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genomic analysis of bartonella identifies type iv secretion systems as host adaptability factors.the bacterial genus bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. we determined the comp ...200718037886
a case of fatal disseminated bartonella henselae infection (cat-scratch disease) with encephalitis.cat-scratch disease resulting from bartonella henselae infection is usually a benign, self-limited process in immunocompetent children. even the rare cases associated with neurologic manifestations are not generally fatal. we report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. to our knowledge, this finding has not b ...200717922599
bartonella endocarditis in complex congenital heart disease.bartonella species are an important cause of culture-negative endocarditis, with recognized risk factors of alcoholism, homelessness, cat exposure, and pre-existing valvular disease. we report a case of bartonella henselae endocarditis in a 36-year-old woman with complex congenital heart disease who presented with a 7-month history of hemolytic anemia, leukocytoclastic vasculitis, and recurrent fevers. transesophageal echocardiogram revealed vegetations on the patient's native aortic valve and i ...200718377522
[persistent bartonella infection: epidemiological and clinical implications].bartonella are gram-negative hemotropic bacteria that infect a wide range of mammals. at least 14 bartonella species or subspecies have been reported to be pathogenic for humans and animals. wild and domestic animals represent a large reservoir. reservoir species usually display chronic bacteremia. this explains some aspects of the epidemiology of these infections, and especially vector-borne transmission. the molecular mechanisms of persistent infection have clinical consequences both for occas ...200718402163
molecular evidence of bartonella dna in ixodid ticks in czechia.we report the development of a novel method for detection of bartonella dna in ixodid ticks. the assay is based on a specific amplification of a part of 16s rrna gene and 16s-23s rrna intergenic spacer region of bartonella sp. by nested pcr and southern blot hybridization with specific dna probe; the method is highly sensitive and specific. the screening of 327 unfed ticks collected in different urban and suburban areas of czechia in 2003-2005 revealed the presence of bartonella dna in four ixod ...200718298048
detection of bartonella henselae in the blood of 2 adult horses.bartonella spp. are emerging zoonotic agents that have been found in a wide variety of domestic animals and wildlife and cause a number of clinical syndromes. bartonella sp. infection has been identified in a growing number of animal species, including cats, rodents, porpoises, and canids, but has not been reported in horses.200818346149
a bioinformatic approach to understanding antibiotic resistance in intracellular bacteria through whole genome analysis.intracellular bacteria survive within eukaryotic host cells and are difficult to kill with certain antibiotics. as a result, antibiotic resistance in intracellular bacteria is becoming commonplace in healthcare institutions. owing to the lack of methods available for transforming these bacteria, we evaluated the mechanisms of resistance using molecular methods and in silico genome analysis. the objective of this review was to understand the molecular mechanisms of antibiotic resistance through i ...200818619818
abscess-forming lymphadenopathy and osteomyelitis in children with bartonella henselae infection.bartonella henselae is the agent of cat-scratch disease (csd), a chronic lymphadenopathy among children and adolescents. a systemic infection is very rare and most of these cases are found in patients with immunodeficiency. here, cases involving four children of 6-12 years of age are reported. three of the children had an abscess-forming lymphadenopathy and surrounding myositis in the clavicular region of the upper arm. the diagnosis was made serologically and, in one case, using eubacterial uni ...200818349375
first report of bartonella quintana endocarditis in japan.bartonella (rochalimaea) species are increasingly recognized as a cause of endocarditis, but the total number of cases remains low. especially, bartonella quintana endocarditis is very rare and there have been no reports in japan. a 66-year-old man was hospitalized because of dyspnea and fever. an echocardiogram showed severe mitral valve regurgitation, mild aortic valve regurgitation, and echogenic masses on the mitral and aortic valve. six sets of blood cultures were negative. replacement of t ...200818503234
[cat-scratch disease localisation in the parotid gland].cat scratch disease is an infection due to bartonella henselae. it is one of the principal causes of benign chronic adenopathy in children or young adults.200818533210
analysis of a novel insect cell culture medium-based growth medium for bartonella species.human- and animal-pathogenic bartonella species are fastidious and slow-growing bacteria difficult to isolate and cultivate. we describe a novel, easy-to-prepare liquid medium for the fast and reliable growth of several bartonella spp. that does not affect bacterial protein expression patterns or interactions with host cells.200818567689
[cat scratch disease and other human infections caused by bartonella species].the different bartonella species can cause various human infections such as cat scratch disease, chronic bacteremia (homeless patient with nonspecific symptom), endocarditis, bacillary angiomatosis, peliosis, and carrion's disease. diagnostic approaches include serology, culture and molecular approaches. pcr is especially useful on lymph nodes biopsies from patients with cat-scratch disease and on valvular samples taken from culture-negative endocarditis. serology exhibits a very high sensitivit ...200818578430
