Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| pathogenic mechanisms of helicobacter pylori. | there is general agreement that motility, urease activity, and association with gastric mucosal cells are important virulence factors of h. pylori. urease activity is perhaps the best characterized of these factors. presumably, urease activity creates a "cloud" of ammonia around the bacterium, thus neutralizing the lethal effects of gastric acid. motility allows the bacterium to penetrate the mucus layer and promotes specific association of the bacteria with epithelial cells, further allowing ev ... | 1993 | 8449569 |
| microbiology of helicobacter pylori. | the new genus name helicobacter was first published in october 1989. h. pylori is a unipolar, multiflagellate, gently spiral organism found on the human gastric mucosa, but in culture and under unfavorable conditions, coccoidal forms emerge, which may be indicative of a dormant state. the biology and metabolism of h. pylori, together with growth requirements and methods of detection in clinical specimens, are described in this article. enzymes, hemagglutinins, and antibiotic susceptibilities of ... | 1993 | 8449570 |
| helicobacter pylori-associated gastric pathology. | h. pylori is the most common cause of nonerosive nonspecific gastritis; however, its main importance has been as a marker in research studies of eradication in relation to duodenal ulcer relapse. in developed countries, the most common histologic pattern appears to be that of a mild superficial chronic active gastritis. when h. pylori is present in the antrum it is virtually always present in the body as well, although inflammation in body mucosa is usually milder than that in the antrum. the or ... | 1993 | 8449571 |
| epidemiology of helicobacter pylori infection. | recent studies have shown that seroprevalence curves of helicobacter pylori infection in fact reflected the rate of acquisition in childhood. although the reservoir is well known, the routes of infection are still poorly understood: are they oral-oral or fecal-oral? | 1993 | 8449572 |
| helicobacter pylori and gastric cancer. | gastric cancer remains among the leading types of cancer worldwide. there is now convincing evidence linking h. pylori to adenocarcinomas of the gastric antrum, body, and fundus. these tumors are rapidly decreasing in incidence in the united states, whereas cardia tumors, tumors unassociated with h. pylori infection, are on the increase. although criteria for causality have not been completely fulfilled for h. pylori and adenocarcinoma, there are plausible mechanisms by which chronic inflammatio ... | 1993 | 8449573 |
| dr. apley meets helicobacter pylori. | 1993 | 8450375 | |
| helicobacter pylori infection in children: potential clues to pathogenesis. | children (227) undergoing endoscopy for upper gastrointestinal symptoms were investigated for the presence of helicobacter pylori infection. the histological response to h. pylori infection and the presence of antral nodularity and peptic ulceration were noted. symptomatic adults (258) undergoing endoscopy were also investigated for the presence of nodularity. h. pylori infection was detected histologically in 32 of 227 (14.1%) children. of those children infected with h. pylori, half (50%) had ... | 1993 | 8450376 |
| helicobacter pylori-associated gastritis in kuwait: endoscopy-based study in symptomatic and asymptomatic children. | information is limited concerning the prevalence of helicobacter pylori infection in asymptomatic children. since january 1989, we have endoscoped 60 children for recurrent abdominal pain or for obtaining small-intestinal biopsy (their ages were a mean of 6.6 (range 9 months-13 years); there were 37 boys and 23 girls. antral biopsies were obtained from all subjects and these were studied for the presence of gastritis and stained for h. pylori using modified gram's stain. all biopsies were cultur ... | 1993 | 8450377 |
| pathogenesis and early lesions in extranodal lymphoma. | extranodal lymphomas that arise in tissues normally devoid of lymphoid tissue provide a unique opportunity for the study of the pathogenesis of lymphoma without the distraction of surrounding lymphoid tissue. this applies particularly to mucosa-associated lymphoid tissue (malt) b-cell lymphomas, so named because they recapitulate the structure of normal malt rather than that of lymph nodes. before these lymphomas develop, malt accumulates, usually in response to autoimmune injury associated with ... | 1993 | 8451763 |
| [occurrence of helicobacter pylori and gastritis among healthy persons without gastrointestinal symptoms]. | 1993 | 8451786 | |
| diagnosis of helicobacter pylori infection by means of a polymerase chain reaction assay for gastric juice aspirates. | a polymerase chain reaction (pcr) assay for helicobacter pylori was developed with use of primer sequences from the urea structural gene coding for the small subunit of urease. the pcr amplification was 100% specific for h. pylori in tests with 40 stock isolates of this species and with 30 control organisms, including two species of urease-producing helicobacter. thirty-four dyspeptic patients were evaluated by culture and histologic assessment of antral biopsy samples as well as by pcr of gastr ... | 1993 | 8452948 |
| [helicobacter pylori and the treatment of gastric ulcer. reflections and uncertainties]. | the authors examine the relationship between helicobacter pylori and gastric ulcer therapy, analyzing both the data suggesting that eradication of the organism renders the gastric mucosa less susceptible to development of gastric ulcer and the substantial body of evidence to the contrary. they review the results reported in clinical trials with colloidal bismuth subcitrate, antimicrobial agents (furazolidone), and combinations of antiulcer and antimicrobial agents (h2-antagonist + cefixime, h2-a ... | 1993 | 8452981 |
