Publications

reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.	anchorage and growth factor independence are cardinal features of the transformed phenotype. although it is logical that the two pathways must be coregulated in normal tissues to maintain homeostasis, this has not been demonstrated directly. we showed previously that down-modulation of beta1-integrin signaling reverted the malignant behavior of a human breast tumor cell line (t4-2) derived from phenotypically normal cells (hmt-3522) and led to growth arrest in a three-dimensional (3d) basement m ...	1998	9843973
bacteriophage t4 initiates bidirectional dna replication through a two-step process.	two-dimensional gel analysis of the bacteriophage t4 ori(uvsy) region revealed a novel "comet" on the y arc. this comet contains simple y molecules in which the branch points map to the ori(uvsy) transcript region. the comet depends on the the origin and dna synthesis and is abolished by a mutation that reduces replication without affecting transcription. these results argue that the branched molecules are intermediates in replication initiation. a transcriptional terminator, cloned just downstr ...	1998	9844641
continuous hyperfractionated accelerated radiotherapy with/without mitomycin c in head and neck cancer.	to evaluate the effect of mitomycin c to an accelerated hyperfractionated radiation therapy. the aim was to test a very short schedule with/without mitomycin c (mmc) with conventional fractionation in histologically verified squamous cell carcinoma of the head and neck region.	1998	9845100
concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a phase ii study.	to evaluate the efficacy and toxicity of tirapazamine, a hypoxic cytotoxin, combined with conventional radiotherapy (rt) for advanced head and neck carcinomas.	1998	9845102
port site recurrences after laparoscopic surgery. a review.	port site metastasis has been a surprising event after laparoscopic procedures in cancer patients. no clear data exist about this phenomenon. the aim of this study is to summarize current epidemiologic knowledge about the risk of this complication. a review of all case reports about port site recurrences was undertaken. to date, 164 cases of port site metastases after videoscopic procedures have been reported in 90 papers. we found 108 cases of implantation after laparoscopy for digestive tumors ...	1998	9845574
surgical treatment of locally advanced rectal cancer. options and strategies.	the results of surgical treatment of locally advanced rectal cancer with special regard to multivisceral resections and preoperative radiotherapy should be analyzed.	1998	9845611
[ability of erythrocytes to deposit thyroid hormones: regulatory role of physico-chemical factors in vitro].	data obtained suggest the existence of regulation mechanism controlling parameters of thyroid status, that does not require any modification of thyroid gland secretory function. the realisation of this mechanism can involve hormone-depositing function of blood erythrocytes, which is sensitive to a) change of regional or systemic ph and b) change of hematocrit. results of the present study indicate that mammalian erythrocytes are able to bind considerable quantities of t3 and t4 and, t3 binding i ...	1998	9845926
plasma levels of selenium, selenoprotein p and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on latvian fish consumers.	to study the relationships between fish intake and different markers of selenium status and thyroid hormone function.	1998	9846591
continuous hyperfractionated accelerated radiotherapy in advanced head and neck malignancies.	58 patients of advanced head and neck cancer were treated by continuous hyperfractionated accelerated radiotherapy (study group) or conventional radiotherapy (control group). the study group of 29 patients had 26/29 (89%) of patients of stage t3 and t4 with 12/29 (41% 0) > n2 disease. the schedule employed was 1.5 gy 3 times a day in 36 fractions on 12 treatment days without stopping for weekends. the spinal dose has been kept at 40.5 gy and interfraction interval has been strictly kept at 6 hrs ...	1998	9847466
thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to aroclor 1254 in rats.	the nervous system is dependent upon thyroid hormones for normal development, and we previously reported that developmental aroclor 1254 (a1254) exposure caused hypothyroxinemia, hearing loss and other behavioral changes in rats. (goldey et al., 1995a; herr et al., 1996). the hypothesis that a1254-induced hypothyroxinemia may have contributed to the observed functional changes was tested in primiparous long-evans rats given daily oral doses of corn oil (control) or 8 mg/kg of aroclor 1254 from g ...	1998	9848116
pelvic exenteration for advanced primary rectal cancer in male patients.	between november 1987 and january 1996 pelvic exenteration for primary rectal cancer was carried out in 11 male patients. two underwent a primary resection with subtotal cystectomy. in the remaining nine patients, the treatment commenced with a staging laparotomy and the fashioning of an end colostomy of the descending colon, followed by preoperative radiotherapy (50-56 gy in 5 weeks). total exenteration with uretero-ileo-cutaneostomy was carried out 4-6 weeks later. in two patients, the exenter ...	1998	9848333
thyroid dysfunction and nodular goiter in hemodialysis and peritoneal dialysis patients.	to investigate the prevalence of nodular goiter and thyroid dysfunction in uremic patients undergoing hemodialysis (hd) and peritoneal dialysis.	1998	9848631
neomycin b inhibits splicing of the td intron indirectly by interfering with translation and enhances missplicing in vivo.	the aminoglycoside antibiotic neomycin b inhibits translation in prokaryotes and interferes with rna-protein interactions in hiv both in vivo and in vitro. hitherto, inhibition of ribozyme catalysis has only been observed in vitro. we therefore monitored the activity of neomycin b and several other aminoglycoside antibiotics on splicing of the t4 phage thymidylate synthase (td) intron in vivo. all antibiotics tested inhibited splicing, even chloramphenicol, which does not inhibit splicing in vit ...	1998	9848660
the neuropeptides, vip and npy, that are present in the thyroid nerves are not released into the thyroid vein.	in the present study, we tested the hypothesis that the neuropeptides, vasoactive intestinal peptide (vip) and neuropeptide y (npy), which are present in the thyroid nerves, act as physiological neurotransmitters involved in the regulation of thyroid hormone secretion and thyroid blood flow. specifically, we examined whether these neuropeptides can be released into thyroid blood vessels by electrical stimulation of the major thyroid nerves or whether their expression is altered by changes in iod ...	1998	9848726
