Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| hsv-1 vs. hsv-2 demographics. | 2004 | 15536801 | |
| exposure to urban pollutants and serum levels of igg anti herpes simplex virus type 1. | the aim of the study is to investigate whether traffic policemen exposed to urban pollutants and psycho-social stressors may be at risk of modifications in serum levels of immunoglobulins g antibodies (igg ab) against herpes simplex virus (type1) (hsv-1) compared with controls. traffic policemen were matched by sex, age, working life and drinking habits (less than two glasses of wine or beer per day) with controls, after excluding the subjects with the principal confounding factors (smoking habi ... | 2004 | 15540623 |
| efficient and non-toxic gene transfer to cardiomyocytes using novel generation amplicon vectors derived from hsv-1. | the feasibility of gene transfer to myocardial tissue using viral vectors was investigated over the last few years. in this study we report gene transfer using a recently described improved of herpes simplex virus (hsv-1)-derived amplicon vectors and demonstrate that these vectors are a powerful and potentially very interesting tool for gene transfer into neonatal primary as well as in adult cardiac myocytes. | 2004 | 15623439 |
| chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle. | it is shown that in spite of the low energy barrier for the north (n)/south (s) equilibrium in nucleosides, enzymes show measurable differences in binding and/or catalytic activity between the two antipodal conformations. | 2004 | 17150453 |
| synthesis and evaluation of 2'-deoxy-2'-18f-fluoro-5-fluoro-1-beta-d-arabinofuranosyluracil as a potential pet imaging agent for suicide gene expression. | 2'-deoxy-2'-(18)f-fluoro-5-fluoro-1-beta-d-arabinofuranosyluracil ((18)f-ffau) has been synthesized and evaluated in ht-29 cells as a potential pet agent for herpes simplex virus type 1 thymidine kinase (hsv1-tk) gene expression. | 2004 | 15585483 |
| [the synthesis and antiherpetic activity of acyclovir phosphonate esters]. | alkyl esters of acyclovir phosphite, alkoxycarbonylphosphonate, ethoxycarbonylmethylphosphonate, and aminocarbonylphosphonate were synthesized. most of them were shown to inhibit the replication of type 1 herpes simplex virus in vero cell culture. the stability in phosphate buffer and human blood serum was studied for several of the derivatives. a correlation between the stability and antiviral activity of the synthesized compounds is discussed. the english version of the paper: russian journal ... | 2004 | 15586811 |
| expression of cellular proteins bcl-x(l), xiap and bax involved in apoptosis in cells infected with herpes simplex virus 1 and effect of pavine alkaloid (-)-thalimonine on virus-induced suppression of apoptosis. | the expression of three cellular proteins involved in the modulation of apoptosis, namely antiapoptotic bcl-x(l) and xiap and proapoptotic bax, was investigated in cells infected with herpes simplex virus 1 (hsv-1). to assess whether the regulation of apoptosis in virus-infected cells depends on strain specificity the wild-type (wt) strain victoria and the mutant r-100 resistant to acyclovir (acv) were used. in addition, the expression of bcl-x(l), xiap and bax was studied in cells infected with ... | 2004 | 15595215 |
| herpes simplex virus-induced, death receptor-dependent apoptosis and regression of transplanted human cancers. | inoculation of a live attenuated herpes simplex virus (hsv) vector, betah1, into human u87mg glioblastoma cells transplanted into athymic nude mice induced complete regression of tumors. the infected cells underwent histochemically confirmed apoptosis without lymphocyte infiltration after expressing cd30, cd30 ligand (cd30l), tumor necrosis factor (tnf)-alpha, tnf receptor 1 (tnf-r1), fas, and fas ligand (fas-l) with activation of caspases 3 and 8. induction of the transcripts of these receptors ... | 2004 | 15596049 |
| epidemiological, clinical and laboratory aids for the diagnosis of neonatal herpes -- an australian perspective. | neonatal herpes is rare in australia, possibly because of the older average age at pregnancy compared with other developed countries, low herpes simplex virus (hsv)-2 seroprevalence in the general community, low risk of hsv-2 acquisition during pregnancy and relatively high hsv-1 seroprevalence in adults. guidelines on herpes management in pregnancy have been produced by the australian society for infectious diseases and endorsed by the australian college of obstetricians and gynaecologists. how ... | 2004 | 15955266 |
| inhibition of dna repair by a herpes simplex virus vector enhances the radiosensitivity of human glioblastoma cells. | expression of the herpes simplex virus (hsv) protein, icp0, from the viral genome, rendered two radioresistant human glioblastoma multiforme cell lines more sensitive to the effects of ionizing radiation. using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and clonogenic survival assays, u87-mg and t98 cell survival was more greatly decreased as a function of ionizing radiation dose when icp0 was preexpressed in cells compared with when icp0 was not expressed. consistent with ... | 2005 | 15958578 |
| analysis of a bovine herpesvirus 1 recombinant virus that does not express the bicp0 protein. | bovine herpesvirus 1 (bhv-1) infected-cell protein 0 (bicp0) stimulates productive infection by activating viral gene expression. in this study, an attempt was made to construct a recombinant virus with point mutations in the c(3)hc(4) zinc ring finger of bicp0, as this domain is necessary for activating viral transcription and productive infection. a virus was identified in bovine cells that induced small clusters of infected cells resembling a small plaque. instead of the expected mutations wi ... | 2005 | 15958678 |
| a microarray study to characterize the molecular mechanism of timp-3-mediated tumor rejection. | glial cell invasion is a multistep cellular process that involves a complex system of tightly regulated proteases (matrix metalloproteinases; mmps) and their endogenous inhibitors (tissue inhibitors of metalloproteinases; timps) to mediate the degradation of the basement membrane and extracellular matrix. tissue inhibitor of metalloproteinases-3 (timp-3) is a matrix-bound inhibitor of mmps. in the present study, we have overexpressed the timp3 gene in human glioma cells with a herpes simplex vir ... | 2005 | 15963930 |
| involvement of cellular death signals in the reactivation of herpes simplex virus type 1 and lambda bacteriophage from a latent state. | herpes simplex virus (hsv) 1 has adapted to the human host through two modes of infection, the acute-transient infection that may cause diseases (such as encephalitis) and the latent state, which is a source for recurrent infection and disease. while much information has been gathered on the cellular and molecular concomitants of establishment and maintenance of hsv-1 latent state, the biological basis of viral reactivation is still unclear. despite their obvious differences, hsv-1 and the bacte ... | 2005 | 15967186 |
| cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin iii, methyl (n-benzoyl-(2'r,3's)-3'-phenylisoserinate) and n-benzoyl-(2'r,3's)-3'-phenylisoserine. | the aim of this study was to evaluate cytotoxic, antiviral (in-vitro and in-vivo) and immunomodulatory activity, as well as the influence on mitotic division, of three taxol derivatives representing modified parts of its molecule: 10-deacetyl-baccatin iii, methyl (n-benzoyl-(2'r,3's)-3'-phenylisoserinate) and n-benzoyl(2'r,3's)-3'-phenylisoserine. the cytotoxicity of the compounds, assessed by the formazane method, was relatively low, with a 50% cytotoxic concentration (cc50)>500 microg ml-1. mo ... | 2005 | 15969936 |
| protein transduction of rab9 in niemann-pick c cells reduces cholesterol storage. | niemann-pick disease type c (npc) is a genetic disorder in which patient cells exhibit lysosomal accumulation of cholesterol and sphingolipids (sls) caused by defects in either npc1 or npc2 proteins. we previously demonstrated that npc1 human skin fibroblasts overexpressing endosomal rab proteins (rab7 or rab9) showed a correction in the storage disease phenotype. in the current study, we used protein transduction to further investigate rab9-mediated reduction of stored lipids in npc cells. reco ... | 2005 | 15972801 |
| physical signs for the general dental practitioner. | 2005 | 15977725 | |
| [comparison of adjuvant activities of glucosaminyl-muramyl dipeptide and of the gene coding for granulocyte-macrophage colony-stimulating factor in dna immunization against herpes simplex virus]. | adjuvant activities of granulocyte-macrophage colony-stimulating factor (gm-csf) and synthetic glucosaminyl-muramyl dipeptide (gmdp) were studied in immunization against type 1 herpes simplex virus (hsv1). gene encoding the gd hsv1 protein (pdnagd) was used as an immunogen. gene encoding gm-csf in pdnagm-csf plasmid, which was developed for eukaryotic expression, and gm-dp were used as immune response modulators. gmdp and plasmid dna with inserted gm-csf gene enhanced t-cell immune response to h ... | 2005 | 15981580 |
| a human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (e)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine. | (e)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine (ivfru) is a pyrimidine nucleoside analogue that accumulates selectively in murine cells expressing herpes simplex type-1 thymidine kinase (hsv-1 tk). the uptake of [(125)i]ivfru in human 143b osteosarcoma cells transduced with a retroviral vector bearing the hsv-1 tk gene (143b-ltk cells) is now reported. | 2005 | 15982576 |
| identification of proteins phosphorylated directly by the us3 protein kinase encoded by herpes simplex virus 1. | we have developed a system to analyze the specific protein kinase activity of herpes simplex virus 1 us3 in vitro and shown that us3 directly phosphorylates viral proteins ul34, icp22, and us9 and the cellular protein bad, previously reported to be putative substrates. using this system, we determined the phosphorylation sites of ul34 and identified ul31 as a previously unreported, novel substrate of us3. this system will be useful for further identification of us3 substrates and their phosphory ... | 2005 | 15994828 |
| critical role for the oligoadenylate synthetase/rnase l pathway in response to ifn-beta during acute ocular herpes simplex virus type 1 infection. | we previously demonstrated that ifn-beta transgene treatment protects mouse trigeminal ganglia (tg) cells from acute hsv-1 infection in vitro. however, ifn-alpha6 transgene treatment does not provide protection against acute hsv-1 infection in vitro, even though equivalent levels of ifn are expressed with both transgene treatments. in the present study we show that ifn-beta transgene treatment before acute ocular hsv-1 infection protects mice from hsv-1-mediated mortality, whereas ifn-alpha6 tra ... | 2005 | 16002711 |
| the nectin-1alpha transmembrane domain, but not the cytoplasmic tail, influences cell fusion induced by hsv-1 glycoproteins. | nectin-1 is a receptor for herpes simplex virus (hsv), a member of the immunoglobulin superfamily, and a cellular adhesion molecule. to study domains of nectin-1alpha involved in cell fusion, we measured the ability of nectin-1alpha/nectin-2alpha chimeras, nectin-1alpha/cd4 chimeras, and transmembrane domain and cytoplasmic tail mutants of nectin-1alpha to promote cell fusion induced by hsv-1 glycoproteins. our results demonstrate that only chimeras and mutants containing the entire v-like domai ... | 2005 | 16005040 |
| identification of a region in the herpes simplex virus scaffolding protein required for interaction with the portal. | the herpes simplex virus type 1 capsid is a protective shell that acts as a container for the genetic material of the virus. after assembly of the capsid, the viral dna is translocated into the capsid interior through a channel formed by the portal. the portal is composed of a dodecamer of ul6 molecules which form a ring-like structure found at a single vertex within the icosahedron. formation of portal-containing capsids minimally requires the four structural proteins (vp5, vp19c, vp23, and ul6 ... | 2005 | 15596809 |
| association of viral factors with non-familial breast cancer in taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. | to study the etiologic factors of non-familial breast cancer, the polymerase chain reaction (pcr) and southern hybridization were used to detect six viruses including human papillomavirus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpesvirus (hhv)-8 dna in 69 patients with breast cancer and 60 specimens from non-cancerous or other individuals with thyroid tumors or fibroadenoma (non-breast cancer controls). two specimens from patients ... | 2005 | 15602723 |
| glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide. | the chemically modified tripeptide glycyl-prolyl-glycine-amide (gpg-nh(2)) inhibits replication of human immunodeficiency virus (hiv) type 1 (hiv-1) in vitro, probably by interfering with capsid formation. the aim of the present study was to determine whether the metabolites glycyl-proline (gp-oh), glycine (g-oh), prolyl-glycine-amide (pg-nh(2)), proline (p-oh), and glycine-amide (g-nh(2)) from proteolytic cleavage may inhibit the replication of hiv-1 in vitro. pg-nh(2) has previously been shown ... | 2005 | 15616273 |
