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robert j. doherty, nysda president 2010-2011. humor becomes the man from white plains. 201020863036
factors associated with the ability and willingness of essential workers to report to duty during a pandemic.to determine essential workers' ability and willingness to report to duty during a serious pandemic outbreak and to identify modifiable risk factors.201020881624
a source, a cascade, a schizoid: a heuristic proposal from the longitudinal study of personality disorders.it is argued that personality pathology represents the final emergent product of a complex interaction of underlying neurobehavioral systems as well as environment inputs. a number of factors may be involved in the developmental pathway and a cascading of effects is plausible, although a unifying cascade for all personality disorders is not likely. the present study suggests a possible cascade relevant to one personality disorder: schizoid personality disorder in emerging adulthood. in brief, it ...201020883587
progress in prevention of mother-to-child transmission of hiv in new york state: 1988-2008.to assess the outcomes of efforts to prevent mother-to-child transmission (mtct) of human immunodeficiency virus (hiv) made over the last 2 decades in new york state (nys), through review of data from multiple sources.201020885177
program and policy interventions for preventing mother-to-child transmission of hiv in new york state.mother-to-child transmission (mtct) of human immunodeficiency virus has been virtually eliminated in new york state (nys) in a relatively short time. the dramatic reduction in mtct was achieved through a comprehensive public health program that maximized the benefits of advances in both diagnosis and treatment of hiv infection. the multifaceted program encompassed interventions at multiple levels. it mobilized and engaged medical providers, and it changed clinical practice and the health care de ...201020885178
syringe exchange programs --- united states, 2008.persons who inject drugs should use a new, sterile needle and syringe for each injection. syringe exchange programs (seps) provide free sterile syringes and collect used syringes from injection-drug users (idus) to reduce transmission of bloodborne pathogens, including human immunodeficiency virus (hiv), hepatitis b virus, and hepatitis c virus (hcv). as of march 2009, a total of 184 seps were known to be operating in 36 states, the district of columbia (dc), and puerto rico (north american syri ...201021085091
linking emergency preparedness and health care worker vaccination against influenza: a novel approach.health care workers (hcws) can acquire and transmit influenza to their patients and coworkers, even while asymptomatic. the u.s. healthy people 2010 initiative set a national goal of 60% coverage for hcw influenza vaccination by 2010. yet vaccination rates remain low. in the 2008-2009 influenza season, flushing hospital medical center (fhmc; new york) adopted a "push/pull" point-of-dispensing (pod) vaccination model that was derived from emergency preparedness planning for mass vaccination and/o ...201021090019
peak cardiac power measured noninvasively with a bioreactance technique is a predictor of adverse outcomes in patients with advanced heart failure.peak oxygen consumption (vo(2) ) during cardiopulmonary exercise testing (cpet) is a powerful predictor of survival, providing an indirect assessment of cardiac output (co). noninvasive indices of co derived from bioreactance methodology would add significantly to peak vo(2) as a means of risk-stratifying patients with heart failure. in this study, 127 patients (53 ± 14 years of age, 66% male) with heart failure and an average ejection fraction of 31% ± 15% underwent symptom-limited cpet using a ...201021091609
workforce training and education gaps in gerontology and geriatrics: what we found in new york state.this article summarizes data from the 2008 symposium charting the future for new york state workforce training and education in aging: the stakeholder perspective and the 2009 report workforce training and education: the challenge for academic institutions. this research is the outcome of a collaborative state society on aging of new york and new york state office for the aging study on new york state's workforce training and education needs. eight listening sessions were held across new york st ...201021108099
hospitalizations for tuberculosis in new york city: how many could be avoided?to determine which factors were associated with hospitalization for tuberculosis (tb) in new york city (nyc), united states, and to estimate the proportion of potentially avoidable admissions.201021144247
achieving international targets for tuberculosis treatment success among hiv-positive patients in new york city.to review outcomes of human immunodeficiency virus (hiv) positive tuberculosis (tb) patients in new york city (nyc) to determine if the world health organization treatment success target of 85% was met in a setting with ready access to treatment for hiv and tb.201021144248
characterization of interleukin-17-producing regulatory t cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.interleukin (il)-17-producing cd4(+) helper t cells (th17) mediate mucosal immunity and are involved in the pathogenesis of inflammatory bowel disease (ibd). they are believed to arise from the same precursor population as regulatory t (treg) cells, but little is known about how these t-cell subsets interact under chronic inflammatory conditions. we studied th17 and treg cells isolated from intestinal lamina propria of patients with ibd to investigate their role in pathogenesis.201021147109
infectious syphilis among adolescent and young adult men: implications for human immunodeficiency virus transmission and public health interventions.background:: in 2008, an increase in syphilis among young black men was noted in new york city (nyc), miami-fort lauderdale, and philadelphia. to explore this trend, we examined infectious syphilis cases from 2000 to 2008 among adolescent and young adult men in these areas. methods:: descriptive analysis of male infectious syphilis cases reported to public health authorities in nyc, fl, and philadelphia. results:: from 2000 to 2008, infectious syphilis cases among males increased in nyc (107-102 ...201021150816
