Publications

[immunohistochemical studies of the acne-like inflammatory model].	the acne-like inflammatory model was produced in the ears of male sprague-dawley rats by subcutaneous injection of 140 micrograms of heat killed propionibacterium acnes (p. acnes). ear thickness was measured as an index of inflammatory strength, using a micro indicator once every day for the first week, then every other day until the 35th day. animals were sacrificed and ears were excised for histological study. the tissue was stained with hematoxylin and eosin to investigate the state of inflam ...	1990	2147008
characterization of corynebacterium parvum-induced suppressor cells of mouse nk and adcc activity.	treatment of mice with corynebacterium parvum (cp) resulted in a substantial decrease in natural killer activity in the spleen at 10 days. the decrease in cytotoxicity was associated with the presence of splenic nonadherent (na) suppressor cells, capable of inhibiting natural as well as antibody-dependent cellular cytotoxicity (adcc). the nonadherent suppressor cells appeared to be null cells, lacking detectable expression of thy 1, l3t4 (cd4), lyt 2 (cd8), or asialo-gm1 and could be physically ...	1990	2148342
the inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne.	metronidazole is clinically effective in treating not only rosacea but also acne inflammation. yet it is generally considered not to be very effective in inhibiting the growth of anaerobic propionibacterium acnes. we report here our investigation into the synergistic effects of metronidazole and palmitoleic acid on the anaerobic growth of p. acnes as well as on human neutrophil functions, including the generation of reactive oxygen species (ros). both metronidazole and palmitoleic acid, when use ...	1990	2150301
[therapy of acne with visible light. decreased irradiation time by using a blue-light high-energy lamp].	lipophilic propionibacterium acnes stores large amounts of porphyrins. this peculiarity can be used for photodynamic destruction of propionibacteria. after repeated irradiations with a blue light-type high pressure lamp (narva nc 1000-64) both acne and seborrhoea was improved markedly (10 irradiations, each for 10 minutes, cumulative light dose 325 j/cm2). also porphyrin content inside acne follicles dropped. serial irradiations with short range visible light (400 to 420 nm) are recommended for ...	1990	2150382
colonization of adrenal glands and ovaries of mice by hsv-2 variants. i. virological studies.	hsv-2 strain er was shown to consist of variants with different pathogenic phenotype: variant er+ replicates to high titers in the adrenal glands and the ovaries but much less in the spleen; the testes were not colonized. er+ migrates to the spinal ganglia and is highly neuroinvasive after i.p. inoculation. variant er- replicates 100-1,000 fold less in the adrenal glands and the ovaries, but proceeds to the spinal ganglia without invading the cns. however, both variants are highly neuropathogeni ...	1990	2156486
effect of interferon or propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats.	seventy-four cats (52 treated and 22 untreated) were evaluated in efficacy studies of interferon (ifn), propionibacterium acnes, or a combination of these drugs against experimentally induced feline infectious peritonitis (fip). cats were given doses of recombinant human leukocyte (alpha) ifn (rhuifn-alpha), feline fibroblastic (beta) ifn (fifn-beta) or p acnes at regular intervals before and after inoculation of virulent fip virus (fipv). prophylactic and therapeutic administration of high dose ...	1990	2159739
synthesis of eicosanoids by propionibacterium acnes-elicited liver adherent cells and their effect on production of interleukin 1 and tumor necrosis factor.	when heat-killed propionibacterium acnes (p. acnes) is intravenously injected into rats or mice, liver adherent cells including macrophages and kupffer cells increase in number and they synthesize various kinds of biologically-active materials. we studied the production of eicosanoids and the cytokines, interleukin 1 (il-1) and tumor necrosis factor (tnf), by p. acnes-elicited liver adherent cells and the regulatory mechanisms of eicosanoids in the synthesis of cytokines. as a result, p. acnes-e ...	1990	2177900
[the protective effects of glucagon and insulin in an experimental massive hepatic cell necrosis model].	when heat-killed propionibacterium acnes was intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide (lps) was also intravenously injected, most of them died of massive hepatic cell necrosis. however, then glucagon (0.5 mg/kg body weight) and insulin (0.5 units/kg body weight) or glucagon (0.5 mg/kg body weight) individually were administered during this experimental induction of massive hepatic cell necrosis, the survival rate of mice increased ...	1990	2182924
the microbiology of periapical granulomas.	of the 16 periapical granulomas studied, 14 (88%) yielded a positive growth when homogenized and cultured. the concentration of colony-forming units per milliliter of the suspension ranged from 10(1.3) to 10(4.0) (mean 10(2.2)). a total of 47 isolates comprising 26 (55%) facultative anaerobes and 21 (45%) strict anaerobes were obtained. the organisms most commonly cultured were veillonella species (15%), streptococcus milleri (11%), streptococcus sanguis (11%), actinomyces naeslundii (11%), prop ...	1990	2183126
growth inhibition of candida albicans by interleukin-2-induced lymph node cells.	previous reports have demonstrated natural killer cells (nk) to exert growth inhibitory effects against certain fungi, but not against candida albicans. in this investigation, interleukin-2 (il-2)-induced lymph node cells with phenotypic and functional characteristics of nk were shown to inhibit the growth of c. albicans. growth inhibition was evaluated by both the release of 51cr by the fungus and the inhibition of microcolony growth of the fungus on sabouraud's dextrose agar. lymphoid cells de ...	1990	2188739
swab-wash method for quantitation of cutaneous microflora.	we describe a comparison of the scrub-wash method of williamson and kligman and a swab-wash method for the enumeration of cutaneous microflora. the swab-wash method provides a less traumatic alternative to the scrub-wash method and can be used to sample the cutaneous microflora of premature neonates.	1990	2191014
evaluation of the worth of corynebacterium parvum in conjunction with chemotherapy as adjuvant treatment for primary breast cancer. eight-year results from the national surgical adjuvant breast and bowel project b-10.	during the 1970s, information obtained from animal tumor models and from patients with a spectrum of solid tumors indicated the worth of a variety of immunostimulating agents. these findings provided a biological and clinical rationale for conducting randomized trials to evaluate the worth of those agents. consequently, in may 1977 the national surgical adjuvant breast and bowel project (nsabp) implemented a randomized trial to determine whether corynebacterium parvum (c. parvum, cp) plus chemot ...	1990	2196108
