Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| inflammatory predictors of mortality in the scandinavian simvastatin survival study. | the predictive value of specific markers of infection and autoimmunity for coronary events, such as the effects of statins on inflammation, is still controversial. | 2002 | 12375804 |
| infectious background of patients with a history of acute anterior uveitis. | to study the infectious background of patients with a history of acute anterior uveitis (aau) and healthy control subjects. | 2002 | 12379526 |
| selection of mutant cell lines resistant to infection by chlamydia spp [corrected]. | the lytic outcome of natural infection by chlamydia trachomatis was exploited to select cho (chinese hamster ovary) cells, following chemical mutagenesis, that were deficient in their ability to sustain productive chlamydial infection. four distinct mutant cell phenotypes with defects in either attachment or postattachment mechanisms that are required for infection by c. trachomatis and chlamydia pneumoniae were characterized. | 2002 | 12379725 |
| a new family of highly variable proteins in the chlamydophila pneumoniae genome. | chlamydiaceae are obligate intracellular bacterial pathogens characterized by a wide range of vertebrate host, tissue tropism and spectrum of diseases. to get insights into the biological mechanisms involved in these differences, we have put forward a computational and experimental procedure to identify the genome recombination hotspots, as frequent sequence variation allows rapid adaptation to environmental changes. we find a larger potential for recombination in chlamydophila pneumoniae genome ... | 2002 | 12384581 |
| treatment of chlamydia pneumoniae infection and chronic obstructive pulmonary disease. | chronic obstructive lung disease (copd) is a general term for chronic, irreversible lung disease that combines qualities of emphysema and chronic bronchitis. the standard definition of chronic bronchitis is a productive cough for three months per year (for at least two consecutive years) without an underlying aetiology. acute exacerbation of chronic bronchitis (aecb) represents a common complaint that leads patients to seek medical attention. copd and aecb are directly responsible for the overus ... | 2002 | 12387692 |
| chlamydia pneumoniae in community-acquired pneumonia: seven years of experience. | to determine the prevalence of chlamydia pneumoniae in community-acquired pneumonia during a period of seven years. | 2002 | 12387767 |
| a casuistic immunologic response in primary and repeated chlamydophila pneumoniae infections in an immunocompetent individual. | a casuistic immunologic response in primary and repeated chlamydophila pneumoniae infection is described. the primary c pneumoniae infection was documented as laboratory accident in late 1990. the immunologic response was mediated mainly through production of igm antibodies with only a marginal igg and iga increase near the cut-off value. the second episode of respiratory illness in the summer of 1999 that was clinically compatible with acute c. pneumoniae infection was characterised by only inc ... | 2002 | 12387780 |
| cefditoren, a new aminothiazolyl cephalosporin. | cefditoren pivoxil, an oral third-generation cephalosporin, was approved by the food and drug administration in september 2001. it has been used in japan for several years. the greatest therapeutic potential of cefditoren appears to be its activity against gram-positive and gram-negative organisms causing respiratory tract infections and skin and skin-structure infections, such as haemophilus influenzae, streptococcus pneumoniae, and moraxella catarrhalis. cefditoren is also effective against me ... | 2002 | 12389878 |
| prevalence of antibody to chlamydia pneumoniae in residents of japan, the solomon islands, and nepal. | sera of 4,050 residents from japan, 276 from the solomon islands, and 602 from nepal were tested by an enzyme-linked immunosorbent assay to determine the prevalence of antibody to chlamydia pneumoniae. the prevalence of igg and iga antibodies was significantly higher in the solomon islands (64.9% and 82.2%) and nepal (73.1%, and 69.8%) than in japan (53.6% and 41.1%). these prevalence rates increased throughout the teenage years in the solomon islands and japan and leveled off with age, whereas ... | 2002 | 12389943 |
| chronic obstructive pulmonary disease: role of bacteria and guide to antibacterial selection in the older patient. | chronic obstructive pulmonary disease (copd) is a common problem in the elderly. the disease is characterised by intermittent worsening of symptoms and these episodes are called acute exacerbations. the best estimate, based on several lines of evidence, is that approximately half of all exacerbations are caused by bacteria. these lines of evidence include studies of lower respiratory tract bacteriology during exacerbations, correlation of airways' inflammation with results of sputum cultures dur ... | 2002 | 12390053 |
| does infection with chlamydia pneumoniae and/or helicobacter pylori increase the expression of endothelial cell adhesion molecules in humans? | to investigate if chlamydia pneumoniae and/or helicobacter pylori seropositivity is associated with elevated levels of soluble endothelial cell adhesion molecules (scams) as markers of atherosclerotic activity. | 2002 | 12390284 |
| [community-acquired pneumonia, acute respiratory distress syndrome, and severe sepsis due to chlamydia pneumoniae]. | 2002 | 12392655 | |
| the association of seropositivity to helicobacter pylori, chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study. | we sought to determine whether seropositivity to helicobacter pylori, chlamydia pneumoniae, and cytomegalovirus (cmv) is an independent predictor of incident cardiovascular disease. | 2002 | 12392829 |
| chlamydia pneumoniae inside the atherosclerotic plaque--does it affect plaque inflammation and plaque progression? | 2002 | 12393086 | |
