Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| polychlorinated dibenzo-p-dioxins and related compounds: the blood levels of young japanese women. | we investigated pcdds and related compounds in the blood of young japanese women, approximately 20 years of age, who had not yet had children, and discussed how the teq level of pcdds and related compounds in their blood may affect the next generation. means of total teq levels were 0.063 pg/g for whole blood basis and 21 pg/g for lipid basis. teq of pcdds, pcdfs and coplanar pcbs accounted for about 43, 34 and 23% of the total teq in the whole blood basis, respectively. in the lipid basis, thei ... | 1999 | 10365432 |
| wavelength dependence of ultraviolet-induced dna damage distribution: involvement of direct or indirect mechanisms and possible artefacts. | dna damage profiles have been established in plasmid dna using purified dna repair enzymes and a plasmid relaxation assay, following exposure to uvc, uvb, uva or simulated sunlight (ssl). cyclobutane pyrimidine dimers (cpds) are revealed as t4 endonuclease v-sensitive sites, oxidation products at purine and pyrimidine as fpg- and nth-sensitive sites, and abasic sites are detected by nfo protein from escherichia coli. cpds are readily detected after uva exposure, though produced 10(3) and 10(5) t ... | 1999 | 10365447 |
| serum lipoproteins and apolipoprotein e in infants with congenital hypothyroidism. | hypothyroid adults have a high risk of atherosclerosis, secondary to increased levels of various cholesterol fractions, particularly low-density lipoprotein cholesterol (ldl-c). we investigated the existence of a correlation between thyroid hormone deficiency and serum lipoproteins and a possible effect of different apolipoprotein e (apoe) phenotypes on lipoprotein levels in 75 infants with hypothyroidism. | 1999 | 10365572 |
| subclinical hypothyroidism in a biethnic, urban community. | to evaluate the association between hypothyroidism, and the health status of older hispanic and non-hispanic white (nhw) men and women. to accomplish this, we determined the prevalences of the treated and untreated conditions and examined the associations between an elevated serum thyroid stimulating hormone (tsh) and cognitive and affective (mood) functions and the prevalences of symptoms and comorbidity, specifically coronary heart disease (chd), diabetes, hypertension, and hyperlipidemia. | 1999 | 10366170 |
| thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus. | an association between insulin-dependent diabetes mellitus (iddm) and autoimmune thyroid disease is well recognized. we have studied the prevalence of thyroid dysfunction, autoimmunity and morphological abnormalities by ultrasonography in young diabetics. | 1999 | 10366407 |
| analysis of capsid portal protein and terminase functional domains: interaction sites required for dna packaging in bacteriophage t4. | bacteriophage dna packaging results from an atp-driven translocation of concatemeric dna into the prohead by the phage terminase complexed with the portal vertex dodecamer of the prohead. functional domains of the bacteriophage t4 terminase and portal gene 20 product (gp20) were determined by mutant analysis and sequence localization within the structural genes. interaction regions of the portal vertex and large terminase subunit (gp17) were determined by genetic (terminase-portal intergenic sup ... | 1999 | 10366503 |
| endoscopic ultrasound and fine needle aspiration for the evaluation of pancreatic masses. | endoscopic ultrasound (eus) and endoscopic ultrasound-guided fine needle aspiration (eus-fna) are accurate for the preoperative staging of pancreatic ductal carcinoma. | 1999 | 10367874 |
| endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of goserelin acetate administered every 13 weeks to patients with advanced prostate cancer. | to determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of zoladextrade mark (goserelin acetate, zeneca pharmaceuticals, wilmington, delaware, usa), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 weeks in patients with advanced prostate cancer. | 1999 | 10368200 |
| inhibition of escherichia coli rna polymerase by bacteriophage t7 gene 2 protein. | the 64 amino acid residue product of bacteriophage t7 gene 2 (gp2) binds the escherichia coli rna polymerase and inhibits transcription. we localized the gp2 binding site to within 53 amino acid residues in the functionally dispensable region of the rna polymerase beta' subunit. we investigated the effect of gp2 on transcription at a -10/-35 promoter and at an "extended -10" promoter. our results indicate that binding of gp2 to the sigma70holoenzyme (esigma70) prevents promoter recognition at -1 ... | 1999 | 10369763 |
| pre-operative staging of recto-sigmoid colon carcinoma by upper gastrointestinal endoscopic ultrasonography. | to assess the accuracy of a new generation endoscopic ultrasonography (eus)(gf-m200) in pre-operative staging of recto-sigmoid colon carcinoma invasion and lymph node metastasis. | 1999 | 10370633 |
| ampullary carcinoma: prognostic significance of ploidy, cell-cycle analysis and proliferating cell nuclear antigen (pcna). | the aim of the present study is to assess the nuclear dna ploidy patterns, the fraction of cells in the various phases of the cell cycle as determined by flow cytometry and to evaluate proliferative cell-nuclear antigen (pcna) expression in order to examine the relationships between phase-two molecular factors, clinicopathological aspects and outcome of patients with cancers of the ampulla of vater. | 1999 | 10370689 |
| the drop in plasma thyrotropin concentrations in fasted chickens is caused by an action at the level of the hypothalamus: role of corticosterone. | fasting has severe effects on thyroid metabolism in the chicken: plasma thyroxine (t4) concentrations increase, whereas 3',5,3-triiodothyronine (t3) concentrations decrease. in the present report we studied the effect of fasting at the level of: 1) the pituitary (plasma thyrotropin (tsh) concentrations; the sensitivity of thyrotrophs to corticotropin-releasing hormone (crh) and tsh-releasing hormone (trh)); and 2) the hypothalamus (trh content). a regulatory role of corticosterone is discussed. ... | 1999 | 10370862 |
| both atrial resection and superior vena cava replacement in sleeve pneumonectomy for advanced lung cancer. | extended sleeve pneumonectomy including removal of the superior vena cava, right atrium and parts of left atrium on cardiopulmonary bypass was successfully performed in a 40-year-old man. the tumour was histologically proven a t4 n1 stage with margins free from tumour. adjuvant radiochemotherapy was administered postoperatively on an outpatient base. the patient did well for 7 months then he died from myocardial infarction due to metastatic infiltration of the right coronary artery. other metast ... | 1999 | 10371135 |
| evaluation of early reperfusion and i.v. tpa therapy using diffusion- and perfusion-weighted mri. | to characterize the effects of recombinant tissue plasminogen activator (rt-pa) therapy and early reperfusion on diffusion-weighted (dwi) and perfusion-weighted imaging (pwi) changes observed following acute ischemic injury. | 1999 | 10371525 |