[the diagnosis of cat-scratch-disease-associated adenitis: diagnostic value of serology and polymerase chain reaction].the diagnosis of cat scratch disease (csd) associated adenitis relies classically on the association of clinical, epidemiological and bacteriological criteria. the polymerase chain reaction (pcr) looks like a more competitive diagnostic trial than serology. we evaluated the sensitivity, specificity and predictive positive and negative values of serology in routine diagnosis of csd. a retrospective study over five years was led among patients presenting a suspicion of csd and having a serology an ...200818842353
prevalence and genetic diversity of bartonella species isolated from wild rodents in japan.here, we describe for the first time the prevalence and genetic properties of bartonella organisms in wild rodents in japan. we captured 685 wild rodents throughout japan (in 12 prefectures) and successfully isolated bartonella organisms from 176 of the 685 rodents (isolation rate, 25.7%). those bartonella isolates were all obtained from the rodents captured in suburban areas (rate, 51.8%), but no organism was isolated from the animals captured in city areas. sequence analysis of rpob and glta r ...200818606803
bartonella henselae survives after the storage period of red blood cell units: is it transmissible by transfusion?bartonella henselae is the agent of cat scratch disease and bacillary angiomatosis. blood donors can be asymptomatic carriers of b. henselae and the risk for transmission by transfusion should be considered. the objective of this study was to demonstrate that b. henselae remains viable in red blood cell (rbc) units at the end of the storage period. two rbc units were split into two portions. one portion was inoculated with b. henselae and the other was used as a control. all units were stored at ...200818937735
inguinal lymphadenopathy due to bartonella henselae.the bacterium bartonella henselae causes cat scratch disease, a self-limited zoonotic disease which is common among children and adolescents. the most typical clinical presentation is a regional lymphadenopathy that commonly involves only a single node of cervical and axillary lymph nodes. inguinal localization is rarely described. we report a case of a 35-year-old caucasian male complaining of a painless right inguinal mass and slight fever. a diagnosis of bartonella henselae infection was made ...200818622149
bartonella henselae in captive and hunter-harvested beluga (delphinapterus leucas).previously, we reported the isolation of bartonella henselae from the blood of harbor porpoises (phocoena phocoena) and loggerhead sea turtles (caretta caretta) from the north carolina coast. hematologic, pathologic, and microbiologic findings surrounding the death of a juvenile captive beluga in vancouver initiated an outbreak investigation designed to define the molecular prevalence of bartonella infection in belugas. using polymerase chain reaction analyses targeting the intergenic spacer reg ...200818957643
seroprevalence of bartonella henselae antibodies in blood donors in crete. 200818609206
the prevalence of bartonella, hemoplasma, and rickettsia felis infections in domestic cats and in cat fleas in ontario.the prevalence of persistent bacteremic bartonella spp. and hemoplasma infections was determined in healthy pet cats in ontario. blood samples from healthy cats sent to a diagnostic laboratory for routine health assessment over the course of 1 y were tested for bartonella spp. using both polymerase chain reaction (pcr) and blood culture, and for the presence of hemoplasma by pcr. the overall prevalence of bartonella spp. by pcr and by culture combined was 4.3% (28/646) [3.7% (24/646) bartonella ...200819086373
myocarditis due to bartonella henselae. 200819088543
possible donor-recipient bartonellosis transmission in a pediatric liver transplant.bartonella henselae is the causative agent of cat-scratch disease and other disorders, including hepatosplenic granulomatosis. this infection has only rarely been reported after solid organ transplantation, where it can mimic the more common post-transplant lymphoproliferative disease. here we present a case of asymptomatic b. henselae hepatic and lymph nodal granulomatosis in a pediatric patient who had received orthotopic liver transplant 2 months before; we hypothesize that the causative agen ...200818651873
serological evidence for the association of bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy.arrhythmogenic right ventricular cardiomyopathy (arvc) is an important cause of sudden death in young adults. on the basis of histopathological findings its pathogenesis may involve both a genetic origin and an inflammatory process. bartonella henselae may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death.200818666174
the head of bartonella adhesin a is crucial for host cell interaction of bartonella henselae.human pathogenic bartonella henselae cause cat scratch disease and vasculoproliferative disorders (e.g. bacillary angiomatosis). expression of bartonella adhesin a (bada) is crucial for bacterial autoagglutination, adhesion to host cells, binding to extracellular matrix proteins and proangiogenic reprogramming via activation of hypoxia inducible factor (hif)-1. like the prototypic yersinia adhesin a, bada belongs to the class of trimeric autotransporter adhesins and is constructed modularly cons ...200818627378
incidence of various tick-borne microorganisms in rodents and ticks of central slovakia.in this study, we detected rickettsia helvetica, candidatus midichloria mitochondrii, anaplasma phagocytophilum, ehrlichia muris, candidatus neoehrlichia mikurensis, and bartonella sp. infections in wild rodents and ticks collected from the vegetation of central slovakia. the microorganisms were identified by pcr and sequencing. yellow-necked mice (apodemus flavicollis) were infected with e. muris and bartonella sp., while ticks ixodes ricinus collected from the vegetation were infected with r. ...200818999892