| effects of atpase inhibitors on the response of hela cells to helicobacter pylori vacuolating toxin. | approximately 50% of helicobacter pylori strains produce a toxin in vitro that induces vacuolation of eukaryotic cells. to determine whether ion transport pathways are important in the formation of toxin-induced vacuoles, hela cells were incubated with h. pylori toxin in the presence of nine different inhibitors of ion-transporting atpases. oligomycin, an inhibitor of predominantly f1f0-type atpases, had no effect on toxin activity. inhibitors of predominantly v-type atpases, exemplified by bafi ... | 1993 | 8454346 |
| helicobacter pylori and gastric carcinoma. | 1993 | 8454883 | |
| helicobacter (campylobacter) fennelliae-like organisms as an important but occult cause of bacteraemia in a patient with aids. | we describe the isolation and identification of a helicobacter (campylobacter)-like organism obtained from the blood of a 32-year-old homosexual man with a 10 months' history of aids and progressive mucocutaneous kaposi sarcoma. fever and bacteremia persisted despite sequential administration of ciprofloxacin and trimethoprim-sulfamethoxazole, antibiotics reported to be active against this organism in vitro. facultative organisms like campylobacter fennelliae and campylobacter cinaedi which are ... | 1993 | 8454896 |
| can severity of symptoms be used as an outcome measure in trials of non-ulcer dyspepsia and helicobacter pylori associated gastritis? | most trials of non-ulcer dyspepsia (nud) and helicobacter pylori associated gastritis (hpag) have not used validated methods of measuring symptoms. three attributes are necessary for use of symptom severity scoring systems as outcome measures in clinical trials: reproducibility, responsiveness to change and validity compared to corroborating measures. the objective of this study was to establish that selected gastrointestinal symptoms recorded as a series of 5-point likert scales meet the 3 crit ... | 1993 | 8455052 |
| opsonic requirements of helicobacter pylori. | the opsonic requirements of helicobacter pylori were investigated in a series of experiments with human polymorphonuclear leucocytes (pmnl). pre-incubation of h. pylori with pooled normal human serum (nhs) in concentrations of 5-20% significantly increased the uptake of radiolabelled bacteria by pmnl. treatment of the bacteria with nhs 30% caused the release of radiolabel and this effect was abolished by heating serum to 56 degrees c, suggesting that h. pylori is serum-sensitive and that complem ... | 1993 | 8455190 |
| survival and ultrastructural changes of helicobacter pylori after phagocytosis by human polymorphonuclear leukocytes and monocytes. | few studies have been carried out on the phagocytosis and killing of helicobacter pylori by both polymorphonuclear leukocytes (pmns) and monocytes. in this study, h. pylori was incubated for up to 60 min either alone or with phagocytes in the presence or absence of human serum. both non-immune serum and immune serum were used. reduction in the number of h. pylori, which corresponds to the killing of h. pylori, was analysed by a colony count and ultrastructural changes were studied by electron mi ... | 1993 | 8457327 |
| unusual infections in humans. | nine cases of unusual infections in humans are presented. in each case, we present the clinical history, histopathologic changes (if indicated), morphologic features of the causative organism, diagnosis, discussion, differential diagnosis, therapy, and current literature. all of the cases are illustrated with pertinent photographs. the nine cases are as follows: (i) acanthocephaliasis, the first acquired human infection by moniliformis moniliformis in the united states; (ii) dipylidiasis, an unc ... | 1993 | 8457979 |
| septicemia and meningitis caused by helicobacter cinaedi in a neonate. | helicobacter cinaedi has been most frequently isolated from rectal swabs of homosexual men with proctocolitis. the microorganism is a normal intestinal inhabitant of hamsters. we report a case of septicemia and meningitis by h. cinaedi in a neonate whose mother cared for pet hamsters during the first two trimesters of her pregnancy. the isolate was detected after 3 days of incubation in a bact/alert pediatric blood culture vial and an enrichment broth culture of the cerebrospinal fluid. h. cinae ... | 1993 | 8458951 |
| three supplementary diagnostic tests for campylobacter species and related organisms. | we analyzed 307 recent clinical isolates and reference strains of campylobacter spp., helicobacter spp., and arcobacter spp. for arylsulfatase and pyrazinamidase activities and susceptibility to polymyxin b. all isolates studied were identified by dna dot hybridization prior to testing. campylobacter concisus, c. sputorum, and helicobacter fennelliae were positive for arylsulfatase. c. jejuni, c. coli, c. lari, c. upsaliensis, and c. concisus were positive for pyrazinamidase. only helicobacter s ... | 1993 | 8458969 |
| [follow-up of the quantitative serological response to the treatment of helicobacter pylori infection in children]. | the aim of the present study was to know the usefulness of a enzyme immunoanalysis (eia) technique for the monitorization of the serologic to treatment of infection by helicobacter pylori in spanish children. | 1993 | 8461370 |
| [evaluation of the cut-off point in the serological diagnosis of helicobacter pylori infection in children using an enzyme immunoassay technique]. | 1993 | 8461377 | |
| helicobacter pylori may be transmitted through gastrofiberscope even after manual hyamine washing. | endoscopy is an effective diagnostic technique for gastric cancer, which is believed to be associated with helicobacter pylori. manual hyamine washing is a widely used fiberscope cleaning method. urease b gene of helicobacter pylori was detected in 50% of the wash-out samples from the biopsy-suction channel of a fiberscope after manual hyamine washing by nested polymerase chain reaction, and bacterial culture revealed viable helicobacter pylori in 19%. however, helicobacter pylori was not detect ... | 1993 | 8463128 |