| chlamydophila pneumoniae (chlamydia pneumoniae) accelerates the formation of complex atherosclerotic lesions in apo e3-leiden mice. | atherosclerosis is an inflammatory process and is characterised by the presence of t-lymphocytes in the lesions. to study the role of chlamydophila pneumoniae (c. pneumoniae) in this process and the effect of infection on t-cell influx, we infected apo e3-leiden mice with c. pneumoniae and investigated the effect on lesion development and t-cell influx in atherosclerotic lesions at different time points post infection (pi). | 2002 | 12393097 |
| chlamydia pneumoniae infections prevent the programmed cell death on thp-1 cell line. | chlamydia pneumoniae is an obligate intracellular bacterium which frequently causes airway infection in humans and has been implicated in chronic inflammatory disease and atherosclerosis. here we show that infection with c. pneumoniae protects thp-1 cells against the apoptosis which spontaneously occurs in macrophages in the absence of an activation signal. analysis by flow cytometry at different post-infection times revealed that 50+/-7% of thp-1 cells were apoptotic at 48 h after onset of the ... | 2002 | 12393203 |
| kn-62 enhances chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection. | chlamydia pneumoniae elementary bodies were demonstrated to increase the proliferation of murine fibroblast cell line l-929 and rapidly activate p44/p42 mitogen-activated protein kinase (mapk) in a protein kinase c (pkc) and protein kinase a (pka)-independent way. ca(2+)/calmodulin-dependent protein kinase (cam kinase) inhibitor kn-62 significantly enhanced c. pneumoniae-induced mapk phosphorylation, suggesting negative control of cam kinase pathway on the mapk cascade. in in vitro infection ass ... | 2002 | 12393215 |
| [chronic pharyngitis and macrolides]. | we have noticed that macrolides can improve the main symptoms of many patients with chronic pharyngitis. we feel that the efficacy of macrolides for chronic pharyngitis can be due to the anti-inflammatory effect of this group of antibiotics. however, we think that at present the use of macrolides is not the therapy of choice for chronic pharyngitis. | 2002 | 12402495 |
| atherosclerosis: lipid infiltration or chlamydia pneumoniae infection? | 2002 | 12403680 | |
| chlamydial heat-shock protein-60 antibody and correlation with chlamydia pneumoniae in atherosclerotic plaques. | a study was performed to determine whether serum antibody to chlamydial heat-shock protein-60 (chsp-60) and c-reactive protein (crp) were associated with the presence of chlamydia pneumoniae in atheromatous plaques in 75 patients. the mean (+/-sd) elisa optical density (od) of anti-chsp-60 was 0.19+/-0.15 in 54 patients with detectable c. pneumoniae antigen, versus an od of 0.11+/-0.08 in 21 patients without detectable c. pneumoniae i antigen (p=.008). higher anti-chsp-60 at an od > or =0.12 was ... | 2002 | 12404163 |
| procoagulant and inflammatory response of virus-infected monocytes. | monocytes play a prominent role in inflammation, coagulation and atherosclerosis by their ability to produce tissue factor (tf) and cytokines. the aim of the present study was to establish whether virus-infected monocytes initiate coagulation. in addition, the production of cytokines by monocytes may accelerate the chronic process of atherosclerosis and may contribute to coronary syndromes by eliciting plaque instability. | 2002 | 12406025 |
| molecular detection and seroepidemiology of the chlamydia pneumoniae bacteriophage (phicpn1). | recent whole-genome analysis has demonstrated limited genetic variation in chlamydia pneumoniae, with one strain (ar39) containing a 4,524 nucleotide single-stranded dna bacteriophage, phicpn1. using pcr, reverse transcription (rt)-pcr, and western blotting, we confirmed the presence and functional expression of phicpn1 in c. pneumoniae strain ar39 and its absence in strain cwl029. six additional epidemiologically distinct clinical isolates of c. pneumoniae also did not contain phicpn1. we gener ... | 2002 | 12409367 |
| impact of infectious burden on progression of carotid atherosclerosis. | recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. the extent of atherosclerosis and the prognosis of patients with atherosclerosis seem to be increased by the number of infections to which an individual has been exposed. in a prospective study, we evaluated the effect of 8 pathogens and the aggregate pathogen burden on the progression of carotid atherosclerosis. | 2002 | 12411646 |
| leukocyte count is associated with aortic arch plaque thickness. | leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies. we hypothesized that white blood cell count is associated with aortic arch plaque thickness (aapt). | 2002 | 12411647 |
| chlamydia pneumoniae immunoglobulin a reactivation and airway inflammation in acute asthma. | infection with chlamydia pneumoniae can trigger acute asthma and is associated with severe chronic asthma. the aim of the present study was to examine the relationship between airway inflammation and serological response to c. pneumoniae in acute severe asthma. subjects (n=54) were recruited within 4 h of presentation to the emergency department with an acute exacerbation of asthma. clinical history taking, sputum induction (0.9% saline), spirometry and acute and convalescent serology for c. pne ... | 2002 | 12412672 |
| comparative study of the presence of chlamydia pneumoniae in cerebrospinal fluid of patients with clinically definite and monosymptomatic multiple sclerosis. | there is considerable controversy concerning the evidence for the presence of chlamydia pneumoniae in the cerebrospinal fluid (csf) of both multiple sclerosis (ms) patients and patients with other neurological diseases (ond). in order to clarify this issue, the laboratories at vanderbilt university medical center (vumc) and the university of south florida (usf) examined the reproducibility of their respective pcr assays for the detection of c. pneumoniae dna in the csf of a common group of ms pa ... | 2002 | 12414770 |
