Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| thyroxine enhancement and the role of reactive oxygen species in tadpole tail apoptosis. | our objective is to clarify the role of reactive oxygen species (ros) in the atrophying tail of anuran tadpoles (tail apoptosis). changes in catalase, superoxide dismutase (sod) and caspase activity, genomic dna, and nitric oxide (no) generation were investigated biochemically using rana japonica tadpole tails undergoing regression during thyroid hormone enhancement. dna fragmentation and ladder formation with concomitant shortening of tadpole tail were induced by dl-thyroxine (t4) in culture me ... | 1999 | 10232845 |
| contemporary results of radical radiotherapy for bladder transitional cell carcinoma in a district general hospital with cancer-centre status. | to assess the current efficacy and safety of definitive external beam radiotherapy (ebrt) in the treatment of invasive bladder transitional cell carcinoma (tcc) in a district general hospital with cancer-centre status. | 1999 | 10233566 |
| extraction and quantification of thyroid hormones in selected regions and subcellular fractions of the rat brain. | there is increasing evidence of an involvement of thyroid hormones in numerous physiological processes of the adult vertebrate brain. however, the only valid method available for measuring triiodothyronine (t3) in brain tissue is time-consuming and not sufficiently sensitive to determine hormone concentrations in small, but physiologically important areas such as the amygdala and septum. we therefore developed a protocol for reliable measurement of the concentrations of thyroxine (t4) and t3 in ... | 1999 | 10234449 |
| rna switches the higher-order structure of dna. | by the direct observation of single duplex dna molecules by fluorescence microscopy, we found that rna molecules have the potential to change discretely the higher-order structure of individual dna molecules between the compact and elongated states. we performed an experiment with a linear giant dna (t4 dna, 166 kbp) and a circular dna (cosmid vector, 42 kbp), and examined the effect of single-strand rna on their conformations under a physiological concentration of spermidine. individual dna cha ... | 1999 | 17030336 |
| immunohistochemical study of t lymphocyte subsets on frozen substituted plastic embedding section of the bone marrow from patients with myelodysplastic syndrome and its clinical implication. | an immunohistochemical study of t lymphocyte subsets on frozen substituted plastic embedding bone marrow sections obtained from 10 patients with myelodysplastic syndrome (mds) was presented. the results of qualitative and quantitative immunohistochemical analysis are as follows: (1) labile antigens of t lymphocytes were well preserved, thus allowing analysis of distribution of t lymphocyte subsets in situ: (2) the average number of t3, t4 and t8 lymphocyte of the diffuse infiltrate was about 2%, ... | 1999 | 12840893 |
| [surgical management of subglottic carcinoma]. | to explore the clinical features and the methods of surgery and functional restoration of subglottic carcinoma. | 1999 | 12764836 |
| [supracricoid partial laryngectomy for laryngeal cancer]. | to analyze the key points, especially the indications and contraindications of supracricoid partial laryngectomy (scpl). | 1999 | 12764838 |
| [cervical lymph node metastasis and recurrence in supraglottic carcinoma after operation]. | to evaluate the regional control efficacy of elective neck dissection (end) in patients with supraglottic carcinoma. | 1999 | 12764862 |
| purification of the bacteriophage t4 type ii dna topoisomerase. | 1999 | 12844873 | |
| [influence of pavulon on facial nerve monitoring during middle ear-mastoid operation]. | to evaluate the influence of pavulon (muscle relaxant) on facial nerve monitoring for patient with middle ear-mastoid operation during general anesthesia. | 1999 | 12541369 |
| [construction of streptococcus mutans surface protein antigen eukaryotic expression vector pcdna3-pac. ii. testified efficiency of repeated using glass fiber chromatographic column]. | to explore one method getting highly purified plasmid dna and costing low. | 1999 | 12539389 |
| [clinical observation of curative effect of neartotal larynegectomy for advance laryngeal cancer]. | to explore a method how to preserve the speech function affer larynegectomy for advance laryngeal cancer and to improve the patients' life quality. | 1999 | 12563969 |
| [effects of cyclosporin a combined with t4 on collagen iv production, coll alpha 1 (iv) mrna and tgf beta 1 mrna expression in cultured human mesangial cells]. | to investigate the effects of single cyclosporin a (csa), tripcholorlide (t4) or both on renal fibrosis. | 1999 | 12567430 |
| [experimental study on the effect of nourishing yin and tranquilizing of yangyin anshen koufuye]. | yangyin anshen koufuye could obviously decrease the spontaneous activity of rats, effectively shorten the process of falling into sleep of normal rats which were injected pentobarbital sodium and prolong the sleeping time. the effect of sedation and hypnotism were the same as zhaoren anshen koufuye. yangyin anshen koufuye also could markedly reduce the serum tensity of t3, t4 of hyperthyroid rats, which equaled to tcm's deficiency of yin. it also could prevent the glycogen content of liver from ... | 1999 | 12571916 |
| thermal transition profiles of bacteriophage t4 and its dna. | 1999 | 12501385 | |
| evaluation of an automated, homogeneous enzyme immunoassay for serum thyroxine measurement in dog and cat serum. | a homogenous enzyme immunoassay (eia) for measurement of serum thyroxine (t4) concentration was evaluated for use with canine and feline serum. the eia method was linear from 0 to 150 nmol t4/l for human serum, 0 to 94 nmol t4/l for feline serum and 10 to 60 nmol t4/l for canine serum. intra- and interassay precision studies yielded coefficients of variation </= 8% using single point measurements. method comparison studies gave close agreement between radioimmunoassay (ria) and eia results. corr ... | 1999 | 12075533 |
| oxford positioning technique improves haemodynamic stability and predictability of block height of spinal anaesthesia for elective caesarean section. | a novel positioning technique was tested to see whether the unpredictability of block height and haemodynamic instability during spinal anaesthesia for caesarean section could be reduced. in this 'oxford' position, the woman is placed left lateral with an inflated bag under the shoulder and pillows supporting the head. following spinal injection the woman is turned to an identical right lateral position. this is maintained until just before incision to minimise aorto-caval compression, when she ... | 1999 | 15321118 |
