Publications

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in vitro studies of semisynthetic alpha-(substituted-ureido) penicillins.the activity of three alpha-(substituted-ureido) penicillins was evaluated in vitro against 599 clinical isolates of gram-negative bacilli, by use of the broth-dilution technique. at a concentration of 12.5 mug or less/ml, bl-p1597 inhibited 90% of isolates of pseudomonas sp., 56% of enterobacter sp., 67% of indole-positive proteus spp., 72% of escherichia coli, and 85% of proteus mirabilis. bl-p1654 had similar activity, whereas bl-p1532 was much less active. at a concentration of 25 mug or les ...19714930281
bactericidal activity of bovine serums against coliform organisms isolated from milk of mastitic udders, udder skin, and environment. 19714930846
[changes of intestinal aerobic microbial flora in children with enterocolitis during hospitalization]. 19714931094
bile acid inhibition of the intestinal microflora--a function for simple bile acids? 19714935211
in vivo antibacterial activity of diaveridine-sulfonamide combinations. 19714935215
respiratory pathogens in monkeys.respiratory disease in a dynamic colony of nonhuman primates during a 4-year period was due primarily to infections caused by klebsiella pneumoniae, diplococcus pneumoniae, bordetella bronchiseptica, pasteurella multocida, and haemophilus influenzae. the principal secondary invaders were escherichia coli, staphylococcus aureus, and streptococci. a high fatality rate was associated with infections caused by each of the primary pathogens, and females appeared to be more susceptible than males. inc ...197116557951
cephalexin: absorption and excretion as related to renal function and hemodialysis.cephalexin is a new semisynthetic cephalosporin c derivative, which is well absorbed from the gastrointestinal tract and excreted in high concentration in the urine. even in patients with impaired renal function, the concentrations of cephalexin present in the urine are adequate for the treatment of most urinary tract infections produced by escherichia coli, klebsiella, and proteus mirabilis. in anephric patients, single doses of 250 or 500 mg of cephalexin resulted in high, prolonged serum conc ...197116558013
serum bacteriostasis of staphylococcus aureus.serum bacteriostasis of staphylococcus aureus was characterized quantitatively and quantitatively. bacteriostasis was proportional to the concentration of serum. reproducibility was good; freezing and thawing did not materially affect the end point. four of six different strains, including the propagating s. aureus strain for phage 73 which does not produce coagulase, were susceptible to serum bacteriostasis in similar titers; two were not susceptible at all. all six strains were effective inhib ...197116558034
comparative study of the metabolic and bactericidal characteristics of severely glucose-6-phosphate dehydrogenase-deficient polymorphonuclear leukocytes and leukocytes from children with chronic granulomatous disease. 19724403896
the pattern of bacterial infection in bronchial diseases in australia: a serological and bacteriological survey. 19724404399
additional immunochemical relationships of capsular polysaccharides of klebsiella and pneumococci. 19724404452
[present status of bacterial resistance to antibiotics and chemotherapeutic drugs and a tendency towards the development of resistance]. 19724404874
[pharyngeal microbial flora in newborn infants in an obstetrical clinic]. 19724405214
interpretation of tracheal cultures in patients with intubation and mechanical ventilation. 19724405569
acute obstructive laryngotracheobronchitis--report of six cases. 19724403234
cycloaddition of acetylenes to 7-acylamino-3-azidomethyl-3-cephem-4-carboxylic acids. 19724403250
the bacterial etiology and antibiotic management of septic arthritis in infants and children. 19724403468
a klebsiela outbreak in a pediatric nursery: emergency action and preventive surveillance. 19724483218
klebsiella meningitis--report of nine cases. 19724486486
hospital-acquired klebsiella bacteremia. 19724486502
perspective. hospital-acquired infections: the problems of methicillin-resistant staphylococcus aureus and infections with klebsiella pneumoniae. 19724486504
bacterial colonization profile with tracheal intubation and mechanical ventilation. 19724402112
changing patterns of susceptibility of common bacterial pathogens to antimicrobial agents. 19724402139