infectious chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma.neutrophilic asthma is thought to be less responsive than eosinophilic asthma to anti-inflammatory therapies including corticosteroids. chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (il-8). we hypothesized that il-8 is increased in the bronchoalveolar lavage (bal) fluid from children with asthma and c. pneumoniae.201021155094
a tribute to seymour steven brody: in memoriam (november 29, 1927 to may 25, 2010).we honor steve brody, a dear friend and a mentor on what would have been his 83rd birthday (november 29, 2010). steve was a pioneer of chlorophyll structure and function, an outstanding biophysicist, an innovator, an artist and an adventurer, a true renaissance man. we present here first his first-of-a-kind contributions on the primary processes of photosynthesis at the university of illinois at urbana-champaign, and then review his research on the interactions of chlorophyll monolayers and vari ...201021161598
influenza vaccination and its impact on hospitalization events in nursing homes.objectives: to examine trends of influenza vaccination in nursing homes before and after public reporting (objective-1), and to assess the effect of influenza vaccinations on hospitalization events (objective-2). research design: nursing home compare (nhc) database was used to obtain influenza vaccination rates during the 2005-2006, 2006-2007, and 2007-2008 flu seasons (objective-1). the 2005-2007 minimum data set for new york state (nys) was obtained and linked with the nhc data (objective-2). ...201021450172
quantitative risk assessment of the new york state operated west valley radioactive waste disposal area.this article is based on a quantitative risk assessment (qra) that was performed on a radioactive waste disposal area within the western new york nuclear service center in western new york state. the qra results were instrumental in the decision by the new york state energy research and development authority to support a strategy of in-place management of the disposal area for another decade. the qra methodology adopted for this first of a kind application was a scenario-based approach in the fr ...201020412517
organotin compounds, including butyltins and octyltins, in house dust from albany, new york, usa.organotin compounds (ots) have been used in a wide variety of consumer products. despite this, very few studies have reported the occurrence of ots in house dust or exposure of humans to ots through the ingestion of house dust. in the present study, concentrations of monobutyltin (mbt), dibutyltin (dbt), tributyltin (tbt), monooctyltin (mot), dioctyltin (dot), trioctyltin (tot), diphenyltin (dpt), and triphenyltin (tpt) were measured in dust collected from 24 houses in albany, new york, usa. in ...201020379706
estimation of the incubation period of influenza a (h1n1-2009) among imported cases: addressing censoring using outbreak data at the origin of importation.empirical estimates of the incubation period of influenza a (h1n1-2009) have been limited. we estimated the incubation period among confirmed imported cases who traveled to japan from hawaii during the early phase of the 2009 pandemic (n=72). we addressed censoring and employed an infection-age structured argument to explicitly model the daily frequency of illness onset after departure. we assumed uniform and exponential distributions for the frequency of exposure in hawaii, and the hazard rate ...201021168422
lichen sclerosus: epidemiological distribution in an equal access health care system.the incidence and demographics of lichen sclerosus range from 1/300 (0.3%) to 1/1,000 individuals (0.1%). we analyzed the incidence of lichen sclerosus in an equal access health care system, hypothesizing that it is more common in older white males.201021168879
long-term posttraumatic stress symptoms among 3,271 civilian survivors of the september 11, 2001, terrorist attacks on the world trade center.although the september 11, 2001, terrorist attacks were the largest human-made disaster in us history, there is little extant research documenting the attacks' consequences among those most directly affected, that is, persons who were in the world trade center towers. data from a cross-sectional survey conducted 2-3 years after the attacks ascertained the prevalence of long-term, disaster-related posttraumatic stress symptoms and probable posttraumatic stress disorder (ptsd) in 3,271 civilians w ...201021190987
simultaneous identification of mycobacterial isolates to the species level and determination of tuberculosis drug resistance by pcr followed by electrospray ionization mass spectrometry.mycobacterium tuberculosis that is resistant to both isoniazid (inh) and rifampin (rif) is spreading. it has become a public health problem in part because the standard culture methods used to determine the appropriate treatment regimen for patients often take months following the presumptive diagnosis of tuberculosis. furthermore, the misidentification of nontuberculosis mycobacteria (ntm) in patients presumably suffering from tuberculosis results in additional human and health care costs. the ...201021191060
barriers to mask wearing for influenza-like illnesses among urban hispanic households.to identify barriers to mask wearing and to examine the factors associated with the willingness to wear masks among households.201021198810
the first national pain medicine summit--final summary report.pain is ubiquitous. at some point in time it affects everyone. for many millions pain becomes chronic, a scourge that impacts every facet of life-work, hobbies, family relations, social fabric, finances, happiness, mood, and even the very essence of identity. according to the national institutes of health (nih), pain is one of our most important national public health problems, a silent epidemic. in 1998, nih reported that the annual amount spent on health care, compensation, and litigation rela ...201021199301