| detection of helicobacter pylori in dental plaque by reverse transcription-polymerase chain reaction. | to investigate whether the oral cavity is a potential reservoir and possible sanctuary for helicobacter pylori, supragingival and subgingival plaques were analyzed by a helicobacter genus-specific reverse transcriptase-polymerase chain reaction based on the sequence data of h. pylori 16s rrna. the amplified 500-bp dna fragment was identified by ethidium bromide staining after agarose gel electrophoresis and by southern hybridization. twenty-five dyspeptic patients were studied. histologic examin ... | 1993 | 8463387 |
| bile reflux and intestinal metaplasia in gastric mucosa. | to determine associations between enterogastric bile reflux and gastric mucosal pathology. | 1993 | 8463417 |
| mucin exocytosis: a major target for helicobacter pylori. | to determine whether helicobacter pylori impairs the secretory function of mucous cells. | 1993 | 8463418 |
| [an efficient method for quantification of helicobacter pylori in biopsy specimen using pcr]. | a procedure for the detection and quantification of helicobacter pylori in gastrointestinal tissue biopsy specimens by polymerase chain reaction (pcr) is presented. this method provides an accurate quantitative and sensitive measurement of the amount of h. pylori in the gastrointestinal tract without cultivation of this microorganism. we have used 30 cycles of pcr in the presence of 3.5mm mg++ and demonstrated that the dna content of one h. pylori cell is 0.0076pg. using this approach, we analyz ... | 1993 | 8464178 |
| [peptic activity of gastric juice in chronic gastritis. morpho-functional aspects]. | the aim of this study has been to evaluate peptic activity in gastric juice and gastric peptic cell mass in chronic gastritis. as regard peptic activity, there is a close correlation between it and the peptic gastric cell mass considered globally and expressed as peptic gastric index (pgi), resulting from the individual average between fundic peptic index (chief cells + fundic muco-peptic cells) and antral peptic index (antral muco-peptic cells), both obtained by multiplying the number of peptic ... | 1993 | 8464563 |
| prevalence of antibody to helicobacter pylori in children in northern nigeria. | helicobacter pylori infection is common in northern nigeria, but the age of acquisition is unknown. in a prospective study, immunoglobulin g antibodies to h. pylori were measured in 143 children under the age of 20 years. ninety-one percent of 43 randomly chosen subjects over 10 years had antibodies to h. pylori. a further 100 children under 10 years presenting to the university of maiduguri teaching hospital were also tested. sixty-nine percent had antibodies, including 58% of those aged under ... | 1993 | 8465385 |
| the 13c-urea breath test--detection of helicobacter pylori infection in patients with partial gastrectomy. | the 13c-urea breath test (13c-ubt) for diagnosis of helicobacter pylori (hp) infection was evaluated in 41 patients after partial gastrectomy and was used for determination of the hp-prevalence after two different procedures of reconstruction of the gastrointestinal tract, i.e. billroth's ii operation and roux-en-y anastomosis. breath samples were taken at various time points within 30 minutes after a motility inhibiting liquid test meal with citric acid followed by 75 mg of 13c-urea. the 13co2/ ... | 1993 | 8465552 |
| helicobacter pylori infection. rapid diagnosis with brush cytology. | the validity of brush cytology of the gastric mucosa with diff-quik rapid staining was studied in 69 samples, and its effectiveness was compared with two other techniques (culture and urease test). brush cytology is the method of choice for detecting helicobacter pylori since it is rapid, easy to perform and has good sensitivity and specificity. | 1993 | 8465638 |
| serum anti-helicobacter pylori igg antibodies and pepsinogens a and c as serological markers of chronic atrophic gastritis. | this study was designed to test the sensitivity and specificity of serum anti-helicobacter pylori igg antibodies and the ratio of serum pepsinogen a to pepsinogen c (pga:pgc) in detecting chronic atrophic gastritis (cag) and intestinal metaplasia. parallel gastric biopsies and a serum sample were collected from a series of 87 patients aged 20-69 years attending a routine upper endoscopy clinic. the seroprevalence (> 10 micrograms igg/ml) of anti-h. pylori antibodies was 42.7%, and of a low pga:p ... | 1993 | 8467246 |
| a computer program in quickbasic for the selection of tests for the identification of helicobacter pylori. | reliable microbiological tests are needed for the identification of bacteria. a program has been written in quickbasic to identify such tests by using a formula that is based on gyllenberg's sum of c(i) and gyllenberg's rank r(i). a total of 139 papers on a newly isolated bacterium, helicobacter pylori, was used as data source for the coding of test results into an input file. the program outputs a list that aids in the determination of suitable tests for the identification of h. pylori. these t ... | 1993 | 8467636 |
| helicobacter pylori and peptic ulcer disease. | 1993 | 8468160 | |
| 14c-urea breath test--a simple, noninvasive method for the detection of helicobacter pylori infection. | 1993 | 8468178 | |
| [differences in susceptibility of helicobacter pylori to macrolide and other antibiotics in tests using blood agar and albumin agar]. | minimum inhibitory concentrations (mics) of penicillin g, cefazolin, tetracycline, chloramphenicol, four aminoglycosides, and seven macrolides against helicobacter pylori strains were determined on brucella agar supplemented with bovine serum albumin fraction v (albumin agar) and compared with those on blood agar. mics of the macrolides against h. pylori determined on albumin agar were markedly lower than those found with blood agar. the susceptibilities of 26 h. pylori strains to the macrolides ... | 1993 | 8468498 |
| ulcers as an infectious disease. | 1993 | 8469968 | |