thyroxine administration to infants of less than 30 weeks gestational age decreases plasma tri-iodothyronine concentrations.	to investigate the effect on thyroid hormone metabolism of the administration of thyroxine to very preterm infants.	1998	9849815
decrease in plasma levels of vasoactive intestinal polypeptide in short bowel syndrome: experimental study.	to investigate the behaviour of the vasoactive intestinal polypeptide (vip) in short bowel syndrome (sbs), an experimental model of massive intestinal resection (mir) was developed. for this purpose, 20 'minipigs' were divided into two experimental groups: a (control) and b (mir). the parameters determined were the mean plasma levels of vip and the degree of steatorrhea at four different times: t1 (basal), t2 (one week after surgery), t3 (two weeks after surgery), and t4 (24 weeks after surgery) ...	1998	9851334
the prediction of the prognosis for rectal carcinoma down-staged by pre-operative radiotherapy by transrectal ultrasonography.	we attempted to determine whether the results of transrectal ultrasonography (trus) could provide any prognostic information about patients with rectal carcinoma treated with pre-operative radiotherapy (rt).	1998	9851337
molecular diagnosis of residual and recurrent thyroid cancer by amplification of thyroglobulin messenger ribonucleic acid in peripheral blood.	serum thyroglobulin measurement by immunoassay is used to detect residual or recurrent thyroid cancer after thyroid ablation. however, the usefulness of immunoassay is limited by both the requirement for thyroid hormone withdrawal to attain optimal test sensitivity and interference by antithyroglobulin antibodies. to circumvent these problems, we amplified thyroglobulin messenger ribonucleic acid (mrna) in peripheral blood using rt-pcr and compared the accuracy of this test to serum thyroglobuli ...	1998	9851791
abortive initiation of transcription at a hybrid promoter. an analysis of the sliding clamp activator of bacteriophage t4 late transcription, and a comparison of the sigma70 and t4 gp55 promoter recognition proteins.	bacteriophage t4 late promoters are transcribed by an rna polymerase holoenzyme comprising the escherichia coli core, e, the phage gene 55-encoded promoter recognition subunit, gp55, and the gene 33-encoded co-activator, gp33. transcriptional initiation is activated by the t4 gene 45-encoded sliding clamp, which is loaded on to dna at enhancer-like sites by its clamp-loader. correct initiation of transcription at late promoters in basal mode requires only rna polymerase core and gp55 (e.gp55). d ...	1998	9852060
substrate mutations that bypass a specific cpn10 chaperonin requirement for protein folding.	the bacteriophage t4 groes homologue, gp31, in conjunction with the escherichia coli chaperonin groel, is both necessary and sufficient to fold the t4 major capsid protein, gp23, to a state competent for capsid assembly as shown by in vivo expression studies. groes is unable to function in this role as a productive co-chaperonin. the sequencing and characterization of mutations within gp23 that confer groel and gp31 chaperonin-independent folding of the mutant protein suggest that the chaperonin ...	1998	9852065
correlation of activated monocytes or b cells with t lymphocyte subsets in patients with graves' disease.	we analyzed the phenotypic characteristics of pbmc from 34 patients with graves' disease (gd) at different stages of the disease to explore the sequence of immunological events associated with it. in all cases their monocytes were in a state of activation and differentiation more advanced than those of a group of 23 healthy individuals. strikingly, some patients had cd14++dr- immature monocytes, which were absent in healthy individuals. cd14+cd16+drhigh monocytes were more abundant in patients. ...	1998	9852205
metachronous cancer: prognostic factors including prior irradiation.	in this article we evaluate two factors that may be responsible for the reported increased mortality rate in metachronous cancers: prior radiation therapy and stage at presentation. a select group of 358 patients was split into three groups: no prior cancer (group 1), prior cancer treated with radiation therapy (group 2), and prior cancer treated with surgery alone (group 3). we compared survival among the three groups according to stage (t1 or t2 vs. t3 or t4) using the lifetest procedure. surv ...	1998	9852536
segmental specificity of chick sympathetic preganglionic projections is influenced by preganglionic neurons from neighboring spinal cord segments.	sympathetic preganglionic neurons of the chick are located between the brachial and lumbosacral enlargements of the spinal cord. their axons exit the spinal cord via their adjacent ventral roots and project rostrally or caudally along the sympathetic trunk to innervate sympathetic ganglia. the projections of sympathetic preganglionic neurons are segmentally specific. neurons from the 16th cervical (c16) and the first thoracic (t1) spinal cord segments project predominantly in the rostral directi ...	1998	9852585
effects of postprandial hyperlipemia on the vitamin e content of lipoproteins. gerbap section lipoprotéines. groupe d'evaluation et de recherche de l'assistance publique des hôpitaux de paris.	delayed postprandial clearance of triglyceride-rich lipoproteins (tgrl) could induce a decrease of low-density lipoprotein (ldl) and high-density lipoprotein (hdl) vitamin e content through its transfer into tgrl. we thus studied lipoprotein vitamin e content during postprandial hypertriglyceridemia induced by a high fat meal without vitamin e supplement. venous blood was drawn from five healthy male volunteers following a 12 h fast at (t0) then 2 h (t2), 4 h (t4), 6 h (t6) and 8 h (t8) after a ...	1998	9853697
hypoplastic anaemia complicating myxoedema coma.	the case of a 68 year old women presenting in myxoedema coma is described. she was found to be anaemic with a haemoglobin of 8.2 g/dl. further investigations showed a pancytopenia and a hypoplastic anaemia confirmed by bone marrow. the patient recovered and became euthyroid following initial treatment with intravenous tri-iodothyronine (t3) and later oral thyroxine (t4) replacement with resolution of pancytopenia and return of bone marrow to normal.	1998	9854303