| [our experience of carcinoma of the larynx in togo]. | this is a retrospective study of 33 patients with squamous cell carcinoma of the larynx from the end ward at tokoin teaching hospital in lomé. this series is from 1981 and 1995 (1 t1, 6 t2, 15 t3, 11 t4). this is an uncommon cancer. no etiological factors were identified. the high proportion requiring emergency tracheotomy (36.36%) and of t3-t4 cases (78.78%) are explained by the long delay before the first medical visit. only 13 patients (36.36%) had a total laryngectomy. the prognosis was unfa ... | 1999 | 10371859 |
| left ventricular diastolic dysfunction in patients with subclinical hypothyroidism. | although subclinical hypothyroidism is frequently diagnosed, the decision to institute a substitutive therapy with l-t4 remains controversial. because the cardiovascular system is considered a main target for the action of thyroid hormone, we investigated whether subclinical hypothyroidism induces cardiovascular abnormalities. twenty-six patients (mean age, 36 +/- 12 yr) were evaluated by doppler-echocardiography, whereas a subgroup of 10 patients, randomly selected, were reevaluated after 6 mon ... | 1999 | 10372711 |
| functional and physical interaction between wrn helicase and human replication protein a. | the human premature aging disorder werner syndrome (ws) is associated with a large number of symptoms displayed in normal aging. the wrn gene product, a dna helicase, has been previously shown to unwind short dna duplexes (</=53 base pairs) in a reaction stimulated by single-stranded dna-binding proteins. we have studied the helicase activity of purified wrn protein on a variety of dna duplex substrates to characterize the unwinding properties of the enzyme in greater detail. wrn helicase can ca ... | 1999 | 10373438 |
| microsatellite alterations in superficial and locally advanced transitional cell carcinoma of the bladder. | recent studies described the existence of genetic instability associated with bladder carcinogenesis. alterations at microsatellite loci constitute a recognized tumor marker of genome instability. a series of 21 transitional cell carcinomas of the bladder (10 superficial and 11 invasive carcinomas) was analyzed for the presence of alteration in 12 microsatellite loci, in order to detect the role of microsatellite instability in genesis and progression of human bladder cancer. our preliminary res ... | 1999 | 10373679 |
| [assessment of sub-clinical thyroid disfunction in aged hospitalized patients in limousin]. | the aims of the study were to assess the prevalence of sub-clinical thyroid dysfunction in older patients and to analyze morphological and immunological thyroid abnormalities. subjects and methods: the effect of aging on thyroid function morphology and immunology was studied in 102 french patients (70 women and 32 men) with a mean age of 81.7 +/- 7.3 years (65-101 years). all patients were hospitalized with different pathological conditions but without any thyroid disease. patients with treatmen ... | 1999 | 10374012 |
| [thyroid hormone determination at the public assistance hospital of paris: ordering, costs and opinions of physicians qualified in endocrinology]. | to determine the distribution of orders for hormonal tests assessing thyroid function in a hospital setting. to collect the opinion of physicians specialized in endocrinology concerning free triodothyronine (ft3) assessment. | 1999 | 10374016 |
| vitiligo, autoimmune thyroiditis: a rare thyroid cancer arising with bone metastates on maxillofacial area. | an association between vitiligo and autoimmune thyroid disorders had previously been postulated. thyroid disorders were found in 18.5% of 15,126 patients with vitiligo, on the basis of the anamnestic data. then, we investigated 255 healthy relatives in whom we tested only t3, t4 and tsh. with the immunological investigation we detected a higher incidence of tma in vitiligo patients and in the family members. therefore, on the basis of the immunologic and thyroid pathology functional data, we obs ... | 1999 | 10374684 |
| unique alterations of thyroid function parameters after i.v. administration of alkylating drugs (cyclophosphamide and ifosfamide). | alkylating drugs (cyclophosphamide and ifosfamide) have been in clinical use for the treatment of malignant diseases in the past. they are most useful anticancer agents and cyclophosphamide is also widely used for its immunosuppressive properties. however the effect of alkylating drugs on thyroid hormone parameters have not been evaluated so far. three groups of patients were prospectively evaluated: group i: 15 patients with wegener's granulomatosis and 4 patients with severe scleritis received ... | 1999 | 10376442 |
| primary placement of a voice prosthesis on transposed colon after total pharyngolaryngoesophagectomy. | primary placement of a voice prosthesis may aid rehabilitation after total laryngectomy. methods: we present a rare clinical situation of a t4 no mo squamous cell carcinoma of the hypopharynx and esophagus in a patient who had previously undergone a transmesocolic billroth ii gastrectomy. | 1999 | 10376757 |
| molecular genetics of congenital hypothyroidism. | congenital thyroid gland defects - resulting in reduced production of the hormones triiodothyronine (t3) and thyroxine (t4) - can be a consequence of either reduced or absent thyroid tissue (thyroid dysgenesis) or, less frequently, of impairment in the biochemical mechanisms responsible for hormone biosynthesis (thyroid dyshormonogenesis). recent studies have revealed how mutations in the genes encoding either transcription factors or the thyroid stimulating hormone receptor cause, in humans or ... | 1999 | 10377281 |
| plasma lipoprotein (a) concentrations in hypothyroid, euthyroid and hyperthyroid subjects. | alterations of the lipid profile are a well known phenomenon in thyroid dysfunction. thyroid hormones regulate lipid metabolism through various mechanisms, but a key role is played by the ldl receptor pathway. thyroid hormone influence on lipoprotein (a) [lp(a)] metabolism is known. | 1999 | 10378018 |
| serum uric acid concentration and thyroid-stimulating-hormone (tsh): results of screening for hyperuricaemia in 2359 consecutive patients with various degrees of thyroid dysfunction. | serum uric acid concentration (sua) and hyperthyroidism have been reported to positively correlate with each other. furthermore, epidemiological data indicate that uric acid may be an independent risk factor for hypertension-associated morbidity and mortality. to evaluate whether screening for hyperuricaemia might be worthwhile in patients with hyperthyroidism we determined serum concentrations of uric acid in 2359 consecutive patients (1939 female, 420 male; age: 48 +/- 17 years, mean +/- sd) w ... | 1999 | 10378314 |