| ethnomedicinal uses of momordicacharantia (cucurbitaceae) in togo and relation to its phytochemistry and biological activity. | investigation of the traditional uses of momordica charantia (cucurbitaceae) in togo (west africa) showed that it is one of the most important local medicinal plants both for ritual and ethnomedical practices. there was a high degree of consensus (>50%) for use in the treatment of gastrointestinal and viral disease among 47 groups of village informants in the general population, while 19 traditional healers reported a larger and broader set of uses. the use by informants in gaur and kwa language ... | 2005 | 15588650 |
| imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography. | molecular imaging of a suicide transgene's expression will aid the development of efficient and precise targeting strategies, and imaging for cancer cell viability may assess therapeutic efficacy. we used the pet reporter probe, 9-(4-[18f]fluoro-3-(hydroxymethyl)butyl)guanine ([18f]fhbg) to monitor the expression of a mutant herpes simplex virus 1 thymidine kinase (hsv1-sr39tk) in c6 glioma tumors implanted subcutaneously in nude mice that were repetitively being treated with the pro-drug gancic ... | 2005 | 15592447 |
| serum-resistant gene transfer to oral cancer cells by metafectene and genejammer: application to hsv-tk/ganciclovir-mediated cytotoxicity. | cationic lipids and polyamines have been used as non-viral gene transfer reagents, both in vitro and in vivo. one of the limitations to their use in vivo is the inhibition of gene delivery by serum. we showed previously that, in the absence of serum, relatively high cytotoxicity in oral cancer cell lines could be achieved via transfection of the herpes simplex virus thymidine kinase (hsv-tk) gene followed by treatment with ganciclovir (gcv), despite the low efficiency of transfection (konopka et ... | 2005 | 16217556 |
| [detection of sexually transmitted pathogens in patients with hematospermia]. | although the current literature attributes most cases of hematospermia to an infectious agent, identification of the specific pathogens involved has been limited. | 2005 | 16218534 |
| herpes simplex virus type 1 immediate-early protein icp0 diffuses out of infected rabbit corneas. | herpes stromal keratitis (hsk) results from infection of herpes simplex virus (hsv) in the cornea. recurrent hsv infection is a leading cause of corneal scarring and visual loss. although it is generally thought that hsk is the result of an immune response to one or more viral proteins, no viral proteins have been detected in hsk corneas. thus, the viral proteins involved in hsk, if any, remain undetermined. in contrast, it is reported here that when hsk corneal buttons from latently infected ra ... | 2005 | 16227219 |
| characterization of a highly glycosylated form of the human cytomegalovirus hla class i homologue gpul18. | human cytomegalovirus (hcmv) gpul18 is a hla class i (hla-i) homologue with high affinity for the inhibitory receptor lir-1/ilt2. the previously described 67 kda form of gpul18 is shown here to be sensitive to endoglycosidase-h (endoh). a novel form of gpul18 with a molecular mass of approximately 160 kda and resistance to endoh was identified in cells infected with hcmv strain ad169 or the low passage hcmv isolates merlin and toledo. the 67 kda endoh-sensitive gpul18 glycoform was detected earl ... | 2005 | 16227221 |
| herpes simplex virus type 1 glycoprotein e is required for axonal localization of capsid, tegument, and membrane glycoproteins. | herpes simplex virus type 1 (hsv-1) glycoprotein e (ge) promotes cell-to-cell spread at basolateral surfaces of epithelial cells, but its activity in neurons is less clear. we used the mouse retina infection model and neuronal cell cultures to define the spread phenotype of ge mutant viruses. wild-type (wt) and ge-null (ns-genull) viruses both infected retina ganglion cell neurons; however, ns-genull viral antigens failed to reach the optic nerve, which indicates a defect in axonal localization. ... | 2005 | 16227258 |
| herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. | to report 2 cases of herpes simplex keratitis misdiagnosed as rheumatoid arthritis (ra)-related peripheral ulcerative keratitis (puk), where isolation of the herpes simplex virus (hsv) led to a complete modification in management. | 2005 | 16227854 |
| assessment of viral and non-viral gene transfer into adult rat brains using hsv-1, calcium phosphate and pei-based methods. | cns gene transfer could provide new approaches to the modelling of neurodegenerative diseases and devising potential therapies. one such disorder is parkinson's disease (pd), in which dysfunction of several different metabolic processes has been implicated. here we review the literature on gene transfer systems based on herpes simplex virus type 1 (hsv-1) and non-viral polyethyleneimine (pei) and calcium phosphate nanoparticle methods. we also assess the usefulness of various cns gene delivery m ... | 2005 | 16228947 |
| hsv-1-based amplicon vectors: design and applications. | amplicons are defective, helper-dependent herpes simplex virus type 1 (hsv-1)-based vectors able to convey more than 100 kbp of foreign dna to the nucleus of mammalian cells. this unique feature make amplicons very appealing for preventive or therapeutic gene transfer requiring the transduction of very large pieces of dna, as well as for upstream fundamental studies, such as functional genomics. several recent achievements in amplicon technology have allowed to produce relatively large amounts o ... | 2005 | 16231049 |
| synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir. | the purpose of this study was to synthesize a series of diester prodrugs of ganciclovir (gcv), for improving ocular and oral bioavailability and therapeutic activity. solubility, logp, ph stability profile, in vitro antiviral activity, cytotoxicity, inhibition profile and ocular tissue hydrolysis of the gcv prodrugs were measured. val-val-gcv and val-gly-gcv diesters were found to exhibit greater aqueous stability compared to val-gcv and gly-val-gcv while ocular tissue hydrolysis demonstrated va ... | 2005 | 16242278 |
| herpes encephalitis preceded by ipsilateral vestibular neuronitis. | a 74-year-old woman developed vertigo and jerk nystagmus to the left with normal cerebral imaging. three days later she developed fever, altered mental state and left medial temporal lobe hypodensity, confirmed on lumbar puncture to be due to herpes simplex type 1 encephalitis. we propose that the patient had vestibular neuronitis caused by hsv-1 that progressed to ipsilateral temporal lobe encephalitis. | 2005 | 16246566 |
| binding of herpes simplex virus-1 us11 to specific rna sequences. | herpes simplex virus-1 us11 is a rna-binding protein with a novel rna-binding domain. us11 has been reported to exhibit sequence- and conformation-specific rna-binding, but the sequences and conformations important for binding are not known. us11 has also been described as a double-stranded rna (dsrna)-binding protein. to investigate the us11-rna interaction, we performed in vitro selection of rna aptamers that bind us11 from a rna library consisting of >10(14) 80 base sequences which differ in ... | 2005 | 16246910 |
| transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. | to study matrix metalloproteinases (mmp) and tissue inhibitors of metalloproteinases (timp) in the corneas from mice with ulcerative herpes stromal keratitis (hsk) treated with amniotic membrane transplantation (amt). | 2005 | 16249483 |
| enzymatic redesigning of biologically active heparan sulfate. | heparan sulfate carries a wide range of biological activities, regulating blood coagulation, cell differentiation, and inflammatory responses. the sulfation patterns of the polysaccharide are essential for the biological activities. in this study, we report an enzymatic method for the sulfation of multimilligram amounts of heparan sulfate with specific functions using immobilized sulfotransferases combined with a 3'-phosphoadenosine 5'-phosphosulfate regeneration system. by selecting appropriate ... | 2005 | 16260789 |
| 5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. | oncolytic herpes viruses are attenuated, replication-competent viruses that selectively infect, replicate within, and lyse cancer cells and are highly efficacious in the treatment of a wide variety of experimental cancers. the current study seeks to define the pharmacologic interactions between chemotherapeutic drugs and the oncolytic herpes viral strain nv1066 in the treatment of pancreatic cancer cell lines. the human pancreatic cancer cell lines hs 700t, panc-1, and mia paca-2 were treated in ... | 2005 | 16269377 |
| mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. | the aim of this study was to assess the efficacy human mesenchymal stem cells (hmsc) for targeting microscopic tumors and suicide gene or cytokine gene therapy. immunodeficient mice were transplanted s.c. with human colon cancer cells of ht-29 inv2 or ccs line, and 3 to 4 days later, i.v. with "tracer" hmscs expressing herpes simplex virus type 1 thymidine kinase (hsv1-tk) and enhanced green fluorescent protein (egfp) reporter genes. subsequently, these tumors were examined for specificity and m ... | 2005 | 16278396 |
| herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. | the program of gene expression exhibited by herpes simplex virus during productive infection of cultured cells is well established; however, less is known about the regulatory controls governing reactivation from latency in neurons. one difficulty in examining gene regulation during reactivation lies in distinguishing between events occurring in initial reactivating cells versus events occurring in secondarily infected cells. thus, two inhibitors were employed to block production of infectious v ... | 2005 | 16282451 |
| the neuronal host cell factor-binding protein zhangfei inhibits herpes simplex virus replication. | during lytic infection in epithelial cells the expression of herpes simplex virus type 1 (hsv-1) immediate-early (ie) genes is initiated by a multiprotein complex comprising the virion-associated protein vp16 and two cellular proteins, host cellular factor (hcf) and oct-1. oct-1 directly recognizes taatgarat elements in promoters of ie genes. the role of hcf is not clear. hsv-1 also infects sensory neurons innervating the site of productive infection and establishes a latent infection in these c ... | 2005 | 16282471 |
| adeno-associated virus-mediated bone morphogenetic protein-7 gene transfer induces c2c12 cell differentiation into osteoblast lineage cells. | to investigate the effects of bone morphogenetic protein-7 (bmp7)-expressing recombinant adeno-associated virus (aav) vector on the differentiation of c2c12 cells. | 2005 | 16038629 |
| epidemiology of genital herpes simplex virus infections in a community-based sample in france: results of the herpimax study. | the objective of this study was to provide information on the prevalence of herpes simplex infections in the general population in europe. | 2005 | 16041253 |
| synthesis of linear, branched, and cyclic peptide chimera. | chimeric peptides are unnatural constructs consisting of bioactive compounds from at least two different peptide(s) and/or protein(s) or two sequences from different parts of the same protein. such multifunctional peptide combinations are prepared to enhance the biological activity or selectivity of their components. new biological effects can also be achieved with the chimera. in this chapter the synthesis of three different types of chimeric peptides will be described. in a linear chimera, two ... | 2005 | 16044540 |
| herpes simplex virus type 2 ul24 gene is a virulence determinant in murine and guinea pig disease models. | a herpes simplex virus type 2 (hsv-2) ul24 beta-glucuronidase (ul24-betagluc) insertion mutant was derived from hsv-2 strain 186 via standard marker transfer techniques. cell monolayers infected with ul24-betagluc yielded cytopathic effect with syncytium formation. ul24-betagluc replicated to wild-type viral titers in three different cell lines. ul24-betagluc was not virulent after intravaginal inoculation of balb/c mice in that all inoculated animals survived doses up to 400 times the 50% letha ... | 2005 | 16051842 |
| herpes keratitis in the absence of anterograde transport of virus from sensory ganglia to the cornea. | herpes stromal keratitis is an immunopathologic disease in the corneal stroma leading to scarring, opacity, and blindness, and it is an important problem in common corneal surgeries. paradoxically, virus antigens are largely focused in the epithelial layer of the cornea and not in the stromal layer, and viral antigens are eliminated before stromal inflammation develops. it is not clear what drives inflammation, whether viral antigens are necessary, or how viral antigens reach the stroma. it has ... | 2005 | 16055558 |
| plasmacytoid dcs help lymph node dcs to induce anti-hsv ctls. | antiviral cell-mediated immunity is initiated by the dendritic cell (dc) network in lymph nodes (lns). plasmacytoid dcs (pdcs) are known to migrate to inflamed lns and produce interferon (ifn)-alpha, but their other roles in antiviral t cell immunity are unclear. we report that ln-recruited pdcs are activated to create local immune fields that generate antiviral cytotoxic t lymphocytes (ctls) in association with lndcs, in a model of cutaneous herpes simplex virus (hsv) infection. although pdcs a ... | 2005 | 16061729 |
| the first 30 minutes in the life of a virus: unrest in the nucleus. | on entry of viral dna into cells, a competition ensues between cellular factors that silence viral genes and transcriptional factors that block silencing and transcribe the dna. in the case of herpes simplex virus 1, the first set of genes expressed after infection-are induced by a viral protein (alphatif or vp16). expression of later (beta,gamma) genes in cells infected at low ratios of virus per cells requires a transcriptional activator (icp4) that cannot block silencing and a protein, icp0, ... | 2005 | 16082207 |