| value of routine 99mtc-mdp bone scintigraphy in the detection of occult skeletal metastases in women with primary breast cancer. | baseline staging bone scans in 208 women with primary breast cancer in university hospital kuala lumpur from january 1993 to december 1995 were reviewed. a positive bone scan was found in 14.7% of women aged below 50 years, and 9.1% of women aged 50 years and above. no patient with t0/t1, 4.7% with t2, 6.6% with t3 and 35.8% with t4 tumours had a positive scan caused by bone metastases. no patient with clinical stage 0/1, 4% with stage 2, 9.5% with stage 3 and 63% with stage 4 disease had a posi ... | 1999 | 14965742 |
| quantification of breast cancer blood flow in absolute units using gjedde-rutland-patlak analysis of 99mtc-mibi uptake. | scintimammography with 99mtc-mibi has been proven as efficient technique of diagnosis of breast cancer. nevertheless, quantification of breast carcinoma blood flow (bcbf) in absolute units is not yet developed. to compensate this, we analysed kinetics of 99mtc-mibi uptake in breast cancer using gjedde-rutland-patlak (grp) approach. | 1999 | 14600993 |
| differential induction of grapevine defenses by two strains of botrytis cinerea. | abstract even though botrytis cinerea, the causal agent of gray mold, is a highly variable fungus with strains displaying very different degrees of virulence toward one given host plant species, no study has yet shown any correlation between the lack of aggressiveness of one given strain and its ability to stimulate a defense response from its host. strains of b. cinerea collected from different host plant species were screened for their pathogenicity on grapevine to select two strains with simi ... | 1999 | 18944759 |
| the impact of primary tumor volume on local control for oropharyngeal squamous cell carcinoma treated with radiotherapy. | a study was needed to determine the effect of primary tumor volume on local control of oropharyngeal carcinoma treated with radiation therapy, with or without induction chemotherapy. | 2000 | 10585598 |
| survival and functional results of pearson's near-total laryngectomy for larynx and pyriform sinus carcinoma. | current treatment for most t3 and t4 transglottic and pyriform sinus carcinomas is total laryngectomy or total laryngectomy with partial pharyngectomy. voice rehabilitation usually requires the use of a tracheoesophageal puncture (tep). pearson's near-total laryngectomy (ntl) is an option for voice preservation in selected cases with no invasion of the interarythenoid space and limited invasion of the subglottis. the purpose of this study is to report the functional and survival results of 42 co ... | 2000 | 10585600 |
| selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. | we investigated the mechanism by which t4 regulates its activation to t3 by the type 2 iodothyronine deiodinase (d2). d2 is a short- lived (t1/2 50 min), 31-kda endoplasmic reticulum (er) integral membrane selenoenzyme that generates intracellular t3. inhibition of the ubiquitin (ub) activating enzyme, e1, or mg132, a proteasome blocker, inhibits both the basal and substrate-induced acceleration of d2 degradation. using a catalytically active transiently expressed flag-tagged-nh2-d2, we found ra ... | 2000 | 11075806 |
| postnatal thyroxine supplementation in infants less than 32 weeks' gestation: effects on pulmonary morbidity. | transient hypothyroxinemia in premature newborns has been linked with poor neonatal outcomes. we designed this study to evaluate the effects of early thyroxine (t4) administration in the premature infant. | 2000 | 11076326 |
| induction chemotherapy followed by alternating chemo-radiotherapy in stage iv undifferentiated nasopharyngeal carcinoma. | in locally advanced undifferentiated nasopharyngeal carcinoma (unpc), concomitant chemo-radiotherapy is the only strategy that gave better results over radiation alone in a phase iii trial. adding effective chemotherapy to a concomitant chemo-radiotherapy programme may be a way to improve the results further. 30 patients with previously untreated t4 and/or n2-3 undifferentiated nasopharyngeal carcinoma were consecutively enrolled and initially treated with 3 courses of epidoxorubicin, 90 mg/m2, ... | 2000 | 11076650 |
| changes in cardiac function at rest before and after treatment in primary hypothyroidism. | the aim of the present study was to investigate in hypothyroid patients the reversibility of the prolongation of electromechanical delay and of the impairment of early diastolic relaxation as measured by radionuclide ventriculography after restoration of euthyroidism. we also evaluated doppler echocardiography in relation to scintigraphic findings. twenty-six consecutive hypothyroid patients were studied at diagnosis and after treatment. the time to peak ejection decreased (161 +/- 6 vs 145 +/- ... | 2000 | 11078310 |
| association of hyperthyroidism with serum leptin levels. | the present study was undertaken to determine whether thyroid hormones affect serum leptin levels in patients with hyperthyroidism. in 32 female patients with hyperthyroidism and 30 body mass index (bmi)-matched control subjects, there was no difference in serum leptin concentrations (9.0+/-1.0 v 8.2+/-0.9 microg/l). the serum leptin levels were compared with the expected values for serum leptin derived from the corresponding bmi with the formula for the control subjects (serum leptin [microgram ... | 2000 | 11079817 |
| endoscopic ultrasonography in the preoperative staging of gastric cancer: accuracy and impact on surgical therapy. | endoscopic ultrasonography (eus) is a standard procedure in the preoperative staging of patients with gastric carcinomas. herein we present our experience with eus and discuss the results and their implications for surgical therapy. | 2000 | 11080410 |
| simultaneous determination of plasma ovarian and thyroid hormones during sexual maturation of the hen (gallus domesticus). | the concentrations of ovarian steroids (estradiol--e2, progesterone--p4 and testosterone--t) and thyroid hormones (thyroxine--t4 and triiodothyronine--t3) were determined in blood plasma of the domestic hen during sexual maturation and the initial period of egg lay. blood samples were collected from hy-line pullets at 3 day intervals from days 87 to 144 day of life, i.e. 42 days before and 14 days after the onset of egg lay (oel). ovarian and thyroid hormones were measured by ria methods. during ... | 2000 | 11080911 |