| ph and hp--gastric acid secretion and helicobacter pylori: implications for ulcer healing and eradication of the organism. | 1993 | 8470623 | |
| omeprazole plus amoxicillin: efficacy of various treatment regimens to eradicate helicobacter pylori. | in five subsequent open clinical studies, 180 patients with helicobacter pylori (hp)-associated ulcer disease (n = 163) or severe functional dyspepsia (n = 17) requiring therapy were treated with either 40 mg omeprazole plus 4 x 500 mg amoxicillin suspension for 1 wk (group i, n = 35), 2 x 40 mg omeprazole plus 4 x 500 mg amoxicillin for 1 wk (group ii, n = 50), 2 x 20 mg omeprazole plus 4 x 500 mg amoxicillin for 2 wk (group iii, n = 62), 2 x 20 mg omeprazole (day 1-14) and 4 x 500 mg amoxicill ... | 1993 | 8470626 |
| patient factors affecting helicobacter pylori eradication with triple therapy. | duodenal ulcer recurrence and gastritis are reduced with successful helicobacter pylori treatment. to identify the patient factor influencing h. pylori eradication, we prospectively evaluated 96 consecutive patients undergoing a single 2-wk course of bismuth, tetracycline, and metronidazole therapy. at the time of initial esophagogastroduodenoscopy with biopsies, each patient had a profile obtained which included demographic information, gastrointestinal pathology, and h. pylori status of the sp ... | 1993 | 8470629 |
| esophagitis and helicobacter pylori in children: incidence and therapeutic implications. | the relationship between gastric helicobacter pylori colonization and esophagitis was determined in 457 children undergoing endoscopic evaluation of abdominal pain and/or vomiting. in all patients, biopsies of the esophagus were examined histologically, and two antral biopsies were analyzed for the presence of h. pylori, using standard microbiological and histochemical techniques. the incidence of biopsy-proven esophagitis was similar in h. pylori-positive (15/56 patients) and -negative (94/401; ... | 1993 | 8470630 |
| helicobacter pylori does not increase gastrin in chronic gastritis. | 1993 | 8470651 | |
| gastric cancer and helicobacter pylori infection. | gastric adenocarcinoma can be divided into two histopathological types: intestinal and diffuse. in addition to the role of environmental factors, an association between gastric cancer and helicobacter pylori has been suggested. a retrospective study was therefore carried out among 46 patients who had gastric cancer. as a control group, 40 patients with non-malignant disorders were selected (11 patients with peptic ulcer, 12 with chronic superficial gastritis, 17 with chronic atrophic gastritis). ... | 1993 | 8472158 |
| helicobacter pylori: 10th anniversary of its culture in april 1982. | 1993 | 8472974 | |
| effect of ranitidine bismuth citrate on postprandial plasma gastrin and pepsinogens. | ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. twenty four men with duodenal ulcers were studied before and on the 8th day of dosing with either ranitidine bismuth citrate 800 mg twice daily or ranitidine 300 mg twice daily (double blind, randomised, parallel groups). fasting and postprandia ... | 1993 | 8472980 |
| secretor status and helicobacter pylori infection are independent risk factors for gastroduodenal disease. | the hypothesis that non-secretors of abo blood group antigens, a group shown to be more susceptible to certain bacterial infections, may be at greater risk of gastroduodenal disease because of increased susceptibility to helicobacter pylori infection was investigated. of 101 patients with symptoms of dyspepsia who were undergoing endoscopy, 32% were non-secretors (determined from lewis blood group phenotype), 36% had endoscopically visible gastroduodenal disease (antral gastritis, gastric ulcer, ... | 1993 | 8472982 |
| prevalence of metronidazole-resistant helicobacter pylori in dyspeptic patients. | susceptibility to metronidazole of 213 clinical strains of h. pylori from dyspeptic patients was determined by a plate dilution method. seventy two (33.8%) of the strains were resistant to metronidazole (mic > 8 mg/l), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primary (pretreatment) resistance rate of 27.5% (52/189). the resistance rate was higher in women than in men, especially aged 50 to 59 years old (43.6% vs 23.3%, p < 0.001). the resistan ... | 1993 | 8473130 |
| characterisation of a helicobacter pylori phage (hp1). | the infection of two helicobacter pylori strains with a phage-containing supernate of the lysogenic h. pylori strain immi 290/89 resulted in a lytic cycle and propagation of phage hp1. in negatively-stained preparations, the empty phage heads measured 55-60 nm in diameter and mature heads measured 50 nm. the flexible, striated phage tail was c. 170 nm in length and 9.5 nm in diameter. the phage showed a mean density of 1.40 g/cm3 in sucrose-density gradients and contained double-stranded dna c. ... | 1993 | 8474115 |
| genetic transformation in helicobacter pylori. | genetic transformation in helicobacter pylori was investigated by using its chromosomal and plasmid dnas. six out of the eight strains exhibited the natural competence for incorporation of h. pylori chromosomal dna, and all the strains incorporated the donor dna efficiently by washing and concentrating the cells with a glycerol solution. the much higher frequency of transformation was obtained in each strain by means of electroporation. electroporation experiments were also conducted by use of t ... | 1993 | 8474363 |
| ulcer risk factors: interactions between helicobacter pylori infection, nonsteroidal use, and age. | to evaluate the influence of helicobacter pylori, nonsteroidal anti-inflammatory drug (nsaid) use, tobacco and alcohol use, age, gender, ethnic group, and the indication for endoscopy on the frequency of gastric and duodenal ulcers in patients referred for upper endoscopy. | 1993 | 8475935 |
| surgery for acid suppression in the 1990s. | 1993 | 8477110 | |
| acid suppression and the gastric flora. | 1993 | 8477111 | |
| pathogenicity of helicobacter pylori: a perspective. | 1993 | 8478048 | |