| effects of a low-calorie diet on resting metabolic rate and serum tri-iodothyronine levels in obese children. | the purpose of the study was to examine the effects of weight loss on resting metabolic rate (rmr) and on serum t3 levels in obese children and to investigate whether rmr changes are related to t3 changes. sixty-four healthy, overweight, children (age: 12.1+/-1.1 years, body mass index 29.3+/-4.3 kg/m2) were studied during a 6-week weight reduction programme. rmr (by indirect calorimetry) total t3, total t4, tsh and fat-free mass (ffm) (by anthropometry) were measured at baseline and after 6 wee ... | 1999 | 10378389 |
| differences in metallothionein expression in transplantable mouse mammary tumor lines. | in order to elucidate a possible role of metallothionein (mt) in mammary carcinogenesis, mt and sex hormone receptor (estrogen receptor, er; progesterone receptor, pr) expressions were investigated immunohistochemically in a transplantable pregnancy-dependent mouse mammary tumor (tpdmt-4) and related autonomous tumor sublines (t4-oi96, t4-oi165 and t4-oi320cy) recovered from pregnant and virgin ddd mice. tpdmt-4 showed mt expression in tumor cells, while the expression was less evident in t4-oi1 ... | 1999 | 10378789 |
| the heart rate turn point reliability and methodological aspects. | the aim of the study was to test protocol variations on the heart rate performance curve (hrpc) and the heart rate turn point (hrtp) according to conconi et al. (1996). respiratory gas exchange variables were used to define three phases of energy supply (i, ii, iii). | 1999 | 10378920 |
| serotypes and electrophoretic protein profiles of pasteurella haemolytica isolated from pneumonic ovine lungs. | serotypes and sds-page protein profiles of p. haemolytica isolated from pneumonic ovine lungs were investigated. of 268 p. haemolytica isolates, 232 (86.6%) were serotypable. a total of 12 serotypes were recognized in 20 different geographic origins of central turkey. the most common serotype was a2, followed by a7, a1 and t4. serotypes a13, a14, a16 and t15 could not be detected. in sds-page, marked differences between major bands of biotype a and t strains were found. in numerical analysis of ... | 1999 | 10379102 |
| mutation detection using fluorescent enzyme mismatch cleavage with t4 endonuclease vii. | mutation detection techniques are often limited by sensitivity, ease of use and short fragment lengths. enzyme mismatch cleavage (emc) is a technique capable of rapidly scanning 1 kbp fragments of dna for mutations. it relies on the ability of a bacteriophage resolvase enzyme, t4 endonuclease vii, to cleave dna at single base pair mismatches and small heteroduplex loops. originally the process was performed using radioactively labeled dna and the results analysed after denaturing polyacrylamide ... | 1999 | 10380755 |
| intestinal damage induced by zinc deficiency is associated with enhanced cuzn superoxide dismutase activity in rats: effect of dexamethasone or thyroxine treatment. | zinc has a wide spectrum of biological activities and its deficiency has been related to various tissue dysfunctions and alterations of normal cell metabolism. zinc also plays an important role in the antioxidant cellular defenses being a structural element of the non-mitochondrial form of the enzyme superoxide dismutase (cuznsod). we have already reported that zn deficiency induces severe alterations in the rat intestine, that are reverted by treatment with dexamethasone (dex) or thyroxine (t4) ... | 1999 | 10381190 |
| serum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin concentrations in epileptic dogs treated with anticonvulsants. | to determine whether administration of phenobarbital, potassium bromide, or both drugs concurrently was associated with abnormalities in baseline serum total thyroxine (t4), triiodothyronine (t3), free t4, or thyrotropin (thyroid-stimulating hormone; tsh) concentrations in epileptic dogs. | 1999 | 10382022 |
| solitary nodular disease and multinodular goiter: a retrospective study on suppressive versus replacement levothyroxine therapy. | the aim of the present study was to ascertain whether patients affected by solitary nodular disease of the thyroid or multinodular goiter had a different clinical outcome when treated with suppressive levo-thyroxine (l-t4) therapy rather than replacement l-t4 therapy. we evaluated, by a retrospective analysis, 36 patients who had received tsh-suppressive l-t4 therapy according to tsh value and 55 who had received replacement l-t4 therapy. fine needle aspiration cytology and thyroid scan after 13 ... | 1999 | 10382684 |
| thoracic pedicle screw placement guided by computed tomographic measurements. | cadaveric pedicle screw placement guided by the measurements from axial computed tomography (ct) scans in the thoracic spine was assessed in this study. axial ct scans were performed on four cadaveric thoracic spines, and the measurements included the pedicle transverse angle, inner pedicle width, and distance between the midline of the vertebra and the pedicle axis on the dorsal aspect of the lamina. with utilization of the data from ct scans, screws were directly placed into the thoracic pedic ... | 1999 | 10382775 |
| palatoalveolar outcome at 18 months following simultaneous primary cleft lip repair and posterior palatoplasty. | it is frequently reported that early repair of the soft palate induces narrowing of the remaining palatal cleft and thus facilitates later hard palate closure. however, to the best of our knowledge, there have been no comparative studies to test this hypothesis. the purpose of this retrospective study was to evaluate the change of palatoalveolar morphology following primary lip repair and posterior palatoplasty. dental plaster models of patients with complete unilateral cleft of lip and palate ( ... | 1999 | 10382792 |
| persistent efficacy of doramectin pour-on against artificially induced infections of nematodes in cattle. | two studies were conducted to determine the persistent efficacy of doramectin pour-on against an artificial, trickle challenge of mixed nematodes in calves. in each study, 42, 4-8 months old calves were randomly assigned into four groups of 10 animals each (t1-t4), plus two larval-viability monitor animals. all animals were treated with fenbendazole (10 mg kg(-1)) 14 days prior to the start of the study to clear any existing infection. doramectin pour-on at 500 microg kg(-1) was used on each ani ... | 1999 | 10384905 |
| molecular typing of erythromycin-resistant streptococcus pyogenes strains with the m phenotype isolated in italy. | to assess the spread of the new m phenotype, various erythromycin-resistant streptococcus pyogenes strains from three italian cities (verona, monza, florence) were characterised. each strain was analysed for the presence of genes ermam and mefa, for the ability to accumulate radioactive erythromycin in the absence of sodium arsenate, for the protein t serological type, and for the dna macrorestriction profile identified by means of pulsed-field gel electrophoresis. in a number of strains, the pr ... | 1999 | 10385014 |
| mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome p-450 2b1 mrna: role of epidermal growth factor and perivenous oxygen tension. | treatment of male rats with phenobarbital (pb) results in a perivenous and mid-zonal pattern of cytochrome p-450 (cyp)2b1 mrna expression within the liver acinus. the mechanism of this zonated induction is still poorly understood. in this study sinusoidal gradients of oxygen and epidermal growth factor (egf) besides those of the pituitary-dependent hormones growth hormone (gh), thyroxine (t4), and triiodothyronine (t3) were considered to be possible determinants for the zonated induction of the ... | 1999 | 10385683 |
| increased rate of complete eus staging of patients with esophageal cancer using the nonoptical, wire-guided echoendoscope. | incomplete endoscopic ultrasound (eus) staging procedures in patients with esophageal cancer due to obstructing malignant strictures are prone to underestimate t stage and cannot detect celiac adenopathy. eus staging in the setting of stenotic malignancies using the large caliber echoendoscope has been complicated by esophageal perforation. we report on the clinical utility of a newly developed, wire-guided echoendoscope for the complete staging of patients with esophageal cancer. | 1999 | 10385722 |
| carcinoma of the external auditory canal and middle ear. | to evaluate therapeutic modalities used at our institutions regarding local control, disease-free survival and actuarial survival in carcinoma of the external auditory canal and middle ear, in an attempt to provide guidelines for therapy. | 1999 | 10386634 |
| rectal cancer and inflammatory bowel disease: natural history and implications for radiation therapy. | there exists little information concerning the natural history of rectal cancer in patients with inflammatory bowel disease (ibd). in addition, the tolerance of pelvic irradiation in these patients is unknown. we analyzed the largest series of patients with ibd and rectal cancer in order to determine the natural history of the disease as well as the effect and tolerance of pelvic irradiation. | 1999 | 10386640 |
| long-term behavioral effects of repetitive pain in neonatal rat pups. | human preterm neonates are subjected to repetitive pain during neonatal intensive care. we hypothesized that exposure to repetitive neonatal pain may cause permanent or long-term changes because of the developmental plasticity of the immature brain. neonatal rat pups were stimulated one, two, or four times each day from p0 to p7 with either needle prick (noxious groups n1, n2, n4) or cotton tip rub (tactile groups t1, t2, t4). in groups n2, n4, t2, t4 stimuli were applied to separate paws at hou ... | 1999 | 10386907 |
| sliding clamp of the bacteriophage t4 polymerase has open and closed subunit interfaces in solution. | the sliding clamps of bacteriophage t4 (gp45), escherichia coli (beta clamp), and yeast (pcna) are required for processive dna synthesis by their cognate dna polymerases. the x-ray crystal structures of all three of these clamps have been shown to be closed, circular complexes. this paper reports investigations of the solution structure of bacteriophage t4 gp45 by analytical ultracentrifugation, fluorescence, and hydrodynamic modeling. mutants of gp45 with inter- and intrasubunit disulfide bonds ... | 1999 | 10387009 |
| side-chain and backbone flexibility in protein core design. | we have developed a computational approach for the design and prediction of hydrophobic cores that includes explicit backbone flexibility. the program consists of a two-stage combination of a genetic algorithm and monte carlo sampling using a torsional model of the protein. backbone structures are evaluated either by a canonical force-field or a constraining potential that emphasizes the preservation of local geometry. the utility of the method for protein design and engineering is explored by d ... | 1999 | 10388574 |
| evaluation of a simplified staging system for prognosis of hepatocellular carcinoma. | the current tnm (tumor, nodes, metastases) staging system for human hepatocellular carcinoma (hcc) has been challenged since a new t staging system was proposed to correlate the staging group with patient outcome after curative liver resection. the new t staging system proposed t1 as no vascular invasion, small size (< or = 5 cm), and solitary tumor. t2 was defined as the presence of one of the following factors: size greater than 5 cm, vascular invasion, or multiple tumors; t3 as the presence o ... | 1999 | 10389368 |
| psychological, clinical and pathological effects of relaxation training and guided imagery during primary chemotherapy. | the diagnosis and treatment of breast cancer are stressful, and stress may be associated with a poorer response to chemotherapy. there is a need, therefore, to develop and evaluate interventions that might enhance quality of life and, possibly, improve treatment response. the effects of relaxation combined with guided imagery (visualizing host defences destroying tumour cells) on quality of life and response to primary chemotherapy, to date, have not been adequately evaluated. ninety-six women w ... | 1999 | 10390006 |
| cadmium induced thyroid dysfunction in chicken: hepatic type i iodothyronine 5'-monodeiodinase activity and role of lipid peroxidation. | administration of cadmium chloride (2.5 mg/kg body weight/day) to chickens daily for 15 days decreased serum triiodothyronine (t3) concentration (by 68.75%) without altering the levels of serum thyroxine (t4). hepatic 5'-monodeiodinase (5'd-i) and superoxide dismutase (sod) activities were also decreased (by 90.47% and 20.81% respectively) with a concomitant increase in lipid peroxidation (lpo, by 206.25%). administration of the antioxidant vitamin e (alpha-tocopherol, 5 mg/kg body weight on alt ... | 1999 | 10390054 |
| the use of nuclear morphometry for the prediction of survival in patients with advanced cancer of the larynx. | we examined retrospectively whether the quantitative morphometric analysis of nuclear shapes in patients with advanced cancer of the larynx could be used as a prognostic factor. in all, specimens were taken from 90 patients treated by surgery in the department of otolaryngology, jagiellonian university, cracow, poland, between 1987 and 1988. the follow-up period was no shorter than 5 years. in the group examined there were 59 patients with t3 tumors and 31 with t4 tumors. a neck dissection was p ... | 1999 | 10392302 |
| persistent efficacy of doramectin injectable against artificially induced infections with cooperia punctata and dictyocaulus viviparus in cattle. | three studies were conducted to evaluate the persistent efficacy of doramectin injectable solution against experimental challenges with infective larvae of cooperia punctata and dictyocaulus viviparus. in each study, four groups of ten randomly-assigned calves, negative for trichostrongyle-type eggs on fecal examination, were treated subcutaneously in the midline of the neck with saline (1 ml/50 kg) on day 0 or doramectin (200 microg/kg = 1 ml/50 kg) on day 0, 7, or 14. two additional calves fro ... | 1999 | 10392767 |
