Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| igf-1 and igfbp in congenital and acquired hypothyroidism after long-term replacement treatment. | thyroid hormones are involved in the regulation of the gh/igf axis. hypothyroidism is associated with a reduction in gh pulsatility and in gh-response to stimulatory tests. in hypothyroidism, serum levels of igf-1 and igfbp-3 fall and these changes are reversed after short term replacement with l-t4. this study was undertaken to determine the effect of long term replacement therapy with t4 in igf-1 and igfbp-3 serum levels. | 1999 | 10941423 |
| dietary protein effects on the broiler's adaptation to triiodothyronine. | the purpose of this experiment was to study the effects of dietary protein on metabolic adaptations in birds given triiodothyronine (t3) at 28 d of age. knowledge about the role of dietary protein in thyroid metabolism is lacking. male broiler chickens were fed diets containing either 120 or 300 g crude protein/kg from 7 to 28 d. at this time, one-half of each group was given that diet supplemented with 1 mg/kg t3. birds were sampled at 0, 2, 5, 7, 9 and 12 d following the initiation of the t3 t ... | 1999 | 10921501 |
| treatment of hypopituitarism in infancy. effect on head circumference growth. | head circumference of children with multiple pituitary-hormone deficiency (mphd) may be subnormal for age. moreover it is known that linear growth in infancy is growth-hormone (gh) dependent. therefore, aim of the study has been to compare head circumference measurements in children with hypopituitarism after l-thyroxine (l-t4) therapy alone, before therapy with gh, and after gh was added to the therapy. | 1999 | 10953724 |
| sub-biochemical hypothyroidism: an exaggerated thyroid stimulating hormone response to thyrotrophin releasing hormone. | the availability of sensitive and specific assays for evaluation of the thyroid axis has allowed definition of thyroid disorders at subclinical stage. this has almost obviated the use of thyrothrophin releasing hormone (trh) study. we describe here a group of patients with minimal signs of hypothyroidism having normal thyroid function tests (t3, t4, thyroid stimulating hormone (tsh)) and have shown exaggerated tsh response to trh. | 1999 | 10999119 |
| thyroid function in the sick very low-birth-weight infants. | this study was undertaken to determine postnatal changes in thyroid function in very low-birth-weight (vlbw) infants. a total of one-hundred vlbw infants participated. serial examination of serum levels of thyroxine (t4), free t4, triiodothyronine (t3), and thyroid-stimulating hormone (tsh) was performed in the neonatal period. a total of eighty-nine infants survived to discharge, while eleven died during hospitalization. transient hypothyroxinemia was found in forty-one (46.1 percent) of the su ... | 1999 | 10910620 |
| longitudinal study of serum free thyroxine and thyrotropin levels by chemiluminescent immunoassay during infancy. | from october 1996 to december 1997, ninety normal infants born at full-term were enrolled in this study. there were 59 female infants and 31 male infants. both serum free thyroxine and thyrotropin levels were measured by chemiluminescent immunoassay in the first week (n = 75), 3 months (n = 66), 6 months (n = 79), and 12 months (n = 77) of age. serum free thyroxine levels (ng/dl) (mean +/- standard deviation) were 2.2 +/- 0.5, 1.3 +/- 0.2, 1.2 +/- 0.2, 1.0 +/- 0.2 for each age group, respectivel ... | 1999 | 10910623 |
| thyroid function in thalassaemia major. | short stature is common in thalassaemia major. hypothyroidism resulting from haemosiderosis has been implicated, but this complication has not been investigated in sri lanka. | 1999 | 10895267 |
| three-dimensional imaging of the speaking shunt in patients with near-total laryngectomy. | near-total laryngectomy with creation of a speaking shunt is generally considered suitable treatment for most t3 and some t4 laryngopharyngeal cancers. in some patients, poor speech production by the shunt can be problematic and usually means that a shunt lumen is stenotic or too small. conventional axial computed tomography (ct) of the neck is of little value in predicting the shunt function and the patency of the shunt lumen. such defect, however, can be better overcome if the spiral ct is use ... | 1999 | 10890771 |
| carcinoma of the male breast: a review of adjuvant therapy. | the purpose of the present paper was to evaluate the characteristics and outcomes of male breast cancer patients seen for adjuvant therapy at a single institution. a retrospective review of computerized records in the departments of medical and radiation oncology at the royal prince alfred hospital (rpah) was undertaken. between 1983 and 1996, 24 men were referred for treatment of breast cancer. of these, 19 had localized breast cancer, four had metastatic disease and one had ductal carcinoma in ... | 1999 | 10901873 |
| pre-operative chemo-radiotherapy in locally advanced rectal cancer: is this the way of future management? | the purpose of the present paper was to update a prospective analysis (h elsaleh et al. unpubl. data, 1997) investigating the effectiveness and toxicity of pre-operative pelvic radiotherapy with modest dose 5-fluorouracil (5-fu) in locally advanced rectal cancer (t3-t4). a total of 31 patients were assessed (28 t3 and three t4 tumours). pre-operative pelvic radiotherapy was delivered in four fields, 45 gy to the international commission on radiation units and measurements (icru) point in 25 frac ... | 1999 | 10901905 |
| measurement of free thyroxine (t4) levels in pregnancy. | free t4 and tsh were measured in 119 pregnant women. twenty of these women had the free t4 measured a second time during the pregnancy; 35 of the 119 had the free t4 measured by 2 different methods. the results showed that free t4 fell as pregnancy progressed but even at the early stages of pregnancy many measured free t4 concentrations were below the lower end of the nonpregnant normal range. this remained the case when the measurement was made by a dialysis kit method. these results challenge ... | 1999 | 10755769 |
| information needs and preference for information of women with breast cancer over a first course of radiation therapy. | the study assessed the information needs of women receiving a course of radiation therapy (rt) for breast cancer and the relationship between information needs and preference for information. thirty-three women were interviewed during the first (t1), third (t2), and last week of rt (t3), and one month later (t4) using the toronto informational needs questionnaire--breast cancer and the information subscale of the health opinion survey. information need scores were high and did not differ signifi ... | 1999 | 10865687 |