amoxycillin: a new semi-synthetic penicillin.amoxycillin (alpha-amino-p-hydroxybenzylpenicillin) is a new semi-synthetic penicillin with a broad spectrum of antibacterial activity similar to that of ampicillin. penicillin-sensitive strains of staphylococci, streptococci, and pneumococci were sensitive to concentrations of 0.1 mug or less of amoxycillin/ml. strains of haemophilus influenzae were inhibited by a level of 0.5 mug/ml, and most strains of escherichia coli, proteus mirabilis, shigella sonnei, salmonella species, and streptococcus ...19724402672
relation between cation and lipid content of cell walls of pseudomonas aeruginosa, proteus vulgaris and klebsiella aerogenes and their sensitivity to polymyxin b and other antibacterial agents. 19724402781
intravenously administered doxycycline in urological and surgical infections. 19724402952
clinical and bacteriological evaluation of intravenous doxycycline in severe hospital infections. 19724401232
antibacterial activity of 6-(5-membered heteroarylacetamido)penicillanic acids. 19724400584
[incompatibility groups of plasmids confering resistance to gentamicin]. 19724354669
the effect of nitrofurantoin on the morphology of gram-negative bacilli. 19724550229
incidence of antibiotic resistance and r factors among gram-negative bacteria isolated from the neonatal intestine. 19724550448
nifuratel in chronic urinary infections. 19724550718
an r factor defects to our side. 19724550892
[waterhouse-friderichsen syndrome in a 7-day-old newborn infant due to klebsiella pneumoniae]. 19724550933
otitis media in the first six weeks of life: diagnosis, bacteriology, and management. 19724551016
[improved bacteriological urine diagnostics]. 19724551392
[changes in the antibiotic resistance of pathogenic bacteria during 1967-1970]. 19724551651
antimicrobial sensitivity patterns as a guide to the domiciliary treatment of urinary tract infections. 19724551815
rhinoscleroma, an electron-microscopy study. 19724552099
problems of the epidemiology of scleroma. 2. some aspects of the problem of endemic focus formation. 19724552101
bacteriuria in a scottish island community. a comparison of chemical and cultural tests for bacteriuria applied in remote surroundings.four hundred and thirty-eight overtly healthy adults on tiree were screened for bacteriuria by dip-inoculum culture and a tetrazolium reductase test.dip-inoculum culture affords a simple and effective means of providing a service in quantitative urine bacteriology for communities remote from a laboratory.the pattern of bacteriuria on tiree is much the same as in other communities surveyed. criteria are discussed for assessing the sensitivity of the tetrazolium test in terms of quantitative urine ...19724552256
the action of trimethoprim-sulphamethoxazole against urinary pathogens. 19724552261
[infectious hepatobiliary diseases]. 19724552440
trimethoprim resistance determined by r factors.r factors conferring a high level of resistance to trimethoprim have been identified in one strain of escherichia coli and one of klebsiella aerogenes, both isolated from infected urines.19724552466
enterobacteriaceae isolated from cowbirds (molothrus ater) and other species of wild birds in michigan. 19724552674
epidemiological differentiation of serratia marcescens: typing by bacteriocin sensitivity.strains of serratia marcescens were compared and differentiated by a new method. bacteriocin lysates were prepared from mitomycin-induced s. marcescens and added to lawns of test strains. from 100 bacteriocin producers, 12 were chosen with the aid of computer analysis as the most useful in differentiation. uniform drops of the 12 standard bacteriocins were added simultaneously with a bacteriocin-bacteriophage dropper to each strain to be typed. all 93 strains of s. marcescens tested were typable ...19724552885
[complications and their treatment in children with hydrocephalus and spitz-holter valve]. 19724553029
blood cultures showing aberrant forms of bacteria. 19724553131
comparison of the substrate specificities of the -lactamases from klebsiella aerogenes 1082e and enterobacter cloacae p99.a potent beta-lactamase (ec 3.5.2.6) produced by a strain of klebsiella aerogenes (k. pneumoniae), 1082e, isolated from a hospital patient, has been examined. its properties were different from those of most gram-negative beta-lactamases previously reported. the enzyme has been partly purified, and its activity against a range of substrates has been compared with that of the enzyme from enterobacter cloacae (aerobacter cloacae) p99. the k. aerogenes enzyme, although predominantly a penicillinase ...19724553144