| broad spectrum anti-infective potential of xanthohumol from hop (humulus lupulus l.) in comparison with activities of other hop constituents and xanthohumol metabolites. | this review summarizes the capacity of xanthohumol (xn) in comparison with additional hop constituents and metabolites to act as an antiinfective agent against microorganisms including bacteria, viruses, fungi and malarial protozoa. xn was shown to inhibit the gram-positive bacteria staphylococcus aureus and streptococcus mutans. antiviral activity was demonstrated against bovine viral diarrhea virus, cytomegalovirus, herpes simplex virus type 1 and 2 and human immunodeficiency virus 1. inhibiti ... | 2005 | 16092071 |
| common use of inaccurate antibody assays to identify infection status with herpes simplex virus type 2. | in recent proficiency testing of herpes simplex virus type-specific serologic evidence by the college of american pathologists, commercially available herpes simplex virus antibody assays that were not glycoprotein-g based demonstrated high false-positive rates (14%-88%) for herpes simplex virus type-2 antibodies in sera that were positive for herpes simplex virus type-1 antibodies but negative for herpes simplex virus type-2 antibodies. herpes simplex virus serologic testing should be performed ... | 2005 | 16098855 |
| reduced immune responses after vaccination with a recombinant herpes simplex virus type 1 vector in the presence of antiviral immunity. | due to the continuous need for new vaccines, viral vaccine vectors have become increasingly attractive. in particular, herpes simplex virus type 1 (hsv-1)-based vectors offer many advantages, such as broad cellular tropism, large dna-packaging capacity and the induction of pro-inflammatory responses. however, despite promising results obtained with hsv-1-derived vectors, the question of whether pre-existing virus-specific host immunity affects vaccine efficacy remains controversial. for this rea ... | 2005 | 16099897 |
| characterization of the triplet repeats in the central domain of the gamma134.5 protein of herpes simplex virus 1. | the gamma134.5 protein of herpes simplex virus 1 (hsv-1) consists of an amino-terminal domain, a central domain with triplet repeats (ala-thr-pro) and a carboxyl-terminal domain. the triplet repeats are a unique feature of the gamma134.5 protein encoded by hsv-1, but the number of repeats varies among different strains. notably, the central domain containing the triplet repeats is implicated in neuroinvasion. in this report, it has been shown that partial or full deletion of triplet repeats, i.e ... | 2005 | 16099898 |
| polymerase chain reaction for diagnosis of genital herpes: a missed opportunity? | this study audited the utilization of herpes simplex virus polymerase chain reaction (hsv pcr) in the investigation of recurrent anogenital ulceration at the mortimer market centre. clinic guidelines for use of hsv pcr were modified in april 2003 to expand pcr use. ninety-six case-notes belonging to patients presenting with recurrent anogenital ulceration between 1 april and 16 october 2003 were reviewed and 59 were suitable for inclusion. details of the investigations carried out at each visit ... | 2005 | 16105194 |
| a deubiquitinating enzyme encoded by hsv-1 belongs to a family of cysteine proteases that is conserved across the family herpesviridae. | we have discovered a ubiquitin (ub)-specific cysteine protease encoded within the n-terminal approximately 500 residues of the ul36 gene product, the largest (3164 aa) tegument protein of herpes simplex virus 1 (hsv-1). enzymatic activity of this fragment, ul36usp, is detectable only after cleavage of ul36usp from full-length ul36 and occurs late during viral replication. ul36usp bears no homology to known deubiquitinating enzymes (dubs) or ub binding proteins. sequence alignment of the large te ... | 2005 | 16109378 |
| neonatal herpes should be a reportable disease. | neonatal herpes is a devastating disease, the most serious complication of genital herpes, one of the most common serious congenital or perinatal infections, and the most frequent complication of sexually transmitted infections among children. nevertheless, neonatal herpes is not reportable to health authorities in most states. the potential for prevention has been enhanced by recent diagnostic and therapeutic advances, and the disease meets widely accepted criteria for reporting, including inci ... | 2005 | 16118598 |
| the impact of skin disease following renal transplantation on quality of life. | the immunosuppressive therapy a patient requires to sustain a functioning renal allograft in the long term is associated with various skin complications. while quality of life (qol) after renal transplantation has been studied, no publications document the effect of post-transplant dermatological complications on qol. | 2005 | 16120145 |
| technology evaluation: nv-1020, medigene. | nv-1020 is a recombinant oncolytic hsv-based virus, in development by medigene (formerly neurovir) for the potential treatment of cancer. the therapy is currently undergoing phase ii clinical trials. | 2005 | 16121703 |
| stable levels of long-term transgene expression driven by the latency-associated transcript promoter in a herpes simplex virus type 1 vector. | previous gene transfer studies of the herpes simplex virus type 1 (hsv-1) using the latency-associated transcript (lat) promoter have reported a decrease in transgene expression in the brain over time, but the extent of this decrease has not been measured and it is unknown if expression eventually stabilizes. we examined lat promoter-mediated transgene expression in the mouse brain for 1 year following intracranial injection with a hsv-1 vector expressing human beta-glucuronidase (gusb). the vec ... | 2005 | 16122987 |
| effect of resveratrol on herpes simplex virus vaginal infection in the mouse. | resveratrol (3,5,4'-trihydroxystilbene) is a natural component of certain foods, such as grapes, that, when topically applied, has been shown to limit hsv-1 lesion formation in the skin of mice [antiviral res. 61:19-26, 2004]. to determine if it is active on genital hsv infection, the vagina of mice were infected with hsv-2 or hsv-1 and treated with a cream formulation of resveratrol. mice were evaluated daily for extravaginal disease and vaginal swabs were taken regularly and assayed for infect ... | 2005 | 16125258 |
