Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| antibodies to the acetylcholine receptor in myasthenic dogs. | antibodies to the achr and anti-striational antibodies have been detected in dogs suffering from myasthenia gravis. the detection of these antibodies adds to the known similarities between the human and canine disease. this animal model will facilitate investigation of agents involved in the induction of spontaneous myasthenia gravis. | 1979 | 500127 |
| lymphocyte adherence in multiple sclerosis. | it has been reported that peripheral blood lymphocytes from patients with multiple sclerosis (ms) adhere to measles-infected human epithelial cells in significantly greater numbers than do lymphocytes from healthy volunteers or patients with other neurologic diseases. we have confirmed this observation in three separate studies, and have investigated the relationship of lymphocyte adherence to the clinical state. lymphocyte adherence determination values correlated with the degree of certainty o ... | 1979 | 571067 |
| persistent measles virus infection in a calf kidney cell line. note iii. cellular alterations in the selected chronically infected k-2 cell line. | marked morphological, growth and chromosome alterations pointing to in vitro cellular transformation were made evident in a selected calf kidney cell line (k-2) chronically infected with measles virus. the transformed cell line released infectant virus and had no oncogenic potential for the hamster. | 1979 | 575453 |
| subacute sclerosing panencephalitis after drug-induced immunosuppression. | a girl developed subacute sclerosing panencephalitis (sspe). eight years earlier she had had measles infection contracted shortly after cytotoxic treatment and radiotherapy for a spinal neuroblastoma. the case illustrates that typical sspe, like immunosuppressive measles encephalopathy, can arise after drug-induced immunosuppression, and supports the view that these diseases probably represent opposite ends of a spectrum induced by measles virus infection in an individual with some form of immun ... | 1979 | 507919 |
| [experimental model for studies on viral encephalitis (author's transl)]. | 1979 | 507949 | |
| measles virus-specified polypeptide synthesis in two persistently infected hela cell lines. | measles virus-directed protein synthesis was examined in two hela cell lines (k11 and k11a) that are persistently infected with wild-type measles virus. four viral proteins (h, hemagglutination protein; p, nucleocapsid-associated protein; np, the major nucleocapsid protein; and m, the matrix protein) were readily detected in both cell lines by immune precipitation of [(35)s]methionine-labeled cell extracts followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. when analyzed by so ... | 1979 | 513191 |
| measles sero-immunity in rural non-vaccinated children of busoga district, uganda. | 1979 | 520246 | |
| modulation of the adherence of human lymphocytes to measles-infected cells by prostaglandin e1: a differential effect on lymphocyte subpopulations. | prostaglandins of the e series (pge) may serve as important regulators of human immune responsiveness. the present study was designed to examine the possibility that pge may effect human lymphocyte function by the modulation of surface receptors. the presence of surface binding sites on human lymphocytes for measles virus antigens was studied using a rosette adherence assay. we observed that the addition of pge1 increased the proportion of measles-infected cells (hela-kll) with adherent lymphocy ... | 1979 | 523674 |
| [neurological complications following measles virus vaccination. evaluation of the cases seen between 1971--1977 (author's transl)]. | within 11 days following vaccination with live virus vaccine in hamburg 18 cases of neurological complications have been observed between 1971--1977, including 2 cases of abortive encephalitis. a causal connection was assumed only when the onset of symptoms was later than on the 7th day after the vaccination. the following parameters were evaluated; clinical symptoms, laboratory data, seasonal distribution of the neurological complications and their relationship to the total number of vaccinatio ... | 1979 | 759838 |
| lymphocyte adherence in multiple sclerosis: effect of aspirin. | peripheral blood lymphocytes from multiple sclerosis (ms) patients form substantially greater numbers of rosettes with measles virus-infected human epithelial cells than do lymphocytes from healthy controls or from patients with other diseases. we have previously shown that prostaglandin e(1)-treated normal lymphocytes exhibit increased lymphocyte adherence, and thus behave like ms lymphocytes in this in vitro system. in this study we describe the effect of prostaglandin synthesis inhibition on ... | 1979 | 762244 |
| physical map of the dna genome of autographa californica nuclear polyhedrosis virus. | a physical map of the 88 x 10(6) dalton, circular dna genome of autographa californica nuclear polyhedrosis virus was constructed. the complete order of bamhi and xmai restriction enzyme sites was determined. the ecori and hindiii fragments were partially ordered, and their general locations, relative to the bamhi and xmai maps, were determined. alterations in the restriction endonuclease fragment patterns of natural genotypic variants of a. californica nuclear polyhedrosis virus, including tric ... | 1979 | 16789175 |
| studies on the synthesis of basic proteins and antigenic components in measles virus infected cells. | the synthesis of histone f1 fraction in synchronous culture of (3h)-l-lysine labeled hela cells was inhibited 30 to 45 hours earlier and to a higher degree after infection with attenuated l-16 strain of the measles virus than after infection with laboratory edmonston strain. dithiothreitol and triton x-100 were used to isolate a cytoplasmatic component (k-2c) lacking infectivity but associated with hemagglutinating activity, from both strains. the component from both strain induced the synthesis ... | 1980 | 19852113 |