| efficacy of concomitant chemoradiation and surgical salvage for n3 nodal disease associated with upper aerodigestive tract carcinoma. | to determine whether an aggressive approach using trimodality therapy would improve the outcome in head and neck cancer patients with advanced (n3) nodal disease. | 2000 | 11081585 |
| resection of cancer of the tongue base and tonsil via the transhyoid approach. | to assess whether transhyoid resection of the tongue base and tonsil lesions is an effective approach to tumors involving this region compared with more traditional anterior surgical approaches that arbitrarily involve either segmental resection or division of the mandible. | 2000 | 11081588 |
| [amiodarone-induced hyperthyroidism]. | amiodarone is extensively used in cardiology practice because of its excellent antiarrhythmic properties. it produces alterations in thyroid functional because it contains 37% iodine and it is structurally similar to the thyroid hormones. amiodarone inhibits 5'-deiodinase in the liver. the incidence of amiodarone-induced hyperthyroidism is between 6% and 12% of treated patients. the figures for pediatric patients are similar. determination of tri-iodothyronine (t3), thyroxine (t4) and thyroid-st ... | 2000 | 11083993 |
| [positive antithyroglobulin antibodies in patients with differentiated thyroid carcinoma. what significance?]. | the aim of this retrospective study was to determine the predictive value of antithyroglobulin antibodies (tgab) in 238 patients with undetectable thyroglobulin after whole thyroidectomy for differentiated cancer and ablative dose of radioiodine. tgab titers were elevated in 30 patients with undetectable tg level after withdrawal of t4 treatment. in 21 patients, initially positive tgab titers became undetectable without clinical event within 3-84 months after therapy (median 12 months). in 2 cas ... | 2000 | 11084393 |
| effect of hyperthyroidism on insulin-like growth factor-i (igf-i) and igf-binding proteins in adolescent children. | a study was performed on adolescent hyperthyroid patients to determine the effects of hyperthyroidism on insulin-like growth factor (igf)-i and its binding proteins. serum concentrations of immunoreactive total and free igf-i, and igf binding protein (igfbp)-2 and igfbp-3 were determined before and after correction of hyperthyroidism in eight patients with grave's disease and compared to control patients matched for age, sex and pubertal stage. the concentration of serum total igf-i was not sign ... | 2000 | 11085184 |
| subtype specific downregulation of thyroid hormone receptor mrna by beta-adrenoreceptor blockade in the myocardium. | the beta-adrenergic system is very important in cardiovascular medicine. thyroid hormone (t3) affects beta-adrenergic receptors. in cell culture, isoproterenol, a beta-adrenergic agonist, has been shown to upregulate thyroid hormone receptor (tr) mrna, thus indicating a bi-directional regulation. the aim of this study was to evaluate if beta-adrenoreceptor blockade may affect subtype tr mrna expression in vivo. propranolol or vehicle was delivered by implanting an alzet osmotic pump subcutaneous ... | 2000 | 11085356 |
| [an effective case of intraperitoneal and intra-arterial combined chemotherapy for unresectably advanced borrmann type iv gastric carcinoma]. | we report an effective case of intraperitoneal and intra-arterial combined chemotherapy for unresectably advanced borrmann type iv gastric carcinoma. a 59-year-old man was admitted with advanced borrmann type iv gastric carcinoma in june 1999. with informed consent, the patient underwent laparotomy, which revealed far advanced stage iv gastric carcinoma of t4, n3, p1, h0, m1, cy1 for resection. three ports to both subphrenic pouches and douglas' pouch were placed for intraperitoneal infusion che ... | 2000 | 11086465 |
| effects of anesthesia, surgery, and intravenous administration of fluids on plasma antidiuretic hormone concentrations in healthy dogs. | to evaluate effects of anesthesia, surgery, and intravenous administration of fluids on plasma concentrations of antidiuretic hormone (adh), concentration of total solids (ts), pcv, arterial blood pressure (bp), plasma osmolality, and urine output in healthy dogs. | 2000 | 11039560 |
| hypopharyngeal squamous cell carcinoma--treatment results in 138 consecutively admitted patients. | the aim of this study was to evaluate the results of the initial and salvage treatment for hypopharyngeal carcinoma. the study was conducted in 1963 to 1991 and included 138 patients (38 females (28%) and 100 males (73%)). most of the tumours originated in the piriform sinus (86%). tumour stage distribution was t1: 20%, t2: 27%, t3: 37% and t4: 17% and nodal stage distribution was n0: 45%, n1: 25%, n2: 10%, and n3: 20%. primary treatment was delivered with curative intent in 124 out of 138 cases ... | 2000 | 11041117 |
| thyroid hormone stimulates na, k-atpase gene expression in the hemodynamically unloaded heterotopically transplanted rat heart. | regulation of myocardial na, k-atpase gene expression by thyroid hormone was investigated in the heterotopically transplanted rat heart to distinguish the direct effects of the hormone on the heart from effects secondary to increased hemodynamic workload. in this model, the transplanted heart is histologically normal and spontaneously beating, but hemodynamically unloaded. three days after transplantation, relative contents of ventricular na, k-atpase alpha2- and beta1-mrnas and alpha1- and alph ... | 2000 | 11041452 |
| changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment. | the aim of this prospective, follow-up study was to examine the influence of overt hypothyroidism (ohp) and subclinical (shp), before and during thyroxine (t4) treatment, on lipoprotein(a) [lp(a)], other lipoproteins, and apolipoproteins. twenty-four patients (17 females, 7 males) with ohp, aged 54 +/- 11.1 years (group a) and 23 patients (females) with shp aged 50.1 +/- 13.2 years (group b) were evaluated and compared to 34 and 38 controls, respectively. all patients received t4 therapy in a st ... | 2000 | 11041458 |
| dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. | biological effects of genistein are currently under investigation by the national toxicology program because of widespread and increasing soy consumption by humans and evidence for modulation of endocrine function. rats were exposed to genistein aglycone in soy-free feed fortified at 0, 5, 100, and 500 ppm starting in utero through 20 weeks. thyroid glands and serum were analyzed for total genistein (aglycone + conjugates) using hplc with electrospray mass spectrometric detection. microsomal thy ... | 2000 | 11042097 |
| carcinoma of the maxillary antrum: a retrospective analysis of 110 cases. | cancer of the maxillary antrum is a rare disease with a variety of treatment options. the present study was undertaken to review the outcome of patients with carcinoma of the maxillary antrum managed at a single institution. | 2000 | 11054520 |
| hypothyroidism and depression: a therapeutic challenge. | to describe a patient with longstanding depression and hypothyroidism who had marked mood improvement only after triiodothyronine (t3) was added to her thyroxine (t4) replacement therapy. | 2000 | 11054982 |
| pre-steady state kinetics of bacteriophage t4 dam dna-[n(6)-adenine] methyltransferase: interaction with native (gatc) or modified sites. | the dna methyltransferase of bacteriophage t4 (t4 dam mtase) recognizes the palindromic sequence gatc, and catalyzes transfer of the methyl group from s:-adenosyl-l-methionine (adomet) to the n(6)-position of adenine [generating n(6)-methyladenine and s:-adenosyl-l-homocysteine (adohcy)]. pre-steady state kinetic analysis revealed that the methylation rate constant k(meth) for unmethylated and hemimethylated substrates (0.56 and 0.47 s(-1), respectively) was at least 20-fold larger than the over ... | 2000 | 11058118 |
| formation of cis-diamminedichloroplatinum(ii) 1,2-intrastrand cross-links on dna is flanking-sequence independent. | mapping of cis-diamminedichloroplatinum(ii) (cis-ddp, cisplatin) dna adducts over >3000 nucleotides was carried out using a replication blockage assay. the sites of inhibition of modified t4 dna polymerase, also referred to as stop sites, were analyzed to determine the effects of local sequence context on the distribution of intrastrand cisplatin cross-links. in a 3120 base fragment from replicative form m13mp18 dna containing 24.6% guanine, 25.5% thymine, 26.9% adenine and 23.0% cytosine, 166 i ... | 2000 | 11058123 |
| thyroid hormone changes in males exposed to lead in the buenos aires area (argentina). | the relationship between lead levels in blood (pbb) and hormones t3, t4, t4f and tsh were studied in 75 subjects exposed to lead at work. pbb levels in blood were determined by atomic absorption spectrophotometry and hormones by enzymoimmunoassay. positive and significant correlations among thyroid hormones and tsh vs blood lead level in the ranges 8-50 and 26-50 micro g dl(-1)were found ('r' between 0.304 and 0.621 and 0.431 and 0.619, respectively). at pbb levels between 8 and 26 micro g dl(-1 ... | 2000 | 11058414 |
| the relationship between thyroxine, oestradiol, and postnatal alopecia, with relevance to women's health in general. | post-partum hair loss is possibly due to a reduction in the levels of oestradiol and thyroxine postnatally. alopecia and/or a persistent loss of hair condition postnatally is associated with a group of symptoms (a syndrome), wherein postnatal depression is significant, as a result of physiologically inadequate levels of thyroxine (t4) and oestradiol (e2), secondary to physiological postnatal anterior pituitary dysfunction. using this hypothesis, the author began to apply the same hypothesis to o ... | 2000 | 11058426 |
| investigation of the relationship between low apgar scores and early neonatal thyroid function. | the aim of the present study was to assess the effects of low apgar scores on perinatal thyroid function. | 2000 | 11059541 |
| administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. | radioiodine (131i) is increasingly used as treatment for volume reduction of nontoxic, nodular goiter. a high dose of 131i is often needed because of low thyroid radioiodide uptake (raiu). we investigated whether pretreatment with a single, low dose of recombinant human tsh (rhtsh; thyrogen, genzyme transgenics corp.) enhances raiu in 15 patients with nontoxic, nodular goiter (14 women and 1 man; aged 61+/-11 yr). four patients were studied twice, and 1 patient was studied 3 times. raiu was meas ... | 2000 | 11061507 |
| detection of recurrent thyroid cancer by sensitive nested reverse transcription-polymerase chain reaction of thyroglobulin and sodium/iodide symporter messenger ribonucleic acid transcripts in peripheral blood. | to investigate whether circulating thyroglobulin (tg) messenger ribonucleic acid (mrna) and sodium/iodide symporter (nis) mrna transcripts in peripheral blood are valuable in the follow-up of patients with thyroid cancer, we developed highly sensitive nested tg and nis mrna detection assays and compared their accuracy with serum thyroglobulin (stg) and whole body scan with 131i during the monitoring of 34 patients with well differentiated thyroid carcinoma who had undergone total thyroidectomy ( ... | 2000 | 11061512 |
| circulating thyrotropin bioactivity in sporadic central hypothyroidism. | the etiopathogenesis of sporadic central hypothyroidism (ch) involves pituitary and hypothalamic lesions. pituitary ch (pch) implies a diminished number of functioning thyrotropes, accounting for the quantitative impairment of tsh secretion. hypothalamic ch (hch) is characterized by normal or even increased tsh concentrations and qualitative abnormalities of tsh secretion, including a decreased bioactivity of circulating tsh. however, controversy still exists about the actual occurrence of bioin ... | 2000 | 11061514 |
| a novel mutation causing complete thyroxine-binding globulin deficiency (tbg-cd-negev) among the bedouins in southern israel. | t4-binding globulin (tbg) is the major thyroid hormone transport protein in human serum. inherited tbg abnormalities do not usually alter the metabolic status and are transmitted in x-linked inheritance. a high prevalence of complete tbg deficiency (tbg-cd) has been reported among the bedouin population in the negev (southern israel). in this study we report a novel single mutation causing complete tbg deficiency due to a deletion of the last base of codon 38 (exon 1), which led to a frame shift ... | 2000 | 11061524 |