| oro-dental bacteria in various atherosclerotic arteries. | chlamydia pneumoniae dna has been detected in at least 40% of all major arteries affected by atherosclerosis, but several other microorganisms have also been detected. in this study, diseased vessels were evaluated for the presence of the dna of seven oro-dental bacteria and two nonoral bacteria. a polymerase chain reaction technique was employed using primer pairs based on 16s rrna genes. of 32 specimens tested, 10 (31.2%) were dna positive: seven for actinobacillus actinomycetemcomitans and th ... | 2002 | 12415477 |
| [acute chlamydial lesions of the nervous system: etiology, diagnosis, clinical aspects]. | the examination of 180 patients with acute neuroinfection (105 males, 75 females at the age from 18 to 45 years) has detected c. trachomatis in 23.8%, c. pneumoniae in 66.6%, c. psittaci in 9.5% patients. acute and chlamydial lesions of the central nervous system were characterized by all forms of neuroinfection: serous and purulent meningitides, meningoencephalitides. development of acute neuroinfection is accompanied by sluggish chlamydial infection of the viscera. | 2002 | 12416222 |
| chlamydia pneumoniae-atherosclerosis link: a sound concept in search for clinical relevance. | 2002 | 12417534 | |
| reduced progression of early carotid atherosclerosis after antibiotic treatment and chlamydia pneumoniae seropositivity. | chlamydia pneumoniae (cp) infection has been associated with atherosclerosis, and a beneficial effect of antibiotic therapy on future cardiovascular events was described. | 2002 | 12417538 |
| treating chlamydia pneumoniae in patients with early atherosclerosis. | 2002 | 12417556 | |
| [chronic chlamydia pneumoniae infection in patients with coronary disease. relation with increased fibrinogen values]. | a number of studies have suggested that infection with chlamydia pneumoniae can play a role in development of atherosclerosis. the goal of this study was to know the prevalence of chronic c. pneumoniae infection, evaluated with igg antibodies seropositivity, in spanish patients with coronary disease and its association with inflammatory markers and cardiovascular risk factors. | 2002 | 12421506 |
| chlamydia pneumoniae antigens facilitate experimental aortic dilatation: prevention with azithromycin. | the purpose of this study was to investigate whether chlamydia pneumoniae (live, antigens, or polysaccharide) cause abdominal aortic aneurysm in a susceptible animal host with appropriate drug reversal. | 2002 | 12422113 |
| prevalence of chlamydia pneumoniae in nonrheumatic stenotic aortic valves. | 2002 | 12422163 | |
| high oxidized ldl and elevated plasma homocysteine contribute to the early reduction of myocardial flow reserve in healthy adults. | impairment of coronary blood flow reserve has been shown to be an early manifestation of atherosclerosis and coronary artery disease (cad). we studied more closely the contribution of various risk factors on early deterioration of coronary function. | 2002 | 12423319 |
| serial passage of chlamydia spp. in sub-inhibitory fluoroquinolone concentrations. | we investigated the in vitro development of fluoroquinolone resistance in chlamydia trachomatis and chlamydia (chlamydophila) pneumoniae grown in mccoy cell monolayers in supplemented eagle's minimum essential medium. with c. trachomatis, initial passages at sub-inhibitory fluoroquinolone concentrations did not affect fluoroquinolone susceptibility. however, after an initial lag of 10-24 passages (depending upon the fluoroquinolone used), fluoroquinolone resistance developed rapidly. the final f ... | 2002 | 12003968 |
| effect of gemifloxacin on viability of chlamydia pneumoniae (chlamydophila pneumoniae) in an in vitro continuous infection model. | persistent infection with chlamydia pneumoniae (chlamydophila pneumoniae) has been implicated in the development of atherosclerosis, asthma and other chronic diseases. however, data on treatment of c. pneumoniae infections are limited. microbiological failure of antimicrobial therapy has been described, even after prolonged courses of treatment with azithromycin, doxycycline and erythromycin. gemifloxacin is an enhanced-affinity fluoroquinolone with excellent activity against most common respira ... | 2002 | 12003969 |
| novel pcr-eia method for the detection of chlamydia pneumoniae in respiratory specimens. | we report the development of a microtitre plate-based pcr-eia assay (elaha; enzyme linked amplification and hybridization assay) for the sensitive and specific detection of chlamydia pneumoniae in sputum samples from patients with chronic obstructive airways disease (coad). following pcr amplification of a segment of the chlamydial heat shock 60 protein gene, the 587 bp sized amplicon is captured onto the streptavidin coated surface of a microtitre plate using a c. pneumoniae specific biotinylat ... | 2002 | 12005448 |
| experimental chlamydia pneumoniae infection in nih/s mice: effect of reinoculation with chlamydial or cell preparation on culture, pcr and histological findings of lung tissue. | the cellular components present in chlamydial preparations may contribute to the course of the experimental infection. nih/s mice were inoculated and reinoculated intranasally with chlamydia pneumoniae or a cellular preparation. the mock inoculation induced only mild histological changes in the lungs, which possibly induced partial protection against subsequent c. pneumoniae infection and, when given as reinoculation, possibly reactivated the culture-negative infection as culture-positive. in ad ... | 2002 | 12009287 |
| latent adenovirus infection in copd. | we have concentrated on the adenovirus as the source of the heightened inflammatory response of the lungs of patients with copd. we have concentrated in particular on the responses to agents such as lipopolysaccharides and environmental particulates that contaminate the air we breathe, and we have accumulated evidence that the e1a gene of this virus could be the key player in this process. as other intracellular pathogens such as chlamydia pneumoniae have recently been implicated in the pathogen ... | 2002 | 12010848 |