mass commuting and influenza vaccination prevalence in new york city: protection in a mixing environment.assess influenza vaccination among commuters using mass transit in new york city (nyc).201021218159
exploratory assessment of perfluorinated compounds and human thyroid function.thyroid hormones play critical roles in human neurodevelopment and adult neurocognitive function. persistent organohalogen pollutants, such as perfluorinated compounds (pfcs), may interfere with thyroid homeostasis and thus exposures to these compounds might represent risk factors for neurologic and cognitive abnormalities. in this study, serum specimens collected from thirty-one licensed anglers in new york state were analyzed for levels of thyroid stimulating hormone (tsh), free thyroxine (ft( ...201019419669
recent trends for colorectal cancer screening in hiv-infected patients.we planned to investigate the recent trends for colorectal cancer (crc) screening in human immunodeficiency virus (hiv) as compared to non-hiv by interviewing consecutive patients in outpatient clinics during september 2007. out of a total of 300 patients interviewed, 205 met the inclusion criteria. one hundred and fourteen were hiv-infected, while 91 were non-hiv. hiv received more office visits per year. despite the high incidence of adenomas on screening colonoscopy, hiv patients were less li ...201019283477
the second american cough conference. 201019636621
real men do...real men don't: young latino and african american men's discourses regarding sexual health care utilization.there is growing recognition that men as well as women need sexual health care (shc) services. despite this, male friendly sexual health services are not readily available in the united states, and men are underutilizing the services that are available. this situation needs to be rectified to improve sexual health outcomes for men and women. in this study we conducted 10 focus groups with young adult latino and african american men to examine their perceptions of the factors influencing shc util ...201019477755
is use of the human papillomavirus vaccine among female college students related to human papillomavirus knowledge and risk perception?few studies have examined factors associated with the actual use of the human papillomavirus (hpv) vaccine since licensure in 2006. the aims of this study were to assess hpv vaccination rates and to examine whether knowledge and risk perceptions regarding hpv were associated with the reported use of the hpv vaccine among female college students.201019841004
common genetic variations in the lep and lepr genes, obesity and breast cancer incidence and survival.obesity is a strong risk factor for breast cancer in postmenopausal women and adverse prognostic indicator regardless of menopausal status. leptin is an important regulator of adipose tissue mass and has been associated with tumor cell growth. leptin exerts its effects through interaction with the leptin receptor (lepr). we investigated whether genetic variations in the leptin (lep) and lepr genes are associated with risk of breast cancer, or once diagnosed, with survival. the polymorphisms lep ...201019697123
use of multiple-locus variable number tandem repeat analysis and phage typing for subtyping of salmonella enteritidis from sporadic human cases in the united states.to investigate the genetic diversity among s. enteritidis isolates from different geographic regions to evaluate the relationship between phage types (pts) and variable number tandem repeat analysis (vntr) loci.201019709332
changes in the sociocultural reality of chinese immigrants: challenges and opportunities in help-seeking behaviour.this paper uses findings from a larger study to present a nuanced depiction of the interplay of informal and formal help-seeking processes of a sample of chinese immigrants in their mental healthcare in new york city.201019651695
occurrence of bisphenol a in indoor dust from two locations in the eastern united states and implications for human exposures.bisphenol a (bpa) is used in the production of polycarbonate plastics and epoxy resins, which are used in many consumer products. sources of human exposures to bpa include packaged and canned food products, indoor air, and dust ingestion. information on the relative contributions of the pathways to bpa exposures is limited. in this study, we measured concentrations bpa in indoor dust collected from two locations in the eastern united states and evaluated the contribution of dust to total bpa exp ...201121221962
barriers and facilitators to implementing primary stroke center policy in the united states: results from 4 case study states.we identified barriers and facilitators to the state-level implementation of primary stroke center (psc) policies, which encourage the certification or designation of specialized stroke treatment facilities and may address concerns such as transportation bypass, telemedicine, and treatment protocols.201121233430
rabid foxes, rabid raccoons, and the odds of a human bite exposure, new york state, 1999-2007.anecdotal evidence suggests that rabid foxes are more likely to attack humans than are other rabid terrestrial animals. to examine this issue, we analyzed rabies surveillance data (1999-2007) maintained by the new york state department of health. compared to rabid raccoons (procyon lotor), foxes infected with raccoon variant rabies were more likely to bite during a human exposure incident (p<0.01). additionally, rabid gray foxes (urocyon cinereoargenteus) were significantly more likely to bite a ...201121270014