| diagnostic delays in head and neck cancers. | head and neck cancers are a significant and worsening health problem in the uk. in the absence of screening, minimising diagnostic delay after the onset of symptoms improves prognosis. delay, from the patient's initial experience of symptoms to the ultimate diagnosis, consists of two elements--the delay prior to presenting to a clinician plus that due to the health professional consulted. this study aimed to establish the period of delay between recognition of the initial tumour symptoms and the ... | 1999 | 10889616 |
| solid-phase enzymatic synthesis of oligonucleotides. | [formula: see text] the controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme t4 rna ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide. | 1999 | 10836032 |
| left thoracoscopic sympathectomy and stellate ganglionectomy for treatment of the long qt syndrome. | the long qt syndrome (lqts) is a rare inherited cardiac disorder that may induce fatal cardiac arrhythmias. patients diagnosed with this disorder generally have several treatment options, including beta-blockade, cardiac pacing, an implantable automatic defibrillator, or a high thoracic left sympathectomy. we report the case of a 6-year-old girl with the lqts treated by left thoracoscopic sympathectomy and stellate ganglionectomy. the procedure was performed after an initial thorascopic attempt ... | 1999 | 10854513 |
| rbe-let relationships in mutagenesis by ionizing radiation. | the paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. the paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and drosophila melanogaster. experimental data are presented for the relative biological effectiveness of helium ions and alpha-particles for mutation induction and genome lethality in escherichia coli. the paper examines the relationshi ... | 1999 | 10804998 |
| therapeutic efficacy of flavonoids in oedema following reperfusion on acutely ischaemic legs. | the aim of this study was to investigate the effect of a purified, micronised, flavonoid fraction (daflon) in lower limb oedema developed after delayed embolectomy and successful reperfusion of acutely ischaemic legs. | 1999 | 10811522 |
| stretching (?) of the spinal cord as a cause of paraplegia in a patient with cushing's syndrome. | paraplegia with a total anesthesia level was found in a patient who had cushing's syndrome. there was marked osteoporosis of the spine and a moderate wedge shaped compression fracture of the t4 vertebral body but no stenosis of the canal could be observed. on the grounds of the ct findings stretching of the spinal cord caused by the rapidly evolving kyphosis of the thoracic tract has been thought to be the responsible factor of the clinical deficits. | 1999 | 10817388 |
| use of differentially substituted selenomethionine proteins in x-ray structure determination. | using heavily methionine-substituted t4 lysozyme as an example, it is shown how the addition or deletion of a small number of methionines can simplify the location of selenium sites for use in mad phasing. by comparing the x-ray data for a large number of singly substituted lysozymes, it is shown that the optimal amino acid to be substituted by methionine is leucine, followed, in order of preference, by phenylalanine, isoleucine and valine. the identification of leucine as the first choice agree ... | 1999 | 10666571 |
| effects of intraoperative glucose administration on circulating metabolites and nitrogen balance during prolonged surgery. | to compare the effects of intraoperative administration of 2.5% glucose or ringer's solution on metabolism during prolonged surgery. | 1999 | 10680106 |
| [changes in the lipid profile and thyroid function in adult patients with hypopituitarism after substitutive treatment with growth hormone]. | adult growth hormone (gh) deficiency is associated with changes in serum lipid levels that can modify after gh substitution. | 1999 | 10680141 |
| antagonism of rapacuronium using edrophonium or neostigmine: pharmacodynamics and pharmacokinetics. | we have studied the pharmacodynamics and pharmacokinetics of rapacuronium (org 9487) in 70 healthy patients. neuromuscular transmission was monitored using tof stimulation of the ulnar nerve and mechanomyography of the adductor pollicis muscle. half of the patients were given a single dose of rapacuronium 1.5 mg kg-1 and the remainder rapacuronium 1.5 mg kg-1 with three incremental doses of 0.5 mg kg-1, each given when t1/t0 had recovered to 25%. in all patients, neuromuscular block was antagoni ... | 1999 | 10690134 |
| [reference values for thyroid hormones, thyrotropin and thyroglobulin in healthy children of zaragoza]. | the purpose of this study was to estimate the basal serum concentration reference values for total t3 (t3), total t4 (t4), free t4 (ft4), thyrotropin (tsh) and thyroglobulin (tg) in healthy children of zaragoza. | 1999 | 10690228 |
| effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol. | the present study was designed to examine the effects of chronic amiodarone on the different ventricular cell subtypes in situ and to evaluate its interactions with sotalol. | 1999 | 10690307 |
| messenger rna stability and its role in control of gene expression in bacteria and phages. | the stability of mrna in prokaryotes depends on multiple factors and it has not yet been possible to describe the process of mrna degradation in terms of a unique pathway. however, important advances have been made in the past 10 years with the characterization of the cis-acting rna elements and the trans-acting cellular proteins that control mrna decay. the trans-acting proteins are mainly four nucleases, two endo- (rnase e and rnase iii) and two exonucleases (pnpase and rnase ii), and poly(a) ... | 1999 | 10690408 |
| a comparison study of two therapeutic protocols for neurosyphilis. | in morocco, neurosyphilis is a serious public health problem. in the neurology service at the specialist hospital in rabat, two drug treatments were used. treatment a consisted of infusion over a period of 4 h of 20 mui of penicillin g per day for 3 weeks. treatment b consisted of infusion over a period of 6 h of 30 mui of penicillin g per day for 10 days. each treatment was tested on a group of eight neurosyphilitic patients as first-line treatment. on the first day of treatment, both blood and ... | 1999 | 10667099 |
| [preoperative radiotherapy of rectal cancer. the lyons experience, 1985-1996. prognostic study apropos of 312 patients]. | preoperative radiotherapy is used increasingly in rectal cancer in europe. this study is a retrospective analysis of a series of 312 patients with rectal adenocarcinoma treated by preoperative radiotherapy. | 1999 | 10670149 |
| a fe(3+)/dna complex induces an anti-human immunodeficiency virus factor(s) in cd4+ lymphocyte cell lines. | numerous cytokines and chemokines are involved in inflammatory and immune response. whereas some of them inhibit virus replication in vitro directly or increase the patients' t4-lymphocyte level, others effects are not so clear. using human immunodeficiency virus (hiv) and cell cultures we have studied the antiviral effect of complexes of salmon dna with metals and of a new factor(s) (antiviral factor, avf) induced in cells by the complexes. the fe3+/dna complex possessed the highest antiviral a ... | 1999 | 10672340 |