| assaying rna chaperone activity in vivo using a novel rna folding trap. | in the absence of proteins, rnas often misfold in vitro due to alternative base pairings which result from the molecule being trapped in inactive conformations. we identify an in vivo folding trap in the t4 phage td gene, caused by nine base pairs between a sequence element in the upstream exon of the td gene and another at the 3' end of the intron. during translation, the ribosome resolves this interaction; consequently the intron folds correctly and splicing occurs. the introduction of a stop ... | 1999 | 10393192 |
| results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands. | patients with adenoid cystic carcinoma (acc) of the salivary glands in the head and neck region have been reported to benefit from neutron radiotherapy according to significant clinical experience. a prospective clinical trial on the efficacy and treatment related morbidity of fast neutron radiotherapy was performed between 1986 and 1995 at the (d + t) 14 mev neutron generator in münster. | 1999 | 10394401 |
| conformal proton beam therapy of prostate cancer--update on the loma linda university medical center experience. | the ability to eradicate localized prostate cancer is dependent upon the radiation dose which can be delivered to the prostate. this dose is often limited by the tolerance of normal organs (rectum, bladder). conformal beam therapy takes advantage of the unique depth dose characteristics of heavy charged particles (the bragg peak) to escalate the radiation dose delivered to the prostate while minimizing treatment-related toxicity. | 1999 | 10394406 |
| evaluation of argyrophilic nucleolar organizer regions in tongue squamous cell carcinomas. | using a silver staining technique, argyrophilic nucleolar organizer regions (agnors) were studied on the biopsy specimens taken from 67 tongue squamous cell carcinomas (sccs), and the relations of the results of agnors to the clinicopathological findings, to the labelling indices of proliferating cell nuclear antigen (pcna li), and to the outcomes of the disease were investigated. the mean numbers of agnors per cell were 1.67 +/- 0.19 (n = 27) in the control squamous epithelia and 3.58 +/- 1.15 ... | 1999 | 10211313 |
| results of subtotal thyroidectomy for graves' disease. | the objective of this study was to find the factors responsible for hypothyroidism after subtotal thyroidectomy for graves' disease. two hundred five patients who were operated on from july 1989 to december 1997 were studied. the mean age of patients was 33.4+/-11.0 (mean +/- sd) years, and 175 (85.4%) were female. patients were prepared with an antithyroid drug and lugol's solution preoperatively. triiodothyronine (t3), thyroxine (t4), thyrotropin (tsh), thyrotropin-binding immunoglobulins (tbi ... | 1999 | 10211601 |
| variations of sex hormone-binding globulin in thyroid dysfunction. | with the aim of understanding the variations of the levels of sex hormone-binding globulin (shbg) in thyroid dysfunction, we studied the influence of factors that also modify shbg, such as menopausal status, age, and body mass index (bmi) in women with hypothyroidism and hyperthyroidism, both overt and subclinical. statistical analysis was performed by means of analysis of variance (anova), stepwise multiple regression, and partial correlation. the anova showed a significant statistical differen ... | 1999 | 10211604 |
| ovarian function suppression with a gnrh analogue: d-ser(but[t])[6]-arzgly[10]-lhrh (goserelin) in hormone dependent canine mammary cancer. | hormones and hormone level modifying substances have long been used to treat hormone-dependent tumours in humans. recently, attempts have been made to use hormone manipulation regimens for the treatment of these tumours in veterinary medicine. the aim of the present study was to evaluate the activity of the luteinizing hormone-releasing hormone (lhrh)-agonist, d-ser(but[t])[6]-azgly[10]-lhrh (goserelin) in hormone-dependent mammary cancer in dogs. eighteen female dogs with hormone-dependent mamm ... | 1999 | 10211718 |
| computational studies on mutant protein stability: the correlation between surface thermal expansion and protein stability. | thermal stability of mutant proteins has been investigated using temperature dependent molecular dynamics (md) simulations in vacuo. the numerical modeling was aimed at mimicking protein expansion upon heating. after the conditions for an expanding protein accessible surface area were established for t4 lysozyme and barnase wild-type proteins, md simulations were carried out under the same conditions using the crystal structures of several mutant proteins. the computed thermal expansion of the a ... | 1999 | 10211838 |
| expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. | thyroid hormone is an important epigenetic factor in brain development, acting by modulating rates of gene expression. the active form of thyroid hormone, 3,5,3'-triiodothyronine (t3) is produced in part by the thyroid gland but also after 5'-deiodination of thyroxine (t4) in target tissues. in brain, approximately 80% of t3 is formed locally from t4 through the activity of the 5'-deiodinase type 2 (d2), an enzyme that is expressed mostly by glial cells, tanycytes in the third ventricle, and ast ... | 1999 | 10212303 |
| [preoperative balloon occluded arterial infusion chemotherapy for locally invasive bladder cancer--accurate staging for bladder preservation]. | the possibility of bladder preservation by preoperative balloon occluded arterial infusion (boai) chemotherapy was studied in 111 patients with locally invasive bladder cancer. boai was performed by blocking the blood flow of the internal iliac artery and by performing intra-arterial infusion of adriamycin (50 mg/body) and cisplatin (100 mg/body). before boai the clinical diagnosis was t2 in 36, t3a in 29, t3b in 27, t4 in 11 and after boai it was t0 in 1, t1 in 27, t2 in 25, t3a in 20, t3b in 2 ... | 1999 | 10212789 |
| [intra-arterial chemotherapy for locally advanced bladder cancer]. | a total of 83 patients with locally advanced bladder cancer (t1, n = 5; t2, n = 28; t3a, n = 21; t3b, n = 21; t4, n = 8) were treated with intra-arterial (i.a.) cisplatin and adriamycin (or epirubicin) chemotherapy. in 51 of the 83 cases, we combined this treatment with radiotherapy. the pathological complete response (cr) rate was 68% for all patients, 84% for i.a. chemotherapy combined with radiotherapy and only 41% for i.a. chemotherapy. the 5-year survival rate was 57% for all patients, 71% ... | 1999 | 10212791 |
| dna helicases displace streptavidin from biotin-labeled oligonucleotides. | helicases are enzymes that use energy derived from nucleoside triphosphate hydrolysis to unwind double-stranded (ds) dna, a process vital to virtually every phase of dna metabolism. the helicases used in this study, gp41 and dda, are from the bacteriophage t4, an excellent system for studying enzymes that process dna. gp41 is the replicative helicase and has been shown to form a hexamer in the presence of atp. in this study, protein cross-linking was performed in the presence of either linear or ... | 1999 | 10213622 |