radiation therapy and concurrent daily intra-arterial infusion of low-dose cisplatin following alteration of pelvic blood flow for invasive bladder cancer: a preliminary report.	concurrent intra-arterial infusion chemotherapy and radiation therapy following alteration of pelvic blood flow was performed in 15 patients with invasive bladder cancer (t2: 2, t3a: 4, t3b: 5, t4: 4). infusion chemotherapy consisted of a daily low-dose of cisplatin with a dose range of 7 to 9 mg per patient. of the 15 patients, 11 achieved complete response (73%) and other had partial response. four of those with cr developed recurrence (local recurrence in three and distant metastasis in one p ...	1998	9854485
seasonality of meal patterns and hormonal correlates in red deer.	two groups of six adult, castrated, male red deer were housed under natural daylength conditions and at ambient temperature at 57 degrees n and fed ad lib. (al) or at a fixed rate of 50 g/kg0.75 initial liveweight per day throughout the study (restricted, r). mean daily intakes of al animals were higher during periods of long daylength than during short daylength (p < 0.001). the higher rates of food intake during periods of long daylength were a function of greater meal durations (p < 0.001), s ...	1998	9855479
carboxyflavins, novel inhibitors of taq dna polymerase.	carboxyflavins were found to be potent selective inhibitors of taq dna polymerase in a polymerase chain reaction. the inhibitions were dose-dependent, and complete inhibitions were observed at the concentration of 3.0 microm. carboxyflavins were much less, or not sensitive to the dna polymerases tested such as calf thymus dna polymerase alpha, rat dna polymerase beta, human immunodeficiency virus type 1 reverse transcriptase, the klenow fragment of e. coli dna polymerase i and t4 dna polymerase. ...	1998	9855699
additive effect of nitric oxide inhalation on the oxygenation benefit of the prone position in the adult respiratory distress syndrome.	the response to inhaled nitric oxide and prone positioning was investigated in 47 patients with adult respiratory distress syndrome to test the hypothesis that inhalation of nitric oxide when in the prone position would result in additive improvement in oxygenation.	1998	9856714
telomere length, telomerase activity and telomerase rna expression during mouse mammary tumor progression.	to investigate the roles of telomere length (mean length of the terminal restriction fragments; trfs), telomerase activity (ta) and telomerase rna (mtr) expression in relation to mouse mammary tumor progression, we examined a pregnancy-dependent mouse mammary tumor line (tpdmt-4) and its four autonomous sublines (t4-oi320: non-metastatic; and t4-oi165, -oi96, and -oi145: artificial metastatic) of ddd/1 mouse origin, and an autonomous growing mammary tumor (jyg-mc) showing spontaneous lung metast ...	1998	9857231
the tsh-dependent variation of the essential elements iodine, selenium and zinc within human thyroid tissues.	instrumental neutron activation analysis was used in order to measure iodine, selenium and zinc concentration in thyroid samples. a pair of samples of normal and nodular tissue were collected from the thyroid gland from 72 patients selected on the basis of pathological criteria (44 cases of multinodular goiter, 12 of chronic lymphocytic thyroiditis (clt), 6 of thyroid adenoma (ta) and 12 of thyroid cancer (tc)). the check for tissue homogeneity and sampling error was performed by means of the co ...	1998	9857330
[thyroid hormones in old german black pied- and holstein-friesian suckling calves. effects of parturition and postpartum adaptation].	the present trial deals with the effects of birth stress on the thyreoidea respectively on the thyroxine- and triiodthyronine-concentration as well as on their unbound fraction (ft4 and ft3) of suckler calves and the evolution of those parameters in the first three months of life. t4- and t3 concentrations in blood serum of calves were beyond maternal levels increasing significantly in the first 24 hours with strong individual specificity and reaching levels of adult animals at the end of the th ...	1998	9857410
several new bacteriophage t4 genes, mapped by sequencing deletion endpoints between genes 56 (dctpase) and dda (a dna-dependent atpase-helicase) modulate transcription.	we have analyzed dna of wild-type t4 and of 13 independent large viable deletions isolated by homyk and weil (virology 61 (1974) 505-523) and by little (virology 53 (1973) 47-59), by sequencing, cloning, and expression studies. the deletions can be explained by illegitimate recombination between short (4- to 15-bp) ectopic repeats. in four deletions, adjacent regions are partially homologous, and in at least one of them, the base adjacent to the overlap was deleted during recombination. the sequ ...	1998	9858714
[high dosage thyroxine treatment in therapy and prevention refractory patients with affective psychoses].	the following review summarizes current knowledge on the treatment of therapy-resistant patients with affective disorders with supraphysiological doses of thyroxine (t4). several groups have reported independently of each other that administration of 200-500 micrograms t4/day has excellent effects in 50-65% of patients a) with bipolar disorder, with or without, "rapid cycling" course, who were previously resistant to all prophylactic drugs and b) in the treatment of therapy-resistant depression. ...	1998	9859125
variations in posteroanterior stiffness in the thoracolumbar spine: preliminary observations and proposed mechanisms.	evaluation of posteroanterior (pa) movement in the spine is commonly used in the clinic, but little is known about the mechanisms involved. the purposes of this study were to examine variations in pa stiffness along the thoracolumbar spine and to investigate possible factors that might determine the pattern of stiffness.	1998	9859947
stimulation of bacteriophage t4 middle transcription by the t4 proteins mota and asia occurs at two distinct steps in the transcription cycle.	the bacteriophage t4 encodes proteins that are responsible for tightly regulating mrna synthesis throughout phage development in escherichia coli. the three classes of t4 promoters (early, middle, and late) are utilized sequentially by the host rna polymerase as a result of phage-induced modifications. one such modification is the tight binding of the t4 asia protein to the sigma70 subunit of the rna polymerase. this interaction is pivotal for the transition between t4 early and middle transcrip ...	1998	9860954