| [trans-sternal approach to the cervicothoracic junction]. | cervicothoracic junction and upper thoracic spine down to t4 can be reached through anterior approach via sternotomy. transsternal approach is the best route to gain access to lesions localized within vertebral bodies of the upper thoracic spine allowing for their resection, interbody fusion and replacement with bone cement. consecutive modifications of transsternal approach evolved toward less extensive osteotomy from full median sternotomy, through manubriotomy with clavicle resection and part ... | 1999 | 10672570 |
| the stem hairpin loop structure of p2sp1 rna is required for rna-cleaving activity. | we studied the hairpin-loop structure of an rna fragment (guuucguacaaac) (r13) with the sequence corresponding to the self-cleavage domain in the precursor of an rna molecule from bacteriophage t4-infected escherichia coli cells (p2sp1 rna). in order to determine the influence of the hairpin-loop structure on these sequence-specific cleavage reactions, we have synthesized oligoribonucleotides containing hairpin-loop, double-helical stem-loop, and single-stranded rna structures. the cleavage was ... | 1999 | 10673038 |
| measurement imprecision in vertebral morphometry of spinal radiographs obtained in the european prospective osteoporosis study: consequences for the identification of prevalent and incident deformities. | several algorithms are currently in use for evaluating vertebral deformities from plain lateral radiographs of the lumbar and thoracic spine. however, the effects of measurement imprecision as well as uncertainties over image magnification on the correct identification of prevalent and incident vertebral deformities with these algorithms has been little studied. in a pilot study for the european prospective osteoporosis study (epos), plain radiographs were submitted to a single central evaluatin ... | 1999 | 10673947 |
| psychological factors can predict the response to primary chemotherapy in patients with locally advanced breast cancer. | this study evaluated the possible value of psychological variables in predicting clinical and pathological response to primary chemotherapy. 96 women with newly diagnosed large, or locally advanced, breast cancer (t2 > 4 cm, t3, t4, n2 and m0) participated in a prospective, randomised trial to evaluate the effects of relaxation training with guided imagery and l-arginine on response to primary chemotherapy. before the first of six cycles of primary chemotherapy, women were assessed using the hos ... | 1999 | 10673992 |
| [thyroid hormone resistance syndromes: clinical aspects]. | introduction: syndromes of resistance to thyroid hormone correspond to variable clinical states which are usually transmitted as autosomal dominant traits and characterized by the lack of sensitivity of target tissues to triiodothyronine (t3). the diagnosis has to be performed in order to offer an appropriate therapy. current knowledge and key points: clinical states range between two extremes: the generalized form, with global euthyroidism, and the predominantly pituitary form, with thyrotoxico ... | 1999 | 10635073 |
| conservation surgery for laryngeal and hypopharyngeal cancer. | the charts of 173 patients treated by conservation laryngectomy and pharyngolaryngectomy were retrospectively reviewed. the patients treated by endoscopic laser resection were excluded of this study. glottic carcinoma was diagnosed in 101 patients, supraglottic carcinoma in 44 patients, hypopharyngeal carcinoma in 24 patients and oropharyngeal carcinoma in 4 patients. the median follow-up period was 44 months, 84/101 glottic cancer, 34/44 supraglottic cancer, 23/24 hypopharyngeal cancer and 2/4 ... | 1999 | 10635394 |
| [simultaneous presentation of actinomycosis and metastatic pharyngeal carcinoma]. | although actinomycosis frequently presents as a pseudotumoral syndrome, the simultaneous diagnosis of actinomycosis and cancer is exceptional. actinomycosis can occur as an opportunistic infection secondary to the antineoplastic treatment and even the cancer itself can act as facilitating factor. we report a patient who was diagnosed simultaneously of advanced oropharinx cancer (t4-n1-m0) and actinomycosis associated to the tumoral mass. this exceptional association and the importance of its ear ... | 1999 | 10638002 |
| hyperthyroidism after surgery for primary hyperparathyroidism. | the coexistence of hyperthyroidism and primary hyperparathyroidism (phpt) has been reported. we have questioned whether hypercalcemia or surgical trauma contribute to transient hyperthyroidism following parathyroid surgery. | 1999 | 10654273 |
| effect of lithium on thyroidal 131iodine uptake, its clearance, and circulating levels of triiodothyronine and thyroxine in lead-treated rats. | the influence of lead acetate (50 mg per kg body weight) on the 131iodine (131i) biokinetics (uptake and retention) in rat thyroid and serum levels of triiodothyronine (t3) as well as thyroxine (t4) was evaluated as a function of time and in combination with lithium treatment. the 2-h and 24-h uptake of 131i in the thyroid was stimulated significantly by lead treatment. the 24-h uptake showed a maximum stimulation after 4 months of lead treatment. lithium supplementation, however, showed the opp ... | 1999 | 10654347 |
| augmentation of vecuronium-induced neuromuscular block during sevoflurane anaesthesia: comparison with balanced anaesthesia using propofol or midazolam. | we have quantified the potentiating effects of 1.7% sevoflurane (n = 12) on vecuronium-induced neuromuscular block and compared the results with those obtained during balanced anaesthesia with propofol (n = 12) or midazolam (n = 12) in 36 patients. neuromuscular function was monitored using an accelerograph and the train-of-four responses of the adductor pollicis muscle to ulnar nerve stimulation. vecuronium 0.1 mg kg-1 was administered as an intubating dose, and maintenance doses of 0.02 mg kg- ... | 1999 | 10655928 |
| [seasonal changes in the triiodothyronine level of the blood evoked by ultraviolet irradiation in vitro]. | ultraviolet irradiation (lambda = 254 nm) of the whole blood of juvenile bulls in vitro results in a plasmatic t3 increase dependent on the time of exposure. dynamics of the growth of hormone content because of uv varies with season. no negative correlation between plasmatic t3 and t4 in irradiated and non-irradiated blood samples was stated. hence, increased t3 levels in blood after uv irradiation in vitro is a consequence of the output of erythrocyte-deposited hormone rather than photoactivati ... | 1999 | 10656136 |
