Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| epstein barr virus nuclear antigen positive lymphoma after cyclosporin a treatment in patient with renal allograft. | 1980 | 6104142 | |
| cyclosporin a and epstein-barr virus. | 1980 | 6105533 | |
| binding of sv40 tumour antigen and epstein-barr-virus nuclear antigen to isolated acid-fixed nuclei. | sv40 tumour antigen (ta) bound to methanol-acetic-acid-fixed interphase nuclei and metaphase chromosomes. this reaction was visualized by the anti-complement immunofluorescence test. the reaction was negative when the nuclei had been treated with deoxyribonuclease prior to the addition of antigen, or when ta-antibody negative serum had been used. in parallel tests ta and epstein-barr virus nuclear antigen were examined. both the binding patterns and the optimum conditions for the reaction were s ... | 1980 | 6107019 |
| infectious mononucleosis and acute monocytic leukemia. | 1980 | 6107449 | |
| when does lymphoproliferation become malignant lymphoma? | 1980 | 6107794 | |
| cyclosporin a, transplantation, and lymphoma. | 1980 | 6108465 | |
| tumour-promoting phorbol esters inhibit dna synthesis and enhance virus-induced interferon production in a human lymphoma cell line. | 12-o-tetradecanoyl-phorbol-13-acetate (tpa), a potent tumour promoter, was tested for its effects on the proliferation of the human burkitt lymphoma cell line, namalwa, and the synthesis of interferon by these cells. at nanomolar concentrations, tpa blocked thymidine incorporation into cellular dna by more than 90% within 24 h. tpa-treated cells produced about 20-fold more interferon in response to sendai virus than did untreated controls and simultaneous treatment with tpa and sodium n-butyrate ... | 1980 | 6161998 |
| observations on the eb virus envelope and virus-determined membrane antigen (ma) polypeptides. | experiments have been carried out to identify the polypeptide components of the epstein-barr (eb) virus-determined membrane antigen (ma) complex. cells were radioiodinated using lactoperoxidase and the 125i-labelled surface antigens, released by triton x100, were analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) after complexing either with human sera having anti-ma activity or with a rabbit antiserum to eb virus. using cells carrying eb virus isolated from four d ... | 1980 | 6162806 |
| herpes: scourge of the seventies. | 1980 | 6243084 | |
| lymphoma after thymus transplantation. | 1980 | 6243173 | |
| effect of the diterpene ester tpa on epstein-barr virus antigen- and dna synthesis in producer and nonproducer cell lines. | 1980 | 6243196 | |
| the suppression of epstein-barr virus infection in vitro occurs after infection but before transformation of the cell. | it has been demonstrated that t cells from humans can suppress the transformation of ebv-infected b cells in vitro. in this paper, studies are presented on the mechanism of the suppression. the t cells do not act against the virus itself nor the infection process. they appear to suppress the outgrowth of b cells after they are infected but before they are transformed. the t cells are much less effective in suppressing the outgrowth of the b cells once the latter have transformed (24th post-infec ... | 1980 | 6243331 |
| attempts to induce interferon production by idurd induction and ebv superinfection in human lymphoma lines and their hybrids. | inducers of the epstein-barr virus (ebv) cycle, 5-iodo-2-deoxyuridine (idurd), phorbol myristate acetate (tpa) and sodium butyrate were tested for their ability to induce ebv-determined antigens, early antigen (ea) and virus capsid antigen (vca), and to stimulate interferon (if) production in a variety of ebv-carrying lymphoid cell lines. idurd and tpa induced if production to various extents in the different lines, whereas sodium butyrate did not. there was no relationship between induction of ... | 1980 | 6243338 |
| transformation of human leukocytes with epstein-barr virus after cellular exposure to chemical or physical mutagens. | assays that quantitate leukocyte transformation were used to determine the effect of two chemical and two physical mutagens on epstein-barr virus (ebv)-induced transformation of human umbilical cord leukocytes (hucl). after treatment of hucl with methyl methanesulfonate (mms). uv light, or x-rays, lymphocyte transformation by ebv displayed a typical "survival" curve usually associated with agent toxicity in dividing cell populations. viral transformation showed increasing resistance to each of t ... | 1980 | 6243375 |
| studies on the activity of dnase associated with the replication of the epstein-barr virus. | 1980 | 6243430 | |
| studies of serum immunoglobulin binding to synovial fibroblast cell cultures from patients with rheumatoid arthritis. | using a sensitive 125i-protein a (pra) binding assay to detect cell surface igg, we have studied seven different synovial fibroblast cell cultures from patients with rheumatoid arthritis (ra). when these cultures were incubated in the presence of serum from 18 autologous and allogeneic ra patients (all seropositive), we were unable to detect significant igg binding. since igm rheumatoid factor (rf) can block pra binding, sera were absorbed with aggregated igg to remove rf without affecting the r ... | 1980 | 6243465 |