| live attenuated measles vaccine. | this article reviews the history of measles vaccine development. such a review is considered useful for understanding the relationship of the different brands of live attenuated measles vaccine available. in 1954, the measles virus was isolated from an 11-year old boy from the us, david edmonston, and adapted and propagated on chick embryo tissue culture (ce). the ce adapted strain, known as edmonston a, was too virulent for vaccine purposes. the strain was attenuated by means of further pas ... | 1980 | 12314356 |
| search for canine-distemper-virus antibodies in multiple sclerosis. a detailed virological evaluation. | sera and cerebrospinal fluid samples from multiple-sclerosis (ms) patients, matched controls, and subacute sclerosing panencephalitis (sspe) patients were analysed for the presence of antibodies specific for measles and canine distemper virus (cdv). virus-specific antibodies were identified by haemagglutination inhibition, neutralisation, and immune precipitation in combination with polyacrylamide-gel electrophoresis. sspe and ms patients had a higher antibody activity towards measles virus than ... | 1980 | 6107454 |
| transfer factor in treatment of multiple sclerosis. | a 2-year prospective double-blind trial of the treatment of multiple sclerosis patients with the leucocyte extract, transfer factor (tf), obtained from leucocytes of relatives living with the patient, was conducted. 60 patients with definite ms, of whom 58 completed the trial, were divided into two equal groups, one of which received tf and the other placebo. the groups were evenly balanced with respect to sex ratios, disability, duration of disease, ratio of moderate to severe cases, and hla ph ... | 1980 | 6107585 |
| viral antigens in osteoclasts from paget's disease of bone. | osteoclasts from patients with paget's disease of bone contained viral antigenic material. ultrastructural and immunological studies suggested that measles or measles-related virus was the agent involved. | 1980 | 6105480 |
| peculiarities of the virus-host cell relationship in a calf kidney cell line persistently infected with measles virus. | persistent infection with measles virus established in a calf kidney cell line differed in some features from other measles virus carrier systems. after a variable life span, ranging from 50 to 1100 days, six of the chronically infected cell lines showed an evolution towards lytic infection. only one of these lines, the k-2 cell line, exhibited marked morphological, growth and chromosomal alterations suggesting in vitro cellular transformation. the transformed k-2 cells released infectious measl ... | 1980 | 6106376 |
| investigation on the role of viral antibodies in the pathogenesis of multiple sclerosis. | an attempt was made to elucidate the role of antibodies to measles, rubella and mumps viruses in the pathogenesis of multiple sclerosis by correlating their levels in the blood of patients with clinical manifestations of the disease. antibody titres to measles and rubella viruses were higher during exacerbations of the process and decreased during remissions. no correlation was found between the level of viral antibodies and the duration of the disease, features of its course (rapidly or slowly ... | 1980 | 6111202 |
| [index of damage to neutrophils by gamma-globulin in rheumatic diseases]. | 1980 | 6163895 | |
| isoprinosine treatment in 18 patients with subacute sclerosing panencephalitis: a controlled study. | isoprinosine (inosiplex), a proposed antiviral agent, was given to 18 patients with subacute sclerosing panencephalitis (sspe). no great improvement occurred in any patient soon after treatment, but 2 patients did improve substantially several months after discontinuing isoprinosine. spontaneous improvement also occurred in 4 out of 96 controls. because of the variable natural history of sspe, differences in clinical improvement between treated patients and controls were not significant. changes ... | 1980 | 6154441 |
| anesthetic action and virus replication: inhibition of measles virus replication in cells exposed to halothane. | replication of measles virus in bsc cells was studied in the presence of halothane, a commonly used volatile anesthetic. at clinical concentrations of the anesthetic, appearance of progeny virus was decreased in a dose-related manner. this inhibition was reversible as the removal of halothane allowed virus replication to be resumed. studies attempting to elucidate the mechanism of action of the anesthetic inhibition of virus replication revealed that halothane did not directly inactivate the vir ... | 1980 | 6156646 |
| monospecific antibody to the haemagglutinin of measles virus. | a hybrid between a murine myeloma cell line and spleen cells from a mouse immunized with measles has been produced. two stable clones produce antibody with identical immunochemical and biological properties. this antibody reacts with the 76,000 mol. wt. protein present in the lysates and on the surface of cells persistently infected with measles. it exhibits hai and neutralizing activity. | 1980 | 6156998 |
| membrane and cytoplasmic changes in virus-infected cells induced by interactions of antiviral antibody with surface viral antigen. | 1980 | 6158744 | |