mivacurium compared with succinylcholine in children with liver disease.	we have compared mivacurium and succinylcholine in 27 paediatric patients with mild (child's a) to moderate (child's b) liver disease undergoing oesophagogastroduodenoscopy (ogd) and injection of oesophageal varices, with 10 healthy children receiving mivacurium for ent procedures. with mivacurium 0.2 mg kg-1, the severity of liver disease did not correlate with duration of block compared with controls (time from bolus to t1 25%, p = 0.74; t1 25% to t4:t1 > 0.7, p = 0.545). however, initial reco ...	1998	9861140
effects of thyroidectomy and thyroxine replacement on seasonal reproduction in the red deer hind.	two experiments were conducted to test whether thyroid hormones are required for the cessation of the breeding season in female red deer. in expt 1, 16 mature hinds were allocated early in the breeding season (may) to the following groups: thyroidectomized (thx), thyroidectomized and treated with subcutaneous thyroxine implants which increased plasma tri-iodothyronine to physiological concentrations (thx + t4), or euthyroid controls. plasma progesterone concentrations consistent with oestrous cy ...	1998	9861164
gestational transient hyperthyroxinaemia (gth): screening for thyroid function in 23,163 pregnant women using dried blood spots.	transient elevation of serum free t4 (gestational transient hyperthyroxinaemia; gth) occurs occasionally during normal pregnancy, especially in early gestation. however, the frequency of gth and its clinical features remain unclear to date. the aim of this study was to determine the occurrence rate of gth and the relation between serum levels of hcg, free t4 (ft4), and tsh in a large number of pregnant women.	1998	9861323
laryngeal cancer in lower silesia: descriptive analysis of 501 cases.	this paper presents a descriptive analysis of 501 cases of laryngeal cancer. the patients were classified according to their age, sex, primary tumour localisation and stage. there were 448 males and 53 females, with a male-to-female ratio of 8.5:1. the peak incidence of cancer was detected in the 6th and 7th decades of age. the most common primary tumour localisation was the glottis. three-hundred-and-forty patients presented at advanced tumour stages (t3/t4). the proportion of patients presenti ...	1998	9861343
pharmacological effects of propylthiouracil on corticosterone secretion in male rats.	we investigated the direct effects of propylthiouracil (ptu) on corticosterone secretion both in vivo and in vitro.	1998	9861780
acute effects of chundosunbup qi-training on blood concentrations of tsh, calcitonin, pth and thyroid hormones in elderly subjects.	the present study investigated how the systemic treatment of a programmed exercise, chundosunbup (cdsb) qi-training, affects the secretion of thyroid and parathyroid hormones in elderly subjects (10 male and 5 female). plasma concentrations of thyroid stimulating hormone (tsh), triiodothyronine (t3), thyroxine (t4), parathyroid hormone (pth), ionized calcium, and calcitonin were determined. cdsb qi-training induces a slight increase in tsh. both t4 and t3 were increased at the mid-time of cdsb q ...	1998	9862015
staging of breast cancer: what standards should be used in research and clinical practice?	bone scan (bs), chest x-rays (cxr), liver ultrasonography (lus) and laboratory parameters (lp) are frequently used as routine staging procedures for breast cancer patients. these procedures are not always appropriate in either clinical or research settings, regardless of the stage. the aim of this study was to identify groups of patients with differing risks for metastases in order to select more precise standard staging procedures.	1998	9862046
gfp:hiv-1 protease production and packaging with a t4 phage expression-packaging processing system.	a bacteriophage t4-derived protein expression, packaging and processing system was used to create recombinant phage that encode, produce and package a protein composed of human hiv-1 protease fused to green fluorescent protein (gfp). the fusion protein is targeted within the phage capsid by an n-terminal capsid targeting sequence (cts), which is cleaved through proteolysis by the viral scaffold protease p21. the fusion protein is designated cts [symbol see text] gfp:pr. the [symbol see text] sym ...	1998	9863054
changes of peripheral tissue thyroid hormone metabolism in rats fed with selenium- and vitamin e-deficient artificial semisynthetic diet.	to examine the relationship between selenium (se)- and vitamin e(ve)-deficiency and thyroid hormone (th) metabolic disturbance, especially type i iodothyronine 5'-deiodinase (id-i) activity.	1998	11155682
iodine-induced hypothyroidism as a result of excessive intake of confectionery made with tangle weed, kombu, used as a low calorie food during a bulimic period in a patient with anorexia nervosa.	a 20-year-old japanese female anorectic patient developed primary hypothyroidism associated with generalized edema because of excessive daily intake (40 to 50 g) of confectionery made with tangle weed, kombu, which she substituted to food during bulimic periods; tsh 60.35 mcu/ml, free t3 1.19 pg/ml, and free t4 0.48 ng/dl, and her weight increased by 12 kg to 45 kg over 4 months. after withdrawal of kombu her thyroid function returned to normal, and her weight decreased by 7 kg to 38 kg along wi ...	1998	11234256
[the use of bi-pedical rotatory door muscle-skin flap reconstruction in extended partial laryngectomy for late (t3 and t4) glottic cancer].	the purpose is to radical treatment for late glottic cancer by surgery, to restore the essential function of the larynx, 62 patients of late (t3 and t4) glottic cancer were treated by extended vertical partial and subtotal laryngectomy. at the same time, an appropriate method of reconstruction of laryngeal function by bi-pedical rotatory door muscle-skin flap was presented. the decannulation rate was 87.1% and 85.0% cases enjoyed satisfactory voice. all cases resumed normal mouth-food-taking. th ...	1998	11263209
[speech reconstruction after laryngectomy by using modified pearson's operation].	since 1990, 16 patients received speech reconstruction after laryngectomy by using modified pearson's operation. among them, t3, t4 laryngeal cancer 12 cases, t4 hypopharyngeal cancer 4 case, 14 were male and 2 were female, the eldest was 73 years old and the youngest 51 years old, and the average age was 58 years. in the operation, the tracheo-pharyngeal speech tube were sewn up with mucosa remained at laryngopharynx. during 1-5 years follow up, the speech function and swallow function were sat ...	1998	11263212