| hashimoto's thyroiditis: countrywide screening of goitrous healthy young girls in postiodization phase in india. | countrywide salt iodization, to prevent nutritional iodine deficiency, has been achieved in india recently. the current study was planned to evaluate the prevalence of goiter and thyroid autoimmunity and assess thyroid functional status in a cohort of 6283 healthy schoolgirls from different parts of the country in the postiodization phase. goitrous girls (n = 1810; 28% of subjects) were investigated for serum t4 and tsh, antithyroid microsomal antibody (tma) and antithyroglobulin antibody (tga), ... | 2000 | 11061541 |
| comparison of a linear miniature ultrasound probe and a radial-scanning echoendoscope in tn staging of esophageal cancer. | endoscopic ultrasonography is a precise method for tn staging of esophageal cancer. we explored the staging properties of a linear miniprobe as compared with a radial-scanning echoendoscope. | 2000 | 11063164 |
| localization of initial lymph node metastasis from carcinoma of the thoracic esophagus. | most surgeons consider esophageal carcinoma with lymph node involvement a systemic disease. however, it is possible that the disease may be localized in the earlier phases of lymphatic metastasis. the distribution of involved lesions in the initial phase of lymph node metastasis has not been thoroughly investigated yet. | 2000 | 11064342 |
| congruent spinopelvic alignment on standing lateral radiographs of adult volunteers. | radiographs of 75 healthy volunteers were measured to decide parameters and ranges for "congruent" sagittal spinopelvic alignments using the pelvic radius technique. a subset of 30 of the volunteers subsequently had a second radiograph to assess for changes in the repeated measurements. | 2000 | 11064527 |
| the perception of lexical tone in mambila. | the issue of the perception of lexical tone has been addressed mainly through studies of southeast asian languages which feature phonological contour tones as well as level tones. little attention has been paid to african languages which have, almost exclusively, only level tones. this paper examines tone perception in mambila, a benue-congo language with four level lexical tones. a categorization experiment was run to determine some of the salient aspects of the perceptual nature of these tones ... | 2000 | 11064955 |
| salvage radiotherapy for prostate cancer recurrence after cryosurgical ablation. | to retrospectively determine the outcome of patients treated with salvage three-dimensional conformal radiotherapy (rt) for prostate cancer recurrence after cryosurgical ablation of the prostate (csap). biochemical control rates and morbidity were analyzed. | 2000 | 11068312 |
| [clinical epidemiology of basedow's disease in belgium]. | graves' disease (gd) patients treated with antithyroid drugs (atd) have overall relapse rates of 30-50% after atd discontinuation. conflicting data have been reported with regard to the usefulness of adding thyroxine (i-t4) during and after atd treatment. also, clinicians are still in search of useful factors to predict remission/recurrence after atd withdrawal. eighty two consecutive patients were treated with atd for 15 months, combined with 12 months of i-t4. then, patients were randomized (p ... | 2000 | 11068483 |
| randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. | the objective of the present study was to assess the toxicology of melatonin (10 mg), administered for 28 days to 40 volunteers randomly assigned to groups receiving either melatonin (n = 30) or placebo (n = 10) in a double-blind fashion. the following measurements were performed: polysomnography (psg), laboratory examinations, including complete blood count, urinalysis, sodium, potassium and calcium levels, total protein levels, albumin, blood glucose, triglycerides, total cholesterol, high-den ... | 2000 | 11068941 |
| [the analysis of the selected epidemiological aspects in patients with inhalant allergy treated at the allergology outpatient clinic in zabrze]. | the study was designed to analyse the selected epidemiological aspects in patients with inhalant allergy treated at the allergology outpatient clinic in zabrze from 1989 till 1994. the analysis was based on the data from the files of 11,540 patients. the data of the pollinotic patients (1571 subjects) and of those with bronchial asthma (521 subjects) were analysed with regard to frequency of the diseases, place of residence (urban or country area), sex, date of birth, age when the illness had oc ... | 2000 | 11070761 |
| [operative stress during aorto-bifemoral reconstruction as dependent on a type of anesthesia]. | abdominal aortic reconstruction surgery in patients with arteriosclerosis obliterans usually has been carried out under standard intratracheal anaesthesia and only a some few centres have included continuous suprameningeal anaesthesia. on the basis of that scanty data it seems that combined intratracheal and suprameningeal anaesthesia might have some advantages over the standard anaesthesia owing to reducing general symptoms of perioperative stress. the aim of this study was to investigate the o ... | 2000 | 11070762 |
| prevention of renal cell carcinoma by active vitamin d3. | we studied the serum levels of 1,25-dihydroxyvitamin d [1,25(oh)2d (vit d)] in patients with renal cell carcinoma (rcc) and the influence of 1,25(oh)2d3 (vit d3) on gap junctional intercellular communication (gjic) during carcinogenesis. the serum vit d levels were measured by a competitive protein-binding assay using the chromatographic method. using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (mtt) assay, noncytotoxic concentrations of vit d3 and the tumor promoters n-ni ... | 2000 | 11071463 |
| squamous cell carcinoma of the oropharynx: ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy. | to assess the prognostic value of biologic (p53, ki-67) and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (rt). | 2000 | 11072161 |
| prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. | to evaluate the prognostic significance of postchemoradiation pathologic stage and implications for further therapy following preoperative chemoradiation and surgery for advanced/recurrent rectal cancer. | 2000 | 11072165 |
| bcmsun, a candidate gene for b-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, bcmsun-like. | the most frequent chromosomal imbalance in b-cell chronic lymphocytic leukemia (b-cll) and mantle-cell lymphoma (mcl) is loss of material from 13q14.3. bcmsun (previously leu2, t4, cdna 1b4) is one of 3 proposed candidate genes isolated from the minimally deleted region. we identified a homolog of bcmsun, termed bcmsunl (for bcmsun-like). radiation-hybrid mapping with a pcr-amplified fragment and fluorescence in situ hybridization with 2 pac clones containing coding information for bcmsunl revea ... | 2000 | 11072235 |