effect of cloxacillin prophylaxis on the bacterial flora of craniotomy wounds.	during a double-blind placebo-controlled study, the effect of cloxacillin prophylaxis in craniotomies on samples taken for culture from 334 operation wounds in 279 patients was assessed. patients and operations were equally divided over the cloxacillin and placebo groups. in the cloxacillin group significantly fewer samples contained microorganisms than was the case in the placebo group both just after the incision was made (p less than 0.05) and just before closure of the wound (p less than 0.0 ...	1990	2196671
induction of tumor necrosis factor by macrophage colony-stimulating factor in vivo.	the effect of human urinary colony-stimulating factor (csf-1) on the production of tumor necrosis factor (tnf) in vivo was assessed. purified csf-1 was administered i.v. to rabbits 4 days prior to injection with lipopolysaccharide (lps). tnf in the serum prepared from rabbits bled 90 min after lps injection was measured using cytotoxicity assays employing mouse l929 cells and antirabbit tnf monoclonal antibody. the results indicated that csf-1 was able to induce the production of tnf in vivo and ...	1990	2199615
effects of subgingival irrigation on bacteremia following scaling and root planing.	the purpose of this study was to determine the effects of professional subgingival irrigation, together with subsequent patient administered home marginal irrigation, on the incidence of bacteremia after scaling and root planing (sc/rp). a total of 60 periodontal maintenance patients were assigned to either group 1: subgingival irrigation, with 0.12% chx and daily marginal irrigation with 0.04% chx; group 2: subgingival irrigation with 0.12% chx and daily marginal irrigation with water; group 3: ...	1990	2201759
susceptibility of oral bacteria to phenoxyethanol and phenoxyethanol/chlorhexidine combinations.	a total of 57 bacterial strains (26 different species) which may be isolated from subgingival plaque were tested for their in vitro susceptibility to phenoxycthanol, a commonly-used antiseptic and preservative. ninety-five percent of the strains, including those associated with chronic inflammatory periodontal disease, were susceptible to concentrations of phenoxyethanol used topically (2% w/v). phenoxyethanol at a concentration of 1% (w/v) was also found that to have a rapid bactericidal effect ...	1990	2202809
protective effect of saikosaponin a, saikosaponin d and saikogenin d against pseudomonas aeruginosa infection in mice.	effects of saikosaponins and their genins on nonspecific resistance against pseudomonas aeruginosa and listeria monocytogenes infections were investigated. when mice were administered intraperitoneally (i.p.) saikosaponins one day before i.p. infection with p. aeruginosa, saikosaponins a and d induced a marked enhancement of nonspecific resistance at a dose of 10 micrograms/mouse. also, saikogenin d, a secondary metabolite of saikosaponin d, showed an enhancing effect. the most effective conditi ...	1990	2210914
[propionibacterium acnes septicemia in t lymphoblastic lymphoma].		1990	2221749
modulation of nitrogen oxide synthesis in vivo: ng-monomethyl-l-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage.	attempts were made to promote or inhibit nitric oxide (. n = o) synthesis in a murine model of hepatic damage (corynebacterium parvum followed by lipopolysaccharide; lps) to determine the role of . n = o in the liver injury. moderate hepatic damage and increases in circulating no2-/no3- levels were detectable after c. parvum alone. administration of lps to these mice resulted in severe hepatic damage and acute elevations in circulating nitrogen oxide levels. l-arg had no influence on the c. parv ...	1990	2230601
propionibacterium encephalitis.		1990	2230984
[the influence of coptidis rhizoma to lipase activity of propionibacterium acnes].	gas chromatography was applied for determination of the amounts of propionic and butyric acids in the medium produced by propionibacterium acnes. the organism was incubated in peptone-yeast extract-glucose medium containing 0.017 meq/ml of tributyrin and various amounts of coptidis rhizoma at 37 degrees c for 24 to 96 hr. the amount of butyric acid produced by the lipase was reduced parallel with that of propionic acid resulted from the growth of p. acnes in the medium. these facts were also con ...	1990	2232295
[new aspects of intolerance of the aqueous iodinated x-ray contrast medium, adipiodone--fatal interaction of adipiodone-ultrabil with the immunomodulators corynebacterium parvum (cp) and shigella dysenteriae endotoxin (lps)].	the authors assume a new type of interaction of the aqueous x-ray contrast substance type adipiodone (ultrabil 50% spofa) with immunomodulators of corynebacterium parvum (cp) and the endotoxin of shigella dysenteriae (lps). the fatal type of interaction developed regularly as a result of the concurrent i.v. administration of the x-ray contrast substance adipiodone with the endotoxin of shigella dys. (lps) to laboratory animals (mice) which had five days previously a single dose of corynebacteriu ...	1990	2237238
effect of cytochrome p-450 inhibition and stimulation on intensity of polyethylene degradation in microsomal fraction of mouse and rat livers.	polyethylene (pe) is degraded in microsomal fractions of mouse and rat livers with the formation of carbonyl groups. infrared spectroscopy demonstrated formation of predominantly ketone groups and to a lesser degree ester and aldehyde groups. the inhibition and stimulation of cytochrome p-450 in mouse livers affected the formation of oxidative groups on pe. phenobarbital doses of 3 x 0.05 mg per mouse increased the concentration of cytochrome p-450 and ketone groups on pe, whereas the vaccine pr ...	1990	2242403
systemic alkalinization inhibits the ability of flavone acetic acid to augment natural killer activity, induce cytokine gene expression, and synergize with interleukin 2 for the treatment of murine renal cancer.	flavone acetic acid (faa) is an investigational drug that augments natural killer activity, induces the genes for alpha- and gamma-interferon (ifn) and tumor necrosis factor alpha, and synergizes with recombinant interleukin 2 for the successful treatment of murine renal cancer. however, in most clinical studies of faa only minimal immunomodulatory effects have been reported. most of the patients in these studies have also been given sodium bicarbonate to prevent possible nephrotoxicity. the cur ...	1990	2253233