ocular bartonella infections. 200818645403
isolation of bartonella species from rodents in taiwan including a strain closely related to 'bartonella rochalimae' from rattus norvegicus.an increasing number of bartonella species originally isolated from small mammals have been identified as emerging human pathogens. during an investigation of bartonella infection in rodent populations carried out in taiwan in 2006, a total of 58 rodents were tested. it was determined that 10.3 % (6/58) of the animals were bartonella bacteraemic. after pcr/rflp analysis, four isolates were identified as bartonella elizabethae and one isolate as bartonella tribocorum. however, there was one speci ...200819018019
hemoplasma infection in hiv-positive patient, brazil.hemotrophic mycoplasmas infect a variety of mammals. although infection in humans is rarely reported, an association with an immunocompromised state has been suggested. we report a case of a mycoplasma haemofelis-like infection in an hiv-positive patient co-infected with bartonella henselae.200819046522
bartonella henselae antibodies after cat bite. 200819046527
human case of bartonella alsatica lymphadenitis. 200819046532
bartonella spp. and rickettsia felis in fleas, democratic republic of congo. 200819046544
pathogen screening and bionomics of lutzomyia apache (diptera: psychodidae) in wyoming, usa.phlebotomine sand flies are vectors of bacteria, parasites, and viruses. lutzomyia apache, a north american sand fly, was incriminated as a vector of vesicular stomatitis viruses (vsv) due to overlapping ranges of the sand fly and recent outbreaks of vsv. we report on the discovery of 2 populations of l. apache in wyoming from albany and fremont counties. we attempted to isolate vsv and phleboviruses from sand flies from albany county and screened select flies by polymerase chain reaction for ba ...200818939699
molecular screening of bartonella species in rodents from south western spain.rodents (87 mus spretus and 10 rattus norvegicus) collected in a suburban area of seville (andalusia, spain) between september 2003 and april 2004 were tested by polymerase chain reaction for the presence of bartonella dna using primers amplifying a fragment of the 16s/23s rrna internal transcribed spacer (its). sequence analyses of the its of these bartonella demonstrated that rodents in this region harbored at least three strains: two bartonella genotypes detected in m. spretus, which clustere ...200818620508
balb/c mice resist infection with bartonella bacilliformis.bartonellosis due to bartonella bacilliformis is a highly lethal endemic and sometimes epidemic infectious disease in south america, and a serious public health concern in perú. there is limited information on the immunologic response to b. bacilliformis infection. the objective of this research was to produce experimental infection of balb/c mice to b. bacilliformis inoculation.200818957122
hepatosplenic cat-scratch fever with seropositivity for bartonella quintana? 200818992392
cat scratch disease presenting as acute encephalopathy.an unusual case of primary meningo-encephalitis followed by partial complex seizure in a 9-year-old boy was found to be a symptom of cerebral bartonella henselae infection or cat scratch disease. despite one clinical relapse at 4 weeks post-presentation, he remained seizure free on carbamazepine for one year. six months after stopping carbamazepine, however, he developed deja vu phenomena and absence seizures with eeg abnormality. restarting carbamazepine improved his symptoms.200818843081
the janus face of bartonella quintana recognition by toll-like receptors (tlrs): a review.bartonella quintana (b. quintana) is a facultative, intracellular bacterium, which causes trench fever, chronic bacteraemia and bacillary angiomatosis. little is known about the recognition of b. quintana by the innate immune system. in this review, we address the impact of toll-like receptors (tlrs) on the recognition of b. quintana and the activation of the host defense. when experimental models using human mononuclear cells, transfected cho cells, or tlr2-/- and tlr4-/- mice were used, differ ...200818775802
microbial culture of blood samples and serologic testing for bartonellosis in cats with chronic rhinosinusitis.to assess the role of bartonella spp in chronic rhinosinusitis (crs) by determining detection rates for the organism by serologic testing and microbial culture of blood samples for bartonella spp in cats with crs and control cats (cats with other nasal diseases, cats with systemic illnesses, and healthy cats).200818828717
bartonella endocarditis mimicking adult still's disease.we describe the case of a 39-year-old caucasian woman who was admitted to the university hospital of antwerp with a clinical picture suggestive of adult still's disease. even though a transoesophageal echocardiography showed endocarditis of the aortic valve, blood cultures remained negative. additional serological testing revealed a positive result for bartonella henselae. histology of the supraclavicular lymph node showed a reactive lymph node with a positive polymerase chain reaction (pcr) for ...200818714850
p26-based serodiagnosis for bartonella spp. infection in cats.bartonella henselae p26 has been identified as an immunodominant antigen expressed during feline infection. we used antisera from cats experimentally infected with b. henselae (n = 6), b. clarridgeiae (n = 4), or b. koehlerae (n = 2) and from a sample of naturally infected cats (b. henselae, n = 34; b. clarridgeiae, n = 1) to evaluate recombinant p26 (rp26) as a serodiagnostic antigen. immunoblots using antisera from cats infected with b. henselae and b. clarridgeiae reacted strongly with rp26, ...200818724780