| [antigen-containing bone marrow cells of mice immunized with a number of antiviral vaccines]. | virus-specific antigens in bone marrow cells of mice were investigated after inoculation of the animals with a set of live antiviral vaccines: poliovaccine type ii, vaccinia, measles vaccine, and poliovaccine again sequentially at 14-day intervals, and after individual use of the same vaccines. the results indicate that the specific antigens of the viruses used for preparation of the vaccines under study could be detected in bone marrow cells of mice for quite long periods of time: vaccina virus ... | 1980 | 6158797 |
| immunological relationships between homologous structural polypeptides of measles and canine distemper virus. | the major structural polypeptides of measles and canine distemper virus (cdv) were isolated by sds-polyacrylamide slab gel electrophoresis. rabbit hyperimmune sera directed against the isolated ha, p, np, f and m polypeptides were prepared. in addition, rabbit hyperimmune sera directed against purified native internal components of measles virus and against purified virions of measles and cdv, untreated or treated with trypsin, were prepared. these sera were used to study the immunological relat ... | 1980 | 6161986 |
| cell-mediated immune reactions in measles. | cell-mediated reactions in measles cases, in direct contacts and healthy children were tested. indices of phytohaemagglutinin-stimulated blastic transformation and leukocyte migration inhibition were evaluated. positive reactions were found in the first and second weeks after manifestation of clinical symptoms. the application of glucocorticosteroids in clinical complications resulted in delayed and reduced leukocyte migration inhibition. studies on seronegative contacts suggested that positive ... | 1980 | 6107020 |
| [studies on establishment and maintenance of persistent infection with measles virus in nc-37 cell. iii. role of interferon in establishment and maintenance of persistent infection (author's transl)]. | human lymphoblastoid cell, nc-37, persistently infected with measles virus could always produce interferon in culture medium. persistently infected cells were sensitive to interferon and acquired antiviral state, but normally yielded infectious progeny virus in culture fluid. sensitivity of measles virus to interferon was studied because measles virus continued to replicate in these persistently infected cell. attenuated and sspe viruses which established persistent infection were relatively res ... | 1980 | 6168552 |
| csf antibody to myelin basic protein. measurement in patients with multiple sclerosis and subacute sclerosing panencephalitis. | a solid phase radioimmunoassay was used to detect antibodies to myelin basic protein (mbp) in the csf of patients with multiple sclerosis (ms) and subacute sclerosing panencephalitis (sspe). f(ab')2 fragments prepared from sspe igg retained their activity, which showed that the assay measures a true antigen-antibody reaction rather than nonspecific adherence to igg to mbp. samples of csf from 48 patients with ms and 30 patients with sspe were tested and, in both conditions, antibody activity was ... | 1980 | 6153890 |
| prevalence of measles antibodies in patients with subacute sclerosing panencephalitis in poland in the years 1971--1978. | between 1971 and 1978, clinical centres in four provinces of poland reported 107 cases of subacute sclerosing panencephalitis (sspe). this series comprised 73.8% boys and 26.2% girls. most children were aged 6--8 years, and 66% of them had had measles in the first two years of life. as compared with a control group the geometric means of the haemagglutination-inhibiting antibodies and neutralizing antibodies were between ten and twenty times higher in sspe patients. determinations of the levels ... | 1980 | 6160218 |
| immunity to measles in malnourished children. | 1980 | 6161724 | |
| local immunity in mumps meningitis. | titers of antibodies to mumps and measles virus and interferon activity were measured in sera and csf obtained from 15 children with mumps meningitis. antibody to mumps virus was found in 11 of 15 csf samples. evaluation of the csf-serum ratio for antibodies to both viruses showed a substantially higher ratio for antibody to mumps virus. the ratio of igg/igm antibody activity to mumps virus was greater in csf than in sera. these results could be attributed to antibody synthesis, particularly igg ... | 1980 | 6159784 |
| interaction of polyriboinosinic acid, polyribocytidylic acid with human lymphoblastoid cells. | 1980 | 6244818 | |
| [studies on establishment and maintenance of persistent infection with measles virus in nc-37 cell. ii. effect of dna-synthesis-suppressing factor (dsf) on the production of interferon in nc-37 cell infected with measles virus (author's transl)]. | the attenuated strain of measles viruses, schwarz, cam-70, or subacute sclerosing panencephalitis (sspe) virus of measles viruses, halle, mantooth was good interferon inducer, but the virulent strain, edmonston, toyoshima induced few amount of interferon or not. furthermore, an inverse relationship seemed to exist between the ability to induce interferon and dna synthesis suppressing factor (dsf). the attenuated strain or sspe virus which had not a capacity to produce dsf could induce interferon ... | 1980 | 6165664 |
| hemagglutination by canine parvovirus: serologic studies and diagnostic applications. | conditions for canine parvoviral hemagglutination (ha) and hemagglutination-inhibition (hi) reactions were defined. the ha phenomena were used to differentiate canine parvovirus (cpv) from feline panleukopenia virus (fpv), mink enteritis virus (mev), and minute virus of canines. serologic comparisons of the cpv, fpv, and mev by ha-hi and serum-neutralization tests indicated that cpv, fpv, and mev were antigenically similar but were different from minute virus of canines. diagnostic application o ... | 1980 | 6250432 |