comparative in vitro activity of the new oral cephalosporin bay v 3522 against aerobic and anaerobic bacteria.	the in vitro activity of the new oral cephalosporin bay v 3522 against 229 aerobic and 330 anaerobic clinical isolates was determined using the agar dilution technique. for comparison, amoxicillin, amoxicillin/clavulanate, cefaclor, cefadroxil, cefuroxime, cephalexin, ciprofloxacin, clindamycin, co-trimoxazole, doxycycline, erythromycin and metronidazole (only anaerobic bacteria) were tested. bay v 3522 was found to have high activity against staphylococcus aureus, staphylococcus epidermidis, en ...	1990	2261923
synthesis and antibacterial activity of the metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1h,5h- benzo[i,j]quinolizine-2-carboxylic acid (opc-7251).	the metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1h,5h- benzo[i,j]quinolizine-2-carboxylic acid (opc-7251) (1), which has a potent antibacterial activity against gram-positive bacteria, characteristically propionibacterium acnes, were synthesized to confirm their structures and to examine their antibacterial activity. the structures of three major metabolites (2, 3a and 4) were identified by means of comparison with the synthetic compounds. the antibacterial activ ...	1990	2268907
bacteremia due to anaerobic bacteria in newborns.	awareness of the role of anaerobic bacteria in neonatal bacteremia has increased in recent years. the incidence of recovery of anaerobes in neonatal bacteremia varies, according to different studies, between 1.8% and 12.5%. of the 178 cases reported in the literature, 73 were due to bacteroides species (69 were the bacteroides fragilis group), 57 clostridium species (mostly clostridium perfringens), 35 peptostreptococci, 5 propionibacterium acnes, 3 veillonella species, 3 fusobacterium species, ...	1990	2277280
isolation and characterization of a polysaccharide antigen from propionibacterium acnes released by a glycine-specific chemical protein degradation procedure.	an acid-labile antigenic polysaccharide has been isolated from both cell walls and culture media of propionibacterium acnes using a new chemical degradation procedure which liberates protein-bound or associated carbohydrate. lyophilized cells and culture media were treated with a suspension of mercuric oxide in a solution of alkaline mercuric cyanide for several hours at room temperature liberating water-soluble polysaccharide material. the antigenic polysaccharide was freed of reaction products ...	1990	2282114
tnf and inhibition of growth of plasmodium falciparum.	the mechanism of intra-erythrocyte death of plasmodium chabaudi in vivo has not yet been elucidated. here we summarise recent experiments in which serum from mice undergoing a successful immune response to this parasite did not inhibit plasmodium falciparum in vivo unless the p. chabaudi infection and tnf levels were high enough to cause illness in the host. this was true for the 556ka and ds strains of p. chabaudi in intact mice, but not for 556ka in nude mice, which did not generate inhibitory ...	1990	2283147
the influence of various factors on the human resident skin flora.	various factors, e.g. prolonged occlusion, skin disinfectants, systemic antimicrobials, can have an impact on the ecosystem of the normal human skin flora for a short time. these impacts are of clinical importance in the treatment of some skin diseases, where members of the normal human skin flora are involved in the pathogenesis of the disease, e.g. propionibacterium acnes in acne vulgaris, corynebacterium species in erythrasma, trichomycosis palmellina and pitted keratolysis, pityrosporum orbi ...	1990	2285575
[torpid endophthalmitis in pseudophakia: diagnostic and therapeutic difficulties. apropos of 4 cases].	the authors report four cases of chronic endophthalmitis following extracapsular cataract extraction with intraocular lens implantation in the posterior chamber. the first attack of intraocular inflammation occurred in the form of recurrent iridocyclitis two to six months after surgery. the first attack usually responded well to local corticosteroids. after many relapses of inflammation, increasingly resistant to medical treatment, a severe attack occurred leading to the decision to treat such e ...	1990	2290004
malignant pleural effusions: meaning of pleural-fluid ph determination.	in 36 patients with malignant pleural effusions, we determined the ph and the glucose concentration of the pleural fluid. twenty-one of 36 patients (58.3%) had a low ph (less than 7.30) and 15 had a normal ph (greater than or equal to 7.30; 7.13 +/- 0.12 vs. 7.37 +/- 0.05; p less than 0.0005). the patients with low ph had significantly lower glucose concentrations than those with normal ph (2.7 +/- 1.4 vs. 6.3 +/- 2.9 mmol/l; p less than 0.0005). twenty-one of 34 patients (61.7%) had a glucose c ...	1990	2300387
lethality of morphine in mice infected with toxoplasma gondii.	opiates modulate a variety of immune responses. we investigated the effect of morphine on the pathogenesis of an acute toxoplasma gondii infection. repeated s.c. injections with morphine sulfate (300 mg/kg) every 36 hr addicted mice and increased markedly the mortality of mice infected with an avirulent strain of t. gondii (86%) vs. 0% mortality in addicted and control mice, respectively, p less than .001). however, a single challenge with morphine (300 mg/kg) also markedly (p less than .001) in ...	1990	2313590
diagnosis and treatment of chronic postoperative bacterial endophthalmitis.	bacterial endophthalmitis has been recognized as a significant cause of chronic, delayed-onset inflammation following extracapsular cataract extraction (ecce) with posterior chamber intraocular lens implantation. the diagnosis of chronic postoperative bacterial endophthalmitis should be suspected in any case of chronic, refractory inflammation following ecce. although successful treatment may require surgical intervention in some cases, others may respond to antibiotic therapy alone.	1990	2313707
dorsal midbrain encephalitis caused by propionibacterium acnes. report of two cases.	a syndrome of dorsal midbrain dysfunction in association with a central nervous system anaerobic diphtheroid infection is described. two cases of infection with propionibacterium acnes manifested as shunt malfunctions with a clinical dorsal midbrain syndrome. magnetic resonance images showed increased signal in the midbrain tectum which has decreased slowly over time. the evidence suggesting that this syndrome represents bacterial midbrain encephalitis is discussed.	1990	2319325
propionibacterium acnes orbital abscess.		1990	2322146