individual- and neighborhood-level characteristics associated with support of in-pharmacy vaccination among esap-registered pharmacies: pharmacists' role in reducing racial/ethnic disparities in influenza vaccinations in new york city.new york state (nys) passed legislation authorizing pharmacists to administer immunizations in 2008. racial/socioeconomic disparities persist in vaccination rates and vaccine-preventable diseases such as influenza. many nys pharmacies participate in the expanded syringe access program (esap), which allows provision of non-prescription syringes to help prevent transmission of hiv, and are uniquely positioned to offer vaccination services to low-income communities. to understand individual and nei ...201121279450
incident hepatitis c virus infection among us hiv-infected men enrolled in clinical trials.outbreaks of sexually transmitted hepatitis c virus (hcv) infection have been reported among human immunodeficiency virus (hiv)-infected men who have sex with men in europe, australia, and new york. whether this is occurring across the united states is unknown.201121282184
norman garmezy (1918-2009).norman garmezy, a pioneer in research on risk and resilience, died in nashville, tennessee, on november 21, 2009, at the age of 91. he was a legendary mentor as well as an eminent scientist in clinical psychology. norm was born on june 18, 1918, in new york city and grew up in the bronx in a jewish neighborhood where educational attainment was highly valued. the scientific study of resilience as conceived by norman garmezy, his peers, and students has transformed the science and practice of mult ...201121299255
text message reminders to promote human papillomavirus vaccination.to implement and evaluate text message reminders for the second (hpv2) and third (hpv3) vaccine doses.201121300094
sexual behaviors of adolescent emerging and young adult men who have sex with men ages 13-29 in new york city.hiv infections among young men who have sex with men (ymsm), ages 13-29 in new york city have been steadily increasing over the last decade.201121317586
evaluation of hiv incidence surveillance in new york city, 2006.in 2005, the new york city (nyc) department of health and mental hygiene implemented a standardized human immunodeficiency virus (hiv) incidence surveillance protocol based on the serologic testing algorithm for recent hiv seroconversion deployed nationwide by the centers for disease control and prevention (cdc). we evaluated four key attributes of nyc's hiv incidence surveillance system-simplicity, data quality, timeliness, and acceptability--using cdc's guidelines for surveillance system evalu ...201121337929
closing schools in response to the 2009 pandemic influenza a h1n1 virus in new york city: economic impact on households.understanding the effectiveness of a school closure in limiting social interaction and the economic impact of school closure on households is critical when developing guidelines to prevent spread of pandemic influenza. a new york city survey conducted in june 2009 in 554 households affected by the 2009 pandemic influenza h1n1-related school closures showed that, during closure, 30% of students visited at least 1 locale outside their homes. if all the adults in the home were employed, an ill chil ...201121342890
hiv-infected hospitalized patients with 2009 pandemic influenza a (ph1n1)--united states, spring and summer 2009.we describe the clinical findings of hiv-infected patients hospitalized with 2009 pandemic influenza a (ph1n1). data were derived from 3 separate case series in the united states. among 911 adults hospitalized with ph1n1 influenza, 31 (3.4%) were hiv infected compared with an hiv prevalence of 0.45% in the general us adult population. hiv-infected influenza patients experienced similar rates of intensive care unit admission (29% vs 34%) and death (13% vs 13%) compared with non-hiv-infected patie ...201121342893
epidemiology of 2009 pandemic influenza a (h1n1) deaths in the united states, april-july 2009.during the spring of 2009, pandemic influenza a (h1n1) virus (ph1n1) was recognized and rapidly spread worldwide. to describe the geographic distribution and patient characteristics of ph1n1-associated deaths in the united states, the centers for disease control and prevention requested information from health departments on all laboratory-confirmed ph1n1 deaths reported from 17 april through 23 july 2009. data were collected using medical charts, medical examiner reports, and death certificates ...201121342901
public engagement on new york state's plan for allocating ventilators during a pandemic. 201121353914
protecting the public from h1n1 through points of dispensing (pods).in fall 2009, the new york city department of health and mental hygiene (dohmh) operated 58 points of dispensing (pods) over 5 weekends to provide influenza a (h1n1) 2009 monovalent vaccination to new yorkers. up to 7 sites were opened each day across the 5 boroughs, with almost 50,000 new yorkers being vaccinated. the policies and protocols used were based on those developed for new york city's pod plan, the cornerstone of the city's mass prophylaxis planning. before the h1n1 experience, nyc ha ...201121361797
dental shape match rates in selected and orthodontically treated populations in new york state: a two-dimensional study.forensically identifying a suspect's dentition from a bitemark in an open population requires the supposition that every person's dental alignment is different. there have been few studies that have tested this claim. four hundred and ten lower anterior dentitions from a selected population and 110 lower anterior dentitions from one that was orthodontically treated were measured using geometric morphometric analysis, allowing comparison of arch shape. dental match rates of 1.46% and 42.7% of ind ...201121361951
human papillomavirus vaccine uptake and barriers: association with perceived risk, actual risk and race/ethnicity among female students at a new york state university, 2010.understanding human papillomavirus (hpv) vaccine uptake patterns is critical to improve vaccination levels. approximately half (56%) of female undergraduate students surveyed at a large public university reported hpv vaccine series initiation, with 79% of initiators completing the three dose series. predictors of series initiation included having a conversation with a health-care provider about the vaccine, reporting a history of sexual intercourse and receipt of the meningitis vaccine. compared ...201121376797