| proteomic analysis of differentially expressed chlamydia pneumoniae genes during persistent infection of hep-2 cells. | recent data have shown that the respiratory pathogen chlamydia pneumoniae expresses an altered gene transcription profile during gamma interferon (ifn-gamma)-induced persistent infection in vitro. in the present study, we examined, by proteomics, expression of c. pneumoniae proteins labeled intracellularly with [(35)s]methionine/cysteine under normal conditions or ifn-gamma-mediated persistence. the identity of differentially expressed proteins during persistent infection was determined by match ... | 2002 | 12010987 |
| infections and asthma in children. | the temporal association of acute asthma exacerbations in children with viral infections such as rhinovirus, respiratory syncytial virus, and parainfluenza has been known for many years. recently, the contributions of infections to the pathophysiology of asthma have been expanded beyond disease exacerbation to include disease inception, chronicity, and even prevention. respiratory syncytial virus has been implicated in asthma inception, while chlamydia pneumoniae, mycoplasma pneumoniae, and late ... | 2002 | 12011675 |
| 3: community-acquired pneumonia. | community-acquired pneumonia is caused by a range of organisms, most commonly streptococcus pneumoniae, mycoplasma pneumoniae, chlamydia pneumoniae and respiratory viruses. chest x-ray is required for diagnosis. a risk score based on patient age, coexisting illness, physical signs and results of investigations can aid management decisions. patients at low risk can usually be managed with oral antibiotics at home, while those at higher risk should be further assessed, and may need admission to ho ... | 2002 | 12013330 |
| [unfortunately without effectiveness: chlamydia eradication after infarct]. | 2002 | 12014269 | |
| mycoplasma pneumoniae and chlamydia pneumoniae cause lower respiratory tract disease in paediatric patients. | new studies suggest that mycoplasma pneumoniae and chlamydia pneumoniae play a more significant role as causes of lower respiratory tract infections in childhood than was previously thought. in particular, the incidence of infections caused by these pathogens is high in children aged less than 5 years, the infections themselves seem to be a possible cause of wheezing, and may present a more complicated course when not treated with adequate antimicrobial agents. however, despite the increasing pa ... | 2002 | 12015465 |
| chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-b: a potential link to intimal thickening in a rabbit model of atherosclerosis. | smooth muscle cell (smc) proliferation and intimal thickening are hallmark features of atherosclerotic disease, and chlamydia pneumoniae may contribute to atherogenesis by imparting biological effects on smcs. an in vitro endothelial cell model and a normocholesterolemic rabbit model were used to test the hypothesis that infection with c. pneumoniae induces smc growth factor production, smc proliferation, and aortic intimal thickening. using reverse-transcriptase polymerase chain reaction, it wa ... | 2002 | 12023768 |
| effect of macrolide antibiotics on human endothelial cells activated by chlamydia pneumoniae infection and tumor necrosis factor-alpha. | this study investigated the potential anti-inflammatory activity of 3 macrolide antibiotics, clarithromycin, roxithromycin, and azithromycin, in an in vitro model of transendothelial migration (tem). human umbilical vein endothelial cells (huvecs) were seeded in transwell inserts, treated with serial dilutions of the antibiotics, and infected with chlamydia pneumoniae or stimulated with tumor necrosis factor (tnf)-alpha. in huvecs infected with c. pneumoniae or stimulated with tnf-alpha, both az ... | 2002 | 12023769 |
| parachlamydiaceae: potential emerging pathogens. | parachlamydiaceae, which naturally infect amoebae, form a sister taxon to the chlamydiaceae on the basis of the chlamydia-like cycle of replication and 80% to 90% homology of ribosomal rna genes. because intra-amoebal growth could increase the virulence of some intracellular bacteria, parachlamydiaceae may be pathogenic. arguments supporting a pathogenic role are that chlamydia pneumoniae, a well-recognized agent of pneumonia, was shown to infect free-living amoebae and that another member of th ... | 2002 | 12023921 |
| chlamydia pneumoniae and the "dutch hypothesis". | 2002 | 12426243 | |
| comparison of individuals with and without specific iga antibodies to chlamydia pneumoniae: respiratory morbidity and the metabolic syndrome. | to determine whether a correlation exists between markers for persistent chlamydia pneumoniae infection, respiratory morbidity, and the metabolic syndrome. | 2002 | 12426257 |
| chlamydia pneumoniae and cardiovascular disease. | chlamydia pneumoniae has been detected in atherosclerotic plaques, while seropositivity to this organism confers a slightly increased risk of coronary events. however, no aetiological link has been established; a major difficulty when investigating this link is the lack of a gold standard for diagnosing chronic vessel infection. the outcomes of case-control studies and prospective trials of macrolides in treatment and prevention of cardiovascular disease have been ambiguous but suggest a short-t ... | 2002 | 12429006 |
| a chlamydia pneumoniae infection model using established human lymphocyte cell lines. | since current studies indicate possible infection of human lymphocytes with chlamydia (chlamydophila) pneumoniae, establishment of an in vitro c. pneumoniae infection model using lymphocyte cell lines was demonstrated. human lymphoid cell lines (molt 4 [t-cell] and p3hr1 [b-cell]) were utilized for this purpose besides human monocyte cell line (thp-1) and human epithelial cell line (hep-2), as a reference of monocyte/macrophage cells and a positive control for support of c. pneumoniae growth, re ... | 2002 | 12435507 |