| the effect of diet composition and feeding state on the response to exercise in feed-restricted horses. | eight thoroughbred horses were used to determine the effects of long-term calorie restriction and diet composition on serum t4 and t3 concentrations and metabolic responses with exercise. horses were randomly assigned to 2 treatment groups (n = 4): group 1, horses were fed a calorie-restricted diet designed to have 70% of the calories from the roughage source (rhr); group 2, horses were fed a calorie-restricted diet designed to have 70% of the calories from the concentrate source (rhc). horses t ... | 1999 | 10659310 |
| exertional rhabdomyolysis in quarter horses and thoroughbreds: one syndrome, multiple aetiologies. | the purpose of this study was to determine if chronic exertional rhabdomyolysis (er) in quarter horses and thoroughbreds represents one or several distinct myopathies. eighteen quarter horses and 18 thoroughbreds with er were selected from cases presented to the veterinary hospital on the basis of a history of er, assessment of muscle histopathology, and serum ck activity before and 4 h post exercise. in addition, 2 of 3 of the following parameters were evaluated: muscle glycogen concentrations, ... | 1999 | 10659313 |
| photodynamic therapy for residual or recurrent cancer of the nasopharynx. | adequate or effective treatments are not always available for most recurrent or residual nasopharyngeal cancers (npc). photodynamic therapy (pdt) using hematoporphyrin derivative (hpd) was evaluated for its effectiveness in treating patients, who conventionally failed, with curative or palliative intent. thirteen patients were treated from march 1994 to november 1998. pdt was given to eradicate tumor cells, debulk tumor mass for other treatment options, and to resolve obstruction. long-term tumo ... | 1999 | 10659546 |
| knee kinetics during functional electrical stimulation induced cycling in subjects with spinal cord injury: a preliminary study. | the purpose of this preliminary study was to describe pedal effectiveness parameters and knee-joint reaction forces generated by subjects with chronic spinal cord injury (sci) during functional electrical stimulation (fes)-induced bicycling. three male subjects (age 33-36 years old), who were post-traumatic sci (asia-modified level a, level t4-c5) and enrolled in an fes rehabilitation program, signed informed consent forms and participated in this study. kinematic data and pedal forces during bi ... | 1999 | 10659804 |
| effectiveness of physiotherapy after meniscectomy. | to evaluate the effect of physiotherapy after partial arthroscopic meniscectomy, we performed a prospective, randomised and partially blinded study. this pilot study was performed from october 1996 to june 1997. the control group received the standard treatment, consisting of verbal and written advice and exercises. the physiotherapy group performed exercises according to a dynamic protocol under the supervision of a physiotherapist. during a 3-week period, nine treatment sessions were given of ... | 1999 | 10639654 |
| evaluation of thyroid hormones in chronic renal failure. | when chronic renal failure becomes advanced, the serum levels of most hormones are altered because of several interplaying mechanisms. this study was carried out to evaluate the level of total thyroxine (t4), triiodothyronine (t3) and thyrotropin (tsh) in 96 clinically euthyriod patient with chronic renal failure and 25 healthy individual as control. the patients were grouped into two groups, 62 patient on conservative management and 34 patients on chronic haemodialysis. the patient of both grou ... | 1999 | 10639771 |
| activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. | to determine whether cytokine release or activation of the hypothalamo-pituitary-adrenal (hpa) axis is predominantly involved in the development of the euthyroid sick syndrome (ess). | 1999 | 10660848 |
| influence of age and sex on vertebral shape indices assessed by radiographic morphometry. | vertebral shape indices (vsi) assessed by radiographic morphometry are currently used to define vertebral fractures in clinical trials and epidemiologic studies on osteoporosis. however, there is little information concerning the influence of sex or age on vsi. furthermore, previous reports on the variation of vsi with age showed conflicting results. the aim of this study was to assess the influence of sex and age on vsi in order to better define reference values for the clinical and epidemiolog ... | 1999 | 10663344 |
| temperature and kclo(4)-induced metamorphosis in the sea lamprey (petromyzon marinus). | larval sea lampreys (petromyzon marinus) were exposed to either a warm (18 degrees c) or a cold (3 degrees c) water temperature and either with (treated) or without (untreated) the presence of potassium perchlorate (kclo4). after 23 weeks, larvae were examined for signs of metamorphosis and serum samples were collected to assay thyroxine (t4) and 3,5,3'-triiodothyronine (t3) concentrations. water temperature did not significantly affect serum t4 or t3 concentrations in untreated larvae and no me ... | 1999 | 10661717 |
| bta test is superior to voided urine cytology in detecting malignant bladder tumours. | in a prospective study, bard bta (bladder tumour antigen) test was compared to voided urine cytology (vuc) in detecting primary and recurrent bladder cancer (bc). | 1999 | 10661829 |
| cell viability and protein turnover in nongrowing bacillus megaterium at sporulation suppressing temperature. | in bacillus megaterium, a temperature that suppresses sporulation (43 degrees c) only slightly exceeds both the optimum growth temperature and the temperature still permitting sporulation (40-41 degrees c). here we show that, when cells grown at 35 degrees c and transferred to a sporulation medium, were subjected to shifts between 35 degrees c and the sporulation suppressing temperature (sst, 43 degrees c), their development and proteolytic activities were deeply affected. during the reversible ... | 1999 | 10664882 |
| radiation therapy and concurrent cisplatin in management of locoregionally advanced nasopharyngeal carcinomas. | radiation therapy in combination with chemotherapy in the management of locoregionally advanced nasopharyngeal carcinomas is evaluated in an attempt to improve locoregional response, reduce locoregional failure and reduce systemic failure. the current study was designed to investigate radiation therapy and concurrent cisplatin in this context. from 1992 through 1997, 70 patients with locoregionally advanced nasopharyngeal carcinomas were treated with radiation therapy and concurrent cisplatin. e ... | 1999 | 10665758 |