| further studies on inhibition of epstein-barr virus release by bovine serum: partial purification and characterization of the inhibitor. | the antivirus release factor (avrf) was extracted from adult bovine serum and was partially purified in three steps by 1) ammonium sulfate precipitation, 2) sephadex g-200 chromatography, and 3) deae-sephadex chromatography, procedures that together increased specific activity 160 times. in molecular sieve chromatography, avrf was found in fractions close to igm. the avrf activity was sensitive to kio4 (0.04 m) but not to trypsin (0.1%), uv irradiation, ethyl ether, and heating at 56 degrees c f ... | 1980 | 6243717 |
| characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for epstein-barr virus nuclear antigen. i. physical, cytogenetic, and growth characteristics. | sixteen lymphoid cell lines were derived from patients with undifferentiated lymphoma of burkitt's or non-burkitt's type. they were obtained directly from tumor biopsies, from serous effusions, or from bone marrow. in 10 of the cell lines, the epstein-barr virus (ebv) nuclear antigen (ebna) was undetectable; the remaining 6 lines were ebna-positive (eb-pos). of the 16 lines, 15 were aneuploid, with detectable chromosome "14q+ markers (11 had +8;14 translocations). these 15 lines, which included ... | 1980 | 6243721 |
| characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for epstein-barr virus nuclear antigen. ii. surface markers. | fifteen of 16 lymphoma-derived cell lines and the faji and p3hr1 cell lines were characterized with regard to certain surface markers, particularly immunoglobulins, complement receptors, epstein-barr virus (ebv) receptors, and fc receptors. ten lines positive for ebv nuclear antigen (eb-pos) were stained weakly or not at all by antihuman immunoglobulin fluorescein isothiocyanate conjugates, whereas ebv nuclear antigen negative (eb-neg) cell lines stained brightly. eb-pos lines frequently manifes ... | 1980 | 6243722 |
| [carcinomas of the nasopharynx. relationship between histological type and anti-epstein-barr virus serology (author's transl)]. | this study was aimed at the comparison of values of anti-epstein-barr virus serology in different groups of patients suffering from carcinoma of the nasopharynx (npc), classified according to histological type defined by the new classification of the who. a group of patients with other tumours of the upper respiratory and digestive tract was used as a control. antibody levels were high in patients with undifferentiated carcinomas whilst they were low in the controls. in patients with differentia ... | 1980 | 6243770 |
| effect of inhibition of dna synthesis on epstein--barr virus induction by tumor promoters. | 1980 | 6243817 | |
| characterization of an ebv-like virus from african green monkey lymphoblasts. | 1980 | 6243826 | |
| epstein-barr virus antibodies in multiple sclerosis. | serum antibody titers to epstein-barr virus (ebv), an agent that persists in a latent form after the initial infection, were determined in 157 patients with multiple sclerosis and in 81 control subjects. two patients (1.3%) and five control subjects (6.2%) lacked antibodies to ebv. in the subjects with antibodies, the prevalence of high titers (greater than or equal to 1:160) was significantly greater in patients, 69 (44.5%), than in control subjects, 22 (28.9%). the geometric mean titer of anti ... | 1980 | 6243930 |
| mitogen requirements for the in vitro propagation of cutaneous t-cell lymphomas. | 1980 | 6244013 | |
| a human liposarcoma cell line producing hyaluronic acid. | a human liposarcoma cell line colo 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. colo 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. a chromosome mode of 53 predominates and unique giemsa-banded marker chromosomes are identified. an autochthonous lymphoid cell line, colo 143v, was established after the addition of exogenous epstein-barr virus. cytogenetic an ... | 1980 | 6244080 |
| prognostic factors in burkitt's lymphoma: importance of total tumor burden. | in 42 patients with african burkitt's lymphoma, we have studied biochemical and clinical correlations with prognosis. clinical stage and anti-ea titer were the best predictive factors, but lactic dehydrogenase (ldh) and uric acid (ua) concentrations also correlated with stage and prognosis, whereas lactic acid (la), which was significantly elevated in stage d, did not significantly correlated with prognosis or with ldh and ua levels. all of these factors with the possible exception of la reflect ... | 1980 | 6244085 |
| [manifestations of periodicity in a long term study of children's collectives]. | 1980 | 6244114 | |