| ["pharaoh" line culture of japanese quail cells as a leukosis-free system for virus reproduction]. | contamination of japanese quail, strain pharaoh, cell culture with oncogenous and infectious avian viruses was studied. the susceptibility of the embryonal cell cultures of the japanese quail, strain pharaoh, to measles, parotitis and fixed rabies viruses was also determined. it was found that the sera of pubertal quails had no antibody to rous sarcoma virus (rsv), strains brian, rsv (rav-1), schmidt-ruppin, carr-zilber, as well as to marek's disease and newcastle disease viruses. no reverse tra ... | 1980 | 6251636 |
| [results of a protocol for etiologic diagnosis of pneumopathies on immunosuppressed children (author's transl)]. | a protocol for etiologic diagnosis has been used on 40 immuno suppressed children with pulmonary infiltrate. the purpose of this protocol is to permit an early etiologic diagnosis, concomitant infections by several pathogen agents being frequently seen. an endobronchial brushing is first performed; the results being obtained between 24 to 48 hours. if the results are negative and the patient's condition worsens we propose an open lung biopsy. thus pathogenic agent has been established in 24 case ... | 1980 | 6252614 |
| [antibodies to rubella virus in the blood sera and in the synovial fluid of children with rheumatoid arthritis]. | sera and synovial fluids from children with rheumatoid arthritis (ra) were examined for antibody to some viral and mycoplasmal antigens. blood sera from the patients were found to have a selective excess of antibody to rubella virus as compared with the age norm. antibody of this specificity was found in synovial fluids in titers significantly higher than those in the blood. titers of other antibodies in the synovial fluids were, as a rule, slightly lower than in sera. in the time course of inte ... | 1980 | 6252699 |
| comprehensive viral immunology of multiple sclerosis. ii. analysis of serum and csf antibodies by standard serologic methods. | sera and csfs of 85 patients with multiple sclerosis (ms), 49 patients with probable ms, and 165 control patients with other neurologic diseases were assayed for antibodies to rubella, mumps, measles, parainfluenza i (strain 6/94), herpes simplex, cytomegalovirus, varicella-zoster, and vaccinia viruses. methods included complement fixation (cf), hemagglutination inhibition (hi), and complement-dependent plaque reduction (cpr). significant differences between the groups with ms and the control gr ... | 1980 | 6252874 |
| comprehensive viral immunology of multiple sclerosis. iii. analysis of csf antibodies by radioimmunoassay. | the csf from 279 patients with multiple sclerosis (ms), probable ms, or controls was examined by radioimmunoassay (ria) for antibodies to measles, rubella, mumps, parainfluenza 1 (sendai) (strain 6/94), herpes simplex (hsv), varicella, and vaccinia viruses. significantly more patients with ms than noninflammatory control patients had antibody to measles, rubella and varicella viruses, of which antibody to measles was the most prevalent. the percentage of patients with ms with two or more csf ant ... | 1980 | 6252875 |
| inhibition of measles virus replication by cyclic amp. | 1980 | 6254254 | |
| viral and bacterial antibody responses in multiple sclerosis. | an imprint electroimmunofixation method (ieif) was used to characterize antibodies to eight viral antigens (measles, mumps, rubella, herpes simplex type 1, varicella-zoster, vaccinia, cytomegalovirus, adenovirus) and four bacterial antigens (beta-hemolytic streptococcus, hemophilus influenzae type b, escherichia coli, enterococcus) in serum and cerebrospinal fluid (csf) of 12 patients with multiple sclerosis (ms). twelve patients matched for age and sex sex served as controls. evidence for intra ... | 1980 | 6254433 |
| fluorometric assay for measurement of viral neuraminidase--application to the rapid detection of influenza virus in nasal wash specimens. | a sensitive assay was developed for the measurement of neuraminidase with use of the 4-methylumbelliferkyl-alph-ketoside of n-acetyl-neuraminic acid as a fluorescent substrate. neuraminidase activity was detected in preparation containing small quantities of cultivated influenza virus as well as in some nasal wash specimens from human volunteers experimentally infected with influenza a/alaska/78 virus. activity due to influenza viral neuraminidase could be distinguished from activity due to bact ... | 1980 | 6255042 |
| selective inhibition of herpes simplex virus glycoprotein synthesis by a benz-amidinohydrazone derivative. | 1h-benz[f]indene-1.3(2h)dione-bis-amidinohydrazone (benzhydrazone) inhibited incorporation of 14c-glucosamine, 14c-fucose and 14c-mannose into glycoproteins of hep-2 cells infected with various strains of herpes simplex virus 1 (hsv-1) and impaired rna and protein synthesis to a low extent. these biochemical effects are very similar to those induced by glycosylation inhibitors such as tunicamycin, d-glucosamine and 2-deoxy-d-glucose. in contrast to these inhibitors, benzhydrazone reduced hsv gly ... | 1980 | 6255895 |
| aspects of specific immunity. | 1980 | 6259719 | |
| comparison of direct immunofluorescent staining of clinical specimens for respiratory virus antigens with conventional isolation techniques. | staining of clinical respiratory specimens obtained by nasopharyngeal and throat swabs with direct fluorescein isothiocyanate-conjugated antisera to para-influenza virus types 1, 2, and 3, influenza a virus, respiratory syncytial virus, adenovirus, mumps virus, and measles virus was compared with isolation procedures in routine tissue culture systems. direct staining of clinical specimens with the commercially available conjugated offered a rapid means of diagnosing respiratory infections on a r ... | 1980 | 6260834 |