ornithine analogs as potential ornithine decarboxylase inhibitors 1. n-substituted ornithine derivatives. 19724553328
corrected identification of a test organism (atcc 4352) previously thought to be escherichia coli.a gram-negative test organism (atcc 4352) previously identified as escherichia coli was found to be klebsiella pneumoniae.19724553806
[gram-negative bacilli isolated in a hospital department. their sensitivity to gentamycin]. 19724553864
studies on the frequency of occurrence of r factor in klebsiella bacilli. 19724554267
in vitro effect of cystographic contrast media on urinary tract pathogens. 19724554443
isolation of a polyvalent bacteriophage for escherichia coli, klebsiella pneumoniae, and aerobacter aerogenes.a lytic bacteriophage isolated from sewage was found to attack strains of aerobacter aerogenes, escherichia coli, and klebsiella pneumoniae, but not members of the genera salmonella, proteus, and serratia. the phage, designated phimp, contained deoxyribonucleic acid with a 50% guanine plus cytosine ratio and a molecular weight of 23.1 x 10(6) daltons. single-step growth experiments of phimp plated at 37 c on a. aerogenes a2 gave a mean latent period of 20 min, an average burst size of 103 plaque ...19724554466
polyguanylic acid-inhibited ribonuclease of klebsiella. ii. studies with synthetic polyribonucleotides. 19724554642
clinico-bacteriological study of urinary tract infection. 19724554678
[bacterial replacements in urinary tract infections and clinical observations]. 19724554980
synergistic necrotizing cellulitis. 19724555030
sepsis and gastrointestinal bleeding. 19724555031
early recognition of neonatal sepsis. the value of bacteriologic studies of gastric aspirate and external ear canal material. 19724555038
data processing in hospital bacteriology: experience of 18 months' trial.the nature of bacteriological investigations creates data processing problems. non-numerical results must be coded. this may be done retrospectively or at the bench, the former method involving extra work and staff, the latter implying simple codes, stringent checking, a nearby computer, and decoding programs. the use of a shared computer for producing daily reports diminishes departmental autonomy. benefits occur in more readily available records and statistics, quality control, epidemiology, a ...19724555043
experiences with the analytab system for the identification of enterobacteriaceae. 19724555068
the antibacterial action of spices and its nutritional implications. 19724555287
in vitro susceptibility of gram-negative bacilli to carbenicillin. 19724555345
[diagnosis and therapy of septicemia]. 19724555374
correlation between hydrolysis of the -lactam bond of the cephalosporin nucleus and expulsion of the 3-substituent.the hydrolysis of two cephalosporins by three different beta-lactamases has been studied. each enzyme caused a decrease in ultraviolet absorption, a loss of biological activity, and the release of the leaving group from the 3-position. the changes occurred at the same rate and to the same extent with each enzyme, and it is inferred that the loss of the leaving group is a consequence of, and not a prerequisite for, hydrolysis of the beta-lactam ring.19724555421
genetic transfer of nitrogen fixation from klebsiella pneumoniae to escherichia coli. 19724555442
chemical modification of erythromycin antibiotics. 4. structure-activity relationships of erythromycin esters. 19724555493
infections in cancer patients. results with gentamicin sulfate therapy. 19724555556
antimicrobial activity of 5-nitro-2-furaldehyde-n'-methyl-n-piperazinoacethydrazone, a new hydrosoluble nitrofurane derivative. i. in vivo antibacterial activity. 19724556173
[systemic infections in liver cirrhosis, with special reference to general peritonitis caused by gram-negative bacilli infection]. 19724556373
microbiology of nosocomial infections. 19724556415
generalized hamartomatosis. (copngenital generalized fibromatosis). 19724556766
[bacterial cultures in acute infections in children]. 19724557139
serum bactericidal activity in patients with upper and lower urinary tract infections. 19724557280
bacterial agglutination studies with secretory iga prepared from human gastrointestinal secretions and colostrum.the function of human purified colostral and gastrointestinal iga has been studied by its ability to agglutinate common gastrointestinal organisms. agglutinating activity was unaffected by trypsin or acid but it was abolished rapidly by pepsin. both colostral and gastrointestinal iga agglutinated a wide range of enteric organisms. variations in this activity occurred between different individuals, and between different gastrointestinal sites in the same individual. in preliminary studies, saliva ...19724557307