| nc37-r1 epstein-barr virus (ebv): a possible recombinant between intracellular nc37 viral dna and superinfecting p3hr-1 ebv. | the nc37-r1 cell line, established after transformation of human cord blood lymphocytes with epstein-barr virus (ebv) recovered from p3hr-1 superinfected nc37 cells, spontaneously produces viral particles with transforming but without early antigen-inducing properties. progeny virus of nc37-r1 has retained its biological characteristics of spontaneous virus release and transformation up to four cycles of transformation at present. analysis of purified nc37-r1 virion dna, after cleavage with rest ... | 1980 | 6244234 |
| in vitro induction of cytotoxic t lymphocytes specific for epstein-barr virus-transformed cells: kinetics of autologous restimulation. | 1980 | 6244347 | |
| increased sensitivity of human lymphoid lines to natural killer cells after induction of the epstein-barr viral cycle by superinfection or sodium butyrate. | superinfection of latently epstein-barr virus (ebv)-carrying raji cells with the p3hr-1 substrain ebv, known to induce the entry of a substantial fraction of cells into an abortively lytic cycle, increased the susceptibility of the cells to natural killer (nk) effect of human blood lymphocytes. reciprocal cold-target competition tests with known nk-cell sensitive and -resistant lymphoid cell ines showed that the increased susceptibility is a result of the appearance of an nk-sensitive target, ra ... | 1980 | 6244358 |
| hla-restricted t-cell recognition of epstein-barr virus-infected b cells. | in mice the cytotoxic t-cell response to several types of virus is influenced by genes within the major histocompatibility complex; in particular, genetic control is exercised at the effector cell level through a requirement that virus-specific cytotoxic t cells recognise viral antigens in association with h-2k and h=2d region gene products on the surface of infected cells. in man the restriction which the analogous hla-a, -b and -c-region gene products might place on virus-specific t-cell funct ... | 1980 | 6244495 |
| herpes simplex virus depresses antibody production by affecting t-cell function. | many viruses enter lympho-reticular cells during pathogenesis and thereby induce immunosuppression, which is of practical importance in that it may be related to overall virulence. immunosuppression may result from a selective infection, as viruses often show an affinity for different lymphocyte subpopulations: epstein-barr virus, for example, infects only a small percentage of b cells. we reported previously that herpes simplex virus (hsv) type 1 suppressed the induction of an antibody response ... | 1980 | 6244499 |
| expression of epstein-barr virus genes in different cell types after microinjection of viral dna. | gene expression of epstein-barr virus (ebv) was studied after microinjection of viral dna into different types of cells. raji tk- cells, known to express viral gene functions after superinfection with the ebv-p3hr-1 virus strain, were attached to plastic dishes by using anti-lymphocyte igg, phytohemagglutinin, or concanavalin a as a ligand. it was difficult to inject dna into the small and fragile raji cells. after formation of polykaryons by cell fusion, microinjection became more efficient. at ... | 1980 | 6244558 |
| [infectious mononucleosis. cytology and immunological significance]. | 1980 | 6244613 | |
| [epstein-barr virus]. | 1980 | 6244614 | |
| [heterophil antibody negative infectious mononucleosis due to epstein-barr virus. a clinical, hematological and serological study of 14 cases (author's transl)]. | fourteen patients admitted to the hospital for heterophil antibody negative infectious mononucleosis (im) were studied; the causative agent was epstein-barr virus, as confirmed by the presence of anti-vca antibodies (igg and igm) and the absence of anti-ebna antibodies. the patients were from 2 to 69 years old, 7 being less than 10 years old while 4 were more than 45 years old. in all cases, asthenia and adenopathy were found and a deterioration in liver functions was present whenever it was loo ... | 1980 | 6244662 |
| markers of human lymphocyte subpopulations in primary immunodeficiency and lymphoproliferative disorders. | 1980 | 6244677 | |
| induction and biological characterization of the epstein-barr virus (ebv) carried by the jijoye lymphoma line. | 1980 | 6244705 | |
| sinus histiocytosis with massive lymphadenopathy in a japanese adult with unusually elevated ebv antibody titers. | a 35-year-old japanese male was presented with massive lymphadenopathy in bilateral preauricular and submandibular regions for five years' duration without any complaints despite of no specific treatments. laboratory examinations revealed neurtrophilia, elevated bsr, hypergammaglobulinemia with elevated igg and igm, positive crp and ra, low percentage of t-cells in peripheral blood, impaired pha blast transformation, and elevated ebv titers against viral capsid, early and nuclear antigens. biops ... | 1980 | 6244711 |