| effect of cold exposure on thyroid hormone metabolism and nuclear binding in rat brain. | in this study we examined whether adult rat brain tissue (cerebral hemispheres) would under cold exposure respond with changes in the local metabolism and nuclear binding of thyroid hormones (t3, t4). adult, control rats kept at 22 degrees c and cold exposed (4 degrees c, 20 h) rats were injected with trace of 125i-t4 or 125i-t3 returned to their respective environment and sacrificed four hours later. the radioactive hormonal forms were identified and quantified in the cytoplasmic and nuclear fr ... | 1999 | 10215517 |
| t4 rna ligase catalyzes the synthesis of dinucleoside polyphosphates. | t4 rna ligase has been shown to synthesize nucleoside and dinucleoside 5'-polyphosphates by displacement of the amp from the e-amp complex with polyphosphates and nucleoside diphosphates and triphosphates. displacement of the amp by tripolyphosphate (p3) was concentration dependent, as measured by sds/page. when the enzyme was incubated in the presence of 0.02 mm [alpha-32p] atp, synthesis of labeled ap4a was observed: atp was acting as both donor (km, microm) and acceptor (km, mm) of amp from t ... | 1999 | 10215898 |
| crystallization and preliminary x-ray crystallographic analysis of deoxycytidylate hydroxymethylase from bacteriophage t4. | deoxycytidylate hydroxymethylase from bacteriophage t4 is a homodimeric enzyme in which each polypeptide chain consists of 246 amino-acid residues. it has been crystallized in the presence of its substrate, deoxycytidine monophosphate, at room temperature using sodium citrate as precipitant. the crystals are monoclinic, belonging to space group c2, with unit-cell parameters a = 174.22, b = 53.12, c = 75.17 a, beta = 115.29 degrees. the asymmetric unit contains one homodimer, with a corresponding ... | 1999 | 10216306 |
| interaction of amiodarone and triiodothyronine on the expression of beta-adrenoceptors in brown adipose tissue of rat. | 1. this study was undertaken to evaluate in vivo the influence of amiodarone on the effects of triiodothyronine (t3) in brown adipose tissue (bat) which are independent of thyroid hormone synthesis and of the conversion of thyroxine (t4) to t3. thyroidectomized rats were given a replacement dose of t3 (0.5 mg kg(-1) p.o. daily for 3 days) with or without amiodarone (50 mg kg(-1) p.o. daily for 1 week). 2. as assessed by rt-pcr, treatment of thyroidectomized rats with t3 caused a 2 fold decrease ... | 1999 | 10217540 |
| the c-terminal fragment of the precursor tail lysozyme of bacteriophage t4 stays as a structural component of the baseplate after cleavage. | tail-associated lysozyme of bacteriophage t4 (tail lysozyme), the product of gene 5 (gp 5), is an essential structural component of the hub of the phage baseplate. it is synthesized as a 63-kda precursor, which later cleaves to form mature gp 5 with a molecular weight of 43,000. to elucidate the role of the c-terminal region of the precursor protein, gene 5 was cloned and overexpressed and the product was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunoblotting, anal ... | 1999 | 10217762 |
| long-term growth after hypophyseal stalk transection and hypophysectomy of beef calves. | hypothalamic hormones regulate episodic and basal secretion of hormones from the anterior pituitary gland that affect metabolism and growth in cattle. this study focused on long-term growth in young calves subjected to hypophysectomy (hypox), hypophyseal stalk transection (hst), and sham operation control (soc). cross-bred (hereford x aberdeen angus) and hereford, and aberdeen angus calves were hypox (n = 5), hst (n = 5), or soc (n = 8) at 146 +/- 2 days of age, whereas another group was hst (n ... | 1999 | 10218995 |
| identification of transthyretin in fish (sparus aurata): cdna cloning and characterisation. | transthyretin (ttr) has been proposed to have first evolved in reptiles and is one of the three plasma proteins important in the transport of thyroid hormones in higher vertebrates. a full-length cdna encoding ttr was isolated from a sea bream (sparus aurata) liver cdna library using a homologous ttr cdna probe generated by rt-pcr. comparison of the deduced amino acid sequence of sea bream ttr with other published sequences, revealed an overall identity of 47-54%, although the amino acids in the ... | 1999 | 10218999 |
| are thyroid function tests too frequently and inappropriately requested? | in spite of data supporting the use of the serum thyrotropin (tsh) concentration as the best test to detect abnormal thyroid function, measurement of circulating thyroid hormones with or without a serum tsh continues to be frequently requested to evaluate thyroid function. we have analyzed how combinations of thyroid function tests were ordered by referring physicians and the results of the tests in order to offer some suggestions as to how to use thyroid function tests in a cost effective manne ... | 1999 | 10219885 |
| changes in thyroid gland morphology after acute acrylamide exposure. | high exposure to the acrylamide monomer has been associated with neuropathy and neurotoxic effects. chronic lower exposure causes endocrine disruption associated with thyroid, testicular, and mammary tumors. to investigate mechanisms of endocrine disruption, short-term, low-level oral dosing studies were conducted. weanling female fischer 344 rats were acclimatized for two weeks before dosing. controls were given distilled water by gavage and rats in other groups were given acrylamide at doses o ... | 1999 | 10220851 |
| effects of acute exposure to pcbs 126 and 153 on anterior pituitary and thyroid hormones and fsh isoforms in adult sprague dawley male rats. | 3,3'4,4',5-pentachlorobiphenyl (pcb 126) and 2,2',4,4',5,5'-hexachlorobiphenyl (pcb 153) were administered to adult male rats in order to identify sensitive indicators of endocrine disruption. we tested the hypothesis that pcb exposure modifies follicle-stimulating hormone (fsh) pituitary isoforms, as well as the pituitary and serum concentrations of fsh, luteinizing hormone (lh), growth hormone, prolactin, and thyroid-stimulating hormone (tsh). effects on serum levels of thyroxine (t4) and test ... | 1999 | 10220852 |
| inhibition of thyroid iodine uptake and organification in rats treated with kojic acid. | in order to elucidate the mechanisms of reduction of serum thyroid hormones caused by continuous administration of kojic acid (ka) and its thyroid tumor-promotion effects, male f344 rats were given pulverized basal diet containing 0.008%, 0.03%, 0.125%, 0.5%, or 2% ka for 4 weeks. as an untreated control group, additional rats were given basal diet alone for the same period. the thyroid 125i uptake was significantly decreased in the groups receiving 0.03% or more. in addition, significant reduct ... | 1999 | 10220853 |