| high complete pathological response in locally advanced breast cancer using paclitaxel and cisplatin. | in an earlier study, we have demonstrated a high response rate in metastatic breast cancer using paclitaxel (p) and cisplatin (c). a phase ii study using the same regimen (pc) has been conducted in locally advanced breast cancer (labc). | 2000 | 11072788 |
| vasoactive intestinal polypeptide in rat heart atria: the effect of hyperthyroidism. | the effects of transient and sustained hyperthyroidism on vasoactive intestinal polypeptide-like immunoreactivity (vip-li) levels were studied in the heart atria of developing and adult rats. newborn rats were divided into 5 groups. neo-t animals were treated with thyroxine (t4) during postnatal days 1-8 and sacrificed at the age of 60 days. neo-s rats were treated with t4 during postnatal days 1-60 and sacrificed one day later. adult-1 and adult-2 animals received t4 during days 52-60 and were ... | 2000 | 11072802 |
| a novel mutation (m310l) in the thyroid hormone receptor beta causing resistance to thyroid hormone in a brazilian kindred and a neonate. | resistance to thyroid hormone (rth) is an inherited syndrome of reduced tissue responsiveness to thyroid hormone (t3) caused by mutations in the thyroid hormone receptor beta (trbeta). the index patient of the family reported here, a 17-year-old woman, came to medical attention because of a diffuse goiter, short stature, and learning disabilities. biochemical tests revealed an elevated free t4 of 5.2 ng/dl (0.8-2.1), a t3 of 270 ng/dl (80-220), and a nonsuppressed tsh of 1.79 mu/l (0.4-4). admin ... | 2000 | 11073720 |
| virus mutators and antimutators: roles in evolution, pathogenesis and emergence. | virus mutators (mutant alleles that confer a higher mutant-frequency phenotype than that of the wild type) and antimutators (mutant alleles that confer a lower mutant-frequency phenotype) were discovered in bacteriophage t4 over three decades ago, but there is only limited detailed knowledge about such genetic variants in viruses that infect humans and threaten public health. the creation of mutators and antimutators during the course of viral infection (particularly in the case of rna viruses) ... | 2000 | 11074294 |
| the effect of atrazine on puberty in male wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. | since atrazine (atr), a chlorotriazine herbicide, has been shown previously to alter the secretion of luteinizing hormone (lh) and prolactin (prl) through a direct effect on the central nervous system (cns), we hypothesized that exposure to atr in the edstac male pubertal protocol (juvenile to peripubertal) would alter the development of the male rat reproductive system. we dosed intact male wistar rats from postnatal day (pnd) 23 to 53 and examined several reproductive endpoints. atr (0, 12.5, ... | 2000 | 11053540 |
| bilateral open treatment of spontaneous pneumothorax: a new access. | a new technique for bilateral apical bullectomy and pleurectomy via axillary minithoracotomy and transmediastinal access to the contralateral side, was used in 13 patients with bilateral apical blebs and/or pneumothorax. the contralateral space is reached at the posterior superior mediastinum, passing between the first thoracic vertebral bodies (t1-t4) and the oesophagus. the contralateral lung apex is then pulled into the thoracotomy side and apical bullectomy carried out by linear stapler. the ... | 2000 | 11053826 |
| modeling hiv transfer between dendritic cells and t cells: importance of hiv phenotype, dendritic cell-t cell contact and t-cell activation. | to study the requirements for hiv transfer between dendritic cells (dc) and cd4 t cells, using an in vitro model, combined with flow cytometry. | 2000 | 11089618 |
| analysis of the okazaki fragment distributions along single long dnas replicated by the bacteriophage t4 proteins. | rolling circle replication from m13 dna circles was previously reconstituted in vitro using purified factors encoded by bacteriophage t4. the products are duplex circles with linear tails >100 kb. when t4 dna polymerase deficient in 3' to 5' exonuclease activity was employed, electron microscopy revealed short single-stranded dna "flaps" along the replicated tails. this marked the beginning of each okazaki fragment, allowing an analysis of the lengths of sequential okazaki fragments on individua ... | 2000 | 11090619 |
| the structure of udp-n-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. | bacterial udp-n-acetylglucosamine 2-epimerase catalyzes the reversible epimerization at c-2 of udp-n-acetylglucosamine (udp-glcnac) and thereby provides bacteria with udp-n-acetylmannosamine (udp-mannac), the activated donor of mannac residues. mannac is critical for several processes in bacteria, including formation of the antiphagocytic capsular polysaccharide of pathogens such as streptococcus pneumoniae types 19f and 19a. we have determined the x-ray structure (2.5 a) of udp-glcnac 2-epimera ... | 2000 | 11106477 |
| the role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase. | human type 2 iodothyronine deiodinase (hd2) catalyzes the activation of t4 to t3. d2, like types 1 and 3 deiodinases, contains selenocysteine (sec) in the highly conserved active center at position 133. to evaluate the contribution of sec133 to the catalytic properties of hd2, we generated mutants in which cysteine (cys) or alanine (ala) replaced sec133. the km (t4) of cys133d2 was 2.1 microm, strikingly higher than that of native d2 (1.4 nm). in contrast, the relative turnover number was 10-fol ... | 2000 | 11108274 |
| [therapy concept in differentiated thyroid gland carcinoma--results of 25 years with 257 patients]. | differentiated thyroid carcinoma is a unique tumour in that a low risk-patient population with a tumour-related death rate of near 0% can be found. yet in these patients the risk and risk factors of curable recurrences must be considered. the question therefore arises, whether in defined subgroups of low risk-patients a reduced extent of treatment (hemithyroidectomy, total thyroidectomy without 131i ablation) may result in cure without recurrence, including low morbidity of treatment and reduced ... | 2000 | 11109916 |
