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impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants.the goal was to examine the impact of birth at night, on the weekend, and during july or august (the first months of the academic year) and the impact of resident duty-hour restrictions on mortality and morbidity rates for very low birth weight infants.201020643715
impact of non-pharmaceutical interventions on uris and influenza in crowded, urban households.we compared the impact of three household interventions-education, education with alcohol-based hand sanitizer, and education with hand sanitizer and face masks-on incidence and secondary transmission of upper respiratory infections (uris) and influenza, knowledge of transmission of uris, and vaccination rates.201020297744
severity of 2009 pandemic influenza a (h1n1) virus infection in pregnant women.to examine 2009 h1n1 influenza illness severity and the effect of antiviral treatment on the severity of illness among pregnant women.201020308830
lessons from queens. 201020187742
2009 pandemic influenza a (h1n1) in pregnant women requiring intensive care - new york city, 2009.pregnant women are at increased risk for severe illness and complications from infection with seasonal influenza and 2009 pandemic influenza a (h1n1). to characterize the severity of 2009 h1n1 infection in pregnant women, the new york city department of health and mental hygiene (dohmh) conducted active and passive surveillance for cases of 2009 h1n1 infection in pregnant women requiring intensive care. this report summarizes the results of that surveillance, which found that, during 2009, 16 pr ...201020339343
salmonella enterica serotype cerro among dairy cattle in new york: an emerging pathogen?the focus of this study was salmonella enterica serotype cerro, a potentially emerging pathogen of cattle. our objectives were to document the within-herd prevalence of salmonella cerro among a sample of new york dairy herds, to describe the antimicrobial resistance patterns and pulsed-field gel electrophoresis types of the isolates, and to elucidate the status of this serotype as a bovine pathogen. data were collected prospectively from dairy herds throughout new york that had at least 150 lact ...201020187753
assessing criminal justice involvement as an indicator of human immunodeficiency virus risk among women in methadone treatment.this study examines the relationship between criminal justice involvement and high-risk sexual partnerships among a random sample of 416 women in methadone treatment in new york city. logistic regression models were used to estimate the associations between recent criminal justice involvement (arrest or incarceration in the past 6 months) and recent high-risk partnerships (multiple sex partners, sex trading, or sex with a risky partner in the past 6 months) when adjusting for sociodemographic fa ...201020356702
unexplained increased incidence of legionnaires disease during the "herald wave" of the h1n1 influenza pandemic. 201020367323
double jeopardy: the impact of neoliberalism on care workers in the united states and south africa.many researchers have explored how neoliberal restructuring of the workplace has reduced the standard of living and increased workplace stress among private sector employees. however, few have focused on how neoliberal restructuring of public policy has had similar effects on the public sector workforce. using original case study research, the authors examine how two iconic pieces of neoliberal policy--the 1996 welfare reform bill in the united states and the gear macroeconomic policy in south a ...201020198806
from bench to clinic: accessing promising investigational medications for patients with hiv infection in an urban family health center.patients who experience failure of treatment for human immunodeficiency virus and who have no other treatment options can sometimes obtain promising investigational medications through expanded access programs. however, psychosocial and socioeconomic factors, common among underserved populations, create barriers to enrollment at referral centers. to increase access for unstable patients, an urban family health center developed the capacity to provide investigational medications directly to patie ...201020823350
deaths from seasonal influenza among pregnant women in the united states, 1998-2005.to estimate pregnancy-related mortality caused by seasonal influenza in the united states for comparison with the current 2009 influenza a h1n1 pandemic.201020410763
changing sociodemographic and clinical characteristics of tuberculosis among hiv-infected patients, new york city, 1992-2005.although highly active antiretroviral therapy (haart) has decreased human immunodeficiency virus (hiv)-related morbidity, tuberculosis remains an important disease among hiv-infected individuals.201020415570
attitudes and perceptions of the hpv vaccine in caribbean and african-american adolescent girls and their parents.to describe attitudes and perceptions toward acceptability of human papilloma virus (hpv) vaccination among inner city caribbean (ca) and african american (aa) adolescents and their parents, and discuss correlates that may be associated with these factors.201020452260
ground zero recollections of us public health service nurses deployed to new york city in september 2001.the events of september 11, 2001, set in motion the broadest emergency response ever conducted by the us department of health and human services. in this article, some of the nurses who deployed to new york city in the aftermath of that horrific attack on the united states offer their recollections of the events. although public health service commissioned corps (phs cc) officers participated in deployments before 9/11, this particular deployment accelerated the transformation of the phs cc, bec ...201020510700