| structural analysis and antiviral activity of a sulfated galactan from the red seaweed schizymenia binderi (gigartinales, rhodophyta). | aqueous extraction of gametophytic schizymenia binderi afforded a polysaccharide composed of galactose and sulfate groups in a molar ratio of 1.0:0.89 together with uronic acids (6.8 wt%) and minor amounts of other neutral sugars. alkali-treatment of the polysaccharide afforded a polysaccharide devoid of 3,6-anhydrogalactose. 13c nmr spectroscopy of the desulfated alkali-treated polysaccharide showed a backbone structure of alternating 3-linked beta-d-galactopyranosyl and 4-linked alpha-galactop ... | 2005 | 16125685 |
| [is prevention of reactivation of herpes simplex 1 virus necessary in cosmetic surgery and dermatological procedures?]. | 2005 | 16130033 | |
| the role of icp0-null hsv-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma. | oncolytic viruses that selectively replicate in cancer cells have been described for over 50 years. despite the observation by several groups that multimutated herpes simplex type 1 vectors are oncolytic in a variety of murine tumor models, the oncolytic potential of icp0 null mutants has not been described. this study characterizes a novel second-generation oncolytic herpes simplex type 1 vector null for the icp0 gene. we tested three mutant viruses and found that all were selectively cytotoxic ... | 2005 | 16140040 |
| in vivo kinetics of gitr and gitr ligand expression and their functional significance in regulating viral immunopathology. | this report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (gitr) and gitr ligand (gitr-l) in the immuno-inflammatory response to infection with herpes simplex virus (hsv). both gitr and gitr-l were transiently upregulated after ocular hsv infection, on antigen-specific t cells and antigen-presenting cells, respectively, in the draining lymph node (dln). in addition, virus-specific t-cell responses in the dln and spleen were enhanced by anti-gitr ... | 2005 | 16140769 |
| the extracellular domain of herpes simplex virus ge is indispensable for efficient cell-to-cell spread: evidence for ge/gi receptors. | herpes simplex virus (hsv) spreads rapidly and efficiently within epithelial and neuronal tissues. the hsv glycoprotein heterodimer ge/gi plays a critical role in promoting cell-to-cell spread but does not obviously function during entry of extracellular virus into cells. thus, ge/gi is an important molecular handle on the poorly understood process of cell-to-cell spread. there was previous evidence that the large extracellular (et) domains of ge/gi might be important in cell-to-cell spread. fir ... | 2005 | 16140775 |
| a herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse. | the latency-associated transcript (lat) is essential for the wild-type herpes simplex virus type 1 (hsv-1) high-reactivation phenotype since lat- mutants have a low-reactivation phenotype. we previously reported that lat can decrease apoptosis and proposed that this activity is involved in lat's ability to enhance the hsv-1 reactivation phenotype. the first 20% of the primary 8.3-kb lat transcript is sufficient for enhancing the reactivation phenotype and for decreasing apoptosis, supporting thi ... | 2005 | 16160155 |
| reciprocal activities between herpes simplex virus type 1 regulatory protein icp0, a ubiquitin e3 ligase, and ubiquitin-specific protease usp7. | herpes simplex virus type 1 (hsv-1) regulatory protein icp0 stimulates lytic infection and the reactivation of quiescent viral genomes. these roles of icp0 require its ring finger e3 ubiquitin ligase domain, which induces the degradation of several cellular proteins, including components of promyelocytic leukemia nuclear bodies and centromeres. icp0 also interacts very strongly with the cellular ubiquitin-specific protease usp7 (also known as hausp). we have shown previously that icp0 induces it ... | 2005 | 16160161 |
| valacyclovir to expedite the clearance of recurrent herpes gladiatorum. | to determine if valacyclovir usage expedites the clearance of recurrent herpes gladiatorum (hg) in wrestlers. | 2005 | 16162997 |
| immunity in latent herpes simplex virus infection. | immune responses against productive herpes simplex virus 1 (hsv-1) and/or herpes simplex virus 2 (hsv-2) (hsv) infection together with associated immune escape mechanisms are to a great degree understood. due to a limited rna expression and lacking a convincing evidence for production of virus proteins during latency, hsv in latently infected neurons had been for a long period considered invisible to immune system. this review analyzes currently accumulating data indicating an important role of ... | 2005 | 16178513 |
| adenovirus-directed ocular innate immunity: the role of conjunctival defensin-like chemokines (ip-10, i-tac) and phagocytic human defensin-alpha. | adenovirus (ad), a major cause of viral conjunctivitis worldwide, is controlled initially by the innate immune response on the ocular surface. in the present study, cultured human conjunctival epithelial cells were used to identify host genes responsive to infection by a clinical isolate of ad5, and the antiviral activity of some of their peptide products was investigated. | 2005 | 16186347 |
| identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection. | herpes simplex virus 1 (hsv-1) replicates in the nucleus of host cells and radically alters nuclear architecture as part of its replication process. replication compartments (rcs) form, and host chromatin is marginalized. chromatin is later dispersed, and rcs spread past it to reach the nuclear edge. using a lamin a-green fluorescent protein fusion, we provide direct evidence that the nuclear lamina is disrupted during hsv-1 infection and that the ul31 and ul34 proteins are required for this. we ... | 2005 | 16188986 |
| virus infection switches tlr-3-positive human neurons to become strong producers of beta interferon. | to study the capacity of human neurons to mount innate immunity responses to viral infections, we infected cells of a human postmitotic neuron-derivative cell line, nt2-n, with rabies virus (rabv) and herpes simplex type 1 (hsv-1). changes in neuronal gene expression were analyzed by use of affymetrix microarrays. applying a twofold cutoff, rabv increased the transcription of 228 genes, and hsv-1 increased the transcription of 263 genes. the most striking difference between the two infections co ... | 2005 | 16188991 |
| characterization of hpv-16 e6 dna vaccines employing intracellular targeting and intercellular spreading strategies. | human papillomavirus (hpv) e6 and e7 are consistently expressed and are responsible for the malignant transformation of hpv-associated lesions. thus, e6 and e7 represent ideal targets for therapeutic hpv vaccine development. we have previously used the gene gun approach to test several intracellular targeting and intercellular spreading strategies targeting hpv-16 e7. these strategies include the use of the sorting signal of lysosome-associated membrane protein (lamp-1), mycobacterium tuberculos ... | 2005 | 16200349 |