the diagnosis and management of bacterial prostatitis. 19724557440
the changing pattern of hospital-acquired infections: increase of infections by gram-negative bacteria. 19724557452
bacteremia after genitourinary tract manipulation: bacteriological aspects and evaluation of various blood culture systems.a total of 300 patients undergoing various types of urological procedures was studied for incidence of bacteremia. an osmotically stabilized anaerobic broth with sodium polyanethol sulfonate (liquoid) yielded more positive blood cultures than any other culture system and was also the best system by far for recovery of anaerobes. the membrane filter showed faster growth and, therefore, facilitated faster identification of the infecting organism. there was a 31% incidence of bacteremia in the pati ...19724557560
selective medium for hydrogen sulfide production by salmonellae.triple sugar iron agar does not reveal hydrogen sulfide production by all salmonella organisms nor does it permit clear-cut separation of those nonsalmonellae which produce h(2)s. numerous media with varied combinations of nutrients, inhibitors, selective agents, ph levels, and metal salts were tested for h(2)s production of cultures of salmonella, citrobacter, edwardsiella, arizona, proteus, providencia, klebsiella, and enterobacter. an agar medium has been devised which promotes growth and h(2 ...19724557561
[determination of the photoelectric work of emission of bacterial fractions]. 19724557568
[significance of suprapubic bladder puncture in bacteriological diagnostics. i. technic and bacterial spectrum]. 19724558290
[value of intestinal microflora for balanced human nutrition]. 19724558483
[coexistence of trichimonas vaginalis and gram-negative bacteria in the etiology of urinary tract infections in newborn infants]. 19724558485
[transferable resistance to gentamicin. ii. transmission and linkage of the resistance character]. 19724559312
bacterial colonization of the respiratory tract in hospitalized patients with malignant diseases. 19724560053
nosocomial infections due to kanamycin-resistant, (r)-factor carrying enteric organisms in an intensive care nursery. 19724560309
catalase test as an aid to the identification of enterobacteriaceae.although the catalase test has been used for many years for rapid differentiation of the genera of gram-positive organisms, little has been said about its use in the family enterobacteriaceae. it was further noted that a wide variety of methods exist for the execution of the catalase test, that there is no universally accepted strength specified for the hydrogen peroxide, and that no gradations for the vigor and speed of the reaction have been mentioned. under the conditions of the clinical labo ...19724560474
electron microscopic investigations of klebsiella rhinoscleromatis in culture. 19724560670
nalidixic acid by intravenous infusion. a report of 50 cases. 19724560832
bacterial flora in intraabdominal ileostomy reservoir. a study of 23 patients provided with "continent ileostomy". 19724561039
[chemotherapy of urinary tract infections in children and standards for evaluating its efficacy--with special reference to the therapeutic results of cephalexin suspensions]. 19724561052
antimicrobial agents from higher plants. i. introduction, rationale, and methodology. 19724561056
urinary tract infections in association with radium therapy for gynecological cancer. 19724561174
inhibition of the -lactamases of escherichia coli and klebsiella aerogenes by semi-synthetic penicillins.1. a new automated micro-iodometric method is described for screening compounds for inhibitory action against beta-lactamase enzymes. 2. over 1000 semi-synthetic penicillins were tested for inhibitory activity against the beta-lactamase of escherichia coli b11 and 18 showed a fractional inhibition similar to or higher than that of methicillin. 3. the best inhibitors were alkoxy- and halogen-substituted phenyl-, naphthyl- or quinolyl-penicillins. 2-isopropoxy-1-naphthylpenicillin (brl 1437) was c ...19724561388
[septicemia in acute leukemia]. 19724561738
experiences in the use of commercial antisera for the capsular typing of klebsiella species. 19724561950
trimethoprim resistance conferred by w plasmids in enterobacteriaceae. 19724562309
experimental studies for the evaluation of bactericidal plastic surgical sutures. 19724562337
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