shorter anogenital distance predicts poorer semen quality in young men in rochester, new york.in male rodents, anogenital distance (agd) provides a sensitive and continuous correlate of androgen exposure in the intrauterine environment and predicts later reproductive success. some endocrine-disrupting chemicals can alter male reproductive tract development, including shortening agd, in both rodents and humans. whether agd is related to semen quality in human is unknown.201121377950
perceptions of and willingness to engage in public health precautions to prevent 2009 h1n1 influenza transmission.recommendations about precautionary behaviors are a key part of public health responses to infectious disease threats such as the 2009 h1n1 pandemic. individuals' interpretation of recommendations, willingness to comply, and factors predicting willingness were examined.201121385436
health care workers and swine flu. 201121402821
hiv transmitted from a living organ donor--new york city, 2009.routine screening of organ donors for human immunodeficiency virus (hiv) infection has made transmission of hiv through organ transplantation rare in the united states. however, despite routine screening, transmission of hiv can be an uncommon complication of organ transplantation and is a public health concern. in 2010, the new york city (nyc) department of health and mental hygiene (nyc dohmh) was notified of a potential transplant-related hiv infection. this report summarizes the results of t ...201121412210
henry jacob bigelow (1818-1890): his contributions to anatomy and surgery.there have been many advances in the medical world over time that have greatly contributed to ameliorating and prolonging human life. the employment of surgical anesthesia is arguably one of the greatest medical discoveries of all time, and has immensely broadened our ability to treat the ill. while dr. henry jacob bigelow (1818-1890) was not the inventor of anesthesia, he was the first to publish and advocate its use in the 19th century (bigelow and bigelow [1894] a memoir of henry jacob bigelo ...201121412854
women's knowledge and awareness of gynecologic cancer: a multisite qualitative study in the united states.u.s. women's awareness and knowledge of gynecologic cancer have not been well studied, with the exception of cervical cancer screening and risk factors.201121413897
comparative assessment of human exposure to phthalate esters from house dust in china and the united states.because of volatilization and leaching from their application in consumer and personal care products, phthalate esters are ubiquitous contaminants in the indoor environment. in this study, we measured concentrations and profiles of 9 phthalate esters in indoor dust samples collected from six cities in china (n = 75). for comparison, we also analyzed samples collected from albany, new york, usa (n = 33). the results indicated that concentrations, except for dicyclohexyl phthalate (dchp) and bis(2 ...201121434628
vitamin d status and antibody levels to common viruses in pediatric-onset multiple sclerosis.the relative contribution and interaction of risk factors for multiple sclerosis (ms) have not been evaluated. objectives: to determine whether vitamin d status is associated with antibody levels to common viruses in pediatric-onset ms or clinically isolated syndrome (cis) patients and controls.201121212086
sexual partner characteristics, serodiscordant/serostatus unknown unprotected anal intercourse and disclosure among human immunodeficiency virus-infected and uninfected black men who have sex with men in new york city.: black men who have sex with men (msm) are disproportionately infected with human immunodeficiency virus (hiv) in the united states. this study describes sexual partner characteristics and disclosure of hiv serostatus and evaluates factors associated with sexual risk behaviors during last sex among black msm.201121217419
in vivo facial tissue depth study of chinese-american adults in new york city.this study examines facial tissue depth in adult chinese-americans. using ultrasound, measurements were taken at 19 landmarks across the faces of 101 individuals aged from 18 to 87 years. summary statistics are reported for a sample of 67 individuals of normal weight (as determined by a body mass index [bmi] of 19-25). statistical analyses were used to assess relationships between tissue thickness, age, and bmi. results indicate that no significant relationship exists between tissue thickness an ...201121210802
use of low-dose steroids in decreasing cytokine release during bilateral total knee replacement.interleukin 6 (il-6), a marker of inflammation, is one of the major cytokines released during joint replacement. in the orthopedic patient population, high levels have been linked to many adverse effects including acute respiratory distress syndrome, postoperative mental status changes, and fever. we looked to assess the efficacy of low-dose steroids on the postinflammatory response as measured by il-6 in patients undergoing bilateral total knee replacement (btkr). the role of steroids has never ...201121455087
factors associated with unprotected exposure to 2009 h1n1 influenza a among healthcare workers during the first wave of the pandemic.protecting healthcare workers (hcws) from occupational exposure to 2009 h1n1 influenza was a challenge. during the first wave of the pandemic, many hcws reported that they had been exposed to 2009 h1n1 when they were not using respiratory personal protective equipment. unprotected exposures tended to be more frequent among hcws caring for patients with atypical clinical presentations.201121460517
limb venous compliance responses to lower body negative pressure in humans with high blood pressure.this study tested the hypothesis that limb venous responses to baroreceptor unloading are altered in individuals with high blood pressure (hbp) compared with normotensive (nt) controls. calf venous compliance was assessed in 20 subjects with prehypertension and stage-1 hypertension (mean arterial pressure, map: 104±1 mm hg) and 13 nt controls (map: 86±2 mm hg) at baseline and during lower body negative pressure (lbnp), using venous occlusion plethysmography. baroreflex sensitivity (brs) was meas ...201121471995