mutational analysis of hoxa2 and six2 in a bronx population with isolated microtia.microtia is a developmental malformation of the external ear with genetic and environmental causes. the prevalence of microtia varies but several studies suggest increased incidence in hispanic and african american populations. no causal genetic mutations have been identified in these populations. mutations in the homeobox gene hoxa2 caused microtia in a single iranian family. another homeobox gene, six2, acts downstream of hoxa2 during development and provides another possible candidate for mut ...201020542577
fatalities associated with the 2009 h1n1 influenza a virus in new york city.background. when the 2009 h1n1 influenza a virus emerged in the united states, epidemiologic and clinical information about severe and fatal cases was limited. we report the first 47 fatal cases of 2009 h1n1 influenza in new york city. methods. the new york city department of health and mental hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 h1n1 influenza a virus. we collected basic demographic and clinical information for all patients who died and co ...201020420514
the 1918 influenza epidemic in new york city: a review of the public health response.new york city approached the 1918 influenza epidemic by making use of its existing robust public health infrastructure. health officials worked to prevent the spread of contagion by distancing healthy new yorkers from those infected, increasing disease surveillance capacities, and mounting a large-scale health education campaign while regulating public spaces such as schools and theaters. control measures, such as those used for spitting, were implemented through a spectrum of mandatory and volu ...201020568569
"better off in school": school medical inspection as a public health strategy during the 1918-1919 influenza pandemic in the united states.during the 1918-1919 influenza pandemic in the united states, most cities responded by implementing community mitigation strategies, such as school closure. however, three cities--new york city, chicago, and new haven, connecticut--diverged from the dominant pattern by keeping their public schools open while the pandemic raged. this article situates the experiences of these three cities in the broader context of the progressive era, when officials and experts put great faith in expanding public ...201020568692
expanded hiv testing and trends in diagnoses of hiv infection - district of columbia, 2004-2008.in the district of columbia (dc), the human immunodeficiency virus (hiv) case rate is nearly 10 times the u.s. rate and higher than comparable u.s. cities, such as baltimore, philadelphia, new york city, detroit, and chicago. in june 2006, the dc department of health (dcdoh) began implementing cdc's 2006 recommendations for routine, voluntary hiv screening in health-care settings. to describe recent trends in hiv disease and testing, cdc and dcdoh analyzed dc hiv case surveillance data, hiv test ...201020577154
h1n1 swine flu: the 2010 perspective--a new york academy of sciences meeting.the h1n1 swine flu: the 2010 perspective conference, held in new york city, included topics covering new research developments regarding the h1n1 influenza virus. this conference report highlights selected presentations on high-yield reassortant viral production, virus transmission and pathogenesis in ferret and guinea pig models, and the advantages of virus-like particle vaccines. fatal pathology findings from the 2009 h1n1 strain in new york, and preparedness for and response to the 2009 pande ...201020582868
urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants.need for the early identification of sepsis in very low birth weight (vlbw) infants has led to the search for reliable biomarkers. this study aims to determine whether urinary neutrophil gelatinase-associated lipocalin (ungal) rises in culture-positive sepsis and, if so, is elevated at the time sepsis is suspected. this is a prospective study of 91 vlbw infants whose urine was collected daily for ungal analysis. in 65 episodes of suspected sepsis, four groups were identified: a) culture-positive ...201020496473
laboratory surge response to pandemic (h1n1) 2009 outbreak, new york city metropolitan area, usa.the north shore-long island jewish health system laboratories serve 15 hospitals and affiliated regional physician practices in the new york city metropolitan area, with virus testing performed at a central reference laboratory. the influenza a pandemic (h1n1) 2009 outbreak began in this area on april 24, 2009, and within weeks respiratory virus testing increased 7.5 times. in response, laboratory and client service workforces were increased, physical plant build-out was completed, testing parad ...201020031036
point counterpoint: mandatory flu vaccination for health care workers. 201020032660
point counterpoint: mandatory flu vaccination for health care workers. 201020032661
point counterpoint: mandatory flu vaccination for health care workers. 201020032662
pulsed-field gel electrophoresis diversity of human and bovine clinical salmonella isolates.pulsed-field gel electrophoresis (pfge) characterization of 335 temporally and spatially matched clinical, bovine, and human salmonella enterica subsp. enterica isolates revealed 167 xbai pfge patterns. these isolates were previously classified into 51 serotypes and 73 sequence types, as determined by multilocus sequence typing. discriminatory power of pfge (simpson's index, d = 0.991) was considerably higher than that of multilocus sequence typing (d = 0.920) or serotyping (d = 0.913). although ...201020180633
burden of influenza-related hospitalizations among children with sickle cell disease.children with sickle cell disease (scd) are considered to be at high risk for complications from influenza infection despite minimal published data that characterize the burden of influenza in this population. our objectives were to (1) estimate the rate of influenza-related hospitalizations (irhs) among children with scd, (2) compare this rate with rates of children with cystic fibrosis (cf) and children with neither scd nor cf, and (3) explore mechanisms that underlie these potentially prevent ...201020100764