| effects of dopexamine on blood flow in multiple splanchnic sites measured by laser doppler velocimetry in rabbits undergoing cardiopulmonary bypass. | decreased gut perfusion has been reported during cardiopulmonary bypass (cpb). studies of treatments to avoid splanchnic ischaemia during cpb have given conflicting results. we studied 12 rabbits during mild hypothermic non-pulsatile cpb. tissue blood flow in three different splanchnic areas (gastric, jejunum and ileum) was measured by laser doppler velocimetry (ldv) before cpb (t0), after steady state (t1), after administration of dopexamine 2 micrograms kg-1 min-1 (t2) and 4 micrograms kg-1 mi ... | 1999 | 10325845 |
| mri of local disease in nasopharyngeal carcinoma: tumour extent vs tumour stage. | the purpose was to use mri to study in detail local tumour extension in patients presenting with nasopharyngeal carcinoma (npc) and to compare the extent of local disease with the current t-stage classification. mr images of 150 patients with newly diagnosed nasopharyngeal carcinoma were obtained on a 1.5 t unit. 10 extranasopharyngeal sites were analysed for tumour involvement. the number of concurrently involved sites was determined. the extent of tumour invasion was compared with staging as d ... | 1999 | 10624338 |
| p27 cell-cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer. | p27, a cyclin-dependent kinase inhibitor, suppresses proliferation of normal and neoplastic cells. expression of p27 is correlated with survival in colon cancer. to some degree, right-sided colon cancers differ biologically and clinically from left-sided colon cancers. we analyzed 41 patients with right-sided colon cancers, including 18 cases with regional lymph node metastases and 23 cases with negative lymph nodes. immunostaining for p27 was performed on histologic sections of primary cancers ... | 1999 | 10633297 |
| overexpression, purification, and partial characterization of adp-ribosyltransferases moda and modb of bacteriophage t4. | there is increasing experimental evidence that adp-ribosylation of host proteins is an important means to regulate gene expression of bacteriophage t4. surprisingly, this phage codes for three different adp-ribosyltransferases, gene products alt, moda, and modb, modifying partially overlapping sets of host proteins. while gene product alt already has been isolated as a recombinant protein and its action on host rna polymerases and transcription regulation have been studied, the nucleotide sequen ... | 1999 | 10634320 |
| nasopharyngeal carcinoma in children under 15 years of age: a retrospective review of 65 patients. | nasopharyngeal carcinoma constitutes comprises up to 5% of primary childhood cancers but literature lacks modern uniformly treated large series. | 1999 | 10643543 |
| parenteral selenium supplementation in extremely low birth weight infants: inadequate dosage but no correlation with hypothyroidism. | selenium is an essential trace element, known to be important in thyroid metabolism. we speculated that parenteral selenium supplementation is inadequate in preterm infants and may contribute to the development of hypothyroidism. | 1999 | 10645521 |
| improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. | we report an improved heterologous radioimmunoassay (ria) for the measurement of thyrotropin (tsh) in mouse serum. the assay components are: antirat thyrotropin (rtsh) serum from the national hormone and pituitary program, a commercial [125i]-labeled rtsh and mouse thyrotropin (mtsh) serum standards produced by dilution of a serum pool from hypothyroid mice with high tsh with a serum pool from mice treated with excess levothyroxine (lt4) (mtsh-0). sensitivity was increased by reducing the amount ... | 1999 | 10646670 |
| acanthamoeba strains isolated from organs of freshwater fishes. | contrary to data on acanthamoeba infections in humans, little is known about infections in fishes. the present study combines the description of strains isolated from fishes with presentation of an improved method for subgeneric classification. acanthamoeba spp. were isolated aseptically from tissues of 14 (1.7%) of 833 asymptomatic fishes collected in rivers and streams in the czech republic. acanthamoebae successfully cloned from 10 of the 14 isolated strains were examined here. morphology of ... | 1999 | 10647044 |
| post-tetanic count and train-of-four responses during neuromuscular block produced by vecuronium and infusion of nicardipine. | we have examined onset and recovery of neuromuscular block produced by vecuronium using either post-tetanic count (ptc), or the first twitch of the train-of-four (tof) (t1/t0) and tof ratio (t4/t1) during continuous infusion of nicardipine. sixty adult patients were allocated to one of four groups of 15 patients each: nicardipine-ptc, nicardipine-tof, control-ptc and control-tof. in the nicardipine-ptc and nicardipine-tof groups, nicardipine 0.03 mg kg-1 was given before vecuronium 0.1 mg kg-1 a ... | 1999 | 10618956 |
| withania somnifera and bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. | the effects of daily administration of withania somnifera root extract (1.4 g/kg body wt.) and bauhinia purpurea bark extract (2.5 mg/kg body wt.) for 20 days on thyroid function in female mice were investigated. while serum triiodothyronine (t3) and thyroxine (t4) concentrations were increased significantly by bauhinia, withania could enhance only serum t4 concentration. both the plant extracts showed an increase in hepatic glucose-6-phosphatase (g-6-pase) activity and antiperoxidative effects ... | 1999 | 10619390 |
| muscle mass and function in thyrotoxic patients before and during medical treatment. | development of muscle weakness and atrophy are well known complications of thyrotoxicosis, although little is known about its clinical course. the present longitudinal study was therefore undertaken to monitor muscle mass and strength before and during treatment of hyperthyroidism. | 1999 | 10619973 |
| initial characterization of the gh-igf axis and nutritional status of the ati negritos of the philippines. | the ati negritos are a pygmy-like aboriginal population from the philippines with physical characteristics of short stature, dark skin and woolly, kinked hair. their final height, components of their gh-igf axis and various nutritional markers are described. subjects, design and measurements: auxological data and sera for the components of the gh-igf axis and nutritional parameters were collected from 9 adult ati negritos in their native environment and 10 filipinos in sydney. | 1999 | 10619979 |
| cardiovascular responses to intrathecal dopamine receptor agonists in conscious doca-salt hypertensive rats. | previous studies have demonstrated that in conscious deoxycorticosterone acetate (doca)-salt hypertensive rats, the hypotensive action of intravenous (i.v.) bromocriptine, a selective dopamine d2 receptor agonist, was mediated partly by peripheral and partly by spinal dopamine d2 receptor stimulation, and that this effect was greater and longer-lasting than that in uninephrectomized control rats. to determine whether this amplification results partly from a putative spinal hypersensitivity pheno ... | 1999 | 10626749 |