frequency and clinicopathologic correlates of kras amplification in non-small cell lung carcinoma.background: characterization of the non-small cell lung cancer (nsclc) genome has suggested that kras amplification is one of the commonest molecular abnormalities in nsclc. however, the prevalence and clinicopathologic significance of kras amplification, and its relationship with kras activating mutations have not been well-defined. the purpose of this study was to establish the prevalence of kras amplification in two separate, large nsclc cohorts, to define the clinicopathologic features of kr ...201121477882
increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis.objectives: patients with congenital bicuspid aortic valves have aortic valve stenosis at a relatively young age compared with patients with tricuspid aortic valves. we hypothesize that aortic valve stenosis evolves from a more aggressive inflammatory process, with increased macrophage/t-cell and neovessel content in congenital bicuspid aortic valveswhen compared with that seen in tricuspid valves. methods: fifty-one severely stenotic aortic valves were obtained at the time of aortic valve repla ...201121481422
c-reactive protein, interleukin-6, and posttraumatic stress disorder symptomology in urban police officers.our aim was to examine the relationship between the level of the inflammatory markers, c-reactive protein (crp) and interleukin-6 (il-6), and posttraumatic stress disorder (ptsd) symptomology in a random sample of 115 police officers. crp was measured in citrated plasma using a particle enhanced immunonepholometric assay and il-6 was measured in serum with a solid-phase quantitative sandwich elisa. the presence of high ptsd symptomology was defined as having an impact of event scale score (ies) ...201121493089
random anti-müllerian hormone (amh) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels.to investigate the utility of random anti-müllerian hormone (amh) in assessing ovarian response among women with diminished ovarian reserve (dor) diagnosed by elevated early follicular-phase fsh levels.201121497340
intervention to influence behaviors linked to risk of chronic diseases: a multisite randomized controlled trial with african-american hiv-serodiscordant heterosexual couples.background: the high morbidity and mortality in african americans associated with behavior-linked chronic diseases are well documented. methods: we tested the efficacy of an intervention to increase multiple health-related behaviors in african americans. in a multisite cluster-randomized controlled trial, groups of african american human immunodeficiency virus (hiv)-serodiscordant heterosexual couples in atlanta (georgia), los angeles (california), new york (new york), and philadelphia (pennsylv ...201121518939
elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve.to investigate the association between elevated body mass index (bmi) and ovarian reserve.201121529798
an innovative approach to interdisciplinary occupational safety and health education.the new york and new jersey education and research center (erc) provides a range of graduate continuing education for occupational safety and health (osh) professionals in training. a key element of the education is to provide interdisciplinary training to industrial hygienists, ergonomists, occupational medicine physicians and other health and safety trainees to prepare them for the collaboration required to solve the complex occupational health and safety problems they will face in their caree ...201121557281
associations between herpes simplex virus type 2 and hcv with hiv among injecting drug users in new york city.objectives. we examined relationships between herpes simplex virus type 2 (hsv-2), a biomarker for sexual risk, and hcv, a biomarker for injecting risk, with hiv among injecting drug users (idus) who began injecting after large-scale expansion of syringe exchange programs in new york city. methods. we recruited 337 heroin and cocaine users who began injecting in 1995 or later from persons entering drug detoxification. we administered a structured interview covering drug use and hiv risk behavior ...201121566021
testing. claims by man who falsely thought he had hiv may proceed. 201121585003
pik3ca mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression.pik3ca gene mutations are the most common activating mutations in human breast cancer. its association with hormone receptor-positive breast cancer makes it a prime target for clinical therapeutic advances to maintain anti-estrogen responsiveness. in anticipation of this therapeutic approach, we have evaluated intratumoral heterogeneity in primary breast cancers with regard to pik3ca mutation status. in addition, we have assessed for the presence of the mutation in paired pre-invasive breast can ...201121617917
single nucleotide polymorphisms in dna repair genes and association with breast cancer risk in the web study.base excision and nucleotide excision repair pathways repair damaged dna, and polymorphisms in these genes might affect breast cancer susceptibility. we evaluated associations between 7 single nucleotide polymorphisms (snps) in 4 dna repair genes (ercc4 rs1799801, xpc rs2227998, rs2228001, rs2228000, ogg1 rs1052133, and xrcc1 rs25487 and rs25486) and breast cancer risk, examining modification by smoking and alcohol consumption, using data from the western new york exposures and breast cancer (we ...201121622940
sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response.background: sunitinib has activity in patients with metastatic urothelial cancer (uc), but most patients do not respond. objective: to identify predictors of response to sunitinib. design, setting, and participants: seventy-seven patients with advanced uc received sunitinib on one of two schedules at a single institution. blood pressure (bp), immunohistochemistry (ihc), and pharmacokinetic (pk) results were correlated with response to sunitinib. measurements: bp was assessed on day 1 and 28 of e ...201121645967