rapid influenza a testing for novel h1n1: point-of-care performance.the 2009 outbreak of novel influenza a h1n1 reached a pandemic status on june 11, 2009. early detection is a key factor for management and infection-control practices. recent studies have suggested a difference in performance of rapid influenza kits for influenza a h1n1. our goal was to evaluate the performance of the quickvue influenza a+b test (quidel corp., san diego, ca) in an emergency department setting and determine the most current epidemiologic trends in our community.201020107286
h1n1 influenza: contact investigation burden because of failure to institute influenza precautions in patients with negative rapid influenza diagnostic test results. 201019968491
is use of the human papillomavirus vaccine among female college students related to human papillomavirus knowledge and risk perception?few studies have examined factors associated with the actual use of the human papillomavirus (hpv) vaccine since licensure in 2006. the aims of this study were to assess hpv vaccination rates and to examine whether knowledge and risk perceptions regarding hpv were associated with the reported use of the hpv vaccine among female college students.201019841004
use of multiple-locus variable number tandem repeat analysis and phage typing for subtyping of salmonella enteritidis from sporadic human cases in the united states.to investigate the genetic diversity among s. enteritidis isolates from different geographic regions to evaluate the relationship between phage types (pts) and variable number tandem repeat analysis (vntr) loci.201019709332
changes in the sociocultural reality of chinese immigrants: challenges and opportunities in help-seeking behaviour.this paper uses findings from a larger study to present a nuanced depiction of the interplay of informal and formal help-seeking processes of a sample of chinese immigrants in their mental healthcare in new york city.201019651695
the second american cough conference. 201019636621
the development and implementation of a user-friendly priority setting tool for hiv care and treatment services in new york city.the ryan white human immunodeficiency virus (hiv) program is the largest federal program designed to provide medical and social support services for hiv infected persons who are uninsured or underinsured. in 2008, the ryan white budget was $2.2 billion, of which over $100 million went to the new york city (nyc) eligible metropolitan area (ema), which receives the largest ryan white allocation targeted to any ema. the nyc department of health and mental hygiene (dohmh) is the grantee for the ema. ...201120593229
human parainfluenza virus type 3 (hpiv 3) viral community-acquired pneumonia (cap) mimicking swine influenza (h1n1) during the swine flu pandemic.the swine influenza (h1n1) pandemic began in mexico in 2009 and quickly spread worldwide. during the h1n1 pandemic, many patients were admitted to the winthrop-university hospital with influenza-like illnesses (ilis). many hospitalized adults had h1n1 pneumonia diagnosed by laboratory or clinical criteria. however, the laboratory diagnosis of h1n1 was problematic. the rapid influenza (quickvue a/b [quidel, san diego, ca]) test frequently showed false-negative results. reverse transcriptase-polym ...201120888645
occurrence of bisphenol a in indoor dust from two locations in the eastern united states and implications for human exposures.bisphenol a (bpa) is used in the production of polycarbonate plastics and epoxy resins, which are used in many consumer products. sources of human exposures to bpa include packaged and canned food products, indoor air, and dust ingestion. information on the relative contributions of the pathways to bpa exposures is limited. in this study, we measured concentrations bpa in indoor dust collected from two locations in the eastern united states and evaluated the contribution of dust to total bpa exp ...201121221962
effectiveness of the voices/voces sexually transmitted disease/human immunodeficiency virus prevention intervention when administered by health department staff: does it work in the "real world"?prevention providers wonder whether benefits achieved in the original, researcher-led, efficacy trials of interventions are replicated when the intervention is delivered in real-world settings by their agency's staff.201120729794
patient history and physician suspicion accurately exclude pregnancy.reliance upon patient assessment in excluding pregnancy is questionable. physicians are encouraged to obtain pregnancy tests in all women of childbearing age. we affirmed the accuracy of women and their physicians in predicting pregnancy.201120825808
patient-provider communication and human papillomavirus vaccine acceptance.the authors performed telephone interviews of parents of adolescents (n = 430) and their older adolescents (n = 208) in monroe county, new york to measure parent and adolescent acceptance of human papillomavirus (hpv) vaccine, its association with ratings of provider communication, and vaccine-related topics discussed with the adolescent's provider. more than half of adolescent girls had already received an hpv vaccination, with fewer than one quarter refusing. parent and teen ratings of provide ...201120837607
sexual partner characteristics, serodiscordant/serostatus unknown unprotected anal intercourse and disclosure among human immunodeficiency virus-infected and uninfected black men who have sex with men in new york city.: black men who have sex with men (msm) are disproportionately infected with human immunodeficiency virus (hiv) in the united states. this study describes sexual partner characteristics and disclosure of hiv serostatus and evaluates factors associated with sexual risk behaviors during last sex among black msm.201121217419
