of esophageal cancer. | 2000 | 10735664 |
| dopaminergic and cholinergic involvement in the inhibitory effect of dexamethasone on the tsh response to trh. | glucocorticoid administration is associated with reduced basal thyroid-stimulating hormone (tsh) levels and a blunted tsh response to thyrotropin-releasing hormone (trh), despite thyroid hormone levels within the normal range. in light of the inhibitory effect of somatostatin and dopamine on tsh secretion, we examined whether this condition is caused by glucocorticoids through an increased hypothalamic somatostatinergic and/or dopaminergic inhibitory control of tsh. we measured the tsh response ... | 2000 | 10736973 |
| prognostic indicators for renal cell carcinoma: a multivariate analysis of 643 patients using the revised 1997 tnm staging criteria. | we determine independent prognostic indicators for renal cell carcinoma using the revised 1997 tnm staging criteria. | 2000 | 10737472 |
| potent and selective tools to investigate neuropeptide y receptors in the central and peripheral nervous systems: bib03304 (y1) and cgp71683a (y5). | we have evaluated 3 newly developed neuropeptide y receptor antagonists in various in vitro binding and bioassays: bibo3304 (y1), t4[npy33-36]4 (y2), and cgp71683a (y5). in rat brain homogenates, bibo3304 competes for the same population of [125i][leu31,pro34] peptide yy (pyy) binding sites (75%) as bibp3226, but with a 10 fold greater affinity (ic50 of 0.2 +/- 0.04 nm for bibo3304 vs. 2.4 +/- 0.07 nm for bibp3226),while cgp71683a has high affinity for 25% of specific [125i][leu31,pro34]pyy bind ... | 2000 | 10737674 |
| [prognostic influence of cutaneous involvement in malignant tumors of the oral cavity]. | the aim of this study was to assess the prognostic influence of cutaneous involvement in t4 squamous cell carcinoma of the oral cavity. the population was a homogeneous group of 137 patients. cutaneous tumor localizations were observed in 20 of them. surgery and radiotherapy were given in 103 cases and salvage surgery was performed in 34. local control at 5 years was achieved in 68.5 % of the patients. carcinologic failure rate was 55 % and 27.3 % in patients with and without cutaneous involveme ... | 2000 | 10739997 |
| hyperbaric bupivacaine for spinal anaesthesia in 7-18 yr old children: comparison of bupivacaine 5 mg ml-1 in 0.9% and 8% glucose solutions. | we have compared two hyperbaric bupivacaine solutions for spinal anaesthesia in 7-18-yr-old school-aged children in a double-blind, randomized, parallel group, prospective study. children were premedicated with diazepam orally. half of the patients were sedated with either midazolam or thiopental. after lumbar puncture with a 27-gauge spinal needle, bupivacaine 5 mg ml-1 in either 0.9% or 8% glucose was injected in a dose of 0.3 mg kg-1. maximum cephalad spread and regression of block were teste ... | 2000 | 10740548 |
| theoretical studies of the response of a protein structure to cavity-creating mutations. | we have investigated the response of a protein structure to cavity-creating mutations by molecular dynamics (md) simulations for the wild-type and the five mutants of phage t4 lysozyme. essential dynamics (ed) analysis and the methods for calculating different components of local interaction energies are used to examine the structural and energetic characteristics associated with the mutations. in agreement with the x-ray results, it is found that the structural changes due to the replacements o ... | 2000 | 10733949 |
| one tube mutation detection using sensitive fluorescent dyeing of muts protected dna. | a novel, universal method for mutation detection utilising the ability of muts protein to recognise dna incomplementarities is proposed. the examined and reference dna fragments are pcr amplified. the pcr products are purified, mixed, heated and cooled to form heteroduplexes. in the case of mutation the heteroduplex dna containing mismatch is protected against exonuclease digestion by muts, while the dna without mismatches is degraded. the protection effect is visualised by the direct addition o ... | 2000 | 10734213 |
| [chronobiological characteristics of renal function under conditions of t4- and t3-hyperthyreosis]. | hyperthyreosis in rats after 10 days of injecting t4 at the dose of 100 mg/kg of the body mass modified the chronostructure of renal functions by decreasing rhythms of the urinal ph mesor, and elevating rhythms of creatinine and protein excretion mesors, and the mesor and the amplitude of sodiuresis rhythms. temporal readjustment of renal functions reflects peculiarities of the body adaptation to t4-induced hyperthyreosis. injections of t3 (20 mg/kg of the body mass) during 10 days do not lead t ... | 2000 | 10732198 |
| quality of life in patients with early and advanced carcinoma of the breast. | emotional disturbances are known to occur in patients suffering from malignant diseases even after treatment. this is mainly because of a fear of death which modifies quality of life (qol). qol has gained an important place in the management of cancer in industrialized nations, with the increase in survival. however, in developing countries like india, very little attention has been paid to this issue. developing countries have poor infrastructure and lack proper treatment facilities at most cen ... | 2000 | 10718174 |