| [specificity of the resistance exhibited by peritoneal macrophages of rats immunized against rubeola virus]. | peritoneal macrophages in rats with no immunization against rubella virus and inoculted with bovine infectious rhinotracheitis virus are prone to suffer from a cytopathogenic effect with formation of inclusion bodies, and lysis, succeeding in reisolating the virus. the resistance of peritoneal macrophages of rats inoculated against rubella virus in nonspecific, since such resistance continues to show when macrophages interact with bovine infectious rhinotracheitis virus. the results support evid ... | 1980 | 6264551 |
| interferon production and virus replication in lymphoblastoid cells infected with different viruses. | a semicontinuous infection system was used to test viral replication and interferon induction in lymphoblastoid cells: measles virus, newcastle disease virus (ndv), sendai virus, human parainfluenza virus (type ii and iii), semliki forest virus (sfv) and vesicular stomatitis virus (vsv). with the exception of sendai virus, all viruses replicated in the namalva cell line. only measles virus was able to induce high levels of interferon. three other cell lines, nc37, raji (tk+-variant) and raji (tk ... | 1980 | 6243928 |
| the effect of fatty acid addition in vitro on direct migration inhibition with paramyxoviral antigens. | 1980 | 6249530 | |
| killing of virus-infected cells by cytotoxic lymphocytes. | 1980 | 6249872 | |
| cloning of dna complementary to the measles virus mrna encoding nucleocapsid protein. | double-stranded cdna synthesized from total poly(a)-containing mrna, extracted from monkey cells infected with measles virus, has been inserted into pst cleavage site of escherichia coli plasmid pbr322 and cloned. a clone containing measles virus dna sequences was identified by hybridization to a measles virus-specific 32p-labeled cdna probe prepared from the mrna of measles virus-infected cells. cellular sequences in the probe were neutralized by prehybridization with an excess of unlabeled mrn ... | 1980 | 6251476 |
| virus-induced decrease of insulin receptors in cultured human cells. | viral infections may produce abnormalities in carbohydrate metabolism in normal subjects and profound changes in glucose homeostasis in insulin-dependent diabetics. using an in vitro radio-receptor assay with 125i-labeled insulin and human-amnion (wish) cells, the effect of viral infections on insulin receptors was examined. both herpes simplex virus and vesicular stomatitis virus produced a 50% decrease in insulin binding. there was no evidence that this decrease was due to degradation of insul ... | 1980 | 6253524 |
| virus exposure diminishes beta-adrenergic response in human leukocytes. | we used ficoll-hypaque isolated peripheral lymphocytes and pmns to investigate the relationship between viral exposure and beta-adrenergic responses in target cells. lymphocyte e-rosette formation with sheep red blood cells and pmn beta-glucuronidase release in response to opsonized zymosan particles are two cell activities regulated by beta-adrenergic agonists. after incubation with influenza or measles virus, the treated cells have decreased response to isoproterenol, a beta-adrenergic agonist ... | 1980 | 6265987 |
| further epidemiological investigations on subacute sclerosing panencephalitis (sspe) in romania. | the epidemiological study of 101 sspe cases revealed the following aspects: a) an increase in the annual sspe incidence, in relation to the improvement of detection possibilities; b) the preponderent involvement of male children and of children having experienced measles within the first 6-18 months of life; c) the high incidence of sspe cases in families with several children, the patient being the 2nd or 3rd sibling; d) a mean interval of 50.1 +/- 32 months between acute measles and the onset ... | 1980 | 6254241 |
| interferon as a mediator of human lymphocyte suppression. | evidence is presented that interferon (if) is a major mediator of the human concanavalin a (con a) suppressor cell. the suppressive effects of con a-activated lymphocytes on the mitogen responses of normal responder cells were largely abrogated by addition of anti-human leukocyte if serum. similar suppressor activity was generated by coculture of peripheral blood leukocytes (pbl) with a melanoma cell line (mewo) and a hela cell line persistently infected with measles virus that induced the produ ... | 1980 | 6444662 |
| [antibodies to measles virus among the urban and rural population of the andizhan region]. | 1980 | 6449812 | |
| measles virus inhibits acquisition of lymphocyte functions but not established effector functions. | 1980 | 6444548 | |
| [cytological study of vero cell culture infected with measles virus, by phase contrast]. | 1980 | 6753630 | |
| [evolutive study of the intracellular dissemination of the hemagglutinin and nucleocapsid antigens of the measles virus, by indirect immunofluorescence technic]. | 1980 | 6753633 | |
| nodular residua of atypical measles pneumonia. | atypical measles pneumonia should be considered an explanation for nodular pulmonary lesions in older children and young adults. the disorder can develop in children immunized with inactivated measles virus vaccine who are then exposed to natural measles virus. individuals given the vaccine when it was used (1961--1968) are now at risk to develop atypical measles pneumonia. this pneumonia may have a lobar or diffuse bronchopneumonia pattern. three cases of this disorder are described. in one cas ... | 1980 | 6766229 |
| intranuclear polypeptides of measles and subacute sclerosing panencephalitis virus-infected cultures. | 1980 | 6766593 | |
| homotypic and heterotypic interfering activity associated with measles and subacute sclerosing panencephalitis viruses. | 1980 | 6767796 | |