| persistent transfusion-associated infectious mononucleosis with transient acquired immunodeficiency. | trauma and blood transfusion led to profound, persistent infectious mononucleosis in a 21 year old man. splenectomy and trauma had apparently produced transient immune deficiency which was complicated by osteomyelitis of a fractured tibia. the transfused blood probably contained epstein-barr virus (ebv). infectious mononucleosis had ensued 25 days after a blood transfusion was given, antibodies to ebv appeared in his serum, and the infectious mononucleosis persisted for nearly two years. his imm ... | 1980 | 6244733 |
| epstein-barr virus-positive burkitt's lymphoma in a german woman during pregnancy. | a fatal case of a burkitt's lymphoma which occurred in a 34-year-old german woman during pregnancy is described. nearly all organs showed either diffuse or nodular infiltration by tumor cells. placenta and fetus were free of detectable tumor tissue. the patient had extremely high antibody titers (1 : 2056), both against epstein-barr virus capsid antigen (vca) and the early antigen complex (ea). within the tumor cells the epstein-barr virus-specific nuclear antigen ebna and viral dna was detected ... | 1980 | 6244869 |
| c3-activating proteases on human lymphoblastoid cells superinfected with epstein-barr virus. | 1980 | 6244899 | |
| antibody to the rheumatoid arthritis nuclear antigen. its relationship to in vivo epstein-barr virus infection. | most patients with seropositive rheumatoid arthritis, and a variable but lesser percentage of normal subjects, have precipitating antibodies to a nuclear antigen, rheumatoid arthritis nuclear antigen, present in epstein-barr virus-infected human b lymphoblastoid cells. we have used a sensitive indirect immunofluorescence assay for antibody to rheumatoid arthritis nuclear antigen in a study of patients with infectious mononucleosis and healthy control subjects. of 110 sera from normal, college-ag ... | 1980 | 6245108 |
| production of diphtheria antitoxin antibody in epstein-barr virus-induced lymphoblastoid cell lines. | 1980 | 6245131 | |
| deficiency of epstein-barr virus (ebv) receptors on b lymphocytes from certain patients with common varied agammaglobulinemia. | 1980 | 6245136 | |
| herpesvirus-lymphoid cell interactions: comparative studies on the biology of herpes simplex virus-induced fc receptors in b, t, and "null" lymphoid cell lines. | we have investigated the induction of fc receptor (fcr) in different types of lymphoid cell lines (lcl) infected with herpes simplex virus (hsv). subpopulations of certain of these lcl normally express fcr unrelated to herpetic infection. differentiation of virus-induced fcr from that related to normal cell function was therefore possible. fcr detection was carried out by means of a rosette assay using ox erythrocytes coated with 7s immunoglobulin g (ea rosettes). both hsv types 1 and 2 were fou ... | 1980 | 6245224 |
| organization of repeated regions within the epstein-barr virus dna molecule. | virions of human epstein-barr virus released from the b95-8 line of marmoset lymphoblasts have linear double-stranded dna molecules of 115 x 10(6) molecular weight (180 +/- 10 kilobase pairs). approximately 20% of this dna yields multiple fragments of 3,200 base pairs when cleaved with any one of the bglii, bamhi, pvuii, saci, sstii, or xhoi restriction enzymes. the results of cleavage site mapping with these and other enzymes, together with blot hybridization experiments using the 3.2-kilobase ... | 1980 | 6245247 |
| fatal monomucleosis? don't rule it out. | 1980 | 6245284 | |
| registry of fatal infectious mononucleosis and epstein-barr virus infections. | 1980 | 6245285 | |
| hybridization of a myeloid leukemia-derived human cell line (k562) with a human burkitt's lymphoma line (p3hr-1). | the myeloid leukemia-derived epstein-barr virus (ebv)-negative human lymphoid cell line k562 was successfully hybridized with the ebv-carrying burkitt's lymphoma line p3hr-1. authenticity of the hybrid putko-1 was established by chromosome and isoenzyme studies. a virtually complete hybrid putko-1 carried the ebv genome derived from the lymphoma parent. it averaged 26 ebv dna copies per cell and was 100% positive for epstein-barr virus-associated nuclear antigen (ebna). in most respects, the hyb ... | 1980 | 6245297 |
| attempt to infect nonmalignant nasopharyngeal epithelial cells from humans and squirrel monkeys with epstein-barr virus. | with the use of epstein-barr virus (ebv), attempts were made to infect epithelial nasopharyngeal explant cell cultures prepared from nonmalignant human and squirrel monkey tissue. explants were exposed to ebv from both hr-1 and b95-8 cells and examined for ebv-specific antigens by immunofluorescence and electron microscopy. among the human specimens, no epithelial nasopharyngeal were found that could be infected with ebv. however, similar explants derived from squirrel monkey tissue were infecte ... | 1980 | 6245300 |