peripheral teflon catheters. potential source for bacterial contamination of orthopedic implants?	to detect low numbers of bacterial cells on teflon catheters removed from peripheral veins, 74 catheter tips were incubated in thioglycollate media for up to ten days. fifteen (20.3%) of the catheters were found to be culture-positive. propionibacterium acnes was isolated from seven, staphylococcus epidermidis from six, and staphylococcus haemolyticus and staphylococcus hominis from one each, all common skin organisms associated with infection of implants. an increase in documentation of bacteri ...	1990	2323139
propionibacterium acnes endophthalmitis two years after extracapsular cataract extraction.		1990	2333931
[monitoring natural killer cell activity in the blood of patients with malignant pleural effusion after intrapleural administration of corynebacterium parvum].	in a group of 14 patients with a malignant pleural effusion treated by intrapleural administration of corynebacterium parvum, in addition to other treatment of the generalized malignant process the activity of nk cells was investigated before administration, on the 7th and 21st day after instillation of the vaccine. the mean rise of this activity was significant at the 5% level of significance. the activity of nk cells was equally significantly influenced by age. the survival of patients, althou ...	1990	2340567
propionibacterium acnes in a spondylitis with palmoplantar pustulosis.		1990	2344218
enhanced tumor necrosis factor and interleukin-1 in an experimental model of massive liver cell necrosis/fatal hepatitis in mice.	studies were conducted to investigate possible roles of tumor necrosis factor (tnf) and interleukin-1 (il-1) in liver cell necrosis/fatal hepatitis in mice which were injected with propionibacterium acnes (p.acnes) and subsequently 7 days later with a small dose of lipopolysaccharide-endotoxin (lps). higher serum levels of tnf were observed in the model, and enhanced production of both tnf and il-1 was also found in hepatic as well as splenic adherent cells that were isolated from mice pretreate ...	1990	2358165
the interaction of naegleria fowleri amoebae with murine macrophage cell lines.	the present study was undertaken to determine whether murine macrophage cell lines exhibited in vitro amoebicidal activity comparable to that elicited by activated murine peritoneal macrophages. peritoneal macrophages activated in vivo by bacillus calmette-guérin or propionibacterium acnes demonstrated significant cytolysis of naegleria fowleri amoebae. the macrophage cell line raw264.7 also effected cytolysis of amoebae, but to a lesser extent than that elicited by activated peritoneal macropha ...	1990	2359044
[comparative study of the bacterial flora in both uterocervical and uterine regions].	the relationship between indigenous bacterial floras in the lower genitals and the uterocervical region is of importance due to a barrier-like role against ascending infections through the mechanism of the localized protection at a boundary of the uterocervical region. therefore, bacterial flora in the uterocervical and uterine regions was studied in cases for which gynecological operations were performed (n = 77). 1. ratios of incidences of the detection of bacteria on the uterocervical and in ...	1990	2362354
effector phenotype and immunologic specificity of t-cell-mediated adoptive therapy for a murine tumor that lacks intrinsic immunogenicity.	the mca 102 sarcoma has been defined by a variety of immunologic studies as a tumor lacking intrinsic immunogenicity. nevertheless, we have recently demonstrated the feasibility of generating therapeutically effective lymphocytes for adoptive immunotherapy of this tumor. procedures to achieve this required in vivo priming of syngeneic mice to elicit preeffector cells followed by in vitro sensitization (ivs) with tumor cells in the presence of il-2. by selective depletion of t cell subsets in viv ...	1990	2364440
vaccination of humans against cutaneous leishmaniasis: cellular and humoral immune responses.	brazilian army conscripts were vaccinated against american cutaneous leishmaniasis by using nonliving polyvalent promastigote leish vaccine 5 or leish vaccine 6 (vaccines with five or six leishmania stocks) with or without corynebacterium parvum. no statistically significant differences in lymphocyte stimulation indices were found between vaccinated groups with or without c. parvum, but lymphocyte stimulation indices of all vaccinees were significantly higher (p less than 0.001) than those of th ...	1990	2365458
bacteria from solid tumours.	bacteria were grown from 63 (69%) of 91 specimens from necrotic tumours in 63 patients. of the tumours, 14 were abdominal, 5 pelvic, 23 of the head and neck, 4 of the lungs, 4 mediastinal, 2 lymphatic, 3 of the breast, and 8 were miscellaneous. aerobic or facultatively anaerobic bacteria only were present in 12 (19%) specimens, anaerobes only in 10 (16%), and mixed aerobic and anaerobic bacteria in 41 (65%). a total of 83 anaerobic and 47 aerobic and facultatively anaerobic bacteria were isolate ...	1990	2374159
[histochemical study of proliferating cells in the spleen in mice with acute hepatic injury].	when heat-killed propionibacterium acnes (p. acnes) and lipopolysaccharide (lps) were injected into mice, liver cell necrosis with infiltrating neutrophils and macrophages were induced. proliferating cells in the spleen were histochemically investigated. p. acnes injection rapidly produced hyperplasia of neutrophils and macrophages in the red pulp of the spleen. the proportion of bromodeoxyuridine positive cells reached a peak at 5 days after injection of p. acnes. these results indicate that pr ...	1990	2376907
involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.	the possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. balb/c mice were primed with propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. immunohistochemical study showed that most of the accumulated mononuclear cells at 7 days were mac-2 positive, suggesting that they were activated macrophages. an injection of lipopolysaccharide resulted in massive hepatic necrosis and high mortality ...	1990	2379780
infectious arthritis caused by propionibacterium acnes: a new case.		1990	2396878
contact neodynium-yttrium-aluminum garnet laser acts as a sterilizing scalpel.	as a cold knife cuts through contaminated or infected wounds, bacteria are dragged along with the blade of the knife through the entire wound. herein, the effect of incisions made with a cold knife is compared with that of incisions made by a contact neodynium-yttrium-aluminum garnet (nd:yag) laser. agar plates were inoculated with multiple strains of exogenous, endogenous, hospital-acquired and multiple antibiotic resistant strains of bacteria. while the cold knife dragged bacteria to sterile a ...	1990	2403698