simultaneous presence of two different copies of the 16s rrna gene in bartonella henselae.bartonella henselae is an emerging pathogen of increasing medical significance. previous investigations have revealed two different 16s rrna gene variants among b. henselae isolates, resulting in delineation of the b. henselae population into 16s rna type i and type ii isolates. while studying 191 b. henselae isolates by multi-locus sequence typing (mlst) we detected three isolates that could not be assigned to a distinct 16s rna type upon direct sequencing because of ambiguous nucleotides in a ...200818757822
[microbiological diagnosis of emerging bacterial pathogens: anaplasma, bartonella, rickettsia, and tropheryma whipplei].ehrlichia/anaplasma, bartonella, rickettsia and tropheryma whipplei (formerly called whippelii) are fastidious bacterial organisms, considered the causative agents of potentially severe emerging and re-emerging diseases with repercussions on public health. the recent availability of advanced molecular biology and cell culture techniques has led to the implication of many of these species in human pathologies. these issues are extensively covered in number 27 of the seimc microbiological procedur ...200819100178
[ocular bartonellosis in an hiv-hvc coinfected patient].bartonella henselae is the etiologic agent of the cat scratch disease and in immunocompromised patients, of bacillary angiomatosis and peliosis hepatis. less often, ocular complications associated with b. henselae infection have been reported in immunocompetent patients and five times in hiv-infected patients. we report the case of a 42-year-old woman, coinfected by hiv-hcv, presenting with cirrhosis, who owned a cat and was hospitalized for bilateral loss of visual acuity. ophthalmologic examin ...200818706780
[interaction of bacteria of the genus bartonella with the host: inhibition of apoptosis, induction of proliferation, and formation of tumors].the bacteria of the genus bartonella are the causative agents for earlier not diagnosed or re-emergent diseases of the humans, danger of which increases in relation with increasing number of persons with the disturbed immune status. bartonellae are intracellular parasites, the places of their habitation in the humans and animals are the endothelial cells of blood vessels and erythrocytes. the modern data concerning major factors of the bartonellae virulence and host-bacteria interactions were co ...200818763333
[prevalence igg antibodies against bartonella henselae in children with lymphadenopathy].bartonella henselae is a cat scratch disease's etiological agent which is usually manifestated as regional lymphadenopathy. in differential diagnosis of lymphadenopathy infections about etiology b. henselae are rarely taken into consideration. enlargement of lymph nodes observed in children more often than in adults are caused by bacterial, virus or parasitic factors. in this study immunoglobulines g class antibodies to b. henselae were determined among children with limphadenopathy. at 53 child ...200819209738
infection-associated type iv secretion systems of bartonella and their diverse roles in host cell interaction.type iv secretion systems (t4sss) are transporters of gram-negative bacteria that mediate interbacterial dna transfer, and translocation of virulence factors into eukaryotic host cells. the alpha-proteobacterial genus bartonella comprises arthropod-borne pathogens that colonize endothelial cells and erythrocytes of their mammalian reservoir hosts, thereby causing long-lasting intraerythrocytic infections. the deadly human pathogen bartonella bacilliformis holds an isolated position in the barton ...200818489724
[cat scratch disease: a diagnosis to be aware of!].subacute cervical lymphadenopathy among young adults may be of an infectious or malignant aetiology. we report two cases of young males with chronic cervical lymphadenopathy. a diagnosis of cat scratch disease (csd) was made by serological and molecular studies. csd is one of the most frequent infectious lymphadenopathies among young people. diagnosis of csd is dependent on clinical, epidemiological, molecular and histological criteria. the detection of antibodies to bartonella henselae and the ...200818777770
infective endocarditis due to bartonella quintana: a challenging diagnostic entity.bartonella quintana is a gram-negative microorganism, which may lead to infective endocarditis especially in compromised patients. the major concern about this pathogen is the diagnosis and detection. furthermore, the treatment of the infection has been a challenge for physicians. in this report, we present a 71-year-old patient with bartonella quintana aortic valve endocarditis from the view of diagnosis and treatment aspects.200818795592
visceral involvement in an immunocompetent male: a rare presentation of cat scratch disease.we report a case of an adult, immunocompetent male with lymphadenopathy of both groins, para-aortal lymph nodes and multiple lesions in the spleen. a neoplasm was excluded by histology of the largest lymph node from the left groin. the diagnosis of cat-scratch disease (csd ) became apparent when serological testing for bartonella henselae showed to be positive. a review of literature shows that disseminated (visceral) infection is a rare presentation of csd.200818424863
structure of the head of the bartonella adhesin bada.trimeric autotransporter adhesins (taas) are a major class of proteins by which pathogenic proteobacteria adhere to their hosts. prominent examples include yersinia yada, haemophilus hia and hsf, moraxella uspa1 and a2, and neisseria nada. taas also occur in symbiotic and environmental species and presumably represent a general solution to the problem of adhesion in proteobacteria. the general structure of taas follows a head-stalk-anchor architecture, where the heads are the primary mediators o ...200818688279