| cloning and expression of a high-molecular-mass major antigen of helicobacter pylori: evidence of linkage to cytotoxin production. | a high-molecular-mass (120- to 128-kda) helicobacter pylori antigen has been associated with peptic ulcer disease. we created a bank of 40,000 random chromosomal fragments of h. pylori 84-183 by using lambda zapii. screening of this bank in escherichia coli xl1-blue with absorbed serum from an h. pylori-infected person permitted the isolation and purification of a clone with a 3.5-kb insert. subcloning of this insert (pmc3) permitted the expression of a recombinant h. pylori protein that had a m ... | 1993 | 8478069 |
| in-vitro activity of dirithromycin in comparison with other new and established macrolides. | improvements with regard to the in-vitro activity of new macrolides are marginal and apply mainly to haemophilus spp., moraxella catarrhalis and neisseria gonorrhoeae (e.g. azithromycin is two to eight times more active than erythromycin) and to non-enterococcal streptococci (e.g. clarithromycin is two to four times more active than erythromycin). the increase in activity against staphylococci is even less striking, being restricted to a few species and limited to clarithromycin (twice as active ... | 1993 | 8478311 |
| radiation dose estimates for the carbon-14-labeled urea breath test. | the use of the 14c-urea breath test for diagnosis of helicobacter pylori infection in gastric mucosa has gained widespread acceptance and utilization. in order to obtain regulatory approval for this procedure, new dose estimates were required. previous radiation dose equivalent estimates for males only were based upon data published in 1975 for bicarbonate metabolism. since that time, calculational techniques for dose estimation have been significantly improved and the organ masses of reference ... | 1993 | 8478718 |
| helicobacter pylori prevalence in acquired immunodeficiency syndrome. | helicobacter pylori is consistently reported with high prevalence in hiv-negative patients with chronic gastritis and active ulcer disease. this study is an evaluation of the prevalence of h. pylori in aids patients, and the association with chronic gastritis, erosions, and ulcer disease. seventy-three aids patients referred for the evaluation of gastrointestinal symptoms underwent upper endoscopy and antral gastric biopsy. histologic gastritis was diagnosed and degree of activity graded on hema ... | 1993 | 8480733 |
| successful helicobacter pylori eradication: a systemic effect of antibiotics? | 1993 | 8480762 | |
| helicobacter pylori. | 1993 | 8481148 | |
| local cellular and immune response by antral mucosa in patients undergoing treatment for eradication of helicobacter pylori. | thirty-six patients with nonhealing or recurrent duodenal ulcers (du) were treated with omeprazole; 20 mg/day for one month followed by triple therapies (metronidazole, 400 mg three times a day, tetracycline, 500 mg four times a day with either colloidal bismuth, 120 mg four times a day or sucralfate 1 g four times a day. at least two gastric mucosal samples were collected from the antral portion of the stomach and from the duodenum before and immediately after omeprazole therapy and four weeks ... | 1993 | 8482195 |
| ethnic differences in helicobacter pylori infection. | 1993 | 8482295 | |
| menetrier's disease: a form of hypertrophic gastropathy or gastritis? | menetrier's disease is characterized by giant gastric folds and foveolar hyperplasia. the extent of mucosal inflammation and glandular atrophy, however, is controversial. the aim of this study was to test the hypothesis that patients previously diagnosed with menetrier's disease actually represent at least two diseases: (1) hypertrophic lymphocytic gastritis (hlg) and (2) massive foveolar hyperplasia and minimal inflammation (mfh). | 1993 | 8482445 |
| long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. | the effects of chronic drug-induced hypergastrinemia on the exocrine and endocrine stomach are still incompletely understood. chronic hypergastrinemia in rats and humans is associated with gastric argyrophil cell hyperplasia. | 1993 | 8482449 |
| prolonged achlorhydria and gastric neoplasia: is there a causal relationship? | 1993 | 8482469 | |
| two-week eradication regimen for metronidazole-resistant helicobacter pylori. | at present there is no generally accepted treatment regimen for eradicating metronidazole-resistant helicobacter pylori. this study determines the eradication rate after treatment with 40 mg omeprazole o.m. and 500 mg amoxycillin q.d.s. for 14 days, with 120 mg tripotassium dicitrato bismuthate q.d.s. for the first week (days 1-7) and 750 mg ciprofloxacin b.d. for the second week (days 8-14). thirty patients (16 male, mean age 45 years, range 16-80 years) with duodenal ulcers (n = 18) or non-ulc ... | 1993 | 8485267 |
| [antigens for the elisa test for serodiagnosis of helicobacter pylori infection]. | semipurified urease and outer membranes of helicobacter pylori were isolated and used as antigens for the construction of new elisa tests for the serodiagnosis of infections caused by this microorganism. the highest discriminating capacity between infected and not infected subjects was obtained by the test detection of igg antibodies against the urease antigen which reached a 100% sensitivity, 90% specificity, a 100% negative and 91% positive predictive value. examination of sera of healthy chil ... | 1993 | 8485766 |
| [igg antibodies to gastrospirillum hominis and helicobacter pylori]. | in conjunction with an investigation extending over several years, focused on the understanding of the importance of helicobacter pylori in inflammatory gastric disease, the authors examined a group of 1242 patients. in fifteen they detected by microscopic examination the presence of helical bacteria described in the literature as gastrospirillum hominis. the cultivation test was not positive. in three patients in addition to these bacteria also the presence of helicobacter pylori was detected. ... | 1993 | 8485767 |