| diffuse polyclonal b-cell lymphoma during primary infection with epstein-barr virus. | 1980 | 6245364 | |
| epstein-barr virus--oncogen or mitogen? | 1980 | 6245366 | |
| active secretion of cytoskeletal and mechanochemical proteins in ebv-genome-positive human lymphocytes. | 1980 | 6245489 | |
| phosphonoformate inhibits synthesis of epstein-barr virus (ebv) capsid antigen and transformation of human cord blood lymphocytes by ebv. | 1980 | 6245504 | |
| epstein-barr virus-induced proteins. iii. analysis of polypeptides from p3hr-1-ebv-superinfected nc37 cells by immunoprecipitation. | 1980 | 6245505 | |
| radioimmune precipitation study comparing the epstein-barr virus membrane antigens expressed on p3hr-1 virus-superinfected raji cells to those expressed on cells in a b-95 virus-transformed producer culture activated with tumor-promoting agent (tpa). | 1980 | 6245514 | |
| glycoproteins and sialyl transferase of human b lymphoblastoid cell lines. | we used two radiolabeling methods to study glycoproteins on the surface of lymphoblastoid cells. one of the methods affects tritiation of residues which are oxidized with galactose oxidase and the other causes tritiation of neuraminic acid residues. this approach was shown to allow a better resolution of cell surface glycoproteins than if either method were used alone. glycoproteins of b1--19 cells which harbor the epstein-barr virus genomes were compared with those of its parental cell line, bj ... | 1980 | 6245632 |
| differential inhibition of epstein-barr virus induction by the amino acid analogue, l-canavanine. | the effect of an amino acid analogue, l-canavanine, on the synthesis of epstein-barr virus (ebv) antigens was investigated in lymphoblastoid cells. the analysis revealed that after infection of bjab and nc-37 cells with p3hr-i ebv synthesis of early antigen (ea) was not affected by canavanine in concentrations up to 8.4 mm. the synthesis of ebv-determined nuclear antigen (ebna) and of viral capsid antigen (vca) was significantly inhibited at concentrations higher than 2.8 mm. spontaneous inducti ... | 1980 | 6246007 |
| application of an immunoenzymatic method and an immunoautoradiographic method for a mass survey of nasopharyngeal carcinoma. | the frequency of iga antibody to virus capsid antigen (vca) of eb virus was tested by an immunoenzymatic method among adults in a mass serological screening of the general population of 6 communes in south china, as a guide toward early detection of nasopharyngeal carcinoma. sera from 56 patients already recognized as having nasopharyngeal carcinoma (npc) also were tested. the screening was conducted with sera from 56,584 persons age 30 years and older in zangwu county in the guangsi zhuang auto ... | 1980 | 6246033 |
| effect of mitomycin c and hydroxyurea on the expression of the epstein-barr virus cycle following p3hr-1 superinfection. | epstein-barr virus (ebv) dna synthesis following ebv p3hr-1 superinfection of the burkitt lymphoma cell line, daudi, is refractory to mitomycin c and hydroxyurea at concentrations which inhibit cell dna synthesis to greater than 98% of control values. further, neither mitomycin c nor hydroxyurea inhibit virus antigen synthesis following p3hr-1 superinfection. | 1980 | 6246034 |
| induction of epstein-barr virus-associated dna polymerase by 12-o-tetradecanoylphorbol-13-acetate. purification and characterization. | the diterpene ester promoter of mouse skin tumors, 12-o-tetradecanoylphorbol-13-acetate (tpa), efficiently induces epstein-barr virus (ebv)-associated dna polymerase (dna nucleotidyltransferase) activity in the ebv-producing lymphoblastoid cell line, p3hr-1. with the use of intervent dilution chromatography followed by sequential deae-cellulose and phosphocellulose column chromatography, the virus-associated enzyme has been isolated and purified 300-fold. the partially purified ebv dna polymeras ... | 1980 | 6246099 |
| purification and biochemical characterization of an inhibitor of dna synthesis produced by an epstein-barr virus-transformed b cell line. | an inhibitory factor, which has been shown to suppress the uptake of 125i-iododeoxyuridine by both lymphoid and nonlymphoid cells, was isolated from the supernatant of an epstein-barr virus- (ebv) transformed b cell line (1605l) established from a cotton-topped marmoset. purification of the inhibitor, which was produced in serum-free medium by crowded cultures of the 1605l cells, was achieved by deae-cellulose chromatography followed by preparative polyacrylamide gel electrophoresis. the apparen ... | 1980 | 6246172 |
| polypeptide synthesis and phosphorylation in epstein-barr virus-infected cells. | epstein-barr virus superinfection of the human lymphoblastoid cell line raji, a burkitt lymphoma-derived line that contains epstein-barr virus genomes in an episomal form, results in the sequential synthesis of 29 detectable proteins, which range in molecular weight from approximately 155,000 to 21,000, and in the shutoff of the bulk of host protein synthesis within 6 to 9 h after infection. there are three classes of virus-induced proteins; these are an early class, consisting of eight proteins ... | 1980 | 6246275 |
| effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on epstein-barr virus dna replication. | the effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on epstein-barr virus (ebv) dna replication in the lymphoblastoid cell lines p3hr-1 and raji is reported. acyclovir at a concentration of 100 microm completely inhibited ebv dna synthesis in superinfected raji cells, but did not inhibit dna synthesis in mock-infected cells. the number of ebv genome equivalents per cell in the virus-producing cell line p3hr-1 was significantly reduced by acyclovir, whereas the number of latent ebv genomes ... | 1980 | 6246281 |
| human nasopharyngeal carcinomas positive for epstein-barr virus dna in north america. | nasopharyngeal carcinomas (npc) from 2 black patients and 1 caucasian patient were positive for epstein-barr virus (ebv) dna. of the tumors, 2 were lymphoepitheliomas (undifferentiated npc) and 1 was a moderately differentiated npc. all 3 patients had high igg titers against ebv early antigen and high igg and iga titers against virus capsid antigen (vca). in one patient, the levels of anti-vca iga were different than those of anti-vca igg over the course of the disease. our data support the asso ... | 1980 | 6246300 |
| studies of platelet monoamine oxidase activity in epstein-barr and dengue virus infections. | as part of a prospective, psychosocial, and biochemical study of infectious mononucleosis, platelet monoamine oxidase (mao) activity has been evaluated as a host factor. it was found that platelet mao activity may be a possible predisposing host factor but not a precipitating factor. the results on infectious mononucleosis, a viral disease which involves the host's cell-mediated immune system, are compared with an evaluation of platelet mao activity in dengue, a viral disorder involving the host ... | 1980 | 6246572 |
| latex test for serodiagnosis of infectious mononucleosis. | a glycoprotein was isolated from bovine erythrocytes which has 20% carbohydrate and migrates on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as a single band. this glycoprotein carries the reactivity of bovine erythrocytes with paul-bunnell heterophile antibody of infectious mononucleosis. this bovine glycoprotein was coupled to carboxyl-modified latex particles with water-soluble carbodiimide. the resulting reagent was then used to develop a new test for the detection of infectious ... | 1980 | 6247367 |
| ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital x-linked agammaglobulinemia. | lymphoblastoid cell lines were established from female relatives of patients with congenital x-linked-agammaglobulinemia by epstein-barr virus transformation of their peripheral b lymphocytes. cell lines derived from presumed carriers were characterized by low ecto-5'-nucleotidase activity and a reduced percentage of surface immunoglobulin-bearing cells. measurement of ecto-5'-nucleotidase activity in newly established lymphoblastoid cell lines may provide a means for the identification of heter ... | 1980 | 6247393 |
| ebv-transformation of surface iga-positive human lymphocytes. | surface iga-positive human lymphocytes were selected, separated, and immortalized with epstein-barr virus (ebv). selection was carried out by rosetting the cells with ox erythrocytes, coated with rabbit anti-human iga immunoglobulin, followed by separation on ficoll-isopaque. stable monoclonal lines were established by cloning in agarose. this shows that ebv-transformation is not restricted to the igm-positive b cell category but can be extended to minority classes of b lymphocytes. the method p ... | 1980 | 6247394 |
| igm antibodies to epstein-barr virus-associated membrane antigen in sera of infectious mononucleosis patients. | by the indirect immunofluorescence technique, igm antibodies to the cell surface of an epstein-barr virus (ebv) producer cell line, p3hr-1, were detected in sera from infectious mononucleosis (im) patients but not in sera from patients with burkitt lymphoma or nasopharyngeal carcinoma nor in sera from healthy adult donors having antibodies to ebv-specific viral capsid antigen (vca). titers of the igm antibodies were higher in the earlier stages of im, a pattern similar to that for igm antibodies ... | 1980 | 6247623 |
| fatal infectious mononucleosis. | 1980 | 6247653 | |
| virology and cancer. | 1980 | 6247712 | |
| [epstein-barr-virus induced glomerulonephritis]. | 1980 | 6247779 | |
| [epstein-barr virus infection in early childhood]. | 1980 | 6247799 | |
| detection of virus-specific antigens in eb-(p3hr1) virus-superinfected raji cells by immunoprecipitation. | 1980 | 6247820 | |