| in vivo and in vitro models of demyelinating diseases. iv. isolation of hallé measles virus-specific rna from bgmk cells and preparation of complementary dna. | 1980 | 6768187 | |
| isoenzymes of succinate dehydrogenase in measles virus-infected monkey kidney cells. | succinate dehydrogenase (sdh) isoenzyme patterns were analyzed in r6ca monkey kidney cells inoculated with wild and attenuated measles virus. cell homogenates were prepared either in a sucrose--triton x-100 mixture, or in sucrose alone. in both cases the most important sdh isoenzyme pattern alterations were observed in the homogenates of cells infected with wild measles virus at 72 hours post inoculation. similar alterations occurred in homogenates of cells infected with the attenuated strain af ... | 1980 | 6769238 |
| fatal measles infection in marmosets pathogenesis and prophylaxis. | moustached marmosets (saguinus mystax) were infected intranasally with either of two low-passaged, wildlike strains of measles virus, strain edmonston or strain jm. the infection resulted in 25 and 100% mortality, respectively, 12 to 14 days after infection. clinical signs, gross pathological findings, and histology lacked the characteristic features of measles in other primates. a deficient immune response and widespread gastroenterocolitis appeared to be the main causes for the fatal outcome. ... | 1980 | 6769812 |
| radioimmunoassay of measles virus nucleocapsid antigen. | a double antibody competitive binding radioimmunoassay (ria) was developed as a tool for investigating the involvement of measles virus in persistent virus infections. the assay employs 125i-labelled measles virus nucleocapsids as the labelled antigen. nucleocapsids were purified from cytoplasmic extracts of virus-infected vero cells, treated with trypsin to prevent clumping and iodinated to a specific activity of about 15 microci/microgram. electrophoretic analysis of iodinated trypsin-treated ... | 1980 | 6770034 |
| a comparison of measles and canine distemper virus polypeptides. | the polypeptides induced by canine distemper virus (cdv) strains have been characterized by polyacrylamide slab gel electrophoresis of infected cell lysates labelled with 35s-methionine, 14c-amino acids, 3h-glucosamine and 3h-mannose, or 32p-orthophosphate. seven virus-induced polypeptides have been asigned the following nomenclature and mol. wt.: a large polypeptide l (180,000); a large glycoprotein g (77,000); a nucleocapsid-associated protein p (73,000); the nucleocapsid protein n (60,000); t ... | 1980 | 6770040 |
| antagonistic action between antibodies directed against 7-methylguanosine and polyamines on translation in vitro of rna induced by measles virus. | antibodies directed against n7-methylguanosine (m7guo) were prepared and added to a wheat germ cell-free protein-synthesizing system programmed with rna extracted from monkey cells persistently infected with measles virus. a dose-dependent inhibition of [35s]methionine incorporation was observed when rna was preincubated with anti-m7guo immunoglobulins. antibodies preincubated with m7guo did not show any inhibiting activity. the inhibitory effect of antibodies was abolished when rna was preincub ... | 1980 | 6777161 |
| suppression of morbillivirus polypeptide synthesis by viral antibody. | 1980 | 6778729 | |
| use of limited proteolysis in the analysis of measles-virus-induced polypeptides. | 1980 | 6778730 | |
| measles in patients suspected of having rocky mountain spotted fever. | diagnostic titer rises of measles antibody were observed in six of 46 paired sera from persons originally suspected of having rocky mountain spotted fever and found to be serologically negative for this disease. atypical or typical measles is now occurring relatively more frequently in adolescents and young adults and should be considered in the differential diagnosis for patients in these age groups who have undiagnosed febrile rash illnesses. | 1980 | 6771427 |
| absence of m protein in a cell-associated subacute sclerosing panencephalitis virus. | measles virus has been suggested to cause subacute sclerosing panencephalitis (sspe), a slow central nervous system disease of children. however, several questions remain about the pathogenesis of sspe. for example, it is not known whether alteration of the measles virus genome has a role in the initiation and persistence of the disease. several studies have compared the rna and protein composition of wild-type (wt) and sspe strains of measles virus in a search for markers characteristic of the ... | 1980 | 6772958 |
| susceptibility of tamarins (saguinus) to measles virus. | tamarins (saguinus mystax and saguinus labiatus) were experimentally infected with two strains of measles virus. one of the strains (jm) spread readily among the animals with a high fatality rate. the second strain (edmonston) appeared to be less pathogenic and less transmissible than strain jm. aerosol was considered the most probable mode of infection. | 1980 | 6775133 |
| ct of subacute sclerosing panencephalitis. | subacute sclerosing panencephalitis is a progressive, frequently fatal slow virus infection of the brain attacking children and young adults and caused by measles virus. computed tomography (ct) of the brain in 15 patients with this disease was normal in seven and abnormal in eight. ct demonstrated varying degrees of cortical atrophy associated with focal and multifocal low density lesions of the white matter. two cases demonstrated low density lesions of the caudate nuclei. the ct lesions were ... | 1980 | 6779587 |