| thyroid function in very-low-birth-weight infants with intraventricular hemorrhage. | the objective of this investigation was to study the natural course of thyroid function in infants with intraventricular hemorrhage (ivh). a cohort of infants < 1,500 grams birth weight, n=247, were included in the analysis. total t4 and thyrotropin from newborn screening during the 1st week of life (test 1) and from repeat screening at 2-4 weeks postnatal age (test 2) were compared in infants with ivh (n=43) and a group of infants without ivh. fifty-nine percent of infants still had transient h ... | 2000 | 11110365 |
| nuclear morphometry for the prediction of regional lymph nodes metastases in patients with cancer of the larynx. | the changes in cell nuclei reflect their activity. quantitative morphometric analyses of tumor nuclei could be instrumental in providing prognostic information. we studied whether, and if so, which specific nuclear parameters and histoclinical factors in patients with cancer of the larynx could be related to the lymph node metastases. specimens were taken from 61 patients surgically treated in the department of otolaryngology, jagiellonian university, cracow, poland, between 1987 and 1988. the p ... | 2000 | 11112977 |
| short-term effects of fiberotomy on relapse of anterior crowding. | the effects of fiberotomy were evaluated in alleviating dental relapse of incisors after orthodontic treatment. the study sample consisted of 23 patients with crowded maxillary and mandibular incisors before orthodontic treatment. the amount of initial crowding was determined according to little's irregularity index. fiberotomy procedures were performed on 11 of the patients 1 week before debonding. the other 12 subjects served as the control group. all patients wore hawley retainers. lateral ce ... | 2000 | 11113795 |
| genetic analysis of bacteriophage-encoded cochaperonins. | early genetic studies identified the escherichia coli groes and groel genes because mutations in them blocked the growth of bacteriophages lambda and t4. subsequent genetic and biochemical analyses have shown that groes and groel constitute a chaperonin machine, absolutely essential for e. coli growth, because it is needed for the correct folding of many of its proteins. in spite of very little sequence identity to groes, the bacteriophage t4-encoded gp31 protein and the bacteriophage rb49-encod ... | 2000 | 11092834 |
| accelerated growth signals and low tumor-infiltrating lymphocyte levels predict poor outcome in t4 esophageal squamous cell carcinoma. | little is known about the biological nature of t4 esophageal carcinoma growth signals and host defenses. | 2000 | 11093500 |
| renal excretion and saline intake during post-stress immobilization period in rats. | an experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. a saline solution for 3 days was provided to the rats previous to the experimental day. on that day, after finishing acute immobilization stress, all variables under observation were measured every 6 h for 24 h. these periods were denominated as follows: t1 (12.00 to 18.00 h), t2 (18.00 to ... | 2000 | 11094380 |
| revised t3 uptake and t4-to-t3 conversion in brain and cerebellum of 10-day-old rats: a compartment analysis. | the peripheral and cerebral metabolism of thyroid hormones in 10-day-old rats was evaluated by measuring the kinetics of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) fluxes. labeled iodo-compounds were measured in the plasma, cerebellum and brain (without cerebellum) for 24 hours after the intravenous injection of [125i]t4 plus [131i]t3. data were interpreted by compartment analysis. t4 was produced at 8.93 pmol x h(-1) and t3 at 2.26 pmol x h(-1) for 22.7 g body weight. the t4 and t3 distrib ... | 2000 | 11094382 |
| is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? | several recent publications have drawn attention to the role of the thyroid hormone status of the mother on the future neuropsychological development of the child. the screening of pregnant women for clinical or subclinical hypothyroidism based on second trimester elevated maternal tsh values has been proposed. here, we have summarized present epidemiological and experimental evidence strongly suggesting that conditions resulting in first trimester hypothyroxinemia (a low for gestational age cir ... | 2000 | 11095417 |
| a characteristic serpin cleavage product of thyroxine-binding globulin appears in sepsis sera. | t4-binding globulin (tbg), the principal thyroid hormone-binding protein of serum, is a member of the serine protease inhibitor (serpin) superfamily. we report a characteristic serpin cleavage product of tbg in sepsis sera. at 49-50 kda, the tbg remnant is 4-5 kda smaller than the intact protein and is the same molecular mass as a tbg cleavage product produced by incubation with polymorphonuclear elastase. incubation with polymorphonuclear leukocytes also produces the 49- to 50-kda remnant, and ... | 2000 | 11095421 |
| persistent increase in bone turnover in graves' patients with subclinical hyperthyroidism. | hyperthyroid patients exhibit accelerated bone loss by increased bone turnover, and normalization of thyroid function is associated with a significant attenuation of increased bone turnover, followed by an increase in bone mineral density. however, of patients with graves' disease (gd) maintained on antithyroid drug (atd) treatment, some exhibit persistent suppression of tsh long after normalization of their serum free t3 (ft3) and free t4 (ft4) levels. the aim of this study was to examine wheth ... | 2000 | 11095447 |
| the effect of droloxifene and estrogen on thyroid function in postmenopausal women. | estrogen is known to increase serum t4-binding globulin (tbg) concentrations, thereby increasing serum total t4 concentrations. serum free t4 concentrations, however, remain normal. tamoxifen, a selective estrogen receptor modifier (serm), also raises serum tbg concentrations, but whether newer serms with less stimulatory action on the endometrium do so is not known. we, therefore, compared the effect of droloxifene, a serm, and conjugated equine estrogen on pituitary-thyroid function in normal ... | 2000 | 11095487 |
| nucleotide-sequence-specific and non-specific interactions of t4 dna polymerase with its own mrna. | the dna-binding dna polymerase (gp43) of phage t4 is also an rna-binding protein that represses translation of its own mrna. previous studies implicated two segments of the untranslated 5'-leader of the mrna in repressor binding, an rna hairpin structure and the adjacent rna to the 3' side, which contains the shine-dalgarno sequence. here, we show by in vitro gp43-rna binding assays that both translated and untranslated segments of the mrna contribute to the high affinity of gp43 to its mrna tar ... | 2000 | 11095675 |