barriers and facilitators to implementing primary stroke center policy in the united states: results from 4 case study states.we identified barriers and facilitators to the state-level implementation of primary stroke center (psc) policies, which encourage the certification or designation of specialized stroke treatment facilities and may address concerns such as transportation bypass, telemedicine, and treatment protocols.201121233430
factors associated with the risk of west nile virus among crows in new york state.west nile virus (wnv) is transmitted between avian hosts in enzootic cycles by a mosquito vector. the virus has significant disease effects on humans and equines when it bridges into an epizootic cycle. as the initial epidemic of wnv in 1999, perennial outbreaks in new york state suggest the local establishment of natural foci with perpetuation of the virus among susceptible hosts rather than reintroduction of the virus. the factors that play a role in the perpetuation of the virus are not fully ...201120707862
vitamin d status and antibody levels to common viruses in pediatric-onset multiple sclerosis.the relative contribution and interaction of risk factors for multiple sclerosis (ms) have not been evaluated. objectives: to determine whether vitamin d status is associated with antibody levels to common viruses in pediatric-onset ms or clinically isolated syndrome (cis) patients and controls.201121212086
intracystic papillary carcinoma of the breast: an in situ or invasive tumor? results of immunohistochemical analysis and clinical follow-up.intracystic papillary carcinoma (ipc) is regarded as an intraductal neoplasm, but recent evidence suggests that it could be invasive, as it often lacks myoepithelial lining. we evaluated myoepithelial cells and collagen iv, a basement membrane component, in 40 ipcs from 39 (35 female and 4 male) patients and assessed their clinical management and follow-up. the mean patient age at diagnosis was 68 years, and the mean tumor size was 1.8 cm. thirteen cases were pure ipc, 8 cases were ipc with or w ...201121084964
modeling spatial variations of black carbon particles in an urban highway-building environment.highway-building environments are prevalent in metropolitan areas. this paper presents our findings in investigating pollutant transport in a highway-building environment by combing field measurement and numerical simulations. we employ and improve the comprehensive turbulent aerosol dynamics and gas chemistry (ctag) model to simulate the spatial variations of black carbon (bc) concentrations near highway i-87 and an urban school in the south bronx, new york. the results of ctag simulations are ...201122084971
Evaluating the combined effectiveness of influenza control strategies and human preventive behavior.Control strategies enforced by health agencies are a major type of practice to contain influenza outbreaks. Another type of practice is the voluntary preventive behavior of individuals, such as receiving vaccination, taking antiviral drugs, and wearing face masks. These two types of practices take effects concurrently in influenza containment, but little attention has been paid to their combined effectiveness. This article estimates this combined effectiveness using established simulation models ...201122043275
pneumothorax in a young man in brooklyn, new york. 201122080120
Molting success of Ixodes scapularis varies among individual blood meal hosts and species.The blacklegged tick (Ixodes scapularis) is an important vector of emerging human pathogens. It has three blood-feeding stages, as follows: larva, nymph, and adult. Owing to inefficient transovarial transmission, at least for the Lyme disease agent (Borrelia burgdorferi), larval ticks rarely hatch infected, but they can acquire infection during their larval blood meal. Nymphal ticks are primarily responsible for transmitting pathogens to hosts, including humans. The transition from uninfected ho ...201121845946
Serum and follicular fluid ghrelin levels negatively reflect human oocyte quality and in vitro embryo development.To characterize serum and follicular fluid (FF) ghrelin in women undergoing assisted reproduction and to evaluate ghrelin's impact on ovarian steroidogenesis, oocyte quality, and embryo development.201121924713
spatial patterns of mercury in biota of adirondack, new york lakes.we studied the spatial distribution patterns of mercury (hg) in lake water, littoral sediments, zooplankton, crayfish, fish, and common loons in 44 lakes of the adirondacks of new york state, usa, a region that has been characterized as a "biological hg hotspot". our study confirmed this pattern, finding that a substantial fraction of the lakes studied had fish and loon samples exceeding established criteria for human and wildlife health. factors accounting for the spatial variability of hg in l ...201121691858
comparison of health outcomes among affiliated and lay disaster volunteers enrolled in the world trade center health registry.volunteers (non-professional rescue/recovery workers) are universally present at man-made and natural disasters and share experiences and exposures with victims. little is known of their disaster-related health outcomes.201121930152
stem cells. where do human eggs come from? 201121980085
molecular detection of viral causes of encephalitis and meningitis in new york state.the etiology of encephalitis and meningitis, serious diseases of the central nervous system (cns), in most cases remains unknown. the importance of establishing a diagnosis however, becomes even more important as advances are made in effective therapy. molecular methods of detection, in particular, pcr, are being used routinely and have established a place in the arsenal of tools for diagnosis of cns infections. in this study a viral etiological agent was detected by pcr in 340 of the total 2,35 ...201122012726