| clonal differences among erythromycin-resistant streptococcus pyogenes in spain. | the aim of this study was to determine whether the high levels of erythromycin resistance in streptococcus pyogenes found in spain are due to the introduction and spread of one or more clones. phenotypic and genotypic techniques were used to characterize all erythromycin-resistant s. pyogenes (err) isolated in gipuzkoa, spain, in the last 10 years and 128 err isolated in vitoria and madrid during 1996. of 437 err, 97% had the m phenotype; all 283 of the strains studied had the mefa determinant o ... | 1999 | 10221875 |
| biochemical hypothyroidism secondary to iodine deficiency is associated with poor school achievement and cognition in bangladeshi children. | iodine deficiency in pregnancy leads to poor cognitive function in the offspring; however, the effect of concurrent iodine deficiency on school-aged children is not clear. several studies have shown that school children in iodine-deficient villages have poorer cognitive function than children in iodine-sufficient villages. however, villages differ in many factors that may also detrimentally affect children's development. in addition, the children's nutritional and health status has not usually b ... | 1999 | 10222389 |
| human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract. | some studies have shown that human papillomavirus (hpv) infection may play not only an etiologic role in anogenital cancers but also a role in the clinical outcome. the objective of the current study was to determine whether detection of hpv dna in primary squamous cell carcinomas of the upper aerodigestive tract (uadt) is a prognostic factor in patients with the disease. | 1999 | 10223228 |
| total skin electron radiation for patients with erythrodermic cutaneous t-cell lymphoma (mycosis fungoides and the sézary syndrome). | there is limited published evidence regarding the efficacy of total skin electron beam radiation for patients with the diffuse erythrodermic form of mycosis fungoides. | 1999 | 10223240 |
| malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes. | cancers of the anal canal are a rare and diverse group of tumors of the gastrointestinal tract currently managed most often with surgery, chemoradiotherapy, or both. previous investigations of cancer of the anal canal have reported on small numbers of patients, included only squamous histology, or included a select group of patients. the current study reviewed a large consecutive series of patients with cancer of the anal canal, including all histologies, who received chemoradiotherapy as the pr ... | 1999 | 10223561 |
| low risk of locoregional recurrence of primary breast carcinoma after treatment with a modification of the halsted radical mastectomy and selective use of radiotherapy. | the purpose of the current study was to evaluate the locoregional recurrence rate after treatment of patients with operable breast carcinoma with a modification of the halsted radical mastectomy and the selective use of radiotherapy and to identify risk factors for locoregional recurrence. | 1999 | 10223572 |
| on the structure of the scaffolding core of bacteriophage t4. | the scaffolding core in bacteriophages is a temporary structure that plays a major role in determining the shape of the protein shell that encapsulates the viral dna. in the currently accepted structure for the scaffolding core in bacteriophage t4, there is a symmetry mismatch between the protein shell, which has fivefold symmetry, and the scaffolding core, which is believed to consist of six helical chains. the analysis of t4 giant prohead data that was used to determine this structure made an ... | 1999 | 10223661 |
| role of pleural lavage cytology before resection for primary lung carcinoma. | to investigate the role of pleural lavage cytology (plc) in resection for primary lung carcinoma. | 1999 | 10203093 |
| prognostic value of p27kip1 and p21waf/cip protein expression in muscle invasive bladder cancer. | two genes, namely p27kip1 and p21waf/cip1 that reveal distinct structural homology, have been identified as inductors of cell cycle arrest at the g1-checkpoint to prevent entry of somatic cells into the s phase of the cell cycle when substantial dna damage has occurred. it was demonstrated that the p21waf/cip1 gene is induced by pathways dependent and independent from a functionally intact p53 tumour suppressor protein. it has been suggested that decreased expression both of the p21waf/cip1 and ... | 1999 | 10203616 |
| thyroid function and energy intake during weight gain following treatment of hyperthyroidism. | individuals with hyperthyroidism lose weight despite increased appetite and food intake, and weight is regained after treatment of hyperthyroidism. we asked whether this weight regain is purely a function of lowered metabolic rate coincident with lowered thyroid hormone concentrations or if the weight gain is related to food-energy overconsumption. | 1999 | 10204837 |
| elevations of serum t3 levels and their association with symptoms in world war ii veterans with combat-related posttraumatic stress disorder: replication of findings in vietnam combat veterans. | in previous serum thyroid studies, we reported an unusual thyroid profile, including elevated levels of total and free triiodothyronine (t3), total thyroxine (t4), and thyroxine-binding globulin (tbg) with no elevations in free t4 and thyrotropin (tsh) in vietnam veterans with combat-related posttraumatic stress disorder (ptsd) compared to control subjects. in a subsample of vietnam veterans, we found a significant positive correlation between total t3, free t3, and ptsd symptoms, specifically h ... | 1999 | 10204962 |
| comparison of mechanisms mediating uptake and efflux of thyroid hormones in the human choriocarcinoma cell line, jar. | we compared the specificities of transport mechanisms for uptake and efflux of thyroid hormones in cells of the human choriocarcinoma cell line, jar, to determine whether triiodothyronine (t3), thyroxine (t4) and reverse t3 (rt3) are carried by the same transport mechanism. uptake of 125i-t3, 125i-t4 and 125i-rt3 was saturable and stereospecific, but not specific for t3, t4 and rt3, as unlabelled l-stereoisomers of the thyroid hormones inhibited uptake of each of the radiolabelled hormones. effl ... | 1999 | 10194534 |
| acute pretranslational regulation of type iii iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos. | both growth hormone (gh) and glucocorticoids are regulators of thyroid hormone metabolism in vertebrates. studies on chicken embryos demonstrated that intravenous (i.v.) injection of chicken gh or glucocorticoids results in increased plasma 3,3',5-triiodothyronine (t3) concentrations, and this through a reduction of hepatic type iii iodothyronine deiodinase (d3) activity. the recent cloning of chicken type i iodothyronine deiodinase (d1) and d3 offers the tools to investigate at what level (pre- ... | 1999 | 10195691 |
| assessment of serum thyroxine binding capacity-dependent biases in free thyroxine assays. | free thyroxine (ft4) assays may exhibit biases that are related to serum t4 binding capacity (sbc). we describe two tests that can be used to assess the presence and magnitude of sbc-dependent biases in ft4 assays. | 1999 | 10102912 |