| seroprevalence of igg antibodies against chlamydia pneumoniae in chinese, malays and asian indians in singapore. | chlamydia pneumoniae, a bacterium that causes respiratory infections, is probably under-diagnosed. there is also interest in its possible role in the aetiology of coronary heart disease. this is the first population-based seroprevalence survey of c. pneumoniae infection in singapore. | 2002 | 12435775 |
| lack of association between serum immunoreactivity and chlamydia pneumoniae detection in the human aortic wall. | only a few studies have focused the attention on the relation between elevated anti-chlamydia pneumoniae (cp) antibodies and the detection of cp in the arterial wall. the aim of our study is thus to investigate the relationship between immune response to cp and detection of cp in the aortic walls of patients with abdominal aortic aneurysm. | 2002 | 12438287 |
| influenza a and b igg seropositivity and coronary atherosclerosis assessed by angiography. | infectious agents, in particular intracellular pathogens that can establish long-term, persistent seropositivity, may play an important role in atherogenesis. the possible association between influenza type a and b infection and angiographically proven coronary artery disease (cad) and the effect of the aggregate pathogen burden on cad was studied by testing blood from 218 patients undergoing coronary angiography for serum igg antibodies to influenza a and b, and for antibodies to four other pat ... | 2002 | 12441011 |
| human herpesvirus 6 and chlamydia pneumoniae as etiologic agents in multiple sclerosis - a critical review. | multiple sclerosis (ms) is thought by many investigators to have an infectious component, and several microorganisms have been associated with the disease during the last three decades. recent studies have implicated both human herpesvirus 6 (hhv-6) and the obligate intracellular bacterium chlamydia pneumoniae in the etiology of ms. as with earlier studies of other potential agents, however, evidence linking either of these organisms to the disease is equivocal. in this article, we review data f ... | 2002 | 12443897 |
| chlamydia pneumoniae. | 2002 | 12445544 | |
| relationship of anti-60 kda heat shock protein and anti-cholesterol antibodies to cardiovascular events. | several recent studies have indicated an association between key inflammatory mediators and atherosclerotic diseases. we evaluated whether high levels of antibodies against heat shock proteins and cholesterol (acha) predicted cardiovascular (cv) events. | 2002 | 12451002 |
| adjuvant modulation of the immune responses and the outcome of infection with chlamydia pneumoniae. | immunization with different adjuvants resulted in antithetic outcomes of infection with chlamydia pneumoniae. immunization with the outer major protein-2 from c. pneumoniae (omp-2) emulsified in freund's complete adjuvant (fca) thus increased the susceptibility of mice to infection with the bacteria. the detrimental effect was not observed upon inoculation of irrelevant antigens or major outer membrane protein (momp) in fca, but was also observed after immunization with fca-chlamydial heat shock ... | 2002 | 12452828 |
| the expression, processing and localization of polymorphic membrane proteins in chlamydia pneumoniae strain cwl029. | chlamydiae are obligate intracellular bacteria, which are important human pathogens. genome sequences of c. trachomatis and c. pneumoniae have revealed the presence of a chlamydia specific gene family encoding polymorphic outer membrane proteins, pmps. in c. pneumoniae the family comprises twenty-one members, which are all transcribed. in the present study, the expression, processing and localisation of the sixteen full-length pmps in c. pneumoniae strain cwl029 have been further investigated by ... | 2002 | 12453305 |
| reliability of nested pcr for detection of chlamydia pneumoniae dna in atheromas: results from a multicenter study applying standardized protocols. | the present multicenter study was designed to find explanations for the discrepancies in the reported rates of detection of chlamydia pneumoniae dna in endarterectomy specimens. coded identical sets of (i) a c. pneumoniae dna dilution series (panel 1; n = 10), (ii) spiked control tissue specimens (panel 2; n = 10 specimens, including 5 negative controls), and (iii) endarterectomy specimens (panel 3; 15 atheromas, 5 negative controls) were analyzed at four laboratories by three standardized dna e ... | 2002 | 12454131 |
| chlamydia pneumoniae and copd exacerbation. | 2002 | 12454307 | |
| new parachlamydial 16s rdna phylotypes detected in human clinical samples. | chlamydiales are important intracellular bacterial pathogens, causing a wide variety of diseases in vertebrates, including humans. besides the well-known species in the family chlamydiaceae, new chlamydial organisms have recently been discovered, forming three new families: parachlamydiaceae, simkaniaceae and waddliaceae. parachlamydia acanthamoebae and simkania negevensis are currently investigated as emerging human respiratory pathogens. additional chlamydial lineages have been discovered by 1 ... | 2002 | 12455703 |
| elisa test to detect chlamydophila pneumoniae igg. | a new elisa test (chlamydophila pneumoniae igg, vircell, spain) to detect chlamydophila pneumoniae igg was evaluated. the micro-immunofluorescence (mif) test was used as reference method. chlamydia trachomatis and chlamydophila psittaci elementary bodies were also assayed. two hundred and sixteen sera were included in the study: 66 from patients with peripheral arterial occlusive disease (panel 1), 68 from adults with pneumonia (panel 2), 44 from healthy adults (panel 3) and 38 from patients wit ... | 2002 | 11925757 |