| immune control of hsv-1 latency. | a hallmark of the herpes family of viruses is their ability to cause recurrent disease. upon primary infection, herpes simplex virus (hsv) establishes a latent infection in sensory neurons that persists for the life of the individual. reactivation of these latent viral genomes with virion formation is the source of virus for most hsv recurrent disease. this review details recent exciting findings supporting a role for the host immune system, particularly cd8+ t cells in maintaining hsv-1 in a la ... | 2005 | 16212525 |
| synthesis and antiviral activity of some 2-substituted 3-formyl- and 3-cyano-5,6-dichloroindole nucleosides. | a series of dichlorinated indole nucleosides has been synthesized and tested for activity against human cytomegalovirus (hcmv) and herpes simplex virus type-1 (hsv-1) and for cytotoxicity. the isopropylidene-protected analogs of the previously reported 3-formyl-2,5,6-trichloro-1-(beta-dribofuranosyl)indole (ftcri) and 3-cyano-2,5, 6-trichloro-1-(beta-d-ribofuranosyl)indole (ctcri) were modified by nucleophilic displacement of the 2-chloro substituent using secondary amines. deprotection of the i ... | 2005 | 16438038 |
| involvement of three mucous membranes in herpes-induced recurrent erythema multiforme. | 2005 | 15627109 | |
| a novel role for neutrophils as a source of t cell-recruiting chemokines ip-10 and mig during the dth response to hsv-1 antigen. | analogous to cd4+ t cells, neutrophils are essential participants in delayed-type hypersensitivity (dth) to herpes simplex virus type 1 antigen. however, what role they play in this cellular immune response is unclear. the recent recognition that neutrophils are potent producers of chemokines led us to hypothesize that they may help recruit cd4+ effector t cells. in the present study, we show that neutrophil depletion was accompanied by a marked decrease in the numbers of cd4+ and cxc receptor 3 ... | 2005 | 15629884 |
| intratypic variations among thai herpes simplex virus (hsv) isolates determined by restriction fragment length polymorphism (rflp) analysis. | whole genomic polymorphisms for 20 hsv-1 and 20 hsv-2 isolates from thai patients were analyzed by means of restriction fragment length polymorphism (rflp) analysis using 4 restriction endonucleases: bamhi, kpnl, hindiii, and ecori. variations in cleavage sites among the hsv-1 and hsv-2 isolates were compared to the cleavage patterns of standard hsv-1 strain kos and hsv-2 strain baylor 186. although 70% of hsv-1 isolates with bamhi digestion, 50% with kpnl, 75% with hindiii and 70% with ecori di ... | 2005 | 16295545 |
| herpes simplex encephalitis. | 2005 | 16018163 | |
| [elisa study on application of recombinant glycoprotein d of herpes simplex virus-1 in diagnosis of herpes simplex virus-1 infection with elisa]. | to establish a specific and sensitive serological elisa, diagnostic method, for herpes simplex virus-1 (hsv-1) infection using yeast expressed glycoprotein d (gd) of hsv-1 as coating antigen. | 2005 | 16027786 |
| [vp22 enhances the immunological activity of human cytomegalovirus pp65 dna vaccine: experimental study with mice]. | to construct the human cytomegalovirus (hcmv) pp65 dna vaccine vector and vp22 and pp65 coexpressing vector. to evaluate and compare immunological effects in mice. | 2005 | 16029549 |
| high susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection. | more than 20 infectious agents, ranging from retroviruses to mycobacteria, have been associated with multiple sclerosis onset or relapses in which oligodendrocytes, the myelin-forming cells of the central nervous system, are the initial target of the pathogenic status. in this work, the nature of the susceptibility of the human precursor oligodendroglial kg-1c cell line to herpes simplex virus type 1 (hsv-1) was investigated. infection of kg-1c cells was characterized by a high level of virus pr ... | 2005 | 16036797 |
| triple gene-deleted oncolytic herpes simplex virus vector double-armed with interleukin 18 and soluble b7-1 constructed by bacterial artificial chromosome-mediated system. | conditionally replicating herpes simplex virus type 1 (hsv-1) vectors are promising therapeutic agents for cancer. certain antitumor functions may be added to oncolytic activities of recombinant hsv-1 vectors by inserting transgenes into the viral genome. because conventional homologous recombination techniques had required time-consuming processes to create "armed" oncolytic hsv-1 vectors, we established an innovative construction system using bacterial artificial chromosome and two recombinase ... | 2005 | 16322208 |
| [mesenchymal dysplasia of heart valves, cystic medianecrosis of the aorta and herpetic infection]. | histologic and immunohistochemical studies (use of antibodies for viruses of herpes simplex type 1 and 2, desmin, vimentin, sma as well as polymerase chain reaction to dna of viruses of herpes simplex) were made on the material of the valves taken from 1326 patients with valvular heart disease, the ascending aorta of 30 patients with aneurysm, valves of 35 deceased patients without cardiovascular pathology. as a result, expression of viruses of herpes simplex type 1 and/or 2 was found in all cas ... | 2005 | 16323474 |
| pathogenesis of herpes simplex hepatitis in macrophage-depleted mice: possible involvement of tumor necrosis factor-alpha and inducible nitric oxide synthase in massive apoptosis. | massive liver cell death provoked in silica-treated mice subsequently infected with herpes simplex virus (hsv)-1 is very similar pathohistologically to the cell death observed in human fulminant hepatitis. previously, we have shown this liver cell death to be extensive apoptosis. in the present study, we examined various factors related to liver damage patho- and immunologically, as well as by reverse transcription-polymerase chain reaction. tumor necrosis factor (tnf)-alpha, inducible nitric ox ... | 2005 | 16333916 |
| antiherpetic activities of flavonoids against herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in vitro. | flavonoids, a group of low molecular weight phenylbenzopyrones, have various pharmacological properties including antioxidant, anticancer, bactericidal, and anti-inflammatory. we carried out anti-herpetic assays on 18 flavonoids in five classes and a virus-induced cytopathic effect (cpe) inhibitory assay, plaque reduction assay, and yield reduction assay were performed. when flavonoids were applied at various concentrations to vero cells infected by hsv-1 and 2, most of the flavonoids showed inh ... | 2005 | 16350858 |