| identification of true differentially expressed mrnas in a pair of human bladder transitional cell carcinomas using an improved differential display procedure. | differential display in combination with arbitrarily primed polymerase chain reaction (pcr) fingerprinting has become one of the most powerful techniques to identify and isolate mrnas that are differentially expressed in pairs of biological samples. however, in many cases the cdna band corresponding to the differentially amplified product contains several cdna species that comigrate with the cdna of interest due to the poor resolution of the fingerprinting gels, thus hampering further analysis a ... | 1999 | 10197429 |
| t4 lung tumors with infiltration of the thoracic aorta: is an operation reasonable? | only anecdotal reports about the results of combined resection of t4 lung tumors infiltrating the thoracic aorta exist. | 1999 | 10197651 |
| long-term outcome after postmastectomy radiation therapy for breast cancer patients at high risk for local-regional recurrence. | postmastectomy radiation therapy is often recommended for patients at high risk for local-regional recurrence after mastectomy. however, long-term outcomes after radiation therapy are not well described. | 1999 | 10198729 |
| success rate of radioiodine therapy in graves' disease: the influence of thyrostatic medication. | there is controversy whether simultaneous thyrostatic medication influences the outcome of radioiodine (131i) therapy in graves' disease by reducing the absorbed energy dose of 131i when delivering a standard dose. we therefore sought to ascertain whether the outcome of ablative 131i therapy is in any way affected by simultaneous thyrostasis (carbimazole) by aiming for a constant absorbed dose of 200-250 gy. we prospectively studied 207 patients with graves' disease (106 with and 101 without sim ... | 1999 | 10199759 |
| characterization of human iodothyronine sulfotransferases. | sulfation is an important pathway of thyroid hormone metabolism that facilitates the degradation of the hormone by the type i iodothyronine deiodinase, but little is known about which human sulfotransferase isoenzymes are involved. we have investigated the sulfation of the prohormone t4, the active hormone t3, and the metabolites rt3 and 3,3'-diiodothyronine (3,3'-t2) by human liver and kidney cytosol as well as by recombinant human sult1a1 and sult1a3, previously known as phenol-preferring and ... | 1999 | 10199779 |
| effects of thyroid hormones on apoptotic cell death of human lymphocytes. | apoptosis plays a critical role in the development and homeostasis of tissues, especially those with high cell turnover such as the lymphoid system. we have examined the effects of thyroid hormones, tsh and trh, on apoptosis of human t lymphocytes. we found that t lymphocytes cultured with t3 and t4, but not tsh nor trh, in vitro showed enhanced apoptosis, evidenced by dna ladder formation and characteristic morphological changes. in addition, prolonged cultivation with thyroid hormones of the l ... | 1999 | 10199782 |
| processing of uv damage in vitro by fen-1 proteins as part of an alternative dna excision repair pathway. | ultraviolet (uv) irradiation induces predominantly cyclobutane and (6-4) pyrimidine dimer photoproducts in dna. several mechanisms for repairing these mutagenic uv-induced dna lesions have been identified. nucleotide excision repair is a major pathway, but mechanisms involving photolyases and dna glycosylases have also been characterized. recently, a novel uv damage endonuclease (uvde) was identified that initiates an excision repair pathway different from previously established repair mechanism ... | 1999 | 10200169 |
| effect of thyroid hormone on concentrations of plasma calcitonin in broiler chicks. | the purpose of these studies was to determine the effect of thyroidectomy (tx), and thyroid hormone (t3/t4) treatment on concentrations of plasma ct in chicks. in addition, the turnover of ct in tx- and t3/t4-treated chicks was estimated using a novel nonradioactive salmon ct preparation. one-week-old broiler chicks (gallus domesticus) (n = 75) were divided into three groups. group i was sham-injected daily (i.m. saline), group ii was injected with 50 micrograms/day of t3/t4 while group iii was ... | 1999 | 10190028 |
| a mechanistic approach to modeling single protein adsorption at solid-water interfaces. | a kinetic model for single component protein adsorption which can be readily extended to adsorption from multi-protein solutions was developed, and used to simulate adsorption of site-directed, structural stability mutants of bacteriophage t4 lysozyme. the model allows for two different adsorbed "states," distinguished by different binding strengths and different occupied areas. the presence of an increasing energy barrier to adsorption was incorporated into the model by formulating the adsorpti ... | 1999 | 10191030 |
| [prognostic significance of egfr and p53 expression, and angiogenesis in laryngeal squamous cell carcinoma]. | to estimate the influence of egfr, p53, and angiogenesis to the survival of laryngeal cancer patients. | 1999 | 10191626 |
| efficient synthesis of dna dumbbells using template-induced chemical ligation in double-stranded polynucleotides closed by minihairpin fragments. | the chemical ligation of 17 50-54-membered nicked dna dumbbells with different closing fragments, nick positions, and nucleotides facing the nick were investigated. t4, t5, gta4c, gcga2gc, and gcga3gc sequences were chosen as the closing fragments. the nicks were placed in the center of the duplex stem or were adjacent to the closing fragments. n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide and cyanogen bromide were used as the condensing agents. we showed that the ligation efficiency is 10%-90% ... | 1999 | 10192294 |
| the accuracy of transrectal ultrasound in predicting the pathological stage of low-lying rectal cancer after preoperative chemoradiation therapy. | there has been a growing interest in the use of preoperative radiation therapy in rectal cancer treatment in the last years. the need for accurate preoperative staging is important so as to avoid overtreatment in stage i patients, and to select patients who require downstaging prior to surgery as they are technically inoperable. while transrectal ultrasound (trus) has been reported to accurately stage preoperative patients, its efficacy postradiation has been questioned. the authors report a ser ... | 1999 | 10192353 |
| involvement of the #12u lymph nodes around the upper lobe bronchi in patients with lung cancer of the right middle lobe, right lower lobe, or left lower lobe. | in japan, the lymph nodes around the upper lobe bronchi, known as the #12u nodes, are not included in the nodes recommended for dissection in patients with right middle lobe carcinoma, right lower lobe carcinoma, or left lower lobe carcinoma. however, histologic examination has revealed involvement of these nodes in pneumonectomy patients whose carcinoma originated in the right lower lobe. we histologically examined the lymph nodes from 152 patients with lung cancer to determine the incidence of ... | 1999 | 10192734 |