| the phototumorigenic fluoroquinolone lomefloxacin photosensitizes pyrimidine dimer formation in human keratinocytes in vitro. | the fluoroquinolone antibiotic lomefloxacin is phototoxic, photogenotoxic, photomutagenic and photosensitizes tumorigenesis in mouse skin. we have used t4 endonuclease v to demonstrate that lomefloxacin photosensitizes pyrimidine dimer formation in a human keratinocyte line (hacat). a possible mechanism for this effect would be triplet-triplet energy transfer. however, there is indirect evidence that the lomefloxacin triplet yield is very low, making this reaction less likely. the finding that l ... | 1999 | 10628309 |
| neuroendocrine responses following graded traumatic brain injury in male adults. | in an effort to characterize thyroid, gonadal and adrenal function following neurotrauma, the present study determined serum concentrations of thyroid-stimulating hormone (tsh), total triiodothyronine (t3), thyroxine (t4), testosterone and cortisol over a 7 day period in 31 patients with traumatic brain injury. the study group consisted of eight patients with mild closed head injury (glasgow coma scale--gcs 13-15), 10 patients with extensive penetrating head injury (gcs 4-6) and 13 patients with ... | 1999 | 10628505 |
| [controversies in the new tnm staging system]. | the latest revision of the international system for staging lung cancer was published in june 1997. we discuss the following 4 major items in the new tnm staging system. 1) the fact that stage i was divided into stage ia (t1n0m0) and ib (t2n0m0) is reasonable, as the survival prospects for the subsets differ significantly. 2) the fact that stage ii was divided into stage iia (t1n1m0) and iib (t2n1m0) is not appropriate, however, there is no significant survival difference between the t1n1m0 subs ... | 1999 | 10629834 |
| [the prevalence of thyroid functional disorders in the province of lleida]. | to assess the prevalence of thyroidal disorders in our area using a representative sample of the population in terms of age and distribution by sex. | 1999 | 10630030 |
| [conservative treatment of anal canal carcinoma with external radiotherapy and interstitial brachytherapy, with or without chemotherapy: long-term results]. | a retrospective analysis of conservative treatment of anal canal cancers with external radiation therapy and interstitial brachytherapy with or without chemotherapy. | 1999 | 10630158 |
| enhanced chemotaxis of macrophages by strenuous exercise in trained mice: thyroid hormones as possible mediators. | exercise modulates the macrophage activity via 'stress hormones'. three experiments were performed. (1) the effect of strenuous exercise performed by trained mice on macrophage chemotactic capacity was evaluated; (2) peritoneal macrophages from control mice were incubated with plasma from exercised mice or control mice and the differences in chemotaxis were measured; (3) changes in plasma t3 and t4 levels after exercise were measured, and the effect of incubation with the post-exercise levels of ... | 1999 | 10630621 |
| evaluation of antioxidant status in liver tissues: effect of iron supplementation in experimental hyperthyroidism. | the antioxidant defense system in liver tissue in experimental hyperthyroidism and/or in iron supplementation was investigated. thyroid hormones (t3, t4, tsh), ferritin (marker of iron status), antioxidant status components (glutathione [gsh], glutathione peroxidase [gsh-px], superoxide dismutase [sod]), and serum transaminases (got and gpt, both of which are known to be released from damaged hepatocytes), were measured. hyperthyroidism in rats, induced by l-thyroxine administration, significant ... | 1999 | 10631595 |
| thyroid function and effects on reproduction in ewes exposed to the organochlorine pesticides lindane or pentachlorophenol (pcp) from conception. | there is concern over the potential endocrine-modulating effects of long-term exposure to pesticides. in this study, ewe lambs were exposed to lindane and pentachlorophenol (pcp) from conception to necropsy at 67 wk. of age. the ewe lambs (and their mothers) were given untreated feed (n = 6) or feed treated with 1 mg/kg body weight/day of lindane (n = 8) or pcp (n = 13). estrus was synchronized at 32 wk. of age, and ewe lambs were exposed to vasectomized rams. ewe lambs were then exposed to inta ... | 1999 | 10632142 |
| retromolar trigone tumors: evaluation by magnetic resonance imaging and correlation with pathological data. | the aim of this study was to evaluate the diagnostic accuracy of magnetic resonance (mr) images to establish both the t stage and the relationships between the tumors and the surrounding structures in retromolar trigone tumors. twenty-two patients with squamous cell carcinoma of the retromolar trigone were examined by mr with a superconductive scanner operating at 1.5t. the study was performed with spin-echo (se) t1 and t2 and short se t1 sequences (tr 180 ms, te 15 ms) after the administration ... | 1999 | 10632555 |
| intracellular phosphorylation of zidovudine in an in vitro hollow fiber model. | combination antiretroviral therapy that includes zidovudine has proved much better in treating human immunodeficiency virus infection than monotherapy diminished responses to zidovudine, especially when it was given alone, was likely due to factors including interpatient variability in pharmacokinetics, nonadherence, emergence of resistant mutants, and reduced cellular enzymatic processes to phosphorylate the drug. this study evaluated the intracellular metabolism of zidovudine up to 6 weeks usi ... | 1999 | 10453969 |
| the carboxyl terminus of the bacteriophage t4 dna polymerase contacts its sliding clamp at the subunit interface. | the location of the interaction of the cooh terminus of the bacteriophage t4 dna polymerase with its trimeric, circular sliding clamp has been established. a peptide corresponding to the cooh terminus of the dna polymerase was labeled with a fluorophore and fluorescence spectroscopy used to show that it forms a specific complex with the sliding clamp by virtue of its low k(d) value (7.1 +/- 1.0 microm). the same peptide was labeled with a photoaffinity probe and cross-linked to the sliding clamp ... | 1999 | 10455110 |
| mutational and ph studies of the 3' --> 5' exonuclease activity of bacteriophage t4 dna polymerase. | the 3' --> 5' exonuclease activity of proofreading dna polymerases requires two divalent metal ions, metal ions a and b. mutational studies of the 3' --> 5' exonuclease active center of the bacteriophage t4 dna polymerase indicate that residue asp-324, which binds metal ion a, is the single most important residue for the hydrolysis reaction. in the absence of a nonenzymatic source of hydroxide ions, an alanine substitution for residue asp-324 reduced exonuclease activity 10-100-fold more than al ... | 1999 | 10455197 |
