Publications

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biochemical studies of skeletal muscle mitochondria. i. microanalysis of cytochrome content, oxidative and phosphorylative activities of mammalian skeletal muscle mitochondria. 19684970348
cell wall or membrane mutants of bacillus subtilis and bacillus licheniformis with grossly deformed morphology. 19684970364
seapration of b. subtilis dna into complementary strands. ii. template functions and composition as determined by transcription with rna polymerase. 19684970113
separation of b. subtilis dna into complementary strands. 3. direct analysis. 19684970114
alterations of dna base composition in bacteria. 19684970116
[the role of iron in the production and the purification of levane-sucrase. effects on the purified enzyme]. 19684970139
[regulator mechanisms in purine nucleotide synthesis]. 19684973757
bacterial inhibition by amniotic fluid. 19684972852
changes in enzyme activity and conformation during regeneration of native bacterial amylase from its denatured form. 19684972873
properties of thiol-subtilisin. the consequences of converting the active serine residue to cysteine in a serine protease. 19684973231
mechanism of the paradoxical stimulation of ribonuclease synthesis in bacillus subtilis by actinomycin d. 19684973247
genetic similarity between the ribosomal rna from spores and vegatative cells of bacillus subtilis. 19684973248
the formation of n-formyl-methionyl-puromycin by intact cells of four different bacteria and a blue-green alga. 19684973249
inactivation and mutagenesis on isolated dna. iv. possibility of integration of lethal damage into the chromosome of bacillus subtillis during transformation. 19684973255
fine structure of the mesosome and nucleoid in frozen-etched bacillus subtilis. 19684974078
[metabolic products of microorganisms. 62. the inhibition of the incorporation of threonine in srna in cell-free systems and of the synthesis of proteins and nucleic acids in the cell by the antibiotic borrelidin]. 19684974079
apparent dependence of transformation on the stage of deoxyribonucleic acid replication of recipient cells. 19684974083
alteration of host specificity in bacillus subtilis. 19684974084
identification of conserved genetic functions in bacillus by use of temperature-sensitive mutants. 19684974085
factors affecting bacterial competence for transfection and transfection enhancement. 19684974086
infectivity of bacillus subtilis bacteriophage deoxyribonucleic acids extracted from mature particles and from lysogenic hosts. 19684974087
host macromolecular synthesis in bacteriophage-infected bacillus subtilis. 19684974089
[stabilization of potential transformants of bacillus subtilis]. 19684974108
[on the evolution of endopeptidases. vi. specific inhibition by hirudin of proteases from vertebrates and invertebrates]. 19684974182
loss of viability and respiration of bacillus subtillis grown in peptone medium supplemented with glucose. 19684974257
concerted inhibition of isocitrate dehydrogenase by glyoxylate plus oxalacetate. 19684974271
regeneration of the native three-dimensional structure of bacillus subtilis alpha-amylase and its formation in biological systems. 19684974272
properties of glucose dehydrogenase from vegetative cells of bacillus subtilis and effect of dipicolinic acid and its chemical analogues on the enzyme. 19684974279
[sensitivity of the development of competence to disturbances of the steady state in the genetic transformation of bacillus subtilis]. 19684973457
separation of b. subtilis dna into complementary strands, i. biological properties. 19684973487
studies of dna replication in vivo, ii. evidence for the second intermediate. 19684973488
some properties of deoxyribonucleic acid in competent bacillus subtilis. 19684973550
productive infection of bacillus subtilis 168, with bacteriophage sp-10, dependent upon inducing treatments.strains of bacillus that harbor defective phage pbsx were found to be insensitive to sp-10(c), although the phage adsorbed to these insensitive strains. strains that did not carry the phage were sensitive to sp-10(c). b. subtilis 168 ind(-), which can be tranduced by sp-10(c) but is nonpermissive for the phage, was rendered phage-sensitive after treatment with ultraviolet (uv) light or mitomycin c. after induction with uv light, maximal sensitivity to sp-10(c) was obtained at a multiplicity of i ...19684973570
comparison of the action of vantocil, cetrimide and chlorhexidine on escherichia coli and its spheroplasts and the protoplasts of gram positive bacteria. 19684973618
inhibition of aconitase by chelation of transition metals causing inhibition of sporulation in bacillus subtilis. 19684973619