complications associated with ommaya reservoirs in patients with cancer. the princess margaret hospital experience and a review of the literature.	the complications associated with the use of ommaya reservoirs in 106 patients with meningeal involvement due to malignant disease are reviewed. twenty-seven patients had acute lymphoblastic leukemia, 12 acute myelogenous leukemia, 3 chronic lymphocytic leukemia, 34 lymphoma, 29 carcinoma, and 1 chronic myelocytic leukemia. there were 11 technical complications, including 1 death due to misplacement of the catheter, 2 mild intraventricular hemorrhages, and 5 malfunctioning reservoirs; 3 required ...	1990	2404479
chronic postoperative endophthalmitis associated with actinomyces species.	actinomyces species, gram-positive, non-spore-forming anaerobic bacilli were isolated from intraocular fluid obtained from four otherwise healthy patients with a delayed onset of postoperative endophthalmitis. one patient had a mixed anaerobic infection with recovery of both actinomyces israelii and propionibacterium acnes. in all four patients, early postoperative visual acuity was good but was eventually markedly reduced by intraocular inflammation that was first observed between 21 days and 4 ...	1991	1987950
persistent biological reactivity of quartz in the lung: raised protease burden compared with a non-pathogenic mineral dust and microbial particles.	this study assessed the potential harmfulness of particles in the lung by measuring their ability to elicit and maintain an inflammatory response and to damage lung tissue. it compared the inflammogenicity of two nondurable, biological particulates (corynebacterium parvum and zymosan) with a pathogenic mineral dust (quartz) and a nonpathogenic dust (titanium dioxide) by dosing rats via the intratracheal route and measuring the consequent alveolitis. the magnitude and duration of the inflammatory ...	1991	1993161
involvement of tumor necrosis factor alpha in experimentally induced hepatitis.		1991	2001820
neutrophil and kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver.	the hypothesis that kupffer cells and infiltrating neutrophils generate reactive oxygen in the hepatic sinusoids and may contribute to ischemia-reperfusion injury in the liver was investigated in a model of partial no-flow ischemia and reperfusion in male fischer rats in vivo. during the reperfusion period of 60 min, plasma concentrations of glutathione disulfide (gssg; index of oxidant stress) increased from 1.62 +/- 0.20 microm glutathione (gsh) equivalents to maximal values of 11.82 +/- 1.45 ...	1991	2003603
endotoxin-induced cytokine gene expression in vivo. iii. il-6 mrna and serum protein expression and the in vivo hematologic effects of il-6.	endotoxin (lps) at sublethal doses injected i.v. into rats was found to induce il-6 mrna expression peaking at 1 to 2 h in whole organ rna preparations of the spleen, liver, lung, bowel, and kidney. il-6 serum protein levels also peaked at 2 h. tnf and il-1, generally considered to be among the most rapidly released cytokines, also induced il-6 expression. il-6 in turn inhibited tnf and il-1 expression, suggesting that il-6 may be part of a negative feedback mechanism in the cytokine cascade. de ...	1991	2005401
delayed-onset pseudophakic endophthalmitis.		1991	2021185
pathogenicity of propionibacterium acnes in mixed infections with facultative bacteria.	single and mixed infections with 11 clinical isolates of propionibacterium acnes and three facultative bacteria (staphylococcus aureus, escherichia coli and klebsiella pneumoniae) were studied in a subcutaneous abscess model in mice. abscesses were induced by pure cultures of six of 11 strains of p. acnes and by the three facultative bacteria. the abscesses produced by each of the six "virulent" p. acnes isolates mixed with s. aureus, e. coli or k. pneumoniae were larger than those induced by th ...	1991	2030499
role of tumour necrosis factor in the tumour-necrotizing activity of agents with diverging toxicity.	we investigated the ability of various tumour-necrotizing agents with diverging toxicity to induce tumour necrosis factor (tnf) and cytostatic activity in propionibacterium-acnes-primed swiss and tumour-bearing balb/c mice, and the capacity of anti-tnf antibodies to inhibit induction of tumour necrosis by the agents. lipid a and especially its combination with muramyl dipeptide induced high tnf levels in swiss mice, as measured in the serum. lower levels were induced by detoxified lipid a and th ...	1991	2036659
tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in d-galactosamine-treated mice.	treatment with d-galactosamine increases sensitivity of lipopolysaccharide (lps)-responder mice to the lethal effects of lps, while nonresponder mice remain resistant (m.a. freudenberg, d. keppler, and c. galanos, infect. immun. 51:891-895, 1986). in the present study it is shown that, in contrast to lps, killed gram-negative bacteria (salmonella abortus equi and s. typhimurium) were highly toxic for d-galactosamine-treated lps-responder (c57bl/10 scsn and c3h/hen) and -nonresponder (c57bl/10 sc ...	1991	2037372
influence of biological response modifiers of bacterial origin on disease progression in the mrl-lpr model of systemic lupus erythematosus.	murine models of systemic lupus erythematosus exhibit some, but not all of the characteristics of human disease. disease progression in the animal models is related to autoantibodies, genetics, and inflammatory processes. in this report the effects of two bacterial biological response modifiers (brm) on disease progression in the mrl-lpr model were investigated. the two brm tested were c. parvum and bacillus-calmette-guerin (bcg), both of which are stimulators of the reticuloendothelial system a ...	1991	2040105
effects of irsoglandine maleate in an experimentally-induced acute hepatic failure model using mice.	when heat-killed propionibacterium acnes was intravenously injected into mice followed by an intravenous injection of a small amount of gram-negative lipopolysaccharide seven days later, most of the mice died of massive hepatic cell necrosis within 24 hours. however, when irsoglandine maleate, an anti-ulcer agent, was administered to mice during the period of experimental induction of acute hepatic failure, the survival rate, serum transaminase levels and histological changes of the liver remark ...	1991	2040400
corynebacterium parvum versus bacille calmette-guérin adjuvant immunotherapy of stage ii malignant melanoma.	two separate studies have been reported comparing corynebacterium parvum and bacille calmette-guérin (bcg) as adjuvant immunotherapy for stage ii melanoma patients (the milton s. hershey medical center, 48 patients; southeastern cancer study group [secsg], 162 patients). as the criteria for patient selection and drugs used were similar, we have pooled the data to analyze the effects of these two treatments. both studies used bcg (tice, chicago, il) 3 x 10(8) live organisms per treatment by tine ...	1991	2045856