'it was a freak accident': an analysis of the labelling of injury events in the us press.objectives given that the news media shape our understanding of health issues, a study was undertaken to examine the use by the us media of the expression 'freak accident' in relation to injury events. this analysis is intended to contribute to the ongoing consideration of lay conceptualisation of injuries as 'accidents'. methods lexisnexis academic was used to search three purposively selected us news sources (associated press, new york times and philadelphia inquirer) for the expression 'freak ...201121659441
human health risk assessment of synthetic turf fields based upon investigation of five fields in connecticut.questions have been raised regarding possible exposures when playing sports on synthetic turf fields cushioned with crumb rubber. rubber is a complex mixture with some components possessing toxic and carcinogenic properties. exposure is possible via inhalation, given that chemicals emitted from rubber might end up in the breathing zone of players and these players have high ventilation rates. previous studies provide useful data but are limited with respect to the variety of fields and scenarios ...201121797769
hiv-2 infection surveillance --- united states, 1987--2009.human immunodeficiency virus (hiv) is categorized into two types, hiv-1 and hiv-2. worldwide, most hiv infections are hiv-1, whereas hiv-2 largely has been confined to persons in or from west africa. hiv-1 and hiv-2 have the same routes of transmission, and both can cause acquired immunodeficiency syndrome (aids); however, hiv-2 infections should be differentiated from hiv-1 infections because they are less likely to cause aids and their clinical management differs. cdc's current surveillance ca ...201121796096
sexual transmission of hepatitis c virus among hiv-infected men who have sex with men --- new york city, 2005--2010.in the united states, an estimated 3.2 million persons are living with hepatitis c virus (hcv) infection. hcv transmission occurs primarily through percutaneous exposure to blood, and persons who inject drugs are at greatest risk for infection. the role of sexual transmission of hcv has not been well defined. however, reports over the past decade, mainly from europe, have implicated sexual transmission of hcv among human immunodeficiency virus (hiv)--infected men who have sex with men (msm). in ...201121775948
exposure to lymphocytic choriomeningitis virus, new york, usa.to the editor: lymphocytic choriomeningitis virus (lcmv) is an arenavirus carried by the house mouse, mus musculus. human infections can range from mild febrile illness to severe encephalitis and disseminated disease (1). infection during pregnancy is associated with teratogenic effects, including congenital hydrocephalus and chorioretinitis (2).201121762607
the ultimate benefit to be derived from the epidemic. 201121750280
interview: commercial translation of cell-based therapies and regenerative medicine: learning by experience.dr haseltine speaks to emily culme-seymour, assistant commissioning editor william a haseltine, phd has an active career in both science and business. he was a professor at harvard medical school and harvard school of public health (ma, usa) from 1976 to 1993, where he was founder and chair of two academic research departments. he is well known for his pioneering work on cancer, hiv/aids and genomics. he has authored more than 200 manuscripts in peer-reviewed journals and is the author of severa ...201121749201
soul whisperers.personal recollections are offered in reflection upon the tragedy of 9/11. the outreach efforts of the blanton-peale institute in conjunction with the health care chaplaincy of new york and the red cross are recalled by ceo emeritus, kathryn madden. a brief clinical study describes the responses of a young man who was one of only a few persons to make it out of the north tower from above the 85th floor. blanton-peale's benefit honorees brian clark, lauren and greg manning are named as survivors ...201121826557
distributions of polyhalogenated compounds in hudson river (new york, usa) fish in relation to human uses along the river.pcbs (as aroclor concentrations) have been extensively examined in fish along the hudson river, but other xenobiotic chemicals in fish have had limited assessment. this study determined concentrations and congener distributions of polybrominated diphenyl ethers (pbdes), polybrominated and polychlorinated dibenzo-p-dioxins and dibenzofurans (pbdd/fs and pcdd/fs), and polychlorinated biphenyls (pcbs) in smallmouth bass and striped bass taken from a 385km reach of the hudson river. concentrations o ...201121742424
lead, mercury, cadmium, chromium, and arsenic levels in eggs, feathers, and tissues of canada geese of the new jersey meadowlands.the new jersey meadowlands are located within the heavily urbanized new york/new jersey harbor estuary and have been subject to contamination due to effluent and runoff from industry, traffic, and homes along the hackensack river and nearby waterways. these extensive wetlands, though heavily impacted by development and pollution, support a wide array of bird and other wildlife species. persistent contaminants may pose threats to birds in these habitats, affecting reproduction, egg hatchability, ...201121679937
exome sequencing identified myo1e and neil1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.to identify gene loci associated with steroid-resistant nephrotic syndrome (srns), we utilized homozygosity mapping and exome sequencing in a consanguineous pedigree with three affected siblings. high-density genotyping identified three segments of homozygosity spanning 33.6ôçëmb on chromosomes 5, 10, and 15 containing 296 candidate genes. exome sequencing identified two homozygous missense variants within the chromosome 15 segment; an a159p substitution in myosin 1e (myo1e), encoding a podocyte ...201121697813