studies on the synthesis of deoxyribonucleic acid. i. further purification and properties of the deoxyribonucleic acid polymerase induced by infection of escherichia coli with bacteriophage t5. 19684973620
studies on the synthesis of deoxyribonucleic acid. ii. studies with biologically active templates and the stimulation of synthesis by oligonucleotides. 19684973621
the essentiality of histidine in the catalytic action of subtilisin. covalent modification by a specific reagent. 19684972777
mechanisms of enhancement of sp82 transfection.sp82 transfection in bacillus subtilis could be markedly increased by exposing the competent cells to ultraviolet (uv)-irradiated homologous or heterologous cellular deoxyribonucleic acid (dna). this enhancement was similar in time and level of peak effect to enhancements effected by preinfection with helper phages or by uv irradiation of competent cells. the effectiveness of various dna preparations in increasing transfection paralleled the adenine plus thymidine content of the preparations and ...19684972781
transducing particles of pbs 1. 19684972797
physical and biological properties of phage phi 29 deoxyribonucleic acid.deoxyribonucleic acid (dna) molecules having a mean length of 5.8 mum were released from purified bacillus subtilis bacteriophage phi29 with 2 m sodium perchlorate. small 0.1 to 0.2-mum molecules were also detected in these dna preparations. since intact single chains annealed to form linear duplex molecules, phage phi29 dna was found to be nonpermuted. the molecular weights of single chains of phi29 dna were approximately half that of native dna, as determined by analytical band sedimentation i ...19684972802
production of two proteolytic enzymes by a transformable strain of bacillus subtilis. 19684972346
altered ribosomes in spiramycin-resistant mutants of bacillus subtilis. 19684972350
inactivation of transforming dna by tritium distintegrations in vivo. 19684972351
the inhibition of bacterial rna synthesis by the rifamycin antibiotics. 19684972352
transfer rna as a cofactor coupling amino acid synthesis with that of protein. 19684972364
mutability of stored spores of bacillus subtilis. 19684972407
ribonucleic acid and protein synthesis in a mutant of bacillus subtilis defective in potassium retention.a mutant of bacillus subtilis 168 (strain 168 kl), which had lost its normal capacity to accumulate k(+), was used to explore the interrelationship between protein and ribonucleic acid (rna) synthesis. in contrast to the wild type, the growth rate of strain 168 kl was markedly dependent on the k(+) concentration in the medium. k(+) uptake in the mutant strain was identical to that in the parent, but the mutant was unable to retain and accumulate k(+). protein synthesis was markedly dependent on ...19684972916
gelatin-induced reversion of protoplasts of bacillus subtilis to the bacillary form: electron-microscopic and physical study.protoplasts of bacillus subtilis plated on sd medium form l colonies in quantitative yield and propagate in the l form indefinitely. l bodies or protoplasts placed in 25% gelatin medium form bacillary colonies. details of the reversion of naked bodies to the walled form are reported. in 25% gelatin medium, reversion begins earlier (about 50% reversion in 4 hr) than the multiplication of bacilli. thus, virtually all the observed bacillary forms are themselves revertants and not the offspring of a ...19684972919
gelatin-induced reversion of protoplasts of bacillus subtilis to the bacillary form: photomicrographic study. 19684972920
preparation of hepatic microsomal particles containing p-450 as the sole heme constituent and absolute spectra of p-450. 19684972922
fractionation by density gradient centrifugation of membranous organellae from synchronous cultures of bacillus megaterium. 19684972944
limitations of thioglycolate broth as a sterility test medium for materials exposed to gaseous ethylene oxide.although ethylene oxide is a reliable sterilizer, the process may be limited by diffusion. thus, situations may exist where microorganisms are protected from the sterilizing gas. it is possible that the exterior of a substance may be sterilized, whereas the interior is not. we investigated three general types of materials in which this limitation of diffusion could occur: the bore of glass and plastic tubing, the center of cotton balls, and plastic adhesive film/paper backing interface. these ma ...19684973064