t-cell reactivity to purified lipophosphoglycan from leishmania major: a model for analysis of the cellular immune response to microbial carbohydrates.	the major macromolecule on the surface of leishmania major promastigotes is a lipophosphoglycan (lpg). this glycoconjugate plays a key role in determining infectivity and survival of parasites in the mammalian host cell. in addition, l. major lpg is able to induce a host-protective immune response. in this article, we summarise the evidence for recognition of highly purified lpg by t cells and we discuss the potential mechanisms of t-cell stimulation by this non-protein antigen.	1991	2049034
ruffle formation in the evaluation of stimulatory state of hepatic macrophages in rats.	morphological changes in hepatic macrophages after stimulation were observed with a transmission electron microscope in rats. in the normal liver ruffle formation occupied less than 30% of the cell surface facing the sinusoidal space in 21 of 25 macrophages. when the rats received a dose of carbon tetrachloride, hepatic macrophages 1 day later showed ruffle formation to the same extent as in normal rats. in contrast, in rats 6 days after a dose of corynebacterium parvum, ruffle formation was int ...	1991	2051902
mr imaging in an experimental model of brain tumor immunotherapy.	a murine model of implanted cns neoplasia was used to study a new form of brain tumor immunotherapy with intralesional corynebacterium parvum (c. parvum). assessment of treatment protocols has been limited by the inability to assess, noninvasively, tumor burden and/or the inflammatory reaction induced in the murine brain by treatment with c. parvum. this study demonstrates that contrast-enhanced mr imaging can monitor in vivo tumor burden and the immune response to intracerebral c. parvum. kht m ...	1991	2058511
immunohistochemistry of the inflammatory response in propionibacterium acnes endophthalmitis.	specimens were obtained from two patients with culture-proven propionibacterium acnes endophthalmitis who had undergone vitrectomy. wright's and giemsa stains were performed using cytospin preparations of the dilute vitreous and revealed a predominance of polymorphonuclear leukocytes (80% to 90%). the remaining inflammatory cells in the vitreous were mostly macrophages (10% to 15%); very few lymphocytes were present (less than 5%). immunohistochemical studies using monoclonal antibodies confirme ...	1991	2064579
bacterial contamination in irreversible hydrocolloid impression material and gingival retraction cord.	this study tested two dental materials in factory-sealed containers for the presence of bacteria that may be a source of infection. twenty samples of two dental materials found to have contamination in a pilot study were taken from unopened containers using a sterile technique. the samples were inoculated onto chocolate agar plates and into thioglycolate broths with appropriate controls. plates were examined, colonies were enumerated, gram stained, and identified. the resulting contamination fre ...	1991	2066885
cutaneous immunopathology of androgenetic alopecia.	male pattern baldness is assumed to result from a combination of normal serum concentrations of androgen and an appropriate genetic background. to study whether inflammation contributes to the development of androgenetic alopecia, direct immunofluorescence and dermatopathologic studies were performed on biopsy specimens from bald scalp of patients, with specimens from uninvolved scalp of these patients or from scalp of volunteers who were not bald serving as controls. granular deposits of immuno ...	1991	1744007
inhibition of immune reactions in vivo by liposome associated transforming growth factor (tgf) type beta 1.	in view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (tgf) beta 1 to down-regulate immune responses in vivo. preliminary experiments suggested that, at the doses used, systemic injection of soluble tgf beta 1 could not affect bacterial-induced spleen enlargement in mice. therefore, we sought to utilize a physiochemical property of this molecule, namely its high pi, to determine possible association between the liga ...	1991	1747960
[intrascrotal and seminal vesicular granuloma probably induced by propionibacterium acnes].	a case of right intrascrotal and seminal vesicular granuloma probably induced by propionibacterium acnes is reported. a 62-year-old man was admitted to our department because of low grade fever and the right intrascrotal and retrovesical masses without tenderness. ultrasonography computed tomography, magnetic resonance imaging and vesiculography suggested a neoplasm. however, leukocytosis and high erythrocyte sedimentation rate (esr) and c-reactive protein level (crp) suggested inflammatory dise ...	1991	1755428
efficacy of cloxacillin prophylaxis in craniotomy: a one year follow-up study.	a previous prospective double-blind placebo-controlled study showed that cloxacillin prophylaxis significantly reduces the rate of infection after craniotomy. the purpose of the present follow-up study was to find out whether the data on routine cloxacillin prophylaxis would confirm the decreased infection rate after craniotomy. during this 1-year study, 8 infections occurred after 201 operations (4.0%) in 175 patients. no prophylaxis was given during 17 operations in 15 patients; 4 infections o ...	1991	1767259
propionibacterium acnes endophthalmitis.		1991	1768654
posterior lens capsule abscess due to propionibacterium acnes and staphylococcus epidermidis following extracapsular cataract extraction.	a case of posterior lens capsular abscess occurring many months after an extracapsular cataract extraction is presented. this was caused by a mixed infection involving propionibacterium acnes and staphylococcus epidermidis. the significance of staph epidermidis after such a long postoperative period is uncertain, but the case shows features typical of secondary endophthalmitis due to p acnes, including a long delay in onset and a grumbling course not brought under control by medical treatment. i ...	1991	1768656
effect of gomisin a in the prevention of acute hepatic failure induction.	nearly all rats develop massive hepatic cell necrosis and die upon intravenous administration of heat-killed propionibacterium acnes followed by a small amount of gram-negative lipopolysaccharide 7 days later. however, when such an experimental liver disorder is induced in rats raised for 4 or more weeks on food containing 0.06% of gomisin a extracted and purified from schizandra chinensis, the survival rate rises, histological changes of the liver improve remarkably, and splenocyte reactivity t ...	1991	1775571