| chronic, relapsing myelitis in hamsters associated with experimental measles virus infection. | chronic, relapsing myelitis has been induced in golden syrian hamsters by the intracerebral inoculation of measles virus when the animals were less than 1 day old. no acute illness was seen in animals that developed myelitis, and the onset of the myelitis was at 5 to 50 weeks after infection. in most animals the illness was slowly progressive, with hindquarter myoclonus being the most common clinical sign. occasionally the disease involved episodic limb paresis with nearly total recovery of limb ... | 1980 | 6933480 |
| antibody-independent activation of the alternative complement pathway by measles virus-infected cells. | when hela cells acutely infected with measles virus were incubated in a mixture containing only the six proteins of the alternative pathway of complement activation (c3, factors b and d, beta 1h, c3b inactivator, and native properdin) without antibody, there was activation of the alternative pathway as shown by progressive uptake of 125i-labeled c3b onto the cell surface. this c3b uptake was blocked by edta and was not shown by uninfected cells. the rate of 125i-labeled c3 uptake by infected cel ... | 1980 | 6928644 |
| virus-lymphocyte interactions: infection of tg and tm subsets by measles virus. | 1980 | 6966202 | |
| role of polyclonal activation in specific immune responses. relevance for findings of antibody activity in various diseases. | 1980 | 6970409 | |
| surface markers on lymphocytes from human cerebrospinal fluid. ii. altered patterns in subacute sclerosing panencephalitis. | 1980 | 6967405 | |
| prospects for large scale production of thermolabile products using anchorage dependent cells. | availability of culture systems for the large scale production of anchorage dependent cells is briefly outlined. studies on two thermolabile viruses (measles and influenza), showing inactivation rates of 0.1 - 0.2 log 10 per hour, clearly demonstrate the need for minimal residence time in the culture system. logistical considerations indicate that small capacity perfusion culture systems for anchorage dependent cells would give increased recovery of these products and may readily be combined wit ... | 1980 | 6988257 |
| the measles virus. | measles is one of widely spread virus infections that is a major cause of deaths in some tropical areas. the measles virus is a member of the genus of morbillivirus of the family of paramyxoviridae. the virions contain six polypeptides, including one glycoprotein; two of them are surface proteins that possess hemagglutinating and hemolytic activities, one of them is polymerase. replication of the measles virus is similar to that of other paramyxoviruses. besides the acute infection for measles v ... | 1980 | 6988693 |
| antibodies to the structural polypeptides of measles virus following acute infection and in sspe. | a solid-phase radioimmunoassay was used to determine the specificity of igg antibodies from normal sera, sera and csf from patients with sspe for the structural polypeptides of measles virus. the polypeptide specificity of antibodies from these sources were qualitatively similar; these results indicate antigenic cross-reactivity between sspe-derived (mantooth) and non-sspe-derived strains of measles virus and stimulation of antibody formation by comparable antigens. | 1980 | 6991172 |
| search for viruses in rheumatoid macrophage-rich synovial cell populations. | the adherent cells remaining after short-term culture of synovial fluid and synovial membrane cells from rheumatoid and non-rheumatoid patients were examined for the presence of a productive virus infection and for various viral antigens. labelling was carried out with 3h-thymidine and 3h-uridine followed by sucrose density gradient centrifugation of the culture supernatant. only in 1 case was there incorporation of 3h-uridine into material of density 1 . 21 g/cm3. viral antigens were tested for ... | 1980 | 6992720 |
| serological survey of measles immunization with the rimevax--rit--vaccine in a romanian district. | 1980 | 6996640 | |
| comparative aspects of pathogenicity of measles, canine distemper, and rinderpest viruses. | 1980 | 6997585 | |
| viral vaccination via the mucosal routes. | viral vaccines have been successfully administered by the mucosal route for two decades now. however, only in the last 10 years have the concepts involved in mucosal immunocompetence been well characterized. it is apparent that the bronchus-associated lymphoid tissue, the gut-associated lymphoid tissue, and the immunocompetent cells present in ocular tissue, conjunctiva, nasopharynx, genital tract, and secretions of the mammary glands represent the components of the common mucosal immune system. ... | 1980 | 6997965 |
| equilibrium centrifugation of measles virus. | 1980 | 6893151 | |
| structural polypeptides of canine distemper virus. | the structural polypeptides of two strains of canine distemper virus and the lec strain of measles virus were analysed by sds-polyacrylamide-slab-gel electrophoresis. one strain of canine distemper virus derived from a live vaccine (convac, dumex), contained six major structural polypeptides with mol.wt. of 85, 78, 59, 43, 41 and 34 x 10(3). the 85k polypeptide was glycosylated. it was interpreted to be equivalent ot the 79k glycoprotein of the measles hemagglutinin. the second strain, a rapidly ... | 1980 | 6893798 |
| isolation and immunological characterization of the nucleocapsid and membrane proteins of measles virus. | measles virus nucleoprotein (np) and matrix (m) components were purified by two different procedures. antigens were prepared by sedimenting material from 1% cutscum extracts of infected cells into the interphase between 65 and 40% sucrose and further fractionation of the interphase material in a linear cscl gradient, density range 1.20 to 1.33 g/ml. np components contaminated with some m material and cellular actin banded at 1.30 to 1.32 g/ml, but at the low density range of 1.20 to 1.22 g/ml pu ... | 1980 | 7014776 |