[bartonella henselae and its infections].in recent years the number of identified bartonella species has increased rapidly and several species in bartonella genus isolated from various mammalian reservoirs were recognized as zoonotic agents in humans. three bartonella species are considered to be pathogenic for humans; b. henselae, b. quintana and b. bacilliformis. b. henselae causes asymptomatic intraerythrocytic bacteraemia in the feline reservoir host and is the most important zoonotic species as the cause of human diseases includin ...200818444576
severe occlusive vasculitis as a complication of cat scratch disease.the purpose of this communication is to report a severe occlusive vasculitis as a complication of cat scratch.200818454406
failure to identify an association between serologic or molecular evidence of bartonella infection and idiopathic rhinitis in dogs.to determine whether infection with or exposure to bartonella spp was associated with idiopathic rhinitis in dogs.200818710315
culture-negative infectious endocarditis caused by bartonella spp.: 2 case reports and a review of the literature.bartonella spp. are rare pathogens in humans and were recently recognized as important causative agents of culture-negative endocarditis. here, we describe the 1st 2 documented cases of culture-negative endocarditis due to bartonella henselae and bartonella quintana encountered in a single hospital in germany. infection of the heart valve tissue was detected by broad-range polymerase chain reaction (pcr) and further confirmed by serologic testing. in particular, acute b. henselae infection with ...200818455348
microbial pathogens in ticks, rodents and a shrew in northern gyeonggi-do near the dmz, korea.a total of 1,618 ticks [420 individual (adults) and pooled (larvae and nymphs) samples], 369 rodents (apodemus agrarius, rattus norvegicus, tscherskia triton, mus musculus, and myodes regulus), and 34 shrews (crocidura lasiura) that were collected in northern gyeonggi-do near the demilitarized zone (dmz) of korea during 2004-2005, were assayed by pcr for selected zoonotic pathogens. from a total of 420 individual and pooled tick dna samples, anaplasma (a.) phagocytophilum (16), a. platys (16), e ...200818716449
bartonella species detection in captive, stranded and free-ranging cetaceans.we present prevalence of bartonella spp. for multiple cohorts of wild and captive cetaceans. one hundred and six cetaceans including 86 bottlenose dolphins (71 free-ranging, 14 captive in a facility with a dolphin experiencing debility of unknown origin, 1 stranded), 11 striped dolphins, 4 harbor porpoises, 3 risso's dolphins, 1 dwarf sperm whale and 1 pygmy sperm whale (all stranded) were sampled. whole blood (n = 95 live animals) and tissues (n = 15 freshly dead animals) were screened by pcr ( ...200818721502
cat-scratch disease of the head and neck in a pediatric population: surgical indications and outcomes.to identify the presentation of pediatric patients with head and neck manifestations of cat-scratch disease, one of the most common causes of subacute or chronic lymphadenitis in children, and to determine surgical indications and outcomes.200818722212
macular hole following bartonella henselae neuroretinitis.to report a case of macular hole secondary to bartonella henselae neuroretinitis.200818465733
laboratory maintenance of bartonella quintana.trench fever is the common name for the acute febrile syndrome associated with a bartonella quintana bacterial infection. the focus of this unit is to describe reliable methods for cultivation and cryopreservation of b. quintana and can be applied to cultivation and preservation of all bartonella. detailed recipes for preparation of three types of semisolid media are also included.200818729057
bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs. 200818466250
preventing and controlling emerging and reemerging transmissible diseases in the homeless.homelessness is an increasing public health problem. because of poor living conditions and limited access to healthcare systems, homeless persons are exposed to many communicable infections. we summarize the intervention measures reported to be efficient for the control and the prevention of common transmissible infections among homeless populations. evidence suggests that appropriate street- or shelter-based interventions for targeted populations are the most efficient methods. depending on the ...200818760000
[cat scratch disease]. 200818470500
molecular evidence for bartonella spp. in cat and dog fleas from germany and france.nine hundred and fifty-two fleas were collected from 148 cats and 133 dogs at 18 widely distributed geographic locations in germany and france and examined for the presence of six different bartonella spp. (bartonella bacilliformis, bartonella clarridgeiae, bartonella elizabethae, bartonella henselae, bartonella quintana, bartonella vinsonii subsp. berkhoffii) by pcr. thirty-five specimens (3.7%) tested positive for either b. henselae (14 positive fleas) or b. clarridgeiae (21 positive fleas). d ...200818489542
native valve endocarditis due to bartonella henselae in an immunocompetent man.culture-negative endocarditis accounts for 2.5-31% of all endocarditis cases and remains a diagnostic and therapeutic challenge. bartonella spp. has only recently been recognized as an important cause of culture-negative endocarditis. we report a case of bartonella henselae endocarditis occurring in an immunocompetent man who owned a cat and had previously been diagnosed with valvulopathy. diagnosis was made only after prolonged diagnostic work-up with serology and with pcr and subsequent sequen ...200818500601
use of bartonella adhesin a (bada) immunoblotting in the serodiagnosis of bartonella henselae infections.bartonella henselae causes a variety of human diseases (e.g. cat scratch disease and the vasculoproliferative disorders, bacillary angiomatosis and peliosis hepatis). the laboratory diagnosis of b. henselae infections is usually based on the detection of anti-b. henselae antibodies by an indirect immunofluorescence assay (ifa) which, unfortunately, suffers from a significant amount of cross-reactivity and hence is prone to deliver false-positive results. in this pilot study, we evaluated the use ...200818501673