sporicidal effect of peracetic acid vapor.the sporicidal activity of peracetic acid (paa) vapor at 20, 40, 60, and 80% relative humidity (rh) and 25 c was determined on bacillus subtilis var. niger spores on paper and glass surfaces. appreciable activity occurred within 10 min of exposure to 1 mg of paa per liter and 40% or higher rh. the sporicidal rate decreased from the optimum at 80% rh to a slight effect at 20% rh. spores on an impermeable surface were more difficult to kill than those on a porous one, probably because the cells te ...19684973068
effect of streptomycin on some enzyme systems of bacillus subtilis.streptomycin slightly inhibited lactic and malic dehydrogenases of bacillus subtilis, and inhibited isocitric dehydrogenase to about 60%. the formation of lactic dehydrogenase, glutamic dehydrogenase, alpha-alanine dehydrogenase, and succinic dehydrogenase was stimulated by the antibiotic at a concentration causing 50% inhibition of bacterial growth. streptomycin had practically no influence on the formation of malic dehydrogenase, but the antibiotic produced 48% inhibition of the synthesis of i ...19684973069
dry heat resistance of spores of bacillus subtilis var. niger on kapton and teflon film at high temperatures.to determine parameters that would assure sterility of a sealed seam of film for application in "split-seam entry," spores of bacillus subtilis var. niger were sprayed onto pieces of kapton and teflon film. short-time, high-temperature (200 to 270 c) exposures were made with film pieces between aluminum blocks in a hot-air oven, and the d and z values were determined after subculture of surviving spores. the use of kapton film allowed the study of high temperatures, since it is not heat sealable ...19684973071
[sugar transport in bacillus subtilis]. 19684973098
metabolic conversion of formycin b to formycin a and to oxoformycin b in nocardia interforma. 19684973121
synthesis of tetra-n-phenylalkylkanamycins and their antimicrobial activities. 19684973122
the total synthesis of kanamycin a. 19684973123
cross pathway regulation: effect of histidine on the synthesis and activity of enzymes of aromatic acid biosynthesis in bacillus subtilis.l-histidine and, to a lesser degree, l-phenylalanine at concentrations of 10(-4)m inhibit the growth of leaky mutants (bradytrophs) of bacillus subtilis that are deficient in the synthesis of p-hydroxyphenylpyruvate, the first intermediate specific to tyrosine synthesis. the inhibition can be overcome by growth factor amounts of l-tyrosine and p-hydroxyphenylpyruvate. histidine and phenylalanine are capable of inhibiting the synthesis of tyrosine in several ways, and the major physiological effe ...19684973127
common element in the repression control of enzymes of histidine and aromatic amino acid biosynthesis in bacillus subtilus.single-step mutants of bacillus subtilis derepressed for enzymes of both aromatic amino acid and histidine biosynthesis were isolated. these mutants occur at a frequency of 10(-6) per cell per generation. all histidine enzymes as well as all enzymes of aromatic acid synthesis which were examined are maximally derepressed. this level cannot be repressed by growth on either histidine or tyrosine. some of the structural genes which specify the derepressed enzymes are linked to the aromatic cluster; ...19684973128
the action of dilute alkali on some bacterial cell walls. 19684972218
the resistance of ribonucleic acid polymerase to proteolytic attack during transcription in vitro. 19684972228
sporulation in bacillus subtilis. the role of exoprotease.1. intracellular turnover of protein was measured in wild-type bacillus subtilis, which produces exoprotease at stage i in the sporulation process. protein is degraded at a rate of 8-10%/hr. 2. as a result of this turnover, the proteins of the mother cell are extensively degraded and resynthesized by about 6hr., so that the later stages of spore formation occur in a cytoplasm containing mainly ;new' protein. 3. the same protease appears to be responsible both for the intracellular turnover of pr ...19684972253
sporulation in bacillus subtilis. antigenic changes during spore formation.1. antisera, prepared against extracts of cells and spores of bacillus subtilis, were used in immunoelectrophoretic studies of the changes occurring in cell extracts during the course of spore formation. 2. at least 15 antigens could be detected in vegetative-cell extracts by the antiserum prepared against cell extracts and at least seven could be demonstrated in spore extracts by the homologous antiserum. 3. cross-absorption studies showed that two of these antigens were probably completely spe ...19684972254