[activation of the resident microbial flora as a possibility for the improvement of humoral antibody potentials].	the effect of a parenteral application of an adjuvant (propionibacterium acnes) and an adjuvant/antigen combination (staphylococcus aureus cowan i/al(oh)3, pseudomonas aeruginosa/al(oh)3 respectively, was tested with regard to the improvement of antibacterial resistance. parameter was the humoral antibody production (igg) of rabbits against six facultative pathogen bacterial species (st. aureus, sc. faecium, bac. cereus, p. multocida, e. coli, ps. aeruginosa) and against sheep rod blood cell mem ...	1991	1786043
latex agglutination test: an adjunct to the laboratory diagnosis of pyogenic bacterial meningitis.	gram stain, culture and latex agglutination test (lat) of cerebrospinal fluid were performed in 50 patients clinically diagnosed as suffering from pyogenic bacterial meningitis. using all the three techniques, an aetiological diagnosis was made in 27 (54%). neisseria meningitidis, streptococcus pneumoniae and h. influenzae were the infecting organisms in 21 cases (44%). there were 12 additional cases in which lat was the only clue to the diagnosis as compared to conventional techniques. propioni ...	1991	1800334
comparative in vitro activity of cefpodoxime against anaerobes other than bacteroides fragilis.	to assess the in vitro activity of cefpodoxime against anaerobic respiratory tract and oropharyngeal pathogens 77 strains belonging to 18 gram-negative and 7 gram-positive species were studied by means of agar dilution tests. for comparison cefuroxime, amoxicillin, amoxicillin + clavulanic acid and clindamycin were also tested. cefpodoxime was found to be active at concentrations of less than or equal to 0.125 mg/l against prevotella oralis, prevotella buccalis, prevotella bivia, porphyromonas a ...	1991	1800380
[counts of selected strict and facultatively anaerobic microorganisms in the crop and appendix of chickens and their adhesion characteristics].	the counts of strictly anaerobic amylolytic and lactate-utilizing bacteria, streptococci, lactobacilli, escherichia coli and lactoso-negative bacteria were followed in chicks at the age of three to seven weeks. age dependences of the counts in the given groups were investigated. an increase in the counts of amylolytic bacteria was observed in the caecum contents in the seventh week (4.63 +/- 0.322), and on the other hand a decrease in their counts in the caecum wall in the seventh week (3.30 +/- ...	1991	1807031
hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1h-1-benzazepin-3,5-dione hydrochloride (kf-14363) in various experimental liver injuries.	hepatoprotective effects of kf-14363 were investigated in the following experimental models. kf-14363 inhibited the increase in serum glutamate pyruvate transaminase (gpt) dose-dependently, and a significant inhibition was noted at a dose of 30 mg/kg or more. kf-14363 significantly inhibited the d-galactosamine (d-gal)-induced increase in serum transaminase by oral administration at 250 mg/kg x 1 and 250 mg/kg x 2 doses. the d-gal-induced decrease in total protein levels was inhibited at doses o ...	1991	1812294
correlation between antimicrobial activity and chelating ability of 2-(n,n,n-trialkylammonio)alkyl hydrogen phosphates.	the chelating abilities of phosphobetaines [2-(n,n,n-trialkylammonio)alkyl hydrogen phosphates; 1] for divalent cations (e.g., calcium ion, zinc ion, copper ion, and cadmium ion) were investigated to elucidate the correlation between the antimicrobial activity and the chelating ability. the maximal chelating ability was obtained with the compound having a dimethylene bridge as an intercharge distance between the phosphate and quaternary ammonium group; in contrast, the minimum was obtained with ...	1991	1815056
acne vulgaris. pathogenesis and treatment.	acne vulgaris is a multifactorial disease involving abnormalities in follicular keratinization, sebum production, proliferation of propionibacterium acnes, and inflammation. treatment is directed toward reversing these underlying pathogenic factors. therapeutic options include topical comedolytics, topical and systemic antibiotics, hormonal manipulations, and oral retinoids.	1991	1831256
immunomodulation in an apparently non-immunogenic murine tumor.	madison lung carcinoma (m109), a murine tumor of spontaneous origin, appears to be non-immunogenic, according to 2 commonly employed tests for tumor immunogenicity. however, c.parvum-induced immunopotentiation during the growth of m109 tumor results in post-excision anti-tumor immunity to m109 tumor implants. the c.parvum-potentiated post-excision immunity to m109 is tumor-specific and t-cell-dependent. t cells from mice whose progressive m109 tumors have been excised are capable, on passive tra ...	1991	1833344
effects of subminimal inhibitory concentrations of erythromycin, tetracycline, clindamycin, and minocycline on the neutrophil chemotactic factor production in propionibacterium acnes biotypes 1-5.	biotypes 1-5 propionibacterium acnes (p. acnes) strains were grown in the presence of 1/10 minimal inhibitory concentrations (sub-mic) of erythromycin (em), tetracycline (tc), clindamycin (cldm), or minocycline (mino) and their culture filtrates were assayed for human neutrophil chemotactic activity using boyden chamber methods. the addition of sub-mic of mino to the medium strongly suppressed the neutrophil chemotactic activity of the culture filtrates of p. acnes strains of all biotypes. in co ...	1991	1834712
acne: current concepts of pathogenesis and approach to rational treatment.	acne is a skin disorder of the sebaceous follicles that commonly occurs in adolescence and young adulthood. the pathogenesis involves abnormal follicular hyperkeratosis and obstruction of the follicle, stimulation of sebaceous gland secretion by androgens, and proliferation of propionibacterium acnes, which promotes inflammation. treatment regimens should be designed based upon an understanding of the multifactorial basis of pathogenesis. both topical and systemic agents may be employed to norma ...	1991	1835004
the effects of adjuvants on immune responses in cattle injected with a brucella abortus soluble antigen.	five different adjuvants were examined for potentiation of humoral and cell-mediated immune (cmi) responses in cattle to a brucella abortus soluble antigen (basa). two separate experiments were performed involving a total of 64 steers, divided among six groups (experiment 1) and 9 groups (experiment 2). the adjuvants used were: muramyl dipeptide, freund's incomplete adjuvant, dimethyl-dioctadecyl ammonium bromide (dda), bordetella pertussis and propionibacterium acnes. in each experiment, three ...	1991	1835213