| chlamydia pneumoniae seropositivity and systemic and renovascular atherosclerotic disease. | patients with hypertension may be vulnerable to vascular chlamydia pneumoniae and/or cytomegalovirus (cmv) infection because of increased expression of adhesion molecules. | 2002 | 11926852 |
| chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy. | to determine whether igg antibodies to chlamydia pneumoniae are associated with nonarteritic ischemic optic neuropathy (naion). | 2002 | 11927434 |
| chlamydia pneumoniae, systemic inflammation and the risk of venous thrombosis. | inflammatory mediators are involved in activation of the coagulation system, and elevated plasma concentrations of il-6 and il-8 are associated with an increased risk of venous thrombosis. using serologic and molecular biologic tests, we investigated in a case-control study on patients with recurrent venous thrombosis the association between chlamydia (c) pneumoniae and venous thrombosis and we evaluated the relation between c. pneumoniae serology and the cytokines il-6 and il-8. the presence of ... | 2002 | 11929685 |
| non-lps components of chlamydia pneumoniae stimulate cytokine production through toll-like receptor 2-dependent pathways. | recent studies suggest that infection with chlamydia pneumoniae is associated with atherosclerosis, and that cytokines play an important role in the initiation and progression of chlamydia-induced inflammation. when freshly isolated peripheral blood mononuclear cells (pbmc) were stimulated for 24 h with sonicated c. pneumoniae, significant amounts of the pro-inflammatory cytokines tnf-alpha and il-1beta and of the anti-inflammatory cytokine il-10 were released into the supernatant. the addition ... | 2002 | 11932927 |
| characterisation of 20-kda lectin-spermagglutinin from arum maculatum that prevents chlamydia pneumoniae infection of l-929 fibroblast cells. | a novel lectin from the root of arum maculatum was isolated by saline extraction and purified by cold ethanol precipitation and subsequent fractionation on superose 6 column. the lectin named a. maculatum agglutinin is a non-glycosylated protein with 20-kda molecular mass agglutinating human ejaculated spermatozoa, but not human erythrocytes. the agglutination was blocked in the presence of n-acetylneuraminic acid indicating that the lectin is sialoglycoprotein specific. chlamydia pneumoniae str ... | 2002 | 11934571 |
| increased circulating immune complexes in acute stroke: the triggering role of chlamydia pneumoniae and cytomegalovirus. | the mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. the aim of this study was to examine the presence of immune complexes (ic) in the acute stroke setting and the first month thereafter and to characterize ic by analyzing the contents of chlamydial lipopolysaccharide and anti-cytomegalovirus (cmv) antibodies in ic. | 2002 | 11935040 |
| effect of azithromycin treatment on endothelial function in patients with coronary artery disease and evidence of chlamydia pneumoniae infection. | it has been suggested that infection with chlamydia pneumoniae(cpn) can trigger inflammatory mechanisms that may in turn impair vascular endothelial function. the aim of the present study was to assess whether treatment with the macrolide antibiotic azithromycin improves endothelial function in patients with coronary artery disease and antibodies positive to cpn. | 2002 | 11901039 |
| [does chronic periodontitis play a role in the pathogenesis of cardiovascular and cerebrovascular diseases?]. | the role of chronic infections in the initiation of atherosclerotic lesions has been vividly discussed in recent years. a possible causal relationship between cardiovascular diseases and infections with, e. g., chlamydia pneumoniae, helicobacter pylori, or herpes viruses had also been established for chronic periodontitis, in particular after discovery of dna of typical periodontal pathogens in atheromatous plaques. especially in longitudinal epidemiologic studies, a low or moderate association ... | 2002 | 11904848 |
| chlamydia pneumoniae iga- and igg antibodies in young survivors of myocardial infarction. a comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay. | chronic chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (mif) test. we wanted to investigate the c. pneumoniae iga- and igg seroprevalence in young survivors of myocardial infarction and matched controls, and to compare the agreement of detecting antibodies between a mif test and an enzyme immunoassay (eia). | 2002 | 11905590 |
| chlamydia pneumoniae and atherosclerosis -- what we know and what we don't. | the clinical manifestations of atherosclerosis include coronary artery disease (cad), stroke, abdominal aortic aneurysm and peripheral vascular disease. world-wide, cad and stroke are the leading causes of death and disability. the recognition of atherosclerosis as an inflammatory disease in its genesis, progression and ultimate clinical manifestations has created an interesting area of vascular research. apart from those well-known traditional risk factors for atherosclerosis, novel and potenti ... | 2002 | 11906495 |
| correlation of chlamydia pneumoniae infection and severity of accelerated graft arteriosclerosis after cardiac transplantation. | chlamydia pneumoniae has been associated with atherosclerosis, although its role in the process is not clearly defined. heart transplant recipients are known to have high titers of antibodies to c. pneumoniae, and the organism has been recovered from the coronary arteries of both transplant recipients and donors. this study evaluated association between c. pneumoniae infection and accelerated graft arteriosclerosis (aga), also known as cardiac allograft vasculopathy (cav), after cardiac transpla ... | 2002 | 11907424 |
| design of the pravastatin or atorvastatin evaluation and infection therapy (prove it)-timi 22 trial. | 2002 | 11909576 | |
| atypical pneumonia in children. | 2002 | 11910135 | |