| [economic evaluation od the value of early diagnosis and management of hypothyroidism in hypercholesterolemia]. | the aim of the study was to assess the economic consequences of the early screening and management for overt hypothyrodism in elderly women suffering from hypercholesterolaemia. | 1999 | 10615519 |
| [squamous cell carcinoma of the head and neck and pulmonary cancer. report of 50 cases]. | association of a squamous cell carcinoma of the head and neck and a pulmonary cancer is frequent: prevalence is about 5 to 10 percent. the purpose of this study was to present the survival analysis of 50 patients, previously treated for a squamous cell carcinoma of the head and neck, and then treated for a pulmonary cancer between 1979 and 1996. four patients were excluded from the analysis. five pulmonary cancers were synchronous with the head and neck cancer, 41 were metachronous. metachronous ... | 1999 | 10615525 |
| nutrition, thyroid function and basal metabolism of the evenki of central siberia. | considerable research has shown that indigenous circumpolar populations have elevated basal metabolic rates (bmr). such elevations are likely promoted by changes in thyroid hormone levels; however, to date, this link between thyroid function and variation in bmr has not been explicitly demonstrated in an indigenous northern group. thus, the purpose of this paper is to examine 1) the influence of dietary and nutritional factors on variation in thyroid hormone levels, and 2) the influence of thyro ... | 1999 | 10615833 |
| sensitivity of bacteriophage rb69 dna polymerase to n2-(p-n-butylphenyl)-2'-deoxyguanosine nucleotides. | the response of bacteriophage rb69 dna polymerase to n2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate (bupdgtp), related nucleotides and non-nucleoside inhibitors was measured and compared to values obtained for the closely related dna polymerase from bacteriophage t4. both enzymes showed similar responses to inhibitors in terms of ki values and the ability to utilize bupdgtp as a substrate. these results provide the relevance of using the recent crystal structure of rb69 dna polymerase fo ... | 1999 | 10616725 |
| structure and folding of bacteriophage t4 gene product 9 triggering infection. i. production and properties of recombinant protein. | gene product 9 (gp9, 288 amino acid residues per monomer, molecular weight 30.7 kd) of bacteriophage t4 triggers the baseplate reorganization and the sheath contraction after interaction of the long tail fibers with the receptors of the bacterial cell. in this work we have produced the recombinant protein and determined that gp9 is a stable homotrimer and active in in vitro complementation assay completing the defective phage particles which lack gp9. according to cd-spectroscopy data, the gp9 p ... | 1999 | 10611531 |
| dose- intensified, preoperative and adjuvant chemotherapy in patients with t3- and t4- breast cancer: toxicity, clinical and pathological remission. | the aim of the study was to investigate a dose-intensified, preoperative chemotherapy with 3 cycles (cy) of epirubicin 60 mg/m2, ifosfamide 5 g/m2 with mesna 5 g/m2, biweekly with g-csf 5 micrograms/kg (filgrastim), in terms of toxicity, clinical and pathological remission rates and changes of immunohistochemical characteristics (er, pr, c-erbb2, p53) during chemotherapy of inoperable patients (pt) with poor prognosis (locally advanced (labc, 9 pt), inflammatory breast cancer (ibc, 12 pt) and m0 ... | 1999 | 10612219 |
| long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. | the aim of the study was to evaluate serum thyroid hormone balance in children receiving long-term therapy with carbamazepine (cbz), valproate (vpa), and phenobarbital (pb). | 1999 | 10612341 |
| hyperthyroidism decreases thyrotropin-releasing hormone gene expression in the caudal raphe nuclei and the parapyramidal regions in rats. | altered thyroid statuses are associated with autonomic disorders. medullary thyrotropin-releasing hormone (trh) and substance p (sp) regulate autonomic nervous activity. the influences of thyroid statuses on trh and sp gene expressions in the caudal raphe nuclei and the parapyramidal regions were studied using quantitative in situ hybridization histochemistry. in male rats thyroidectomized (tx) for 30 days, the serum t4 levels decreased by 64% and the medullary pro-trh mrna signals (silver grain ... | 1999 | 10612637 |
| survival and postoperative complications after extended surgery for non-small-cell lung cancer. a retrospective study. | we evaluated survival after extended surgery in patients with non-small-cell lung cancer and the effects of induction therapy on results and complications. | 1999 | 10614094 |
| [patterns of initial treatment failure of esophageal cancer following radiotherapy]. | sixty patients with stage i-iii esophageal squamous cell cancer treated by definitive radiotherapy (rt) were analyzed for patterns of treatment failure. patients were treated by external rt alone (n = 45) or in combination with intraluminal rt (n = 15) when suitable, with prescribed total doses ranging from 59.4 to 104.4 gy. concurrent chemotherapy consisting of cisplatin and/or 5-fluorouracil was administered to 19 patients. the two-year actuarial survival rate and two-year disease-free surviva ... | 1999 | 10614106 |
| [cervical lymphnode metastasis of early or late t2 tongue carcinoma]. | between 1986 and 1997, 72 patients (47 males, 25 females) with previously untreated tongue cancer were treated at our institution (surgery: 67, interstitial radiotherapy: 3, palliative therapy: 2). these patients, especially t2 tongue cancer, were classified into two groups (early t2: < or = 3 cm, late t2: > 3 cm) according to the maximum diameter of the primary lesion, and were analyzed for treatment outcome and cervical lymphnode metastasis. (1) the cumulative 5-year survival rates were 65.9% ... | 1999 | 10614116 |
| [a case of acute transverse myelopathy and bilateral optic neuritis associated with anticardiolipin antibodies, lupus anticoagulant and perinuclear antineutrophil cytoplasmic antibodies]. | a 69-year-old woman developed paraplegia and hypesthesia on upper extremities and below t4 level. examination of cerebrospinal fluid showed increased protein levels and pleocytosis. mri of the cervical spinal cord revealed syrinx formation from c3 to upper thoracic cord. a diagnosis of acute transverse myelitis was made. a high dose of corticosteroid including pulse therapy did not improve her symptoms and signs of myelopathy, but the syrinx could not be found thereafter. one year later, she dev ... | 1999 | 10614163 |