giant pyogenic granuloma of the thigh: a case report.pyogenic granuloma or lobular capillary hemangioma remains an etiopathological enigma, with trauma, inflammatory and infectious agents being the commonest suspected causative agents. these lesions affect mucous membranes of the upper aero-digestive tract, and skin. hiv patients diagnosed with pyogenic granuloma present with multiple lesions, caused by bartonella spp.200818377654
immune thrombocytopenic purpura as a complication of bartonella henselae infection.immune thrombocytopenic purpura is an infrequent yet well-recognized complication of viral infections, such as mumps, rubella, varicella, cytomegalovirus, parvovirus and infectious monunucleosis by epstein-barr virus. some recent studies have described a possible association between henoch-schonlein purpura, a non-thrombocytopenic purpura, and seropositivity for bartonella henselae, but in the literature only sporadic case reports have described a severe immune thrombocytopenic purpura as a comp ...200818622151
vector transmission of bartonella species with emphasis on the potential for tick transmission.bartonella species are gram-negative bacteria that infect erythrocytes, endothelial cells and macrophages, often leading to persistent blood-borne infections. because of the ability of various bartonella species to reside within erythrocytes of a diverse number of animal hosts, there is substantial opportunity for the potential uptake of these blood-borne bacteria by a variety of arthropod vectors that feed on animals and people. five bartonella species are transmitted by lice, fleas or sandflie ...200818380649
low sensitivity of bartonella henselae pcr in serum samples of patients with cat-scratch disease lymphadenitis. 200818628513
bartonella sp. bacteremia in patients with neurological and neurocognitive dysfunction.we detected infection with a bartonella species (b. henselae or b. vinsonii subsp. berkhoffii) in blood samples from six immunocompetent patients who presented with a chronic neurological or neurocognitive syndrome including seizures, ataxia, memory loss, and/or tremors. each of these patients had substantial animal contact or recent arthropod exposure as a potential risk factor for bartonella infection. additional studies should be performed to clarify the potential role of bartonella spp. as a ...200818632903
coinfection with four genera of bacteria (borrelia, bartonella, anaplasma, and ehrlichia) in haemaphysalis longicornis and ixodes sinensis ticks from china.we studied coinfection with four genera of bacteria--borrelia, bartonella, anaplasma, and ehrlichia--in ticks collected between december 2005 and november 2006 from zhejiang province and liaoning province. four hundred fifty haemaphysalis longicornis and 86 ixodes sinensis ticks were collected and divided into 236 groups. polymerase chain reaction (pcr) or nested pcr was used to detect the bacteria. the amplicons were sequenced and compared to published sequences. phylogenic analysis was perform ...200818637722
serum cardiac troponin i concentration in dogs with ehrlichiosis.ehrlichiosis is a multisystemic disease with the potential to cause cardiomyocyte injury in naturally infected dogs.200818638021
cat scratch disease complicated with aseptic meningitis and neuroretinitis.cat scratch disease (csd) is a self limited condition characterized by fever, lymph node enlargement and less often eye involvement. central nervous system involvement by bartonella henselae infection is possibly an important cause of morbidity; its role as an agent of aseptic meningitis is unknown. we report a case of a 40 years-old man with csd accompanied by aseptic meningitis and neuroretinitis. serum indirect immmunofluorescence (ifi) assays for b. henselae were positive and the cerebrospin ...200818641856
domain annotation of trimeric autotransporter adhesins--dataa.trimeric autotransporter adhesins (taas), such as yersinia yada, neisseria nada, moraxella uspas, haemophilus hia and bartonella bada, are important pathogenicity factors of proteobacteria. their high sequence diversity and distinct mosaic-like structure lead to difficulties in the annotation of their sequences. these stem from the large number of short repeats, the presence of compositionally unusual coiled-coils, fuzzy domain boundaries and regions of seemingly low sequence complexity.200818397894
bartonella species antibodies and dna in cerebral spinal fluid of cats with central nervous system disease.bartonella species infection is associated with central nervous system (cns) disease in some humans and cats but the diagnosis is difficult to confirm with blood or serum test results. in this retrospective study of 100 client-owned cats, serum and cerebral spinal fluid (csf) were assayed for bartonella species igg antibodies and csf was assayed for bartonella species dna. bartonella species igg antibodies were detected in serum of 36 cats, bartonella species c-values>1 (suggesting antibody prod ...200818400536
characterization of bartonella strains isolated from black-tailed prairie dogs (cynomys ludovicianus).thirty bartonella strains were isolated from the blood of black-tailed prairie dogs (cynomys ludovicianus) from boulder county, colorado, usa. the bacteria appeared as small, fastidious, aerobic, gram-negative rods. the partial sequences of the citrate synthase gene (glta) demonstrated five unique genetic variants. phylogenetic analysis based on sequences of glta, 16s rrna, rpob, ftsz, and ribc showed that the black-tailed prairie dog-related bartonella variants comprise a distinct monophyletic ...200818237261