| nummular keratitis associated with infectious mononucleosis. | a 16-year-old boy had a severe case of infectious mononucleosis with a rising titer to the epstein-barr virus. the patient had developed a nummular keratitis apparently associated with this illness. because infectious mononucleosis or infection by the epstein-barr virus is often subclinical, and many cases of nummular keratitis have been classified as idiopathic in the past, a possible association between the two in such cases should be considered. | 1980 | 6247917 |
| mitogenic effect of 12-0 tetradecanoyl phorbol 13-acetate on non-human primate mononuclear cells and in vitro interaction with epstein-barr virus transformation. | 12-0 tetradecanoyl phorbol 13-acetate (tpa), known to promote tumors in mice and also to enhance viral transformation as well as induction of viral antigens, was demonstrated to be mitogenic to peripheral blood mononuclear cells from rhesus monkeys and three species of marmosets. even though mitogenic responses varied between species and within species, the mitogenic dose response due to tpa was comparable to the response of phytohemagglutinin (pha-p). a significant synergistic effect of pha-p a ... | 1980 | 6247996 |
| deficiency of carnitine palmitoyltransferase in transformed lymphoblasts from a patient having a deficiency of carnitine palmitoyltransferase in skeletal muscle. | 1980 | 6248058 | |
| altered regulation of epstein-barr virus induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells. | 1980 | 6248075 | |
| tests for infectious mononucleosis. | 1980 | 6248155 | |
| diagnosis of infectious mononucleosis. | 1980 | 6248161 | |
| lymphoid cell line identification and the detection of cross contamination. | four lymphoid cell lines, presumably recent derivatives from non-neoplastic human tonsils, were identified in actuality as established burkitt lymphoma and lymphoblastoid cell lines (lcl) when tested by chromosome banding and typing for hla antigens. additionally, the morphology, growth characteristics, tumorigenicity, expression of epstein-barr virus antigens and surface membrane immunoglobulins (smig) of the four lymphoid cell lines confirmed the correct identifications. in determining the pos ... | 1980 | 6248453 |
| enzyme-linked immunosorbent assay for detection of virus-specific igm antibodies to varicella-zoster virus. | a sensitive enzyme-linked immunosorbent assay (elisa) is described for detection of varicella-zoster virus (vzv) igm antibodies. the antigen consisted of a sonically disrupted extract of vzv-infected human embryo cells. the tested sera were absorbed with staphylococcus aureus (strain cowan i) before analysis. rabbit anti-human igm peroxidase conjugate was used to detect human igm bound to viral antigen. the results were compared with those obtained by the indirect fluorescent antibody to membran ... | 1980 | 6248482 |
| analysis of the transformation of human lymphocytes by epstein-barr virus. ii. abortive response of leukemic cells to the transforming virus. | leukemic lymphocytes with b-cell markers were obtained from the peripheral blood of 4 patients with chronic lymphocytic leukemia (cll) or acute lymphocytic leukemia (all); a significant number of t cells was not involved. the lymphocytes were inoculated with the transforming b95-8 epstein-barr virus (ebv). synthesis of ebv-determined nuclear antigen (ebna) occurred in three cll preparations: 15.1--25.4% of cells expressed maximum ebna 24--48 h after viral exposure. a characteristic immunofluores ... | 1980 | 6248483 |
| dissociation of opsonized particle phagocytosis and respiratory burst activity in an epstein-barr virus-infected myeloid cell line. | a continuous tissue culture cell line (karpas line 120), derived from a patient with acute myeloblastic leukemia, not only demonstrates myeloblastic morphology and in vitro expression of several myeloid-specific biochemical markers but also contains epstein-barr virus (ebv) nuclear antigen. the present studies demonstrate ebv-genome-specific dna within the total cellular dna by molecular hybridization, thus establishing the presence of stable viral genome integration. the cells demonstrate compl ... | 1980 | 6248564 |
| antibody responses to epstein-barr virus in families with the x-linked lymphoproliferative syndrome. | 1980 | 6248598 | |
| lymphocyte reactivity in infectious mononucleosis. | reactivity of lymphocytes to a purified preparation of epstein-barr virus (ebv) was studied in 17 healthy individuals and 15 patients with primary evb infection and clinical signs of infectious mononucleosis. lymphocyte reactivity to ebv was negative in individuals who were seronegative for antibody to ebv and in seven of 15 patients examined less than or equal to 21 days after onset of clinical signs of illness. positive lymphocyte reactivity was observed in all patients by day 36; once it was ... | 1980 | 6248602 |