| synthesis and antiviral evaluation of novel 4'-hydroxymethyl branched thioapiosyl nucleosides. | in this study, we synthesized novel 4'-hydroxymethyl branched thioapiosyl nucleosides. the thioapiosyl sugar moiety was constructed using sequential ozonolysis and reduction. the natural bases (uracil, thymine, cytosine, and adenine) were efficiently coupled using the vorbrüggen glycosyl condensation procedure (persilyated base and tmsotf). the antiviral activities of the synthesized compounds were evaluated against hiv-1, hsv-1, hsv-2, and hcmv. compound 19 showed moderate anti-hiv activity (ec ... | 2005 | 16353276 |
| role of mucosal immunity in preventing genital herpes infection. | the female genital tract is immunologically unique because it must be tolerant to spermatozoa, pregnancy, and vaginal flora, but also protect the host from pathogen challenge. the mucosal response to herpes simplex viruses (hsv), a major cause of genital ulcerative disease and critical co-factor in the hiv/aids epidemic, is complex and consists of the normally acidic vaginal environment, constitutively secreted and induced antimicrobial peptides, complement, and cellular responses mediated by ep ... | 2005 | 16359226 |
| [synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives]. | new 5-azole- and 5-oxime-substituted analogues of 2'-deoxyuridine are synthesized. the analogues with azole ring manifest low toxicities and antiherpetic activities on vero cell culture, the imidazole derivative being the most active. the inhibitory effects of oximes of 5-formyl-deoxyuridine are comparable with those of the azole-containing nucleoside analogues, although their cytotoxicities are found to be higher; oxime of 5-formyldeoxyuridine is particularly toxic. the nucleoside analogues syn ... | 2005 | 16363134 |
| dipeptide monoester ganciclovir prodrugs for treating hsv-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. | the aim of this study was to evaluate a series of dipeptide monoester ganciclovir (gcv) prodrugs with the goal of improving ocular bioavailability of gcv from topical ophthalmic solutions. | 2005 | 16386088 |
| interstitial cystitis and infectious agents. | interstitial cystitis (ic) is a syndrome consisting of severe refractory bladder symptoms of unknown etiology. the disease tends to affect caucasian women with a mean age of 40 years, with 25% of patients under the age of 30. few population based epidemiological studies of ic have been performed. we analyzed a case of interstitial cystitis in a 42-year-old non-smoker woman. in two biopsy samples the presence of viral dna of human polyomavirus bk (bkv), human herpes virus type 1 and type 2 (hhv- ... | 2005 | 16388730 |
| fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo. | the clinical success of suicide gene therapy using herpes simplex virus type 1 thymidine kinase (tk) is largely dependent on the capacity of this enzyme to effectively induce the death of bystander cells. we have shown that fusion of tk to an 11-amino acid peptide from the basic domain of the human immunodeficiency virus type 1 tat protein (tat11) imparts cell membrane-translocating ability to the enzyme and significantly increases its cytotoxic activity. here we report on the efficacy of this s ... | 2005 | 16390270 |
| to replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control. | to ensure that their mrnas are translated and that the viral proteins necessary for assembling the next generation of infectious progeny are produced, viruses must effectively seize control of the translational machinery within their host cells. in many cases, the ability to productively engage host translational components can determine if a given cell type can support viral replication, illustrating the critical importance of this task in the viral life cycle. failure to interface properly wit ... | 2005 | 16299530 |
| a deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. | the largest tegument protein of herpes simplex virus 1 (hsv-1), ul36, contains a novel deubiquitinating activity embedded in it. all members of the herpesviridae contain a homologue of hsv-1 ul36, the n-terminal segments of which show perfect conservation of those residues implicated in catalysis. for murine cytomegalovirus and epstein-barr virus, chosen as representatives of the beta- and gammaherpesvirus subfamilies, respectively, we here show that the homologous modules indeed display deubiqu ... | 2005 | 16306630 |
| evaluation of antiviral activity of compounds isolated from ranunculus sieboldii and ranunculus sceleratus. | nineteen compounds isolated from ranunculus sieboldii and ranunculus sceleratus were tested for inhibitory effects on hepatitis b virus (hbv) and herpes simplex virus type-1 (hsv-1). the results showed that apigenin 4'- o- alpha-rhamnopyranoside, apigenin 7- o- beta-glucopyranosyl-4'- o- alpha-rhamnopyranoside, tricin 7- o- beta-glucopyranoside, tricin, and isoscopoletin possessed inhibitory activity against hbv replication. protocatechuyl aldehyde exhibited an inhibiting activity on hsv-1 repli ... | 2005 | 16395649 |
| sexually transmitted infections, blood-borne viruses and risk behaviour in an australian senior high school population--the shlirp study. | to determine the feasibility and acceptability of screening for sexually transmitted infections and blood-borne viruses and to study the profile of sexual activity and other risk behaviours in a senior high school population. | 2005 | 16402670 |
| famciclovir for the treatment of recurrent genital and labial herpes lesions. | famciclovir (famvir, novartis) is an effective treatment for herpes zoster and herpes simplex. two separate studies recently examined the effectiveness of single high doses of famciclovir for treating recurrent genital herpes and labial herpes (cold sores). in the randomized, placebo-controlled studies, patients initiated treatment at the first onset of symptoms. for the treatment of genital herpes, a 1,000 mg b.i.d. dose of famciclovir had significant advantages over the placebo, reducing the t ... | 2005 | 16408140 |
| comparative study of macrophage response in mice after dna immunization and infection with herpes simplex virus type 1. | functional activity of macrophages and intensity of t cell immune response in mice were studied after intravaginal and intraperitoneal infection with herpes simplex virus type 1 and dna vaccination in combination with adjuvant treatment (recombinant granulocyte-macrophage colony-stimulating factor and glucosaminylmuramyl dipeptide). dna vaccination induced a virus-specific t cell immune response with no macrophagic inflammatory reaction. infection with herpes simplex virus type 1 was accompanied ... | 2005 | 16848234 |
| herpes simplex virus type 1 in peptic ulcer disease: an inverse association with helicobacter pylori. | to assess the frequency of herpes simplex virus type i in upper gastrointestinal tract ulcers and normal mucosa with the modern and better assays and also with a larger number of well characterized patients and controls and its relationship to helicobacter pylori(h pylori). | 2005 | 16425358 |