[ocular bartonellosis: report of three clinical cases].the characteristic clinical presentation of cat scratch disease is subacute regional lymphadenopathy; nevertheless, 5-25% of bartonella henselae infections may present an atypical or systemic form, with potential eye involvement. we describe three clinical cases of ocular bartonellosis in two adolescents and one young adult, who had close contact with cats; all of them presented persistent fever ranging from 15 to 21 days, and two of them developed a sudden unilateral loss of visual acuity assoc ...200818273527
rickettsial seroepidemiology among farm workers, tianjin, people's republic of china.high seroprevalence rates for anaplasma phagocytophilum (8.8%), coxiella burnetii (6.4%), bartonella henselae (9.6%), and rickettsia typhi (4.1%) in 365 farm workers near tianjin, people's republic of china, suggest that human infections with these zoonotic bacteria are frequent and largely unrecognized. demographic features of seropositive persons suggest distinct epidemiology, ecology, and risks.200818507907
high prevalence of fastidious bacteria in 1520 cases of uveitis of unknown etiology.the etiologic evaluation of uveitis is frequently unsuccessful when noninvasive methods are used. we conducted a prospective study to evaluate systematic screening for pathogens of uveitis. all patients with uveitis referred to the participating tertiary ophthalmology departments from january 2001 to september 2007 underwent intraocular and serum specimen collection. the standardized protocol for laboratory investigations included universal polymerase chain reaction (pcr)-based detection of any ...200818520326
lymphadenopathy in a novel mouse model of bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta.in immunocompetent humans, cat scratch disease (csd) is elicited by the gram-negative bacterium bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood. here, we describe a novel mouse model of bartonella-induced csd-like disease that allowed us to investigate the mechanisms leading to lymphadenopathy in vivo. in wild-type mice, a subcutaneous inoculation of either viable or inactivated b. henselae led to a strong swelling of ...200818292236
search for borrelia burgdorferi in kidneys of dogs with suspected "lyme nephritis"."lyme nephritis" is a poorly characterized condition associated with proteinuria and often fatal renal failure in dogs with serological evidence of infection with borrelia burgdorferi.200818564223
factors associated with the occurrence of epistaxis in natural canine leishmaniasis (leishmania infantum).canine leishmaniasis (canl) is a common cause of epistaxis in dogs residing in endemic areas. the pathogenesis of canl-associated epistaxis has not been fully explored because of the limited number of cases reported so far.200818564224
bartonella henselae: first reported isolate in a human in thailand.this is the first reported case of bacillary angiomatosis associated with bartonella henselae in thailand. the clinical, pathological, and microbiological findings are presented. the bacterium was isolated from a biopsy of skin lesions obtained on admission and identified by cellular morphology, characteristics of colonies on chocolate agar, extensive biochemical tests and 16s ribosomal dna sequencing.200818567451
serological evidence of bartonella henselae infection in healthy people in catalonia, spain.cat scratch disease (csd), bacillary angiomatosis, hepatic peliosis and some cases of bacteraemia, endocarditis, and osteomyelitis are directly caused by some species of the genus bartonella. the purpose of this study was to determine the prevalence of igg antibodies against bartonella henselae in healthy people and to identify the epidemiological factors involved. serum samples from 218 patients were examined by indirect immunofluorescence assay (ifa). significance levels for univariate statist ...200818294428
feline bartonellosis and cat scratch disease.bartonella species are important emerging zoonotic pathogens. transmission of these organisms in nature may be much more complex than is currently appreciated. cats can be infected with five bartonella species, including, bartonella henselae, bartonella clarridgeae, bartonella bovis, bartonella koehlerae and bartonella quintana. in addition to cats, numerous domestic and wild animals, including bovine, canine, human, and rodent species can serve as chronically infected reservoir hosts for variou ...200818295347
human bartonellosis: seroepidemiological and clinical features with an emphasis on data from brazil - a review.bartonellae are fastidious gram-negative bacteria that are widespread in nature with several animal reservoirs (mainly cats, dogs, and rodents) and insect vectors (mainly fleas, sandflies, and human lice). thirteen species or subspecies of bartonella have been recognized as agents causing human disease, including b. bacilliformis, b. quintana, b. vinsonii berkhoffii, b. henselae, b. elizabethae, b. grahamii, b. washoensis, b. koehlerae, b. rocha-limaea, and b. tamiae. the clinical spectrum of in ...200818592096
detrimental effects of bartonella henselae are counteracted by l-arginine and nitric oxide in human endothelial progenitor cells.the recruitment of circulating endothelial progenitor cells (epcs) might have a beneficial effect on the clinical course of several diseases. endothelial damage and detachment of endothelial cells are known to occur in infection, tissue ischemia, and sepsis. these detrimental effects in epcs are unknown. here we elucidated whether human epcs internalize bartonella henselae constituting a circulating niche of the pathogen. b. henselae invades epcs as shown by gentamicin protection assays and tran ...200818595894
transmission of bartonella henselae by ixodes ricinus.bartonella spp. are facultative intracellular bacteria associated with several emerging diseases in humans and animals. b. henselae causes cat-scratch disease and is increasingly associated with several other syndromes, particularly ocular infections and endocarditis. cats are the main reservoir for b. henselae and the bacteria are transmitted to cats by cat fleas. however, new potential vectors are suspected of transmitting b. henselae, in particular, ixodes ricinus, the most abundant ixodid ti ...200818598628