| extending low-dose epidural analgesia for emergency caesarean section. a comparison of three solutions. | we conducted a prospective double-blind randomised trial to compare bupivacaine 0.5%; a 50 : 50 mixture of bupivacaine 0.5%/lignocaine 2% with 1 : 200 000 adrenaline (final concentration); and lignocaine 2% with 1 : 200 000 adrenaline for converting a low-dose labour epidural into a block adequate for emergency caesarean section. ninety patients were studied, 30 in each group. there was no difference between the groups in the time taken for bilateral loss of cold sensation to reach t4. onset tim ... | 1999 | 10594415 |
| comparison of the effects of desflurane and isoflurane anaesthesia on hepatocellular function assessed by alpha glutathione s-transferase. | the purpose of this study was to investigate the influence of isoflurane and desflurane on hepatocellular function. twenty male patients undergoing elective surgery were randomly assigned to receive either isoflurane or desflurane anaesthesia. alpha glutathione s-transferase concentrations and aminotransferase activities were measured at induction of anaesthesia (t0), 15 min (t1), 90 min after induction (t2), end of surgery (t3) and 2 h thereafter (t4). a significant increase in alpha glutathion ... | 1999 | 10594421 |
| serum thyroxine binding capacity-dependent bias in an automated free thyroxine assay. | the magnitude of serum thyroxine (t4) binding capacity (sbc) dependent bias in the axsym free thyroxine (ft4) assay was assessed using two recently described tests. one of the tests uses a direct equilibrium dialysis (ed) ft4 assay as the reference method. the results obtained with the axsym method were compared with those obtained by the ed ft4 method in patient sera having a wide range of sbc. the other test involves comparison of the ft4 results obtained following dilution of sera by an inert ... | 1999 | 10595855 |
| [a superior vena cava syndrome due to a surgical retractor]. | a 56-year-old male diagnosed of epidermoid carcinoma of the right lung (t4 n0 m0, stage iiib) is described. he had earlier received chemotherapy and radiotherapy and was scheduled for removal of the right lung. during surgery the need to resect tumor infiltration of the right atrium became evident. during weaning from by-pass sudden deterioration of hemodynamics occurred with poor response to volume and inotropic drugs. superior vena cava syndrome due to traction of the innominate trunk from a s ... | 1999 | 10596345 |
| thyroid hormone modulates insulin-like growth factor-i(igf-i) and igf-binding protein-3, without mediation by growth hormone, in patients with autoimmune thyroid diseases. | the expression and synthesis of insulin-like growth factor-1 (igf-i) and igf-binding protein-3 (igfbp-3) are regulated by various hormones and nutritional conditions. we evaluated the effects of thyroid hormones on serum levels of igf-i and igfbp-3 levels in patients with autoimmune thyroid diseases including 54 patients with graves' disease and 17 patients with hashimoto's thyroiditis, and in 32 healthy age-matched control subjects. patients were subdivided into hyperthyroid, euthyroid and hypo ... | 1999 | 10596968 |
| autoimmune thyroid disorders in juvenile chronic arthritis and systemic lupus erythematosus. | the appearance of autoimmune thyroiditis in the course of other autoimmune diseases, which do not affect specific organs (systemic lupus erythematosus, sjögren syndrome, rheumatoid arthritis and others), is more frequent than is usually believed. nevertheless, it is scarcely studied, especially in children. the purpose of this study was to look for autoimmune lesions of the thyroid gland in children suffering from juvenile chronic arthritis (jca) and systemic lupus erythematosus (sle). twenty se ... | 1999 | 10599323 |
| diagnosis of hidden central hypothyroidism in survivors of childhood cancer. | to determine how often central hypothyroidism remains undetected by routine out-patient tests of thyroid hormone, we studied 208 pediatric cancer survivors referred for evaluation because of signs of subtle hypothyroidism or hypopituitarism. of the 208 (68 females and 140 males), 110 had brain tumors, 14 had other head/neck tumors, 11 had solid tumors remote from head and neck, and 73 had leukemia. patients were evaluated 1-16 yr (mean, 6.1+/-4.1 yr) after tumor diagnosis. the nocturnal tsh surg ... | 1999 | 10599705 |
| levothyroxine suppression of thyroglobulin in patients with differentiated thyroid carcinoma. | for patients with differentiated thyroid carcinoma, the appropriate degree of tsh suppression by levothyroxine (l-t4) is still unknown. to find the target level of tsh suppression, we analyzed the relationship between the degree of tsh suppression determined by third generation assay and thyroglobulin (tg) response during the titration of the dosage of l-t4. ninety-two patients with differentiated thyroid carcinoma (19 males and 73 females; age, 40.5+/-13.5, mean +/- sd) were included. all of th ... | 1999 | 10599717 |
| relationship between hexamerization and ssdna binding affinity in the uvsy recombination protein of bacteriophage t4. | in bacteriophage t4, homologous genetic recombination events are catalyzed by a presynaptic filament containing stoichiometric quantities of the t4 uvsx recombinase bound cooperatively to single-stranded dna (ssdna). the formation of this filament requires the displacement of cooperatively bound gp32 (the t4 ssdna-binding protein) from the ssdna, a thermodynamically unfavorable reaction. this displacement is mediated by the t4 uvsy protein (15.8 kda, 137 amino acids), which interacts with both u ... | 1999 | 10600121 |
| review: electron crystallography: present excitement, a nod to the past, anticipating the future. | from a modest beginning with negatively stained samples of the helical t4 bacteriophage tail, electron crystallography has emerged as a powerful tool in structural biology. high-resolution density maps, interpretable in terms of an atomic structure, can be obtained from specimens prepared as well-ordered, two-dimensional crystals, and the resolution achieved with helical specimens and icosahedral viruses is approaching the same goal. a hybrid approach to determining the molecular structure of co ... | 1999 | 10600552 |
| [iodine therapy for iodine deficiency goiter and autoimmune thyroiditis. a prospective study]. | there is epidemiological and clinical evidence that iodine may induce or promote the manifestation of autoimmune thyroiditis. for this reason it is important to know if substitution of alimentary iodine deficiency or iodine treatment of endemic goitre can cause formation of thyroid antibodies. on the other hand the practical importance of this phenomenon should be evaluated. | 1999 | 10603730 |
| relation between endoscopic ultrasound evaluation and survival of patients with inoperable thoracic squamous cell carcinoma of the oesophagus treated by combined radio- and chemotherapy. | purpose of this study was to assess prognostic value of endoscopic ultrasound in patients with inoperable squamous cell carcinoma of oesophagus treated by radio-chemotherapy. | 1999 | 10604099 |