a community mobilizes to end medical apartheid.problem: people of color suffer worse health outcomes than their white counterparts due, in part, to limited access to high-quality specialty care. purpose: this article describes the events that led to the bronx health reach coalition's decision to file a civil rights complaint with the new york state office of the attorney general alleging that three academic medical centers in new york city discriminated on the basis of payer status and race in violation of title vi of the civil rights ...201122080781
fate of perchlorate in a man-made reflecting pond following a fireworks display in albany, new york, usa.perchlorate is a widespread contaminant in aquatic environments. despite this, the aquatic environmental fate of perchlorate released from fireworks displays is not well known. in the present study, we examined the fate of perchlorate in man-made reflecting ponds, from 2008 to 2010, following three fireworks displays in albany, new york, usa. immediately after the fireworks display, perchlorate in pond waters increased significantly, with concentrations from 30 to 1,480 times higher than the bas ...201121850663
agents of human anaplasmosis and lyme disease at camp ripley, minnesota.the transmission dynamics of anaplasma phagocytophilum (ap) and borrelia burgdorferi (bb) among ixodes scapularis (is) and mammalian hosts was investigated at camp ripley, an area representative of central minnesota. prevalence of white-footed mouse infection with ap and bb were 20% and 42%, respectively, with a coinfection level of 14%. peak levels of infection with both agents occurred in may. the average levels of seropositivity to ap and bb were 29.3% and 48%, respectively. of the mice infec ...201121867420
inotropic contractile reserve can risk-stratify patients with hiv cardiomyopathy: a dobutamine stress echocardiography study.the purpose of this study was to assess whether inotropic contractile reserve (icr) during dobutamine stress echocardiography (dse) could risk-stratify patients with human immunodeficiency virus (hiv) cardiomyopathy and predict improvement of left ventricular ejection fraction (lvef).201122172778
predictive mapping of human risk for west nile virus (wnv) based on environmental and socioeconomic factors.a west nile virus (wnv) human risk map was developed for suffolk county, new york utilizing a case-control approach to explore the association between the risk of vector-borne wnv and habitat, landscape, virus activity, and socioeconomic variables derived from publically available datasets. results of logistic regression modeling for the time period between 2000 and 2004 revealed that higher proportion of population with college education, increased habitat fragmentation, and proximity to wnv po ...201121853103
acute illnesses associated with insecticides used to control bed bugs--seven states, 2003--2010.the common bed bug, cimex lectularius, is a wingless, reddish-brown insect that requires blood meals from humans, other mammals, or birds to survive. bed bugs are not considered to be disease vectors, but they can reduce quality of life by causing anxiety, discomfort, and sleeplessness. bed bug populations and infestations are increasing in the united states and internationally. bed bug infestations often are treated with insecticides, but insecticide resistance is a problem, and excessive use o ...201121937972
a randomized trial of a behavioral intervention for black men who have sex with men: the dish study.objective:: to test a new behavioral intervention for black men who have sex with men in reducing sexual risk and increasing social support and intentions to use condoms. design:: a single site, unblinded randomized trial in new york city with 3-month follow-up. methods:: participants (n = 283) reporting at least 2 sexual partners and unprotected anal intercourse with a man in the past 3 months were enrolled and randomized to a social-cognitive theory based intervention or control comparison. me ...201122156967
polybrominated diphenyl ethers (pbdes), polychlorinated biphenyls (pcbs) and neuropsychological status among older adults in new york.polybrominated diphenyl ethers (pbdes) are emerging environmental contaminants, but little is known about their possible human health effects. the objective of this study is to evaluate the association between exposure to pbdes and neuropsychological function among older adults and the possibility of effect modification with polychlorinated biphenyls (pcbs). serum samples were analyzed for concentrations of 9 pbde and 30 pcb congeners and 34 tests of cognitive and motor function, affective state ...201122079442
The impact of missed opportunities on seasonal influenza vaccination coverage for healthy young children.To estimate the impact of missed opportunities on influenza vaccination coverage among 6- through 23-month-old children who sought medical care during the 2004-2005 influenza season.201121964369
in vivo facial tissue depth study of chinese-american adults in new york city.this study examines facial tissue depth in adult chinese-americans. using ultrasound, measurements were taken at 19 landmarks across the faces of 101 individuals aged from 18 to 87 years. summary statistics are reported for a sample of 67 individuals of normal weight (as determined by a body mass index [bmi] of 19-25). statistical analyses were used to assess relationships between tissue thickness, age, and bmi. results indicate that no significant relationship exists between tissue thickness an ...201121210802
temporally structured metapopulation dynamics and persistence of influenza a h3n2 virus in humans.populations of seasonal influenza virus experience strong annual bottlenecks that pose a considerable extinction risk. it has been suggested that an influenza source population located in tropical southeast or east asia seeds annual temperate epidemics. here we investigate the seasonal dynamics and migration patterns of influenza a h3n2 virus by analysis of virus samples obtained from 2003 to 2006 from australia, europe, japan, new york, new zealand, southeast asia, and newly sequenced viruses f ...201122084096