sporulation in bacillus subtilis. biochemical changes.1. during the course of growth and sporulation of bacillus subtilis in chemically defined media, measurements were made of 16 different parameters, including the specific activities of nine intracellular enzymes. 2. towards the end of exponential growth, proteolytic activity increased and reached a maximum soon after growth ceased. 3. in the presence of an excess of phosphate the specific activity of alkaline phosphatase increased fivefold at the end of exponential growth. 4. the specific activi ...19684972255
sporulation in bacillus subtilis. morphological changes.1. when bacillus subtilis was grown in a medium in which sporulation occurred well-defined morphological changes were seen in thin sections of the cells. 2. over a period of 7.5hr. beginning 2hr. after the initiation of sporulation the following major stages were observed: axial nuclear-filament formation, spore-septum formation, release of the fore-spore within the cell, development of the cortex around the fore-spore, the laying down of the spore coat and the completion of the corrugated spore ...19684972256
[comparative radiorespirometric study of mineralization in the soil of glucose labeled (1), (2), (3-4), (6) and (u)]. 19684972286
non-coordinate regulation in 5-methyl tryptophan-resistant mutants of bacillus subtilis. 19684972288
effect of pactamycin on methylation of rna and protein synthesis. 19684972327
a time-dependent activation of threonine deaminase. 19684972611
a mutant of bacillus subtilis producing ultraviolet-sensitive spores. 19684972612
x-ray diffraction study of spo-1 dna. 19684972651
release of dna from phage on the top of sucrose gradients. 19684972652
studies on microbial degradation of cephalosporin c derivatives. ii. on the degradation of several derivatives and the activities of some strains isolated from patients. 19684972705
the total synthesis of kanamycin b. 19684972706
regulation of purine ribonucleotide synthesis by end product inhibition. i. effect of purine nucleotides on inosine-5'-phosphate dehydrogenase, xanthosine-5'-phosphate aminase and adenylosuccinate lyase of bacillus subtilis. 19684972708
chemical derivation of antibiotics active against resistant bacteria. 19684972718
experimental anticancer studies. xxxvi. the effect of 2-(2-hydroxyphenyliminomethyl)-4-n-hexylphenol on ribonucleic acid synthesis and energy metabolism in bacillus subtilis. 19684975995
the relationship between irregularities in the double-helical structure of bacillus subtilis and bacillus brevis dnas and their oscillopolarographic behaviour. 19684975946
related base sequences in the dna of simple and complex organisms. i. dna-dna duplex formation and the incidence of partially related base sequences in dna. 19684975777
related base sequences in the dna of simple and complex organisms. ii. the interpretation of dna-rna hybridization studies with mammalian nucleic acids. 19684975778
[effect of transforming dna on irradiated competent cells of bacillus subtilis]. 19684975906
the distribution of 3h-bleomycin in mouse tissue. 19684975612
isozymes of human red cell glucose-6-phosphate dehydrogenase. 19684975692
[biochemical complementation of the ncf- mutants of bacillus subtilis and staphylococcus aureus]. 19684975145
ultrastructural examination of the squid giant axons perfused intracellularly with protease. 19684975159
observations of single phage-infected cells of bacillus subtilis. 19684975160
a new antibiotic, 1-(p-hydroxyphenyl)-2,3-diisocyano-4-(p-methoxyphenyl)-buta-1,3-diene. i. isolation and biological properties. (studies on antiviral and antitumor antibiotics. ii). 19684975360
the genetic code after the excitement. 19684975305
[studies on the mechanism of biosynthesis and accumulation of dipicolinic acid in spore-forming bacteria. i. physical and chemical properties of an active fraction catalyzing synthesis of dipicolinic acid from the diketopimelate-nh3 complex]. 19684975434
[anti-inflammatory action of bacillus sublitis protease, with special reference to enzymatic activity and relation between anti-inflammatory action and substrate specificity]. 19684975443
structure-biological activities relationships among the leucomycins and their derivatives. 19684975519
studies on antibiotics produced from kitasatoa kauaiensis sp. nov. 19684975520
amidinomycin from streptomyces kasugaensis producing kasugamycin. 19684975521
[macromolecular chantes during sporulation of bacillus subtilix]. 19684973874
penicillin production and its mode of inheritance in aspergillus nidulans. 19684973904
broadening by acridine orange of the thermal transition of dna. 19684973905
on the c-terminal amino acid of bacterial alpha-amylase. 19684974518
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