early development of transient hypothyroidism after i131 therapy for thyrotoxicosis.	295 patients of graves' disease were studied for early development of transient hypothyroidism (th) and its prognostic value following i131 therapy. 278 patients received i131 < 10 mci (6.4 +/- 1.7 mci) and 17, a dose of > 10 mci (12.6 +/- 2.6). th was diagnosed on the basis of low t4 regardless of tsh within the first year after i131 therapy followed by normal t4 and tsh. 32 patients developed th following administration of < 10 mci i131 and it was symptomatic in 10 patients. no instance of th ...	1998	11273344
human slow cortical potential in association with voluntary jaw movements.	the distribution of a readiness potential (rp), i.e., a negative-going slow cortical potential (scp) preceding the onset of voluntary movements, was studied in association with self-paced voluntary jaw-closing and jaw-opening movements in 4 healthy human subjects. a negative-going scp starting at ca.1.5-2.0 s preceding the onset of the self-paced jaw-opening and jaw-closing movements was found at all the recorded sites of fz, cz, pz, f3, f4, f7, f8, c3, c4, t3 and t4. the rp was maximum in ampli ...	1998	11186211
napwa sends thrush alert. national association of people with aids.	the national association of people with aids (napwa) is warning people that drug-resistant strains of oral candidiasis (thrush) can be transmitted. the group recommends that people with greater than 200 t4 cell counts discontinue prophylactic treatment, and that people with thrush receive treatment as needed to minimize the chance of developing resistant strains.	1998	11364992
understanding and managing resistance.	as many as 25 to 45 percent of patients using triple therapy with protease inhibitors will develop resistance due to a change in the genetic hiv code. however, patients who develop resistance may still benefit clinically when protease inhibitors are used in combination with other antiretrovirals. these patients may not have undetectable viral loads although they may have stable t4-cell counts. resistance does not always lead to disease progression. newer drugs under development or available thro ...	1998	11364997
latest opportunistic infection prevention guidelines.	although people with hiv are living longer than ever before, they continue to suffer from infections that are associated with low t4-cell counts. the u.s. public health service (phs) and the infectious diseases society of america (idsa) have updated the guidelines for preventing opportunistic infections, including their positions on when prophylaxis is indicated. summaries are given for preventing the following infections: cytomegalovirus (cmv), cryptosporidiosis, fungal infections, human papill ...	1998	11365000
hydroxyurea for hiv?	the anticancer drug, hydroxyurea, can help certain anti-hiv drugs work better. hydroxyurea's side effects, dosage requirements, and method of reducing hiv in the body are discussed. results from several small studies of hydroxyurea indicate that the addition of hydroxyurea to ddi produces a stronger anti-hiv effect than ddi alone. hydroxyurea may also help to increase t4 cell counts. it is uncertain how hydroxyurea combined with ddi will work in patients with low t4 cell counts and more advanced ...	1998	11365419
good news about hiv treatments.	new and stronger anti-hiv treatments are decreasing aids mortality and opportunistic infections statistics. studies in baltimore, new orleans, and france showed significant drops in new cases of cytomegalovirus (cmv), mycobacterium avium complex (mac), kaposi's sarcoma, and pcp. drug side effects and drug adherence remain problematic. it appears that even a short-term reduction in viral load can produce long-term improvement in health and increase t4 cell count. researchers speculate that hiv is ...	1998	11365424
[effect of wulong dan on treatment of acute cerebral infarction and change of hormones in hypothalamus-pituitary-thyroid axis].	to explore the effect of wulong dan (wld) on treatment of acute cerebral infarction and change of hormones in hypothalamus-pituitary-thyroid axis.	1998	11367657
uveodermatological syndrome (vogt-koyanagi-harada-like syndrome) with generalized depigmentation in a dachshund.	a 3-year-old, female, black and tan dachshund was referred with visual impairment, bilateral anterior and posterior uveitis, poliosis, and generalized dermal depigmentation. complete blood counts and biochemical parameters, including t3 and t4, were normal. the skin biopsy showed lichenoid dermatoses with dermal infiltration of histiocytes and lymphocytes suggesting uveodermatological syndrome. medical treatment was initiated with oral prednisone and azathioprine, and topical prednisolone and at ...	1998	11397209
[verification and epidemiological study on endemic iodide-induced goiter in jiangsu old yellow river flooded plain].	to verify the existence and reveal the epidemiological characteristics of endemic iodide-induced goiter in jiangsu old yellow river flooded plain, 12 spots were selected in this survey. the results showed that the total goiter rate of 22.18% by palpation and 12.83% by b-ultrasound which surpassed the 5%-cutpoint-recommended jointly by who/unicef/iccidd. the urinary iodine median was 962 micrograms/l in 607 samples. the average 24 hours i31iodine-emissivity ratio was 4.6 +/- 0.3% with most of the ...	1998	10322720
comparison of assessment of fowl sperm viability by eosin-nigrosin and dual fluorescence (sybr-14/pi).	the kinetics of fowl sperm viability/mortality following short-term and long-term in vitro storage were studied using 2 different staining methods: eosin/nigrosin (observed under light microscopy) and sybr-14/pi (dual fluorescence). based on data obtained at 0, 30 min and at 2, 4 and 24 h (t0, t30, t2, t4, and t24) after in vitro storage (4 degrees c, agitated) of fresh or frozen-thawed semen, the dual association sybr-14/pi was more effective than eosin/nigrosin (p < 0.05) staining for the dete ...	1998	10732141