| antibodies against chlamydia pneumoniae and their relation to lymphocyte population levels. | chlamydia pneumoniae infection has long been suspected as a possible cause of atherosclerosis and has been frequently detected in atheromatous plaques of the coronary arteries. nevertheless, its distribution is not correlated to the severity or extent of the disease, but it would support the hypothesis that the organism may be an active factor in the pathogenesis of atherosclerosis. a group of patients with stable angina were examined as to whether or not the positivity of antibodies against chl ... | 2002 | 11911918 |
| chlamydia pneumoniae dna in peripheral venous blood samples from patients with carotid artery stenosis. | in the study presented here, peripheral blood specimens obtained from patients with atherosclerosis were examined for the presence of chlamydia pneumoniae to determine whether these specimens can be used for routine testing. chlamydia pneumoniae dna was detected in 7 of 56 patients with carotid stenosis and in three of four patients with other atherosclerotic diseases, but it was not detected in any of 50 healthy controls or in any of 59 age- and gender-matched patients suffering from other nona ... | 2002 | 11913505 |
| properties of the glucose-6-phosphate transporter from chlamydia pneumoniae (hptcp) and the glucose-6-phosphate sensor from escherichia coli (uhpc). | the amino acid sequence of the proposed glucose-6-phosphate (glc6p) transporter from chlamydia pneumoniae (hptcp; hexose phosphate transporter [chlamydia pneumoniae]) exhibits a higher degree of similarity to the escherichia coli glc6p sensor (uhpc) than to the e. coli glc6p transporter (uhpt). overexpression of his-uhpc in a uhpt-deficient e. coli strain revealed that the sensor protein is also able to transport glc6p and exhibits an apparent k(m) ((glc6p)) of 25 microm, whereas his-hptcp exhib ... | 2002 | 11914341 |
| role of persistent infection in the control and severity of asthma: focus on chlamydia pneumoniae. | conventional risk factors have been unable to explain most of the substantial increase in the prevalence of asthma observed in many countries during the last few decades. much attention has been directed at the "hygiene hypothesis", the apparent inverse relationship between intense systemic childhood infections and the subsequent development of asthma and atopy. however, it is not only the absence or scarcity of infections, but the prolonged presence of certain microorganisms in the lungs that m ... | 2002 | 11936537 |
| no causal association between inflammation and chlamydia pneumoniae in patients with chronic ischemic arterial disease. | the c-reactive protein, chlamydia-specific igg antibody, and fibrinogen were assayed in the serum of 159 patients with arterial disease (the arterial group) and 203 patients with heart valve prostheses (the valvular group) and no demonstrable coronary disease. in the arterial group, the chlamydia pneumoniae antibody was > or = 1:32 for 67.3% (107/159) of the patients, the c-reactive protein was elevated in 41.5% (66/159), and the fibrinogen was elevated in 27.7% (44/159). in the valvular group, ... | 2002 | 11936753 |
| chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantation. | chlamydia pneumoniae is a common cause of upper and lower respiratory tract infections in immunocompetent patients; however, its role as a respiratory pathogen in immunocompromised hosts has been infrequently recognized. we describe c. pneumoniae lower respiratory tract infection in a 19-year-old male after allogeneic stem cell transplantation. the patient developed fever on day +14, and a subsequent computed tomography scan of the chest revealed a right lateral pleural-based opacity, which was ... | 2002 | 11923709 |
| chlamydia pneumoniae in infrequently examined blood vessels. | to determine the prevalence of chlamydia pneumoniae dna in infrequently examined blood vessels. | 2002 | 11896076 |
| mycoplasma and chlamydia pneumonia in pediatrics. | mycoplasma pneumoniae and chlamydia pneumoniae are common respiratory pathogens in children 5 years of age and older. although distinctly different in structure, these organisms share similar epidemiologic and clinical characteristics in human infection and disease. pneumonia caused by these organisms usually occurs after infection of the upper respiratory tract, but may occur in the absence of antecedent upper respiratory infection. diagnosis of infection with c. pneumoniae and m. pneumoniae is ... | 2002 | 11891514 |
| evidence for infectious agents in cardiovascular disease and atherosclerosis. | during the past decade, several novel risk factors for atherosclerosis, including inflammation and infections, have been reported. seroepidemiological studies suggest an association between several microbes and coronary heart disease. microbes or their structural components are found in atherosclerotic plaques, but the only intact microbes commonly present are herpes viruses and chlamydia pneumoniae. these agents are able to initiate and accelerate atherosclerosis in animal models. if they cause ... | 2002 | 11892489 |
| assessment of polymerase chain reaction and serology for detection of chlamydia pneumoniae in patients with acute respiratory tract infection. | to study chlamydia pneumoniae (c. pneumoniae) infection in 110 patients with respiratory tract infection admitted to our hospital from january to december 1995 in nanjing. | 2002 | 11940327 |
| hyperhomocyst(e)inemia and chlamydia pneumoniae igg seropositivity in patients with coronary artery disease. | elevated levels of homocyst(e)ine and infection by chlamydia pneumoniae have been hypothesized individually to play a role in coronary artery disease (cad), but the mechanisms are unclear. data on a possible association are not available. we investigated the correlation between igg antibody titers against c. pneumoniae and fasting plasma homocyst(e)ine in 234 consecutive male patients with cad. chlamydial antibodies to a recombinant genus-specific lipopolysaccharide (lps) were measured with elis ... | 2002 | 11947909 |