limb venous compliance responses to lower body negative pressure in humans with high blood pressure.this study tested the hypothesis that limb venous responses to baroreceptor unloading are altered in individuals with high blood pressure (hbp) compared with normotensive (nt) controls. calf venous compliance was assessed in 20 subjects with prehypertension and stage-1 hypertension (mean arterial pressure, map: 104±1 mm hg) and 13 nt controls (map: 86±2 mm hg) at baseline and during lower body negative pressure (lbnp), using venous occlusion plethysmography. baroreflex sensitivity (brs) was meas ...201121471995
frequency and clinicopathologic correlates of kras amplification in non-small cell lung carcinoma.background: characterization of the non-small cell lung cancer (nsclc) genome has suggested that kras amplification is one of the commonest molecular abnormalities in nsclc. however, the prevalence and clinicopathologic significance of kras amplification, and its relationship with kras activating mutations have not been well-defined. the purpose of this study was to establish the prevalence of kras amplification in two separate, large nsclc cohorts, to define the clinicopathologic features of kr ...201121477882
increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis.objectives: patients with congenital bicuspid aortic valves have aortic valve stenosis at a relatively young age compared with patients with tricuspid aortic valves. we hypothesize that aortic valve stenosis evolves from a more aggressive inflammatory process, with increased macrophage/t-cell and neovessel content in congenital bicuspid aortic valveswhen compared with that seen in tricuspid valves. methods: fifty-one severely stenotic aortic valves were obtained at the time of aortic valve repla ...201121481422
c-reactive protein, interleukin-6, and posttraumatic stress disorder symptomology in urban police officers.our aim was to examine the relationship between the level of the inflammatory markers, c-reactive protein (crp) and interleukin-6 (il-6), and posttraumatic stress disorder (ptsd) symptomology in a random sample of 115 police officers. crp was measured in citrated plasma using a particle enhanced immunonepholometric assay and il-6 was measured in serum with a solid-phase quantitative sandwich elisa. the presence of high ptsd symptomology was defined as having an impact of event scale score (ies) ...201121493089
elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve.to investigate the association between elevated body mass index (bmi) and ovarian reserve.201121529798
an innovative approach to interdisciplinary occupational safety and health education.the new york and new jersey education and research center (erc) provides a range of graduate continuing education for occupational safety and health (osh) professionals in training. a key element of the education is to provide interdisciplinary training to industrial hygienists, ergonomists, occupational medicine physicians and other health and safety trainees to prepare them for the collaboration required to solve the complex occupational health and safety problems they will face in their caree ...201121557281
associations between herpes simplex virus type 2 and hcv with hiv among injecting drug users in new york city.objectives. we examined relationships between herpes simplex virus type 2 (hsv-2), a biomarker for sexual risk, and hcv, a biomarker for injecting risk, with hiv among injecting drug users (idus) who began injecting after large-scale expansion of syringe exchange programs in new york city. methods. we recruited 337 heroin and cocaine users who began injecting in 1995 or later from persons entering drug detoxification. we administered a structured interview covering drug use and hiv risk behavior ...201121566021
the ultimate benefit to be derived from the epidemic. 201121750280
interview: commercial translation of cell-based therapies and regenerative medicine: learning by experience.dr haseltine speaks to emily culme-seymour, assistant commissioning editor william a haseltine, phd has an active career in both science and business. he was a professor at harvard medical school and harvard school of public health (ma, usa) from 1976 to 1993, where he was founder and chair of two academic research departments. he is well known for his pioneering work on cancer, hiv/aids and genomics. he has authored more than 200 manuscripts in peer-reviewed journals and is the author of severa ...201121749201
testing. claims by man who falsely thought he had hiv may proceed. 201121585003
pik3ca mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression.pik3ca gene mutations are the most common activating mutations in human breast cancer. its association with hormone receptor-positive breast cancer makes it a prime target for clinical therapeutic advances to maintain anti-estrogen responsiveness. in anticipation of this therapeutic approach, we have evaluated intratumoral heterogeneity in primary breast cancers with regard to pik3ca mutation status. in addition, we have assessed for the presence of the mutation in paired pre-invasive breast can ...201121617917
single nucleotide polymorphisms in dna repair genes and association with breast cancer risk in the web study.base excision and nucleotide excision repair pathways repair damaged dna, and polymorphisms in these genes might affect breast cancer susceptibility. we evaluated associations between 7 single nucleotide polymorphisms (snps) in 4 dna repair genes (ercc4 rs1799801, xpc rs2227998, rs2228001, rs2228000, ogg1 rs1052133, and xrcc1 rs25487 and rs25486) and breast cancer risk, examining modification by smoking and alcohol consumption, using data from the western new york exposures and breast cancer (we ...201121622940