y-ligation: an efficient method for ligating single-stranded dnas and rnas with t4 rna ligase.	very efficient ligation of oligodeoxyribonucleotides was attained through a simple molecular construct, which is composed of one stem and two branches (y-shape), with use of t4 rna ligase. single-stranded dnas (naturally, rnas also) of more than 100 nucleotides (even 800 nts) were considerably ligated, approximately as theoretically expected. owing to the molecular construct adopted, such a tiny amount of ligation products could be amplified to a sufficient amount by pcr and then recovered as si ...	1998	10729904
[schistosoma japonicum ferritin: cloning, nucleotide sequencing, expression, and purification].	our previous work showed that immunization of mice with schistosoma japonicum (sj) immature eggs induced significant immunity against fecundity and embryonation of the parasite. the sj adult cdna library was screened by sera from rabbits against sj immature egg antigen (rasjiea). the genes encoding molecules which may induce immunity against fecundity/embryonation were chosen for further cloning and expression. first of all, rasjiea was absorbed with e. coli lysate to remove cross reactive antib ...	1998	10682550
[respiratory muscle function and serum enzymology in hyperthyroidism before and after treatment].	to investigate the effect of hyperthyroidism on respiratory muscle function and its possible mechanism, the thyroid function, serum enzymology, serum potassium, pulmonary function and respiratory muscle function were examined in 60 patients with grave's disease before treatment and 26 patients among them after treatment, and 20 normal subjects as control. t3, t4, and ft4 increased while fvc and pimax, which reflect the respiratory muscle strength, and pi/pimax, which reflects the reserve capacit ...	1998	10684017
thyroid hormones are involved in insulin-like growth factor-i (igf-i) production by stimulating hepatic growth hormone receptor (ghr) gene expression in the chicken.	effect of thyroid status on igf-i production in growing chickens was studied. serum concentrations of gh were not affected by propylthiouracil (ptu) or thyroxine (t4) treatments, whereas serum igf-i levels were significantly decreased in ptu-treated chickens. the lowered serum igf-i levels in the ptu-treated group were completely restored to the control levels by t4 injections. in the liver, the messenger rna (mrna) expressions both for gh receptor (ghr) and igf-i were significantly repressed by ...	1998	10984312
[application of pectoralis major myocutaneous flap in the reconstruction of tongue: an analysis of 86 cases].	to analyze the results of the use of pectoralis major myocutaneous (pmm) flap in the reconstruction of tongue.	1998	10920968
[supraglottic horizontal laryngectomy for supraglottic carcinoma].	to evaluate the therapeutic results of supraglottic horizontal laryngectomy (shl) for t1 and selected t2, t3 and t4 supraglottic carcinoma.	1998	10920989
[histopathological study of local invasiveness of transglottic cancer].	to explore the characteristics and relevant factors of transglottic cancer invading paraglottic space (pgs) and pre-epiglottic space (pes).	1998	10920990
[supraglottic laryngectomy with or without one arytenoid in epiglottic carcinoma. a report of 40 cases].	supraglottic laryngectomy with or without one arytenoid is a functional laryngectomy suitable for treatment of epiglottic squamous carcinoma. this procedure consists of resection of the thyroid cartilage, epiglottis and the entire preepiglottic space.	1998	10921017
interaction of methyl green with an oligonucleotide in intramolecular duplex and triplex conformations. circular dichroism studies.	interaction of methyl green with the oligonucleotide 5-dggaaaagg-[t4]-ggaaaagg-[t4]-ccttttcc (where [t4] is a nucleotide sequence of four thymines) in hairpin duplex and in intramolecular triplex structures has been studied by circular dichroism. we found that methyl green binding to the duplex form shows a complex pattern, exhibiting an exciton contribution when the number of bound molecules increases. differences between this pattern and previously published results on other dnas reveals the p ...	1998	10950636
quantitative analysis of motion control in long term microgravity.	in the frame of the 179-days euromir '95 space mission, two in-flight experiments have foreseen quantitative three-dimensional human movement analysis in microgravity. for this aim, a space qualified opto-electronic motion analyser based on passive markers has been installed onboard the russian space station mir and 8 in flight sessions have been performed. techhology and method for the collection of kinematics data are described, evaluating the accuracy in three-dimensional marker localisation. ...	1998	11541920
hormonal adaptation to real and simulated microgravity.	the authors provide an overview of relevant results from endocrine studies in astronauts before, during, and after space flight. the hormonal systems examined are the water-electrolyte regulation, the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary gonadal axis, the growth hormone-insulin like growth factor 1-prolactin system, hormones which affect bone turnover, the hypothalamic-pituitary-thyroid axis, and the endocrine pancreas. hormones studied include renin, aldosterone, vaso ...	1998	11542377
[not available].	the euthanasia action in nazi germany during 1940/41 ("aktion t4") belongs to the most horrible chapters in history of medicine. the article describes the life of horst schumann, who was involved in the murder of more than 15 000 people and after that did cruel sterilization experiments in auschwitz. it will be depicted the personal characteristics to show, why he was susceptible to this development. the critical look at these events shall warn us not to push away mental patients and mentally ha ...	1998	11619921
[evaluation of magnetic resonance imaging in staging of laryngeal cancer].	to evaluate the value of the preoperative t staging of laryngeal cancer by mri.	1998	11717894
[the extended indications of near-total laryngectomy].	to evaluate near-total laryngectomy in treatment of laryngeal cancers.	1998	11717912
ru(phen)(2)dppz(2+) luminescence: dependence on dna sequences and groove-binding agents.	emission of delta-ru(phen)(2)dppz(2+) bound to nucleic acid polymers of different sequence has been investigated by time-resolved luminescence spectroscopy and the effect of major and minor groove dna binding agents on the luminescence profile of the complex evaluated. in the presence of a 1:1 mixture of poly d(at) and poly d(gc), the excited-state decay of delta-ru(phen)(2)dppz(2+) can be described by a linear combination of the decay profiles in the presence of poly d(at) and poly d(gc) indepe ...	1998	11670256