barriers to hiv testing among hiv/aids concurrently diagnosed persons in new york city.: to assess barriers to human immunodeficiency virus (hiv) testing, health care contacts history, and hiv testing history among patients diagnosed concurrently with hiv and acquired immunodeficiency syndrome (aids).201121844723
a survival analysis approach to modeling human fecundity.understanding conception probabilities is important not only for helping couples to achieve pregnancy but also in identifying acute or chronic reproductive toxicants that affect the highly timed and interrelated processes underlying hormonal profiles, ovulation, libido, and conception during menstrual cycles. currently, 2 statistical approaches are available for estimating conception probabilities depending upon the research question and extent of data collection during the menstrual cycle: a su ...201121697247
decelerating spread of west nile virus by percolation in a heterogeneous urban landscape.vector-borne diseases are emerging and re-emerging in urban environments throughout the world, presenting an increasing challenge to human health and a major obstacle to development. currently, more than half of the global population is concentrated in urban environments, which are highly heterogeneous in the extent, degree, and distribution of environmental modifications. because the prevalence of vector-borne pathogens is so closely coupled to the ecologies of vector and host species, this het ...201121829332
agent-based simulation for weekend-extension strategies to mitigate influenza outbreaks.abstract:201121718518
predictors of acceptance of h1n1 influenza vaccination by fdny firefighters and ems workers.there is a widely recognized need for vaccination of health care workers (hcws). we undertook this study to assess the 2009-2010 h1n1 vaccination rates in ôê+14,000 firefighters and emergency medical service (ems) workers at the fire department of new york (fdny) and to determine predictors of h1n1 vaccine acceptance.201121693157
association of rad51 polymorphism with dna repair in brca1 mutation carriers and sporadic breast cancer risk.abstract:201121708019
heat shock factor y chromosome (hsfy) mrna level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia.to evaluate heat shock factor y chromosome (hsfy) mrna as a biomarker for the presence of retrievable testicular sperm.201121676392
spatial patterns of mercury in biota of adirondack, new york lakes.we studied the spatial distribution patterns of mercury (hg) in lake water, littoral sediments, zooplankton, crayfish, fish, and common loons in 44 lakes of the adirondacks of new york state, usa, a region that has been characterized as a "biological hg hotspot". our study confirmed this pattern, finding that a substantial fraction of the lakes studied had fish and loon samples exceeding established criteria for human and wildlife health. factors accounting for the spatial variability of hg in l ...201121691858
The Rockefeller University Hospital (1910-2010): creating the science of medicine.The year 2010 marked the centennial of the Rockefeller University Hospital, one of the great philanthropic achievements of 20th-century science. For 100 years, the Hospital played a central role in the development and growth of medical science by enabling physician-scientists to make intensive study of human biology and disease. With ingenuity and devotion, they greatly enriched clinical medicine as well as basic biological science. This account emphasizes the founding and first half-century of ...201121857122
Promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism.Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation. We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study. Real-time methylation-specific PCR was perform ...201121916701
predictive mapping of human risk for west nile virus (wnv) based on environmental and socioeconomic factors.a west nile virus (wnv) human risk map was developed for suffolk county, new york utilizing a case-control approach to explore the association between the risk of vector-borne wnv and habitat, landscape, virus activity, and socioeconomic variables derived from publically available datasets. results of logistic regression modeling for the time period between 2000 and 2004 revealed that higher proportion of population with college education, increased habitat fragmentation, and proximity to wnv po ...201121853103
Fish consumption, low-level mercury, lipids, and inflammatory markers in children.There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9-11 year old children (N=100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Childre ...201122030286
acute illnesses associated with insecticides used to control bed bugs--seven states, 2003--2010.the common bed bug, cimex lectularius, is a wingless, reddish-brown insect that requires blood meals from humans, other mammals, or birds to survive. bed bugs are not considered to be disease vectors, but they can reduce quality of life by causing anxiety, discomfort, and sleeplessness. bed bug populations and infestations are increasing in the united states and internationally. bed bug infestations often are treated with insecticides, but insecticide resistance is a problem, and excessive use o ...201121937972
Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among children.Perchlorate, nitrate and thiocyanate are ubiquitous in the environment, and human exposure to these chemicals is accurately measured in urine. Biomarkers of these chemicals represent a person's recent exposure, however, little is known on the temporal variability of the use of a single measurement of these biomarkers. Healthy Hispanic and Black children (6-10-year-old) donated urine samples over 6 months. To assess temporal variability, we used three statistical methods (n=29; 153 urine samples) ...201122166811
bat rabies and human postexposure prophylaxis, new york, usa. 201122172493
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