bartonella quintana and coxiella burnetii as causes of endocarditis, india. 200818598654
hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases.the incidence of hepatic granulomas is reported in 2-15% of liver biopsies. this study was carried out to evaluate the incidence and aetiology of hepatic granulomas in a german institute of pathology with specialization in liver diseases.200818312287
detection of two bartonella tamiae-like sequences in amblyomma americanum (acari: ixodidae) using 16s-23s intergenic spacer region-specific primers.four hundred and sixty-six questing amblyomma americanum (l.) (acari: ixodidae) from carolina county, va, and 98 questing a. americanum from chatham county, nc, were screened by polymerase chain reaction (pcr) for the bartonella 16s-23s intergenic spacer region. two amplicons, approximately 270-280 bp, were detected in two ticks from virginia. based upon pcr and sequencing, an adult male and adult female tick harbored dna sequences closely related to bartonella tamiae (dq395180). bartonella dna ...200818283962
infectious diseases of dogs and cats on isabela island, galapagos.vaccination and importation of dogs and cats are prohibited in the galapagos, resulting in a uniquely isolated population. the purpose of this study was to determine the prevalence of infectious diseases of dogs and cats that impact their health, could spill over to native wildlife, or sentinel diseases of concern to humans.200818289290
bartonella dna in the blood and lymph nodes of golden retrievers with lymphoma and in healthy controls.although lymphoma is the most common neoplastic process reported in dogs, its precise etiology is unknown. golden retrievers are more likely to develop lymphoma, suggesting a breed predisposition; however, other factors, including environment, immunity, and infection, are likely contributors to oncogenesis.200818289294
heterogeneity of susceptibility to fluoroquinolones in bartonella isolates from australia reveals a natural mutation in gyra.bartonella sp. are intracellular bacteria associated with an increasing number of clinical manifestations but with few published data on in vitro susceptibility testing of antibiotics. our objective was to evaluate in vitro antibiotic susceptibilities of 20 new bartonella isolates from animals in australia.200818334491
[stellar neuroretinitis and bartonella henselae infection. a case report without exposure to cats]. 200818187281
molecular characterization of bartonella vinsonii subsp. berkhoffii genotype iii.the molecular characterization of a bartonella vinsonii subsp. berkhoffii genotype iii strain (ncsu strain 06-co1) isolated from the blood of a military working dog diagnosed with endocarditis is reported in this study. several genes were amplified and sequenced for comparative sequence similarity with other strains.200818367567
[a high prevalence of antibodies against bartonella and babesia microti has been found in villages and urban populations in cordoba, colombia].establishing seroprevalence against bartonella and babesia microti in arural population exposed and/or non-exposed to domestic animals in cordoba,colombia.200818368229
temporal and spatial patterns of bartonella infection in black-tailed prairie dogs (cynomys ludovicianus).we describe the temporal dynamics and spatial distribution of bartonella in black-tailed prairie dogs (cynomys ludovicianus) based on a longitudinal study conducted in 20 black-tailed prairie dog (btpd) colonies in boulder county, co from 2003 to 2005. bartonella infection was widely distributed in all colonies with an overall prevalence of 23.1%, but varied by colony from 4.8% to 42.5% and by year from 9.1 to 39.0%, with a marked increase in bartonella activity in 2005. levels of bacteremia var ...200818176820
bartonella quintana and bartonella pediococcus infection after aortic valve replacement.bartonella quintana and bartonella pediococcus infections are very rare causes of endocarditis. urban trench fever with relapsing febrile illness, headache, leg pain, and endocarditis has now begun to be a more important cause of disease in socially disadvantaged persons. the diagnosis is difficult because the growth of b. quintana in blood culture takes 20-40 days. b. pediococcus may be an opportunistic pathogen in severely compromised hosts, although it has been described as a harmless bacteri ...200818430664
beyond cat scratch disease: widening spectrum of bartonella henselae infection.bartonella henselae was discovered a quarter of a century ago as the causative agent of cat scratch disease, a clinical entity described in the literature for more than half a century. as diagnostic techniques improve, our knowledge of the spectrum of clinical disease resulting from infection with bartonella is expanding. this review summarizes current knowledge regarding the microbiology, clinical manifestations, diagnostic techniques, and treatment of b. henselae infection.200818443019
a sacb mutagenesis strategy reveals that the bartonella quintana variably expressed outer membrane proteins are required for bloodstream infection of the host.bartonella bacteria adhere to erythrocytes and persistently infect the mammalian bloodstream. we previously identified four highly conserved bartonella quintana adhesin genes that undergo phase variation during prolonged bloodstream infection. the variably expressed outer membrane proteins (vomp) encoded by these genes are members of the trimeric autotransporter adhesin family. each b. quintana vomp appears to contribute a different adhesion phenotype, likely mediated by the major variable regio ...200818070893
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