[preoperative radiation plus surgery vs. operation alone for laryngeal carcinoma].	to study the validity of preoperative radiation in improving the survival rate of laryngocarcinoma.	1998	11938852
[kinetic effect of testosterone or estradiol on iodine absorption in castrating rat intestine].	to observe the effect of testosterone or estradiol on iodine absorption in rat intestine.	1998	11939028
effects of super-extended paraaortic lymphadenectomy (pal) on biological responses in totally gastrectomized patients with t3 or t4 gastric cancer.	background: in japan, much attention has recently been paid to super-extended paraaortic lymphadenectomy (pal) for the treatment of advanced gastric cancer. however, it has been reported that pal is associated with increased morbidity and mortality, as compared to conventional extended lymphadenectomy (d2 or d3). therefore, an analysis of the effects of pal on perioperative changes in the biological responses of patients essential for determining the potential utility of this procedure.methods: ...	1998	11957044
the effect of fasting and refeeding on thyroid follicule structure and thyroid hormone levels in young and old rats.	in order to assess morphological and functional plasticity of the thyroid gland in aging the effects of fasting and refeeding on the thyroid morphology and thyroid hormone serum levels were compared with morphometry and ria in young and old rats. young (4 months) and old (24 months) male wistar rats were fasted for 40 h and sampled, or fasted and fed thereafter for 4 or 24 h. in control (fed) old animals the thyroid follicules were larger, the follicular epithelium was smaller and colloid resorp ...	1998	18653134
different co2 levels during incubation interact with hatching time and ascites susceptibility in two broiler lines selected for different growth rate.	embryos from ascites sensitive (as) and resistant lines (ar) were subjected during the third week of incubation to a high co2 (0.4%) (hc) or normal co2 level of 0.2% (nc) in the incubators. the effect on embryonic and hatching parameters and growth, ascites sensitivity and related physiological parameters was followed. at nc conditions ar embryos hatch earlier than as ones but this difference completely disappeared under hc condition, since hatching time of the as line was reduced. moreover, as ...	1998	18484049
ideology and ethics. the perversion of german psychiatrists' ethics by the ideology of national socialism.	as soon as adolf hitler came to into power in 1933, four laws on racial segregation and race protection were edicted between 1934 and 1935. schizophrenia, manic-depressive psychoses, epilepsy and alcoholism were regarded as hereditary mental illnesses. these laws were responsible for the sterilisation of 350,000 individuals who were thought to be at the source of the propagation of hereditary illnesses which might endanger the health and the future of the aryan germans. on september 1, 1939, act ...	1998	19698678
effect of thyroid hormones onflavin-containing monooxygenase activity in co-cultured adult rat hepatocytes.	the regulation of flavin-containing monooxygenase (fmo) by thyroid hormones was examined under well defined in vitro conditions using adult male rat hepatocytes co-cultured with rat liver epithelial cells of primitive biliary origin. serum free medium was used to avoid interferences from foetal bovine serum. the effect of thyroxine (t4) and its major metabolite l-triiodothyronine (t3) on fmo activity was estimated spectrophotometrically by measuring the rate of methimazole oxygenation. the highe ...	1998	20654415
modulating effects of thyroid state on the induction of biotransformation enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	in this study we investigated to what extent the induction of detoxification enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is modulated by concomitant tcdd-induced changes in thyroid state. euthyroid (eu) male sprague-dawley rats, surgically thyroidectomized (tx) rats and tx rats receiving substitution doses of 3,3',5-triiodothyronine (tx+t3) or thyroxine (tx+t4) by osmotic minipumps were treated with a single ip injection of 10 ++g tcdd/kg/bwt or with vehicle (corn oil). three days afte ...	1998	21781845
epidural lidocaine for cesarean delivery of the distressed fetus.	lidocaine with epinephrine and sodium bicarbonate has a rapid onset of action. we therefore wished to compare its use with that of chloroprocaine for urgent cesarean delivery. thirty parturients for cesarean section under epidural anesthesia were divided into three groups. group 1 required elective cesarean section and served as the control group for neonatal lidocaine levels. groups 2 and 3 had been receiving epidural infusions of 0.125% bupivacaine with epinephrine 1:400,000 and required urgen ...	1998	15321243
pathological findings in dyshormonogenetic goiter with defective iodide transport.	an adult male patient (38 yr old) with a large congenital goiter with hypothyroidism was suspected of having a defective iodide (l) transport mechanism based on low thyroid uptake and a very low salivary/plasma ratio. moreover the high serum levels of tsh (104 uu/ml) declined to 7.2 uu/ml with a corresponding normalization of serum total t4 concentration, after 40 d of treatment with lugolts solution (6 mg l/d). thyroid surgery was performed because a fine-needle aspiration biopsy of a nodule re ...	1998	12114713
[cloning and sequence analysis of the gene encoding the partial region cs protein of a plasmodium falciparum isolate from yunnan].	determining nucleotide sequence of the circumsporozoite protein partial gene of the plasmodium falciparum pfd-3/yn (yunnan of china) and finding out the differences of the cs gene sequence between chinese plasmodium falciparum isolate and other isolates.	1998	12078270
tnf alpha released in the early post-operative period is influenced by anaesthesia.	in this study we tested for tnf alpha concentrations 45 subjects undergoing elective prostatectomy performed under two different anaesthetic regimens. in addition, given the influence of neuroendocrine axis on immunological homeostasis, we also determined post surgery cortisol and norepinephrine levels. the patients were randomly assigned to one of two groups: group 1 (no. = 24) received nla general anaesthesia, whereas group 2 (no. = 21) received spinal analgesia. blood samples were drawn the d ...	1998	11995034