seborrheic skin and acne vulgaris as protective factors against the development of basal cell epithelioma.	this study was conducted in order to evaluate a possible protective role of seborrheic complexion and a history of acne on the development of basal cell epithelioma (bce). for this purpose, 77 patients with this tumor were examined and asked to fill out a questionnaire. the questionnaire included demographic data and questions about skin type, eye and hair colors, sun exposure habits and a past history of acne. the nature, number and location of tumors, the texture of skin and acne scars were no ...	1991	1835940
effects of subminimal inhibitory concentrations of minocycline on neutrophil chemotactic factor production in comedonal bacteria, neutrophil phagocytosis and oxygen metabolism.	comedonal bacteria, propionibacterium acnes, p. granulosum and coagulase-negative staphylococci (cns) seem to play an important initiating role in the inflammatory process by producing neutrophil chemotactic factors. the attracted neutrophils, after phagocytosis, release inflammatory factors such as reactive oxygen species (ros). we investigated the effects of minocycline at subminimal inhibitory concentrations (sub-mic), i.e. one-tenth mic, on the production of human neutrophil chemotactic fact ...	1991	1838472
pathogenesis and pathogenesis related treatment of acne.		1991	1838558
clinical and bacteriologic evaluation of opc-7251 in patients with acne: a double-blind group comparison study versus cream base.	twenty-eight patients with acne were assigned to 4 weeks of treatment with opc-7251 (a new fluoroquinolone derivative) 1% cream or the cream base in a double-blind manner to evaluate the antibacterial effect of the drug on resident bacteria in the hair follicles and to evaluate clinical response. propionibacterium acnes was isolated from 21 of the 28 acne patients. when the number of p. acnes was compared before and after treatment, the posttreatment p. acnes count in the opc-7251 1% cream group ...	1991	1838749
an open study of teicoplanin in the treatment of gram-positive infections.	teicoplanin, a new glycopeptide antibiotic similar to vancomycin, was evaluated in treating 36 hospitalized patients suffering from various gram-positive infections. the 36 patients received teicoplanin once daily as a mean intravenous injection of 550 mg/day (range 200-800 mg/day). previous antimicrobial therapy was used in 28% of patients. the mean duration of therapy was 7.5 days (range 3-38 days). the overall clinical success rate was 94%. 24/36 patients (66%) had positive microbiology. elim ...	1991	1839742
[immunomodulating properties of acnevac vaccine].	the influence of acnevac vaccine on immune responses of cba mice was tested. acnevac, the vaccine used in a treatment of patient with acne vulgaris, was produced by a cracow sera and vaccines manufacturer from cultures of propionibacteria-strains. it was shown that acnevac has strong immunomodulatory properties. it strongly stimulates humoral responses, has moderate effect on cell-mediated immune responses and it also activates peritoneal macrophages to release tnf-alpha.	1991	1840429
torulopsis candida (candida famata) endophthalmitis simulating propionibacterium acnes syndrome.	four months after undergoing extracapsular cataract extraction with implantation of a posterior chamber intraocular lens, a 74-year-old woman developed granulomatous anterior uveitis. although she initially responded well to corticosteroid therapy, she experienced multiple recurrences on discontinuation of this therapy. slit-lamp examination showed the ocular inflammation to be associated with white cortical material within the lens capsular sac. she underwent removal of the implant as well as t ...	1991	1841584
controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy.	skin absorption of benzoyl peroxide from a topical lotion containing freely dispersed drug was compared with that from the same lotion in which the drug was entrapped in a controlled-release styrene-divinylbenzene polymer system. in an in vitro diffusion system, statistically significant (p = 0.01) differences were found in the content of benzoyl peroxide in excised human skin and in percutaneous absorption. in vivo, significantly (p = 0.002) less benzoyl peroxide was absorbed through rhesus mon ...	1991	1869643
nosocomial infections of ocular conjunctiva in newborns delivered by cesarian section.	colonization of the ocular conjunctiva in newborns delivered by cesarian section occurs usually within the first day of life. we have studied the flora of the ocular conjunctiva at birth, from 19 newborns delivered by cesarian section, coming from two different maternity hospitals. ocular conjunctiva cultures yielded the main predominant flora in both maternity hospitals considered. the most common genus of this flora are: staphylococcus, corynebacterium and propionibacterium acnes. peptostrepto ...	1991	1870845
[refractory hiccup after intrapleural injection of corynebacterium parvum].		1991	1882165
fate of the fellow eye after propionibacterium acnes endophthalmitis.		1991	1882935
protective effect of (4r)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (sa3443), a novel cyclic disulfide, on immunologically induced liver injuries in mice.	the effects of (4r)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4- carboxylic acid (sa3443), a novel cyclic disulfide, on new immunological liver injury models were investigated. the first liver injury model included a single injection of rabbit anti-basic liver protein antibody into dba/2 mice. serum transaminase activities showed a dose-dependent increase 42 hr after the antibody treatment. sa3443 significantly inhibited the elevation of serum transaminase activity and the histopathologica ...	1991	1888226
the importance of positive bacterial cultures of specimens obtained during clean orthopaedic operations.	microbiological cultures of specimens of tissue and of fluids from the wound in forty patients who had had consecutive clean, elective orthopaedic operations (excluding total joint replacements) and had not received antibiotics preoperatively were analyzed. of the forty patients, twenty-three (58 per cent) had a positive culture on at least one of the media that were used and seventeen (43 per cent) had negative cultures. of the forty specimens that were obtained from swabbing of the wound, eigh ...	1991	1890121
effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo.	nitric oxide, a highly reactive radical, was recently identified as an intermediate of l-arginine metabolism in mammalian cells. we have shown that nitric oxide synthesis is induced in vitro in cultured hepatocytes by supernatants from activated kupffer cells or in vivo by injecting rats with nonviable corynebacterium parvum. in both cases, nitric oxide biosynthesis in hepatocytes was associated with suppression of total protein synthesis. this study attempts to determine the effect of nitric ox ...	1991	1899557