| chlamydia pneumoniae infection induces differentiation of monocytes into macrophages. | migration and differentiation of monocytes to the intima of blood vessels may be a crucial first step in the development of atherosclerosis associated with chlamydia (chlamydophila) pneumoniae. however, the involvement of c. pneumoniae infection in such steps is not clear. in the present study, therefore, the differentiation-inducing activity of c. pneumoniae to monocytes was examined. human thp-1 monocytic cell line cells were infected with c. pneumoniae, and the differentiation of monocytes to ... | 2002 | 11953375 |
| temporal arteritis and chlamydia pneumoniae: failure to detect the organism by polymerase chain reaction in ninety cases and ninety controls. | to examine the reported correlation between the presence of chlamydia pneumoniae in temporal artery biopsy specimens and the diagnosis of temporal arteritis (ta). | 2002 | 11953984 |
| in-vitro activity of moxifloxacin and other fluoroquinolones against chlamydia species. | the in-vitro activity of moxifloxacin, a new fluoroquinolone, against chlamydia species was investigated. the minimal inhibitory concentration of moxifloxacin for 10 standard strains of different chlamydia species and 15 wild-type strains of chlamydia pneumoniae isolated in japan, which were morphologically different from clinical isolates from the united states, ranged from 0.031 to 0.125 microg/ml. the activity of moxifloxacin was almost the same as those of sparfloxacin, and it was 16, 8, 2, ... | 2002 | 11957133 |
| [anti-c. pneumoniae igg, iga and igm antibodies in patients undergoing coronary artery bypass grafting]. | the aim of the study was to analyse the prevalence of anti-c. pneumoniae specific igg, iga and igm antibodies in patients undergoing coronary artery bypass engraftment. sera of forty-six patients aged from 40 to 74 years (mean 57.3) were examined just before the time of operation. serum samples taken from 21 young healthy blood donors aged from 19 to 28 years (mean 22.4) and 23 sera taken from older blood donors aged 44-60 years (mean 54.7), were used as controls. specific igg, iga and igm serum ... | 2002 | 11957794 |
| a role for neutrophils in asthma? | 2002 | 11959064 | |
| no evidence of parvovirus b19, chlamydia pneumoniae or human herpes virus infection in temporal artery biopsies in patients with giant cell arteritis. | recent studies have suggested that infective agents may be involved in the pathogenesis of giant cell arteritis (gca), in particular chlamydia pneumoniae and parvovirus b19. we investigated temporal arteries from patients with gca for these infections as well as human herpes viruses using the polymerase chain reaction (pcr). | 2002 | 11961176 |
| comparison of eleven commercial tests for chlamydia pneumoniae-specific immunoglobulin g in asymptomatic healthy individuals. | the seroprevalence of anti-chlamydia pneumoniae-specific immunoglobulin g (igg) antibodies is high in the adult population. experience is required to perform a microimmunofluorescence test (mif), the current "gold standard" for serological diagnosis, and the assay still lacks standardization. partially automated enzyme-linked immunosorbent assays (elisas) and enzyme immunoassays (eias), which are more standardized and for which the reading of results is less subjective, have been developed. the ... | 2002 | 11980928 |
| modulating airway defenses against microbes. | prevention and treatment of respiratory infections remain an important health care challenge as the us population ages, contains more susceptible or high-risk people, and encounters new pathogens or antibiotic resistant bacteria. reasonably protective vaccines against very common microbes are available for childhood and adult immunization, but, generally, these are underutilized. a broader definition of higher risk individuals is evolving, which will include more for immunization. different appr ... | 2002 | 11981302 |
| antibody reactivity of a standardized human serum protein solution against a spectrum of microbial pathogens and toxins: comparison with fresh frozen plasma. | in this study, we compared a standardized solution of human serum protein (hsp) and fresh frozen plasma (ffp) with regard to the antibody specificity against a number of microbial pathogens and some important pathogenicity factors of bacterial pathogens. due to the clinical use of hsp and ffp for therapeutical plasma exchange, we have chosen a spectrum of microbial pathogens for serological analysis that is critical in clinical settings. with the enzyme-linked immunosorbent assay technique, we c ... | 2002 | 11982956 |
| association between seropositivity to chlamydia pneumoniae and acute ischaemic stroke. | recent studies suggest an association between chlamydia pneumoniae infection with atherosclerosis, including cerebrovascular disease. we investigated the prevalence of chlamydial seropositivity in patients with acute ischaemic stroke syndrome compared with age- and sex-matched control subjects. specific antibodies (iga) to c. pneumoniae were measured by microimmunofluorescence in both the clinical group (n=91) and the control group (n=112). forty patients (43.9%) and 34 controls (30.3%) had posi ... | 2002 | 11985640 |
| pcr in diagnosis of infection: detection of bacteria in cerebrospinal fluids. | 2002 | 11986253 | |
| inclusion fluorescent-antibody test as a screening assay for detection of antibodies to chlamydia pneumoniae. | a study was conducted to determine the ability of the inclusion immunofluorescence assay (inclusion ifa) to act as a screening test to detect samples with antibodies to chlamydia pneumoniae; microimmunofluorescence (mif) was used as the "gold standard." in addition, the inclusion ifa was compared using hep-2 cells infected with either c. pneumoniae cm-1 or chlamydia trachomatis serovar e. a total of 331 serum samples representing a range of mif titers were evaluated. the sensitivities of the inc ... | 2002 | 11986260 |