| [a study on acid resistance of helicobacter pylori]. | physiological saline solutions, each adjusted to ph 1.0, ph 2.0 and ph 7.2, and added urea and urease inhibitor (acetohydroxamic acid), were inoculated with a culture solution of helicobacter pylori nctc11637 strain derived from man, and allowed to react for 10, 30, 60 and 120 minutes. after five days of incubation on a blood agar medium, remaining viable h. pylori was counted. survival of h. pylori was inadequate under the conditions of ph 1.0 and ph 2.0, but survival up to 120 min was observed ... | 1993 | 8486976 |
| ultrastructure and biochemical studies of the flagellar sheath of helicobacter pylori. | helicobacter pylori flagellar sheaths were isolated by sucrose density-gradient centrifugation and analysed by electronmicroscopy, sds-page and gas-liquid chromatography. electronmicroscopy of thin sections of flagella showed an internal electron-dense filament and a surrounding flagellar sheath with the typical bilayer structure of a membrane. the flagellar filaments could be disintegrated by acid treatment and the resulting isolated flagellar sheaths formed vesicles, sometimes with characteris ... | 1993 | 8487294 |
| lethal nature of ischemic gastropathy. | gastropathy on the basis of mesenteric arterial ischemia can be masked in presentation as the typically more benign entities of gastritis, gastric ulceration, or gastric atony. gastritis and ulceration are commonly associated with stress, hyperacidity, helicobacter pylori infection, or medication injury. gastric atony is less commonly seen and usually attributable to diabetes mellitus, vagotomy, or mechanical gastric outlet obstruction. gastric ischemia as a cause of gastropathy is an underappre ... | 1993 | 8488953 |
| use of autoradiography to assess viability of helicobacter pylori in water. | autoradiographic methods have been developed to detect metabolic activity of viable but nonculturable cells of helicobacter pylori in water. four strains of h. pylori were studied by using microcosms containing suspensions of 72-h cultures in water. the suspensions of aged, nonculturable cells of h. pylori were incubated with [3h]thymidine for 24 to 72 h, after which the cell suspensions were exposed to kodak ntb2 emulsion for 3 to 28 days. each sample was processed with three separate controls ... | 1993 | 8489232 |
| proton pump inhibitors, enterochromaffin-like cell growth and helicobacter pylori gastritis. | in both rodents and humans the development of gastrin-promoted gastric argyrophil enterochromaffin-like cell carcinoids requires the involvement of a genetic factor inherent to multiple endocrine neoplasia syndrome or of type a autoimmune chronic atrophic gastritis. prolonged severe hypergastrinaemia acting on non-gastritic mucosa, as in zollinger-ellison syndrome patients, results in diffuse argyrophil enterochromaffin-like cell hyperplasia but, as a rule, does not produce tumours. combination ... | 1993 | 8490076 |
| future prospects for proton pump inhibitors. | future prospects for proton pump inhibitors depend on their efficacy and safety relative to h2-receptor antagonists, the therapeutic standard for acid peptic disorders. as safety concerns diminish, efficacy considerations become more important as these may pertain to cost effectiveness. comparative, controlled trials show that omeprazole and lansoprazole are somewhat more effective than h2-blockers in healing duodenal and gastric ulcers, providing faster relief of symptoms. relapse after cessati ... | 1993 | 8490082 |
| characteristics of the gastric mucosa of direct relatives of patients with sporadic gastric carcinoma. | we compared the gastric mucosa lesions of 63 direct relatives of 24 patients with gastric carcinoma with those observed in 151 dyspeptic patients and in seven members of a family with familial gastric carcinoma of diffuse type. we found a higher prevalence of helicobacter pylori infection (96.8%) and gastritis (98.4%) in the relatives of patients with sporadic carcinoma than in the dyspeptic patients. one-third of the individuals of the former group displayed chronic atrophic gastritis and intes ... | 1993 | 8490543 |
| gastric screening prospects. | the incidence of gastric cancer is rapidly declining in the western world, but it remains high in the third world and in japan. systematic screening for gastric cancer has been undertaken in japan, where barium x-ray is used in people over the age of 40. evaluation data suggest a benefit in reduced mortality, but biases cannot be ruled out. a similar screening programme has been started in venezuela. currently, stomach cancer screening programmes cannot be recommended as public health policy, ex ... | 1993 | 8490548 |
| serological diagnosis of helicobacter pylori--evaluation of four tests in the presence or absence of non-steroidal anti-inflammatory drugs. | the host's humoral immune response to helicobacter pylori has been used in the diagnosis of active infection with these organisms. several commercial tests are available but there are few and unconfirmed reports of their efficacy. this study aimed to assess and compare the efficacy of the following h pylori serological tests in patients treated or not treated with non-steroidal anti-inflammatory drugs (nsaid): pyloriset latex, helico-g, biolab malakit, and bio-rad gap test igg. venous blood was ... | 1993 | 8491390 |
| short and long term outcome of helicobacter pylori positive resistant duodenal ulcers treated with colloidal bismuth subcitrate plus antibiotics or sucralfate alone. | thirty two patients with helicobacter pylori positive duodenal ulcers resistant to treatment were randomly assigned to 4 weeks' treatment with sucralphate 4 g/day or colloidal bismuth subcitrate 480 mg/day plus amoxycillin from days 1 to 7 and tinidazole from days 8 to 14. after 4 weeks, patients with unhealed ulcers were crossed over to the other form of treatment for a further 4 week period. patients with healed ulcers were followed up for 1 year without maintenance therapy with clinical and e ... | 1993 | 8491391 |