| immunoglobulin a antibody to epstein-barr viral antigens and prognosis in nasopharyngeal carcinoma. | iga immunoglobulin fractions containing antibodies to epstein-barr virus (ebv)-induced membrane antigens were isolated from the sera of two patients with nasopharyngeal carcinoma (npc), from one non-npc patient, and from three persons with sera negative for iga antibodies. iga antibodies were not cytotoxic against cells expressing ebv-induced membrane antigens in the antibody-dependent cellular cytotoxicity (adcc) assay. however, iga antibodies blocked igg-mediated adcc, which indicated that the ... | 1980 | 6248828 |
| [immunovirological studies in children with hodgkin's disease]. | 1980 | 6248835 | |
| monoclonal antibody against a 250,000-dalton glycoprotein of epstein-barr virus identifies a membrane antigen and a neutralizing antigen. | an antibody-secreting hybrid cell line was produced by fusion of mouse myeloma cells with splenocytes from mice immunized with virions of the b95-8 strain of epstein-barr virus (ebv). the monoclonal igg antibody was shown to have anti-ebv activity by the following criteria: (i) it reacted with the membranes and the cytoplasm of seven different ebv-producing lines, but with no nonproducing line. (ii) the individual cells identified by the murine antibody were shown to be the same cells identified ... | 1980 | 6248876 |
| epstein-barr virus (b95-8) dna vii: molecular cloning and detailed mapping. | two of the sal i fragments and all of the internal bamhi fragments (with the exception of bamhi c, a 0.6 x 10(6) dalton fragment) of epstein-barr virus (ebv) dna have been cloned in pbr322. the termini and other parts of the dna (including the ecori fragment which contains bamhi c) have been cloned as ecori fragments in bacteriophage charon 4a. the cloned dnas have been used to derive a complete map of the bamhi fragments of ebv dna and to align the bamhi, ecori, hindiii, and sali cleavage sites ... | 1980 | 6248879 |
| adaptation of membrane-associated determinants is an outgrowth of their metabolism. | the quantity of receptors expressed by specialized cells for hormones, foreign antigenic substances, and other chemical stimuli diminishes after they associate with ligands, correlating with a specific reduction in the responsiveness of the cell to further stimulation. ligand-induced adaptation of membrane receptors may be akin to antigenic modulation--the reversible disappearance of membrane-associated determinants stimulated by specific antibodies. antigenic modulation has been studied extensi ... | 1980 | 6248890 |
| effects of arabinofuranosylthymine on epstein-barr virus replication. | 1980 | 6249024 | |
| monoarthritis with heterophil-negative infectious mononucleosis. case of an older patient. | a patient aged 57 years with infectious mononucleosis and monoarthritis of the knee joint is described. to our knowledge, this association in elderly patients has not been reported heretofore, nor has the pathogenesis of arthritis in infectious mononucleosis been established. because of the clinical picture and the synovial fluid findings, we suggest that the main mechanism of this arthritis is viral replication in the synovia. | 1980 | 6249228 |
| changed fc and c3 receptor pattern on human ebv-negative lymphoma cells, following in vitro conversion by eb-virus. | 1980 | 6249610 | |
| long-term t-cell-mediated immunity to epstein-barr virus in man. iv. development of t-cell memory in convalescent infectious mononucleosis patients. | under appropriate culture conditions, eb virus infection of lymphocytes from seropositive donors leads to regression of transformation, and this was shown previously to be due to activation in a secondary immune response to t lymphocytes inhibitory for the autologous lymphoblastoid cell line. regression can be quantified by determining the number of cells required for its expression. to investigate the development of memory t cells with eb-virus specificity in the primary infection, a comparison ... | 1980 | 6249763 |
| activated t lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma. | lymphocytes isolated from the tumors and draining lymph nodes of nasopharyngeal carcinoma (npc) patients exhibit the following characteristics of immune activation: (1) stable e rosette formation, (2) natural attachment to various human cells, (3) sensitivity in vitro to the lytic effect of glucocorticoids. although the npc t cells attach in vitro to various cells they kill only ebv-genome-carrying targets. these findings suggest the occurrence of a local cellular immune response in npc, possibl ... | 1980 | 6249765 |
| b cell differentiation and immunoregulatory t cell function in human cord blood lymphocytes. | the functional maturity of t and b lymphocyte populations from human newborns was evaluated using a reverse hemolytic plaque assay to detect immunoglobulin-secreting cells generated in in vitro cultures stimulated with pokeweed mitogen (pwm), a t cell-dependent polyclonal activator, and the epstein-barr virus (ebv), a t cell-independent b cell activator. cord blood lymphocytes failed to produce immunoglobulin in response to pwm, but did respond with immunoglobulin synthesis to stimulation with e ... | 1980 | 6249850 |
| killing of virus-infected cells by cytotoxic lymphocytes. | 1980 | 6249872 |