prevalence of chronic lymphocytic thyroiditis in adolescent girls.	chronic lymphocytic thyroiditis (clt) is the most common cause of thyroid enlargement in children and adolescents in iodine sufficient areas. the prevalence and pattern of clt in adolescent girls in iodine deficient regions supplemented with iodine is as yet not known. we therefore, carried out clinical examination for the presence of goitre in 330 healthy girls from delhi in the age group of 16-20 years and those with goitre were further subjected to detailed biochemical (t3, t4, tsh), immunolo ...	1998	12152841
[cloning and sequencing of fusion protein gene of recombinant gm-hbsag].	gm-csf is an effective adjuvant for immunology, it was used to improve the immunological function of antigen and to increase the anti-hbs responses. through using polymerase chain reaction (pcr) technique, we amplified 384 bp and 846 bp gene fragments from gm-csf and hbsag. the products were extracted and purified; a 1230 bp gene fragment was obtained by t4 dna linkage. this amplified product was cloned into puc19 vector. the positive clones were screened and the inserted fragment was determined ...	1998	12526340
[study on behavior of thyroid gland hormones in bydgoszcz province children and teenagers with simplex struma].	struma caused by iodine deficit is an endemic disorder in specified regions. the purpose of the study was a biochemical characteristic of struma simplex in children from bydgoszcz province and evalued correlation between laboratory exponents of thyroid gland function, size of the gland and kind of the struma. it was confirmed that neutral struma of children generally takes a course with euthyroidism. in children with struma were confirmed significant lower values of t4 and no significant higher ...	1998	12818108
[the thyroid function in children with viral meningitis].	thyroid function was investigated in children affected with viral meningitis caused by mumpsvirus or enteroviruses. serum or plasma levels of thyroid-stimulating hormone (tsh), triiodothyronine (t3), free triiodothyronine (ft3), thyroxine (t4) and free thyroxine (ft4) were measured twice in course of the disease: at admission and at recovery (day 10-14 from the onset of illness). the levels of hormones were measured by radioimmunoassay (ria) or by enzyme linked fluorescent assay (elfa). a decrea ...	1998	12818109
[the thyroid function in children with purulent meningitis].	purulent meningitis (bm) is a complex process and its outcome is largely influenced by host's response, both inflammatory or endocrine, to the infection. in this study thyroid function in children with bm was investigated by measuring serum or plasma levels of thyroid-stimulating hormone (tsh), triiodothyronine (t3), free triiodothyronine (ft3), thyroxine (t4) and free thyroxine (ft4) 3 times in course of the disease: at admission, after 24-48 hrs. of treatment and at recovery (day 10-14 from th ...	1998	12818110
recent information on iodine deficiency in new zealand sheep flocks.	to determine the value of pasture iodine, serum thyroxine (t4) and tri-iodothyronine (t3) concentrations and thyroid (g) to body weight (kg) ratios in lambs as criteria to predict and diagnose increased litter size and decreased perinatal mortality in response to iodine supplementation.	1998	16032052
electrophoresis of long dna molecules in linear polyacrylamide solutions.	electrophoresis of long dna (t4 dna; 166 kb, s. pombe chromosomal dna; 3-6 mb) in linear polyacrylamide solutions was investigated by fluorescence microscopy and capillary electrophoresis. in the past studies on electrophoresis of long dna in a polymer solution, it was reported that dna migrates in 'u-shape conformation'. we found that at higher polymer concentrations, the shape of the migrating dna changes from u shape to linear shape ('i-shape conformation'). in the migration mode with the i-s ...	1998	17029695
[effect of ginseng injection in treating congestive heart failure and its influence on thyroid hormones].	to observe the effect of ginseng injection on congestive heart failure (chf) and its influence on thyroid hormones.	1999	11783267
[expression of antisense telomerase genes suppressing human cancer malignant phenotypes].	altering the expression of telomerase genes htrt and htr to induce changes in cancer cell biology and to determine their value in cancer gene therapy.	1999	11869549
results of resting and ambulatory electrocardiograms in patients with hypothyroidism and after return to euthyroid status.	hypothyroidism is not infrequently associated with an abnormally long qtc interval (> or = 450 msec). rarely, marked prolongation of the qtc interval and malignant ventricular arrhythmias have been reported. in this study, qtc intervals on resting electrocardiograms (ecgs) were compared in 10 patients before and after treatment of hypothyroidism. the qtc interval increased in seven patients during euthyroidism compared with hypothyroidism, and decreased in three patients. during hypothyroidism, ...	1999	11720599
synthesis of infectious viroids and other circular rnas.	viroids are small autonomously replicating rnas that share structural features with other subviral circular single-stranded rnas of plants. viroids and other circular single-stranded rnas can be synthesised in vitro by a pcr-based procedure using a simple set of reactions. two end-to-end primers are selected from a desired region of the viroid, one for the synthesis of the first strand cdna and another for the production of the second strand dna. the second primer contains an 18 nucleotide t7 pr ...	1999	11475697
factors involved in the neuronal death during postischemic reperfusion: experimental study in rabbits.	to explore the main pathogenic factors in the development of neuronal death during normothermic reperfusion in rabbits.	1999	11593584
influence of hypovolemic and hypertonic treatments on plasma vasopressin levels and fluid balance in the propylthiouracil-induced hypothyroid rat.	this study was undertaken to investigate the effects of hypovolemic and hypertonic treatments on plasma vasopressin (avp) levels and fluid balance in propylthiouracil (ptu)-induced hypothyroidism in the rat. the influence of hypothyroidism on avp responsiveness to hypertonic and hypovolemic stimuli were compared. adult male rats were divided into two groups. groups i and ii were intraperitoneally (i.p.) injected with saline (1ml/250g) and ptu (10mg/kg/day), respectively, for a period of two week ...	1999	11460093
effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture.	to observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture.	1999	10921139