| [helicobacter pylori and gastric mucosa]. | 1993 | 8492035 | |
| gastric heterotopic mucosa in the rectum with helicobacter pylori-like organisms: a rare cause of rectal bleeding. | we report the case of a 9-year-old boy who presented with chronic rectal bleeding. on proctosigmoidoscopy, a polypoid elevation in the rectal ampulla measuring 5 x 3 cm was found. biopsies were reported to show gastric mucosa. the giemsa stain showed helicobacter pylori-like organisms. including our patient, there are now 30 similar cases reported in the medical literature. the usual manifestations of this rare entity are chronic bleeding and rectal pain. in one-half of cases there is chronic re ... | 1993 | 8492046 |
| serodiagnosis of helicobacter pylori infection in children by an indirect immunofluorescence test. | the objective of this study was to evaluate the accuracy of an indirect immunofluorescence (iif) test for serodiagnosis of helicobacter pylori infection in children and to determine how the test is affected by the presence of antibodies against campylobacter jejuni. we studied 65 consecutive children (two with endoscopically confirmed duodenal ulcer) and a series of 18 children with duodenal ulcer. thirty children were h. pylori negative, as determined by culture, by the preformed urease test, a ... | 1993 | 8492250 |
| the prevalence of helicobacter pylori-positive serology in asymptomatic children. | epidemiologic data are presented about the prevalence of helicobacter pylori positivity as determined by serology in a large series of asymptomatic children (n = 466). serology is now generally accepted as a valid noninvasive screening method for the detection of helicobacter pylori infection. blood samples were taken from 466 apparently healthy children (ages 2-14 years) who were admitted to our pediatric 1-day clinic for elective surgery. the children originated from different ethnic backgroun ... | 1993 | 8492251 |
| upper gastrointestinal endoscopy in recurrent abdominal pain of childhood. | over a 2.5-year period, 82 consecutive children complaining of recurrent abdominal pain underwent upper gastrointestinal endoscopy. gastroscopy confirmed pathology in 48 of the children (58.5%). four of the children, who also had undergone gastroscopy, had other diagnoses (lactose malabsorption, hydronephrosis, yersiniosis), and 30 of the children (36.6%) retained the initial diagnosis of recurrent abdominal pain syndrome. gastritis was found in 48 of the children, 18 of whom (37.5%) had positiv ... | 1993 | 8492255 |
| [investigation of gastric function and prevalence of helicobacter pylori in non-ulcer dyspepsia]. | one hundred and fourty four patients with non-ulcer dyspepsia (nud), as defined by the working party of aga in 1987, (67 men and 77 women, 16-76 years, mean age 42.9 +/- 1.2 years) and 34 asymptomatic controls (25 men and 9 women, 17-75 years, mean age 50.6 +/- 2.4 years) parameters of gastrophysiological function (gastric acid secretion, postprandial gastric emptying-acetaminophen method, serum gastrin levels and cutaneous electrogastrography (egg)) and the prevalence of helicobacter pylori (hp ... | 1993 | 8492467 |
| potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of helicobacter pylori: unique action selective for h. pylori cells. | the gastric proton pump inhibitor lansoprazole, its active analog ag-2000, and omeprazole dose dependently inhibited urease activity extracted with distilled water from helicobacter pylori cells; the 50% inhibitory concentrations were between 3.6 and 9.5 microm, which were more potent than those of urease inhibitors, such as acetohydroxamic acid, hydroxyurea, and thiourea. these compounds also inhibited urease activity in intact cells of h. pylori and helicobacter mustelae but did not inhibit ur ... | 1993 | 8494373 |
| the phylogenetic position of helicobacter nemestrinae. | comparison of the helicobacter nemestrinae 16s ribosomal dna with published homologous sequences from members of the genera helicobacter, wolinella, and campylobacter reveals a close relationship between h. nemestrinae, h. pylori, and h. acinonyx. this finding is unexpected since these species differ significantly in their dna guanine-plus-cytosine contents (24 to 38 mol%). | 1993 | 8494747 |
| evaluation of quickvue, a rapid enzyme immunoassay test for the detection of serum antibodies to helicobacter pylori. | quickvue is an enzyme immunoassay test for qualitative detection of serum immunoglobulin-g antibodies to helicobacter pylori. we evaluated its ability to predict infection by h. pylori in 100 adult and 49 pediatric patients referred for gastric endoscopy. a patient was defined as infected with h. pylori if either culture or histology was positive. of the 100 adult patients, 64 had h. pylori infection and quickvue correctly identified 59 of the 64. of 36 h. pylori-negative patients, 20 were corre ... | 1993 | 8495587 |
| a human cdna corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. | a clone, designated pag, was isolated by differential screening of cdna libraries made from the untransformed and ras-transformed human mammary epithelial cell line hbl100. this cdna corresponds to a gene constitutively expressed in most human cells which is induced to higher levels upon serum stimulation in untransformed and ras-transformed hbl100 cells. however, the abundance of the pag transcript is approximately 3-fold higher in transformed as compared to untransformed cells after 7-15 h of ... | 1993 | 8496166 |
| antibacterial action of the urease inhibitor acetohydroxamic acid on helicobacter pylori. | the urease inhibitor acetohydroxamic acid (aha) was assessed for its bacteriostatic and bactericidal effects on helicobacter pylori. for eight isolates of h pylori, the minimum inhibitory concentration (mic) was either 200 mg/l or 400 mg/l. interactions between aha and antimicrobial drugs used to treat h pylori were also determined. for most isolates aha reduced the mic for colloidal bismuth subcitrate (cbs), tetracycline, metronidazole, and amoxicillin. in a few isolates, however, aha increased ... | 1993 | 8496397 |