| steroid concentrations in follicular fluid aspirated repeatedly from transitional and cyclic mares. | the objectives of the present study were to determine follicular progesterone (p4) and estradiol-17beta (e2) in transitional mares and to compare follicular steroid concentrations between transitional and cyclic mares. follicles > 8 mm were aspirated under transvaginal ultrasound-guidance 4 times at 3 to 4 day intervals (t1-t4) in norwegian pony mares during vernal transition. during the breeding season, follicular aspirations were conducted in each mare on day 6, day 14 and day 18 after ovulati ... | 2000 | 11097041 |
| [role of lymph nodes in rectal carcinoma]. | the significance of the lymph nodes for the therapy and the prognostics of the rectal cancer are reviewed. not only the depth of penetrations, but the probability of lymph node involvement (in our series tumors staged t1 had in 12% positive lymph nodes, t2 in 20% respectively, t3 in 37% and t4 in 80%) determine the possible surgical treatment. the available data of different techniques in lymphadenectomy and lymph node staging are compared and discussed. the aim of this paper is to give the onco ... | 2000 | 11098582 |
| primary percutaneous approach to upper urinary tract transitional cell carcinoma. | the optimal approach to upper tract tcc remains to be redefined. a routine nephroureterectomy for every filling defect in the upper urinary system, even in the case of a normal contralateral kidney, constitutes an unnecessary mutilation in more than two thirds of the cases. nephroureterectomy does not reduce the need for a long-term cystoscopic follow-up because of the high rate of bladder tumor recurrence that may happen years later after nephroureterectomy. relying solely on radiography and cy ... | 2000 | 11098771 |
| effects of amplification facilitators on diagnostic pcr in the presence of blood, feces, and meat. | the full potential of diagnostic pcr is limited, in part, by the presence of inhibitors in complex biological samples that reduce the amplification efficiency. therefore, different pre-pcr treatments are being used to reduce the effects of pcr inhibitors. the aim of the present study was to investigate the effects of 16 amplification facilitators to enhance dna amplification in the presence of blood, feces, or meat. different concentrations of amplification facilitators and inhibitory samples we ... | 2000 | 11101581 |
| [significance of neoadjuvant chemotherapy for gastric cancer]. | neoadjuvant chemotherapy for high-risk patients with advanced gastric cancer is important to increase the chance for curative resection and make unresectable gastric cancer tumors resectable by down-staging of the tumor. tumors with h0, p0, t3, t4, or n3 are the best candidates for this therapy. randomized controlled phase iii studies are needed in conjunction with accurate staging of the disease by laparoscopy. the results of histopathologic evaluation of resected materials following preoperati ... | 2000 | 11103233 |
| rna polymerase--promoter recognition. specific features of electrostatic potential of "early" t4 phage dna promoters. | comparative analysis of electrostatic potential distribution for "early" t4 phage promoters was undertaken, along with calculation of topography of electrostatic potential around the native and adp-ribosylated c-terminal domain of rna polymerase alpha-subunit. the data obtained indicate that there is specific difference in the patterns of electrostatic potential distribution in far upstream regions of t4 promoters differing by their response to adp-ribosylation of rna polymerase. a specific chan ... | 2000 | 11149509 |
| stabilization of proteins by enhancement of inter-residue hydrophobic contacts: lessons of t4 lysozyme and barnase. | although the hydrophobic interactions are considered as the main contributors to the protein stability, not much examples of protein stabilization by rational increasing of this type of interactions still can be found in literature. this is partly due to the lack of proper theoretical "measure" of hydrophobic interactions and their changes upon mutations. in the present paper the molecular hydrophobicity potential approach is used to assess how the changes in type and the strength of inter-resid ... | 2000 | 11149522 |
| exploring steric constraints on protein mutations using mage/probe. | when planning a mutation to test some hypothesis, one crucial question is whether the new side chain is compatible with the existing structure; only if it is compatible can the interpretation of mutational results be straightforward. this paper presents a simple way of using the sensitive geometry of all-atom contacts (including hydrogens) to answer that question. the interactive mage/probe system lets the biologist explore conformational space for the mutant side chain, with an interactively up ... | 2000 | 11152136 |
| subclinical hyperthyroidism and the risk of dementia. the rotterdam study. | aims and subjects: we investigated the prospective relationship between thyroid status and the risk of dementia and alzheimer's disease among a random sample of 1843 participants, aged 55 years and over, from the population-based prospective rotterdam study. | 2000 | 11155096 |
| thyroid disease in hcv carriers undergoing antiviral therapy with interferon plus ribavirin. | high prevalence of thyroid autoantibodies, with or without overt thyroiditis, has been described in hepatitis c patients, particularly in those undergoing alpha-interferon treatment. the aim of this study was to describe the frequency and clinical outcome of thyroid disease in a cohort of hcv carriers before and during combination therapy with interferon plus ribavirin. between may, 1997, and may, 1999, 111 previously untreated (naive) patients were treated with a-interferon plus ribavirin for 6 ... | 2000 | 11136525 |
| autoimmune thyroiditis with severe hypothyroidism resistant to the treatment with high peroral doses of thyroxine: case report. | female patient (42 yr) suffered from autoimmune thyroiditis resulting in severe hypothyroidism. she was treated for several years by district physician with the dose of 150 microg l-thyroxine daily. since the level of tsh was repeatedly very high and no improvement of clinical signs has been observed, she was referred to the medical faculty hospital. thyroid ultrasound showed remarkable diffuse hypoechogenicity, thyroid scintigraphy showed enlarged thyroid with low 99mtc uptake, trh test was nor ... | 2000 | 11137979 |