hiv-infected hospitalized patients with 2009 pandemic influenza a (ph1n1)--united states, spring and summer 2009.we describe the clinical findings of hiv-infected patients hospitalized with 2009 pandemic influenza a (ph1n1). data were derived from 3 separate case series in the united states. among 911 adults hospitalized with ph1n1 influenza, 31 (3.4%) were hiv infected compared with an hiv prevalence of 0.45% in the general us adult population. hiv-infected influenza patients experienced similar rates of intensive care unit admission (29% vs 34%) and death (13% vs 13%) compared with non-hiv-infected patie ...201121342893
epidemiology of 2009 pandemic influenza a (h1n1) deaths in the united states, april-july 2009.during the spring of 2009, pandemic influenza a (h1n1) virus (ph1n1) was recognized and rapidly spread worldwide. to describe the geographic distribution and patient characteristics of ph1n1-associated deaths in the united states, the centers for disease control and prevention requested information from health departments on all laboratory-confirmed ph1n1 deaths reported from 17 april through 23 july 2009. data were collected using medical charts, medical examiner reports, and death certificates ...201121342901
soul whisperers.personal recollections are offered in reflection upon the tragedy of 9/11. the outreach efforts of the blanton-peale institute in conjunction with the health care chaplaincy of new york and the red cross are recalled by ceo emeritus, kathryn madden. a brief clinical study describes the responses of a young man who was one of only a few persons to make it out of the north tower from above the 85th floor. blanton-peale's benefit honorees brian clark, lauren and greg manning are named as survivors ...201121826557
sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response.background: sunitinib has activity in patients with metastatic urothelial cancer (uc), but most patients do not respond. objective: to identify predictors of response to sunitinib. design, setting, and participants: seventy-seven patients with advanced uc received sunitinib on one of two schedules at a single institution. blood pressure (bp), immunohistochemistry (ihc), and pharmacokinetic (pk) results were correlated with response to sunitinib. measurements: bp was assessed on day 1 and 28 of e ...201121645967
'it was a freak accident': an analysis of the labelling of injury events in the us press.objectives given that the news media shape our understanding of health issues, a study was undertaken to examine the use by the us media of the expression 'freak accident' in relation to injury events. this analysis is intended to contribute to the ongoing consideration of lay conceptualisation of injuries as 'accidents'. methods lexisnexis academic was used to search three purposively selected us news sources (associated press, new york times and philadelphia inquirer) for the expression 'freak ...201121659441
distributions of polyhalogenated compounds in hudson river (new york, usa) fish in relation to human uses along the river.pcbs (as aroclor concentrations) have been extensively examined in fish along the hudson river, but other xenobiotic chemicals in fish have had limited assessment. this study determined concentrations and congener distributions of polybrominated diphenyl ethers (pbdes), polybrominated and polychlorinated dibenzo-p-dioxins and dibenzofurans (pbdd/fs and pcdd/fs), and polychlorinated biphenyls (pcbs) in smallmouth bass and striped bass taken from a 385km reach of the hudson river. concentrations o ...201121742424
human health risk assessment of synthetic turf fields based upon investigation of five fields in connecticut.questions have been raised regarding possible exposures when playing sports on synthetic turf fields cushioned with crumb rubber. rubber is a complex mixture with some components possessing toxic and carcinogenic properties. exposure is possible via inhalation, given that chemicals emitted from rubber might end up in the breathing zone of players and these players have high ventilation rates. previous studies provide useful data but are limited with respect to the variety of fields and scenarios ...201121797769
hiv-2 infection surveillance --- united states, 1987--2009.human immunodeficiency virus (hiv) is categorized into two types, hiv-1 and hiv-2. worldwide, most hiv infections are hiv-1, whereas hiv-2 largely has been confined to persons in or from west africa. hiv-1 and hiv-2 have the same routes of transmission, and both can cause acquired immunodeficiency syndrome (aids); however, hiv-2 infections should be differentiated from hiv-1 infections because they are less likely to cause aids and their clinical management differs. cdc's current surveillance ca ...201121796096
sexual transmission of hepatitis c virus among hiv-infected men who have sex with men --- new york city, 2005--2010.in the united states, an estimated 3.2 million persons are living with hepatitis c virus (hcv) infection. hcv transmission occurs primarily through percutaneous exposure to blood, and persons who inject drugs are at greatest risk for infection. the role of sexual transmission of hcv has not been well defined. however, reports over the past decade, mainly from europe, have implicated sexual transmission of hcv among human immunodeficiency virus (hiv)--infected men who have sex with men (msm). in ...201121775948
exposure to lymphocytic choriomeningitis virus, new york, usa.to the editor: lymphocytic choriomeningitis virus (lcmv) is an arenavirus carried by the house mouse, mus musculus. human infections can range from mild febrile illness to severe encephalitis and disseminated disease (1). infection during pregnancy is associated with teratogenic effects, including congenital hydrocephalus and chorioretinitis (2).201121762607