| [in vitro study of the interaction of rubeola virus with the peritoneal macrophages of unimmunized and immunized rats]. | in vitro peritoneal macrophage cultures of rats with no immunization against rubella virus and inoculated with these viral agents are prone to permit its intracellular proliferation and suffer a cytopathogenic effect and lysis. peritoneal macrophages of immune rats do not permit intracellular proliferation and prevent harmful viral action. in the in vivo studies, peritoneal macrophages of non-immune rats eventually show a resistance to rubella virus during the infection. our results suggest that ... | 1980 | 7017843 |
| measles giant cell pneumonia in childhood leukemia in remission. | a four-year old girl had acute lymphoblastic leukemia in remission with immunosupressive chemotherapy and complicated giant cell pneumonia. investigations by light and electron microscopy and immunoperoxidase study of autopsy material disclosed measles virus nature of the penumonia, although there was no typical rash of the disease. similar giant cells were seen in the gastric and colon mucosa, and the other of warthin-finkeldey type in the spleen, and lymph nodes of pulmonary hiluses. to the be ... | 1980 | 6930817 |
| binding sites for measles virus antigens on human b and t lymphocytes. | 1980 | 6965614 | |
| stimulation of lymphocytes from subacute sclerosing panencephalitis patients by defined measles virus antigens. | 1980 | 6966188 | |
| the response of human lymphocyte subpopulations to measles, mumps, and vaccinia viral antigens. | a proliferative assay employing virus-infected, fixed monolayers was used to examine the response of pbl and lymphocyte subpopulations to measles, mumps, and vaccinia viruses. the response obtained in this assay was shown to be virus specific. in individuals previously exposed to mumps or vaccinia viruses, a substantial proliferative response was elicited. in contrast, only a small number of individuals responded to measles virus even though they were seropositive for this virus. in the responde ... | 1980 | 6966650 |
| slow viruses and chronic disease: the contribution of epidemiology. | 1980 | 6999526 | |
| bone tissue in paget's disease of bone. ultrastructure and immunocytology. | ultrastructural observation in paget's disease of bone clarify aspects of bone cells in bone tissue and demonstrate the presence of specific intranuclear inclusions composed of microcylinders in the osteoclasts. the morphologic analysis of these structures suggests an analogy with virus material of the measles group. results obtained using indirect immunofluorescence and immunoperoxidase techniques lend further support to the hypothesis of a viral etiology in paget's disease of bone. | 1980 | 7000080 |
| [immunologic responses in the dynamics of the establishment of postvaccinal measles immunity]. | the comparative study of the humoral and cellular characteristics of antimeasles immunity in children immunized with live measles vaccine ji-16, and in children having had measles revealed that both "wild" and vaccine strains of measles virus induced similar changes in the organism of the child: the synthesis of specific antibodies belonging to different physico-chemical classes, changes in the content of different serum immunoglobulins and the suppression of the blastogenic response of peripher ... | 1980 | 6969012 |
| production of human hybridomas secreting antibodies to measles virus. | monoclonal antibodies against a variety of antigens can be produced using techniques of somatic cell hybridization between cells of rodent myeloma lines and b cells derived from animals immunized against a given antigen. however, because of the monoclonal antibodies secreted by these hybridomas are of rodent origin, their use in human immunotherapy is limited. thus the production of b-cell hybrids that secrete human monoclonal antibodies may be of considerable value. we have hybridized a hypoxan ... | 1980 | 6969366 |
| measles-specific antibodies in sera and cerebrospinal fluids of patients with multiple sclerosis. | immunoprecipitation methods were used to analyze sera and cerebrospinal fluids from patients with multiple sclerosis for measles virus-specific antibodies. the sera contained antibodies against all virus antigens except the matrix polypeptide. of the nine cerebrospinal fluids investigated, two contained undetectable levels of measles-specific antibodies, four contained antibodies against the nucleocapsid and another internal antigen, and three contained antibodies against the surface antigens as ... | 1980 | 6991427 |
| [measles cellular immunity in patients with multiple sclerosis]. | the micromethod of leukocyte migration inhibition test was used to study cellular immunity in patients with multiple sclerosis (ms) to measles virus antigens and some other infectious (vaccinia virus, tuberculin) and noninfectious (brain white matter extract) antigens. in ms patients the reaction to measles antigen was weaker than in the control group, while the reactivity to the brain white matter extract was increased. as for the responses to vaccinia virus and tuberculin, these two grous did ... | 1980 | 6992452 |
| measles retinopathy. a hamster model of acute and chronic lesions. | measles and subacute sclerosing panencephalitis strains of virus inoculated intracerebrally in suckling and weanling hamsters spread immediately to the eye via the blood. virus replicates in the brain and eye in parallel, and in higher titers than it does in other organs. acute retinal lesions consist of focal syncytia, inclusion-bearing cells, and necrosis. immunofluorescence studies show measles-specific antigen in the affected cells. ultrastructurally, measles nucleocapsids and virions are se ... | 1980 | 6993787 |