| helicobacter pylori infection in adolescents with eating disorders and dyspeptic symptoms. | the potential role of helicobacter pylori infection of the antrum as a cause of symptoms of dyspepsia in patients with eating disorders was evaluated with an assay to detect h. pylori-specific igg in serum. h. pylori-specific optical-density readings were comparable for adolescents with eating disorders (0.133 +/- 0.063, mean +/- sd) and for two comparison groups, and were lower than readings for children with documented h. pylori infection. symptoms referable to the gastrointestinal tract did n ... | 1993 | 8496771 |
| [helicobacter pylori infection and duodeno-gastric reflux]. | we have studied and measured the duodenogastric reflux in 11 children with chronic abdominal pain and helicobacter pylori (hp) through 24-hours gastric ph-metric studies. all parameters evaluated: number of reflux episodes (nr 92.87 +/- 27.66), number of reflux episodes longer than 5.0 minutes (nr > 5m 11.45 +/- 4.68), longest reflux episode (lr 67.37 +/- 45.57) and alkaline reflux area (aa 604.89 +/- 443.54) had significative differences against a normal group (40 children). we concluded that d ... | 1993 | 8499232 |
| immunological activity of lipopolysaccharide of helicobacter pylori on human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria. | lipopolysaccharide of helicobacter pylori was tested for its mitogenicity and for its ability to stimulate cytokine release in human peripheral blood mononuclear cells (pbmc) of healthy and h. pylori-infected blood donors. mitogenicity in pbmc induced by h. pylori lps was similar to that induced by campylobacter jejuni lipopolysaccharide, but lower than that induced by escherichia coli lipopolysaccharide in the h. pylori negative blood donor group. furthermore, h. pylori lps was able to induce t ... | 1993 | 8499895 |
| cell-associated haemolytic activity of helicobacter pylori. | helicobacter pylori cells cultured on solid medium were quantitatively tested for haemolytic activity against erythrocytes of man, sheep, the guinea pig and rabbit. using 4-day and 8-day cultures of two standard strains (atcc 43504, immi 676), human erythrocytes were not lysed by 10% bacterial suspensions. rabbit erythrocytes were the most sensitive to 8-day cultures. hot-cold incubation yielded the highest haemolysis titres. the extent of haemolysis strongly correlated with the number of bacter ... | 1993 | 8500489 |
| [validation and clinical and epidemiological use of a serologic test recommended in the diagnosis of helicobacter pylori infection]. | a commercial serologic test using purified antigens of helicobacter pylori has been evaluated in the diagnosis of this infection. in a series of 250 patients undergoing endoscopy with antral biopsies for cytology, histology and culture, serology was positive in 68 of 71 patients with a positive culture (sensitivity: 96%) and negative in 67 of 69 patients with a normal mucosa and no microorganisms on biopsy (specificity: 97%). in the entire series, serology was positive in 33 patients with no inf ... | 1993 | 8500715 |
| antral g-cell and d-cell numbers in helicobacter pylori infection: effect of h. pylori eradication. | it has recently been recognized that helicobacter pylori infection is associated with abnormalities in the regulation of gastrin secretion. we investigated whether there was a relationship between h. pylori infection and g-cell and d-cell numbers. | 1993 | 8500723 |
| animal models for helicobacter pylori. | 1993 | 8500753 | |
| local and systemic immune responses in murine helicobacter felis active chronic gastritis. | helicobacter felis inoculated per os into germfree mice and their conventional non-germfree counterparts caused a persistent chronic gastritis of approximately 1 year in duration. mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infiltrates were detected as well. immunohistochemical analyses of gastric mucosa from h. felis-infected mice revealed the presence of mucosal b220+ cells coalescing into lymphoid follicles surrounded by ... | 1993 | 8500873 |
| receptor affinity purification of a lipid-binding adhesin from helicobacter pylori. | our previous work has shown that helicobacter pylori specifically recognizes gangliotetraosylceramide, gangliotriaosylceramide, and phosphatidylethanolamine in vitro. this binding specificity is shared by exoenzyme s from pseudomonas aeruginosa, and monoclonal antibodies against this adhesin prevent the attachment of h. pylori to its lipid receptors. we now report the use of a novel, versatile affinity matrix to purify a 63-kda exoenzyme s-like adhesin from h. pylori which is responsible for the ... | 1993 | 8500882 |
| expression of catalytically active recombinant helicobacter pylori urease at wild-type levels in escherichia coli. | the genes encoding helicobacter pylori urease, a nickel metalloenzyme, have been cloned and expressed in escherichia coli. enzymatic activity, however, has been very weak compared with that in clinical isolates of h. pylori. conditions under which near wild-type urease activity was achieved were developed. e. coli. se5000 containing recombinant h. pylori urease genes was grown in minimal medium containing no amino acids, nicl2 was added to 0.75 microm, and structural genes urea and ureb (php902) ... | 1993 | 8500893 |
| helicobacter mustelae and helicobacter pylori bind to common lipid receptors in vitro. | helicobacter pylori is a recently recognized human pathogen causing chronic-active gastritis in association with duodenal ulcers and gastric cancer. helicobacter mustelae is a closely related bacterium with similar biochemical and morphologic characteristics. h. mustelae infection of antral and fundic mucosa in adult ferrets causes chronic gastritis. an essential virulence property of both helicobacter species is bacterial adhesion to mucosal surfaces. the aim of this study was to determine whet ... | 1993 | 8500901 |