lead, mercury, cadmium, chromium, and arsenic levels in eggs, feathers, and tissues of canada geese of the new jersey meadowlands.the new jersey meadowlands are located within the heavily urbanized new york/new jersey harbor estuary and have been subject to contamination due to effluent and runoff from industry, traffic, and homes along the hackensack river and nearby waterways. these extensive wetlands, though heavily impacted by development and pollution, support a wide array of bird and other wildlife species. persistent contaminants may pose threats to birds in these habitats, affecting reproduction, egg hatchability, ...201121679937
factors associated with unprotected exposure to 2009 h1n1 influenza a among healthcare workers during the first wave of the pandemic.protecting healthcare workers (hcws) from occupational exposure to 2009 h1n1 influenza was a challenge. during the first wave of the pandemic, many hcws reported that they had been exposed to 2009 h1n1 when they were not using respiratory personal protective equipment. unprotected exposures tended to be more frequent among hcws caring for patients with atypical clinical presentations.201121460517
exome sequencing identified myo1e and neil1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.to identify gene loci associated with steroid-resistant nephrotic syndrome (srns), we utilized homozygosity mapping and exome sequencing in a consanguineous pedigree with three affected siblings. high-density genotyping identified three segments of homozygosity spanning 33.6ôçëmb on chromosomes 5, 10, and 15 containing 296 candidate genes. exome sequencing identified two homozygous missense variants within the chromosome 15 segment; an a159p substitution in myosin 1e (myo1e), encoding a podocyte ...201121697813
barriers to hiv testing among hiv/aids concurrently diagnosed persons in new york city.: to assess barriers to human immunodeficiency virus (hiv) testing, health care contacts history, and hiv testing history among patients diagnosed concurrently with hiv and acquired immunodeficiency syndrome (aids).201121844723
a survival analysis approach to modeling human fecundity.understanding conception probabilities is important not only for helping couples to achieve pregnancy but also in identifying acute or chronic reproductive toxicants that affect the highly timed and interrelated processes underlying hormonal profiles, ovulation, libido, and conception during menstrual cycles. currently, 2 statistical approaches are available for estimating conception probabilities depending upon the research question and extent of data collection during the menstrual cycle: a su ...201121697247
decelerating spread of west nile virus by percolation in a heterogeneous urban landscape.vector-borne diseases are emerging and re-emerging in urban environments throughout the world, presenting an increasing challenge to human health and a major obstacle to development. currently, more than half of the global population is concentrated in urban environments, which are highly heterogeneous in the extent, degree, and distribution of environmental modifications. because the prevalence of vector-borne pathogens is so closely coupled to the ecologies of vector and host species, this het ...201121829332
intervention to influence behaviors linked to risk of chronic diseases: a multisite randomized controlled trial with african-american hiv-serodiscordant heterosexual couples.background: the high morbidity and mortality in african americans associated with behavior-linked chronic diseases are well documented. methods: we tested the efficacy of an intervention to increase multiple health-related behaviors in african americans. in a multisite cluster-randomized controlled trial, groups of african american human immunodeficiency virus (hiv)-serodiscordant heterosexual couples in atlanta (georgia), los angeles (california), new york (new york), and philadelphia (pennsylv ...201121518939
agent-based simulation for weekend-extension strategies to mitigate influenza outbreaks.abstract:201121718518
predictors of acceptance of h1n1 influenza vaccination by fdny firefighters and ems workers.there is a widely recognized need for vaccination of health care workers (hcws). we undertook this study to assess the 2009-2010 h1n1 vaccination rates in ôê+14,000 firefighters and emergency medical service (ems) workers at the fire department of new york (fdny) and to determine predictors of h1n1 vaccine acceptance.201121693157
first reports of human rotavirus g8p[4] gastroenteritis in the united states.in 2009, three children were hospitalized in rochester, ny with sequence-confirmed g8p[4] rotavirus gastroenteritis-the first us detection of this uncommon strain more typically found in africa. continued monitoring of g8p[4] and other rotavirus genotypes not represented in current vaccines is essential to assess whether vaccination will result in an increase in prevalence of these strains.201122170918
association of rad51 polymorphism with dna repair in brca1 mutation carriers and sporadic breast cancer risk.abstract:201121708019
The Rockefeller University Hospital (1910-2010): creating the science of medicine.The year 2010 marked the centennial of the Rockefeller University Hospital, one of the great philanthropic achievements of 20th-century science. For 100 years, the Hospital played a central role in the development and growth of medical science by enabling physician-scientists to make intensive study of human biology and disease. With ingenuity and devotion, they greatly enriched clinical medicine as well as basic biological science. This account emphasizes the founding and first half-century of ...201121857122
Promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism.Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation. We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study. Real-time methylation-specific PCR was perform ...201121916701
Fish consumption, low-level mercury, lipids, and inflammatory markers in children.There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9-11 year old children (N=100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Childre ...201122030286
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