| conservative surgery in t3-t4 pharyngolaryngeal squamous cell carcinoma: an alternative to radiation therapy and to total laryngectomy for good responders to induction chemotherapy. | to evaluate the possibility of preservation of the larynx after neoadjuvant chemotherapy by performing a conservative surgery instead of total laryngectomy initially planned, in patients with previously untreated laryngeal and piriform sinus squamous cell carcinoma (scc). | 2000 | 10718429 |
| the thyroxine-binding proteins. | the slow clearance, prolonged half-life, and high serum concentration of thyroxine (t4) are largely due to strong binding by the principal plasma thyroid hormone-binding proteins, thyroxine-binding globulin (tbg), transthyretin (ttr), and albumin. these proteins, which shield the hydrophobic thyroid hormones from their aqueous environment, buffer a stable free t4 concentration for cell uptake. free rather than bound t4 is subject to homeostatic control by the hypothalamic-pituitary thyroid axis. ... | 2000 | 10718550 |
| determinants of thyroid volume in healthy french adults participating in the su.vi.max cohort. | to study the relative importance of determinants of thyroid volume. | 2000 | 10718824 |
| radiotherapy of advanced mycosis fungoides: indications and results of total skin electron beam and photon beam irradiation. | the goals of this retrospective study of advanced mycosis fungoides are (1) to describe the indications of a combination of total skin electron beam and photon beam irradiation and (2) to analyze the results of total body or segmental photon irradiation for patients with extension beyond the skin. | 2000 | 10719702 |
| congenital hypothyroidism with impaired thyroid response to thyrotropin (tsh) and absent circulating thyroglobulin: evidence for a new inactivating mutation of the tsh receptor gene. | congenital hypothyroidism due to impaired thyroid response to tsh was originally described by stanbury. a diagnosis of congenital hypothyroidism with thyroid unresponsiveness to tsh is accepted if the patient has congenital hypothyroidism, the thyroid gland is in the normal position in the neck, the size of the thyroid is either normal or atrophic, the serum tsh level is increased, the bioactivity of tsh is intact, and the response of the thyroid gland to tsh stimulation is decreased. in all ori ... | 2000 | 10720030 |
| age and gender predict the outcome of treatment for graves' hyperthyroidism. | the response to treatment in graves' hyperthyroidism is unpredictable, and factors postulated to predict outcome have not generally proved clinically useful or been widely adopted in clinical practice. we audited outcome in 536 patients with graves' hyperthyroidism presenting consecutively to determine whether simple clinical features predict disease presentation and response to treatment. at presentation males had slightly more severe biochemical hyperthyroidism [free t4: males, 64.3 +/- 3.0 pm ... | 2000 | 10720036 |
| plasma total homocysteine levels during short-term iatrogenic hypothyroidism. | hypothyroidism is associated with increased cardiovascular morbidity, which cannot be fully explained by the atherogenic lipid profile observed in these patients. we have previously found elevated levels of the cardiovascular risk factor, plasma total homocysteine (thcy), in hypothyroidism. we conducted a longitudinal study on 17 patients who had undergone total thyroidectomy for thyroid cancer. during 6 weeks of discontinued t4 substitution before radioscintigraphy (phase i), they attained a hy ... | 2000 | 10720038 |
| long-term follow-up of clinical symptoms in tmd patients who underwent occlusal reconstruction by orthodontic treatment. | fifty-eight patients (mean age 18.4 years) who had received splint therapy for internal derangement of the temporomandibular joint (tmj) were examined retrospectively to investigate the efficacy of occlusal reconstruction by orthodontic treatment. the subjects were divided into three groups: 18 patients (mean age 18.6 years) who underwent orthodontic treatment combined with the use of splints (st group); 27 patients (mean age 18.2 years) who underwent orthodontic treatment without the use of spl ... | 2000 | 10721246 |
| the use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx. | management of the clinically negative neck among patients with oral and oropharyngeal squamous cell carcinoma at the royal prince alfred hospital, sydney, australia has been based on the site and stage of the primary cancer, the likely incidence of microscopic nodal involvement, the treatment modality used for the primary cancer, and whether the neck will be entered during resection or reconstruction. this report analyzes the results of treatment when patients are allocated to either treatment o ... | 2000 | 10722009 |
| ipsilateral neck cancer recurrences after elective supraomohyoid neck dissection. | retrospective analysis of a case series. | 2000 | 10722018 |
| management of malignant melanoma of the head and neck using dynamic lymphoscintigraphy and gamma probe-guided sentinel lymph node biopsy. | the sentinel lymph node (sln) biopsy is revolutionizing the surgical management of primary malignant melanoma. it allows accurate nodal staging, and targets patients who may benefit from regional lymphadenectomy and systemic therapy; however, its use in the management of head and neck melanoma has not been widely accepted. | 2000 | 10722024 |